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tetrahydrofurfuryl alcohol
tetrahydro-2-furanylmethanol

Sponsors

Flavor Demo Formulas
Name:oxolan-2-ylmethanol
CAS Number: 97-99-4Picture of molecule3D/inchi
Other:72074-94-3
ECHA EINECS - REACH Pre-Reg:202-625-6
FDA UNII:XD95821VF9
Nikkaji Web:J4.733C
Beilstein Number:0102723
MDL:MFCD00005372
CoE Number:2029
XlogP3-AA:-0.10 (est)
Molecular Weight:102.13310000
Formula:C5 H10 O2
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
EFSA/JECFA Comments:
Racemate (EFFA, 2010).
Category:flavor and fragrance agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
JECFA Food Flavoring:1443 tetrahydrofurfuryl alcohol
FLAVIS Number:13.020 (Old)
DG SANTE Food Flavourings:13.020 tetrahydrofurfuryl alcohol
FEMA Number:3056 tetrahydrofurfuryl alcohol
FDA:No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm: TETRAHYDROFURFURYL ALCOHOL
FDA Regulation:
FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION
Subpart F--Flavoring Agents and Related Substances
Sec. 172.515 Synthetic flavoring substances and adjuvants.


FDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS
Subpart B--Substances for Use Only as Components of Adhesives
Sec. 175.105 Adhesives.


FDA PART 176 -- INDIRECT FOOD ADDITIVES: PAPER AND PAPERBOARD COMPONENTS
Subpart B--Substances for Use Only as Components of Paper and Paperboard
Sec. 176.180 Components of paper and paperboard in contact with dry food.


FDA PART 176 -- INDIRECT FOOD ADDITIVES: PAPER AND PAPERBOARD COMPONENTS
Subpart B--Substances for Use Only as Components of Paper and Paperboard
Sec. 176.210 Defoaming agents used in the manufacture of paper and paperboard.
 
Physical Properties:
Appearance:colorless clear liquid (est)
Assay: 99.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:1.05000 to 1.05200 @ 25.00 °C.
Pounds per Gallon - (est).: 8.737 to 8.754
Refractive Index:1.44900 to 1.45500 @ 20.00 °C.
Melting Point: -80.00 °C. @ 760.00 mm Hg
Boiling Point: 178.00 to 179.00 °C. @ 760.00 mm Hg
Acid Value: 3.00 max. KOH/g
Vapor Pressure:0.326000 mm/Hg @ 25.00 °C. (est)
Vapor Density:3.52 ( Air = 1 )
Flash Point: 183.00 °F. TCC ( 83.89 °C. )
logP (o/w): -0.367 (est)
Soluble in:
 alcohol
 ethyl ether
 water, 4.634e+005 mg/L @ 25 °C (est)
 water, 1.00E+06 mg/L @ 25 °C (exp)
 
Organoleptic Properties:
Odor Type: vegetable
Odor Strength:medium
vegetable cauliflower warm oily caramellic
Odor Description:at 100.00 %. vegetable cauliflower faint warm oily caramel
Luebke, William tgsc, (1987)
Odor sample from: Sigma-Aldrich
Flavor Type: nutty
">coffee nutty
Taste Description: coffee nut at .03-1 ppm
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: masking agents
solvents
 
Suppliers:
BOC Sciences
For experimental / research use only.
Tetrahydrofurfuryl Alcohol
Lluch Essence
TETRAHYDROFURFURYL ALCOHOL 98%
Penn A Kem
Tetrahydrofurfuryl Alcohol High Purity
Penn A Kem
Tetrahydrofurfuryl Alcohol
Penta International
TETRAHYDROFURFURYL ALCOHOL FCC, Kosher
Penta International
TETRAHYDROFURFURYL ALCOHOL, Kosher
Reincke & Fichtner
Tetrahydrofurfuryl Alcohol
Sigma-Aldrich
Tetrahydrofurfuryl alcohol, ≥98%
Odor: vegetable
Certified Food Grade Products
Synerzine
Tetrahydrofurfuryl Alcohol
SysKem Chemie
Tetrahydrofurfurylalcohol
TCI AMERICA
For experimental / research use only.
Tetrahydrofurfuryl Alcohol >97.0%(GC)
 
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
Xi - Irritant
R 36 - Irritating to eyes.
S 02 - Keep out of the reach of children.
S 25 - Avoid contact with eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36 - Wear suitable protective clothing.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 4500 mg/kg
(Gajewski & Alsdorf, 1949)

intraperitoneal-rat LD50 400 mg/kg
"Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 4658, 1982.

intravenous-rabbit LD50 725 mg/kg
Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 8, Pg. 294, 1949.

oral-mouse LD50 2300 mg/kg
BEHAVIORAL: GENERAL ANESTHETIC
Hygiene and Sanitation Vol. 32(2), Pg. 273, 1967.

intraperitoneal-guinea pig LD50 400 mg/kg
"Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 4658, 1982.

oral-guinea pig LD50 800 mg/kg
"Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 4658, 1982.

oral-rat LD50 1600 mg/kg
"Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 4658, 1982.

