|
Category: flavor and fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | white to off-white powder (est) |
| Heavey Metals: | <10.00 ppm |
| Food Chemicals Codex Listed: | Yes |
| Melting Point: | 76.00 to 78.00 °C. @ 760.00 mm Hg
|
| Boiling Point: | 285.00 to 294.00 °C. @ 760.00 mm Hg
|
| Vapor Pressure: | 0.000880 mmHg @ 25.00 °C. (est) |
| Flash Point: | 293.00 °F. TCC ( 145.00 °C. )
|
| logP (o/w): | 1.580 |
| Shelf Life: | 24.00 month(s) or longer if stored properly. |
| Storage: | store in cool, dry place in tightly sealed containers, protected from heat and light. |
| Soluble in: |
| | chloroform | | | ethyl alcohol, 1gm. in 3cc of 95% alcohol at 32°F | | | ethyl alcohol, 2 vol. 95% alcohol | | | ethyl alcohol, 4.81 g. in 100ml. 80% propylene glycol/ 20% water by volume at 77 | | | fixed oils | | | glycerin | | | propylene glycol | | | water, 2867 mg/L @ 25 °C (est) | | | water, 2820 mg/L @ 25 °C (exp) |
| Insoluble in: |
| | paraffin oil |
| Stability: |
| | cream | | | hair spray | | | lipstick | | | lotion | | | powder | | | store in cool place in sealed containers |
Organoleptic Properties:
| Odor Type: | vanilla |
| Odor Strength: | medium , recommend smelling in a 10.00 % solution or less |
Odor Description: at 10.00 % in dipropylene glycol. | sweet creamy vanilla caramel |
| Substantivity: | 400 Hour(s) |
| | |
Cosmetic Information:
Safety Information:
| Most important hazard(s): | | Xn - Harmful. |
| |
R 22 - Harmful if swallowed. R 36/37/38 - Irritating to eyes, respiratory system, and skin. S 02 - Keep out of the reach of children. S 24/25 - Avoid contact with skin and eyes. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 36 - Wear suitable protective clothing.
|
| Oral/Parenteral Toxicity: | | |
gavage-rat LD50 [sex: M,F] > 2000 mg/kg (Jenner et al., 1964)
gavage-rat LD50 [sex: M] 4470 mg/kg (Rhône-Poulenc, Inc., 1992b)
oral-rat LD50 [sex: M,F] 3500 mg/kg Administered as a 10% solution in corn oil. (Monsanto Co., 1991a)
oral-rat LD50 [sex: M,F] 3500 mg/kg Administered as a 20% solution-suspension in corn oil. (Monsanto Co., 1991b)
gavage-rabbit LD50 2000 mg/kg (Deichmann & Kitzmiller, 1940)
intravenous-dog LDLo 760 mg/kg Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. Vol. 238, Pg. 2576, 1954.
intraperitoneal-guinea pig LD50 1140 mg/kg Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. Vol. 238, Pg. 2576, 1954.
intraperitoneal-mouse LD50 750 mg/kg Clinical Toxicology. Vol. 10, Pg. 61, 1977.
oral-rabbit LDLo 3000 mg/kg Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 29, Pg. 425, 1940.
oral-rat LD50 1590 mg/kg FAO Nutrition Meetings Report Series. Vol. 44A, Pg. 39, 1967.
|
| Dermal Toxicity: | | |
skin-rabbit LD50 > 7940 mg/kg National Technical Information Service. Vol. OTS0534355
subcutaneous-rat LDLo 1800 mg/kg Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 29, Pg. 425, 1940.
|
| Inhalation Toxicity: | | |
Not determined
|
Safety in Use Information:
| Category: | flavor and fragrance agents |
| Recommendation for ethyl vanillin usage levels up to: | | | 8.0000 % in the fragrance concentrate.
|
| |
| Maximised Survey-derived Daily Intakes (MSDI-EU): | 5400.00 (μg/capita/day) |
| Maximised Survey-derived Daily Intakes (MSDI-USA): | 43000.00 (μg/capita/day) |
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). |
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library |
| publication number: 3 |
| Click here to view publication 3 |
| | average usual ppm | average maximum ppm |
| baked goods: | - | 63.00000 |
| beverages(nonalcoholic): | - | 20.00000 |
| beverages(alcoholic): | - | 100.00000 |
| breakfast cereal: | - | - |
| cheese: | - | - |
| chewing gum: | - | 110.00000 |
| condiments / relishes: | - | - |
| confectionery froastings: | 140.00000 | 200.00000 |
| egg products: | - | - |
| fats / oils: | - | - |
| fish products: | - | - |
| frozen dairy: | - | 47.00000 |
| fruit ices: | - | 47.00000 |
| gelatins / puddings: | - | 74.00000 |
| granulated sugar: | - | - |
| gravies: | - | - |
| hard candy: | - | 65.00000 |
| imitation dairy: | - | - |
| instant coffee / tea: | - | - |
| jams / jellies: | - | - |
| meat products: | - | - |
| milk products: | - | - |
| nut products: | - | - |
| other grains: | - | - |
| poultry: | - | - |
| processed fruits: | - | - |
| processed vegetables: | - | - |
| reconstituted vegetables: | - | - |
| seasonings / flavors: | - | - |
| snack foods: | - | - |
| soft candy: | - | - |
| soups: | - | - |
| sugar substitutes: | - | - |
