EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

4-methoxysalicylaldehyde
2-hydroxy-4-methoxybenzaldehyde

Supplier Sponsors

Name:2-hydroxy-4-methoxybenzaldehyde
CAS Number: 673-22-3Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:211-604-0
FDA UNII:2N395P88LW
Nikkaji Web:J155.609F
Beilstein Number:1072443
MDL:MFCD00003327
XlogP3:1.50 (est)
Molecular Weight:152.14936000
Formula:C8 H8 O3
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:flavoring agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
FEMA Number:4435 2-hydroxy-4-methoxybenzaldehyde
FDA:No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm: 2-HYDROXY-4-METHOXYBENZALDEHYDE
 
Physical Properties:
Appearance:colorless to pale yellow clear solid (est)
Assay: 97.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 41.00 to 43.00 °C. @ 760.00 mm Hg
Boiling Point: 269.00 to 270.00 °C. @ 760.00 mm Hg
Boiling Point: 124.00 °C. @ 12.00 mm Hg
Vapor Pressure:0.004000 mm/Hg @ 25.00 °C. (est)
Flash Point: 235.00 °F. TCC ( 112.78 °C. )
logP (o/w): 2.057 (est)
Soluble in:
 alcohol
 water, 4651 mg/L @ 25 °C (est)
Insoluble in:
 water
 
Organoleptic Properties:
Odor Type: vanilla
Odor Strength:medium
vanilla
Odor Description:at 100.00 %. vanillin like
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Axsyn
For experimental / research use only.
Benzaldehyde,2-hydroxy-4-methoxy-
BOC Sciences
For experimental / research use only.
4-Methoxysalicylaldehyde >98%
EMD Millipore
For experimental / research use only.
2-Hydroxy-4-methoxybenzaldehyde
Parchem
4-methoxysalicylaldehyde
Penta International
2-HYDROXY-4-METHOXYBENZALDEHYDE
Santa Cruz Biotechnology
For experimental / research use only.
4-Hydroxy-4-methoxybenzaldehyde
Sigma-Aldrich: Aldrich
For experimental / research use only.
2-Hydroxy-4-methoxybenzaldehyde 98%
TCI AMERICA
For experimental / research use only.
2-Hydroxy-4-methoxybenzaldehyde >97.0%(T)
 
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
Xi - Irritant
R 36/37/38 - Irritating to eyes, respiratory system, and skin.
S 02 - Keep out of the reach of children.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36 - Wear suitable protective clothing.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: flavoring agents
Recommendation for 4-methoxysalicylaldehyde usage levels up to:
 not for fragrance use.
 
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 24
 average usual ppmaverage maximum ppm
baked goods: 10.00000100.00000
beverages(nonalcoholic): 5.0000050.00000
beverages(alcoholic): 20.0000050.00000
breakfast cereal: 10.00000100.00000
cheese: --
chewing gum: 20.00000100.00000
condiments / relishes: --
confectionery froastings: 10.0000050.00000
egg products: --
fats / oils: --
fish products: --
frozen dairy: 10.0000050.00000
fruit ices: --
gelatins / puddings: 10.0000050.00000
granulated sugar: --
gravies: --
hard candy: 20.00000100.00000
imitation dairy: --
instant coffee / tea: 10.0000025.00000
jams / jellies: --
meat products: --
milk products: 10.0000050.00000
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: 100.000001000.00000
snack foods: --
soft candy: 10.0000050.00000
soups: --
sugar substitutes: --
sweet sauces: 10.0000050.00000
 
Safety References:
EPI System: View
Cancer Citations:Search
Env. Mutagen Info. Center:Search
EPA Substance Registry Services (TSCA):673-22-3
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :69600
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
2-hydroxy-4-methoxybenzaldehyde
Chemidplus:0000673223
RTECS:BZ2810000 for cas# 673-22-3
 
References:
 2-hydroxy-4-methoxybenzaldehyde
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):69600
Pubchem (sid):135028287
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS):View
CHEBI:View
CHEMBL:View
HMDB (The Human Metabolome Database):Search
FooDB:FDB005824
Export Tariff Code:2912.49.2600
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
RSC Learn Chemistry:View
 
