EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

zingerone
vanillyl acetone

Sponsors

Name:4-(4-hydroxy-3-methoxyphenyl)butan-2-one
CAS Number: 122-48-5Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:204-548-3
FDA UNII:4MMW850892
Nikkaji Web:J5.356B
Beilstein Number:2051099
MDL:MFCD00048232
CoE Number:139
XlogP3:0.80 (est)
Molecular Weight:194.23018000
Formula:C11 H14 O3
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:flavor and fragrance agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
JECFA Food Flavoring:730 zingerone
FLAVIS Number:07.005 (Old)
DG SANTE Food Flavourings:07.005 vanillyl acetone
FEMA Number:3124 zingerone
FDA:No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm: ZINGERONE
FDA Regulation:
FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION
Subpart F--Flavoring Agents and Related Substances
Sec. 172.515 Synthetic flavoring substances and adjuvants.
 
Physical Properties:
Appearance:yellow to yellow brown crystals (est)
Assay: 96.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 39.00 to 42.00 °C. @ 760.00 mm Hg
Boiling Point: 141.00 to 0.50 °C. @ 0.00 mm Hg
Boiling Point: 290.00 °C. @ 760.00 mm Hg
Vapor Pressure:0.000143 mm/Hg @ 25.00 °C. (est)
Flash Point: 255.00 °F. TCC ( 123.70 °C. ) (est)
logP (o/w): 1.168 (est)
Soluble in:
 ethyl alcohol, 1:1 in 50% alcohol
 water, 3571 mg/L @ 25 °C (est)
Stability:
 no special storage precautions necessary
 non-discoloring
 stable in most media
 
Organoleptic Properties:
Odor Type: spicy
Odor Strength:medium
Substantivity:337 hour(s) at 10.00 % in dipropylene glycol
sweet spicy phenolic ginger vanilla woody
Odor Description:at 100.00 %. sweet spicy phenolic ginger vanilla woody
Luebke, William tgsc, (1986)
Odor sample from: Givaudan Corporation
spicy phenolic balsamic creamy vanilla
Odor Description:Spicy, phenolic and balsamic with a creamy vanilla-like nuance
Mosciano, Gerard P&F 20, No. 1, 31, (1995)
Flavor Type: spicy
ginger spicy
Taste Description: at 80.00 ppm. Spicy with a biting, lingering heat
Mosciano, Gerard P&F 20, No. 1, 31, (1995)
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: perfuming agents
 