| sweet sauces: | - | - |
Safety References:
| Flavor & Extract Manufacturers Association (FEMA) reference(s): |
| The FEMA GRAS assessment of hydroxyl- and alkoxy-substituted benzyl derivatives used as flavor ingredients.View pdf |
| European Food Safety Athority(efsa): | Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies... |
| European Food Safety Authority (EFSA) reference(s): |
Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the Commission related to Flavouring Group Evaluation 20 (FGE.20): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical group 23 View page or View pdf |
Flavouring Group Evaluation 52 (FGE.52): Consideration of hydroxy- and alkoxy-substituted benzyl derivatives evaluated by JECFA (57th meeting) structurally related to benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters evaluated by EFSA in FGE.20 (2005) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) View page or View pdf |
Flavouring Group Evaluation 54 (FGE.54)[1] - Consideration of benzyl derivatives evaluated by JECFA (57th meeting) structurally related to benzyl alcohols, benzaldehydes, a related acetal, benzoic acids and related esters evaluated by EFSA in FGE.20 (2005) - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food View page or View pdf |
Flavouring Group Evaluation 20, Revision 1 (FGE.20Rev1): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids and related esters from chemical group 23 View page or View pdf |
Flavouring Group Evaluation 54, Revision 1 (FGE.54Rev1): Consideration of benzyl derivatives evaluated by JECFA (57th meeting) structurally related to benzyl alcohols, benzaldehydes, a related acetal, benzoic acids and related esters evaluated by EFSA in FGE.20Rev1 (2009) View page or View pdf |
Scientific Opinion on Flavouring Group Evaluation 20, Revision 2 (FGE.20Rev2): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical groups 23 and 30 View page or View pdf |
Scientific Opinion on Flavouring Group Evaluation 20, Revision 3(FGE.20Rev3): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical groups 23 and 30 View page or View pdf |
| EPI System: | View |
| NLM Hazardous Substances Data Bank: | Search |
| Chemical Carcinogenesis Research Information System: | Search |
| Cancer Citations: | Search |
| Env. Mutagen Info. Center: | Search |
| EPA Substance Registry Services (TSCA): | 121-32-4 |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 8467 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 1 |
| | 3-ethoxy-4-hydroxybenzaldehyde |
| Chemidplus: | 0000121324 |
| EPA/NOAA CAMEO: | hazardous materials |
| RTECS: | CU6125000 for cas# 121-32-4 |
References:
Other Information:
Potential Blenders and core components note
| |
| For Odor |
| No odor group found for these |
|
| | bird of paradise fragrance | FR |
| acidic |
| | cyclohexyl acetic acid | FL/FR |
| aldehydic |
| | acetyl nonyryl | FL/FR |
| amber |
| | cistus ladaniferus resinoid | FL/FR |
| animal |
| | animal carbolactone | FR |
| | costus valerolactone | FR |
| anise |
| | anise seed oil colombia | FL/FR |
| anisic |
| para- | acetanisole | FL/FR |
| ortho- | anisaldehyde | FL/FR |
| para- | anisaldehyde | FL/FR |
| | dihydroanethol | FL/FR |
| | methyl para-anisate | FL/FR |
| balsamic |
| 2- | acetyl furan | FL/FR |
| | benzoin | FL/FR |
| sumatra | benzoin absolute | FL/FR |
| siam | benzoin absolute | FL/FR |
| | benzoin absolute replacer | FL/FR |
| sumatra | benzoin gum | FL/FR |
| siam | benzoin resin | FL/FR |
| sumatra | benzoin resin | FL/FR |
| | benzoin resin replacer | FR |
| sumatra | benzoin resinoid | FL/FR |
| siam | benzoin resinoid | FL/FR |
| 1- | benzoyl acetone | FL/FR |
| | benzyl cinnamate | FL/FR |
| iso | butyl cinnamate | FL/FR |
| | cinnamyl alcohol | FL/FR |
| | ethyl cinnamate | FL/FR |
| | fir balsam absolute | FR |
| | guaiacyl phenyl acetate | FL/FR |
| | methyl cinnamate | FL/FR |
| | peru balsam absolute | FL/FR |
| | peru balsam oil | FL/FR |
| | peru balsam resinoid | FL/FR |
| 3- | phenyl propyl alcohol | FL/FR |
| berry |
| | raspberry ketone | FL/FR |
| | raspberry ketone acetate | FL/FR |
| | raspberry ketone methyl ether | FL/FR |
| bready |
| | coffee furanone | FL/FR |
| buttery |
| | acetoin | FL/FR |
| | acetyl butyryl | FL/FR |
| | acetyl isobutyryl | FL/FR |
| | acetyl propionyl | FL/FR |
| | butyl butyryl lactate | FL/FR |
| 3,4- | hexane dione | FL/FR |
| 2-oxo | butyric acid | FL/FR |
| | caramel furanone solution | FL/FR |
| | caramel pentadione | FL/FR |
