2-acetyl pyrazine
  • Advanced Biotech
  • Alfrebro
    • Alfrebro LLC
      Let's get reacquainted
      Building great taste with aroma chemicals, extracts, and distillates
      The Alfrebro brand was established in the early 1900s by Alex Fries & Brothers, a Cincinnati Flavor Company. In 1980, the brand was re-launched as an aroma chemical manufacturer. Since its inception, Alfrebro’s primary focus has been to provide quality natural and high value synthetic chemicals.
      Email: Sarah Forbis
      Email: Sales
      Voice: 513-539-3021
      Fax: 513-539-7372
      US Voice: 513-539-7373
  • Apiscent Labs
    • Apiscent Labs, LLC
      Delivery of Quality
      Custom manufacturer and international supplier of fine ingredients.
      We believe inspired chemistry enriches lives. That's why our team is guided by a mission to provide fine ingredients to the worldwide pharmaceutical, flavor and fragrance markets with a primary focus on the manufacturing of value-added, research-based molecules. We're innovative problem solvers committed to excellence at every phase. Our work builds the foundation for our clients' continued success.
      Email: Info
      Email: Carl Sheeley
      Email: Customer Service
      Voice: +1 (414) 744 3993
      Fax: +1 (414) 744 7111
  • Beijing Lys Chemicals
    • Beijing Lys Chemicals Co, LTD.
      From Grams to Tons
      Fine chemical high-tech company which contains R&D, production, and sales.
      BEIJING LYS CHEMICALS CO, LTD, established in 2004, is a fine chemical high-tech company which contains R&D, production, and sales. We mainly engaged in export and technology development of flavor and fragrance materials and pharmaceutical intermediates. We have nearly 500 kinds of products, from grams to tons, exported to USA, Europe, South Asia and etc. And we custom manufacture new products according to customers’ needs, and serve good quality products and service. Our goal is to become a fine chemical enterprise which could provide special products and services.
      Email: Mr. Jia
      Email: Mr. Guo
      Voice: 86-10-68418738
      Fax: 86-10-68418739
      Mr. Guo86-10-68483445
      Mr. Guo86-10-68418739
      10060 2-Acetyl pyrazine
  • Berjé
    • Berjé Inc.
      The solution is clear
      Where the world comes to its senses - Berjé is a global distributor of Essential Oils and Aromatic Chemicals.
      Berjé is a family-owned business that has been in operation for six decades. The company's origins and strength lie in a profound understanding of the supply and the quality of the diverse raw materials consumed by the flavor and fragrance industries. This base was expanded upon more than two decades ago to include fragrance production. The company's unparalleled raw material expertise is focused on the supply of essential oils and aromatic chemicals. This is supported by our long-standing relationships with a worldwide fabric of producers ensuring the greatest prospects for uninterrupted supply in markets that are often volatile and unpredictable.
      Email: For Information
      Email: For Sales
      Voice: 973-748-8980
      Fax: 973-680-9618
      Market Report
      2-Acetyl Pyrazine
  • Charkit Chemical
    • Charkit Chemical Corporation
      The Specialty Chemical Specialists
      Explore this website to discover the products and services that Charkit provides for your industry and please contact us directly to find out how we can be of service to you.
      Since 1982, Charkit has been committed to expanding the markets we serve and our roster of products and services continues to grow with us. Personal care ingredients now include a substantial array of luxury and exotic components. Substantial inroads have been made in the nutraceutical and resins markets, with a growing roster of versatile and unique ingredients. And we continue to lead the way in our traditional markets such as Metal and Water Treatment, Imaging, Flavor & Fragrance, Aroma and Food. Our Pharmaceutical offerings continue to expand, still anchored by the Boronic Derivatives that meet the demands of Suzuki coupling reactions.
      Email: Sales
      Voice: 203-299-3220
      Fax: 203-299-1355
      Products List: View
  • DeLong Chemicals America
    • DeLong Chemicals America
      Custom Manufacturing
      Supplier of aroma chemicals, pharmaceutical and specialty chemical intermediates.
      DeLong Chemicals America, LLC is an extension of Shijiazhuang Lida Chemical Co, Ltd to North America, a leading supplier and manufacturer of aroma chemicals, serving the industries of food, tobacco and perfume, while also providing intermediates, custom synthesis and custom manufacturing for pharmaceutical and specialty chemical industries.
