EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

gamma-butyrolactone
4-hydroxybutyric acid lactone

Supplier Sponsors

Flavor Demo Formulas
Name:oxolan-2-one
CAS Number: 96-48-0Picture of molecule3D/inchi
Other:187997-16-6
ECHA EINECS - REACH Pre-Reg:202-509-5
FDA UNII:OL659KIY4X
Nikkaji Web:J3.971C
Beilstein Number:0105248
MDL:MFCD00005386
CoE Number:615
XlogP3:-0.60 (est)
Molecular Weight:86.09022000
Formula:C4 H6 O2
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:flavor and fragrance agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
JECFA Food Flavoring:219 4-hydroxybutyric acid lactone
FLAVIS Number:10.006 (Old)
DG SANTE Food Flavourings:10.006 butyro-1,4-lactone
FEMA Number:3291 4-hydroxybutyric acid lactone
FDA:No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF):96-48-0 ; 4-HYDROXYBUTANOIC ACID LACTONE
 
Physical Properties:
Appearance:colorless to pale yellow clear liquid (est)
Assay: 98.00 to 100.00
Food Chemicals Codex Listed: Yes
Specific Gravity:1.12000 to 1.13000 @ 25.00 °C.
Pounds per Gallon - (est).: 9.320 to 9.403
Refractive Index:1.43000 to 1.44000 @ 20.00 °C.
Melting Point: -43.30 °C. @ 760.00 mm Hg
Boiling Point: 204.00 to 205.00 °C. @ 760.00 mm Hg
Vapor Pressure:0.450000 mmHg @ 25.00 °C.
Vapor Density:3.00 ( Air = 1 )
Flash Point: 209.00 °F. TCC ( 98.33 °C. )
logP (o/w): -0.640
Soluble in:
 alcohol
 water, 1.00E+06 mg/L @ 25 °C (exp)
 
Organoleptic Properties:
Odor Type: creamy
Odor Strength:medium
creamy oily fatty caramellic
Odor Description:at 100.00 %. creamy oily fatty caramel
creamy oily fatty
Odor Description:Creamy, oily with fatty nuances
Mosciano, Gerard P&F 16, No. 2, 49, (1991)
Flavor Type: milky
milky creamy fruity peach
Taste Description: at 75.00 ppm. Milky, creamy with fruity peach-like afternotes
Mosciano, Gerard P&F 16, No. 2, 49, (1991)
Odor and/or flavor descriptions from others (if found).
Ernesto Ventós
BUTYROLACTONE GAMMA
Odor Description:SWEET, AROMATIC, CREAMY
Indukern F&F
GAMMA-BUTYROLACTONE
Odor Description:OILY, CREAMY, FATTY
Advanced Biotech
GAMMA-BUTYROLACTONE SYNTHETIC
Odor Description:Caramel, Fatty, Creamy
Prodasynth
GAMMA BUTYROLACTONE (> 98%)
Odor Description:SWEET, AROMATIC, CREAMY
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: masking agents
solvents
 
Suppliers:
Augustus Oils
Gamma Butyrolactone
Services
Beijing Lys Chemicals
gamma-Butyrolactone
Capot Chemical
gamma-Butyrolactone
Covalent Chemical
gamma-Butyrolactone
Diffusions Aromatiques
gamma-BUTYROLACTONE
Ernesto Ventós
BUTYROLACTONE GAMMA
Odor: SWEET, AROMATIC, CREAMY
Indukern F&F
GAMMA-BUTYROLACTONE
Odor: OILY, CREAMY, FATTY
Inoue Perfumery
gamma-BUTYROLACTONE
LyondellBasell Industries
gamma-Butyrolactone
M&U International
gamma-BUTYROLACTONE, Kosher
M&U International
NAT. gamma-BUTYROLACTONE
Penta International
GAMMA-BUTYROLACTONE FCC
Penta International
GAMMA-BUTYROLACTONE NATURAL
Penta International
GAMMA-BUTYROLACTONE SYNTHETIC 10% IN PROPYLENE GLYCOL
Penta International
gamma-BUTYROLACTONE
Prodasynth
GAMMA BUTYROLACTONE
(> 98%)
Odor: SWEET, AROMATIC, CREAMY
R C Treatt & Co Ltd
gamma-Butyrolactone
Shiva Chemicals and Pharmaceuticals
Gamma Butrolactone
Sigma-Aldrich
4-Hydroxybutanoic acid lactone, ≥98%, FCC, FG
Odor: caramel
Certified Food Grade Products
Synerzine
gamma-Butyrolactone
Tengzhou Xiang Yuan Aroma Chemicals
gamma-Butyrolactone
Vigon International
BUTYROLACTONE GAMMA
WEN International
Gamma-BUTYROLACTONE, natural
WholeChem
gamma-Butyrolactone
 
