EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

alpha-angelica lactone
4-hydroxy-3-pentenoic acid lactone

Sponsors

Name:5-methyl-3H-furan-2-one
CAS Number: 591-12-8Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:209-701-8
FDA UNII:29CRF6L9C5
Nikkaji Web:J13.666B
Beilstein Number:0108394
MDL:MFCD00005375
CoE Number:731
XlogP3-AA:0.60 (est)
Molecular Weight:98.10122000
Formula:C5 H6 O2
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:flavor and fragrance agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
JECFA Food Flavoring:221 4-hydroxy-3-pentenoic acid lactone
FLAVIS Number:10.012 (Old)
DG SANTE Food Flavourings:10.012 5-methylfuran-2(3H)-one
FEMA Number:3293 alpha-angelica lactone
FDA:No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm: 4-HYDROXY-3-PENTENOIC ACID LACTONE
 
Physical Properties:
Appearance:white crystals (est)
Assay: 98.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:1.08800 to 1.11000 @ 25.00 °C.
Pounds per Gallon - (est).: 9.053 to 9.236
Refractive Index:1.44000 to 1.46000 @ 20.00 °C.
Melting Point: 18.00 to 20.00 °C. @ 760.00 mm Hg
Boiling Point: 55.00 to 56.00 °C. @ 12.00 mm Hg
Boiling Point: 167.00 to 170.00 °C. @ 760.00 mm Hg
Vapor Pressure:0.023000 mm/Hg @ 25.00 °C. (est)
Flash Point: 155.00 °F. TCC ( 68.33 °C. )
logP (o/w): 0.236 (est)
Shelf Life: 12.00 month(s) or longer if stored properly.
Storage:store in cool, dry place in tightly sealed containers, protected from heat and light.
Soluble in:
 alcohol
 water, 5.00E+04 mg/L @ 15 °C (exp)
Insoluble in:
 water
Similar Items:note
beta-angelica lactone
 
Organoleptic Properties:
Odor Type: coconut
Odor Strength:medium ,
recommend smelling in a 10.00 % solution or less
Substantivity: > 356 hour(s) at 100.00 %
sweet solvent nutty tonka coumarinic tobacco
Odor Description:at 10.00 % in dipropylene glycol. sweet solvent nutty tonka coumarin tobacco
Luebke, William tgsc, (1996)
Odor sample from: Sigma-Aldrich
sweet solvent oily coconut nutty coumarinic tobacco
Odor Description:Sweet, solvent-like, oily, coconut, nutty with coumarin, tobacco nuances
Mosciano, Gerard P&F 15, No. 2, 69, (1990)
Flavor Type: creamy
sweet creamy coconut vanilla hay coumarinic
Taste Description: at 100.00 ppm. Sweet, creamy, coconut, vanilla hay and coumarin-like nuances
Mosciano, Gerard P&F 15, No. 2, 69, (1990)
Odor and/or flavor descriptions from others (if found).
Takasago
Angelica Lactone Alpha ≥98%
Odor Description:Sweet-herbaceous
Used in oral care formulations to round out mint notes and in coffee flavors.
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: perfuming agents
 
Suppliers:
Advanced Biotech
ANGELICA LACTONE NATURAL
90% min. (mixed isomers)
Odor: Tobacco
Alfrebro
alpha-ANGELICA LACTONE
BOC Sciences
For experimental / research use only.
alpha-Angelica Lactone >97.0%(GC)
Diffusions Aromatiques
ALPHA LACTONE
Frutarom
ALPHA-ANGELICA LACTONE
Lluch Essence
alpha-ANGELICA LACTONE
Penn A Kem
a-Angelica Lactone
Penta International
a-ANGELICALACTONE, Kosher
Penta International
a-ANGELICALACTONE, NATURAL, Kosher, Halal
Phoenix Aromas & Essential Oils
Alpha-Angelica Lactone
Santa Cruz Biotechnology
For experimental / research use only.
a-Angelica Lactone
Sigma-Aldrich
a-Angelica lactone, 98%, FG
Odor: oily; nutty
Certified Food Grade Products
Soda Aromatic
alpha-Angelica Lactone
Synerzine
alpha-Angelicalactone
Takasago
Angelica Lactone Alpha
≥98%
Odor: Sweet-herbaceous
Use: Used in oral care formulations to round out mint notes and in coffee flavors.
The Fragrance Museum
TCI AMERICA
For experimental / research use only.
alpha-Angelicalactone >98.0%(GC)
Treatt
Angelica lactone
NI, Kosher
 