      US Email: Customer Service
      US Email: Sales
      US Voice: (203) 271-9017
      New products
      9867 2-Acetylpyrazine, Kosher
  • Elan Inc.
    • Elan Inc.
      Legacy of Innovation
      Highest quality natural and synthetic products.
      Elan Inc. is a privately held business that has been in operation for over 30 years. Our offices and production facility are located in Newark, NJ. We are dedicated to producing the highest quality natural and synthetic products available in the flavor and fragrance industry.
      US Email: Mr. David Pimentel
      US Email: Ms. Isabel Couto
      Email: Elan (Shanghai) Fine Chemical
      Email: Elan do Brazil
      US Voice: (973) 344-8014
      US Fax: (973) 344 -5880
      Voice: +86 021 57448053 (Elan Shanghai)
      Fax: +86 021 57448054 (Elan Shanghai)
      Elan do Brazil:55 13 3261 6084
      Elan do Brazil Fax:55 13 3261 3726
      Custom Solutions
  • Endeavour Specialty Chemicals
    • Endeavour Specialty Chemicals Ltd
      Expertise in Small to Medium Scale Chemical Manufacturing
      Endeavour Speciality Chemicals offers high-impact aroma chemicals, all produced at the highest standards of quality.
      Endeavour Speciality Chemical has 25 years' experience of manufacturing high-impact aroma chemicals. With our core expertise in sulfur and heterocyclic chemistries, Endeavour's products have applications in a range of industry sectors including flavours and fragrances, pharmaceutical research and material sciences. Endeavour also offer custom synthesis and contract manufacturing services at their UK manufacturing site.
      Email: Info
      Email: Sales
      Voice: +44 (0)1327 310 079
      Fax: +44 (0)1327 310 701
      Speciality Chemical Product Groups
      PZ0010 2-Acetylpyrazine 99% F&F
  • Fleurchem
    • Fleurchem, Inc.
      Have A Flavorful Day
      A leading global manufacturer and supplier of ingredients for Flavors, Fragrances, AromaTherapy, Foods, Beverages, Personal Care Products, and other uses.
      Operating out of the 200,000 sq. ft., former Hercules/PFW facility in Middletown, NY; Fleurchem produces a full range of natural isolates, synthetic chemicals & specialities, essential oils and flavors. Additionally, the company performs toll manufacturing, as well as custom chemical synthesis for a wide range of clients.
      Email: Information
      US Voice: 845-341-2100
      US Fax: 845-341-2121
      2-acetyl pyrazine
  • Frutarom
    • Frutarom Ltd
      Discover Our Passion
      Your preferred partner for flavour and fragrance success.
      At Frutarom, we take pride in our expertise and knowledge of Flavour & Fragrance Ingredients and our thorough understanding of the needs of Flavourists, Perfumers and Food Technologists. Working closely with our customers we have a strong track record of providing unique solutions to fulfil requirements.
      US Email: Info- USA
      Email: Info - UK
      Voice: +44 (0) 1429 863 222
      US Voice: +1 513 870 4900
      Products List: View
      A0410 2-ACETYLPYRAZINE ≥99.00%, NI, Kosher
      Suggested Uses: Bread, Cocoa, Coffee, Nut, Potato
  • H. Interdonati, Inc.
    • H. Interdonati, Inc.
      Innovative products
      Because your flavors and fragrances are only as good as their source "Since 1952"
      H. Interdonati, Inc. began in 1952 with the tradition of delivering quality pharmaceuticals and fine chemical ingredients at competitive prices. The mission was simple: To provide the most reliable, personal service in the industry.
      Email: Info
      US Email: Info
      Email: Sales
      US Email: Andrew Interdonati (Sales)
      Voice: 800 367-6617
      Fax: 631 367-6626
      Featured Products
      2-acetyl pyrazine Kosher
  • Indukern F&F
  • Lluch Essence
    • Lluch Essence S.L.
      A family company dedicated to sales and distribution
      Flexibility, availability, price and quality.
      Flexibility, availability, price and quality make LLUCH ESSENCE S.L. one of Europe’s references when it comes to essential oils and aroma chemicals, and it is now well known all around the world.
      Email: Info
      Voice: 34 93 379 38 49
      Fax: 34 93 370 65 04
  • M&U International
    • M&U International LLC
      Steady supply & demand
      Meeting customers increasing demands at home as well as abroad.
