mint lactone
  • CTC Organics
    • CTC Organics
      For More Than 40 Year
      Your source for rare aroma chemicals for the flavor and fragrance industy.
      “The world is run by middle men.” The number of times I have heard Dr. Liu utter those words are innumerable. He loved reciting and recording famous quotes and had many of his own. Among his many talents, Dr. Liu had a unique genius in the area of chemistry. He had an uncanny understanding of the pulse of the chemical industry and was a superb salesman.
      US Email: Customer Service
      US Voice: (404) 524-6744
      US Fax: (404) 577-1651
      W1366 mintlactone
  • Lluch Essence
    • Lluch Essence S.L.
      A family company dedicated to sales and distribution
      Flexibility, availability, price and quality.
      Flexibility, availability, price and quality make LLUCH ESSENCE S.L. one of Europe’s references when it comes to essential oils and aroma chemicals, and it is now well known all around the world.
      Email: Info
      Voice: 34 93 379 38 49
      Fax: 34 93 370 65 04
  • Penta International
    • Penta International Corporation
      Chemistry innovation
      At Penta, our products and services help businesses do business better.
      For over 30 years, Penta Manufacturing Company has played a growing role in worldwide chemistry innovations and applications. As an industry leader, Penta continues to pioneer chemistry-based solutions for practically every area of commerce. Our products and expertise have helped fuel technical advances in dozens of commercial applications including flavoring, coloring, fragrances and chemical processes.
      US Email: Technical Services
      US Email: Sales
      US Voice: (973) 740-2300
      US Fax: (973) 740-1839
      13-80300 MINT LACTONE, Kosher
  • SAFC Global
    • SAFC
      Complete Supply Chain
      The perfect blend of products and services that bring your creativity to life.
      Sigma-Aldrich is a leading Life Science and High Technology company dedicated to providing high-quality, safe and certified flavor ingredients with transparent and easily accessible documentation to customers around the globe. Sigma-Aldrich also provides a suite of analytical tools that allow food analysts to simplify sample preparation, cleanup and analysis steps, while increasing sensitivity to trace ingredients and harmful substances to meet regulations and quality standards.
      Email: Information
      US Email: Sales
      US Voice: 800-244-1173
      US Fax: 800-368-4661
      W376418 Menthalactone ≥99%, FG
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    Flavor Demo Formulas
3,6-dimethyl-5,6,7,7a-tetrahydro-4H-1-benzofuran-2-one (Click)
CAS Number: 13341-72-5 51744-94-6
ECHA EC Number: 236-390-6
MDL: MFCD00209516
FEMA Number: 3764
CoE Number: 10036
XlogP3-AA: 1.90 (est)
Molecular Weight: 166.21998000
Formula: C10 H14 O2
NMR Predictor: Predict
Category: flavor and fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist: Search
Google Patents: Search
US Patents: Search
EU Patents: Search
IBM Patents: Obtain
Pubchem Patents: Search
PubMed: Search
NCBI: Search
Read: Under the conditions of intended use - New developments in the FEMA GRAS program and the safety assessment of flavor ingredients
Read: A GRAS assessment program for flavor ingredients
Read: Sensory testing for flavorings with modifying properties. Food Technology
Read: Criteria for the safety evaluation of flavoring substances
Read: A procedure for the safety evaluation of natural flavor complexes used as ingredients in food: essential oils
Read: FEMA Expert Panel: 30 Years of safety evaluation for the flavor industry
Read: Consumption ratio and food predominance of flavoring materials
EFSA Update of results on the monitoring of furan levels in food: Read Report
EFSA Previous report: Results on the monitoring of furan levels in food: Read Report
EFSA Report of the CONTAM Panel on provisional findings on furan in food: Read Report
JECFA Food Flavoring: 1162  mintlactone
Flavis Number: 10.036 (Old)
EU SANCO Food Flavourings: 10.036  5,6,7,7a-tetrahydro-3,6-dimethylbenzofuran-2(4H)-one

FEMA Number: 3764  mintlactone
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Physical Properties:
Appearance: colorless clear liquid (est)
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Specific Gravity: 1.05800 @  25.00 °C.
