• Indukern F&F
  • Lluch Essence
    • Lluch Essence S.L.
      A family company dedicated to sales and distribution
      Flexibility, availability, price and quality.
      Flexibility, availability, price and quality make LLUCH ESSENCE S.L. one of Europe’s references when it comes to essential oils and aroma chemicals, and it is now well known all around the world.
      Email:Info
      Voice:34 93 379 38 49
      Fax:34 93 370 65 04
      Product(s):
      gamma-BUTYROLACTONE 98% min.
       
  • M&U International
    • M&U International LLC
      Steady supply & demand
      Meeting customers increasing demands at home as well as abroad.
      M&U dedicates itself to the development and production of new products as well as continuously promoting those new products. We’ve maintained a steady supply&demand relationship with a large number of manufacturers at home and abroad. We’ve developed an extensive network and because of our relationships with these manufacturers, we’re able to provide a stable supply of great quality materials. We’re located in China’s largest communications hub, Shanghai and in the U.S. near one of the largest sea ports on the East Coast. The strategic locations of our facilities ensure convenient, prompt and secure delivery of our products to our customers. We warmly welcome your inquiries, come witness our solemn commitment for yourself.
      Email:Sales
      US Email:Sales
      Voice:+86-21-32515501 60762991 60762992
      Fax:+86-21-32515502 64204960
      US Voice:908-359-9000
      US Fax:908-359-9002
      Product(s):
      gamma-BUTYROLACTONE, Kosher
       
  • Penta International
    • Penta International Corporation
      Chemistry innovation
      At Penta, our products and services help businesses do business better.
      For over 30 years, Penta Manufacturing Company has played a growing role in worldwide chemistry innovations and applications. As an industry leader, Penta continues to pioneer chemistry-based solutions for practically every area of commerce. Our products and expertise have helped fuel technical advances in dozens of commercial applications including flavoring, coloring, fragrances and chemical processes.
      US Email:Technical Services
      US Email:Sales
      US Voice:(973) 740-2300
      US Fax:(973) 740-1839
      Product(s):
      gamma-BUTYROLACTONE, Kosher
       
  • SAFC Global
    • SAFC
      Complete Supply Chain
      The perfect blend of products and services that bring your creativity to life.
      Explore our innovative approach to providing materials and services to the development and commercial manufacturing industry. You’ll discover inspiring science, how our organization is comprised and where our future is unfolding. Our most valuable assets are our people. We understand how their commitment and dedication make us successful. We know it’s employees that help us retain our leadership position in the industry, providing quality products and services to customers across the globe.
      US Email:Sales
      US Voice:800-244-1173
      US Fax:800-368-4661
      Product(s):
      gamma-Butyrolactone ≥98%, FCC, Kosher
      MSDS
       
  • Treatt
    • Treatt PLC
      Full Range of Naturals
      World-leading, independent ingredients supplier to the flavour and fragrance industries.
      We are proud of our heritage in trading essential oils. Our founder Richard Court Treatt's charismatic and personable approach still embodies the spirit of Treatt today.
      Email:Enquiries
      US Email:Enquiries
      Voice:+44 (0) 1284 702500
      Fax:+44 (0) 1284 703809
      US Voice:+1 863 668 9500
      US Fax:+1 863 668 3388
      Product(s):
      gamma-Butyrolactone
       
gamma-butyrolactone
Notes :
one of the furans with a carbonyl thereby forming a cyclic lactone. it is an endogenous compound made from gamma-aminobutyrate and is the precursor of gamma-hydroxybutyrate. it is also used as a pharmacological agent and solvent.
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  • Organoleptics
      • Organoleptic Properties
        Odor Type :creamy
        Odor Strength :medium
        Odor Description:
        at 100.00 %. 
        creamy oily fatty caramel
        Odor Description:
        Creamy, oily with fatty nuances
        Mosciano, Gerard P&F 16, No. 2, 49, (1991)
        Taste Description:
        at 75.00 ppm.  
        Milky, creamy with fruity peach-like afternotes
        Mosciano, Gerard P&F 16, No. 2, 49, (1991)
  • Properties
      • Physical Properties
        Appearance :colorless to pale yellow clear liquid (est)
        Assay : 98.00 to 100.00 % 
        Food Chemicals Codex Listed :Yes
        Specific Gravity :1.12500 @  25.00 °C.
        Refractive Index :1.43600 @  20.00 °C.
        Melting Point : -43.30 °C. @ 760.00 mm Hg
        Boiling Point : 204.00 to  205.00 °C. @ 760.00 mm Hg
        Vapor Pressure :0.450000 mm/Hg @ 25.00 °C.
        Vapor Density :3.00 ( Air = 1 )
        Flash Point : 209.00 °F. TCC ( 98.33 °C. )
        logP (o/w) : -0.640
  • Safety
      • Safety Information
        Most important hazard(s) :Xn - Harmful.
          R 22 - Harmful if swallowed.
        R 36 - Irritating to eyes.
        R 41 - Risk of serious damage to eyes.
        S 02 - Keep out of the reach of children.
        S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
        S 36/39 - Wear suitable clothing and eye/face protection.
        Oral/Parenteral Toxicity : 
          oral-rat LD50  1540 mg/kg
        LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
        Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 31(1), Pg. 49, 1987.

        gavage-mouse LD50  1245 mg/kg
        (Schafer & Bowles, 1985)

        intraperitoneal-rat LD50  1000 mg/kg
        BEHAVIORAL: GENERAL ANESTHETIC LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
        Archivum Immunologiae et Therapiae Experimentalis. Vol. 13, Pg. 70, 1965.

        oral-mouse LD50  1460 mg/kg
        LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: GENERAL ANESTHETIC
        Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 64(2), Pg. 3, 1999.

        intraperitoneal-mouse LD50  1100 mg/kg
        BEHAVIORAL: GENERAL ANESTHETIC LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
        Archivum Immunologiae et Therapiae Experimentalis. Vol. 13, Pg. 70, 1965.

        parenteral-mouse LDLo  1600 mg/kg
        "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. Vol. 7, Pg. 687, 1955.

        intravenous-rabbit LDLo  500 mg/kg
        Archivum Immunologiae et Therapiae Experimentalis. Vol. 13, Pg. 70, 1965.