      M&U dedicates itself to the development and production of new products as well as continuously promoting those new products. We’ve maintained a steady supply&demand relationship with a large number of manufacturers at home and abroad. We’ve developed an extensive network and because of our relationships with these manufacturers, we’re able to provide a stable supply of great quality materials. We’re located in China’s largest communications hub, Shanghai and in the U.S. near one of the largest sea ports on the East Coast. The strategic locations of our facilities ensure convenient, prompt and secure delivery of our products to our customers. We warmly welcome your inquiries, come witness our solemn commitment for yourself.
      Email: Sales
      US Email: Sales
      Voice: +86-21-32515501 60762991 60762992
      Fax: +86-21-32515502 64204960
      US Voice: 908-359-9000
      US Fax: 908-359-9002
      H0035 2-ACETYL PYRAZINE, Kosher
  • Penta International
    • Penta International Corporation
      Chemistry innovation
      At Penta, our products and services help businesses do business better.
      For over 30 years, Penta Manufacturing Company has played a growing role in worldwide chemistry innovations and applications. As an industry leader, Penta continues to pioneer chemistry-based solutions for practically every area of commerce. Our products and expertise have helped fuel technical advances in dozens of commercial applications including flavoring, coloring, fragrances and chemical processes.
      US Email: Technical Services
      US Email: Sales
      US Voice: (973) 740-2300
      US Fax: (973) 740-1839
      01-09900 2-ACETYLPYRAZINE FCC, Kosher
  • Phoenix Aromas & Essential Oils
    • Phoenix Aromas & Essential Oils, Inc.
      EXCEPTIONAL Flavor and Fragrance Ingredients.
      Phoenix sources the finest flavor and fragrance ingredients for its customers.
      Phoenix Aromas & Essential Oils LLC was founded in 1994, grounded in a simple set of core values: provide top-quality products, cost-effective pricing and personalized attention to all our customers. After two decades, we remain committed to those values. With extensive market knowledge of our products, we anticipate, as opposed to merely react, to industry challenges. You can rely on us for all your flavor and fragrance ingredient needs. Customers benefit from Phoenix's long-standing relationships with experienced and reputable growers, processors and manufacturers in key global locations, who are committed to sustainability and green programs. With a strategically located 80,000 sq-ft facility, customers can rely on Phoenix to deliver quality products on time, and cost-effectively.
      Email: EU Info
      US Email: Info
      US Email: Sales
      Voice: +44(0) 208 532 1022
      Fax: +44(0) 208 532 1023
      US Voice: 201-784-6100
      US Fax: 201-784-8566
      Global Reach
      Pyrazine, 2-Acetyl
  • Pyrazine Specialties
    • Pyrazine Specialties, Inc.
      Naturally Better
      First in pyazines for the food, perfume, and pharmaceutical industry.
      Pyrazine Specialties, Incorporated began almost 40 years ago in a modest little building near the Georgia Tech campus. Today, Pyrazine Specialties is looking to expand its facilities as well as significantly increase our product line.
      US Email: Customer Service
      US Email: Sales
      US Voice: (404) 524-6744
      US Fax: (404) 577-1651
      612A 2-Acetylpyrazine
  • Riverside Aromatics
    • Riverside Aromatics Ltd.
      Speciality Aroma Chemicals, Naturals and Synthetics
      Specialist raw material suppliers to the Flavour & Fragrance Industry.
      Peter Cannon & David Rowe established Riverside Aromatics in 2006 in Poole, UK, to offer a new type of specialist raw material supplier to the Flavour & Fragrance Industry. We bring together over 40 years of commercial & technical experience in the F&F industry which allows us to understand the needs of the Global F&F business and especially that of the West European Market.
      Email: Info
      Email: Peter Cannon (sales)
      Voice: +44 (0) 1202 679532
      Fax: +44 (0) 1202 679532
      Products List: View
      AP0100 2-Acetylpyrazine
  • Robinson Brothers
    • Robinson Brothers Limited
      Providing Excellence in Chemistry
      Award-winning UK chemical manufacturer of chemical intermediates and high-impact aroma chemicals.
      Based in the UK, Robinson Brothers is an award-winning chemical manufacturer of chemical intermediates and high-impact aroma chemicals. Robinson Brothers serve many industry sectors across the globe, include: flavour/fragrance, pharmaceutical, agrochemical and material sciences. Our team of Chemists are experts in custom synthesis, contract manufacture and process optimisation.
