EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

methyl para-anisate
methyl p-anisate

Sponsors

Name:methyl 4-methoxybenzoate
CAS Number: 121-98-2Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:204-513-2
FDA UNII:2MFL7873W9
Nikkaji Web:J33.855I
Beilstein Number:2208571
MDL:MFCD00008437
CoE Number:248
XlogP3:2.30 (est)
Molecular Weight:166.17630000
Formula:C9 H10 O3
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:flavor and fragrance agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
JECFA Food Flavoring:884 methyl anisate
FLAVIS Number:09.713 (Old)
DG SANTE Food Flavourings:09.713 methyl 4-methoxybenzoate
FEMA Number:2679 methyl p-anisate
FDA:No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm: METHYL ANISATE
FDA Regulation:
FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION
Subpart F--Flavoring Agents and Related Substances
Sec. 172.515 Synthetic flavoring substances and adjuvants.
 
Physical Properties:
Appearance:white crystallin powder (est)
Assay: 98.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 48.00 to 50.00 °C. @ 760.00 mm Hg
Boiling Point: 244.00 to 245.00 °C. @ 760.00 mm Hg
Congealing Point:47.50 °C.
Acid Value: 1.00 max. KOH/g
Vapor Pressure:0.016000 mm/Hg @ 25.00 °C. (est)
Flash Point:> 230.00 °F. TCC ( > 110.00 °C. )
logP (o/w): 2.270
Soluble in:
 alcohol
 water, 643 mg/L 20 °C (exp)
Insoluble in:
 water
Similar Items:note
methyl 3-methoxybenzoate
methyl 2-methoxybenzoate
ethyl para-anisate
hexyl para-anisate
 
Organoleptic Properties:
Odor Type: anisic
Odor Strength:medium
herbal anise sweet
Odor Description:at 100.00 %. herbal anise sweet
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: perfuming agents
 
Suppliers:
Advanced Biotech
METHYL ANISATE NATURAL
Anhui Haibei
Methyl P-anisate natural
Odor: Herbal anise sweet
Bell Flavors & Fragrances
Natural Methyl Anisate
BOC Sciences
For experimental / research use only.
Methyl Anisate 99.0% (sum of isomers)
CG Herbals
Methyl Anisate
Odor: Sweet Herbaceous Delicately Floral
Inoue Perfumery
METHYL ANISATE
Kunshan Sainty
Methyl Anisate, Natural
Lluch Essence
METHYL PARA ANISATE
M&U International
NAT.METHYL ANISATE, Kosher
Matrix Scientific
For experimental / research use only.
Methyl 4-methoxybenzoate, 95+%
PCAS
Methyl Anisate, Kosher
Pearlchem Corporation
Natural Methyl Anisate
Penta International
METHYL ANISATE, Kosher
Penta International
METHYL ANISATE, NATURAL, Kosher
Sigma-Aldrich
Methyl p-anisate, ≥99%, FG
Odor: anise; chocolate; creamy; melon; fruity; sweet; vanilla; spicy; woody
Certified Food Grade Products
Sunaux International
nat.Methyl Anisate
Symphony Pharma
For experimental / research use only.
Methyl-4-methoxy-benzoate
Synerzine
Methyl p-anisate
TCI AMERICA
For experimental / research use only.
Methyl p-Anisate >99.0%(GC)
 
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
None - None found.
S 02 - Keep out of the reach of children.
S 24/25 - Avoid contact with skin and eyes.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Human Experience:
4 % solution: no irritation or sensitization.
Oral/Parenteral Toxicity:
oral-rat LD50 > 5000 mg/kg
(Levenstein, 1975k)

oral-rat LD50 > 5000 mg/kg
Food and Cosmetics Toxicology. Vol. 14, Pg. 481, 1976.