Boiling Point: 87.00 to  89.00 °C. @ 25.00 mm Hg
Boiling Point: 302.00 to  303.00 °C. @ 760.00 mm Hg
Vapor Pressure: 0.001000 mm/Hg @ 25.00 °C. (est)
Flash Point: 176.00 °F. TCC ( 80.00 °C. )
logP (o/w): 1.811 (est)
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Organoleptic Properties:
Odor Type: tonka
Odor Strength: medium
Odor Description:
at 100.00 %. 
sweet creamy coumarin coconut powdery tobacco spearmint
Odor Description:
sweet, creamy, coumarinic and coconut with a powdery tobacco nuance
Mosciano, Gerard P&F 19, No. 3, 51, (1994)
Taste Description:
at 10.00 ppm.  
Creamy, coconut, sweet, vanilla and coumarin
Mosciano, Gerard P&F 19, No. 3, 51, (1994)
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: perfuming agents
Synonyms   Articles   Notes   Search   Top
CTC Organics
Lluch Essence
Penta International
Reincke & Fichtner
SAFC Global
≥99%, FG
Odor: cherry; creamy; minty; sweet
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Safety Information:
Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: flavor and fragrance agents
Recommendation for mint lactone usage levels up to:
  1.0000 % in the fragrance concentrate.
Maximised Survey-derived Daily Intakes (MSDI-EU): 3.50 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 9.00 (μg/capita/day)
Structure Class: III
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 15
Click here to view publication 15
 average usual ppmaverage maximum ppm
baked goods: --
beverages(nonalcoholic): -1.00000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: -20.00000
condiments / relishes: --
confectionery froastings: -5.00000
egg products: --
fats / oils: --
fish products: --
frozen dairy: --
fruit ices: --
gelatins / puddings: -2.00000
granulated sugar: --
gravies: --
hard candy: -5.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --
Synonyms   Articles   Notes   Search   Top
Safety References:
European Food Safety Athority(efsa): Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...
Flavor & Extract Manufacturers Association (FEMA) reference(s):
The FEMA GRAS assessment of lactones used as flavor ingredients.View pdf
EPI System: View Calculate predicted properties
EPA Substance Registry Services (TSCA): 13341-72-5
EPA ACToR: Toxicology Data
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 3
Chemidplus: 0013341725
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NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 13341-72-5
Pubchem (cid): 94349
Pubchem (sid): 135051602
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS): View
HMDB (The Human Metabolome Database): Search
Export Tariff Code: 2932.19.0000
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
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Potential Blenders and core components note
 acetoin acetateFL/FR
 acetyl butyrylFL/FR
 acetyl isobutyrylFL/FR
 acetyl isovalerylFL
 acetyl methyl anthranilateFL/FR
 acetyl nonyrylFL/FR
 acetyl propionylFL/FR
2-acetyl pyridineFL/FR
 allyl methyl trisulfideFL
 allyl nonanoateFL/FR
 amber decatrieneFR
 amber formateFR
 ambrette seed absoluteFL/FR
 ambrette seed oilFL/FR
alpha-amyl cinnamyl isovalerateFL/FR
 amyl heptanoateFL/FR
isoamyl octanoateFL/FR
 amyl phenyl acetateFL/FR
para-anisaldehyde / methyl anthranilate schiff's baseFR
para-anisyl acetateFL/FR
para-anisyl alcoholFL/FR
 anisyl propanal / methyl anthranilate schiff's baseFR
 beeswax absoluteFL/FR
 benzylidene acetoneFL