      Email: Info
      Email: Sales
      Voice: +44 (0)121 553 2451
      Fax: +44 (0)121 500 5183
      Products List: View
      PZ0010 2-Acetylpyrazine F&F
  • Sigma-Aldrich
    • Sigma-Aldrich
      Complete Supply Chain
      The perfect blend of products and services that bring your creativity to life.
      Sigma-Aldrich is a leading Life Science and High Technology company dedicated to providing high-quality, safe and certified flavor ingredients with transparent and easily accessible documentation to customers around the globe. Sigma-Aldrich also provides a suite of analytical tools that allow food analysts to simplify sample preparation, cleanup and analysis steps, while increasing sensitivity to trace ingredients and harmful substances to meet regulations and quality standards.
      Email: Information
      US Email: Sales
      US Voice: 800-244-1173
      US Fax: 800-368-4661
      Certified Food Grade Products
      W312606 2-Acetylpyrazine, ≥99%, FCC, FG
  • Sunaux International
    • Sunaux International
      Buy With Confidence
      We have industry leading processes and procedures to ensure nothing but the most reliable product.
      Sunaux International was founded in 2012 by the owner Mr.John Felton after spending 18 years involved in developing global business in the aromatic chemicals, fragrance and flavour compounds business.
      Email: John Felton
      Email: Stephen Zhou (Sales)
      Voice: 0512-57995626
      Fax: 0512-57570299
      H0035 2-Acetyl Pyrazine
  • Taytonn
      Supplying Asia Pacific
      We fully understand the demands of the F&F industry and we endeavour to supply quality products, with ready availability and a personalised service.
      Since 2001 TAYTONN has been distributing key ingredients to the Fragrance and Flavor industry in Asia. We work closely with customers, principals and vendors. Together we forecast demand and match it with supply of aroma chemicals, essential oils and natural isolates & extracts. Sourced from around the world, our F&F ingredient inventory in Singapore is ready to ship to any location in Asia and beyond. Time and again, we help our principals introduce new discoveries to the F&F market - stimulating creativity and bringing value added proposition to our customers.
      Email: Info
      Email: Sales
      Voice: + 65 - 6861 8113
      Fax: + 65 - 6861 8115
  • The Lermond Company
    • The Lermond Company
      Your Sourcing Resource
      The Lermond family has been sourcing raw materials for the flavor and fragrance industry for nearly 7 decades.
      The Lermond Company is a women-owned distributor of raw materials primarily servicing the flavor and fragrance industry. For three generations, members of the Lermond family have been integral sourcing partners for the North American flavor and fragrance industry. We supply high quality essential oils, aroma chemicals, absolutes, concretes, resinoids and floral waters from around the world to the global industry.
      Email: Info
      Email: Tara
      Email: Erica
      Voice: 201-896-3300
      Fax: 201-623-2910
      2-Acetyl Pyrazine
  • Treatt
    • Treatt PLC
      Innovative ingredient solutions
      World-leading innovative ingredient solutions provider for the flavour, fragrance and FMCG industries.
      We offer innovative and trend-setting product concepts for our customers, collaborating with them to create true value for their products.
      Email: Enquiries
      US Email: Enquiries
      Voice: +44 (0) 1284 702500
      Fax: +44 (0) 1284 703809
      US Voice: +1 863 668 9500
      US Fax: +1 863 668 3388
      2-Acetylpyrazine Halal, Kosher

      Used not only for popcorn type flavours, but also in roast nut flavours (hazelnut, peanut, almond), chocolate, bread and yeast type flavors. 2-Acetylpyrazine and 2-acetylthiazole both have aromas similar to the non-GRAS material 2-acetylpyrroline which is an important character impact compound in aromatic rice, bread crust and popcorn. Normal use levels in finished consumer product: 0.05-5 ppm. Council of Europe limits: foods (5 ppm); beverages (5 ppm).
