EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

heliotropin
piperonal

Sponsors

Fragrance Demo Formulas
Flavor Demo Formulas
Name:1,3-benzodioxole-5-carbaldehyde
CAS Number: 120-57-0Picture of molecule3D/inchi
Other:30024-74-9
ECHA EINECS - REACH Pre-Reg:204-409-7
FDA UNII:KE109YAK00
Nikkaji Web:J2.919J
Beilstein Number:131691
MDL:MFCD00005828
CoE Number:104
XlogP3:1.10 (est)
Molecular Weight:150.13342000
Formula:C8 H6 O3
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
EFSA/JECFA Comments:
ADI: 0-2.5 (JECFA, 1968).
Category:cosmetic, flavor and fragrance agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
JECFA Food Flavoring:896 piperonal
FLAVIS Number:05.016 (Old)
DG SANTE Food Flavourings:05.016 piperonal
FEMA Number:2911 piperonal
FDA:No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm: PIPERONAL
FDA Regulation:
FDA PART 182 -- SUBSTANCES GENERALLY RECOGNIZED AS SAFE
Subpart A--General Provisions
Sec. 182.60 Synthetic flavoring substances and adjuvants.
 
Physical Properties:
Appearance:white crystalline powder (est)
Assay: 98.00 to 100.00
Heavey Metals:<40.00 ppm
Food Chemicals Codex Listed: Yes
Melting Point: 37.00 to 39.00 °C. @ 760.00 mm Hg
Boiling Point: 263.00 to 265.00 °C. @ 760.00 mm Hg
Boiling Point: 144.00 to 145.00 °C. @ 15.00 mm Hg
Congealing Point:35.30 °C.
Acid Value: 3.00 max. KOH/g
Vapor Pressure:0.003000 mm/Hg @ 25.00 °C.
Flash Point:> 230.00 °F. TCC ( > 110.00 °C. )
logP (o/w): 1.050
Shelf Life: 24.00 month(s) or longer if stored properly.
Storage:store in cool, dry place in tightly sealed containers, protected from heat and light.
Soluble in:
 alcohol
 benzyl benzoate
 dipropylene glycol
 fixed oils
 isopropyl myristate
 propylene glycol
 water, 3500 mg/L @ 25 °C (exp)
Insoluble in:
 paraffin oil
 glycerin
Stability:
 bath foam
 hair spray
 powder
 soap
 
Organoleptic Properties:
Odor Type: floral
Odor Strength:medium
Substantivity:212 hour(s) at 100.00 %
heliotrope sweet powdery coconut vanilla
Odor Description:at 100.00 %. heliotrope flower sweet powdery coconut vanilla
Luebke, William tgsc, (1982)
Odor sample from: Berje Inc.
cherry vanilla sweet cherry maraschino cherry creamy cinnamyl
Odor Description:Cherry, vanilla, sweet cherry pit notes and creamy with cinnamic nuances
Mosciano, Gerard P&F 21, No. 5, 49, (1996)
Flavor Type: cherry
cherry maraschino cherry cherry vanilla spicy
Taste Description: at 15.00 ppm. Benzaldehyde, cherry, vanilla and spicy
Mosciano, Gerard P&F 21, No. 5, 49, (1996)
Odor and/or flavor descriptions from others (if found).
Takasago
Heliotropin 99% as Piperonal
Odor Description:Cherry-like
Widely used in perfumery. Used in powdery accords, but also in florals, like muguet, carnation, and lilac. Give softness and creaminess.
Taste Description:sweet creamy nutty benzaldehyde vanilla spice
Sigma-Aldrich
Piperonal, ≥99%, FCC, FG
Odor Description:almond; anise; balsam; berry; cherry; creamy; floral; raspberry; sweet; vanilla; violet; woody; wine-like; herbaceous
Taste Description:sweet creamy nutty benzaldehyde vanilla spice
Moellhausen
PIPERONAL
Odor Description:sweet, vanilla
Taste Description:sweet, aromatic, vanilla, benzaldehyde
Alfrebro
Heliotropin, Natural
Odor Description:Heliotrope Flower Sweet Coconut
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: masking agents
perfuming agents
skin conditioning
 
