EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

menthoxypropane diol
3-L-menthoxypropane-1,2-diol

Supplier Sponsors

Name:3-(5-methyl-2-propan-2-ylcyclohexyl)oxypropane-1,2-diol
CAS Number: 87061-04-9Picture of molecule3D/inchi
Other:163271-16-7
ECHA EINECS - REACH Pre-Reg:289-296-2
Nikkaji Web:J60.959E
XlogP3-AA:2.30 (est)
Molecular Weight:230.34782000
Formula:C13 H26 O3
NMR Predictor:Predict (works with chrome or firefox)
EFSA/JECFA Comments:
JECFA name: 3-L-Menthoxypropane-1,2-diol. Racemate.
Category:flavor and fragrance agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
JECFA Food Flavoring:1408 3-L-menthoxypropane-1,2-diol
FLAVIS Number:02.224 (Old)
DG SANTE Food Flavourings:02.224 3-(L-menthoxy)propane-1,2-diol
FEMA Number:3784 3-L-menthoxypropane-1,2-diol
FDA:No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF):87061-04-9 ; 3-L-MENTHOXYPROPANE-1,2-DIOL
 
Physical Properties:
Appearance:colorless clear liquid (est)
Assay: 99.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:0.98900 to 0.99900 @ 25.00 °C.
Pounds per Gallon - (est).: 8.229 to 8.313
Refractive Index:1.47200 to 1.47600 @ 20.00 °C.
Boiling Point: 121.00 to 125.00 °C. @ 0.25 mm Hg
Boiling Point: 361.00 to 362.00 °C. @ 760.00 mm Hg
Acid Value: 1.00 max. KOH/g
Flash Point: 343.00 °F. TCC ( 172.78 °C. )
logP (o/w): 2.625 (est)
Soluble in:
 alcohol
 water, very slightly
 water, 108.1 mg/L @ 25 °C (est)
Insoluble in:
 water
 
Organoleptic Properties:
Odor Type: minty
Odor Strength:medium
minty vanilla
Odor Description:at 100.00 %. minty vanilla
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: masking agents
refreshing agents
 
Suppliers:
Apple Flavor & Fragrance
Cooling agent MOPD
BeYonde
Coolact Agent 10 (MOPD)
BOC Sciences
For experimental / research use only.
3-[[5-Methyl-2-(1-methylethyl)cyclohexyl]oxy]propane-1,2-diol
Jinan Enlighten Chemical Technology(Wutong Aroma )
3-L-Menthoxypropane-1,2-diol, Kosherk
Lipo Chemicals
Coolact® 10
Odor: characteristic
Use: Coolact® 10 is a sensory agent that provides a cooling effect to the skin. The product functions by directly stimulating the receptors at the nerve endings of the skin to produce a cooling sensation. Coolact® 10 provides a long lasting cooling effect.
OQEMA
Lansense 10
Parchem
menthoxypropane diol
Penta International
3-1-MENTHOXYPROPANE-1,2-DIOL
Shanghai Vigen Fine Chemical
3-l-(p-menthan-3-yloxy)-1,2-propanediol
(Cooling Agent 10 )
Takasago
Coolact 10
The Fragrance Museum
The Ingredient House
RightCool™ Cooler 10
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: flavor and fragrance agents
Recommendation for menthoxypropane diol usage levels up to:
  3.0000 % in the fragrance concentrate.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 4.10 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 789.00 (μg/capita/day)
Structure Class: I
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 16
 average usual ppmaverage maximum ppm
baked goods: --
beverages(nonalcoholic): 300.00000500.00000
beverages(alcoholic): 300.00000500.00000
breakfast cereal: --
cheese: --
chewing gum: 3000.000004000.00000
condiments / relishes: --
confectionery froastings: 100.00000500.00000
egg products: --
fats / oils: --
fish products: --
frozen dairy: --
fruit ices: --
gelatins / puddings: 500.000001000.00000
granulated sugar: --
gravies: --
hard candy: 500.00000500.00000
imitation dairy: 100.00000500.00000
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: 100.00000500.00000
soups: --
sugar substitutes: --
sweet sauces: --
 
Safety References:
European Food Safety Athority(efsa):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Flavouring Group Evaluation 23, Revision 1 (FGE.23Rev1): Aliphatic, alicyclic and aromatic ethers including anisole derivatives from chemical groups 15, 16, 26 and 30[1] - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food
View page or View pdf