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
None - None found.
S 02 - Keep out of the reach of children.
S 24/25 - Avoid contact with skin and eyes.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 3900 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE LUNGS, THORAX, OR RESPIRATION: DYSPNEA
National Technical Information Service. Vol. OTS0571138

gavage-mouse LD50 [sex: M,F] 2800 mg/kg
(Moran et al., 1980)

intraperitoneal-mouse LD50 3000 mg/kg
Acta Pharmacologica et Toxicologica. Vol. 2, Pg. 109, 1946.

oral-mouse LD50 2800 mg/kg
Drug and Chemical Toxicology. Vol. 3, Pg. 249, 1980.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: flavor and fragrance agents
Recommendation for alpha-angelica lactone usage levels up to:
  0.5000 % in the fragrance concentrate.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 300.00 (μg/capita/day)
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 5
 average usual ppmaverage maximum ppm
baked goods: -4.00000
beverages(nonalcoholic): --
beverages(alcoholic): --
breakfast cereal: -2.00000
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: -0.20000
fruit ices: -0.20000
gelatins / puddings: -2.00000
granulated sugar: --
gravies: -2.00000
hard candy: -2.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: -2.00000
milk products: -0.20000
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: -2.00000
sugar substitutes: --
sweet sauces: --
 
Safety References:
European Food Safety Athority(efsa):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) on a request from the Commission related to - Flavouring Group Evaluation 10: Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30 - (Commission Regulation (EC) No 1565/2000 of 18 July 2000)
View page or View pdf

Flavouring Group Evaluation 10, Revision 1 (FGE10 Rev1)[1] - Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC)
View page or View pdf

Flavouring Group Evaluation 64 (FGE.64): Consideration of aliphatic acyclic diols, triols, and related substances evaluated by JECFA (57th meeting) structurally related to aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30 evaluated by EFSA in FGE.10Rev1 (EFSA, 2008ab)
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 92 (FGE.92): Consideration of aliphatic acyclic diols, triols, and related substances evaluated by JECFA (68th meeting) structurally related to aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones evaluated by EFSA in FGE.10Rev1 (2009)
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 10, Revision 2 (FGE.10Rev2): Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30
View page or View pdf

EPI System: View
Chemical Carcinogenesis Research Information System:Search
Env. Mutagen Info. Center:Search
EPA Substance Registry Services (TSCA):591-12-8
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :11559
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
5-methyl-3H-furan-2-one
Chemidplus:0000591128
RTECS:LU5075000 for cas# 591-12-8
 
References:
 5-methyl-3H-furan-2-one
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:591-12-8
Pubchem (cid):11559
Pubchem (sid):134977084
Pherobase:View
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS):View
CHEBI:View
CHEMBL:View
HMDB (The Human Metabolome Database):HMDB29609
FooDB:FDB000776
Export Tariff Code:2932.20.5050
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
RSC Learn Chemistry:View
EFSA Update of results on the monitoring of furan levels in food:Read Report
EFSA Previous report: Results on the monitoring of furan levels in food:Read Report
EFSA Report of the CONTAM Panel on provisional findings on furan in food:Read Report
 