Suppliers:
Advanced Biotech
HELIOTROPINE NATURAL
98% min.
Advanced Biotech
HELIOTROPINE SYNTHETIC
Alfrebro
Heliotropin, Natural
Odor: Heliotrope Flower Sweet Coconut
Associate Allied Chemicals
Heliotropin
About
Aurochemicals
HELIOTROPINE, Natural
Axxence Aromatic
HELIOTROPIN Natural
Kosher
Sustainability
Bell Flavors & Fragrances
Heliotropine
Bell Flavors & Fragrances
Natural Heliotropine (EU)
Bell Flavors & Fragrances
Natural Heliotropine
Berjé
Heliotropine
Happening at Berje
BOC Sciences
For experimental / research use only.
Piperonal
Bontoux
HELIOTROPINE
Charkit Chemical
PIPERONAL
Citrus and Allied Essences
Heliotropin Recrystallized Extra FCC
Market Report
Ernesto Ventós
PIPERONAL (HELIOTROPINE)
Odor: SWEET, FLORAL
Excellentia International
Heliotropin Natural
Fleurchem
heliotropin natural
Fleurchem
heliotropin
Frinton Laboratories
For experimental / research use only.
Piperonal
Global Essence
Heliotropine
Indenta Group
Heliotropin
Indukern F&F
PIPERONAL
Odor: SWEET, VANILLA
Lluch Essence
PIPERONAL NATURAL
Lluch Essence
PIPERONAL
M&U International
HELIOTROPIN
M&U International
NAT. HELIOTROPIN
Moellhausen
HELIOBASE (25%PG)
Moellhausen
HELIOBASE (30% PG)
Moellhausen
HELIOBASE (30%DPG)
Odor: sweet, vanilla
Moellhausen
HELIOBASE (43% DIACETIN)
Moellhausen
HELIOBASE (50% TRIACETINA)
Moellhausen
HELIOBASE (50%DPG)
Odor: sweet, vanilla
Moellhausen
HELIOBASE (50%PG)
Moellhausen
HELIOBASE 14%PG
Moellhausen
HELIOBASE 50% IPM
Moellhausen
PIPERONAL
Odor: sweet, vanilla
Flavor: sweet, aromatic, vanilla, benzaldehyde
O'Laughlin Industries
HELIOTROPINE US NATURAL
OQEMA
Heliotropin
PCW France
Heliotropin
Steps to a fragranced product
Penta International
HELIOTROPIN, Kosher
Penta International
HELIOTROPIN, NATURAL, Kosher
Perfumer Supply House
Heliotropin Crystals (Piperonal) – for a limited time only
Phoenix Aromas & Essential Oils
Heliotropine Natural
Phoenix Aromas & Essential Oils
Heliotropine
Prinova
Heliotropin
Reincke & Fichtner
Heliotropin natural
Reincke & Fichtner
Heliotropin
Sigma-Aldrich
Piperonal, ≥99%, FCC, FG
Odor: almond; anise; balsam; berry; cherry; creamy; floral; raspberry; sweet; vanilla; violet; woody; wine-like; herbaceous
Certified Food Grade Products
Sigma-Aldrich
Piperonal, natural, 98%, FG
Odor: floral
SRS Aromatics
HELIOTROPIN
Symphony Pharma
For experimental / research use only.
benzo[d][1,3]dioxole-5-carbaldehyde
Takasago
Heliotropin
99% as Piperonal
Odor: Cherry-like
Use: Widely used in perfumery. Used in powdery accords, but also in florals, like muguet, carnation, and lilac. Give softness and creaminess.
The Fragrance Museum
The John D. Walsh Company
Heliotropine
Treatt
Heliotropine
Vigon International
Heliotropine Crystals Synthetic ex Sassafras
Vigon International
Heliotropine Crystals
Vigon International
Heliotropine Natural
WEN International
HELIOTROPIN Natural
 
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
Xi - Irritant
R 36/37/38 - Irritating to eyes, respiratory system, and skin.
S 02 - Keep out of the reach of children.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36 - Wear suitable protective clothing.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
Skin irritation (Category 2), H315
Acute aquatic toxicity (Category 3), H402
Chronic aquatic toxicity (Category 3), H412
GHS Label elements, including precautionary statements
 
Pictogramexclamation-mark.jpg
 
Signal word Warning
Hazard statement(s)
H315 - Causes skin irritation
H402 - Harmful to aquatic life
H412 - Harmful to aquatic life with long lasting effects
Precautionary statement(s)
P264 - Wash skin thouroughly after handling.
P273 - Avoid release to the environment.
P280 - Wear protective gloves/protective clothing/eye protection/face protection.
P302 + P352 - IF ON SKIN: wash with plenty of soap and water.
P332 + P313 - IF SKIN irritation occurs: Get medical advice/attention.
P362 - Take off contaminated clothing and wash before reuse.
P501 - Dispose of contents/ container to an approved waste disposal plant.
Human Experience:
6 % solution: no irritation or sensitization.
Oral/Parenteral Toxicity:
gavage-rat LD50 [sex: M,F] 2700 mg/kg
(Jenner et al., 1964)

gavage-rat LD50 [sex: M,F] 2700 mg/kg
(Taylor et al., 1964)

gavage-rat LD50 [sex: M,F] 2700 mg/kg
(Hagan et al., 1965)

intraperitoneal-mouse LD50 480 mg/kg
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 43, Pg. 370, 1954.

oral-rat LD50 2700 mg/kg
BEHAVIORAL: EXCITEMENT BEHAVIORAL: ATAXIA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Toxicology and Applied Pharmacology. Vol. 6, Pg. 378, 1964.

intraperitoneal-rat LDLo 1500 mg/kg
BEHAVIORAL: ATAXIA BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Revue Medicale de la Suisse Romande. Vol. 16, Pg. 449, 1896.

Dermal Toxicity:
skin-rabbit LD50 > 5000 mg/kg
National Technical Information Service. Vol. OTS0535062

skin-rat LD50 > 5 mg/kg
National Technical Information Service. Vol. OTS0535062

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: cosmetic, flavor and fragrance agents
Recommendation for heliotropin usage levels up to:
  8.0000 % in the fragrance concentrate.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 1500.00 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 3200.00 (μg/capita/day)
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
 average usual ppmaverage maximum ppm
baked goods: -18.00000
beverages(nonalcoholic): -6.00000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: -36.00000
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: -7.00000
fruit ices: -7.00000
gelatins / puddings: -5.80000
granulated sugar: --
gravies: --
hard candy: -7.40000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --
 
Safety References:
European Food Safety Athority(efsa):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the Commission related to Flavouring Group Evaluation 20 (FGE.20): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical group 23
View page or View pdf

Flavouring Group Evaluation 52 (FGE.52): Consideration of hydroxy- and alkoxy-substituted benzyl derivatives evaluated by JECFA (57th meeting) structurally related to benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters evaluated by EFSA in FGE.20 (2005) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf

Flavouring Group Evaluation 54 (FGE.54)[1] - Consideration of benzyl derivatives evaluated by JECFA (57th meeting) structurally related to benzyl alcohols, benzaldehydes, a related acetal, benzoic acids and related esters evaluated by EFSA in FGE.20 (2005) - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food
View page or View pdf

