Blend with 7 parts anisyl alcohol and 5 parts heliotropin to remove the custard note. Imparts a lasting sweetness whenever used. sandalwood enhancer - santall and heliotropin. has been used as a pediculicide.
  • Advanced Biotech
  • Alfrebro
    • Alfrebro LLC
      Let's get reacquainted
      Building great taste with aroma chemicals, extracts, and distillates
      The Alfrebro brand was established in the early 1900s by Alex Fries & Brothers, a Cincinnati Flavor Company. In 1980, the brand was re-launched as an aroma chemical manufacturer. Since its inception, Alfrebro’s primary focus has been to provide quality natural and high value synthetic chemicals.
      Email: Sarah Forbis
      Email: Sales
      Voice: 513-539-3021
      Fax: 513-539-7372
      US Voice: 513-539-7373
      Heliotropin, Natural
  • Axxence Aromatic
    • Axxence Aromatic GmbH
      We bring nature to your flavour
      Dedicated to provide the best possible quality and supply service of natural aroma ingredients.
      Axxence Aromatic is entirely dedicated to provide the best possible quality and supply service of natural aroma ingredients to the Flavour & Fragrance Industry worldwide.
      Email: Service
      Voice: +49.2822.68561.0
      Fax: +49.2822.68561.39
      Products List: View
      291100 HELIOTROPIN Natural Kosher
  • Berjé
    • Berjé Inc.
      The solution is clear
      Where the world comes to its senses - Berjé is a global distributor of Essential Oils and Aromatic Chemicals.
      Berjé is a family-owned business that has been in operation for six decades. The company's origins and strength lie in a profound understanding of the supply and the quality of the diverse raw materials consumed by the flavor and fragrance industries. This base was expanded upon more than two decades ago to include fragrance production. The company's unparalleled raw material expertise is focused on the supply of essential oils and aromatic chemicals. This is supported by our long-standing relationships with a worldwide fabric of producers ensuring the greatest prospects for uninterrupted supply in markets that are often volatile and unpredictable.
      Email: For Information
      Email: For Sales
      Voice: 973-748-8980
      Fax: 973-680-9618
      Market Report
  • Bontoux
    • Bontoux S.A
      Major international supplier
      Major international Producer of aromatic ingredients for the production of fragrances, flavors, cosmetics, pharmaceuticals and Aromathopy.
      Bontoux Inc. was established in 1993 to directly service our North American clientele. The facility primarily serves as a Sales Customer Service, Repacking and Distribution Center for our customers in North America.
      Email: Information
      US Email: Information
      Email: Sales
      US Email: Sales
      Voice: + 33.(0)
      Fax: + 33.(0)
      US Voice: + 1.908.755.4800
      US Fax: + 1.908.755.4844
  • Charkit Chemical
    • Charkit Chemical Corporation
      The Specialty Chemical Specialists
      Explore this website to discover the products and services that Charkit provides for your industry and please contact us directly to find out how we can be of service to you.
      Since 1982, Charkit has been committed to expanding the markets we serve and our roster of products and services continues to grow with us. Personal care ingredients now include a substantial array of luxury and exotic components. Substantial inroads have been made in the nutraceutical and resins markets, with a growing roster of versatile and unique ingredients. And we continue to lead the way in our traditional markets such as Metal and Water Treatment, Imaging, Flavor & Fragrance, Aroma and Food. Our Pharmaceutical offerings continue to expand, still anchored by the Boronic Derivatives that meet the demands of Suzuki coupling reactions.
      Email: Sales
      Voice: 203-299-3220
      Fax: 203-299-1355
      Products List: View
  • Excellentia International
    • Excellentia International
      Ingredients by Nature
      Exceptional quality and excellence in meeting our customers requirements.
      Excellentia International was founded in 2010 through the merger of Excellentia Flavors LLC and Polarome International. Collectively, these companies account for more than one hundred years of industry experience, and are recognized for exceptional quality and excellence in meeting our customers’ requirements.
      Email: Info
      Email: Sales
      Email: Regulatory
      Voice: 732.749.9840
      Our Services
      Heliotropin Natural
  • Fleurchem
    • Fleurchem, Inc.
      Have A Flavorful Day
      A leading global manufacturer and supplier of ingredients for Flavors, Fragrances, AromaTherapy, Foods, Beverages, Personal Care Products, and other uses.
      Operating out of the 200,000 sq. ft., former Hercules/PFW facility in Middletown, NY; Fleurchem produces a full range of natural isolates, synthetic chemicals & specialities, essential oils and flavors. Additionally, the company performs toll manufacturing, as well as custom chemical synthesis for a wide range of clients.
      Email: Information
      US Voice: 845-341-2100
      US Fax: 845-341-2121
      heliotropin natural
  • Indukern F&F
  • Lansdowne Chemicals
    • Lansdowne Chemicals
      With a focus on providing the highest level of service
      Lansdowne Chemicals has established itself at the forefront of the global chemical industry.
      Headquarters are in Carterton, Oxfordshire encompassing all of Lansdowne's Business Units. Our Regulatory Team and Quality Control Departments are based out of Carterton. Lansdowne Aromatic's state of the art warehouse facilities are located in Cricklade, covering 12,000 square ft. We are able to offer just-in-time deliveries for our full range of products, in a variety of pack sizes. Bonded facilities are available for goods going outside of the EU.