Potential Blenders and core components note
For Odor
anisic
para-
acetanisole
FL/FR
ortho-
anisaldehyde
FL/FR
para-
anisaldehyde
FL/FR
methyl para-anisate
FL/FR
balsamic
siam
benzoin absolute
FL/FR
benzoin absolute replacer
FL/FR
sumatra
benzoin gum
FL/FR
sumatra
benzoin resin
FL/FR
siam
benzoin resin
FL/FR
sumatra
benzoin resinoid
FL/FR
siam
benzoin resinoid
FL/FR
1-
benzoyl acetone
FL/FR
peru balsam absolute
FL/FR
peru balsam oil
FL/FR
peru balsam resinoid
FL/FR
berry
raspberry ketone methyl ether
FL/FR
caramellic
levulinic acid
FL/FR
chocolate
vanillyl ethyl ether
FL/FR
coconut
alpha-
angelica lactone
FL/FR
coumarinic
coumane
FL/FR
creamy
butyl lactate
FL/FR
para-
vanillic acid
FL/FR
para-
vanillyl alcohol
FL/FR
veratraldehyde
FL/FR
floral
acetophenone
FL/FR
para-
cresyl laurate
FL/FR
heliotropin
FL/FR
para-
methyl acetophenone
FL/FR
fruity
para-
anisyl propionate
FL/FR
ethyl methyl-para-tolyl glycidate
FL/FR
guaiacyl propionate
FL/FR
tolualdehydes (mixed o,m,p)
FL/FR
musk
omega-
pentadecalactone
FL/FR
naphthyl
2,4-
dimethyl benzaldehyde
FL/FR
nutty
nutty cyclohexenone
FL/FR
2,3,5,6-
tetramethyl pyrazine
FL/FR
phenolic
ortho-
guaiacol
FL/FR
powdery
para-
anisyl acetate
FL/FR
smoky
alpha-
ethoxy-ortho-cresol
FL/FR
spicy
para-
anisyl formate
FL/FR
4-
ethyl guaiacol
FL/FR
para-
methoxycinnamaldehyde
FL/FR
(E)-para-
methoxycinnamaldehyde
FL/FR
4-
methyl guaiacol
FL/FR
spicy acetoacetate
FL/FR
zingerone
FL/FR
sweet
vanilla bean absolute (vanilla spp.)
FL/FR
vanilla oleoresin bali
FL/FR
vanilla oleoresin bourbon
FL/FR
vanilla resinoid
FL/FR
vanilla tahitensis fruit extract
FL/FR
tonka
mint lactone
FL/FR
octahydrocoumarin
FL/FR
tropical
curcuma amada roxb. rhizome oil CO2 extract
FL/FR
vanilla
acetovanillone
FL/FR
ortho-
dimethyl hydroquinone
FL/FR
ethyl vanillin
FL/FR
ethyl vanillin isobutyrate
FL/FR
ethyl vanillin propylene glycol acetal
FL/FR
heliotropyl alcohol
FL/FR
methyl vanillate
FL/FR
propenyl guaethol
FL/FR
vanilla aromatica fruit extract
FL/FR
vanilla bean absolute (vanilla planifolia)
FL/FR
vanilla bean absolute CO2 extract (vanilla planifolia)
FL/FR
vanilla bean oil (vanilla tahitensis)
FL/FR
vanilla bean oil CO2 extract
FL/FR
vanilla extract
FL/FR
vanilla planifolia fruit extract
FL/FR
vanilla planifolia fruit water
FL/FR
vanillin
FL/FR
vanillin 2,3-butylene glycol acetal
FL/FR
vanillin propylene glycol acetal
FL/FR
vanillyl acetate
FL/FR
vanillyl isobutyrate
FL/FR
vanillylidene acetone
FL/FR
woody
4-
hydroxybenzaldehyde
FL/FR
For Flavor
No flavor group found for these
para-
anisyl propionate
FL/FR
1-
benzoyl acetone
FL/FR
coumane