Suppliers:
Advanced Biotech
ZINGERONE NATURAL
98% min.
Odor: Spicy vanilla
Apiscent Labs
ZINGERONE (VANILYL ACETONE)
Odor: Spicy, sweet, reminiscent of ginger
Apple Flavor & Fragrance
Zingerone
Aroma Aromatics & Flavours
Zingerone
Flavor: Strong pungent
In Perfumery it finds use as a sweetener of warm, slightly spicy-tobacco like effect which can be modified into 'leather' notes 'tobacco' notes or even heavy floral 'Jasmin' notes. It has often very attractive influence upon castoreum and labdanum and it blends very well with Ylang and Gardenia bases. It is an excellent flavour material, not only for Vanilla imitation where again it gives interesting effect with castoreum, but it is frequently used in many types of fruit flavours, root beer, spice blends, ginger and in tobacco flavourings. The normal concentration in finished products is about 5 to 15 ppm.
Aromiens International
Zingerone Natural
Beijing Lys Chemicals
Zingerone
Bell Flavors & Fragrances
Natural Zingerone
Berjé
Zingerone
Happening at Berje
BOC Sciences
For experimental / research use only.
Zingerone
CG Herbals
Zingerone
Odor: Spicy, pungent, characteristic of ginger
Use: Zingerone imparts spicy notes to all types of perfumes compositions. It is also used in artificial spice oils.
Ernesto Ventós
ZINGERONE
Odor: CREAMY, BERRY LIKE
Indukern F&F
ZINGERONE
Odor: SWEET, SPICY, PHENOLIC, WOODY
Kun Shan P&A
Zingerone
Kunshan Sainty
Zingerone, Kosher
Kunshan Sainty
Zingerone, Natural
M&U International
NAT.ZINGERONE, Kosher
M&U International
ZINGERONE, Kosher
Moellhausen
ZINGERONE
Odor: sweet aromatic, phenolic, balsamic, with creamy vanilla-like nuance; spicy, pungent, characteristic of ginger
Flavor: sweet aromatic, vanilla-like and slightly spicy
Pearlchem Corporation
Natural Zingerone
Penta International
ZINGERONE CONG. SOLID, Kosher
Penta International
ZINGERONE CRYST. POWDER, Kosher
Penta International
ZINGERONE, NATURAL, Kosher
Reincke & Fichtner
Zingerone natural
Reincke & Fichtner
Zingerone
Santa Cruz Biotechnology
For experimental / research use only.
Vanillylacetone
Sigma-Aldrich
Vanillylacetone, ≥96%, FG
Odor: clove; creamy; spicy; sweet; animal
Certified Food Grade Products
Sunaux International
nat.Zingerone
Sunaux International
Zingerone
Synerzine
Zingerone
TCI AMERICA
For experimental / research use only.
4-(4-Hydroxy-3-methoxyphenyl)-2-butanone >98.0%(GC)
Treatt
Zingerone
Odor: sweet-spicy, weak balsamic-vanilla
Vigon International
Vanillyl Acetone (Zingerone)
WEN International
ZINGERONE
Synthetic
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 2580 mg/kg
(Moreno, 1977ae)

oral-rat LD50 2580 mg/kg
Food and Chemical Toxicology. Vol. 20, Pg. 851, 1982.

Dermal Toxicity:
skin-rabbit LD50 > 5000 mg/kg
Food and Chemical Toxicology. Vol. 20, Pg. 851, 1982.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: flavor and fragrance agents
Recommendation for zingerone usage levels up to:
  2.0000 % in the fragrance concentrate.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 34.00 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 83.00 (μg/capita/day)
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
 average usual ppmaverage maximum ppm
baked goods: -11.00000
beverages(nonalcoholic): -6.90000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: -15.00000
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: -7.80000
fruit ices: -7.80000
gelatins / puddings: --
granulated sugar: --
gravies: --
hard candy: -11.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --
 
Safety References:
European Food Safety Athority(efsa):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Flavouring Group Evaluation 22 (FGE.22): Ring-substituted phenolic substances from chemical groups 21 and 25 (Commission Regulation (EC) No 1565/2000 of 18 July 2000)
View page or View pdf

Flavouring Group Evaluation 58 (FGE.58) Consideration of phenol derivatives evaluated by JECFA (55th meeting) structurally related to ring substituted phenolic substances evaluated by EFSA in FGE.22 (2006) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf

Flavouring Group Evaluation 60 (FGE.60): Consideration of eugenol and related hydroxyallylbenzene derivatives evaluated by JECFA (65th meeting) structurally related to ring- substituted phenolic substances evaluated by EFSA in FGE.22 (2006)
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 22, Revision 1 (FGE.22Rev1): Ring-substituted phenolic substances from chemical groups 21 and 25
View page or View pdf

Safety and efficacy of aromatic ketones, secondary alcohols and related esters belonging to chemical group 21 when used as flavourings for all animal species
View page or View pdf

EPI System: View
NLM Hazardous Substances Data Bank:Search
Chemical Carcinogenesis Research Information System:Search
Cancer Citations:Search
Toxicology Citations:Search
Env. Mutagen Info. Center:Search
EPA Substance Registry Services (TSCA):122-48-5
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :31211
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
4-(4-hydroxy-3-methoxyphenyl)butan-2-one
Chemidplus:0000122485
RTECS:EL8900000 for cas# 122-48-5
 
References:
 4-(4-hydroxy-3-methoxyphenyl)butan-2-one
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:122-48-5
Pubchem (cid):31211
Pubchem (sid):134973883
Pherobase:View
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS):View
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C17497
HMDB (The Human Metabolome Database):HMDB32590
FooDB:FDB010527
YMDB (Yeast Metabolome Database):YMDB01809
Haz-Map:View
Typical G.C.
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
RSC Learn Chemistry:View
Formulations/Preparations:
commercial product contains a minimum of 93% zingerone.
 