      Email: Contact Us:
      US Email: Dean Matienzo - Sales Manager
      Voice: +44 1993 843081
      Fax: +44 1993 841261
      US Voice: +1 973 886 3778
      US Fax: +1 973 346 1106
      Whats New
      Global Distribution
  • Lluch Essence
    • Lluch Essence S.L.
      A family company dedicated to sales and distribution
      Flexibility, availability, price and quality.
      Flexibility, availability, price and quality make LLUCH ESSENCE S.L. one of Europe’s references when it comes to essential oils and aroma chemicals, and it is now well known all around the world.
      Email: Info
      Voice: 34 93 379 38 49
      Fax: 34 93 370 65 04
  • M&U International
    • M&U International LLC
      Steady supply & demand
      Meeting customers increasing demands at home as well as abroad.
      M&U dedicates itself to the development and production of new products as well as continuously promoting those new products. We’ve maintained a steady supply&demand relationship with a large number of manufacturers at home and abroad. We’ve developed an extensive network and because of our relationships with these manufacturers, we’re able to provide a stable supply of great quality materials. We’re located in China’s largest communications hub, Shanghai and in the U.S. near one of the largest sea ports on the East Coast. The strategic locations of our facilities ensure convenient, prompt and secure delivery of our products to our customers. We warmly welcome your inquiries, come witness our solemn commitment for yourself.
      Email: Sales
      US Email: Sales
      Voice: +86-21-32515501 60762991 60762992
      Fax: +86-21-32515502 64204960
      US Voice: 908-359-9000
      US Fax: 908-359-9002
  • PCW France
    • PCW France
      Your partner in Fragrances since 1986
      Our mission is to convey an emotion through perfumery.
      PCW founded in 1986, is based in new world-class facilities in the town of Grasse, France. The company aims at supplying the main materials used in perfumery, directly sourcing from important manufacturers worldwide. More than 1000 high-quality references can be provided all over the world with 48 hours dispatch. There is no minimum order line, feel free to contact us for any enquiry.
      Email: Sales team
      Email: Sales team
      Email: Mrs Eleonore Thore :
      Email: Mrs Jennie Brugnot :
      Voice: +33 (0)4 92 28 23 30
      Fax: +33 (0)4 92 28 23 39
      Steps to a fragranced product
      Products List: View
  • Penta International
    • Penta International Corporation
      Chemistry innovation
      At Penta, our products and services help businesses do business better.
      For over 30 years, Penta Manufacturing Company has played a growing role in worldwide chemistry innovations and applications. As an industry leader, Penta continues to pioneer chemistry-based solutions for practically every area of commerce. Our products and expertise have helped fuel technical advances in dozens of commercial applications including flavoring, coloring, fragrances and chemical processes.
      US Email: Technical Services
      US Email: Sales
      US Voice: (973) 740-2300
      US Fax: (973) 740-1839
      08-03600 HELIOTROPIN, Kosher
      08-03601 HELIOTROPIN, NATURAL, Kosher
  • Phoenix Aromas & Essential Oils
    • Phoenix Aromas & Essential Oils, Inc.
      EXCEPTIONAL Flavor and Fragrance Ingredients.
      Phoenix sources the finest flavor and fragrance ingredients for its customers.
      Phoenix Aromas & Essential Oils LLC was founded in 1994, grounded in a simple set of core values: provide top-quality products, cost-effective pricing and personalized attention to all our customers. After two decades, we remain committed to those values. With extensive market knowledge of our products, we anticipate, as opposed to merely react, to industry challenges. You can rely on us for all your flavor and fragrance ingredient needs. Customers benefit from Phoenix's long-standing relationships with experienced and reputable growers, processors and manufacturers in key global locations, who are committed to sustainability and green programs. With a strategically located 80,000 sq-ft facility, customers can rely on Phoenix to deliver quality products on time, and cost-effectively.
      Email: EU Info
      US Email: Info
      US Email: Sales
      Voice: +44(0) 208 532 1022
      Fax: +44(0) 208 532 1023
      US Voice: 201-784-6100
      US Fax: 201-784-8566
      Global Reach
      Heliotropine Natural
  • Sigma-Aldrich
    • Sigma-Aldrich
      Complete Supply Chain
      The perfect blend of products and services that bring your creativity to life.
      Sigma-Aldrich is a leading Life Science and High Technology company dedicated to providing high-quality, safe and certified flavor ingredients with transparent and easily accessible documentation to customers around the globe. Sigma-Aldrich also provides a suite of analytical tools that allow food analysts to simplify sample preparation, cleanup and analysis steps, while increasing sensitivity to trace ingredients and harmful substances to meet regulations and quality standards.
      Email: Information
      US Email: Sales
      US Voice: 800-244-1173
      US Fax: 800-368-4661
      Certified Food Grade Products
      W291102 Piperonal, ≥99%, FCC, FG
      W291113 Piperonal, natural, 98%, FG
  • SRS Aromatics
    • SRS Aromatics Ltd
      For over 25 years
      Bringing flavour and fragrance into your world.
      As suppliers / distributors of ingredients to the fragrance and flavour industries, our goal is to provide high quality materials at competitive prices with an exceptional level of service. Established in 1984, SRS Aromatics Ltd is an independent family owned business which has become very well-respected within the fragrance and flavour industry as a reliable and trustworthy partner. Over the years this has allowed the company to develop strong relationships with many global manufacturers; several of whom we represent in the UK. A core aim of our business is to work extremely closely with both our suppliers and customers to maximise service levels with minimum disruption to supply.