Flavouring Group Evaluation 20, Revision 1 (FGE.20Rev1): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids and related esters from chemical group 23
View page or View pdf

Flavouring Group Evaluation 54, Revision 1 (FGE.54Rev1): Consideration of benzyl derivatives evaluated by JECFA (57th meeting) structurally related to benzyl alcohols, benzaldehydes, a related acetal, benzoic acids and related esters evaluated by EFSA in FGE.20Rev1 (2009)
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 20, Revision 2 (FGE.20Rev2): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical groups 23 and 30
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 20, Revision 3(FGE.20Rev3): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical groups 23 and 30
View page or View pdf

EPI System: View
NLM Hazardous Substances Data Bank:Search
Chemical Carcinogenesis Research Information System:Search
Cancer Citations:Search
Toxicology Citations:Search
Env. Mutagen Info. Center:Search
EPA Substance Registry Services (TSCA):120-57-0
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :8438
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
1,3-benzodioxole-5-carbaldehyde
Chemidplus:0000120570
EPA/NOAA CAMEO:hazardous materials
RTECS:TO1575000 for cas# 120-57-0
 
References:
 1,3-benzodioxole-5-carbaldehyde
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:120-57-0
Pubchem (cid):8438
Pubchem (sid):134975051
Pherobase:View
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS):View
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C10812
HMDB (The Human Metabolome Database):HMDB32612
FooDB:FDB010553
YMDB (Yeast Metabolome Database):YMDB01776
Export Tariff Code:2932.93.0000
Haz-Map:View
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
RSC Learn Chemistry:View
Formulations/Preparations:
grades: technical; fcc
 