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
Xn - Harmful.
R 22 - Harmful if swallowed.
R 36 - Irritating to eyes.
R 41 - Risk of serious damage to eyes.
S 02 - Keep out of the reach of children.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36/39 - Wear suitable clothing and eye/face protection.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 1540 mg/kg
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 31(1), Pg. 49, 1987.

gavage-mouse LD50 1245 mg/kg
(Schafer & Bowles, 1985)

intraperitoneal-rat LD50 1000 mg/kg
BEHAVIORAL: GENERAL ANESTHETIC LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Archivum Immunologiae et Therapiae Experimentalis. Vol. 13, Pg. 70, 1965.

oral-mouse LD50 1460 mg/kg
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: GENERAL ANESTHETIC
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 64(2), Pg. 3, 1999.

intraperitoneal-mouse LD50 1100 mg/kg
BEHAVIORAL: GENERAL ANESTHETIC LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Archivum Immunologiae et Therapiae Experimentalis. Vol. 13, Pg. 70, 1965.

parenteral-mouse LDLo 1600 mg/kg
"Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. Vol. 7, Pg. 687, 1955.

intravenous-rabbit LDLo 500 mg/kg
Archivum Immunologiae et Therapiae Experimentalis. Vol. 13, Pg. 70, 1965.

Dermal Toxicity:
skin-guinea pig LD50 > 5000 mg/kg
GAF Material Safety Data Sheet.

Inhalation Toxicity:
inhalation-rat LC50 > 5100 mg/m3/4H
National Technical Information Service. Vol. OTS0534527

 
Safety in Use Information:
Category: flavor and fragrance agents
Recommendation for gamma-butyrolactone usage levels up to:
  0.5000 % in the fragrance concentrate.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 110.00 (μg/capita/day)
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 5
 average usual ppmaverage maximum ppm
baked goods: -20.00000
beverages(nonalcoholic): -10.00000
beverages(alcoholic): --
breakfast cereal: -20.00000
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: -10.00000
fruit ices: -10.00000
gelatins / puddings: --
granulated sugar: --
gravies: -10.00000
hard candy: -10.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: -10.00000
milk products: -10.00000
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: -10.00000
sugar substitutes: --
sweet sauces: --
 
Safety References:
European Food Safety Athority(efsa):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) on a request from the Commission related to - Flavouring Group Evaluation 10: Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30 - (Commission Regulation (EC) No 1565/2000 of 18 July 2000)
View page or View pdf

Flavouring Group Evaluation 10, Revision 1 (FGE10 Rev1)[1] - Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC)
View page or View pdf

Flavouring Group Evaluation 64 (FGE.64): Consideration of aliphatic acyclic diols, triols, and related substances evaluated by JECFA (57th meeting) structurally related to aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30 evaluated by EFSA in FGE.10Rev1 (EFSA, 2008ab)
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 92 (FGE.92): Consideration of aliphatic acyclic diols, triols, and related substances evaluated by JECFA (68th meeting) structurally related to aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones evaluated by EFSA in FGE.10Rev1 (2009)
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 10, Revision 2 (FGE.10Rev2): Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30
View page or View pdf

EPI System: View
NIOSH International Chemical Safety Cards:search
NLM Hazardous Substances Data Bank:Search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
Carcinogenic Potency Database:Search
EPA GENetic TOXicology:Search
Env. Mutagen Info. Center:Search
NLM Developmental and Reproductive Toxicity:Search
EPA Substance Registry Services (TSCA):96-48-0
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :7302
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
oxolan-2-one
Chemidplus:0000096480
EPA/NOAA CAMEO:hazardous materials
RTECS:96-48-0
 