      Email: Info
      Email: Sales
      Voice: +44 (0) 1284 704076
      Fax: +44 (0) 1284 760819
  • The John D. Walsh Company
    • The John D. Walsh Company, Inc
      Suppliers Since 1942
      Supplying the fragrance and flavor industry with high quality products.
      The John D. Walsh Company, Inc. has evolved from its beginnings as an agent/broker into a distributor of essential oils, aroma chemicals, concretes and absolutes. We currently represent the following companies, as their North American distributor: Destilerias Munoz Galvez, S.A. International Flavors & Fragrances PFW Aroma Chemicals B.V. Innospec Widnes Limited Hydrodiffusion de Guatemala, S. A. DSM Nutritional Products The John D. Walsh Company, Inc. is proud to be a founding member of IFEAT, an active member of IFRA, North America, and a corporate sponsor of the WFFC.
      Email: Information
      Email: Sales
      Email: Firmenich Flavor inquiries
      Voice: 973-962-1400
      Fax: 973-962-1557
      Firmenich Flavor Phone:973-962-1888
      Firmenich Flavor Fax:973-962-1898
  • Treatt
    • Treatt PLC
      Innovative ingredient solutions
      World-leading innovative ingredient solutions provider for the flavour, fragrance and FMCG industries.
      We offer innovative and trend-setting product concepts for our customers, collaborating with them to create true value for their products.
      Email: Enquiries
      US Email: Enquiries
      Voice: +44 (0) 1284 702500
      Fax: +44 (0) 1284 703809
      US Voice: +1 863 668 9500
      US Fax: +1 863 668 3388
  • Ernesto Ventós
Synonyms   Articles   Notes   Search
Fragrance Demo Formulas    Flavor Demo Formulas
1,3-benzodioxole-5-carbaldehyde (Click)
CAS Number: 120-57-0 30024-74-9
ECHA EINECS - REACH Pre-Reg: 204-409-7
Nikkaji Web: J2.919J
Beilstein Number: 131691
MDL: MFCD00005828
CoE Number: 104
XlogP3: 1.10 (est)
Molecular Weight: 150.13342000
Formula: C8 H6 O3
BioActivity Summary: listing
NMR Predictor: Predict
EFSA/JECFA Comments: ADI: 0-2.5 (JECFA, 1968).
Category: cosmetic, flavor and fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist: Search
Google Patents: Search
US Patents: Search
EU Patents: Search
IBM Patents: Obtain
Pubchem Patents: Search
PubMed: Search
NCBI: Search
JECFA Food Flavoring: 896  piperonal
Flavis Number: 05.016 (Old)
DG SANTE Food Flavourings: 05.016  piperonal
FEMA Number: 2911  piperonal
FDA Regulation:
Subpart A--General Provisions
Sec. 182.60 Synthetic flavoring substances and adjuvants.
Synonyms   Articles   Notes   Search   Top
Physical Properties:
Appearance: white crystalline powder (est)
Assay: 98.00 to 100.00 % 
Heavey Metals: <40.00 ppm
Food Chemicals Codex Listed: Yes
Melting Point: 37.00 to  39.00 °C. @ 760.00 mm Hg
Boiling Point: 263.00 to  265.00 °C. @ 760.00 mm Hg
Boiling Point: 144.00 to  145.00 °C. @ 15.00 mm Hg
Congealing Point: 35.30 °C.
Acid Value: 3.00 max. KOH/g
Vapor Pressure: 0.003000 mm/Hg @ 25.00 °C.
Flash Point: > 230.00 °F. TCC ( > 110.00 °C. )
logP (o/w): 1.050
Shelf Life: 24.00 month(s) or longer if stored properly.
Storage: store in cool, dry place in tightly sealed containers, protected from heat and light.
Synonyms   Articles   Notes   Search   Top
Organoleptic Properties:
Odor Type: floral
Odor Strength: medium
 heliotrope  sweet  powdery  coconut  vanilla  
Odor Description:
at 100.00 %. 
heliotrope flower sweet powdery coconut vanilla
Luebke, William tgsc, (1982)
 cherry  vanilla  sweet  cherry maraschino cherry  creamy  cinnamyl  
Odor Description:
Cherry, vanilla, sweet cherry pit notes and creamy with cinnamic nuances
Mosciano, Gerard P&F 21, No. 5, 49, (1996)
 cherry maraschino cherry  cherry  vanilla  spicy  
Taste Description:
at 15.00 ppm.  
Benzaldehyde, cherry, vanilla and spicy
Mosciano, Gerard P&F 21, No. 5, 49, (1996)
Substantivity: 212 Hour(s)
Synonyms   Articles   Notes   Search   Top
Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: masking agents
perfuming agents
skin conditioning
Synonyms   Articles   Notes   Search   Top
Advanced Biotech
98% min.
Advanced Biotech
Heliotropin, Natural
Odor: Heliotrope Flower Sweet Coconut
Axxence Aromatic
Bell Flavors & Fragrances
Bell Flavors & Fragrances
Natural Heliotropine (EU)
Bell Flavors & Fragrances
Natural Heliotropine
Charkit Chemical
Citrus and Allied Essences
Heliotropin Recrystallized Extra FCC
Market Report
De Monchy Aromatics
Ernesto Ventós
Excellentia International
Heliotropin Natural
heliotropin natural
Frinton Laboratories
For experimental / research use only.