Potential Blenders and core components note
For Odor
anise
sweet
fennel seed oil
FL/FR
balsamic
amyris wood oil
FL/FR
siam
benzoin absolute
FL/FR
guaiacyl phenyl acetate
FL/FR
peru balsam absolute
FL/FR
peru balsam resinoid
FL/FR
3-
phenyl propyl alcohol
FL/FR
chocolate
iso
amyl phenyl acetate
FL/FR
citrus
bergamot oil
FL/FR
bergamot oil bergaptene reduced italy
FL/FR
bergamot oil turkey
FL/FR
dihydromyrcenol
FL/FR
methyl heptenone
FL/FR
sweet
orange peel oil c.p. brazil
FL/FR
creamy
veratraldehyde
FL/FR
floral
benzyl isobutyrate
FL/FR
bois de rose oil brazil
FL/FR
citronellol
FL/FR
coriander seed oil
FL/FR
cyclohexyl ethyl alcohol
FL/FR
floral pyranol
FR
geraniol
FL/FR
geranyl acetate
FL/FR
jasmin absolute (from pommade)
FL/FR
jasmin absolute egypt (from concrete)
FL/FR
jasmin absolute italy (from concrete)
FL/FR
leerall
FR
linalool
FL/FR
laevo-
linalool
FL/FR
linalool oxide
FL/FR
methyl dihydrojasmonate
FL/FR
nerol
FL/FR
neryl acetate
FL/FR
ocean propanal
FL/FR
petitgrain oil paraguay
FL/FR
phenethyl acetate
FL/FR
fruity
ethyl heptanoate
FL/FR
green acetate
FR
methyl (Z)-5-octenoate
FL/FR
gamma-
undecalactone (aldehyde C-14 (so-called))
FL/FR
green
(Z)-3-
hexen-1-ol
FL/FR
(Z)-3-
hexen-1-yl acetate
FL/FR
hexyl tiglate
FL/FR
2,4-
ivy carbaldehyde
FL/FR
melon nonenoate
FL/FR
styralyl acetate
FL/FR
herbal
carum carvi fruit oil
FL/FR
clary sage oil france
FL/FR
lavender absolute bulgaria
FL/FR
linalyl acetate
FL/FR
licorice
(E)-
anethol
FL/FR
mossy
veramoss (IFF)
FR
phenolic
para-alpha-
dimethyl styrene
FL/FR
powdery
para-
anisyl alcohol
FL/FR
spicy
allspice berry oil
FL/FR
allspice oil
FL/FR
alpinia galanga oil
FL/FR
alpinia galanga rhizome extract
FL/FR
alpinia galanga rhizome oil CO2 extract
FL/FR
atractylis root oil
FR
benzyl isoeugenol
FL/FR
cassia bark oil china
FL/FR
clove bud oil
FL/FR
clove leaf absolute
FR
clove leaf oil
FL/FR
clove leaf resinoid
FR
croton eluteria bark oil
FL/FR
black
currant bud absolute
FL/FR
eugenol
FL/FR
galangal root oil
FL/FR
ginger infusions
FL/FR
ginger oleoresin
FL/FR
ginger oleoresin africa
FL/FR
ginger root absolute
FL/FR
ginger root essence
FL/FR
ginger root oil
FL/FR
ginger root oil brazil
FL/FR
ginger root oil china
FL/FR
ginger root oil CO2 extract
FL/FR
ginger root oil CO2 extract australia
FL/FR
ginger root oil cochin
FL/FR
ginger root oil terpeneless
FL/FR
ginger root oil terpeneless africa
FL/FR
nutmeg oil
FL/FR
pepper tree berry oil
FL/FR
snake root oil canada
FL/FR
turmeric root oil china
FL/FR
zingiber officinale extract
FL/FR
zingiber officinale root extract
FL/FR
zingiber officinale root tincture
FL/FR
terpenic
frankincense oil
FL/FR
juniperus communis fruit oil
FL/FR
alpha-
terpineol
FL/FR
tonka
tonka bean absolute
FR
tropical
curcuma amada roxb. rhizome oil CO2 extract
FL/FR
hotrienol
FL/FR
vanilla
ethyl vanillin
FL/FR
propenyl guaethol
FL/FR
vanilla bean absolute (vanilla planifolia)
FL/FR
vanillin
FL/FR
vanillyl acetate
FL/FR
waxy
1-
dodecanol
FL/FR
woody
amyris bark oil
FL/FR
atlas
cedarwood absolute
FR
patchouli ethanone
FR
sandal butenol
FR
santall
FR
santalum paniculatum wood oil
FR
spikenard oil