Potential Blenders and core components note
For Odor
acidic
cyclohexyl acetic acid
FL/FR
aldehydic
decanal (aldehyde C-10)
FL/FR
dodecanal (aldehyde C-12 lauric)
FL/FR
10-
undecenal (aldehyde C-11 undecylenic)
FL/FR
amber
cistus ladaniferus resinoid
FR
animal
animal carbolactone
FR
costus valerolactone
FR
indole
FL/FR
anise
anise seed oil colombia
FL/FR
anisic
ortho-
acetanisole
FL/FR
para-
acetanisole
FL/FR
ambrette seed oil
FL/FR
para-
anisaldehyde
FL/FR
ortho-
anisaldehyde
FL/FR
balsamic
2-
acetyl furan
FL/FR
iso
amyl benzoate
FL/FR
amyris wood oil
FL/FR
sumatra
benzoin resin
FL/FR
sumatra
benzoin resinoid
FL/FR
siam
benzoin resinoid
FL/FR
benzophenone
FR
benzyl cinnamate
FL/FR
benzyl salicylate
FL/FR
iso
butyl benzoate
FL/FR
iso
butyl cinnamate
FL/FR
cinnamyl alcohol
FL/FR
cinnamyl cinnamate
FL/FR
clover nitrile
FR
copaiba balsam oil
FL/FR
ethyl cinnamate
FL/FR
fir balsam absolute
FR
methyl (E)-cinnamate
FL/FR
methyl cinnamate
FL/FR
myrrh oil
FL/FR
peru balsam oil
FL/FR
3-
phenyl propyl alcohol
FL/FR
iso
propyl cinnamate
FL/FR
tolu balsam
FL/FR
tolu balsam oil
FL/FR
berry
raspberry ketone
FL/FR
caramellic
cyclotene
FL/FR
ethyl maltol
FL/FR
immortelle absolute
FL/FR
maltol
FL/FR
strawberry furanone
FL/FR
chocolate
iso
amyl phenyl acetate
FL/FR
cocoa oleoresin
FL/FR
cocoa pentenal
FL/FR
vanillyl ethyl ether
FL/FR
citrus
bergamot oil
FL/FR
blood
orange oil italy
FL/FR
coconut
gamma-
heptalactone
FL/FR
gamma-
nonalactone (aldehyde C-18 (so-called))
FL/FR
gamma-
octalactone
FL/FR
coumarinic
phthalide
FL/FR
creamy
geranyl ethyl acetal
FR
para-
vanillic acid
FL/FR
para-
vanillyl alcohol
FL/FR
fatty
decanol
FL/FR
floral
acetophenone
FL/FR
allyl anthranilate
FL/FR
alpha-
amyl cinnamaldehyde
FL/FR
iso
amyl salicylate
FL/FR
para-
anisaldehyde / methyl anthranilate schiff's base
FR
anisyl propanal / methyl anthranilate schiff's base
FR
benzyl acetate
FL/FR
benzyl alcohol
FL/FR
cinnamyl phenyl acetate
FL/FR
citronellol
FL/FR
para-
cresyl propionaldehyde
CS
cyclohexyl ethyl alcohol
FL/FR
alpha-
damascone
FL/FR
dihydrojasmone
FL/FR
dimethyl alpha-ionone
FR
dimethyl anthranilate
FL/FR
dimethyl benzyl carbinol
FL/FR
dimethyl benzyl carbinyl butyrate
FL/FR
ethyl phenyl acetate
FL/FR
floral pyranol
FR
geraniol
FL/FR
(E)-
geranyl acetone
FL/FR
geranyl phenyl acetate
FL/FR
heliotrope absolute
FR
heliotrope fragrance
FR
heliotrope specialty
FR
heliotropyl acetate
FL/FR
heliotropyl acetone
FL/FR
heliotropyl diethyl acetal
FR
alpha-
hexyl cinnamaldehyde
FL/FR
hyacinth ether
FR
hydroxycitronellal
FL/FR
(E)-beta-
ionone
FL/FR
alpha-
irone
FL/FR
linalool oxide
FL/FR
para-
methyl acetophenone
FL/FR
methyl dihydrojasmonate
FL/FR
beta-iso
methyl ionone
FL/FR
alpha-iso
methyl ionone (50% min.)
FL/FR
alpha-iso
methyl ionone (90% min.)
FL/FR
methyl ionyl acetate
FL/FR
mimosa heptanal
FR
neroli oil bigarde
FL/FR
nerolidol
FL/FR
orris pyridine 25% IPM
FR
orris rhizome resinoid (iris pallida)
FL/FR
peony alcohol
FR
phenethyl alcohol
FL/FR
phenethyl phenyl acetate
FL/FR
4-
phenyl-2-butanol
FL/FR
iso
propyl phenyl acetate
FL/FR
rhodinol
FL/FR
rhodinyl phenyl acetate
FL/FR
rose absolute (rosa damascena) bulgaria
FL/FR
rose butanoate
FL/FR
(E)-2,5,9-
trimethyl-4,9-decadien-1-al
FR
tuberose absolute (from pommade)
FL/FR
fresh
10-
undecen-1-yl acetate
FL/FR
fruity
acetyl methyl anthranilate
FL/FR
bitter
almond oil
FL/FR
benzaldehyde
FL/FR
benzaldehyde glycrol acetal
FL/FR
bread thiophene
FL/FR
cherry oxyacetate
FL/FR
cinnamyl isobutyrate
FL/FR
beta-
damascone
FL/FR
gamma-
decalactone
FL/FR
ethyl methyl-para-tolyl glycidate
FL/FR
heliotropyl isobutyrate
FL/FR
hexyl isovalerate
FL/FR
peach pivalate
FR
prenyl acetate
FL/FR
prunus amygdalus amara seed extract
FL/FR
tolualdehydes (mixed o,m,p)
FL/FR
gamma-
undecalactone (aldehyde C-14 (so-called))
FL/FR
green
benzaldehyde dimethyl acetal
FL/FR
(Z)-3-
hexen-1-yl acetate
FL/FR
(Z)-3-
hexen-1-yl butyrate
FL/FR
(Z)-3-
hexen-1-yl propionate
FL/FR
(E)-2-
hexen-1-yl propionate
FL/FR
para-
methyl hydratropaldehyde
FL/FR
phenoxyethyl isobutyrate
FL/FR
3-
phenyl propionaldehyde
FL/FR
hay
beeswax absolute
FL/FR
hay absolute
FR
herbal
clary sage oil france
FL/FR
lavender absolute bulgaria
FL/FR
honey
phenyl acetic acid
FL/FR
medicinal
2-
hydroxybenzaldehyde
FL/FR
melon
watermelon ketone
FR
mossy
veramoss (IFF)
FR
musk
cyclohexadecanone
FR
ethylene brassylate
FL/FR
exaltone (Firmenich)
FR
3-
methyl-6-cyclohexadecen-1-one
FR
dextro,laevo-
muscone
FL/FR
musk amberol
FR
musk indane
FR
musk tetralin
FR
omega-
pentadecalactone
FL/FR
musty
cocoa butenal
FL/FR
naphthyl
2,4-
dimethyl benzaldehyde
FL/FR
para-
methyl anisole
FL/FR
beta-
naphthyl ethyl ether
FL/FR
nutty
2,3,5-
trimethyl pyrazine
FL/FR
phenolic
methyl benzoate
FL/FR
powdery
para-
anisyl acetate
FL/FR
para-
anisyl alcohol
FL/FR
applelide (IFF)
FR
alpha-
methyl ionone
FL/FR
smoky
2,6-
dimethoxyphenol
FL/FR
spicy
allspice oil
FL/FR
amyl isoeugenol
FR
para-
anisyl formate
FL/FR
benzyl isoeugenol
FL/FR
cassia bark oil china
FL/FR
cinnamon bark oil (cinnamomum zeylanicum) india
FL/FR
clove bud oil
FL/FR
elettaria cardamomum seed oil
FL/FR
iso
eugenyl acetate
FL/FR
ortho-
methoxycinnamaldehyde
FL/FR
alpha-
methyl cinnamaldehyde
FL/FR
4-
methyl guaiacol
FL/FR
methyl isoeugenol
FL/FR
black
poplar bud absolute
FR
sweet
vanilla oleoresin bali
FL/FR
terpenic
frankincense oil
FL/FR
alpha-
terpineol
FL/FR
tonka
coumarin
FR
deertongue absolute
FR
gamma-
hexalactone
FL/FR
mint lactone
FL/FR
tonka bean absolute
FR
vanilla
ortho-
dimethyl hydroquinone
FL/FR
ethyl vanillin
FL/FR
ethyl vanillin hexylene glycol acetal
FR
ethyl vanillin isobutyrate
FL/FR
ethyl vanillin propylene glycol acetal
FL/FR
heliotropyl alcohol
FL/FR