Flavouring Group Evaluation 9, Revision 1: (FGE.09 Rev1)[1] - Secondary alicyclic saturated and unsaturated alcohols, ketones and esters containing secondary alicyclic alcohols from chemical groups 8 and 30, and an ester of a phenol carboxylic acid from chemical group 25 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food
View page or View pdf

Flavouring Group Evaluation 9, Revision 2 (FGE.09Rev2): Secondary alicyclic saturated and unsaturated alcohols, ketones and esters containing secondary alicyclic alcohols from chemical group 8 and 30, and an ester of a phenol derivative from chemical group 25
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 96 (FGE.96): Consideration of 88 flavouring substances considered by EFSA for which EU production volumes / anticipated production volumes have been submitted on request by DG SANCO. Addendum to FGE. 51, 52, 53, 54, 56, 58, 61, 62, 63, 64, 68, 69, 70, 71, 73, 76, 77, 79, 80, 83, 84, 85 and 87.
View page or View pdf

EPI System: View
EPA Substance Registry Services (TSCA):87061-04-9
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :5362595
National Institute of Allergy and Infectious Diseases:Data
3-(5-methyl-2-propan-2-ylcyclohexyl)oxypropane-1,2-diol
Chemidplus:0087061049
 
References:
Leffingwell:Chirality or Article
 3-(5-methyl-2-propan-2-ylcyclohexyl)oxypropane-1,2-diol
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:87061-04-9
Pubchem (cid):5362595
Pubchem (sid):135279774
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
HMDB (The Human Metabolome Database):HMDB36133
FooDB:FDB014982
ChemSpider:View
Wikipedia:View
RSC Learn Chemistry:View
 