| | coffee dione | FL/FR |
| | cyclotene | FL/FR |
| | cyclotene hydrate | FL/FR |
| alpha,alpha- | dimethyl anisyl acetone | FL/FR |
| | ethyl 2-hydroxy-2-methyl butyrate | FL/FR |
| | ethyl cyclopentenolone | FL/FR |
| | ethyl furaneol | FL/FR |
| | ethyl maltol | FL/FR |
| 5- | ethyl-2,3,4,5-tetramethyl-2-cyclohexen-1-one | FL/FR |
| | fenugreek absolute | FL/FR |
| | geranyl crotonate | FR |
| | immortelle absolute | FL/FR |
| | levulinic acid | FL/FR |
| | maltol | FL/FR |
| | maltyl propionate | FL/FR |
| | maple furanone | FL/FR |
| | menthone lactone | FL/FR |
| | mesitene lactone | FR |
| 5- | methyl furfural | FL/FR |
| | rosefuran | FL/FR |
| | shoyu furanone | FL/FR |
| | strawberry furanone | FL/FR |
| | strawberry furanone acetate | FL/FR |
| | strawberry furanone solution | FL/FR |
| | toffee furanone | FL/FR |
| cheesy |
| | butyric acid | FL/FR |
| chemical |
| | styralyl alcohol | FL/FR |
| chocolate |
| iso | amyl phenyl acetate | FL/FR |
| | chocolate specialty | FR |
| | vanillyl ethyl ether | FL/FR |
| citrus |
| blood | orange oil italy | FL/FR |
| sweet | orange peel oil c.p. brazil | FL/FR |
| coconut |
| alpha- | angelica lactone | FL/FR |
| | coconut decanone methyl | FR |
| delta- | decalactone | FL/FR |
| delta-2- | dodecenolactone | FL/FR |
| gamma- | heptalactone | FL/FR |
| delta- | nonalactone | FL/FR |
| gamma- | nonalactone (aldehyde C-18 (so-called)) | FL/FR |
| gamma- | octalactone | FL/FR |
| delta- | undecalactone | FL/FR |
| coumarinic |
| | coumane | FL/FR |
| | tonka bean resinoid | FR |
| creamy |
| | butyl lactate | FL/FR |
| gamma- | butyrolactone | FL/FR |
| | creamy lactone | FL/FR |
| | cyclotene propionate | FL/FR |
| | geranyl ethyl acetal | FR |
| 3- | heptyl dihydro-5-methyl-2(3H)-furanone | FL/FR |
| para- | vanillic acid | FL/FR |
| para- | vanillyl alcohol | FL/FR |
| | veratraldehyde | FL/FR |
| earthy |
| 1- | nonen-3-ol | FL/FR |
| ethereal |
| | ethyl 4-pentenoate | FL/FR |
| | ethyl pyruvate | FL/FR |
| iso | valeraldehyde propylene glycol acetal | FL/FR |
| fatty |
| (Z)- | dairy lactone | FL/FR |
| | ethyl undecylenate | FL/FR |
| 4- | methyl octanoic acid | FL/FR |
| fermented |
| | butyl laevo-lactate | FL/FR |
| | ethyl (E)-2-crotonate | FL/FR |
| floral |
| | acetophenone | FL/FR |
| | coffee flower absolute | FR |
| para- | cresyl laurate | FL/FR |
| | cyclohexyl ethyl alcohol | FL/FR |
| alpha- | damascone | FL/FR |
| | dihydrojasmone | FL/FR |
| | dimethyl benzyl carbinyl butyrate | FL/FR |
| | ethyl phenyl acetate | FL/FR |
| | floral pyranol | FR |
| | heliotropin | FL/FR |
| | heliotropyl acetate | FL/FR |
| | heliotropyl acetone | FL/FR |
| | heliotropyl diethyl acetal | FR |
| | hyacinth ether | FR |
| para- | methyl acetophenone | FL/FR |
| | methyl dihydrojasmonate | FL/FR |
| beta- | naphthyl methyl ketone | FL/FR |
| | nerolidol | FL/FR |
| | peony alcohol | FR |
| | phenethyl acetate | FL/FR |
| | phenethyl alcohol | FL/FR |
| | phenethyl isobutyrate | FL/FR |
| | phenethyl phenyl acetate | FL/FR |
| | rose butanoate | FL/FR |
| | violet methyl carbonate | FR |
| fruity |
| | acetoin acetate | FL/FR |
| para- | anisyl propionate | FL/FR |
| | artemisia pallens herb oil | FL/FR |
| beta- | damascone | FL/FR |
| gamma- | decalactone | FL/FR |
| | ethyl methyl-para-tolyl glycidate | FL/FR |
| (E)- | ethyl tiglate | FL/FR |
| | farnesyl acetone | FL/FR |
| | guaiacyl propionate | FL/FR |
| | methyl (Z)-5-octenoate | FL/FR |
| | octyl butyrate | FL/FR |
| | tetrahydrofurfuryl acetate | FL/FR |
| | tolualdehydes (mixed o,m,p) | FL/FR |
| gamma- | undecalactone (aldehyde C-14 (so-called)) | FL/FR |
| | vanilla carboxylate | FL/FR |
| green |
| iso | amyl 3-(2-furan) propionate | FL/FR |
| iso | butyl benzyl carbinol | FL/FR |
| (Z)-4- | hepten-1-ol | FL/FR |
| (Z)-4- | heptenal | FL/FR |
| (Z)-4- | heptenal diethyl acetal | FL/FR |
| (Z)-3- | hexen-1-yl propionate | FL/FR |
| | hexyl 2-methyl butyrate | FL/FR |
| | violet leaf absolute | FL/FR |
| hay |
| | beeswax absolute | FL/FR |
| | hay absolute | FR |
| herbal |
| | butyl levulinate | FL/FR |
| honey |
| | methyl phenyl acetate | FL/FR |
| | phenyl acetic acid | FL/FR |
| licorice |
| (E)- | anethol | FL/FR |
| melon |
| (Z)-6- | nonenal | FL/FR |
| | watermelon ketone | FR |
| milky |
| laevo- | glutamine | CS |
| minty |
| laevo- | carvone | FL/FR |
| | menthoxypropane diol | FL/FR |
| | vanillin menthoxypropane diol acetal | FL/FR |
| mossy |
| | veramoss (IFF) | FR |