vanilla bean absolute (vanilla planifolia)
FL/FR
vanillin
FL/FR
vanillyl acetate
FL/FR
vanillyl isobutyrate
FL/FR
vanillylidene acetone
FL/FR
waxy
decyl acetate
FL/FR
1-
dodecanol
FL/FR
woody
amber formate
FR
anthocephalus cadamba oil
FR
guaiacwood oil
FL/FR
gurjun balsam oil
FR
patchouli ethanone
FR
patchouli oil
FL/FR
santall
FR
(+)-alpha-
santalyl acetate
FL/FR
timber propanol
FR
tobacarol (IFF)
FR
vetiveryl acetate
FL/FR
woody acetate
FR
(Z)-
woody amylene
FR
woody epoxide
FR
woody propanol
FR
For Flavor
No flavor group found for these
allyl anthranilate
FL/FR
ambrette seed oil
FL/FR
cinnamyl phenyl acetate
FL/FR
ortho-
dimethyl hydroquinone
FL/FR
heliotropyl alcohol
FL/FR
methyl (E)-cinnamate
FL/FR
beta-iso
methyl ionone
FL/FR
rose absolute (rosa damascena) bulgaria
FL/FR
(+)-alpha-
santalyl acetate
FL/FR
vetiveryl acetate
FL/FR
beta-
damascone
FL/FR
animal
animal
indole
FL/FR
anise
anise seed oil colombia
FL/FR
anisic
para-
acetanisole
FL/FR
ortho-
anisaldehyde
FL/FR
balsamic
sumatra
benzoin resin
FL/FR
siam
benzoin resinoid
FL/FR
sumatra
benzoin resinoid
FL/FR
benzyl salicylate
FL/FR
iso
butyl cinnamate
FL/FR
copaiba balsam oil
FL/FR
ethyl cinnamate
FL/FR
myrrh oil
FL/FR
peru balsam oil
FL/FR
iso
propyl cinnamate
FL/FR
tolu balsam
FL/FR
tolu balsam oil
FL/FR
vanillylidene acetone
FL/FR
berry
heliotropyl acetone
FL/FR
raspberry ketone
FL/FR
brown
beeswax absolute
FL/FR
caramellic
caramel furanone
FL
cyclotene
FL/FR
ethyl maltol
FL/FR
maltol
FL/FR
strawberry furanone
FL/FR
chocolate
cocoa oleoresin
FL/FR
citrus
bergamot oil
FL/FR
blood
orange oil italy
FL/FR
alpha-
terpineol
FL/FR
coconut
6-
methyl coumarin
FL
gamma-
nonalactone (aldehyde C-18 (so-called))
FL/FR
coumarinic
phthalide
FL/FR
creamy
para-
anisaldehyde
FL/FR
gamma-
hexalactone
FL/FR
para-
methyl acetophenone
FL/FR
mint lactone
FL/FR
gamma-
undecalactone (aldehyde C-14 (so-called))
FL/FR
para-
vanillic acid
FL/FR
para-
vanillyl alcohol
FL/FR
fatty
10-
undecenal (aldehyde C-11 undecylenic)
FL/FR
floral
2-
acetyl-5-methyl thiophene
FL
iso
amyl phenyl acetate
FL/FR
citronellol
FL/FR
cocoa pentenal
FL/FR
dihydrojasmone
FL/FR
dimethyl benzyl carbinyl butyrate
FL/FR
geraniol
FL/FR
(E)-
geranyl acetone
FL/FR
geranyl phenyl acetate
FL/FR
heliotropyl acetate
FL/FR
methyl dihydrojasmonate
FL/FR
alpha-iso
methyl ionone (50% min.)
FL/FR
alpha-iso
methyl ionone (90% min.)
FL/FR
neroli oil bigarde
FL/FR
orris rhizome resinoid (iris pallida)
FL/FR
phenethyl alcohol
FL/FR
phenyl acetic acid
FL/FR
4-
phenyl-2-butanol
FL/FR
rhodinol
FL/FR
tuberose absolute (from pommade)
FL/FR
fruity
acetyl methyl anthranilate
FL/FR
bitter
almond oil
FL/FR
iso
amyl benzoate
FL/FR
para-
anisyl acetate
FL/FR
para-
anisyl alcohol
FL/FR
benzaldehyde
FL/FR
benzaldehyde glycrol acetal
FL/FR
benzyl acetate
FL/FR
benzyl alcohol
FL/FR
bread thiophene
FL/FR
iso
butyl benzoate
FL/FR
cherry oxyacetate
FL/FR
cinnamyl isobutyrate
FL/FR
alpha-
damascone
FL/FR
gamma-
decalactone
FL/FR
dimethyl anthranilate
FL/FR
ethyl methyl-para-tolyl glycidate
FL/FR
heliotropyl isobutyrate
FL/FR
alpha-
methyl ionone
FL/FR
prenyl acetate
FL/FR
rose butanoate
FL/FR
tolualdehydes (mixed o,m,p)
FL/FR
greasy
10-
undecen-1-yl acetate
FL/FR
green
iso
amyl salicylate
FL/FR
benzaldehyde dimethyl acetal
FL/FR
cinnamyl alcohol
FL/FR
cocoa butenal
FL/FR
cyclohexyl ethyl alcohol
FL/FR
(Z)-3-
hexen-1-yl acetate
FL/FR
(Z)-3-
hexen-1-yl butyrate
FL/FR
(Z)-3-
hexen-1-yl propionate
FL/FR
(E)-2-
hexen-1-yl propionate
FL/FR
hexyl isovalerate
FL/FR
immortelle absolute
FL/FR
linalool oxide
FL/FR
para-
methyl hydratropaldehyde
FL/FR
nerolidol
FL/FR
phenoxyethyl isobutyrate
FL/FR
3-
phenyl propionaldehyde
FL/FR
herbal
clary sage oil france
FL/FR
lavender absolute bulgaria
FL/FR
honey
ethyl phenyl acetate
FL/FR
phenethyl phenyl acetate
FL/FR
iso
propyl phenyl acetate
FL/FR
lactonic
gamma-
heptalactone
FL/FR
gamma-
octalactone
FL/FR
meaty
ortho-
thioguaiacol
FL
medicinal
2,6-
dimethoxyphenol
FL/FR
dimethyl benzyl carbinol
FL/FR
musk
ethylene brassylate
FL/FR
dextro,laevo-
muscone
FL/FR
musty
2,3,5-
trimethyl pyrazine
FL/FR
naphthyl
2,4-
dimethyl benzaldehyde
FL/FR
para-
methyl anisole
FL/FR
nutty
2-
acetyl furan
FL/FR
prunus amygdalus amara seed extract
FL/FR
phenolic
methyl benzoate
FL/FR
powdery
ortho-
acetanisole
FL/FR
acetophenone
FL/FR
beta-
naphthyl ethyl ether
FL/FR
powdery ketone
FL
rummy
vanillyl ethyl ether
FL/FR
soapy
dodecanal (aldehyde C-12 lauric)
FL/FR
1-
dodecanol
FL/FR
spicy
allspice oil
FL/FR
para-
anisyl formate
FL/FR
benzyl cinnamate
FL/FR
benzyl isoeugenol
FL/FR
cassia bark oil china
FL/FR
cinnamon bark oil (cinnamomum zeylanicum) india
FL/FR
cinnamyl cinnamate
FL/FR
clove bud oil
FL/FR
elettaria cardamomum seed oil
FL/FR
iso
eugenyl acetate
FL/FR
2-
hydroxybenzaldehyde
FL/FR
ortho-
methoxycinnamaldehyde
FL/FR
alpha-
methyl cinnamaldehyde
FL/FR
methyl cinnamate
FL/FR
methyl isoeugenol
FL/FR
3-
phenyl propyl alcohol
FL/FR
chai
vanilla flavor
FL
sweet
cyclohexyl acetic acid
FL/FR
vanilla oleoresin bali
FL/FR
tropical
alpha-
amyl cinnamaldehyde
FL/FR
vanilla
vanilla
chai flavor
FL
ethyl vanillin
FL/FR
ethyl vanillin isobutyrate
FL/FR
ethyl vanillin propylene glycol acetal
FL/FR
4-
methyl guaiacol
FL/FR
omega-
pentadecalactone
FL/FR
vanilla bean absolute (vanilla planifolia)
FL/FR
vanillin
FL/FR
vanillyl acetate
FL/FR
vanillyl isobutyrate
FL/FR
waxy
decanal (aldehyde C-10)
FL/FR
decanol
FL/FR
decyl acetate
FL/FR
alpha-
hexyl cinnamaldehyde
FL/FR
hydroxycitronellal
FL/FR
rhodinyl phenyl acetate
FL/FR
woody
amyris wood oil
FL/FR
frankincense oil
FL/FR
guaiacwood oil
FL/FR
(E)-beta-
ionone
FL/FR
alpha-
irone
FL/FR
methyl ionyl acetate
FL/FR
patchouli oil
FL/FR
 