 boronia butenalFR
 bran absoluteFR
isobutyl benzoateFL/FR
isobutyl benzyl carbinolFL/FR
 butyl butyryl lactateFL/FR
 butyl lactateFL/FR
 butyl laevo-lactateFL/FR
 butyric acidFL/FR
2-oxobutyric acidFL/FR
alpha-cedrene epoxideFR
 chamomile flower oil germanyFL/FR
 cherry oxyacetateFL/FR
 cinnamyl alcoholFL/FR
 cocoa butenalFL/FR
 cocoa oleoresinFL/FR
 cocoa pentenalFL/FR
 coconut decanone methylFR
 coconut naphthalenoneFL/FR
 costus valerolactoneFR
 creamy lactoneFL/FR
para-cresyl isovalerateFL/FR
 cyclohexanone diethyl acetalFL/FR
 cyclohexyl acetic acidFL/FR
(Z)-dairy lactoneFL/FR
6-decenoic acidFL
 deertongue absoluteFR
 deertongue concrete 
 deertongue oleoresinFR
(R)-tonka furanoneFL
5,5-dibutyl dihydrofuran-2(3H)-oneFL
N,N-diethyl octanamideFR
 dihydrojasmone lactoneFL/FR
 dimethyl alpha-iononeFR
 dimethyl anthranilateFL/FR
 dimethyl benzofuranoneFL
ortho-dimethyl hydroquinoneFL/FR
 ethyl 3-hydroxyhexanoateFL/FR
 ethyl cinnamateFL/FR
 ethyl methyl-para-tolyl glycidateFL/FR
 ethyl palmitateFL/FR
3-ethyl pyridineFL/FR
 ethyl undecanoateFL/FR
 ethyl undecylenateFL/FR
 ethyl vanillinFL/FR
 ethyl vanillin isobutyrateFL/FR
 ethyl vanillin propylene glycol acetalFL/FR
 ethylene brassylateFL/FR
 farnesyl acetoneFL/FR
 fig leaf absoluteFL
 flouve absoluteFR
 genet absoluteFL/FR
 geranyl phenyl acetateFL/FR
 glyceryl 5-hydroxydecanoateFL/FR
 glyceryl 5-hydroxydodecanoateFL/FR
 guaiacwood oilFL/FR
 hay absoluteFR
 heliotropyl alcoholFL/FR
 heptanal 2,3-butane diol acetalFL
(Z)-4-heptenal diethyl acetalFL/FR
3-heptyl dihydro-5-methyl-2(3H)-furanoneFL/FR
 hexenyl cyclopentanoneFR
4-hydroxybenzyl alcoholFL/FR
 immortelle absoluteFL/FR
 jasmin lactoneFL/FR
 lauric acidFL/FR
 levulinic acidFL/FR
isolongifolene ketoneFR
 levisticum officinale oleoresinFL
 massoia bark oilFL
(R)-massoia lactoneFL
 yerba mate absoluteFL/FR
 methyl (Z)-5-octenoateFL/FR
 methyl 2-furoateFL/FR
 methyl 2-thiofuroateFL
para-methyl anisoleFL/FR
 methyl benzoxoleFL/FR
6-methyl coumarinFL
7-methyl coumarinCS
 methyl heptadienoneFL/FR
para-methyl hydratropaldehydeFL/FR
alpha-methyl iononeFL/FR
beta-isomethyl iononeFL/FR
alpha-isomethyl ionone (50% min.)FL/FR
alpha-isomethyl ionone (90% min.)FL/FR
 methyl ionyl acetateFL/FR
 methyl laurateFL/FR
 methyl nicotinateFL/FR
4-methyl octanoic acidFL/FR
6-methyl quinolineFL/FR
 musk amberolFR
 musk indaneFR
 musk tetralinFR
 myristyl alcoholFL/FR
beta-naphthyl ethyl etherFL/FR
gamma-nonalactone (aldehyde C-18 (so-called))FL/FR
 octyl 2-furoateFL
 octyl isobutyrateFL/FR
 orris rhizome resinoid (iris pallida)FL/FR
 paprika oleoresinFL
 peach pivalateFR
2-pentyl cyclopentanoneFR
 peru balsam oilFL/FR
 phenoxyethyl isobutyrateFL/FR
 phenyl acetic acidFL/FR
 pine needle absoluteFL/FR
 powdery ketoneFL
 propenyl guaetholFL/FR
 propyl octanoateFL/FR
isopropyl octanoateFL/FR
isopropyl phenyl acetateFL/FR
2-propyl pyridineFL
 rhodinyl phenyl acetateFL/FR
 saffron indenoneFL/FR
 saffron resinoidFL/FR
(+)-alpha-santalyl acetateFL/FR
 strawberry furanone acetateFL/FR
 timber propanolFR
 tobacco butenalFR
 tobacco concreteFR
(E,E/E,Z)-tobacco cyclohexenoneFL/FR
 tobacco flower absoluteFR
 tobacco leaf absoluteFL/FR
 tobacco noneneFR
 tolualdehydes (mixed o,m,p)FL/FR
 tonka bean absoluteFR
 tonka bean oleoresinFR
 tonka bean resinoidFR
 tonka furanoneFL/FR
 tonka ketoneFR
 tonka undecanoneFR
2,3,5-trimethyl pyrazineFL/FR
gamma-undecalactone (aldehyde C-14 (so-called))FL/FR
 undecanoic acidFL/FR