FL/FR
spruce needle oil canada
FL/FR
woody acetate
FR
(Z)-
woody amylene
FR
For Flavor
No flavor group found for these
amyris bark oil
FL/FR
peru balsam
FL
spikenard oil
FL/FR
anise
anise
(E)-
anethol
FL/FR
sweet
fennel seed oil
FL/FR
balsamic
peru balsam absolute
FL/FR
peru balsam resinoid
FL/FR
citrus
bergamot oil
FL/FR
bergamot oil bergaptene reduced italy
FL/FR
bergamot oil turkey
FL/FR
laevo-
linalool
FL/FR
linalool
FL/FR
nerol
FL/FR
sweet
orange peel oil c.p. brazil
FL/FR
petitgrain oil paraguay
FL/FR
alpha-
terpineol
FL/FR
creamy
gamma-
undecalactone (aldehyde C-14 (so-called))
FL/FR
veratraldehyde
FL/FR
dairy
methyl (Z)-5-octenoate
FL/FR
floral
iso
amyl phenyl acetate
FL/FR
bois de rose oil brazil
FL/FR
citronellol
FL/FR
geraniol
FL/FR
hotrienol
FL/FR
jasmin absolute (from pommade)
FL/FR
jasmin absolute egypt (from concrete)
FL/FR
jasmin absolute italy (from concrete)
FL/FR
linalyl acetate
FL/FR
methyl dihydrojasmonate
FL/FR
neryl acetate
FL/FR
ocean propanal
FL/FR
fruity
para-
anisyl alcohol
FL/FR
benzyl isobutyrate
FL/FR
ethyl heptanoate
FL/FR
styralyl acetate
FL/FR
green
cyclohexyl ethyl alcohol
FL/FR
dihydromyrcenol
FL/FR
geranyl acetate
FL/FR
(Z)-3-
hexen-1-ol
FL/FR
(Z)-3-
hexen-1-yl acetate
FL/FR
hexyl tiglate
FL/FR
2,4-
ivy carbaldehyde
FL/FR
linalool oxide
FL/FR
melon nonenoate
FL/FR
methyl heptenone
FL/FR
herbal
carum carvi fruit oil
FL/FR
clary sage oil france
FL/FR
coriander seed oil
FL/FR
lavender absolute bulgaria
FL/FR
honey
phenethyl acetate
FL/FR
meaty
ortho-
thioguaiacol
FL
phenolic
guaiacyl phenyl acetate
FL/FR
soapy
1-
dodecanol
FL/FR
spicy
allspice berry oil
FL/FR
allspice flavor
FL
allspice oil
FL/FR
alpinia galanga oil
FL/FR
alpinia galanga rhizome extract
FL/FR
alpinia galanga rhizome oil CO2 extract
FL/FR
siam
benzoin absolute
FL/FR
benzyl isoeugenol
FL/FR
cassia bark oil china
FL/FR
clove bud oil
FL/FR
clove leaf oil
FL/FR
croton eluteria bark oil
FL/FR
black
currant bud absolute
FL/FR
para-alpha-
dimethyl styrene
FL/FR
eugenol
FL/FR
galanga flavor
FL
galangal root oil
FL/FR
galangal root oleoresin
FL
ginger beer flavor
FL
ginger distillates
FL
ginger flavor
FL
ginger infusions
FL/FR
ginger oleoresin
FL/FR
ginger oleoresin africa
FL/FR
ginger root
FL
ginger root absolute
FL/FR
ginger root essence
FL/FR
ginger root oil
FL/FR
ginger root oil brazil
FL/FR
ginger root oil china
FL/FR
ginger root oil CO2 extract
FL/FR
ginger root oil CO2 extract australia
FL/FR
ginger root oil cochin
FL/FR
ginger root oil terpeneless
FL/FR
ginger root oil terpeneless africa
FL/FR
nutmeg oil
FL/FR
pepper tree berry oil
FL/FR
3-
phenyl propyl alcohol
FL/FR
snake root oil canada
FL/FR
turmeric root oil china
FL/FR
zingiber officinale extract
FL/FR
zingiber officinale root extract
FL/FR
zingiber officinale root tincture
FL/FR
terpenic
juniperus communis fruit oil
FL/FR
tropical
curcuma amada roxb. rhizome oil CO2 extract
FL/FR
vanilla
ethyl vanillin
FL/FR
propenyl guaethol
FL/FR
vanilla bean absolute (vanilla planifolia)
FL/FR
vanillin
FL/FR
vanillyl acetate
FL/FR
woody
amyris wood oil
FL/FR
frankincense oil
FL/FR
spruce needle oil canada
FL/FR
 