FL/FR
ortho-
dimethyl hydroquinone
FL/FR
alpha-
ethoxy-ortho-cresol
FL/FR
3-(2-
furyl) acrolein
FL
glucoethyl vanillin
FL
glucovanillin
FL
guaiacyl propionate
FL/FR
heliotropyl alcohol
FL/FR
(E)-para-
methoxycinnamaldehyde
FL/FR
methyl para-anisate
FL/FR
methyl vanillate
FL/FR
vanilmandelic acid
FL
acidic
acidic
levulinic acid
FL/FR
anisic
para-
acetanisole
FL/FR
ortho-
anisaldehyde
FL/FR
balsamic
benzoin absolute replacer
FL/FR
sumatra
benzoin gum
FL/FR
sumatra
benzoin resin
FL/FR
siam
benzoin resin
FL/FR
siam
benzoin resinoid
FL/FR
sumatra
benzoin resinoid
FL/FR
peru balsam
FL
peru balsam absolute
FL/FR
peru balsam oil
FL/FR
peru balsam resinoid
FL/FR
vanillylidene acetone
FL/FR
berry
raspberry ketone methyl ether
FL/FR
bready
2-
propionyl thiazole
FL
cherry
heliotropin
FL/FR
para-
methoxycinnamaldehyde
FL/FR
coconut
6-
methyl coumarin
FL
octahydrocoumarin
FL/FR
creamy
alpha-
angelica lactone
FL/FR
para-
anisaldehyde
FL/FR
divanillin
FL
4-
hydroxybenzaldehyde
FL/FR
para-
methyl acetophenone
FL/FR
mint lactone
FL/FR
para-
vanillic acid
FL/FR
para-
vanillyl alcohol
FL/FR
veratraldehyde
FL/FR
dairy
butyl lactate
FL/FR
fruity
para-
anisyl acetate
FL/FR
ethyl methyl-para-tolyl glycidate
FL/FR
tolualdehydes (mixed o,m,p)
FL/FR
meaty
4-
allyl-2,6-dimethoxyphenol
FL
naphthyl
2,4-
dimethyl benzaldehyde
FL/FR
nutty
furfural acetone
FL
nutty cyclohexenone
FL/FR
2,3,5,6-
tetramethyl pyrazine
FL/FR
powdery
acetophenone
FL/FR
powdery ketone
FL
rummy
vanillyl ethyl ether
FL/FR
spicy
para-
anisyl formate
FL/FR
siam
benzoin absolute
FL/FR
spicy acetoacetate
FL/FR
zingerone
FL/FR
sweet
vanilla bean absolute (vanilla spp.)
FL/FR
vanilla oleoresin bali
FL/FR
vanilla oleoresin bourbon
FL/FR
vanilla resinoid
FL/FR
vanilla tahitensis fruit extract
FL/FR
tropical
curcuma amada roxb. rhizome oil CO2 extract
FL/FR
vanilla
acetovanillone
FL/FR
ethyl vanillin
FL/FR
ethyl vanillin isobutyrate
FL/FR
ethyl vanillin propylene glycol acetal
FL/FR
4-
methyl guaiacol
FL/FR
omega-
pentadecalactone
FL/FR
propenyl guaethol
FL/FR
vanilla aromatica fruit extract
FL/FR
vanilla bean absolute (vanilla planifolia)
FL/FR
vanilla bean absolute CO2 extract (vanilla planifolia)
FL/FR
vanilla bean oil (vanilla tahitensis)
FL/FR
vanilla bean oil CO2 extract
FL/FR
vanilla extract
FL/FR
vanilla planifolia fruit extract
FL/FR
vanilla planifolia fruit water
FL/FR
vanillin
FL/FR
vanillin 2,3-butylene glycol acetal
FL/FR
vanillin propylene glycol acetal
FL/FR
vanillyl acetate
FL/FR
vanillyl isobutyrate
FL/FR
waxy
para-
cresyl laurate
FL/FR
woody
4-
ethyl guaiacol
FL/FR
ortho-
guaiacol
FL/FR
 