Potential Uses:
FRabronia
FRacacia
 aimant
FRaldehydic
FRamber
FRambrene
 amour-amour
 angel
FRapple blossom
 arpege
 arrack
FRbaby powder
FRbalsam
FRbanana
FRbayberry
FRblackberry
 bluebell
FRblueberry
FRbouquet
FRcarnation
FRcherry
FRcherry blossom
FRclover
FRcoconut
FRcoconut tropical coconut
FRcountry meadow
FRcrabapple blossom
FRcream
 decumaria
FRdillenia
FRfern
FRfetes
FRfir needle oil replacer
 fixer
FRfloral
 florida breeze
FRfresh and clean
FRgardenia
FRgenet
FRginger white ginger
FRgingerbread
FRhabuba
FRhawthorn
FRhay new mown hay
FRheliotrope
FRhoneysuckle
FRhop
 hugonia
FRhyacinth
 japan flowers
 je reviens
FRleather russian leather
FRlemon
FRlilac
FRlily
FRlily of the valley
FRlinden flower
FRlotus
FRmagnolia
FRmimosa
FRmint
 monimia
FRmusk
 my sin
FRnarcissus
 nemesia
FRneroli
FRophira
FRorchid
FRoriental
FRorris
FRpassion blossom
FRpatchouli
FRpeach
FRpina colada
FRpine forest
FLpistachio
FRpowder
FRpumpkin pie
FRrain
FRrose
FRsandalwood
 scandal
FRspice
FRsweet pea
 tide
FRtobacco
FRtonka bean
FRtuberose
FRvanilla
FRviolet
FRwallflower
FRwisteria
FRwoody
 