References:
 oxolan-2-one
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:96-48-0
Pubchem (cid):7302
Pubchem (sid):134972536
Flavornet:96-48-0
Pherobase:View
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
CHEBI:View
CHEMBL:View
UM BBD:Search
KEGG (GenomeNet):C01770
HMDB (The Human Metabolome Database):HMDB00549
FooDB:FDB003392
Export Tariff Code:2932.29.6000
Haz-Map:View
Household Products:Search
MedlinePlusSupp:View
Typical G.C.
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
RSC Learn Chemistry:View
EFSA Update of results on the monitoring of furan levels in food:Read Report
EFSA Previous report: Results on the monitoring of furan levels in food:Read Report
EFSA Report of the CONTAM Panel on provisional findings on furan in food:Read Report
Formulations/Preparations:
•electronic-grade butyrolactone is about 99% pure . •grade: technical
 
Potential Blenders and core components note
For Odor
No odor group found for these
iso
valeraldehyde diethyl acetal
FL/FR
aldehydic
aldehydic
acetyl nonyryl
FL/FR
iso
valeraldehyde
FL/FR
balsamic
amyl cinnamate
FL/FR
buttery
acetoin
FL/FR
acetyl butyryl
FL/FR
acetyl isobutyryl
FL/FR
acetyl propionyl
FL/FR
butyl butyryl lactate
FL/FR
caramellic
2-oxo
butyric acid
FL/FR
strawberry furanone acetate
FL/FR
cheesy
butyric acid
FL/FR
2-
methyl hexanoic acid
FL/FR
coconut
coconut decanone methyl
FR
delta-
decalactone
FL/FR
delta-2-
dodecenolactone
FL/FR
delta-
nonalactone
FL/FR
gamma-
octalactone
FL/FR
delta-
undecalactone
FL/FR
coffee
furfuryl mercaptan
FL/FR
creamy
butyl lactate
FL/FR
creamy lactone
FL/FR
3-
heptyl dihydro-5-methyl-2(3H)-furanone
FL/FR
para-
vanillic acid
FL/FR
para-
vanillyl alcohol
FL/FR
earthy
1-
nonen-3-ol
FL/FR
ethereal
decyl propionate
FL/FR
fatty
allyl cyclohexyl hexanoate
FL/FR
allyl decanoate
FL/FR
butter esters
FL/FR
iso
butyl undecylenate
FL/FR
coconut absolute
FL/FR
(Z)-
dairy lactone
FL/FR
(R)-gamma-
decalactone
FL/FR
(S)-gamma-
decalactone
FL/FR
dodecyl butyrate
FL/FR
(Z)-
ethyl oleate
FL/FR
ethyl undecylenate
FL/FR
4-
methyl octanoic acid
FL/FR
(Z)-3-
octen-1-ol
FL/FR
perilla seed oil
FL/FR
sorbitan oleate
CS
(E,Z,Z)-2,4,7-
tridecatrienal
FL/FR
fermented
butyl laevo-lactate
FL/FR
floral
citronellyl formate
FL/FR
geraniol
FL/FR
jasmin pyranone
FL/FR
para-
methyl acetophenone
FL/FR
octanal / methyl anthranilate schiff's base
FR
2-
pentadecanone
FL/FR
fruity
acetoin acetate
FL/FR
allyl cyclohexyl butyrate
FL/FR
bitter
almond oil
FL/FR
iso
amyl 2-methyl butyrate
FL/FR
butyl 2-decenoate
FL/FR
cyclohexyl cinnamate
FL/FR
(S)-delta-
decalactone
FL/FR
gamma-
decalactone
FL/FR
epsilon-
dodecalactone
FL/FR
(S)-gamma-
dodecalactone
FL/FR
dodecyl isobutyrate
FL/FR
ethyl 5-hydroxyoctanoate
FL/FR
ethyl lactate
FL/FR
farnesyl acetone
FL/FR
(R)-(-)-2-
heptanol
FL/FR
(E)-2-
hepten-1-yl acetate
FL/FR
mango peach fragrance
FR
methyl (Z)-5-octenoate
FL/FR
methyl 3-nonenoate