 vanilla oleoresin baliFL/FR
para-vanillic acidFL/FR
 vanillyl acetateFL/FR
para-vanillyl alcoholFL/FR
 vanillyl isobutyrateFL/FR
 vanillylidene acetoneFL/FR
 vetiveryl acetateFL/FR
 whiskey lactoneFL/FR
 wine lactoneFL/FR
 woodruff absoluteFR
 woody dioxolaneFR
 woody epoxideFR
 woody etherFR
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Potential Uses:
Synonyms   Articles   Notes   Search   Top
Natural Occurrence in: note
 mentha arvensis
GRIN Trop Picture
 pennyroyal oil
GRIN Trop Picture
GRIN Trop Picture
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2(4H)-benzofuranone, 5,6,7,7a-tetrahydro-3,6-dimethyl-
 mint furanone
 mint lactone
 tetrahydrodimethyl benzofuran-2-one
Synonyms   Articles   Notes   Search   Top
PubMed: Protein kinase and HDAC inhibitors from the endophytic fungus Epicoccum nigrum.
PubMed: Bioactivities of some essential oils against the camel nasal botfly, Cephalopina titillator.
PubMed: Two new monoterpenes from the fruits of Illicium lanceolatum.
PubMed: Chemical composition of the essential oil from Corsican Mentha aquatica--combined analysis by GC(RI), GC-MS and 13C NMR spectroscopy.
PubMed: Anti-Candida activity of Mentha arvensis and Turnera ulmifolia.
PubMed: Tolerability of everolimus-based immunosuppression in maintenance liver transplant recipients.
PubMed: Differential proteome and phosphoproteome signatures in human T-lymphoblast cells induced by sirolimus.
PubMed: Menthalactone, a new analgesic from Mentha cordifolia Opiz. Leaves.
PubMed: Synthetic studies on neoclerodane diterpenes from Salvia splendens: oxidative modifications of ring A.
PubMed: The antimicrobial activity of four commercial essential oils in combination with conventional antimicrobials.
PubMed: Pharmacokinetics, efficacy, and safety of mycophenolate mofetil in combination with standard-dose or reduced-dose tacrolimus in liver transplant recipients.
PubMed: Nitration versus nitrosation chemistry of menthofuran: remarkable fragmentation and dimerization pathways and expeditious entry into dehydromenthofurolactone.
PubMed: Conversion to sirolimus-based immunosuppression in maintenance liver transplantation patients.
PubMed: Use of a superabsorbent polymer for the preconcentration of volatile components from complex matrices.
PubMed: Long-term renal function after liver transplantation is related to calcineurin inhibitors blood levels.
PubMed: Antidiarrhoeal activity of some Egyptian medicinal plant extracts.
PubMed: Immunosuppression for pancreatic islet transplantation.
PubMed: Lactones. 21. Synthesis and odoriferous properties of lactones with the p-menthane system.
PubMed: Munc18 interacting proteins: ADP-ribosylation factor-dependent coat proteins that regulate the traffic of beta-Alzheimer's precursor protein.
PubMed: Hepatitis associated with Kava, a herbal remedy for anxiety.
PubMed: A generalist herbivore in a specialist mode Metabolic, sequestrative, and defensive consequences.
PubMed: Metabolism of Monoterpenes : Evidence for the Function of Monoterpene Catabolism in Peppermint (Mentha piperita) Rhizomes.
PubMed: Metabolism of Monoterpenes : Early Steps in the Metabolism of d-Neomenthyl-beta-d-Glucoside in Peppermint (Mentha piperita) Rhizomes.
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Picture of molecule
Soluble in:
 water, slightly
 water, 725.4 mg/L @ 25 °C (est)
Insoluble in:
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