Potential Uses:
FRallspice
FRamber
FRbalsam
FRbutterscotch
FRcassia
FRchristmas
FRcoconut
FLcookie
 florida breeze
FRgardenia
FRginger
FLginger ale
FRginger white ginger
FRgingerbread
FRherbal
FRjasmin
FRlychee
 modifier
FRmoss
FRoriental
FRpumpkin pie
FRraspberry
FRsaffron
FL/FRsnake root
FRspice
FLtropical
FRvanilla
FRwoody
 
Occurrence (nature, food, other):note
 cranberry fruit
Search Trop Picture
 ginger oil
Search Trop Picture
 ginger rhizome
Search Trop Picture
 ginger rhizome oil
Search Trop Picture
 ginger root
Search Trop Picture
 ginger root oil
Search Trop Picture
 ginger root oil CO2 extract @ 2.26%
Data GC Search Trop Picture
 oregano shoot
Search Trop Picture
 origanum onites shoot
Search Trop Picture
 raspberry red raspberry fruit
Search Trop Picture
 
Synonyms:
 butan-2-one, 4-(4-hydroxy-3-methoxyphenyl)-
2-butanone, 4- (4-hydroxy-3-methoxyphenyl)-
2-butanone, 4-(4-hydroxy-3-methoxyphenyl)-
 ginger ketone
 gingerone
4-(4-hydroxy-3-methoxy-phenyl)-butan-2-one
4-hydroxy-3-methoxybenzyl acetone
4-hydroxy-3-methoxybenzylacetone
2-(4-hydroxy-3-methoxyphenyl ethyl) methyl ketone
4-(4-hydroxy-3-methoxyphenyl) butan-2-one
(4-hydroxy-3-methoxyphenyl) ethyl methyl ketone
2-(4-hydroxy-3-methoxyphenyl) ethyl methyl ketone
4-(4-hydroxy-3-methoxyphenyl)-2-butanone
4-(4-hydroxy-3-methoxyphenyl)butan-2-one
(4-hydroxy-3-methoxyphenyl)ethyl methyl ketone
2-(4-hydroxy-3-methoxyphenyl)ethyl methyl ketone
4-hydroxy-3-methyoxyphenyl ethyl methyl ketone
3-methoxy-4-hydroxy-benzylacetone
3-methoxy-4-hydroxybenzyl acetone
3-methoxy-4-hydroxybenzylacetone
4-(3-methoxy-4-hydroxyphenyl)-2-butanone
1-(3-methoxy-4-hydroxyphenyl)-3-butanone
[0]-paradol
 vanillyl acetone
 vanillylacetone
nat.zingerone
 zingerone cong. solid
 zingerone cryst. powder
 zingerone natural
 zingerone, natural
 zingherone
 zingiberone
 