Global Essence
Indenta Group
Indukern F&F
Lansdowne Chemicals
Lluch Essence
Lluch Essence
M&U International
M&U International
Odor: sweet, vanilla
Flavor: sweet, aromatic, vanilla, benzaldehyde
Odor: sweet, vanilla
Flavor: sweet, aromatic, vanilla, benzaldehyde
PCW France
Steps to a fragranced product
Penta International
Penta International
Perfumer Supply House
Heliotropin Crystals (Piperonal) – for a limited time only
Phoenix Aromas & Essential Oils
Heliotropine Natural
Phoenix Aromas & Essential Oils
Reincke & Fichtner
Heliotropin natural
Reincke & Fichtner
Piperonal, ≥99%, FCC, FG
Odor: almond; anise; balsam; berry; cherry; creamy; floral; raspberry; sweet; vanilla; violet; woody; wine-like; herbaceous
Certified Food Grade Products
Piperonal, natural, 98%, FG
Odor: floral
SRS Aromatics
99% as Piperonal
Odor: Cherry-like
Use: Widely used in perfumery. Used in powdery accords, but also in florals, like muguet, carnation, and lilac. Give softness and creaminess.
The Fragrance Museum
The John D. Walsh Company
Vigon International
Heliotropine Crystals Synthetic ex Sassafras
Vigon International
Heliotropine Crystals
Vigon International
Heliotropine Natural
WEN International
Synonyms   Articles   Notes   Search   Top
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
Xi - Irritant
R 36/37/38 - Irritating to eyes, respiratory system, and skin.
S 02 - Keep out of the reach of children.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36 - Wear suitable protective clothing.
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
Skin irritation (Category 2), H315
Acute aquatic toxicity (Category 3), H402
Chronic aquatic toxicity (Category 3), H412
GHS Label elements, including precautionary statements
Signal word Warning
Hazard statement(s)
H315 - Causes skin irritation
H402 - Harmful to aquatic life
H412 - Harmful to aquatic life with long lasting effects
Precautionary statement(s)
P264 - Wash skin thouroughly after handling.
P273 - Avoid release to the environment.
P280 - Wear protective gloves/protective clothing/eye protection/face protection.
P302 + P352 - IF ON SKIN: wash with plenty of soap and water.
P332 + P313 - IF SKIN irritation occurs: Get medical advice/attention.
P362 - Take off contaminated clothing and wash before reuse.
P501 - Dispose of contents/ container to an approved waste disposal plant.
Human Experience:
6 % solution: no irritation or sensitization.
Oral/Parenteral Toxicity:
gavage-rat LD50  [sex: M,F] 2700 mg/kg
(Jenner et al., 1964)

gavage-rat LD50  [sex: M,F] 2700 mg/kg
(Taylor et al., 1964)

gavage-rat LD50  [sex: M,F] 2700 mg/kg
(Hagan et al., 1965)

intraperitoneal-mouse LD50  480 mg/kg
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 43, Pg. 370, 1954.

oral-rat LD50  2700 mg/kg
Toxicology and Applied Pharmacology. Vol. 6, Pg. 378, 1964.

intraperitoneal-rat LDLo  1500 mg/kg
Revue Medicale de la Suisse Romande. Vol. 16, Pg. 449, 1896.

Dermal Toxicity:
skin-rabbit LD50 > 5000 mg/kg
National Technical Information Service. Vol. OTS0535062

skin-rat LD50 > 5 mg/kg
National Technical Information Service. Vol. OTS0535062

Inhalation Toxicity:
Not determined
Synonyms   Articles   Notes   Search   Top
Safety in Use Information:
Category: cosmetic, flavor and fragrance agents
Recommendation for heliotropin usage levels up to:
  8.0000 % in the fragrance concentrate.
Maximised Survey-derived Daily Intakes (MSDI-EU): 1500.00 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 3200.00 (μg/capita/day)
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
Click here to view publication 3
 average usual ppmaverage maximum ppm
baked goods: -18.00000
beverages(nonalcoholic): -6.00000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: -36.00000
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: -7.00000
fruit ices: -7.00000
gelatins / puddings: -5.80000
granulated sugar: --
gravies: --
hard candy: -7.40000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --
Synonyms   Articles   Notes   Search   Top
Safety References:
Flavor & Extract Manufacturers Association (FEMA) reference(s):
The FEMA GRAS assessment of hydroxyl- and alkoxy-substituted benzyl derivatives used as flavor ingredients.View pdf
European Food Safety Athority(efsa): Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...