Potential Blenders and core components note
For Odor
No odor group found for these
camel grass oil
FR
cyclopentanone
FL/FR
laevo-mono
menthyl glutarate
FL/FR
laevo-
menthyl methyl ether
FL/FR
pinocarvone
FL/FR
aldehydic
aldehydic
iso
butyraldehyde
FL/FR
camphoreous
dextro-
camphor
FL/FR
camphor tree bark oil
FL/FR
herbal ethanone
FR
thujyl alcohol
FL/FR
citrus
ocimene quintoxide
FL/FR
earthy
3-
octanol
FL/FR
patchouli cyclohexanol
FR
floral
citronellal diisotridecyl acetal
FR
cyclohexyl ethyl acetate
FL/FR
cyclohexyl propanol
FR
2-
decalinol
FR
dihydrocarvyl acetate
FL/FR
2',4'-
dimethyl acetophenone
FL/FR
earthy indane
FR
floral methanol
FR
geranium oil china
FL/FR
menthadienyl formate
FR
muguet butanol
FR
ylang ylang flower oil
FL/FR
ylang ylang flower oil CO2 extract
FL/FR
ylang ylang flower oil I
FL/FR
ylang ylang flower oil II
FL/FR
ylang ylang flower oil III
FL/FR
fruity
2-
cyclopentyl cyclopentanone
FL/FR
lilac lactone
FL/FR
green
geranium absolute
FL/FR
thiogeraniol
FL/FR
herbal
barosma betulina leaf oil
FL/FR
1,4-
cineole
FL/FR
dehydroxylinalool oxide
FL/FR
iso
dihydrolavandulol
FR
(Z)-iso
dihydrolavandulyl acetate
FR
herbal undecanol
FR
hyssop oil
FL/FR
para-
menthane-3,8-diol
FL/FR
myrtenol
FL/FR
perillaldehyde
FL/FR
pine hexanol
FR
D-(+)-alpha-
pinene
FL/FR
piperitone
FL/FR
rosemary absolute
FL/FR
rosemary oil morocco
FL/FR
sabinene hydrate
FL/FR
viridiflorol
FL/FR
licorice
sweet
basil oleoresin
FL/FR
mentholic
cornmint oil
FL/FR
cornmint oil india
FL/FR
cornmint oil terpeneless
FL/FR
(±)-
menthol
FL/FR
dextro-neo
menthol
FL/FR
laevo-
menthol
FL/FR
dextro,laevo-
menthol
FL/FR
(±)-iso
menthone
FL/FR
menthyl acetate
FL/FR
laevo-
menthyl acetate
FL/FR
menthyl acetate racemic
FL/FR
peppermint cyclohexanone
FL/FR
dextro-
piperitone
FL/FR
minty
agathosma crenulata leaf oil
FL/FR
laevo-
carveol
FL/FR
laevo-
carvone
FL/FR
carvone
FL/FR
carvyl propionate
FL/FR
cyclohexanone
FR
dihydrocarveol
FL/FR
diosphenol
FL/FR
bitter
fennel seed oil
FR
mentha longifolia oil
FR
dextro-2,8-para-
menthadien-1-ol
FL/FR
trans-para-2,8-1-
menthadienol
FL/FR
trans-para-
menthan-2-one
FL/FR
homo
menthol
FL/FR
(-)-
menthone
FL/FR
homo
menthyl acetate
FL/FR
2-
methyl cyclohexanone
FL/FR
pennyroyal oil
FL/FR
pennyroyal oil cuba
FL/FR
pennyroyal oil spain
FL/FR
pennyroyal oil uruguay
FL/FR
peppermint oil CO2 extract
FL/FR
peppermint oil idaho
FL/FR
peppermint oil terpeneless
FL/FR
beta-
phellandrene
FL/FR
piperitenone
FL/FR
laevo-
piperitone
FL/FR
iso
propyl tiglate
FL/FR
(-)-iso
pulegol
FL/FR
iso
pulegone
FL/FR
(R)-(+)-
pulegone
FR
iso
pulegyl formate
FL/FR
spearmint absolute
FL/FR
spearmint oil america
FL/FR
spearmint oil terpeneless
FL/FR
tetrahydrocarvone
FL/FR
wintergreen oil
FL/FR
WS-23
FL/FR
pine
plectranthus glandulosus hook f. leaf oil cameroon
FR
spicy
N,N-
diethyl octanamide
FR
laevo-
verbenone
FL/FR
sulfurous
buchu mercaptan
FL/FR
tropical
beta-
cyclocitral
FL/FR
woody
para-tert-
butyl cyclohexanone
FR
For Flavor
No flavor group found for these
laevo-
carveol
FL/FR
carvone
FL/FR
carvyl propionate
FL/FR
cyclopentanone
FL/FR
2-
cyclopentyl cyclopentanone
FL/FR
2',4'-
dimethyl acetophenone
FL/FR
(±)-N,N-
dimethyl menthyl succinamide
FL
diosphenol
FL/FR
lilac lactone
FL/FR
limonen-10-yl acetate
FL
dextro-2,8-para-
menthadien-1-ol
FL/FR
cis+trans-para-1(7)8-
menthadien-2-yl acetate
FL
trans-para-2,8-1-
menthadienol
FL/FR
para-
menthane-3,8-diol
FL/FR
3-laevo-
menthoxy-2-methyl propane-1,2-diol
FL
menthyl acetate racemic
FL/FR
laevo-mono
menthyl glutarate
FL/FR
laevo-
menthyl methyl ether
FL/FR
menthyl propylene glycol carbonate
FL
2-
methyl cyclohexanone
FL/FR
beta-
phellandrene
FL/FR
(Z,Z)-
photocitral A
FL
D-(+)-alpha-
pinene
FL/FR
pinocarvone
FL/FR
piperitenone
FL/FR
piperitenone oxide
FL
iso
pulegone
FL/FR
iso
pulegyl formate
FL/FR
laevo-
verbenone
FL/FR
viridiflorol
FL/FR
thujyl alcohol
FL/FR
aldehydic
aldehydic
iso
butyraldehyde
FL/FR
camphoreous
camphor tree bark oil
FL/FR
coffee
2-iso
propyl pyrazine
FL
cooling
1,4-
cineole
FL/FR
dextro,laevo-
menthol
FL/FR
laevo-
menthol
FL/FR
homo
menthyl acetate
FL/FR
menthyl acetate
FL/FR
sabinene hydrate
FL/FR
WS-5
FL
floral
dihydrocarvyl acetate
FL/FR
geranium oil china
FL/FR
ylang ylang flower oil
FL/FR
ylang ylang flower oil CO2 extract
FL/FR
ylang ylang flower oil I
FL/FR
ylang ylang flower oil II
FL/FR
ylang ylang flower oil III
FL/FR
green
cyclohexyl ethyl acetate
FL/FR
dihydrocarveol
FL/FR
geranium absolute
FL/FR
ocimene quintoxide
FL/FR
iso
propyl tiglate
FL/FR
herbal
2-
acetoxy-1,8-cineole
FL
barosma betulina leaf oil
FL/FR
hyssop oil
FL/FR
rosemary absolute
FL/FR
rosemary oil morocco
FL/FR
licorice
sweet
basil oleoresin
FL/FR
meaty
2-
methyl 3-(methyl thio) furan
FL
medicinal
dextro-
camphor
FL/FR
mentholic
cornmint oil
FL/FR
cornmint oil terpeneless
FL/FR
(±)-
menthol
FL/FR
dextro-neo
menthol
FL/FR
peppermint cyclohexanone
FL/FR
minty
agathosma crenulata leaf oil
FL/FR
laevo-
carvone
FL/FR
cornmint oil india
FL/FR
trans-para-
menthan-2-one
FL/FR
homo
menthol
FL/FR
(±)-iso
menthone
FL/FR
(-)-
menthone
FL/FR
laevo-
menthyl acetate
FL/FR
myrtenol
FL/FR
pennyroyal oil
FL/FR
pennyroyal oil cuba
FL/FR
pennyroyal oil spain
FL/FR
pennyroyal oil uruguay
FL/FR
peppermint oil CO2 extract
FL/FR
peppermint oil idaho
FL/FR
peppermint oil terpeneless
FL/FR
dextro-
piperitone
FL/FR
piperitone
FL/FR
laevo-
piperitone
FL/FR
(-)-iso
pulegol
FL/FR
spearmint absolute
FL/FR
spearmint oil america
FL/FR
spearmint oil terpeneless
FL/FR
tetrahydrocarvone
FL/FR
thiogeraniol
FL/FR
wintergreen oil
FL/FR
WS-23
FL/FR
musty
3-
octanol
FL/FR
spicy
perillaldehyde
FL/FR
sulfurous
buchu mercaptan
FL/FR
tropical
beta-
cyclocitral
FL/FR
woody
dehydroxylinalool oxide
FL/FR
 