Articles:

PubMed:Synthesis and quorum sensing inhibitory activity of key phenolic compounds of ginger and their derivatives.
PubMed:Ginger and its pungent constituents non-competitively inhibit serotonin currents on visceral afferent neurons.
PubMed:Zingerone attenuates lipopolysaccharide-induced acute lung injury in mice.
PubMed:Zingerone regulates intestinal transit, attenuates behavioral and oxidative perturbations in irritable bowel disorder in rats.
PubMed:Delayed administration of zingerone mitigates the behavioral and histological alteration via repression of oxidative stress and intrinsic programmed cell death in focal transient ischemic rats.
PubMed:Zingerone protects against stannous chloride-induced and hydrogen peroxide-induced oxidative DNA damage in vitro.
PubMed:Chemopreventive effect of zingerone against colon carcinogenesis induced by 1,2-dimethylhydrazine in rats.
PubMed:Anti-neuroinflammatory capacity of fresh ginger is attributed mainly to 10-gingerol.
PubMed:Zingerone inhibit biofilm formation and improve antibiofilm efficacy of ciprofloxacin against Pseudomonas aeruginosa PAO1.
PubMed:[Chemical constituents from leaves of Rhododendron rubiginosum var rubiginosum].
PubMed:Influence of ginger and cinnamon intake on inflammation and muscle soreness endued by exercise in Iranian female athletes.
PubMed:Zingerone enhances glutamatergic spontaneous excitatory transmission by activating TRPA1 but not TRPV1 channels in the adult rat substantia gelatinosa.
PubMed:Small molecules interacting with α-synuclein: antiaggregating and cytoprotective properties.
PubMed:Inhibition by capsaicin and its related vanilloids of compound action potentials in frog sciatic nerves.
PubMed:In vitro antifungal activity of dehydrozingerone and its fungitoxic properties.
PubMed:Synthesis of quinoline derivatives of tetrahydrocurcumin and zingerone and evaluation of their antioxidant and antibacterial attributes.
PubMed:Fenugreek extract as an inducer of cellular death via autophagy in human T lymphoma Jurkat cells.
PubMed:Ginger extract and zingerone ameliorated trinitrobenzene sulphonic acid-induced colitis in mice via modulation of nuclear factor-κB activity and interleukin-1β signalling pathway.
PubMed:Radioprotective effects of Zingiber officinale Roscoe (ginger): past, present and future.
PubMed:An overview on inventions related to ginger processing and products for food and pharmaceutical applications.
PubMed:Dietary administration of zingerone to enhance growth, non-specific immune response, and resistance to Vibrio alginolyticus in Pacific white shrimp (Litopenaeus vannamei) juveniles.
PubMed:Update on the chemopreventive effects of ginger and its phytochemicals.
PubMed:Characterization of raspberry ketone/zingerone synthase, catalyzing the alpha, beta-hydrogenation of phenylbutenones in raspberry fruits.
PubMed:Effects of zingerone [4-(4-hydroxy-3-methoxyphenyl)-2-butanone] and eugenol [2-methoxy-4-(2-propenyl)phenol] on the pathological progress in the 6-hydroxydopamine-induced Parkinson's disease mouse model.
PubMed:Intraluminal administration of zingerol, a non-pungent analogue of zingerone, inhibits colonic motility in rats.
PubMed:Protective effect of zingerone, a dietary compound against radiation induced genetic damage and apoptosis in human lymphocytes.
PubMed:Inhibitory effects of zingerone, a pungent component of Zingiber officinale Roscoe, on colonic motility in rats.
PubMed:Antagonistic effects of Zingerone, a phenolic alkanone against radiation-induced cytotoxicity, genotoxicity, apoptosis and oxidative stress in Chinese hamster lung fibroblast cells growing in vitro.