European Food Safety Authority (EFSA) reference(s):
Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the Commission related to Flavouring Group Evaluation 20 (FGE.20): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical group 23
View page or View pdf
Flavouring Group Evaluation 52 (FGE.52): Consideration of hydroxy- and alkoxy-substituted benzyl derivatives evaluated by JECFA (57th meeting) structurally related to benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters evaluated by EFSA in FGE.20 (2005) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf
Flavouring Group Evaluation 54 (FGE.54)[1] - Consideration of benzyl derivatives evaluated by JECFA (57th meeting) structurally related to benzyl alcohols, benzaldehydes, a related acetal, benzoic acids and related esters evaluated by EFSA in FGE.20 (2005) - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food
View page or View pdf
Flavouring Group Evaluation 20, Revision 1 (FGE.20Rev1): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids and related esters from chemical group 23
View page or View pdf
Flavouring Group Evaluation 54, Revision 1 (FGE.54Rev1): Consideration of benzyl derivatives evaluated by JECFA (57th meeting) structurally related to benzyl alcohols, benzaldehydes, a related acetal, benzoic acids and related esters evaluated by EFSA in FGE.20Rev1 (2009)
View page or View pdf
Scientific Opinion on Flavouring Group Evaluation 20, Revision 2 (FGE.20Rev2): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical groups 23 and 30
View page or View pdf
Scientific Opinion on Flavouring Group Evaluation 20, Revision 3(FGE.20Rev3): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical groups 23 and 30
View page or View pdf
EPI System: View
NLM Hazardous Substances Data Bank: Search
Chemical Carcinogenesis Research Information System: Search
Cancer Citations: Search
Toxicology Citations: Search
Env. Mutagen Info. Center: Search
EPA Substance Registry Services (TSCA): 120-57-0
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 8438
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 2
Chemidplus: 0000120570
EPA/NOAA CAMEO: hazardous materials
RTECS: TO1575000 for cas# 120-57-0
Synonyms   Articles   Notes   Search   Top
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 120-57-0
Pubchem (cid): 8438
Pubchem (sid): 134975051
Pherobase: View
Synonyms   Articles   Notes   Search   Top
Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS): View
KEGG (GenomeNet): C10812
HMDB (The Human Metabolome Database): HMDB32612
YMDB (Yeast Metabolome Database): YMDB01776
Export Tariff Code: 2932.93.0000
Haz-Map: View
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
Read: Under the conditions of intended use - New developments in the FEMA GRAS program and the safety assessment of flavor ingredients
Read: A GRAS assessment program for flavor ingredients
Read: Sensory testing for flavorings with modifying properties. Food Technology
Read: Criteria for the safety evaluation of flavoring substances
Read: A procedure for the safety evaluation of natural flavor complexes used as ingredients in food: essential oils
Read: FEMA Expert Panel: 30 Years of safety evaluation for the flavor industry
Read: Consumption ratio and food predominance of flavoring materials
grades: technical; fcc
Synonyms   Articles   Notes   Search   Top
Potential Blenders and core components note
2-acetyl furanFL/FR
 acetyl methyl anthranilateFL/FR
 allspice oilFL/FR
 amber formateFR
 ambrette seed oilFL/FR
isoamyl benzoateFL/FR
alpha-amyl cinnamaldehydeFL/FR
 amyl isoeugenolFR
isoamyl phenyl acetateFL/FR
isoamyl salicylateFL/FR
 amyris wood oilFL/FR
 animal carbolactoneFR
para-anisaldehyde / methyl anthranilate schiff's baseFR
 anise seed oil colombiaFL/FR
para-anisyl acetateFL/FR
para-anisyl alcoholFL/FR
 anisyl propanal / methyl anthranilate schiff's baseFR
 anthocephalus cadamba oilFR
 beeswax absoluteFL/FR
siam benzoin resinoidFL/FR
 benzyl acetateFL/FR
 benzyl alcoholFL/FR
 benzyl cinnamateFL/FR
 benzyl isoeugenolFL/FR
 benzyl salicylateFL/FR
 bergamot oilFL/FR
blood orange oil italyFL/FR
isobutyl benzoateFL/FR
isobutyl cinnamateFL/FR
 caramel furanoneFL
 elettaria cardamomum seed oilFL/FR
 cassia bark oil chinaFL/FR
 cherry oxyacetateFL/FR
 cinnamyl alcoholFL/FR
 clary sage oil franceFL/FR
 clove bud oilFL/FR
 clover nitrileFR
 cocoa butenalFL/FR
 cocoa oleoresinFL/FR
 cocoa pentenalFL/FR
 copaiba balsam oilFL/FR
 costus valerolactoneFR
para-cresyl propionaldehydeCS
 cyclohexyl acetic acidFL/FR
 cyclohexyl ethyl alcoholFL/FR
 decanal (aldehyde C-10)FL/FR
 decyl acetateFL/FR
 deertongue absoluteFR
 dimethyl alpha-iononeFR
 dimethyl anthranilateFL/FR
 dimethyl benzyl carbinolFL/FR