Synonyms   Articles   Notes   Search
Fragrance Demo Formulas    Flavor Demo Formulas
1-pyrazin-2-ylethanone (Click)
CAS Number: 22047-25-2 131922-02-6
ECHA EINECS - REACH Pre-Reg: 244-753-5
Nikkaji Web: J27.905F
MDL: MFCD00006134
CoE Number: 2286
XlogP3: 0.20 (est)
Molecular Weight: 122.12702000
Formula: C6 H6 N2 O
NMR Predictor: Predict (works with chrome or firefox)
Category: flavor and fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist: Search
Google Patents: Search
US Patents: Search
EU Patents: Search
IBM Patents: Obtain
Pubchem Patents: Search
PubMed: Search
NCBI: Search
JECFA Food Flavoring: 784  2-acetylpyrazine
Flavis Number: 14.032 (Old)
DG SANTE Food Flavourings: 14.032  2-acetylpyrazine
FEMA Number: 3126  2-acetylpyrazine
Synonyms   Articles   Notes   Search   Top
Physical Properties:
Appearance: white to pale yellow crystalline powder (est)
Assay: 99.00 to 100.00 % 
Food Chemicals Codex Listed: Yes
Melting Point: 76.00 to  78.00 °C. @ 760.00 mm Hg
Boiling Point: 188.00 to  190.00 °C. @ 760.00 mm Hg
Vapor Pressure: 0.188000 mm/Hg @ 25.00 °C.
Flash Point: > 212.00 °F. TCC ( > 100.00 °C. )
logP (o/w): 0.200
Shelf Life: 24.00 month(s) or longer if stored properly.
Storage: store in cool, dry place in tightly sealed containers, protected from heat and light.
Synonyms   Articles   Notes   Search   Top
Organoleptic Properties:
Odor Type: popcorn
Odor Strength: very high ,
recommend smelling in a 0.10 % solution or less
 popcorn  nutty  corn chip  bread crust  chocolate  hazelnut  coffee  
Odor Description:
at 0.10 % in propylene glycol. 
popcorn nutty corn chip bread crust chocolate hazelnut coffee
Luebke, William tgsc, (1996)
 musty  roasted  corn chip  popcorn  nutty  potato  
Odor Description:
Musty, roasted, corn chip, popcorn, nutty and potato-like
Mosciano, Gerard P&F 17, No. 1, 41, (1992)
 roasted  nutty  bready  yeasty  popcorn  corn chip  
Taste Description:
at 10.00 ppm.  
Roasted, nutty, bready and yeasty, with popcorn and corn chip nuances
Mosciano, Gerard P&F 17, No. 1, 41, (1992)
Substantivity: 400 Hour(s)
Synonyms   Articles   Notes   Search   Top
Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: perfuming agents
Synonyms   Articles   Notes   Search   Top
Advanced Biotech
Advanced Biotech
Advanced Biotech
Advanced Biotech
Advanced Biotech
Anhui Haibei
2-Acetyl Pyrazine natural
Odor: Popcorn nutty corn chip bread crust chocolate hazelnut coffee
Anhui Haibei
2-Acetyl Pyrazine
Odor: Popcorn nutty corn chip bread crust chocolate hazelnut coffee
Anhui Suzhou Jinli Aromatic Chemicals
2-Acetyl Pyrazine
Odor: popcorn, roast
Apiscent Labs
Odor: Grilled corn, chocolate nut
Apple Flavor & Fragrance
Beijing Lys Chemicals
2-Acetyl pyrazine
2-Acetyl Pyrazine
CG Herbals
2-Acetyl Pyrazine 99%
Odor: Bread crust, Popcorn, Chocolate
Charkit Chemical
Citrus and Allied Essences
2-Acetyl Pyrazine FCC
Market Report
De Monchy Aromatics
2-Acetyl Pyrazine
Odor: nutty, chocolate, popcorn, corn chip, bread crust, hazelnut, coffee
DeLong Chemicals America
2-Acetylpyrazine, Kosher
Diffusions Aromatiques
Elan Inc.
