EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

laevo-glutamine
L-glutamine

Sponsors

Name:(2S)-2,5-diamino-5-oxopentanoic acid
CAS Number: 56-85-9Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:200-292-1
FDA UNII:0RH81L854J
Nikkaji Web:J9.170G
Beilstein Number:1723797
MDL:MFCD00008044
CoE Number:17007
XlogP3:-3.10 (est)
Molecular Weight:130.14710000
Formula:C5 H10 N2 O2
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:special dietary and nutritional additives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
JECFA Food Flavoring:1430 L-glutamine
FLAVIS Number:17.007 (Old)
DG SANTE Food Flavourings:17.007 L-glutamine
FEMA Number:3684 L-glutamine
FDA Mainterm: L-GLUTAMINE
FDA Regulation:
FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION
Subpart D--Special Dietary and Nutritional Additives
Sec. 172.320 Amino acids.
 
Physical Properties:
Appearance:white crystalline powder (est)
Assay: 98.00 to 100.00
Food Chemicals Codex Listed: Yes
Melting Point: 185.00 to 205.00 °C. @ 760.00 mm Hg
Boiling Point: 445.57 °C. @ 760.00 mm Hg (est)
Flash Point:> 200.00 °F. TCC ( > 93.33 °C. )
logP (o/w): -1.576 (est)
Soluble in:
 propylene glycol
 water, 4.221e+004 mg/L @ 25 °C (est)
 water, 4.13E+04 mg/L @ 25 °C (exp)
 
Organoleptic Properties:
Odor Type: milky
Odor Strength:none
milky custard cocoa oily
Odor Description:at 100.00 %. very mild milky custard cocoa oily
Luebke, William tgsc, (2007)
Odor sample from: Penta International Corporation
Flavor Type: sweet
">sweet
Taste Description: slightly sweet
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: antistatic agents
hair conditioning
skin conditioning
 
Suppliers:
Aceto
Glutamine
AIDP
L-Glutamine (Fermented) 98.5%-101.5%
Ajinomoto USA
AjiPure™ Glutamine
AjiPure™
Flavor: characteristic
Manufactured under cGMP conditions using no materials of animal origin.
Ajinomoto USA
L-Glutamine
Flavor: characteristic
Glutamine is nutritionally classified as a nonessential amino acid. It is also considered a conditionally essential amino acid, since its requirement increases significantly in conditions of accelerated catabolism—such as metabolic stress—so that its demand cannot be met by in vivo synthesis alone.
Anhui Haibei
L-Glutamine
Atlantic Chemicals
L-Glutamine
AuNutra® Industries
L-Glutamine
BOC Sciences
For experimental / research use only.
L-Glutamine
Carbosynth
For experimental / research use only.
L-Glutamine 99%
Charkit Chemical
GLUTAMINE, L-
Dow Chemical
L-Glutamine
Foodchem International
L-Glutamine
Glentham Life Sciences
L-Glutamine
Graham Chemical
L-Glutamine
Kerry
Hyprol™ Wheat Protein
Penta International
L-GLUTAMINE, Kosher
Prinova
L-Glutamine FCC
Risun Ingredients
L-Glutamine USP,AJI,FCC
Santa Cruz Biotechnology
For experimental / research use only.
L-Glutamine
Sigma-Aldrich
L-Glutamine
Certified Food Grade Products
Synerzine
L-Glutamine
TCI AMERICA
For experimental / research use only.
L-Glutamine >99.0%(T)
Zhong Ya Chemical
L-Glutamine
 
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
None - None found.
S 02 - Keep out of the reach of children.
S 24/25 - Avoid contact with skin and eyes.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-man TDLo 27 mg/kg/1W-I
BEHAVIORAL: EUPHORIA
American Journal of Psychiatry. Vol. 141, Pg. 1302, 1984.

oral-mouse LD50 21700 mg/kg
Drugs in Japan Vol. 6, Pg. 228, 1982.

oral-rat LD50 7500 mg/kg
Drugs in Japan Vol. 6, Pg. 228, 1982.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: special dietary and nutritional additives
Recommendation for laevo-glutamine usage levels up to:
 not for fragrance use.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 13.00 (μg/capita/day)
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 13
 average usual ppmaverage maximum ppm
baked goods: -350.00000
beverages(nonalcoholic): --
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: --
fruit ices: --
gelatins / puddings: --
granulated sugar: --
gravies: --
hard candy: --
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: -350.00000
milk products: --
nut products: -350.00000
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: -350.00000
snack foods: --
soft candy: -350.00000
soups: --
sugar substitutes: --
sweet sauces: --
 
Safety References:
European Food Safety Athority(efsa):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...
European Food Safety Authority (EFSA) reference(s):
Amino acids from chemical group 34 Flavouring Group Evaluation 26, Revision 1 - Scientific opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf
Flavouring Group Evaluation 29 (FGE29)[1] - Substance from the priority list: Vinylbenzene from chemical group 31 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC)
View page or View pdf
Flavouring Group Evaluation 79, (FGE.79)[1] - Consideration of amino acids and related substances evaluated by JECFA (63rd meeting) structurally related to amino acids from chemical group 34 evaluated by EFSA in FGE.26Rev1 (2008)
View page or View pdf
Scientific Opinion on Flavouring Group Evaluation 49, Revision 1 (FGE.49Rev1): xanthine alkaloids from the priority list
View page or View pdf
EPI System: View
ClinicalTrials.gov:search
Daily Med:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
Env. Mutagen Info. Center:Search
NLM Developmental and Reproductive Toxicity:Search
EPA Substance Registry Services (TSCA):56-85-9
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :5961
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
(2S)-2,5-diamino-5-oxopentanoic acid
Chemidplus:0000056859
RTECS:MA2275100 for cas# 56-85-9
 