 dimethyl benzyl carbinyl butyrateFL/FR
ortho-dimethyl hydroquinoneFL/FR
 dodecanal (aldehyde C-12 lauric)FL/FR
 ethyl cinnamateFL/FR
 ethyl maltolFL/FR
 ethyl methyl-para-tolyl glycidateFL/FR
 ethyl phenyl acetateFL/FR
 ethyl vanillinFL/FR
 ethyl vanillin isobutyrateFL/FR
 ethyl vanillin propylene glycol acetalFL/FR
 ethylene brassylateFL/FR
isoeugenyl acetateFL/FR
 fir balsam absoluteFR
 floral pyranolFR
 frankincense oilFL/FR
(E)-geranyl acetoneFL/FR
 geranyl phenyl acetateFL/FR
 guaiacwood oilFL/FR
 gurjun balsam oilFR
 hay absoluteFR
 heliotrope absoluteFR
 heliotropyl acetateFL/FR
 heliotropyl acetoneFL/FR
 heliotropyl alcoholFL/FR
 heliotropyl diethyl acetalFR
(Z)-3-hexen-1-yl acetateFL/FR
(Z)-3-hexen-1-yl butyrateFL/FR
(Z)-3-hexen-1-yl propionateFL/FR
alpha-hexyl cinnamaldehydeFL/FR
 hexyl isovalerateFL/FR
 hyacinth etherFR
 immortelle absoluteFL/FR
 cistus ladaniferus resinoidFR
 lavender absolute bulgariaFL/FR
 linalool oxideFL/FR
para-methyl acetophenoneFL/FR
para-methyl anisoleFL/FR
alpha-methyl cinnamaldehydeFL/FR
 methyl cinnamateFL/FR
6-methyl coumarinFL
 methyl dihydrojasmonateFL/FR
para-methyl hydratropaldehydeFL/FR
alpha-methyl iononeFL/FR
beta-isomethyl iononeFL/FR
alpha-isomethyl ionone (50% min.)FL/FR
alpha-isomethyl ionone (90% min.)FL/FR
 methyl ionyl acetateFL/FR
 methyl isoeugenolFL/FR
 mint lactoneFL/FR
 exaltone (Firmenich)FR
 musk amberolFR
 musk indaneFR
 musk tetralinFR
 myrrh oilFL/FR
beta-naphthyl ethyl etherFL/FR
 neroli oil bigardeFL/FR
gamma-nonalactone (aldehyde C-18 (so-called))FL/FR
 orris pyridine 25% IPMFR
 orris rhizome resinoid (iris pallida)FL/FR
 patchouli ethanoneFR
 patchouli oilFL/FR
 peach pivalateFR
 peony alcoholFR
 peru balsam oilFL/FR
 phenethyl alcoholFL/FR
 phenethyl phenyl acetateFL/FR
 phenoxyethyl isobutyrateFL/FR
 phenyl acetic acidFL/FR
3-phenyl propionaldehydeFL/FR
3-phenyl propyl alcoholFL/FR
 powdery ketoneFL
 prenyl acetateFL/FR
isopropyl phenyl acetateFL/FR
 raspberry ketoneFL/FR
 rhodinyl phenyl acetateFL/FR
 rose absolute (rosa damascena) bulgariaFL/FR
 rose butanoateFL/FR
(+)-alpha-santalyl acetateFL/FR
 strawberry furanoneFL/FR
 timber propanolFR
 tobacarol (IFF)FR
 tolu balsamFL/FR
 tolualdehydes (mixed o,m,p)FL/FR
 tonka bean absoluteFR
2,3,5-trimethyl pyrazineFL/FR
 tuberose absolute (from pommade)FL/FR
gamma-undecalactone (aldehyde C-14 (so-called))FL/FR
10-undecenal (aldehyde C-11 undecylenic)FL/FR
10-undecen-1-yl acetateFL/FR
 vanilla bean absolute (vanilla planifolia)FL/FR
 vanilla oleoresin baliFL/FR
para-vanillic acidFL/FR
 vanillyl acetateFL/FR
para-vanillyl alcoholFL/FR
 vanillyl isobutyrateFL/FR
 vanillylidene acetoneFL/FR
 veramoss (IFF)FR
 vetiveryl acetateFL/FR
 watermelon ketoneFR
 woody acetateFR
(Z)-woody amyleneFR
 woody epoxideFR
 woody propanolFR
Synonyms   Articles   Notes   Search   Top
Potential Uses:
 acacia cassie farnesianaFR
 apple blossomFR
 baby powderFR
 carnation dianthus oeilletFR
 cherry blossomFR
 clover trefle le'trefle incarnatFR
 coconut tropicalFR
 crabapple blossomFR
 fern fougereFR
 fir needle pine needleFL/FR
 florida breeze 
 forest pine forestFR
 fresh & cleanFR
 genet genista broomFR
 ginger whiteFR
 hay new mown hay foin coupeFR
 honeysuckle chevrefeuilleFR
 hops houblonFL/FR
 hyacinth jacintheFR
 japan flowers 
 je reviens 
 leather russianFR
 lilac lilas syringaFR
 linden blossom limeflower tilleulFR
 meadow countryFR
 muguet lily of the valleyFR
 my sin 
 narcissus narcisseFR
 nut pistachioFL
 orris irisFR
 passion blossomFR
 pina coladaFR
 pumpkin pieFR
 sweet peaFR
 tonka beanFR
 wisteria wistaria glycineFR
Synonyms   Articles   Notes   Search   Top
Natural Occurrence in: note
 camphor wood
GRIN Trop Picture
 pepper black pepper
GRIN Trop Picture
 spirea ulmaria
GRIN Trop Picture
 tobacco burley tobacco
GRIN Trop Picture
 vanilla tahiti vanilla
GRIN Trop Picture
 violet flower
GRIN Trop Picture
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3,4-dihydroxybenzaldehyde methylene ketal
3,4-dimethylene dioxybenzaldehyde
 dioxymethylene procatechuic aldehyde
 dioxymethylene protocatechuic aldehyde
 formaldehyde protechualdehyde-3,4-cyclic acetal
 heliotropin natural
 heliotropin recrystallized extra FCC
 heliotropine crystals
 heliotropine crystals FCC
 heliotropine natural
 heliotropine synthetic
3,4-methylene dioxy) benzaldehyde
3,4-bis(methylene dioxy) benzaldehyde
3,4-(methylene dioxy)-1,3-benzodioxole-5-benzaldehyde
3,4-methylene dioxybenzaldehyde
3,4-methylene protocatechuic aldehyde
 piperonal nat.
 piperonyl aldehyde
 protocatechuic aldehyde methylene ether
Synonyms   Articles   Notes   Search   Top
Google Patents: Process for preparing piperonal
PubMed: Can head louse repellents really work? Field studies of piperonal 2% spray.