Endeavour Specialty Chemicals
2-Acetylpyrazine 99% F&F
Speciality Chemical Product Groups
Ernesto Ventós
2-Acetyl Pyrazine
2-acetyl pyrazine
≥99.00%, NI, Kosher
Odor: Caramel, Nutty, Popcorn, Sweet
Use: Suggested Uses: Bread, Cocoa, Coffee, Nut, Potato
H. Interdonati, Inc.
2-acetyl pyrazine Kosher
Featured Products
Indukern F&F
Jiangyin Healthway
2-Acetyl Pyrazine
Jinan Enlighten Chemical Technology(Wutong Aroma )
2-Acetyl pyrazine, Kosherk
Kunshan Sainty
2-Acetyl Pyrazine ≥99.0% Kosher
Lluch Essence
M&U International
Odor: chocolate, coffee, nut, popcorn
Flavor: chocolate, popcorn in dilution (10ppm)
Pearlchem Corporation
2-Acetyl Pyrazine
Penta International
Penta International
Phoenix Aromas & Essential Oils
Pyrazine, 2-Acetyl
Pyrazine Specialties
Reincke & Fichtner
Riverside Aromatics
Odor: powerful, long-lasting and highly diffusive biscuity
Robinson Brothers
2-Acetylpyrazine F&F
Santa Cruz Biotechnology
For experimental / research use only.
2-Acetylpyrazine, ≥99%, FCC, FG
Odor: chocolate; nutty; vegetable
Certified Food Grade Products
Sunaux International
2-Acetyl Pyrazine
Odor: Sweet, Nutty, Caramellic/ Caramel, Popcorn
For experimental / research use only.
2-Acetylpyrazine >99.0%(GC)
Tengzhou Jitian Aroma Chemiclal
2-Acetyl Pyrazine
The Lermond Company
2-Acetyl Pyrazine
Halal, Kosher
Odor: popcorn; nutty, bread crust
Flavor: nutty
Used not only for popcorn type flavours, but also in roast nut flavours (hazelnut, peanut, almond), chocolate, bread and yeast type flavors. 2-Acetylpyrazine and 2-acetylthiazole both have aromas similar to the non-GRAS material 2-acetylpyrroline which is an important character impact compound in aromatic rice, bread crust and popcorn. Normal use levels in finished consumer product: 0.05-5 ppm. Council of Europe limits: foods (5 ppm); beverages (5 ppm).
Vigon International
Acetyl-2 Pyrazine
WEN International
Wujiang CIYUN Flavor & Fragrance
2-Acetyl Pyrazine ≥99.0%
Synonyms   Articles   Notes   Search   Top
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
Xi - Irritant
R 36/37/38 - Irritating to eyes, respiratory system, and skin.
S 02 - Keep out of the reach of children.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36 - Wear suitable protective clothing.
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
Skin irritation (Category 2), H315
Eye irritation (Category 2A), H319
Specific target organ toxicity - single exposure (Category 3), Respiratory system, H335
GHS Label elements, including precautionary statements
Signal word Warning
Hazard statement(s)
H315 - Causes skin irritation
H319 - Causes serious eye irritation
H335 - May cause respiratory irritation
Precautionary statement(s)
P261 - Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 - Wash skin thouroughly after handling.
P271 - Use only outdoors or in a well-ventilated area.
P280 - Wear protective gloves/protective clothing/eye protection/face protection.
P302 + P352 - IF ON SKIN: wash with plenty of soap and water.
P304 + P340 - IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312 - Call a POISON CENTER or doctor/physician if you feel unwell.
P332 + P313 - IF SKIN irritation occurs: Get medical advice/attention.
P337 + P313 - IF eye irritation persists: Get medical advice/attention.
P362 - Take off contaminated clothing and wash before reuse.
P403 + P233 - Store in a well-ventilated place. Keep container tightly closed.
P405 - Store locked up.
P501 - Dispose of contents/ container to an approved waste disposal plant.
Oral/Parenteral Toxicity:
gavage-rat LD50  [sex: M,F] > 3000 mg/kg
(Posternak et al., 1975)

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Synonyms   Articles   Notes   Search   Top
Safety in Use Information:
Category: flavor and fragrance agents
Recommendation for 2-acetyl pyrazine usage levels up to:
  0.0500 % in the fragrance concentrate.
Maximised Survey-derived Daily Intakes (MSDI-EU): 12.00 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 120.00 (μg/capita/day)
Structure Class: II
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 4
Click here to view publication 4
 average usual ppmaverage maximum ppm
baked goods: -5.00000
beverages(nonalcoholic): -5.00000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: -5.00000
fruit ices: -5.00000
gelatins / puddings: --
granulated sugar: --
gravies: --
hard candy: -5.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --
Synonyms   Articles   Notes   Search   Top
Safety References:
Flavor & Extract Manufacturers Association (FEMA) reference(s):
The FEMA GRAS assessment of pyrazine derivatives used as flavor ingredients.View pdf
European Food Safety Athority(efsa): Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...