PubMed:Effects of various fragrant ingredients on desmopressin-induced fluid retention in mice.
PubMed:Modulation of age-related NF-kappaB activation by dietary zingerone via MAPK pathway.
PubMed:Radiomodifying and anticlastogenic effect of Zingerone on Swiss albino mice exposed to whole body gamma radiation.
PubMed:Peroxisome proliferator-activated receptor activation by a short-term feeding of zingerone in aged rats.
PubMed:Ginger-derived phenolic substances with cancer preventive and therapeutic potential.
PubMed:[Analysis of volatile and non-volatile compositions in ginger oleoresin by gas chromatography-mass spectrometry].
PubMed:Alkaloid and sesquiterpenes from the root tuber of Curcuma longa.
PubMed:Chemistry, antioxidant and antimicrobial investigations on essential oil and oleoresins of Zingiber officinale.
PubMed:[Effects of zingerone on fat storage in ovariectomized rats].
PubMed:Volatile composition in raspberry cultivars grown in the Pacific Northwest determined by stir bar sorptive extraction-gas chromatography-mass spectrometry.
PubMed:Manganese peroxidase-catalyzed oxidative degradation of vanillylacetone.
PubMed:Ginger and its bioactive component inhibit enterotoxigenic Escherichia coli heat-labile enterotoxin-induced diarrhea in mice.
PubMed:Temporal interactions between oral irritants: piperine, zingerone, and capsaicin.
PubMed:Biotransformation of raspberry ketone and zingerone by cultured cells of Phytolacca americana.
PubMed:Active spice-derived components can inhibit inflammatory responses of adipose tissue in obesity by suppressing inflammatory actions of macrophages and release of monocyte chemoattractant protein-1 from adipocytes.
PubMed:Cancer preventive properties of ginger: a brief review.
PubMed:Targeting antioxidative signal transduction and stress response system: control of pathogenic Aspergillus with phenolics that inhibit mitochondrial function.
PubMed:Controlling food-contaminating fungi by targeting their antioxidative stress-response system with natural phenolic compounds.
PubMed:Stimulatory actions of thymol, a natural product, on Ca(2+)-activated K(+) current in pituitary GH(3) cells.
PubMed:Antioxidant and free radical scavenging activities of Misodendrum punctulatum, myzodendrone and structurally related phenols.
PubMed:Zingerone as an antioxidant against peroxynitrite.
PubMed:Zingerone [4-(4-hydroxy-3-methoxyphenyl)-2-butanone] prevents 6-hydroxydopamine-induced dopamine depression in mouse striatum and increases superoxide scavenging activity in serum.
PubMed:Isolation of a natural antioxidant, dehydrozingerone from Zingiber officinale and synthesis of its analogues for recognition of effective antioxidant and antityrosinase agents.
PubMed:Identification of phenolics for control of Aspergillus flavus using Saccharomyces cerevisiae in a model target-gene bioassay.
PubMed:Inhibitory effect of ginger (Zingiber officinale) on rat ileal motility in vitro.
PubMed:Effects of terpenoid phenol derivatives on calcium current in canine and human ventricular cardiomyocytes.
PubMed:Individual differences in perception of bitterness from capsaicin, piperine and zingerone.
PubMed:Use of a fluorescent imaging plate reader--based calcium assay to assess pharmacological differences between the human and rat vanilloid receptor.
PubMed:Analysis of a ginger extract by high-performance liquid chromatography coupled to nuclear magnetic resonance spectroscopy using superheated deuterium oxide as the mobile phase.