Dermal Toxicity:
skin-rabbit LD50 > 5000 mg/kg
Food and Cosmetics Toxicology. Vol. 14, Pg. 481, 1976.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: flavor and fragrance agents
Recommendation for methyl para-anisate usage levels up to:
  3.0000 % in the fragrance concentrate.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 0.97 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 0.01 (μg/capita/day)
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
 average usual ppmaverage maximum ppm
baked goods: -6.20000
beverages(nonalcoholic): -2.70000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: -3.00000
fruit ices: -3.00000
gelatins / puddings: --
granulated sugar: --
gravies: --
hard candy: -8.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --
 
Safety References:
European Food Safety Athority(efsa):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the Commission related to Flavouring Group Evaluation 20 (FGE.20): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical group 23
View page or View pdf

Flavouring Group Evaluation 52 (FGE.52): Consideration of hydroxy- and alkoxy-substituted benzyl derivatives evaluated by JECFA (57th meeting) structurally related to benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters evaluated by EFSA in FGE.20 (2005) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf

Flavouring Group Evaluation 54 (FGE.54)[1] - Consideration of benzyl derivatives evaluated by JECFA (57th meeting) structurally related to benzyl alcohols, benzaldehydes, a related acetal, benzoic acids and related esters evaluated by EFSA in FGE.20 (2005) - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food
View page or View pdf

Flavouring Group Evaluation 20, Revision 1 (FGE.20Rev1): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids and related esters from chemical group 23
View page or View pdf

Flavouring Group Evaluation 54, Revision 1 (FGE.54Rev1): Consideration of benzyl derivatives evaluated by JECFA (57th meeting) structurally related to benzyl alcohols, benzaldehydes, a related acetal, benzoic acids and related esters evaluated by EFSA in FGE.20Rev1 (2009)
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 20, Revision 2 (FGE.20Rev2): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical groups 23 and 30
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 20, Revision 3(FGE.20Rev3): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical groups 23 and 30
View page or View pdf

EPI System: View
Env. Mutagen Info. Center:Search
EPA Substance Registry Services (TSCA):121-98-2
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :8499
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
methyl 4-methoxybenzoate
Chemidplus:0000121982
RTECS:BZ4925000 for cas# 121-98-2
 
References:
 methyl 4-methoxybenzoate
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:121-98-2
Pubchem (cid):8499
Pubchem (sid):134973371
Pherobase:View
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS):View
CHEBI:View
CHEMBL:View
Metabolomics Database:Search
HMDB (The Human Metabolome Database):HMDB32639
FooDB:FDB010588
Export Tariff Code:2918.99.4700
Typical G.C.
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
RSC Learn Chemistry:View
 