J-Stage: First Total Synthesis of Justicidone, a p-Quinone-Lignan Derivative from Justicia hyssopifolia
PubMed: Piperonal prevents high-fat diet-induced hepatic steatosis and insulin resistance in mice via activation of adiponectin/AMPK pathway.
J-Stage: Synthesis of Optically Active Olivil Type of Lignan from L-Arabinose Using threo-Selective Aldol Condensation as a Key Reaction
PubMed: Forensic profiling of sassafras oils based on comprehensive two-dimensional gas chromatography.
PubMed: Anticancer activity and biophysical reactivity of copper complexes of 2-(benzo[d][1,3]dioxol-5-ylmethylene)-N-alkylhydrazinecarbothioamides.
PubMed: Enantiomeric HPLC resolution and absolute stereochemistry assignment of a new poligamain derivative.
PubMed: Production of natural fragrance aromatic acids by coexpression of trans-anethole oxygenase and p-anisaldehyde dehydrogenase genes of Pseudomonas putida JYR-1 in Escherichia coli.
PubMed: Synthesis and impurity profiling of MDMA prepared from commonly available starting materials.
PubMed: Synthesis and GC-MS analysis of a series of homologs and regioisomers of 3,4-methylenedioxypyrovalerone (MDPV).
PubMed: Piperonal ciprofloxacin hydrazone induces growth arrest and apoptosis of human hepatocarcinoma SMMC-7721 cells.
PubMed: Selective recognition of sesamol using molecularly imprinted polymers containing magnetic wollastonite.
PubMed: Simultaneous determination of bioactive compounds in Piper nigrum L. and a species comparison study using HPLC-PDA.
PubMed: Availability of target odor compounds from seized ecstasy tablets for canine detection.
PubMed: Half-sandwich ruthenium–arene complexes with thiosemicarbazones: synthesis and biological evaluation of [(η⁶-p-cymene)Ru(piperonal thiosemicarbazones)Cl]Cl complexes.
PubMed: Synthesis and characterization of mixed-ligand diimine-piperonal thiosemicarbazone complexes of ruthenium(II): Biophysical investigations and biological evaluation as anticancer and antibacterial agents.
PubMed: S-selective hydroxynitrile lyase from a plant Baliospermum montanum: molecular characterization of recombinant enzyme.
PubMed: Total synthesis of (+)-virgatusin via AlCl3-catalyzed [3+2] cycloaddition.
PubMed: In vitro biological studies and structural elucidation of fluoro-substituted phenyl acrylic acids.
PubMed: Enhancement in sample collection for the detection of MDMA using a novel planar SPME (PSPME) device coupled to ion mobility spectrometry (IMS).
PubMed: Toxicological methods for tracing drug abuse: chromatographic, spectroscopic and biological characterisation of ecstasy derivatives.
PubMed: Dynamic planar solid phase microextraction-ion mobility spectrometry for rapid field air sampling and analysis of illicit drugs and explosives.
PubMed: Detection of piperonal emitted from polymer controlled odor mimic permeation systems utilizing Canis familiaris and solid phase microextraction-ion mobility spectrometry.
PubMed: N-[(E)-1,3-Benzodioxol-5-yl-methyl-idene]-4-methyl-aniline.
PubMed: Titanium imido complexes utilizing orthometallated derivatized acetophenone and piperonal imine ligands: synthesis, isolation, and characterization.
PubMed: A combined experimental and theoretical study of the polar [3 + 2] cycloaddition of electrophilically activated carbonyl ylides with aldehydes and imines.
PubMed: Adsorbed resin phase spectrophotometric determination of vanillin or/and its derivatives.
PubMed: [Synthesis of pyridine-containing diacylhydrazones and study on their spectral properties].
PubMed: Design, synthesis, and biological evaluation of platensimycin analogues with varying degrees of molecular complexity.
PubMed: Headspace sampling and detection of cocaine, MDMA, and marijuana via volatile markers in the presence of potential interferences by solid phase microextraction-ion mobility spectrometry (SPME-IMS).
PubMed: Synthesis and use of 4-peptidylhydrazido-N-hexyl-1,8-naphthalimides as fluorogenic histochemical substrates for dipeptidyl peptidase IV and tripeptidyl peptidase I.
PubMed: Silenes in organic synthesis: a concise synthesis of (+/-) -epi-picropodophyllin.
PubMed: Electrochemical and spectroscopic characterisation of amphetamine-like drugs: application to the screening of 3,4-methylenedioxymethamphetamine (MDMA) and its synthetic precursors.
PubMed: Alpha-phenyl-N-tert-butyl nitrone (PBN) derivatives: synthesis and protective action against microvascular damages induced by ischemia/reperfusion.
PubMed: Development and validation of an RP-HPLC method for quantitative determination of vanillin and related phenolic compounds in Vanilla planifolia.
PubMed: The fumigant and repellent activity of aliphatic lactones against Pediculus humanus capitis (Anoplura: Pediculidae).
PubMed: Synthesis of 7-deoxypancratistatin from carbohydrates by the use of olefin metathesis.