| mushroom |
| 3- | octen-2-ol | FL/FR |
| musk |
| | ethylene brassylate | FL/FR |
| omega- | pentadecalactone | FL/FR |
| musty |
| 3- | acetyl-2,5-dimethyl furan | FL/FR |
| naphthyl |
| 2,4- | dimethyl benzaldehyde | FL/FR |
| para- | methyl anisole | FL/FR |
| beta- | naphthyl ethyl ether | FL/FR |
| nutty |
| 2- | acetyl-3,5(or 6)-dimethyl pyrazine | FL/FR |
| 2,3- | dimethyl pyrazine | FL/FR |
| | nutty cyclohexenone | FL/FR |
| | resorcinol | FR |
| 2,3,5,6- | tetramethyl pyrazine | FL/FR |
| phenolic |
| | ethyl vanillate | FL/FR |
| ortho- | guaiacol | FL/FR |
| 4- | methyl-2,6-dimethoxyphenol | FL/FR |
| popcorn |
| 2- | acetyl pyrazine | FL/FR |
| powdery |
| para- | anisyl acetate | FL/FR |
| para- | anisyl alcohol | FL/FR |
| 2,6- | dimethoxyphenol | FL/FR |
| alpha- | ethoxy-ortho-cresol | FL/FR |
| spicy |
| | allspice oil | FL/FR |
| para- | anisyl formate | FL/FR |
| | benzyl isoeugenol | FL/FR |
| | cassia bark oil china | FL/FR |
| | clove bud oil | FL/FR |
| | dianthus ethone | FR |
| 4- | ethyl guaiacol | FL/FR |
| iso | eugenyl acetate | FL/FR |
| 3-(2- | furyl) acrolein | FL/FR |
| (E)-para- | methoxycinnamaldehyde | FL/FR |
| para- | methoxycinnamaldehyde | FL/FR |
| alpha- | methyl cinnamaldehyde | FL/FR |
| 4- | methyl guaiacol | FL/FR |
| | methyl isoeugenol | FL/FR |
| cis- | oak lactone | |
| | spicy acetoacetate | FL/FR |
| | zingerone | FL/FR |
| sweet |
| | tonka bean absolute replacer | FR |
| | vanilla bean absolute (vanilla spp.) | FL/FR |
| | vanilla oleoresin bali | FL/FR |
| | vanilla oleoresin bourbon | FL/FR |
| | vanilla resinoid | FL/FR |
| | vanilla tahitensis fruit absolute | FR |
| | vanilla tahitensis fruit absolute CO2 extract | FL/FR |
| | vanilla tahitensis fruit extract | FL/FR |
| | vanilla tahitensis fruit oil CO2 extract | FR |
| tonka |
| 6- | amyl-alpha-pyrone | FL/FR |
| | coumarin | FR |
| gamma- | hexalactone | FL/FR |
| | mint lactone | FL/FR |
| | octahydrocoumarin | FL/FR |
| | tonka bean absolute | FR |
| tropical |
| | curcuma amada roxb. rhizome oil CO2 extract | FL/FR |
| vanilla |
| | acetovanillone | FL/FR |
| | crème brulee fragrance | FR |
| ortho- | dimethyl hydroquinone | FL/FR |
| | ethyl vanillin acetate | FR |
| | ethyl vanillin diethyl acetal | FR |
| | ethyl vanillin hexylene glycol acetal | FR |
| | ethyl vanillin isobutyrate | FL/FR |
| | ethyl vanillin propylene glycol acetal | FL/FR |
| | heliotropyl alcohol | FL/FR |
| | methyl vanillate | FL/FR |
| | propenyl guaethol | FL/FR |
| iso | propyl vanillin | |
| | vanilla | FR |
| | vanilla aromatica fruit extract | FL/FR |
| | vanilla bean absolute (vanilla planifolia) | FL/FR |
| | vanilla bean absolute CO2 extract (vanilla planifolia) | FL/FR |
| | vanilla bean fragrance | FR |
| | vanilla bean oil (vanilla planifolia) | FR |
| | vanilla bean oil (vanilla tahitensis) | FL/FR |
| | vanilla bean oil CO2 extract | FL/FR |
| | vanilla bean tincture | FR |
| | vanilla cresol | FR |
| | vanilla extract | FL/FR |
| country | vanilla fragrance | FR |
| | vanilla fragrance | FR |
| french | vanilla fragrance | FR |
| | vanilla planifolia fruit extract | FL/FR |
| | vanilla planifolia fruit infusion | FR |
| | vanilla planifolia fruit water | FL/FR |
| | vanilla specialty | FR |
| | vanillin | FL/FR |
| | vanillin 2,3-butylene glycol acetal | FL/FR |
| | vanillin hexylene glycol acetal | FR |
| | vanillin propylene glycol acetal | FL/FR |
| | vanillyl acetate | FL/FR |
| | vanillyl butyl ether | FL/FR |
| | vanillyl isobutyrate | FL/FR |
| | vanillylidene acetone | FL/FR |
| vegetable |
| | methional | FL/FR |
| | tetrahydrofurfuryl alcohol | FL/FR |
| waxy |
| | allyl nonanoate | FL/FR |
| | ethyl palmitate | FL/FR |
| | methyl laurate | FL/FR |
| 2- | nonanol | FL/FR |
| | octyl isobutyrate | FL/FR |
| delta- | tetradecalactone | FL/FR |
| | undecanoic acid | FL/FR |
| woody |
| | guaiacwood extract acetate | FR |
| | guaiacwood oil | FL/FR |
| | guaiacyl acetate | FL/FR |
| | gurjun balsam oil | FR |
| 4- | hydroxybenzaldehyde | FL/FR |
| | patchouli ethanone | FR |
| | patchouli oil | FL/FR |
| | sandal pentanol | FR |
| | santall | FR |
| | tobacarol (IFF) | FR |
| | vetiver oil haiti | FL/FR |
| |
| For Flavor |
| |
| No flavor group found for these |
| 2- | acetyl-3,4,5,6-tetrahydropyridine | FL |
| | allyl 2-furoate | FL |
| | allyl methyl trisulfide | FL |
| para- | anisyl propionate | FL/FR |
| | benzoin | FL/FR |
| 1- | benzoyl acetone | FL/FR |
| | benzyl disulfide | FL |