Occurrence (nature, food, other):note
 blueberry fruit
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 blueberry plant
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 camphor wood
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 chicken
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 dill
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 melon
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 pepper black pepper fruit
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 pepper black pepper oil
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 pepper black pepper seed
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 sherry
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 spirea ulmaria
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 tobacco burley tobacco
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 vanilla spp.
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 vanilla tahiti vanilla
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 violet flower
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Synonyms:
 benzo[1,3]dioxole-5-carbaldehyde
 benzo[d][1,3]dioxole-5-carbaldehyde
2H-benzo[d]1,3-dioxolene-5-carbaldehyde
1,3-benzodioxole-5-carbaldehyde
2H-1,3-benzodioxole-5-carbaldehyde
1,3-benzodioxole-5-carboxaldehyde
3,4-dihydroxybenzaldehyde methylene ketal
3,4-dimethylene dioxybenzaldehyde
 dioxymethylene procatechuic aldehyde
 dioxymethylene protocatechuic aldehyde
 formaldehyde protechualdehyde-3,4-cyclic acetal
5-formyl-1,3-benzodioxole
 geliotropin
 heliobase
 heliotropin natural
 heliotropin recrystallized extra FCC
 heliotropine
 heliotropine crystals
 heliotropine crystals FCC
 heliotropine natural
 heliotropine synthetic
3,4-methylene dioxy) benzaldehyde
3,4-bis(methylene dioxy) benzaldehyde
3,4-(methylene dioxy)-1,3-benzodioxole-5-benzaldehyde
3,4-methylene dioxybenzaldehyde
3,4-methylene protocatechuic aldehyde
3,4-(methylenedioxy)benzaldehyde
3,4-methylenedioxybenzaldehyde
 piperonal
 piperonal nat.
 piperonaldehyde
 piperonyl aldehyde
 piperonylaldehyde
 protocatechuic aldehyde methylene ether
 