References:
 (2S)-2,5-diamino-5-oxopentanoic acid
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:56-85-9
Pubchem (cid):5961
Pubchem (sid):134972923
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS):View
CHEBI:View
CHEMBL:View
Golm Metabolome Database:Search
Metabolomics Database:Search
KEGG (GenomeNet):C00064
HMDB (The Human Metabolome Database):HMDB00641
FooDB:FDB012164
YMDB (Yeast Metabolome Database):YMDB00002
Export Tariff Code:2924.19.8000
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
RSC Learn Chemistry:View
 
Potential Blenders and core components note
For Odor
For Flavor
No flavor group found for these
2-
butyl thiophene
FL
2(4)-iso
butyl-4(2),6-dimethyl dihydro-4H-1,3,5-dithiazine
FL
6-
decenoic acid
FL
4,5-
dimethyl-2-ethyl thiazole
FL
peanut dithiazine
FL
bitter
bitter
methyl ethoxypyrazine
FL
cabbage
methyl 2-thiofuroate
FL
chocolate
cocoa propanal
FL
cocoa
butyraldehyde
FL
coconut
(R)-
massoia lactone
FL
green
2-
ethyl butyraldehyde
FL
milky
dextro,laevo-3-(
methyl thio) butanone
FL
nutty
2,4-
dimethyl-5-vinyl thiazole
FL
 
Potential Uses:
 antistatic agents
 hair conditioning
 skin conditioning
 
Occurrence (nature, food, other):note
 apple plant
Search Trop Picture
 carrot root
Search Trop Picture
 celery root
Search Trop Picture
 cherry sour cherry fruit
Search Trop Picture
 currant black currant fruit juice
Search Trop Picture
 date palm fruit
Search Trop Picture
 garlic bulb
Search Trop Picture
 leek wild leek plant
Search Trop Picture
 onion bulb
Search Trop Picture
 orange fruit
Search Trop Picture
 pineapple fruit
Search Trop Picture
 potato plant
Search Trop Picture
 sage plant
Search Trop Picture
 tarragon leaf
Search Trop Picture
 tarragon root
Search Trop Picture
 tea leaf
Search Trop Picture
 
Synonyms:
 ajipure glutamine
(2S)-2-amino-4-carbamoyl butanoic acid
(2S)-2-amino-4-carbamoylbutanoic acid
L-aminoglutaramic acid
L-2-aminoglutaramic acid
2-aminoglutaramic acid, L-
L-2-aminoglutaramidic acid
laevo-2-aminoglutaramidic acid
 cebrogen
(S)-2,5-diamino-5-oxo-pentanoic acid
(2S)-2,5-diamino-5-oxopentanoic acid
(S)-2,5-diamino-5-oxopentanoic acid
2,5-diamino-5-oxopentanoic acid, (S)-
 glutamic acid 5-amide
L-glutamic acid 5-amide
 glutamic acid amide
L-glutamic acid g-amide
L-glutamic acid gamma-amide
laevo-glutamic acid gamma-amide
L-glutamic acid-5-amide
laevo-glutamic acid-5-amide
L-glutamid
L-glutamide
laevo-glutamide
L-glutamin
(S)-(+)-glutamine
L-glutamine
L-(+)-glutamine
laevo-(+)-glutamine
L-glutamine (fermented)
L-glutamine FCC
 glutamine-S
 glutamine, L-
 levoglutamid
 levoglutamide
 levoglutamina
 miglu-P
 nutrestore
 pentanoic acid, 2,5-diamino-5-oxo-, (S)-
 stimulina
 

Articles:

PubMed:Production and optimization of L-glutaminase enzyme from Hypocrea jecorina pure culture.
PubMed:Efficient expression and purification of recombinant glutaminase from Bacillus licheniformis (GlsA) in Escherichia coli.
PubMed:Kokumi-active glutamyl peptides in cheeses and their biogeneration by Penicillium roquefortii.
PubMed:II. Glutamine and glutamate.
PubMed:Continuous production of extracellular L-glutaminase by Ca-alginate-immobilized marine Beauveria bassiana BTMF S-10 in packed-bed reactor.
PubMed:A simultaneous assay method for L-glutamate and L-pyroglutamate contents in soy sauce using a 5-oxoprolinase (without ATP hydrolyzing activity).
PubMed:Portal hyperglutamatemia after dietary supplementation with monosodium glutamate in pigs.
 
Notes:
a non-essential amino acid present abundantly throughout the body and is involved in many metabolic processes. it is synthesized from glutamic acid and ammonia. it is the principal carrier of nitrogen in the body and is an important energy source for many cells. Widely distributed in plants, e.g. beetroot. Flavouring ingredient. Dietary supplement Glutamine (Gln) is one of the 20 amino acids encoded by the standard genetic code.
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