| | cistus ladaniferus resinoid | FL/FR |
| | coumane | FL/FR |
| | cyclotene propionate | FL/FR |
| 6- | decenoic acid | FL |
| 2,5- | diethyl tetrahydrofuran | FL |
| alpha,alpha- | dimethyl anisyl acetone | FL/FR |
| ortho- | dimethyl hydroquinone | FL/FR |
| delta-2- | dodecenolactone | FL/FR |
| alpha- | ethoxy-ortho-cresol | FL/FR |
| | ethyl 2-hydroxy-2-methyl butyrate | FL/FR |
| | ethyl 4-pentenoate | FL/FR |
| 5- | ethyl-2,3,4,5-tetramethyl-2-cyclohexen-1-one | FL/FR |
| | farnesyl acetone | FL/FR |
| | furfuryl acetone | FL |
| 3-(2- | furyl) acrolein | FL/FR |
| | glucoethyl vanillin | FL |
| | glucovanillin | FL |
| | guaiacyl propionate | FL/FR |
| | heliotropyl alcohol | FL/FR |
| | menthone lactone | FL/FR |
| | menthoxypropane diol | FL/FR |
| (E)-para- | methoxycinnamaldehyde | FL/FR |
| 4- | methoxysalicylaldehyde | FL |
| | methyl para-anisate | FL/FR |
| | methyl vanillate | FL/FR |
| cis- | oak lactone | |
| iso | propyl vanillin | |
| | rosefuran | FL/FR |
| | vanilla tahitensis fruit absolute CO2 extract | FL/FR |
| | vanillin menthoxypropane diol acetal | FL/FR |
| | vanillyl butyl ether | FL/FR |
| | vanilmandelic acid | FL |
|
| iso | amyl 3-(2-furan) propionate | FL/FR |
| beta- | damascone | FL/FR |
| acidic |
| | levulinic acid | FL/FR |
| aldehydic |
| | acetyl nonyryl | FL/FR |
| amber |
| iso | butyl benzyl carbinol | FL/FR |
| anise |
| (E)- | anethol | FL/FR |
| | anise seed oil colombia | FL/FR |
| anisic |
| para- | acetanisole | FL/FR |
| ortho- | anisaldehyde | FL/FR |
| balsamic |
| | benzoin absolute replacer | FL/FR |
| sumatra | benzoin gum | FL/FR |
| siam | benzoin resin | FL/FR |
| sumatra | benzoin resin | FL/FR |
| siam | benzoin resinoid | FL/FR |
| sumatra | benzoin resinoid | FL/FR |
| iso | butyl cinnamate | FL/FR |
| | ethyl cinnamate | FL/FR |
| | peru balsam | FL |
| | peru balsam absolute | FL/FR |
| | peru balsam oil | FL/FR |
| | peru balsam resinoid | FL/FR |
| | vanillylidene acetone | FL/FR |
| berry |
| | heliotropyl acetone | FL/FR |
| | raspberry ketone | FL/FR |
| | raspberry ketone acetate | FL/FR |
| | raspberry ketone methyl ether | FL/FR |
| bready |
| | mango furanone | FL |
| 2- | propionyl thiazole | FL |
| brown |
| | beeswax absolute | FL/FR |
| 2-oxo | butyric acid | FL/FR |
| 5- | methyl furfural | FL/FR |
| | tetrahydrofurfuryl acetate | FL/FR |
| burnt |
| | furfuryl alcohol | FL |
| buttery |
| | butter cream frosting flavor | FL |
| | butter nut vanilla flavor | FL |
| | butter vanilla nut flavor | FL |
| | butyl laevo-lactate | FL/FR |
| | diacetyl | FL |
| 3,4- | hexane dione | FL/FR |
| cabbage |
| | methyl 2-thiofuroate | FL |
| caramellic |
| | caramel furanone | FL |
| | caramel furanone solution | FL/FR |
| | caramel malted mambo flavor | FL |
| | caramel pentadione | FL/FR |
| | creme brulee flavor | FL |
| | cyclotene | FL/FR |
| | cyclotene hydrate | FL/FR |
| | ethyl furaneol | FL/FR |
| | ethyl maltol | FL/FR |
| 5- | ethyl-3,4,5,6-tetramethyl cyclohexen-2-one | FL |
| | fenugreek absolute | FL/FR |
| | lucuma flavor | FL |
| | maltol | FL/FR |
| | maltyl propionate | FL/FR |
| | maple cream flavor | FL |
| | maple furanone | FL/FR |
| 3- | methyl butyl 2-furyl butyrate | FL |
| | pyruvaldehyde | FL |
| | shoyu furanone | FL/FR |
| | strawberry furanone | FL/FR |
| | strawberry furanone acetate | FL/FR |
| | strawberry furanone solution | FL/FR |
| | toffee furanone | FL/FR |
| chemical |
| | styralyl alcohol | FL/FR |
| cherry |
| | heliotropin | FL/FR |
| para- | methoxycinnamaldehyde | FL/FR |
| citrus |
| blood | orange oil italy | FL/FR |
| sweet | orange peel oil c.p. brazil | FL/FR |
| coconut |
| delta- | decalactone | FL/FR |
| (R)- | massoia lactone | FL |
| 6- | methyl coumarin | FL |
| gamma- | nonalactone (aldehyde C-18 (so-called)) | FL/FR |
| | octahydrocoumarin | FL/FR |
| coffee |
| | coffee creme brulee flavor | FL |
| | coffee dione | FL/FR |
| 2- | thiophene thiol | FL |
| corn chip |
| 2- | acetyl-2-thiazoline | FL |
| creamy |
| | acetoin | FL/FR |
| | acetyl butyryl | FL/FR |
| | acetyl isobutyryl | FL/FR |
| 6- | amyl-alpha-pyrone | FL/FR |
| alpha- | angelica lactone | FL/FR |
| para- | anisaldehyde | FL/FR |
| | butyl butyryl lactate | FL/FR |
| | creamy lactone | FL/FR |
| | dihydrocoumarin | FL |
| | divanillin | FL |
| | ethyl vanillate | FL/FR |
| gamma- | hexalactone | FL/FR |
| 4- | hydroxybenzaldehyde | FL/FR |
| para- | methyl acetophenone | FL/FR |
| | mint lactone | FL/FR |