FL/FR
octyl heptanoate
FL/FR
peach cyclopentanone
FR
peach pivalate
FR
3-
phenyl propyl hexanoate
FL/FR
plum crotonate
FR
gamma-
undecalactone (aldehyde C-14 (so-called))
FL/FR
2-
undecanone
FL/FR
vanilla carboxylate
FL/FR
green
iso
butyl benzyl carbinol
FL/FR
3-
heptanone
FL/FR
(Z)-4-
hepten-1-ol
FL/FR
(Z)-3-
hepten-1-ol
FL/FR
(Z)-4-
heptenal
FL/FR
(Z)-4-
heptenal diethyl acetal
FL/FR
ivy dioxolane
FR
neryl butyrate
FL/FR
herbal
benzyl octanoate
FL/FR
mushroom
(S)-(+)-2-
heptanol
FL/FR
3-
octen-2-ol
FL/FR
oily
amyl laurate
FL/FR
butter acids
FL/FR
petal pyranone
FL/FR
soapy
ethyl undecanoate
FL/FR
sulfurous
O-
methyl S-1-methoxyhexan-3-yl carbonothioate
FL/FR
sweet
vanilla oleoresin bali
FL/FR
tonka
6-
amyl-alpha-pyrone
FL/FR
mint lactone
FL/FR
tropical
delta-
dodecalactone
FL/FR
glyceryl 5-hydroxydodecanoate
FL/FR
vanilla
ortho-
dimethyl hydroquinone
FL/FR
ethyl vanillin
FL/FR
ethyl vanillin isobutyrate
FL/FR
ethyl vanillin propylene glycol acetal
FL/FR
vanillin
FL/FR
vanillyl acetate
FL/FR
vanillyl isobutyrate
FL/FR
vanillylidene acetone
FL/FR
vegetable
methional
FL/FR
waxy
allyl nonanoate
FL/FR
iso
amyl decanoate
FL/FR
(Z)-4-
decen-1-ol
FL/FR
9-
decenoic acid
FL/FR
ethyl palmitate
FL/FR
heptyl octanoate
FL/FR
2-
methyl heptanoic acid
FL/FR
methyl laurate
FL/FR
methyl undecanoate
FR
2-
nonanol
FL/FR
octyl 2-methyl butyrate
FL/FR
octyl isobutyrate
FL/FR
phenethyl octanoate
FL/FR
propyl decanoate
FL/FR
delta-
tetradecalactone
FL/FR
2-
tridecanone
FL/FR
undecanoic acid
FL/FR
winey
2-
hexanol
FL/FR
woody
nopyl aldehyde
FR
For Flavor
No flavor group found for these
allyl cyclohexyl butyrate
FL/FR
allyl cyclohexyl hexanoate
FL/FR
allyl methyl trisulfide
FL
amyl laurate
FL/FR
benzyl octanoate
FL/FR
2-
butyl thiophene
FL
iso
butyl undecylenate
FL/FR
cocos nucifera water
FL
cyclohexyl cinnamate
FL/FR
(R)-gamma-
decalactone
FL/FR
(S)-delta-
decalactone
FL/FR
(S)-gamma-
decalactone
FL/FR
(Z)-4-
decen-1-ol
FL/FR
6-
decenoic acid
FL
decyl propionate
FL/FR
ortho-
dimethyl hydroquinone
FL/FR
(S)-gamma-
dodecalactone
FL/FR
epsilon-
dodecalactone
FL/FR
delta-2-
dodecenolactone
FL/FR
dodecyl butyrate
FL/FR
dodecyl isobutyrate
FL/FR
2,3-
epoxyoctanal
FL
ethyl 5-hydroxyoctanoate
FL/FR
farnesyl acetone
FL/FR
(S)-(+)-2-
heptanol
FL/FR
(R)-(-)-2-
heptanol
FL/FR
(Z)-3-
hepten-1-ol
FL/FR
(E)-2-
hepten-1-yl acetate
FL/FR
2-
hexanol
FL/FR
3-
methyl-2-cyclopenten-1-one
FL
4-
methyl-2-pentenoic acid
FL
3,5-
octadien-2-one
FL
octyl heptanoate
FL/FR
oenanthic ether
FL
perilla seed oil
FL/FR
propyl decanoate
FL/FR
valeraldehyde diethyl acetal
FL
iso
valeraldehyde diethyl acetal
FL/FR
acidic
acidic
(E)-2-
hexenoic acid
FL
aldehydic
acetyl nonyryl
FL/FR
amber
iso
butyl benzyl carbinol
FL/FR
balsamic
amyl cinnamate
FL/FR
vanillylidene acetone
FL/FR
bitter
(E,Z,Z)-2,4,7-
tridecatrienal
FL/FR
brown
2-oxo
butyric acid
FL/FR
buttery
butyl laevo-lactate