Potential Blenders and core components note
For Odor
bready
coffee furanone
FL/FR
furfural
FL/FR
caramellic
maltol
FL/FR
shoyu furanone
FL/FR
toffee furanone
FL/FR
coconut
coconut decanone methyl
FR
coconut naphthalenone
FL/FR
delta-
decalactone
FL/FR
gamma-
heptalactone
FL/FR
hexahydrocoumarin
CS
gamma-
octalactone
FL/FR
coumarinic
phthalide
FL/FR
creamy
delta-
tridecalactone
FL/FR
waxy lactone
FL/FR
fatty
7-
decen-4-olide
FL/FR
floral
(-)-alpha-
bisabolol
FL/FR
para-
cresyl laurate
FL/FR
fruity
methyl (Z)-5-octenoate
FL/FR
tolualdehydes (mixed o,m,p)
FL/FR
gamma-
undecalactone (aldehyde C-14 (so-called))
FL/FR
green
3-
hepten-2-one
FL/FR
musk
iso
ambrettolide
FL/FR
musty
2-
acetyl pyrrole
FL/FR
nutty
filbert pyrazine
FL/FR
2,6-
lutidine
FL/FR
popcorn
2-
acetyl pyrazine
FL/FR
tobacco
deertongue absolute replacer
FR
tonka
6-
amyl-alpha-pyrone
FL/FR
gamma-
hexalactone
FL/FR
7-
methyl coumarin
CS
mint lactone
FL/FR
octahydrocoumarin
FL/FR
whiskey lactone
FL/FR
yeasty
laevo-
glutamic acid
CS
For Flavor
No flavor group found for these
(-)-alpha-
bisabolol
FL/FR
coconut naphthalenone
FL/FR
7-
decen-4-olide
FL/FR
fig leaf absolute
FL
3-
pentanol
FL
bready
bready
2-
propionyl thiazole
FL
brown
furfural
FL/FR
burnt
furfuryl alcohol
FL
caramellic
maltol
FL/FR
shoyu furanone
FL/FR
toffee furanone
FL/FR
cocoa
butyraldehyde
FL
coconut
delta-
decalactone
FL/FR
massoia bark oil CO2 extract
FL
(R)-
massoia lactone
FL
6-
methyl coumarin
FL
octahydrocoumarin
FL/FR
coffee
diisoamyl thiomalate
FL
corn chip
2-
acetyl-2-thiazoline
FL
coumarinic
phthalide
FL/FR
creamy
6-
amyl-alpha-pyrone
FL/FR
5,5-
dibutyl dihydrofuran-2(3H)-one
FL
dihydrocoumarin
FL
3-
hepten-2-one
FL/FR
gamma-
hexalactone
FL/FR
massoia lactone
FL
mint lactone
FL/FR
delta-
tridecalactone
FL/FR
gamma-
undecalactone (aldehyde C-14 (so-called))
FL/FR
waxy lactone
FL/FR
dairy
methyl (Z)-5-octenoate
FL/FR
fruity
banana coconut cream flavor
FL
tolualdehydes (mixed o,m,p)
FL/FR
lactonic
gamma-
heptalactone
FL/FR
gamma-
octalactone
FL/FR
metallic
2,5-
dihydroxy-1,4-dithiane
FL
musk
iso
ambrettolide
FL/FR
nutty
2-
acetyl pyrrole
FL/FR
coffee furanone
FL/FR
filbert pyrazine
FL/FR
2,6-
lutidine
FL/FR
roasted
2-
acetyl pyrazine
FL/FR
waxy
para-
cresyl laurate
FL/FR
furfuryl octanoate
FL
woody
whiskey lactone
FL/FR
 
Potential Uses:
 chocolate cocoa
FRcoconut
FRcoffee
FRcream
FLmilk
FLmolasses
FLnut
FRtobacco
FRtonka bean
FRvanilla
 
Occurrence (nature, food, other):note
 almond seed
Search Trop Picture
 bread white bread
Search PMC Picture
 coffee
Search PMC Picture
 grape
Search Trop Picture
 hazelnut
Search Trop Picture
 licorice
Search Trop Picture
 malt
Search PMC Picture
 peanut
Search Trop Picture
 popcorn
Search PMC Picture
 soybean
Search Trop Picture
 