| delta- | nonalactone | FL/FR |
| | octyl isobutyrate | FL/FR |
| delta- | undecalactone | FL/FR |
| gamma- | undecalactone (aldehyde C-14 (so-called)) | FL/FR |
| para- | vanillic acid | FL/FR |
| para- | vanillyl alcohol | FL/FR |
| | veratraldehyde | FL/FR |
| dairy |
| | butyl lactate | FL/FR |
| | creme brulle coffee flavor | FL |
| | methyl (Z)-5-octenoate | FL/FR |
| earthy |
| 1- | nonen-3-ol | FL/FR |
| eggy |
| | egg nog creme brulee flavor | FL |
| fatty |
| (Z)- | dairy lactone | FL/FR |
| | diacetyl trimer | FL |
| | ethyl undecylenate | FL/FR |
| 4- | methyl octanoic acid | FL/FR |
| 2,4- | octadien-1-ol | FL |
| (E,E)-2,4- | undecadienal | FL |
| 2,4- | undecadienal | FL |
| floral |
| iso | amyl phenyl acetate | FL/FR |
| | dihydrojasmone | FL/FR |
| | dimethyl benzyl carbinyl butyrate | FL/FR |
| | heliotropyl acetate | FL/FR |
| | methyl dihydrojasmonate | FL/FR |
| | methyl phenyl acetate | FL/FR |
| beta- | naphthyl methyl ketone | FL/FR |
| | phenethyl alcohol | FL/FR |
| | phenyl acetic acid | FL/FR |
| fruity |
| | acetoin acetate | FL/FR |
| | acetyl isovaleryl | FL |
| para- | anisyl acetate | FL/FR |
| para- | anisyl alcohol | FL/FR |
| | artemisia pallens herb oil | FL/FR |
| alpha- | damascone | FL/FR |
| gamma- | decalactone | FL/FR |
| | ethyl 3-oxohexanoate | FL |
| | ethyl methyl-para-tolyl glycidate | FL/FR |
| (E)- | ethyl tiglate | FL/FR |
| | furfuryl valerate | FL |
| 3- | heptyl dihydro-5-methyl-2(3H)-furanone | FL/FR |
| (E,E)- | methyl sorbate | FL |
| 2- | pentanoyl furan | FL |
| | rose butanoate | FL/FR |
| | tolualdehydes (mixed o,m,p) | FL/FR |
| iso | valeraldehyde propylene glycol acetal | FL/FR |
| | vanilla carboxylate | FL/FR |
| green |
| | cinnamyl alcohol | FL/FR |
| | cyclohexyl ethyl alcohol | FL/FR |
| | heptanal 2,3-butane diol acetal | FL |
| (Z)-4- | hepten-1-ol | FL/FR |
| (Z)-4- | heptenal | FL/FR |
| (Z)-4- | heptenal diethyl acetal | FL/FR |
| (Z)-3- | hexen-1-yl propionate | FL/FR |
| | hexyl 2-methyl butyrate | FL/FR |
| | immortelle absolute | FL/FR |
| | nerolidol | FL/FR |
| (Z)-6- | nonenal | FL/FR |
| | violet leaf absolute | FL/FR |
| herbal |
| | butyl levulinate | FL/FR |
| | dihydroanethol | FL/FR |
| 5- | hydroxymethyl furfural | FL |
| honey |
| | ethyl phenyl acetate | FL/FR |
| | phenethyl acetate | FL/FR |
| | phenethyl isobutyrate | FL/FR |
| | phenethyl phenyl acetate | FL/FR |
| jammy |
| | ethyl cyclopentenolone | FL/FR |
| lactonic |
| gamma- | heptalactone | FL/FR |
| gamma- | octalactone | FL/FR |
| meaty |
| 4- | allyl-2,6-dimethoxyphenol | FL |
| medicinal |
| 2,6- | dimethoxyphenol | FL/FR |
| milky |
| gamma- | butyrolactone | FL/FR |
| minty |
| laevo- | carvone | FL/FR |
| mushroom |
| 3- | octen-2-ol | FL/FR |
| musk |
| | ethylene brassylate | FL/FR |
| musty |
| | ethyl (E)-2-crotonate | FL/FR |
| naphthyl |
| 2,4- | dimethyl benzaldehyde | FL/FR |
| para- | methyl anisole | FL/FR |
| nutty |
| 2- | acetyl furan | FL/FR |
| 3- | acetyl-2,5-dimethyl furan | FL/FR |
| 2- | acetyl-3,5(or 6)-dimethyl pyrazine | FL/FR |
| | coffee furanone | FL/FR |
| 2,3- | dimethyl pyrazine | FL/FR |
| | furfural acetone | FL |
| | nutty cyclohexenone | FL/FR |
| | peanut oxazole | FL |
| | tetrahydrofurfuryl alcohol | FL/FR |
| 2,3,5,6- | tetramethyl pyrazine | FL/FR |
| phenolic |
| | guaiacyl phenyl acetate | FL/FR |
| 4- | methyl-2,6-dimethoxyphenol | FL/FR |
| powdery |
| | acetophenone | FL/FR |
| beta- | naphthyl ethyl ether | FL/FR |
| | powdery ketone | FL |
| roasted |
| 2- | acetyl pyrazine | FL/FR |
| rummy |
| | ethyl pyruvate | FL/FR |
| | vanillyl ethyl ether | FL/FR |
| sour |
| | butyric acid | FL/FR |
| spicy |
| | allspice oil | FL/FR |
| para- | anisyl formate | FL/FR |
| siam | benzoin absolute | FL/FR |
| sumatra | benzoin absolute | FL/FR |
| | benzyl cinnamate | FL/FR |
| | benzyl isoeugenol | FL/FR |
| | benzylidene acetone | FL |
| | cassia bark oil china | FL/FR |
| | clove bud oil | FL/FR |
| iso | eugenyl acetate | FL/FR |
| alpha- | methyl cinnamaldehyde | FL/FR |
| | methyl cinnamate | FL/FR |
| | methyl isoeugenol | FL/FR |
| 3- | phenyl propyl alcohol | FL/FR |
| | root beer float flavor | FL |
| | spicy acetoacetate | FL/FR |
| chai | vanilla flavor | FL |
| | zingerone | FL/FR |
| sweet |
| | caramel dione | FL |
| | cyclohexyl acetic acid | FL/FR |
| | ethyl 3-(2-hydroxyphenyl) propionate | FL |
| | molasses flavor | FL |
| | orange vanilla cream flavor | FL |
| | vanilla bean absolute (vanilla spp.) | FL/FR |