European Food Safety Authority (EFSA) reference(s):
Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the Commission related to Flavouring Group Evaluation 17 (FGE.17): Pyrazine derivatives from chemical group 24 (Commission Regulation (EC) No 1565/2000 of 18 July 2000)
View page or View pdf
Flavouring Group Evaluation 50 (FGE.50): Consideration of pyrazine derivatives evaluated by JECFA (57th meeting) structurally related to pyrazine derivatives evaluated by EFSA in FGE.17 (2005) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf
Flavouring Group Evaluation 17, Revision 1 (FGE.17Rev1): Pyrazine derivatives from chemical group 24 - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) [1]
View page or View pdf
Scientific Opinion on Flavouring Group Evaluation 17, Revision 2 (FGE.17Rev2): Pyrazine derivatives from chemical group 24
View page or View pdf
Scientific Opinion on Flavouring Group Evaluation 50, Revision 1 (FGE.50Rev1): Consideration of pyrazine derivatives evaluated by JECFA (57th meeting) structurally related to pyrazine derivatives evaluated by EFSA in FGE.17Rev2 (2010)
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Safety and efficacy of pyrazine derivatives including saturated ones belonging to chemical group 24 when used as flavourings for all animal species
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EPI System: View
EPA Substance Registry Services (TSCA): 22047-25-2
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 30914
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 2
Chemidplus: 0022047252
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NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 22047-25-2
Pubchem (cid): 30914
Pubchem (sid): 134993897
Flavornet: 22047-25-2
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS): View
HMDB (The Human Metabolome Database): HMDB31861
Export Tariff Code: 2933.99.9700
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
Read: Under the conditions of intended use - New developments in the FEMA GRAS program and the safety assessment of flavor ingredients
Read: A GRAS assessment program for flavor ingredients
Read: Sensory testing for flavorings with modifying properties. Food Technology
Read: Criteria for the safety evaluation of flavoring substances
Read: A procedure for the safety evaluation of natural flavor complexes used as ingredients in food: essential oils
Read: FEMA Expert Panel: 30 Years of safety evaluation for the flavor industry
Read: Consumption ratio and food predominance of flavoring materials
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Potential Blenders and core components note
2-acetyl furanFL/FR
2-acetyl pyridineFL/FR
3-acetyl pyridineFL/FR
2-acetyl pyrroleFL/FR
2-acetyl thiazoleFL/FR
2-acetyl-3-ethyl pyrazineFL/FR
2-acetyl-3,5(or 6)-dimethyl pyrazineFL/FR
2-acetyl-5-methyl pyrazineFL
2-acetyl-6-methyl pyrazineFL
 acorn acetateFR
isoamyl benzoateFL/FR
isoamyl phenyl acetateFL/FR
 amyris wood oilFL/FR
para-anisyl alcoholFL/FR
 autumn carboxylateFR
siam benzoin resinoidFL/FR
 benzyl salicylateFL/FR
 butyl laurateFL/FR
2(4)-isobutyl-4(2),6-dimethyl dihydro-4H-1,3,5-dithiazineFL
 caramel furanoneFL
 caraway seed oleoresinFL/FR
 cassia bark oil chinaFL/FR
 cedrenyl acetateFR
 chocolate pyrazine AFL/FR
 chocolate pyrazine BFL
 cocoa hexenalFL/FR
 coffee furanoneFL/FR
black currant bud absoluteFL/FR
 diisoamyl thiomalateFL
2,3-dimethyl pyrazineFL/FR
 dimethyl sulfideFL/FR
2,4-dimethyl-5-vinyl thiazoleFL
 ethyl dimethyl pyrazineFL
 ethyl maltolFL/FR
2-ethyl pyrazineFL/FR
 ethyl vanillinFL/FR
 filbert pyrazineFL/FR
 furfuryl alcoholFL
 furfuryl octanoateFL
 geranyl crotonateFR
laevo-glutamic acidCS
 guaiacyl phenyl acetateFL/FR
 heliotropyl acetoneFL/FR
 immortelle absoluteFL/FR
 mastic gum resinFR