Potential Blenders and core components note
For Odor
animal
para-
cresyl caprylate
FL/FR
anise
anise oleoresin
FL/FR
anise seed oil
FL/FR
star
anise seed oil china
FL/FR
anise seed oil colombia
FL/FR
star
anise seed oil terpeneless
FL/FR
sweet
fennel absolute
FL/FR
sweet
fennel oleoresin
FL/FR
sweet
fennel seed oil
FL/FR
anisic
ortho-
acetanisole
FL/FR
para-
acetanisole
FL/FR
amyl furoate
FL/FR
para-
anisaldehyde
FL/FR
ortho-
anisaldehyde
FL/FR
para-
anisyl phenyl acetate
FL/FR
para-
anisyl propanal
FR
dihydroanethol
FL/FR
ethyl para-anisate
FL/FR
ocimum basilicum herb oil
FL/FR
ocimum basilicum leaf oil america
FL/FR
sassafras acetate
FL/FR
balsamic
cinnamyl alcohol
FL/FR
geranyl benzoate
FL/FR
phenethyl cinnamate
FL/FR
prenyl benzoate
FL/FR
terpinyl benzoate
FR
berry
raspberry ketone methyl ether
FL/FR
chocolate
vanillyl ethyl ether
FL/FR
fatty
2,4-
decadien-1-ol
FL/FR
(E,E)-2,4-
decadien-1-ol
FL/FR
floral
acetophenone
FL/FR
para-
anisaldehyde / methyl anthranilate schiff's base
FR
para-
anisaldehyde dimethyl acetal
FR
anise indene
FR
para-
anisyl acetaldehyde
FL/FR
para-
anisyl nitrile
FR
anisyl propanal / methyl anthranilate schiff's base
FR
autumn carboxylate
FR
boronia absolute
FL/FR
champaca absolute
FR
cuminyl acetaldehyde
FL/FR
earthy indane
FR
para-
ethyl acetophenone
FL/FR
ethyl ortho-anisate
FL/FR
geranyl phenyl acetate
FL/FR
hawthorn acetate
FR
hawthorn carbinol
FL/FR
heliotropin
FL/FR
heliotropyl acetate
FL/FR
heliotropyl acetone
FL/FR
para-
methyl acetophenone
FL/FR
orris rhizome resinoid (iris pallida)
FL/FR
phenethyl salicylate
FL/FR
(R)-2-
phenyl propyl alcohol
FL/FR
propiophenone
FL/FR
iso
propyl anthranilate
FL/FR
tuberose absolute (from concrete)
FL/FR
tuberose absolute (from pommade)
FL/FR
tuberose acetate
FR
wallflower absolute
FR
fruity
para-
anisyl methyl ketone
FL/FR
benzyl methyl ether
FL/FR
berry hexanoate
FR
diethyl sebacate
FL/FR
diethyl succinate
FL/FR
(E,E)-
ethyl sorbate
FL/FR
grapefruit acetal
FR
green
3,6-
nonadien-1-yl acetate
FL/FR
(E,Z)-3,6-
nonadien-1-yl acetate
FL/FR
tiglaldehyde
FL/FR
herbal
acorn acetate
FR
floral nitrile
FR
tricyclodecenyl isobutyrate
FR
licorice
(E)-
anethol
FL/FR
melon
melon heptenal
FL/FR
minty
bitter
fennel seed oil lithuania
CS
naphthyl
para-
methyl anisole
FL/FR
beta-
naphthyl methyl ether
FL/FR
phenolic
anisole
FL/FR
powdery
para-
anisyl alcohol
FL/FR
smoky
propyl paraben
CS
spicy
croton eluteria bark oil
FL/FR
sweet
vanilla oleoresin bali
FL/FR
terpenic
angelica seed oil
FL/FR
vanilla
ethyl vanillin isobutyrate
FL/FR
vanillin
FL/FR
vanillin propylene glycol acetal
FL/FR
woody
cyperus root oil (cyperus rotundus)
FR
patchouli ethanone
FR
For Flavor
No flavor group found for these
amyl furoate
FL/FR
para-
anisyl acetaldehyde
FL/FR
(E,E)-2,4-
decadien-1-ol
FL/FR
para-
ethyl acetophenone
FL/FR
4-
ethyl anisole
FL
ethyl ortho-anisate
FL/FR
geranyl benzoate
FL/FR
(R)-2-
phenyl propyl alcohol
FL/FR
prenyl benzoate
FL/FR
iso
propyl anthranilate
FL/FR
4'-
hydroxyacetophenone
FL
amber
amber
angelica seed oil
FL/FR
animal
para-
cresyl caprylate
FL/FR
anise
(E)-
anethol
FL/FR
anise oleoresin
FL/FR
anise seed oil
FL/FR
star
anise seed oil china
FL/FR
anise seed oil colombia
FL/FR
star
anise seed oil terpeneless
FL/FR
ethyl para-anisate
FL/FR
sweet
fennel absolute
FL/FR
sweet
fennel oleoresin
FL/FR
sweet
fennel seed oil
FL/FR
anisic
para-
acetanisole
FL/FR
ortho-
anisaldehyde
FL/FR
para-
anisyl phenyl acetate
FL/FR
aromatic
anisole
FL/FR
balsamic
phenethyl cinnamate
FL/FR
berry
heliotropyl acetone
FL/FR
raspberry ketone methyl ether
FL/FR
cherry
heliotropin
FL/FR
cocoa
cocoa distillates
FL
creamy
para-
anisaldehyde
FL/FR
para-
methyl acetophenone
FL/FR
fatty
2,4-
decadien-1-ol
FL/FR
floral
geranyl phenyl acetate
FL/FR
heliotropyl acetate
FL/FR
orris rhizome resinoid (iris pallida)
FL/FR
tuberose absolute (from concrete)
FL/FR
tuberose absolute (from pommade)
FL/FR
fruity
para-
anisyl alcohol
FL/FR
benzyl methyl ether
FL/FR
boronia absolute
FL/FR
diethyl sebacate
FL/FR
diethyl succinate
FL/FR
(E,E)-
ethyl sorbate
FL/FR
propiophenone
FL/FR
tiglaldehyde
FL/FR
green
cinnamyl alcohol
FL/FR
cuminyl acetaldehyde
FL/FR
melon heptenal
FL/FR
(E,Z)-3,6-
nonadien-1-yl acetate
FL/FR
3,6-
nonadien-1-yl acetate
FL/FR
herbal
dihydroanethol
FL/FR
ocimum basilicum herb oil
FL/FR
ocimum basilicum leaf oil america
FL/FR
licorice
2-
butyl-3-methyl pyrazine
FL
medicinal,
phenethyl salicylate
FL/FR
naphthyl
para-
methyl anisole
FL/FR
beta-
naphthyl methyl ether
FL/FR
powdery
ortho-
acetanisole
FL/FR
acetophenone
FL/FR
powdery ketone
FL
rummy
vanillyl ethyl ether
FL/FR
spicy
para-
anisyl methyl ketone
FL/FR
croton eluteria bark oil
FL/FR
hawthorn carbinol
FL/FR
4-
methyl biphenyl
FL
sulfurous
O-
ethyl S-1-methoxyhexan-3-yl carbonothioate
FL
sweet
vanilla oleoresin bali
FL/FR
tarragon
sassafras acetate
FL/FR
vanilla
ethyl vanillin isobutyrate
FL/FR
vanillin
FL/FR
vanillin propylene glycol acetal
FL/FR
 