| | vanilla bean aromatica | FL |
| | vanilla bean planifolia | FL |
| | vanilla butter nut flavor | FL |
| | vanilla concentrate | FL |
| | vanilla oleoresin bali | FL/FR |
| | vanilla oleoresin bourbon | FL/FR |
| | vanilla resinoid | FL/FR |
| | vanilla tahitensis fruit extract | FL/FR |
| toasted |
| | acetyl propionyl | FL/FR |
| tomato |
| | methional | FL/FR |
| tropical |
| | curcuma amada roxb. rhizome oil CO2 extract | FL/FR |
| vanilla |
| | acetovanillone | FL/FR |
| vanilla | chai flavor | FL |
| | ethyl vanillin isobutyrate | FL/FR |
| | ethyl vanillin propylene glycol acetal | FL/FR |
| vanilla | ice cream flavor | FL |
| 4- | methyl guaiacol | FL/FR |
| omega- | pentadecalactone | FL/FR |
| | propenyl guaethol | FL/FR |
| | vanilla aromatica fruit extract | FL/FR |
| | vanilla bean absolute (vanilla planifolia) | FL/FR |
| | vanilla bean absolute CO2 extract (vanilla planifolia) | FL/FR |
| | vanilla bean flavor key | FL |
| | vanilla bean oil (vanilla tahitensis) | FL/FR |
| | vanilla bean oil CO2 extract | FL/FR |
| | vanilla bean paste | FL |
| | vanilla bean powder | FL |
| | vanilla bean tahitensis | FL |
| | vanilla distillates | FL |
| | vanilla extract | FL/FR |
| bourbon | vanilla flavor | FL |
| bakers white | vanilla flavor | FL |
| french | vanilla flavor | FL |
| | vanilla flavor | FL |
| | vanilla flavor key | FL |
| | vanilla hazelnut flavor | FL |
| | vanilla macadamia nut flavor | FL |
| | vanilla nut creme flavor | FL |
| | vanilla pandan flavor | FL |
| | vanilla planifolia fruit extract | FL/FR |
| | vanilla planifolia fruit water | FL/FR |
| | vanilla powder flavor | FL |
| | vanilla swirl flavor | FL |
| | vanillin | FL/FR |
| | vanillin 2,3-butylene glycol acetal | FL/FR |
| | vanillin propylene glycol acetal | FL/FR |
| | vanillyl acetate | FL/FR |
| | vanillyl isobutyrate | FL/FR |
| waxy |
| | allyl nonanoate | FL/FR |
| para- | cresyl laurate | FL/FR |
| | ethyl palmitate | FL/FR |
| | furfuryl octanoate | FL |
| | methyl laurate | FL/FR |
| 2- | nonanol | FL/FR |
| | octyl 2-furoate | FL |
| | octyl butyrate | FL/FR |
| delta- | tetradecalactone | FL/FR |
| | undecanoic acid | FL/FR |
| woody |
| 4- | ethyl guaiacol | FL/FR |
| ortho- | guaiacol | FL/FR |
| | guaiacwood oil | FL/FR |
| | guaiacyl acetate | FL/FR |
| | patchouli oil | FL/FR |
| | vetiver oil haiti | FL/FR |
| |
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | bourbonal | | | ethavan | | | ethovan | | 3- | ethoxy protocatechualdehyde | | 2- | ethoxy-4-formyl phenol | | 3- | ethoxy-4-hydroxy-benzaldehyde | | 3- | ethoxy-4-hydroxybenzaldehyde | | 3- | ethoxy-4-oxidanyl-benzaldehyde | | 3- | ethoxyprotocatechualdehyde | | | ethyl protal | | | ethyl protocatechualdehyde-3-ethyl ether | | | ethyl protocatechuic aldehyde | | | ethyl vanillin 10% dpg | | | ethyl vanillin FCC | | | ethyl vanillin N.F. | | | ethyl vanillin NF | | | ethyl vanillin synthetic | | | ethylprotal | | | ethylprotocatechualdehyde-3-ethyl ether | | | ethylprotocatechuic aldehyde | | | ethylvanillin | | 4- | hydroxy-3-ethoxybenzaldehyde | | | protocatechuic aldehyde ethyl ether | | | quantrovanil | | | rhodiarome | | | rhodiascent | | | vanillin, ethyl- | | | vanirome |
Articles:
| PubMed: | Determination of flavor enhancers in milk powder by one-step sample preparation and two-dimensional liquid chromatography. |
| J-Stage: | Antioxidant Properties of Ethyl Vanillin in Vitro and in Vivo |
| PubMed: | Laccase catalyzed synthesis of iodinated phenolic compounds with antifungal activity. |
| PubMed: | A vanillin derivative causes mitochondrial dysfunction and triggers oxidative stress in Cryptococcus neoformans. |
| PubMed: | Determination of vanillin, ethyl vanillin, and coumarin in infant formula by liquid chromatography-quadrupole linear ion trap mass spectrometry. |
| PubMed: | The missense of smell: functional variability in the human odorant receptor repertoire. |
| PubMed: | Oxidative decarboxylation of mandelic acid derivative by recombinant Escherichia coli: a novel method of ethyl vanillin synthesis. |
| PubMed: | A systematic approach for optimizing the robustness of pulse sequence elements with respect to couplings, offsets, and B1-field inhomogeneities (COB). |
| PubMed: | Phenolic compounds in particles of mainstream waterpipe smoke. |
| PubMed: | Thermal tolerance and survival of Cronobacter sakazakii in powdered infant formula supplemented with vanillin, ethyl vanillin, and vanillic acid. |