FL/FR
diacetyl
FL
cabbage
methyl 2-thiofuroate
FL
caramellic
strawberry furanone acetate
FL/FR
coconut
delta-
decalactone
FL/FR
(R)-
massoia lactone
FL
6-
methyl coumarin
FL
coffee
furfuryl mercaptan
FL/FR
creamy
acetoin
FL/FR
acetyl butyryl
FL/FR
acetyl isobutyryl
FL/FR
6-
amyl-alpha-pyrone
FL/FR
butter esters
FL/FR
butyl butyryl lactate
FL/FR
creamy lactone
FL/FR
divanillin
FL
delta-
dodecalactone
FL/FR
glyceryl 5-hydroxydodecanoate
FL/FR
jasmin pyranone
FL/FR
para-
methyl acetophenone
FL/FR
mint lactone
FL/FR
delta-
nonalactone
FL/FR
octyl isobutyrate
FL/FR
delta-
undecalactone
FL/FR
gamma-
undecalactone (aldehyde C-14 (so-called))
FL/FR
para-
vanillic acid
FL/FR
para-
vanillyl alcohol
FL/FR
dairy
butyl lactate
FL/FR
methyl (Z)-5-octenoate
FL/FR
earthy
1-
nonen-3-ol
FL/FR
fatty
butter acids
FL/FR
coconut absolute
FL/FR
(Z)-
dairy lactone
FL/FR
dimethyl sulfoxide
FL
(Z)-
ethyl oleate
FL/FR
ethyl undecylenate
FL/FR
4-
methyl octanoic acid
FL/FR
2,4-
octadien-1-ol
FL
(Z)-3-
octen-1-ol
FL/FR
2-
pentadecanone
FL/FR
2-
pentyl thiophene
FL
2-
tridecanone
FL/FR
2,4-
undecadienal
FL
floral
geraniol
FL/FR
fruity
acerola peach flavor
FL
acetoin acetate
FL/FR
acetyl isovaleryl
FL
allyl decanoate
FL/FR
bitter
almond oil
FL/FR
iso
amyl 2-methyl butyrate
FL/FR
butyl 2-decenoate
FL/FR
citronellyl formate
FL/FR
gamma-
decalactone
FL/FR
(E)-2-
decenoic acid
FL
ethyl lactate
FL/FR
garcinia mangostana fruit extract
FL
3-
heptyl dihydro-5-methyl-2(3H)-furanone
FL/FR
2-
hexyl-4-acetoxytetrahydrofuran
FL
methyl (E)-3-nonenoate
FL
methyl 3-nonenoate
FL/FR
phenethyl octanoate
FL/FR
3-
phenyl propyl hexanoate
FL/FR
iso
valeraldehyde
FL/FR
vanilla carboxylate
FL/FR
green
heptanal 2,3-butane diol acetal
FL
(Z)-4-
hepten-1-ol
FL/FR
(Z)-4-
heptenal
FL/FR
(E)-2-
heptenal
FL
(Z)-4-
heptenal diethyl acetal
FL/FR
3-(5-
methyl-2-furyl) butanal
FL
neryl butyrate
FL/FR
2,4-
octadienal
FL
ketonic
3-
heptanone
FL/FR
lactonic
gamma-
octalactone
FL/FR
milky
dextro,laevo-3-(
methyl thio) butanone
FL
mushroom
3-
octen-2-ol
FL/FR
nutty
arachis hypogaea fruit extract
FL
oily
2-
methyl hexanoic acid
FL/FR
petal pyranone
FL/FR
powdery
powdery ketone
FL
roasted
O-
methyl S-1-methoxyhexan-3-yl carbonothioate
FL/FR
sour
butyric acid
FL/FR
spicy
benzylidene acetone
FL
sweet
vanilla oleoresin bali
FL/FR
toasted
acetyl propionyl
FL/FR
tomato
methional
FL/FR
vanilla
ethyl vanillin
FL/FR
ethyl vanillin isobutyrate
FL/FR
ethyl vanillin propylene glycol acetal
FL/FR
vanillin
FL/FR
vanillyl acetate
FL/FR
vanillyl isobutyrate
FL/FR
waxy
allyl nonanoate
FL/FR
iso
amyl decanoate
FL/FR
9-
decenoic acid
FL/FR
ethyl palmitate
FL/FR
ethyl undecanoate
FL/FR
furfuryl octanoate
FL
heptyl octanoate
FL/FR
2-
methyl heptanoic acid
FL/FR
methyl laurate
FL/FR
2-
nonanol
FL/FR
octyl 2-furoate
FL
octyl 2-methyl butyrate
FL/FR
delta-
tetradecalactone
FL/FR
undecanoic acid
FL/FR
2-
undecanone
FL/FR
 