PubMed: A study of impurities in intermediates and 3,4-methylenedioxymethamphetamine (MDMA) samples produced via reductive amination routes.
PubMed: First total synthesis of justicidone, a p-quinone-lignan derivative from Justicia hyssopifolia.
PubMed: Determination of synthesis method of ecstasy based on the basic impurities.
PubMed: Chemical profiling of 3,4-methylenedioxymethamphetamine (MDMA) tablets seized in Hong Kong.
PubMed: [Succivil efficacy in endogenous intoxication].
PubMed: [Study on the spectrophotometric determination of vanadium with piperonal fluorone by atomic absorption spectrophotometer].
PubMed: [Study on the determination of iron by silica gel H phase-diffuse reflectance spectrometry].
PubMed: Bhc-diol as a photolabile protecting group for aldehydes and ketones.
PubMed: Microbiologic oxidation of isosafrole into piperonal.
PubMed: Concentrations of nine alkenylbenzenes, coumarin, piperonal and pulegone in Indian bidi cigarette tobacco.
PubMed: [Comparative evaluation of antioxidant properties of neoselen and berberin in chronic heliotrinal hepatitis].
PubMed: [Morphological features of the thymus in heliotrin hepatitis upon administration of immunostimulators].
PubMed: A short synthesis of (+/-)-epiasarinin.
PubMed: Antioxidant properties of 8.0.4'-neolignans.
PubMed: Asymmetric Synthesis of Sesaminone: Confirmation of Its Structure and Determination of Its Absolute Configuration.
PubMed: Synthesis of optically active olivil type of lignan from L-arabinose using threo-selective aldol condensation as a key reaction.
PubMed: Histochemical method for dipeptidyl aminopeptidase II with a new anthraquinonyl hydrazide substrate.
PubMed: [The effect of perftoran on the biochemical detoxication parameters in rats with an acute toxic lesion of the liver].
PubMed: Enzyme-assisted asymmetric total synthesis of (-)-podophyllotoxin and (-)-picropodophyllin.
PubMed: Quantitation of flavor-related alkenylbenzenes in tobacco smoke particulate by selected ion monitoring gas chromatography-mass spectrometry.
PubMed: [The effect of immunomudulin on the structural-functional status of the organs of the immune and hematopoietic systems in chronic toxic hepatitis].
PubMed: Solid phase microextraction of alkenylbenzenes and other flavor-related compounds from tobacco for analysis by selected ion monitoring gas chromatography-mass spectrometry.
PubMed: Specificity and sensitivity of a human olfactory receptor functionally expressed in human embryonic kidney 293 cells and Xenopus Laevis oocytes.
PubMed: Cloning, functional expression and characterization of a human olfactory receptor.
PubMed: An Asymmetric Synthesis of L-694,458, a Human Leukocyte Elastase Inhibitor, via Novel Enzyme Resolution of beta-Lactam Esters.
PubMed: Antimutagenic and anticarcinogenic activity of natural and synthetic curcuminoids.
PubMed: Synthesis, anti-GABA activity and preferred conformation of bicuculline and norbicuculline enantiomers.
PubMed: Fragrance administration to reduce anxiety during MR imaging.
PubMed: Head louse repellents.
PubMed: Arena tests with piperonal, a new louse repellent.
PubMed: New head louse repellent.
PubMed: [Contamination in illegal amphetamine. Contaminants resulting from the synthesis of 3,4-(methylenedioxy)amphetamine (MDA) via condensation between nitroethane and piperonal].
PubMed: [Synthesis of derivatives of 2,4-bis(arylmethino)-8-butyl-8- azabicyclo[3.2.1]octan-3-one].
PubMed: Determination of coumarin as an adulterant in vanilla flavoring products by high-performance liquid chromatography.
PubMed: Metabolic disposition of piperine in the rat.
PubMed: Inhibition of rabbit nasal and hepatic cytochrome P-450-dependent hexamethylphosphoramide (HMPA) N-demethylase by methylenedioxyphenyl compounds.
PubMed: Chemosensitivity of lobster,Homarus americanus, to secondary plant compounds: Unused receptor capabilities.
PubMed: Metabolism of piperonal and piperonyl alcohol in the rat with special reference to the scission of the methylenedioxy group.
PubMed: The inhibition of rat nasal cytochrome P-450-dependent mono-oxygenase by the essence heliotropin (piperonal).
PubMed: Genotoxicity of safrole-related chemicals in microbial test systems.
PubMed: The metabolism of some food additives related to piperonal in the rabbit.
PubMed: Quantitative determination of chlorpromazine. HCl in tablets, spansules, injectables, and bulk chemical by nuclear magnetic resonance spectroscopy.
PubMed: [The mechanism of centrolobular hepatic necrosis in acute heliotropin poisoning].
PubMed: [Changes in the antigenic composition of the rat liver in acute and chronic heliotropin poisoning].
PubMed: Correlation of piperonal test values for aromatic compounds with the atmospheric concentration of benzo(A)pyrene.
Synonyms   Articles   Notes   Search   Top
click on the picture(s) below to
interact with the 3D model
Picture of molecule
Soluble in:
 benzyl benzoate
 dipropylene glycol
 fixed oils
 isopropyl myristate
 propylene glycol
 water, 3500 mg/L @ 25 °C (exp)
Insoluble in:
 paraffin oil
 bath foam
 hair spray
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