        Dermal Toxicity : 
          skin-guinea pig LD50 > 5000 mg/kg
        GAF Material Safety Data Sheet.

        Inhalation Toxicity : 
          inhalation-rat LC50 > 5100 mg/m3/4H
        National Technical Information Service. Vol. OTS0534527

  • Safety in Use
      • Safety in Use Information
        Category :flavor and fragrance agents
        Maximised Survey-derived Daily Intakes (MSDI-EU) :110.00 (μg/capita/day)
        Recommendation for gamma-butyrolactone fragrance usage levels up to :
          0.5000 % in the fragrance concentrate.
        Recommendation for gamma-butyrolactone flavor usage levels up to :
          75.0000 ppm in the finished product.
  • Safety References
      • Safety References
        European Food Safety Athority(efsa) :Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...
        European Food Safety Authority (EFSA) reference(s) :
        Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) on a request from the Commission related to - Flavouring Group Evaluation 10: Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30 - (Commission Regulation (EC) No 1565/2000 of 18 July 2000):page or pdf
        Flavouring Group Evaluation 10, Revision 1 (FGE10 Rev1)[1] - Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC):page or pdf
        Flavouring Group Evaluation 64 (FGE.64): Consideration of aliphatic acyclic diols, triols, and related substances evaluated by JECFA (57th meeting) structurally related to aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30 evaluated by EFSA in FGE.10Rev1 (EFSA, 2008ab):page or pdf
        Scientific Opinion on Flavouring Group Evaluation 92 (FGE.92): Consideration of aliphatic acyclic diols, triols, and related substances evaluated by JECFA (68th meeting) structurally related to aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones evaluated by EFSA in FGE.10Rev1 (2009):page or pdf
        Scientific Opinion on Flavouring Group Evaluation 10, Revision 2 (FGE.10Rev2): Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30:page or pdf
        EPI System :View
        Chemicalize.org :Calculate predicted properties
        IUCLID Chemical Data Sheet :View
        NIOSH International Chemical Safety Cards :search
        NLM Hazardous Substances Data Bank :Search
        Chemical Carcinogenesis Research Information System :Search
        AIDS Citations :Search
        Cancer Citations :Search
        Toxicology Citations :Search
        Carcinogenic Potency Database :Search
        EPA GENetic TOXicology :Search
        Env. Mutagen Info. Center :Search
        NLM Developmental and Reproductive Toxicity :Search
        National Toxicology Program :Search
        EPA Substance Registry Services (TSCA) :96-48-0
        WGK Germany :1
         oxolan-2-one
        DTP/NCI :4592
        Chemidplus :0000096480
        EPA/NOAA CAMEO :hazardous materials
        RTECS :96-48-0
oxolan-2-one (Click)
CAS Number : 96-48-0 187997-16-6
ESIS EC# (EINECS) :202-509-5
Beilstein Number :0105248
MDL :MFCD00005386
CoE Number :615
XlogP3 :-0.60 (est)
Molecular Weight :86.09022000
Formula :C4 H6 O2
BioActivity Summary :listing
NMR Predictor :Predict
Category :flavor and fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information :
Google Scholar : Search Google Books : Search
Google Scholar : with word "volatile"Search Google Scholar : with word "flavor"Search
Google Scholar : with word "odor"SearchPerfumer and Flavorist : Search
Google Patents : Search US Patents : Search
EU Patents : Search IBM Patents : Obtain
Pubchem Patents:Search
PubMed : SearchNCBI : Search
EFSA Update of results on the monitoring of furan levels in food : Read Report
EFSA Previous report: Results on the monitoring of furan levels in food : Read Report
EFSA Report of the CONTAM Panel on provisional findings on furan in food : Read Report
JECFA Food Flavoring :219  4-hydroxybutyric acid lactone
Flavis Number :10.006 (Old site)
EU SANCO Food Flavourings :10.006  butyro-1,4-lactone

FEMA Number :3291  4-hydroxybutyric acid lactone
FDA Mainterm : 4-HYDROXYBUTANOIC ACID LACTONE
click on the picture(s) below to
interact with the 3D model
Picture of molecule
oxolan-2-one
Synonyms :
 agrisynth BLO
1,2-butanolide
1,4-butanolide
4-butanolide
 butyro-1,4-lactone
1,4-butyrolactone
4-butyrolactone
g-butyrolactone
 butyrolactone gamma
gamma-butyrolactone natural
 butyryl lactone
4-deoxytetronic acid
 dihydro-2(3H)-furanone
4,5-dihydro-2(3H)-furanone
 dihydrofuran-2(3H)-one
 furan-2(3H)-one, dihydro-
2(3H)-furanone, dihydro-
4-hydroxy-butanoic acid g-lactone
4-hydroxybutanoic acid lactone
gamma-hydroxybutyric acid cyclic ester
4-hydroxybutyric acid lactone
g-hydroxybutyric acid lactone
gamma-hydroxybutyric acid lactone
gamma-hydroxybutyrolactone
 oxolan-2-one
2-oxolanone
 tetrahydro-2-furanone
2,3,4,5-tetrahydro-2-furanone
Soluble in :
 alcohol
 water, 1.00E+06 mg/L @ 25 °C (exp)
Stability :
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