Potential Uses:
FRmint
 refreshing agents
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 coolact 10
 cooling agent moMOPDpd
 cooling agent no. 10
3-L-(p-menthan-3-yl oxy)-1,2-propane diol
3-L-(para-menthan-3-yl oxy)-1,2-propane diol
3-L-(p-menthan-3-yloxy)-1,2-propanediol
3-L-(para-menthan-3-yloxy)-1,2-propanediol
3-L-(p-menthane-3-yl oxy)-1,2-propane diol
3-L-(para-menthane-3-yl oxy)-1,2-propane diol
3-L-(p-menthane-3-yloxy)-1,2-propanediol
3-L-(para-menthane-3-yloxy)-1,2-propanediol
3-(L-menthoxy) propane-1,2-diol
3-(L-menthoxy)propane-1,2-diol
3-1-menthoxypropane-1,2-diol
3-L-menthoxypropane-1,2-diol
 menthoxypropanediol
3-((L-menthyl)oxy)propane-1,2-diol
3-((5-methyl-2-(1-methyl ethyl)cyclohexyl)oxy)-1,2-propane diol
3-((5-methyl-2-(1-methylethyl)cyclohexyl)oxy)-1,2-propandiol
3-((5-methyl-2-(1-methylethyl)cyclohexyl)oxy)-1,2-propanediol
3-((5-methyl-2-(1-methylethyl)cyclohexyl)oxy)propane-1,2-diol
3-(5-methyl-2-propan-2-ylcyclohexyl)oxypropane-1,2-diol
1,2-propanediol, 3-((5-methyl-2-(1-methylethyl)cyclohexyl)oxy)-
1,2-propanediol, 3-[[5-methyl-2-(1-methylethyl)cyclohexyl]oxy]-
3-[(2-isopropyl-5-methylcyclohexyl)oxy]propane-1,2-diol
 rightcool cooler 10
 

Articles:

PubMed:A randomized, investigator-blinded efficacy assessment study of stand-alone emollient use in mild to moderately severe atopic dermatitis flares.
PubMed:Allergic contact dermatitis caused by menthoxypropanediol in a lip cosmetic.
PubMed:Comparison of skin permeation enhancement by 3-l-menthoxypropane-1,2-diol and l-menthol: the permeation of indomethacin and antipyrine through Yucatan micropig skin and changes in infrared spectra and X-ray diffraction patterns of stratum corneum.
 
Notes:
Physiol. cooling agent used in food and beverages
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