Articles:

Google Patents:Process for preparing piperonal
PubMed:Can head louse repellents really work? Field studies of piperonal 2% spray.
J-Stage:First Total Synthesis of Justicidone, a p-Quinone-Lignan Derivative from Justicia hyssopifolia
PubMed:Piperonal prevents high-fat diet-induced hepatic steatosis and insulin resistance in mice via activation of adiponectin/AMPK pathway.
J-Stage:Synthesis of Optically Active Olivil Type of Lignan from L-Arabinose Using threo-Selective Aldol Condensation as a Key Reaction
PubMed:Forensic profiling of sassafras oils based on comprehensive two-dimensional gas chromatography.
PubMed:Anticancer activity and biophysical reactivity of copper complexes of 2-(benzo[d][1,3]dioxol-5-ylmethylene)-N-alkylhydrazinecarbothioamides.
PubMed:Enantiomeric HPLC resolution and absolute stereochemistry assignment of a new poligamain derivative.
PubMed:Production of natural fragrance aromatic acids by coexpression of trans-anethole oxygenase and p-anisaldehyde dehydrogenase genes of Pseudomonas putida JYR-1 in Escherichia coli.
PubMed:Synthesis and impurity profiling of MDMA prepared from commonly available starting materials.
PubMed:Synthesis and GC-MS analysis of a series of homologs and regioisomers of 3,4-methylenedioxypyrovalerone (MDPV).
PubMed:Piperonal ciprofloxacin hydrazone induces growth arrest and apoptosis of human hepatocarcinoma SMMC-7721 cells.
PubMed:Selective recognition of sesamol using molecularly imprinted polymers containing magnetic wollastonite.
PubMed:Simultaneous determination of bioactive compounds in Piper nigrum L. and a species comparison study using HPLC-PDA.
PubMed:Availability of target odor compounds from seized ecstasy tablets for canine detection.
PubMed:Half-sandwich ruthenium–arene complexes with thiosemicarbazones: synthesis and biological evaluation of [(η⁶-p-cymene)Ru(piperonal thiosemicarbazones)Cl]Cl complexes.
PubMed:Synthesis and characterization of mixed-ligand diimine-piperonal thiosemicarbazone complexes of ruthenium(II): Biophysical investigations and biological evaluation as anticancer and antibacterial agents.
PubMed:S-selective hydroxynitrile lyase from a plant Baliospermum montanum: molecular characterization of recombinant enzyme.
PubMed:Total synthesis of (+)-virgatusin via AlCl3-catalyzed [3+2] cycloaddition.
PubMed:In vitro biological studies and structural elucidation of fluoro-substituted phenyl acrylic acids.
PubMed:Enhancement in sample collection for the detection of MDMA using a novel planar SPME (PSPME) device coupled to ion mobility spectrometry (IMS).
PubMed:Toxicological methods for tracing drug abuse: chromatographic, spectroscopic and biological characterisation of ecstasy derivatives.
PubMed:Dynamic planar solid phase microextraction-ion mobility spectrometry for rapid field air sampling and analysis of illicit drugs and explosives.
PubMed:Detection of piperonal emitted from polymer controlled odor mimic permeation systems utilizing Canis familiaris and solid phase microextraction-ion mobility spectrometry.
PubMed:N-[(E)-1,3-Benzodioxol-5-yl-methyl-idene]-4-methyl-aniline.
PubMed:Titanium imido complexes utilizing orthometallated derivatized acetophenone and piperonal imine ligands: synthesis, isolation, and characterization.
PubMed:A combined experimental and theoretical study of the polar [3 + 2] cycloaddition of electrophilically activated carbonyl ylides with aldehydes and imines.
PubMed:Adsorbed resin phase spectrophotometric determination of vanillin or/and its derivatives.
PubMed:[Synthesis of pyridine-containing diacylhydrazones and study on their spectral properties].
PubMed:Design, synthesis, and biological evaluation of platensimycin analogues with varying degrees of molecular complexity.
PubMed:Headspace sampling and detection of cocaine, MDMA, and marijuana via volatile markers in the presence of potential interferences by solid phase microextraction-ion mobility spectrometry (SPME-IMS).
PubMed:Synthesis and use of 4-peptidylhydrazido-N-hexyl-1,8-naphthalimides as fluorogenic histochemical substrates for dipeptidyl peptidase IV and tripeptidyl peptidase I.
PubMed:Silenes in organic synthesis: a concise synthesis of (+/-) -epi-picropodophyllin.
PubMed:Electrochemical and spectroscopic characterisation of amphetamine-like drugs: application to the screening of 3,4-methylenedioxymethamphetamine (MDMA) and its synthetic precursors.
PubMed:Alpha-phenyl-N-tert-butyl nitrone (PBN) derivatives: synthesis and protective action against microvascular damages induced by ischemia/reperfusion.
PubMed:Development and validation of an RP-HPLC method for quantitative determination of vanillin and related phenolic compounds in Vanilla planifolia.
PubMed:The fumigant and repellent activity of aliphatic lactones against Pediculus humanus capitis (Anoplura: Pediculidae).
PubMed:Synthesis of 7-deoxypancratistatin from carbohydrates by the use of olefin metathesis.
PubMed:A study of impurities in intermediates and 3,4-methylenedioxymethamphetamine (MDMA) samples produced via reductive amination routes.
PubMed:First total synthesis of justicidone, a p-quinone-lignan derivative from Justicia hyssopifolia.
PubMed:Determination of synthesis method of ecstasy based on the basic impurities.
PubMed:Chemical profiling of 3,4-methylenedioxymethamphetamine (MDMA) tablets seized in Hong Kong.
PubMed:[Succivil efficacy in endogenous intoxication].
PubMed:[Study on the spectrophotometric determination of vanadium with piperonal fluorone by atomic absorption spectrophotometer].
PubMed:[Study on the determination of iron by silica gel H phase-diffuse reflectance spectrometry].
PubMed:Bhc-diol as a photolabile protecting group for aldehydes and ketones.
PubMed:Microbiologic oxidation of isosafrole into piperonal.
PubMed:Concentrations of nine alkenylbenzenes, coumarin, piperonal and pulegone in Indian bidi cigarette tobacco.
PubMed:[Comparative evaluation of antioxidant properties of neoselen and berberin in chronic heliotrinal hepatitis].
PubMed:[Morphological features of the thymus in heliotrin hepatitis upon administration of immunostimulators].
PubMed:A short synthesis of (+/-)-epiasarinin.
PubMed:Antioxidant properties of 8.0.4'-neolignans.
PubMed:Asymmetric Synthesis of Sesaminone: Confirmation of Its Structure and Determination of Its Absolute Configuration.
PubMed:Synthesis of optically active olivil type of lignan from L-arabinose using threo-selective aldol condensation as a key reaction.
PubMed:Histochemical method for dipeptidyl aminopeptidase II with a new anthraquinonyl hydrazide substrate.
PubMed:[The effect of perftoran on the biochemical detoxication parameters in rats with an acute toxic lesion of the liver].
PubMed:Enzyme-assisted asymmetric total synthesis of (-)-podophyllotoxin and (-)-picropodophyllin.
PubMed:Quantitation of flavor-related alkenylbenzenes in tobacco smoke particulate by selected ion monitoring gas chromatography-mass spectrometry.
PubMed:[The effect of immunomudulin on the structural-functional status of the organs of the immune and hematopoietic systems in chronic toxic hepatitis].
PubMed:Solid phase microextraction of alkenylbenzenes and other flavor-related compounds from tobacco for analysis by selected ion monitoring gas chromatography-mass spectrometry.
PubMed:Specificity and sensitivity of a human olfactory receptor functionally expressed in human embryonic kidney 293 cells and Xenopus Laevis oocytes.
PubMed:Cloning, functional expression and characterization of a human olfactory receptor.
PubMed:An Asymmetric Synthesis of L-694,458, a Human Leukocyte Elastase Inhibitor, via Novel Enzyme Resolution of beta-Lactam Esters.
PubMed:Antimutagenic and anticarcinogenic activity of natural and synthetic curcuminoids.
PubMed:Synthesis, anti-GABA activity and preferred conformation of bicuculline and norbicuculline enantiomers.
PubMed:Fragrance administration to reduce anxiety during MR imaging.
PubMed:Head louse repellents.
PubMed:Arena tests with piperonal, a new louse repellent.
PubMed:New head louse repellent.
PubMed:[Contamination in illegal amphetamine. Contaminants resulting from the synthesis of 3,4-(methylenedioxy)amphetamine (MDA) via condensation between nitroethane and piperonal].
PubMed:[Synthesis of derivatives of 2,4-bis(arylmethino)-8-butyl-8- azabicyclo[3.2.1]octan-3-one].
PubMed:Determination of coumarin as an adulterant in vanilla flavoring products by high-performance liquid chromatography.
PubMed:Metabolic disposition of piperine in the rat.
PubMed:Inhibition of rabbit nasal and hepatic cytochrome P-450-dependent hexamethylphosphoramide (HMPA) N-demethylase by methylenedioxyphenyl compounds.
PubMed:Chemosensitivity of lobster,Homarus americanus, to secondary plant compounds: Unused receptor capabilities.
PubMed:Metabolism of piperonal and piperonyl alcohol in the rat with special reference to the scission of the methylenedioxy group.
PubMed:The inhibition of rat nasal cytochrome P-450-dependent mono-oxygenase by the essence heliotropin (piperonal).
PubMed:Genotoxicity of safrole-related chemicals in microbial test systems.
PubMed:The metabolism of some food additives related to piperonal in the rabbit.
PubMed:Quantitative determination of chlorpromazine. HCl in tablets, spansules, injectables, and bulk chemical by nuclear magnetic resonance spectroscopy.
PubMed:[The mechanism of centrolobular hepatic necrosis in acute heliotropin poisoning].
PubMed:[Changes in the antigenic composition of the rat liver in acute and chronic heliotropin poisoning].
PubMed:[AUTOANTIGENICITY IN EXPERIMENTAL LIVER DISEASES (ANTIGENIC PROPERTIES OFTHE SERUM IN HELIOTROPIN-INDUCED HEPATITIS)].
PubMed:Correlation of piperonal test values for aromatic compounds with the atmospheric concentration of benzo(A)pyrene.
PubMed:[ON THE SYNTHESIS OF PIPERONAL].
 
Notes:
Blend with 7 parts anisyl alcohol and 5 parts heliotropin to remove the custard note. Imparts a lasting sweetness whenever used. sandalwood enhancer - santall and heliotropin. has been used as a pediculicide. Flavouring agent used in cherry and vanilla flavours
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