Potential Uses:
FRbutterscotch
FRcoconut
FRmango
FRpeach
 solvents
 
Occurrence (nature, food, other):note
 beer
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 bilberry fruit juice
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 coffee
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 guava fruit headspace reunion @ 7.60%
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 lavender oil spike spain @ 0.067%
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 mango fruit
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 pepper bell pepper fruit
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 pineapple fruit
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 wine orange wine
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 wine white wine
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Synonyms:
 agrisynth BLO
1,2-butanolide
1,4-butanolide
4-butanolide
 butyro-1,4-lactone
1,4-butyrolactone
4-butyrolactone
g-butyrolactone
 butyrolactone gamma
gamma-butyrolactone natural
 butyryl lactone
4-deoxytetronic acid
 dihydro-2(3H)-furanone
4,5-dihydro-2(3H)-furanone
 dihydrofuran-2(3H)-one
 furan-2(3H)-one, dihydro-
2(3H)-furanone, dihydro-
4-hydroxy-butanoic acid g-lactone
4-hydroxybutanoic acid lactone
gamma-hydroxybutyric acid cyclic ester
4-hydroxybutyric acid lactone
g-hydroxybutyric acid lactone
gamma-hydroxybutyric acid lactone
gamma-hydroxybutyrolactone
 oxolan-2-one
2-oxolanone
 tetrahydro-2-furanone
2,3,4,5-tetrahydro-2-furanone
 

Articles:

PubMed:Chemical composition and aroma evaluation of essential oils from Evolvulus alsinoides L.
PubMed:Catabolic pathway of gamma-caprolactone in the biocontrol agent Rhodococcus erythropolis.
PubMed:Role of roasting conditions in the profile of volatile flavor chemicals formed from coffee beans.
PubMed:Inverse gas chromatographic evaluation of the influence of soy protein on the binding of selected butter flavor compounds in a wheat soda cracker system.
PubMed:Nine new and five known polyketides derived from a deep sea-sourced Aspergillus sp. 16-02-1.
PubMed:Determination of lactones in wines by headspace solid-phase microextraction and gas chromatography coupled with mass spectrometry.
PubMed:Chemical composition and aroma evaluation of essential oils from Evolvulus alsinoides L.
PubMed:Streptogramins - two are better than one!
PubMed:Accelerated aging against conventional storage: effects on the volatile composition of chardonnay white wines.
PubMed:Impact of perceptive interactions on red wine fruity aroma.
PubMed:Comparative study of equimolar doses of gamma-hydroxybutyrate (GHB), 1,4-butanediol (1,4-BD) and gamma-butyrolactone (GBL) on catalepsy after acute and chronic administration.
PubMed:Rapid and facile detection of four date rape drugs in different beverages utilizing proton transfer reaction mass spectrometry (PTR-MS).
PubMed:Catabolic pathway of gamma-caprolactone in the biocontrol agent Rhodococcus erythropolis.
PubMed:The discriminative stimulus effects of midazolam are resistant to modulation by morphine, amphetamine, dizocilpine, and γ-butyrolactone in rhesus monkeys.
PubMed:Use of microfungi in the treatment of oak chips: possible effects on wine.
PubMed:Role of roasting conditions in the profile of volatile flavor chemicals formed from coffee beans.
PubMed:Behavioral effects of gamma-hydroxybutyrate, its precursor gamma-butyrolactone, and GABA(B) receptor agonists: time course and differential antagonism by the GABA(B) receptor antagonist 3-aminopropyl(diethoxymethyl)phosphinic acid (CGP35348).
PubMed:Enzymology of the polyenes pimaricin and candicidin biosynthesis.
PubMed:Behavioral effects and pharmacokinetics of gamma-hydroxybutyrate (GHB) precursors gamma-butyrolactone (GBL) and 1,4-butanediol (1,4-BD) in baboons.
PubMed:Production of fermentation aroma compounds by Saccharomyces cerevisiae wine yeasts: effects of yeast assimilable nitrogen on two model strains.
PubMed:Characterization of the most odor-active volatiles of orange wine made from a Turkish cv. Kozan (Citrus sinensis L. Osbeck).
PubMed:In vivo functions of the gamma-butyrolactone autoregulator receptor in Streptomyces ambofaciens producing spiramycin.
PubMed:Influence of wine turbidity on the accumulation of volatile compounds from the oak barrel.
PubMed:Inverse gas chromatographic evaluation of the influence of soy protein on the binding of selected butter flavor compounds in a wheat soda cracker system.
PubMed:GHB free acid: II. Isolation and spectroscopic characterization for forensic analysis.
PubMed:Changes in the concentration of yeast-derived volatile compounds of red wine during malolactic fermentation with four commercial starter cultures of Oenococcus oeni.
PubMed:Cloning and in vivo functional analysis by disruption of a gene encoding the gamma-butyrolactone autoregulator receptor from Streptomyces natalensis.
PubMed:Discriminative stimulus effects of gamma-hydroxybutyrate (GHB) and its metabolic precursor, gamma-butyrolactone (GBL) in rats.
PubMed:Off-vine grape drying effect on volatile compounds and aromatic series in must from Pedro Ximénez grape variety.
PubMed:Influence of reinforcer type and route of administration on gamma-hydroxybutyrate discrimination in rats.
PubMed:Effects of gamma-hydroxybutyrate (GHB) on schedule-controlled responding in rats: role of GHB and GABAB receptors.
PubMed:The role of GABAB receptors in the discriminative stimulus effects of gamma-hydroxybutyrate in rats: time course and antagonism studies.
PubMed:C75 increases peripheral energy utilization and fatty acid oxidation in diet-induced obesity.
PubMed:Volatile compounds emitted by sclerotia of Sclerotinia minor, Sclerotinia sclerotiorum, and Sclerotium rolfsii.
PubMed:Evolution of the aroma profile of sherry wine vinegars during an experimental aging in wood.
PubMed:Varietal differentiation of red wines in the Valencian region (Spain).
PubMed:Gamma-hydroxybutyrate, gamma-butyrolactone, and 1,4-butanediol: a case report and review of the literature.
PubMed:Antioxidant properties of aroma compounds isolated from soybeans and mung beans.
PubMed:Volatile compounds produced from monosodium glutamate in common food cooking.
PubMed:Coma and respiratory depression following the ingestion of GHB and its precursors: three cases.
PubMed:Direct release of the allergen tulipalin A from Alstroemeria cut flowers: a possible source of airborne contact dermatitis?
PubMed:Isolation and quantification of tuliposides and tulipalins in tulips (Tulipa) by high-performance liquid chromatography.
PubMed:Adverse events associated with ingestion of gamma-butyrolactone--Minnesota, New Mexico, and Texas, 1998-1999.
PubMed:Endogenous digoxin-like activity of mammalian-lignans and their derivatives.
PubMed:Gamma-butyrolactone's discriminability and effect on low rates of lever pressing by rats: alone and in combination with D-amphetamine and naloxone.
PubMed:Native American food and medicinal plants. 3. alpha-Methylene butyrolactone from Erythronium grandiflorum Pursh.
PubMed:Absorption of gamma-butyrolactone-gamma-carbonyl-L-histidyl-L-prolinamide citrate (DN-1417), an analog of thyrotropin-releasing hormone, in rats and dogs.
PubMed:[Anaphylactic shock to celery and sensitization to ragweed and mugwort. Crossed or concomitant allergy?].
PubMed:Dopamine analog-induced hyperglycemia in rats: involvement of the adrenal medulla and the endocrine pancreas.
PubMed:Gamma-butyrolactone increases the rate of punished lever pressing by rats.
PubMed:The effect of chronic ethanol administration on central neurotransmitter mechanisms.
PubMed:[The cancerogenic activity of gamma-butyrolactone in mice].
 
Notes:
one of the furans with a carbonyl thereby forming a cyclic lactone. it is an endogenous compound made from gamma-aminobutyrate and is the precursor of gamma-hydroxybutyrate. it is also used as a pharmacological agent and solvent. Present in morello cherry, melon, pineapple, blackberry, quince, strawberry jam, wine, soybeans, black tea, Bourbon vanilla, wheat bread, crispbread and other breads. Flavour ingredient [DFC]
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