PubMed:Insect growth inhibition, antifeedant and antifungal activity of compounds isolated/derived from Zingiber officinale Roscoe (ginger) rhizomes.
PubMed:Responses to repeated oral irritation by capsaicin, cinnamaldehyde and ethanol in PROP tasters and non-tasters.
PubMed:Different responses to repeated applications of zingerone in behavioral studies, recordings from intact and cultured TG neurons, and from VR1 receptors.
PubMed:Guaiacol and vanilloid compounds modulate the A-type potassium currents in molluscan neurons.
PubMed:The generalizability of capsaicin sensitization and desensitization.
PubMed:Induction of apoptosis in HL-60 cells by pungent vanilloids, [6]-gingerol and [6]-paradol.
PubMed:The influence of removing extracellular Ca2+ in the desensitization responses to capsaicin, zingerone and olvanil in rat trigeminal ganglion neurons.
PubMed:Rapid recovery from capsaicin desensitization during recurrent stimulation.
PubMed:Desensitization to oral zingerone irritation: effects of stimulus parameters.
PubMed:Similarities and differences in the currents activated by capsaicin, piperine, and zingerone in rat trigeminal ganglion cells.
PubMed:Psychophysical responses to single and multiple presentations of the oral irritant zingerone: relationship to frequency of chili consumption.
PubMed:Oxidation reactions catalyzed by manganese peroxidase isoenzymes from Ceriporiopsis subvermispora.
PubMed:Oxidase of the white rot fungus Panus tigrinus 8/18.
PubMed:Antioxidant actions of thymol, carvacrol, 6-gingerol, zingerone and hydroxytyrosol.
PubMed:Scavenging of superoxide anions by spice principles.
PubMed:Evidence that removal of capsaicin accelerates desensitization on the tongue.
PubMed:Differential inhibition of potassium currents in rat ventricular myocytes by capsaicin.
PubMed:Studies on spice principles as antioxidants in the inhibition of lipid peroxidation of rat liver microsomes.
PubMed:Heterologous expression of active manganese peroxidase from Phanerochaete chrysosporium using the baculovirus expression system.
PubMed:Characterization of vanilloid receptors in the dorsal horn of pig spinal cord.
PubMed:Antimicrobial effectiveness of six paradols. 1: A structure-activity relationship study.
PubMed:Some pungent principles of spices cause the adrenal medulla to secrete catecholamine in anesthetized rats.
PubMed:Mutagenicity of gingerol and shogaol and antimutagenicity of zingerone in Salmonella/microsome assay.
PubMed:A simple, sensitive method for detecting early peripheral nerve dysfunction in the rat following acrylamide treatment.
PubMed:The active part of the [6]-gingerol molecule in mutagenesis.
PubMed:Anaesthesia-like condition and/or potentiation of hexobarbital sleep produced by pungent agents in normal and capsaicin-desensitized rats.
PubMed:Stimulation of prostaglandin biosynthesis by drugs: effects in vitro of some drugs affecting gut function.
PubMed:The metabolism of zingerone, a pungent principle of ginger.
PubMed:Sensory effects of capsaicin congeners. Part II: Importance of chemical structure and pungency in desensitizing activity of capsaicin-type compounds.
PubMed:Homologs of dopa, alpha-methyldopa, and dopamine as potential cardiovascular drugs.
PubMed:[On o-vanillylacetone and its hydrogenation products with a contribution to hydrogenating amination of ketones].
 
Notes:
pungent principle of ginger. Reputed pungent principle of ginger (Zingiber officinale). Flavour material used in imitation fruit flavours, ginger beer, ginger ale etc. Also present in cranberry, raspberry and mango
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