| PubMed: | Effect of vanillin and ethyl vanillin on cytochrome P450 activity in vitro and in vivo. |
| PubMed: | Molecularly imprinted photonic hydrogels as colorimetric sensors for rapid and label-free detection of vanillin. |
| PubMed: | Effect of vanillin, ethyl vanillin, and vanillic acid on the growth and heat resistance of Cronobacter species. |
| PubMed: | Antioxidant properties of ethyl vanillin in vitro and in vivo. |
| PubMed: | Differential presence of anthropogenic compounds dissolved in the marine waters of Puget Sound, WA and Barkley Sound, BC. |
| PubMed: | Simultaneous spectrophotometric kinetic determination of four flavor enhancers in foods with the aid of chemometrics. |
| PubMed: | A comprehensive evaluation of the toxicology of cigarette ingredients: aromatic carbonyl compounds. |
| PubMed: | Synthesis and anticancer activity of some novel tetralin-6-yl-pyrazoline, 2-thioxopyrimidine, 2-oxopyridine, 2-thioxo-pyridine and 2-iminopyridine derivatives. |
| PubMed: | [Studies on the chemical constituents of marine sponge Iotrochota sp]. |
| PubMed: | Conformational equilibria in vanillin and ethylvanillin. |
| PubMed: | Assessment of the anti-angiogenic, anti-inflammatory and antinociceptive properties of ethyl vanillin. |
| PubMed: | Microencapsulation of flavors in carnauba wax. |
| PubMed: | Fast single run of vanilla fingerprint markers on microfluidic-electrochemistry chip for confirmation of common frauds. |
| PubMed: | Intragastric administration of TRPV1, TRPV3, TRPM8, and TRPA1 agonists modulates autonomic thermoregulation in different manners in mice. |
| PubMed: | Rapid method for the determination of coumarin, vanillin, and ethyl vanillin in vanilla extract by reversed-phase liquid chromatography with ultraviolet detection. |
| PubMed: | Dihydroagarofuranoid sesquiterpenes, a lignan derivative, a benzenoid, and antitubercular constituents from the stem of Microtropis japonica. |
| PubMed: | Competitive and noncompetitive odorant interactions in the early neural coding of odorant mixtures. |
| PubMed: | 3-Eth-oxy-4-hydroxy-benzaldehyde. |
| PubMed: | Synthesis and non-aqueous medium titrations of some new 4-benzylidenamino-4,5-dihydro-1H-1,2,4-triazol-5-one derivatives. |
| PubMed: | Rapid sample screening method for authenticity controlling vanilla flavors using a CE microchip approach with electrochemical detection. |
| PubMed: | Optical recording of the intrinsic signal from the human olfactory cleft. |
| PubMed: | Determination of coumarin, vanillin, and ethyl vanillin in vanilla extract products: liquid chromatography mass spectrometry method development and validation studies. |
| PubMed: | Electrophysiological and behavioral responses to chocolate volatiles in both sexes of the pyralid moths Ephestia cautella and Plodia interpunctella. |
| PubMed: | Qualitative determination of false-positive effects in the acetylcholinesterase assay using thin layer chromatography. |
| PubMed: | Optimum methamphetamine profiling with sample preparation by solid-phase microextraction. |
| PubMed: | Identification of impurities and statistical classification of methamphetamine tablets (Ya-Ba) seized in Thailand. |
| PubMed: | Human potency predictions for aldehydes using the local lymph node assay. |
| PubMed: | Liquid chromatographic determination of vanillin and related aromatic compounds. |
| PubMed: | Odor response properties of rat olfactory receptor neurons. |
| PubMed: | Identification of coumarin as the sensitizer in a patient sensitive to her own perfume but negative to the fragrance mix. |
| PubMed: | Odorants selectively activate distinct G protein subtypes in olfactory cilia. |
| PubMed: | Specificity of signal molecules in the activation of Agrobacterium virulence gene expression. |
| PubMed: | Determination of coumarin as an adulterant in vanilla flavoring products by high-performance liquid chromatography. |
| PubMed: | Identification of urinary 3-ethoxy-4-hydroxybenzoic and 3-ethoxy-4-hydroxymandelic acids after dietary intake of ethyl vanillin. |
| PubMed: | Immediate reactions to balsam of Peru, cassia oil and ethyl vanillin. |
| PubMed: | Determination of vanillin and ethyl vanillin in food products. |
| PubMed: | [On the polarographic and oscillopolarographic determination of the semicarbazones of vanillin and ethyl vanillin (IV)]. |
| PubMed: | Anti-tuberculosis agents derived from 3-ethoxy-4-hydroxybenzaldehyde. |
| PubMed: | [Differential subject for the correction of vanillin and ethyl vanillin]. |
|