Synonyms:
a-angelic lactone
a-angelica lactone
alpha-angelica lactone
delta(2)-angelica lactone
delta(sup 2)-angelica lactone
 angelica lactone natural
a-angelicalactone
alpha-angelicalactone
a-angelicalactone naturalal
 furan-2(3H)-one, 2,3-dihydro-5-methyl-
2(3H)-furanone, 5-methyl-
4-hydroxy-3-pentenoic acid g-lactone
4-hydroxy-3-pentenoic acid lactone
4-hydroxypent-3-enoic acid lactone
5-methyl furan-2(3H)-one
5-methyl furanone
5-methyl-2,(3H)-furanone
5-methyl-2(3H)-furanone
5-methyl-2[3H]-furanone
5-methyl-3H-furan-2-one
g-methyl-b,g-crotonolactone
gamma-methyl-beta,gamma-crotonolactone
5-methylfuran-2(3H)-one
3-pentenoic acid, 4-hydroxy,lactone a-angelica-lactone
 

Articles:

PubMed:Efficient, solvent-free hydrogenation of α-angelica lactone catalysed by Ru/C at atmospheric pressure and room temperature.
PubMed:Thermochemistry and kinetics of angelica and cognate lactones.
PubMed:Direct catalytic asymmetric vinylogous conjugate addition of unsaturated butyrolactones to α,β-unsaturated thioamides.
PubMed:Hydrodeoxygenation of the angelica lactone dimer, a cellulose-based feedstock: simple, high-yield synthesis of branched C7 -C10 gasoline-like hydrocarbons.
PubMed:[Comparison on content of ligustilides in different danggui samples].
PubMed:An automated dual-gradient liquid chromatography-MS/MS method for the simultaneous determination of ferulic acid, ligustrazine and ligustilide in rat plasma and its application to a pharmacokinetic study.
PubMed:Identification of multiple ingredients for a Traditional Chinese Medicine preparation (bu-yang-huan-wu-tang) by liquid chromatography coupled with tandem mass spectrometry.
PubMed:Synthesis of both enantiomers of 12-methyl-13-tridecanolide and 14-methyl-15-pentadecanolide (muscolide).
PubMed:Radix Angelica Sinensis that contains the component Z-ligustilide promotes adult neurogenesis to mediate recovery from cognitive impairment.
PubMed:[Effects of conjunctive application of Chinese herbal medicine residue compost and chemical fertilizer on ferulic acid and ligustilide contents in Angelica sinensis].
PubMed:Z-ligustilide activates the Nrf2/HO-1 pathway and protects against cerebral ischemia-reperfusion injury in vivo and in vitro.
PubMed:Effects of natural phytochemicals in Angelica sinensis (Danggui) on Nrf2-mediated gene expression of phase II drug metabolizing enzymes and anti-inflammation.
PubMed:[Study on quality evaluation of Angelica sinensis by grey incidence degree method].
PubMed:[Study on the dynamic variations of Z-ligustilide and n-butylidenephthalide content in essential oil of radix angelicae sinensis from different growth period].
PubMed:Epigenetic reactivation of Nrf2 in murine prostate cancer TRAMP C1 cells by natural phytochemicals Z-ligustilide and Radix angelica sinensis via promoter CpG demethylation.
PubMed:[Research progress studies on pharmacology and pharmacokinetics of ligustilide].
PubMed:Antioxidant properties of cis-Z,Z'-3a.7a',7a.3a'-dihydroxyligustilide on human umbilical vein endothelial cells in vitro.
PubMed:Ligustilide alleviates brain damage and improves cognitive function in rats of chronic cerebral hypoperfusion.
PubMed:Anti-inflammatory effects of Z-ligustilide nanoemulsion.
PubMed:Anti-inflammatory effects of (Z)-ligustilide through suppression of mitogen-activated protein kinases and nuclear factor-κB activation pathways.
PubMed:Targeting mTOR pathways in human malignancies.
PubMed:Bioactivity-guided fractionation of the volatile oil of Angelica sinensis radix designed to preserve the synergistic effects of the mixture followed by identification of the active principles.
PubMed:Chemometric classification of morphologically similar Umbelliferae medicinal herbs by DART-TOF-MS fingerprint.
PubMed:Asymmetric assembly of 2-oxindole and α-angelica lactone units to construct vicinal quaternary chiral centers.
PubMed:Z-ligustilide isolated from Radix Angelicae sinensis ameliorates the memory impairment induced by scopolamine in mice.