Potential Uses:
 antioxidants
FRheliotrope
FLvanilla
 
Occurrence (nature, food, other):note
 decalepis hamiltonii
Search Trop Picture
 periploca sepium
Search Trop Picture
 walnut black walnut oil
Search Trop Picture
 
Synonyms:
p-anisaldehyde, 2-hydroxy-
 benzaldehyde, 2-hydroxy-4-methoxy-
 benzaldehyde,2-hydroxy-4-methoxy-
2-formyl-5-methoxyphenol
2-hydroxy-4-methoxybenzaldehyde
4-hydroxy-4-methoxybenzaldehyde
2-hydroxy-p-anisaldehyde
o-hydroxy-p-methoxybenzaldehyde
2-hydroxy-para-anisaldehyde
ortho-hydroxy-para-methoxybenzaldehyde
 salicylaldehyde, 4-methoxy-
 

Articles:

PubMed:Chemical composition of root aroma of Decalepis arayalpathra (J. Joseph and V. Chandras.) Venter, an endemic and endangered ethnomedicinal plant from Western Ghats, India.
PubMed:7-Substituted-sulfocoumarins are isoform-selective, potent carbonic anhydrase II inhibitors.
PubMed:Flavoring extracts of Hemidesmus indicus roots and Vanilla planifolia pods exhibit in vitro acetylcholinesterase inhibitory activities.
PubMed:Shikimate pathway modulates the elicitor-stimulated accumulation of fragrant 2-hydroxy-4-methoxybenzaldehyde in Hemidesmus indicus roots.
PubMed:Essential oils composition of Periploca laevigata Aiton subsp. angustifolia (Labill.) Markgraf (Apocynaceae-Periplocoideae).
PubMed:Food protective effects of Periploca sepium oil and its active component against stored food mites.
PubMed:Modification of gold nanoparticle loaded on activated carbon with bis(4-methoxysalicylaldehyde)-1,2-phenylenediamine as new sorbent for enrichment of some metal ions.
PubMed:Spectral studies of copper(II) complexes of tridentate acylhydrazone ligands with heterocyclic compounds as coligands: X-ray crystal structure of one acylhydrazone copper(II) complex.
PubMed:Synthesis and characterization of Mo(VI) complexes derived from ONO donor acylhydrazones.
PubMed:Inhibition of Helicobacter pylori growth and its cytotoxicity by 2-hydroxy 4-methoxy benzaldehyde of Decalepis hamiltonii (Wight & Arn); a new functional attribute.
PubMed:Antimicrobial and antioxidant activities of the root bark essential oil of Periploca sepium and its main component 2-hydroxy-4-methoxybenzaldehyde.
PubMed:A manganese single-chain magnet exhibits a large magnetic coercivity.
PubMed:Two thiosemicarbazones derived from salicylaldehyde: very specific hydrogen-bonding interactions of the N-H...S=C type.
PubMed:Synthesis, spectral characterization and crystal structure of N-2-hydroxy-4-methoxybenzaldehyde-N'-4-nitrobenzoyl hydrazone and its square planar Cu(II) complex.
PubMed:Repellent from traditional Chinese medicine, Periploca sepium Bunge.
PubMed:Phenylalanine ammonia-lyase-mediated biosynthesis of 2-hydroxy-4-methoxybenzaldehyde in roots of Hemidesmus indicus.
PubMed:Antioxidant property of Decalepis hamiltonii Wight & Arn.
PubMed:Isolation of antioxidant compounds from the methanolic extract of the roots of Decalepis hamiltonii (Wight and Arn.).
PubMed:Production of 2-hydroxy-4-methoxybenzaldehyde in roots of tissue culture raised and acclimatized plants of Decalepis hamiltonii Wight & Arn., an endangered shrub endemic to Southern India and evaluation of its performance vis-a-vis plants from natural habitat.
PubMed:2-hydroxy-4-isopropylbenzaldehyde, a potent partial tyrosinase inhibitor.
PubMed:Determination of 2-hydroxy-4-methoxybenzaldehyde in roots of Decalepis hamiltonii (Wight & Arn.) and Hemidesmus indicus R.Br.
PubMed:Essential oil constituents and in vitro antimicrobial activity of Decalepis hamiltonii roots against foodborne pathogens.
PubMed:2-Hydroxy-4-methoxybenzaldehyde: a potent tyrosinase inhibitor from African medicinal plants.
 
Notes:
From African medicinal plants: Mondia whitei (Asclepiadaceae), Rhus vulagaris (Anacardiaceae), Sclerocarya caffra (Anacardiaceae). from african medicinal plants: mondia whitei (asclepiadaceae), rhus vulagaris (anacardiaceae), sclerocarya caffra (anacardiaceae).
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