Potential Uses:
FLchervil
FRfennel
FRfern
FRfungus
FRhawthorn
FRhay new mown hay
FRheliotrope
FRlinden flower
FRmagnolia
 melon watermelon muskmelon cantaloupe
FRmimosa
FRpumpkin pie
FRreseda
FRspruce
FRsweet pea
 
Occurrence (nature, food, other):note
 anise star anise fruit
Search Trop Picture
 anise star anise seed
Search Trop Picture
 cassie absolute @ 0.31%
Data GC Search Trop Picture
 cocoa
Search Trop Picture
 feijoa fruit
Search Trop Picture
 guava pineapple guava
Search Trop Picture
 mushroom
Search PMC Picture
 tea black tea
Search Trop Picture
 vanilla
Search Picture
 wine white wine
Search Picture
 ylang ylang oil @ 0.06%
Data GC Search Trop Picture
 
Synonyms:
p-anisic acid methyl ester
para-anisic acid methyl ester
p-anisic acid, methyl ester
 benzoic acid, 4-methoxy-, methyl ester
 menthyll anisate
4-methoxybenzoic acid methyl ester
para-methoxybenzoic acid methyl ester
 methyl 4-methoxybenzoate
 methyl anisate
nat.methyl anisate
 methyl anisate natural
 methyl p-anisate
 methyl p-methoxy benzoate
 methyl p-methoxybenzoate
 methyl para-methoxybenzoate
 methyl-4-methoxybenzoate
 

Articles:

PubMed:(2-Nitroethyl)benzene: a major flower scent from the Japanese loquat Eriobotrya japonica [Rosales: Rosaceae].
PubMed:Validating a breath collection and analysis system for the new tuberculosis breath test.
PubMed:Diagnostic potential of the pulsed discharged helium ionization detector (PDHID) for pathogenic Mycobacterial volatile biomarkers.
PubMed:Assessment of potential causes of falsely positive Mycobacterium tuberculosis breath test.
PubMed:Diagnosis of tuberculosis by trained African giant pouched rats and confounding impact of pathogens and microflora of the respiratory tract.
PubMed:Honeybees Apis mellifera can detect the scent of Mycobacterium tuberculosis.
PubMed:Synthesis of [(125)I]iodoDPA-713: a new probe for imaging inflammation.
PubMed:The scent of Mycobacterium tuberculosis.
PubMed:The anise-like odor of Clitocybe odora, Lentinellus cochleatus and Agaricus essettei.
PubMed:Synthesis of a C(29)-C(51) subunit of spongistatin 1 (Altohyrtin A) starting from (R)-3-benzyloxy-2-methylpropan-1-ol.
PubMed:High-performance liquid chromatographic determinaton of pentaerythritol in plasma.
 
Notes:
Gives good body. Flavouring ingredient
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