2-methoxy-3-methyl pyrazineFL/FR
2-methoxy-4-vinyl phenolFL/FR
2-methyl piperidineFL
2-methyl pyrazineFL/FR
5-methyl quinoxalineFL/FR
2-methyl thio-3,5 or 6-methyl pyrazineFL/FR
2-methyl undecanal (aldehyde C-12 mna)FL/FR
 nutty pyrazineFL/FR
 nutty quinoxalineFL/FR
 ocean propanalFL/FR
 peanut dithiazineFL
 phenyl acetic acidFL/FR
3-phenyl propyl alcoholFL/FR
 popcorn pyrimidineFL/FR
2-propionyl pyrroleFL
2-propionyl thiazoleFL
 shoyu furanoneFL/FR
 toffee furanoneFL/FR
 tonka bean absoluteFR
2,3,5-trimethyl pyrazineFL/FR
 vanilla bean absolute (vanilla planifolia)FL/FR
 veramoss (IFF)FR
 yeast thiazolineFL
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Potential Uses:
 bread bakedFR
 bread crisp bread 
 bread crust 
 bread rye bread 
 bread wheat bread 
 bread white bread 
 chocolate cocoa 
 corn chipFL
 graham crackerFR
 nut almond toastedFL
 nut cashewFL
 nut filbertFR
 nut hazelnutFR
 nut peanutFR
 nut pecanFL
 nut pistachioFL
 nut roasted 
 nut sesameFL
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Natural Occurrence in: note
 almond roasted almond
GRIN Trop Picture
GRIN Trop Picture
 potato chip
 sesame oil
GRIN Trop Picture
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 acetyl pyrazine
2-acetyl pyrazine
2-acetyl pyrazine FCC
 acetyl-2 pyrazine
2 acetylpyrazine
2-acetylpyrazine FCC
 ethanone, 1-(2-pyrazinyl)-
 ethanone, 1-pyrazinyl-
 ketone, methyl pyrazinyl
 methyl 2-pyrazinyl ketone
 methyl pyrazin-2-yl ketone
 methyl pyrazinyl ketone
 methyl-2-pyrazinyl ketone
 methylpyrazinyl ketone
 popcorn pyrazine
 pyrazine, 2- acetyl
 pyrazine, 2-acetyl-
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Perfumer & Flavorist: Flavor Bites: 2-Acetyl Pyrazine
US Patents: 3,952,024 - Furfurylthioacetone
PubMed: Identification of potent odorants formed during the preparation of extruded potato snacks.
US Patents: 3,931,166 - Certain 2,5-dimethyl-3-thiopyrazines
PubMed: Gas chromatography-olfactometry and chemical quantitative study of the aroma of six premium quality spanish aged red wines.
PubMed: How low pH can intensify beta-damascenone and dimethyl trisulfide production through beer aging.
PubMed: Main group bismuth(III), gallium(III) and diorganotin(IV) complexes derived from bis(2-acetylpyrazine)thiocarbonohydrazone: synthesis, crystal structures and biological evaluation.
PubMed: Synthesis, crystal structures, in vitro biological evaluation of zinc(II) and bismuth(III) complexes of 2-acetylpyrazine N(4)-phenylthiosemicarbazone.
PubMed: Cytotoxicity and structure-activity relationships of four alpha-N-heterocyclic thiosemicarbazone derivatives crystal structure of 2-acetylpyrazine thiosemicarbazone.
PubMed: (E)-2-Acetyl-pyrazine 4-nitro-phenyl-hydrazone.
PubMed: Effect of cysteine and cystine addition on sensory profile and potent odorants of extruded potato snacks.
PubMed: 2-Acetyl-pyrazine 4-methyl-thio-semi-carbazone.
PubMed: New Ag(I)-containing coordination polymers generated from multidentate Schiff-base ligands.
PubMed: Solvent-free reactions of C60 with active methylene compounds, either with or without carbon tetrabromide, in the presence of bases under high-speed vibration milling conditions.
PubMed: 2-benzoxazolyl and 2-benzimidazolyl hydrazones derived from 2-acetylpyridine: a novel class of antitumor agents.
PubMed: Studies on pyrazine derivatives--XXXIV. Synthesis and tuberculostatic activity of alpha-oxo ketene dithioacetals pyrazine derivatives.
PubMed: Measurement of interactions between polysaccharides and flavour compounds by exclusion size chromatography: advantages and limits.
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Picture of molecule
Soluble in:
 dipropylene glycol
 water, 6.652e+004 mg/L @ 25 °C (est)
 water, 6.65E+04 mg/L @ C (exp)
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