PubMed:Catalytic asymmetric vinylogous Mannich-type (AVM) reaction of nonactivated α-angelica lactone.
PubMed:Identification of novel pregnane X receptor activators from traditional Chinese medicines.
PubMed:Ligustilide prevents LPS-induced iNOS expression in RAW 264.7 macrophages by preventing ROS production and down-regulating the MAPK, NF-κB and AP-1 signaling pathways.
PubMed:Treatment with Z-ligustilide, a component of Angelica sinensis, reduces brain injury after a subarachnoid hemorrhage in rats.
PubMed:[Study on feasibility of cutting process of fresh Angelica sinensis Radix].
PubMed:Effects of ligustilide on lipopolysaccharide-induced endotoxic shock in rabbits.
PubMed:Inhibitory effects of Angelica sinensis ethyl acetate extract and major compounds on NF-kappaB trans-activation activity and LPS-induced inflammation.
PubMed:Ligustilide suppresses the biological properties of Danggui Buxue Tang: a Chinese herbal decoction composed of radix astragali and radix angelica sinensis.
PubMed:Z-ligustilide extracted from Radix Angelica Sinensis decreased platelet aggregation induced by ADP ex vivo and arterio-venous shunt thrombosis in vivo in rats.
PubMed:Optimization and comparison of five methods for extraction of coniferyl ferulate from Angelica sinensis.
PubMed:Bioactivity-guided fractionation and GC/MS fingerprinting of Angelica sinensis and Angelica archangelica root components for antifungal and mosquito deterrent activity.
PubMed:[Development of gas chromatographic-mass spectrometry-pattern recognition method for the quality control of Chinese Angelica].
PubMed:Angelica sinensis and its alkylphthalides induce the detoxification enzyme NAD(P)H: quinone oxidoreductase 1 by alkylating Keap1.
PubMed:Lead compounds for anti-inflammatory drugs isolated from the plants of the traditional oriental medicine in Korea.
PubMed:Dynamic nature of the ligustilide complex.
PubMed:Application of analytical and preparative high-speed counter-current chromatography for the separation of Z-ligustilide from a crude extract of Angelica sinensis.
PubMed:Postischemic administration of Z-Ligustilide ameliorates cognitive dysfunction and brain damage induced by permanent forebrain ischemia in rats.
PubMed:Protection against hydrogen peroxide-induced injury by Z-ligustilide in PC12 cells.
PubMed:A new procedure for the preparative separation and isolation of Z-ligustilide from the roots of Angelica sinensis.
PubMed:Fast determination of Z-ligustilide in plasma by gas chromatography/mass spectrometry following headspace single-drop microextraction.
PubMed:Ligustilide reduces phenylephrine induced-aortic tension in vitro but has no effect on systolic pressure in spontaneously hypertensive rats.
PubMed:[High performance liquid chromatography-mass spectrometry analysis of radix Angelica sciensis].
PubMed:14-Methylpentadecano-15-lactone (muscolide): a new macrocyclic lactone from the oil of Angelica archangelica L.
PubMed:Neuroprotective role of Z-ligustilide against forebrain ischemic injury in ICR mice.
PubMed:Ligustilide inhibits spontaneous and agonists- or K+ depolarization-induced contraction of rat uterus.
PubMed:Live cell extraction and HPLC-MS analysis for predicting bioactive components of traditional Chinese medicines.
PubMed:[The new progress of the study about volatile oil of the angelica].
PubMed:Optimization of pressurized liquid extraction for Z-ligustilide, Z-butylidenephthalide and ferulic acid in Angelica sinensis.
PubMed:LC-DAD-APCI-MS-based screening and analysis of the absorption and metabolite components in plasma from a rabbit administered an oral solution of danggui.
PubMed:Development of pressurized hot water extraction followed by headspace solid-phase microextraction and gas chromatography-mass spectrometry for determination of ligustilides in Ligusticum chuanxiong and Angelica sinensis.
PubMed:[Study on preparation of refined Xiong-gui sustained release pills].
PubMed:[New dimeric phthalide derivative from Angelica sinensis].
PubMed:[Isolation and identification of the ligustilide compounds from the root of Angelica sinensis].
PubMed:Induction of rat hepatic and intestinal UDP-glucuronosyltransferases by naturally occurring dietary anticarcinogens.
PubMed:Triflic anhydride mediated cyclization of 5-hydroxy-substituted pyrrolidinones for the preparation of alpha-trifluoromethylsulfonamido furans.
PubMed:Enhancement of glutathione and g-glutamylcysteine synthetase, the rate limiting enzyme of glutathione synthesis, by chemoprotective plant-derived food and beverage components in the human hepatoma cell line HepG2.
PubMed:Anti-acne effects of Oriental herb extracts: a novel screening method to select anti-acne agents.
PubMed:[Constituent analysis of essential oils from radix of Angelica acutiloba].
PubMed:The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes.
PubMed:Regulation of rat glutamate-cysteine ligase (gamma-glutamylcysteine synthetase) subunits by chemopreventive agents and in aflatoxin B(1)-induced preneoplasia.
PubMed:Effects of chemoprotective agents on the metabolic activation of the carcinogenic arylamines PhIP and 4-aminobiphenyl in human and rat liver microsomes.
PubMed:Effects of dietary anticarcinogens on rat gastrointestinal glutathione S-transferase theta 1-1 levels.
PubMed:Effects of methylenechloride-soluble fraction of Japanese angelica root extract, ligustilide and butylidenephthalide, on pentobarbital sleep in group-housed and socially isolated mice.
PubMed:Chemoprotection against the formation of colon DNA adducts from the food-borne carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in the rat.
PubMed:Ab Initio Study of Endo/Exo and Diastereofacial Selectivities in Diels-Alder Reactions between Chiral Butenolides and Cyclopentadiene.
PubMed:Enhancement of rat hepatic and gastrointestinal glutathione and glutathione S-transferases by alpha-angelicalactone and flavone.
PubMed:Quantification of induction of rat oesophageal, gastric and pancreatic glutathione and glutathione S-transferases by dietary anticarcinogens.
PubMed:Induction of rat hepatic and intestinal glutathione s-transferases and glutathione by dietary naturally-occurring anticarcinogens.
PubMed:[Studies on the antiasthmatic action of ligustilide of dang-gui, Angelica sinensis (Oliv.) Diels].
PubMed:Enhancement of glutathione S-transferase activity of the esophagus by phenols, lactones, and benzyl isothiocyanate.
PubMed:Effect of butylated hydroxyanisole, alpha-angelica lactone, and beta-naphthoflavone on benzo(alpha)pyrene:DNA adduct formation in vivo in the forestomach, lung, and liver of mice.
PubMed:Glutathione S-transferase activity: enhancement by compounds inhibiting chemical carcinogenesis and by dietary constituents.
PubMed:Enhancement of glutathione S-transferase activity of the mouse forestomach by inhibitors of Benzo[a]pyrene-induced neoplasia of the forestomach.
PubMed:Inhibition of chemical carcinogen-induced neoplasia by coumarins and alpha-angelicalactone.
PubMed:Chemical composition of angelica root oil.
PubMed:The influence of ouabain and alpha angelica lactone on calcium metabolism of dog cardiac microsomes.
PubMed:[LACTONES OF ANGELICA GENUFLEXA].
PubMed:The inhibition of ribonuclease by extract of privet leaves and by alpha-angelica lactone.
PubMed:The anti-fibrillatory action of 2-pentene 1-4-olide (alaph-beta unsaturated angelica lactone) on the electrically induced ventricular fibrillation of the cat's heart.
PubMed:[Action of beta Angelica lactone and digitalic substances on the heart of Bufo arenarum Hensel].
PubMed:[Effect of beta gamma lactones of Angelica and Digitalis on the heart of toad Bufo arenarum Hensel].
PubMed:The action of angelica lactones on the toxicity of digitoxin and on the cardiac irregularities produced by digitoxin and barium.
PubMed:[Not Available].
 
Notes:
Flavouring for baked goods, milk and meat produts
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