Dermal Toxicity:
skin-guinea pig LD50 5000 mg/kg
"Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 4658, 1982.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: flavor and fragrance agents
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 33.00 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 22.00 (μg/capita/day)
Structure Class: III
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
 average usual ppmaverage maximum ppm
baked goods: -0.04000
beverages(nonalcoholic): 0.0300014.00000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: -0.03000
fruit ices: -0.03000
gelatins / puddings: --
granulated sugar: --
gravies: --
hard candy: 0.0300018.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --
 
Safety References:
European Food Safety Athority(efsa):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Flavouring Group Evaluation 33 (FGE.33)[1] - Six Tetrahydrofuran Derivatives from Chemical Groups 13, 14, 16 and 26 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food
View page or View pdf

Flavouring Group Evaluation 75 (FGE.75)[1] - Consideration of tetrahydrofuran derivatives and a furanone derivative evaluated by JECFA (63rd meeting) structurally related to tetrahydrofuran derivatives evaluated by EFSA in FGE.33 (2008)
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 75, Revision 1 (FGE.75Rev1): Consideration of tetrahydrofuran derivatives evaluated by JECFA (63rd meeting) structurally related to tetrahydrofuran derivatives evaluated by EFSA in FGE.33 (2008)
View page or View pdf

EPI System: View
NIOSH International Chemical Safety Cards:search
NLM Hazardous Substances Data Bank:Search
Chemical Carcinogenesis Research Information System:Search
Toxicology Citations:Search
Env. Mutagen Info. Center:Search
EPA Substance Registry Services (TSCA):97-99-4
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :7360
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
oxolan-2-ylmethanol
Chemidplus:0000097994
EPA/NOAA CAMEO:hazardous materials
RTECS:97-99-4
 
References:
 oxolan-2-ylmethanol
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:97-99-4
Pubchem (cid):7360
Pubchem (sid):150424
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS):View
CHEMBL:View
HMDB (The Human Metabolome Database):HMDB31175
FooDB:FDB003193
Export Tariff Code:2932.13.0000
Haz-Map:View
ChemSpider:View
EFSA Update of results on the monitoring of furan levels in food:Read Report
EFSA Previous report: Results on the monitoring of furan levels in food:Read Report
EFSA Report of the CONTAM Panel on provisional findings on furan in food:Read Report
Formulations/Preparations:
•grades: commercial; industrial (80%). •98% grade
 
Potential Blenders and core components note
For Odor
alliaceous
methyl furfuryl disulfide
FL/FR
caramellic
fenugreek absolute
FL/FR
chocolate
cocoa hexenal
FL/FR
2,6-
dimethyl pyrazine
FL/FR
2,4,5-
trimethyl thiazole
FL/FR
earthy
1-
octen-3-ol
FL/FR
ethereal
ethyl pyruvate
FL/FR
fatty
5-
methyl-5-hexen-2-one
FL/FR
fruity
hexanal propylene glycol acetal
FL/FR
2-
pentyl furan
FL/FR
tropical thiazole
FL/FR
green
cortex pyridine
FL/FR
ethyl (E)-2-hexenoate
FL/FR
geranium thiazole
FL/FR
(Z)-4-
heptenal
FL/FR
(Z)-3-
hexen-1-yl (E)-crotonate
FL/FR
(Z)-3-
hexen-1-yl formate
FL/FR
(Z)-3-
hexen-1-yl lactate
FL/FR
(Z)-3-
hexen-1-yl phenyl acetate
FL/FR
(Z)-3-
hexen-1-yl pyruvate
FL/FR
(Z)-3-
hexen-1-yl tiglate
FL/FR
4-
hexenol
FL/FR
hexyl hexanoate
FL/FR
melon nonenoate
FL/FR
2,6-
nonadien-1-ol
FL/FR
2-
octen-1-ol
FL/FR
1-
penten-3-ol
FL/FR
melon
(Z)-6-
nonen-1-ol
FL/FR
minty
iso
propyl tiglate
FL/FR
musty
hazelnut pyrazine
FL/FR
menthofuran
FL/FR
nutty
2-
acetyl-3-methyl pyrazine
FL/FR
4,5-
dimethyl-2-ethyl-3-thiazoline
FL/FR
2,6-
lutidine
FL/FR
2-
methyl thio-3,5 or 6-methyl pyrazine
FL/FR
2-
methyl-3-(methyl thio) pyrazine
FL/FR
vinyl sulfurol
FL/FR
sulfurous
dimethyl disulfide
FL/FR
dimethyl sulfide
FL/FR
grapefruit menthane
FL/FR
lychee mercaptan acetate
FL/FR
methyl 3-(methyl thio) propionate
FL/FR
3-(
methyl thio) hexanol
FL/FR
vegetable
1-
furfuryl pyrrole
FL/FR
mesityl oxide
FL/FR
methional
FL/FR
waxy
methyl octanoate
FL/FR
For Flavor
No flavor group found for these
iso
butyl mercaptan
FL
2-(2-
butyl)-4,5-dimethyl-3-thiazoline
FL
diisopropyl sulfide
FL
2-
ethyl-4,5-dimethyl oxazole
FL
(Z)-3-
hexen-1-yl (E)-crotonate
FL/FR
(E)-4-
hexenal
FL
2-
hexenal
FL
2-
methyl thiazole
FL
4-(
methyl thio) butanol
FL
2-
methyl-3-(methyl thio) pyrazine
FL/FR
2-
methyl-5-methoxythiazole
FL
2-iso
propyl-3-(methyl thio) pyrazine
FL
alliaceous
alliaceous
cyclopentyl mercaptan
FL
2-
methyl thioacetaldehyde
FL
3-
tetrahydrothiophenone
FL
tropical thiazole
FL/FR
caramellic
fenugreek absolute
FL/FR
cocoa
cocoa hexenal
FL/FR
coffee
methyl furfuryl disulfide
FL/FR
ethereal
5-
methyl-5-hexen-2-one
FL/FR
fatty
(E,E)-2,4-
heptadienal
FL
2-
octen-1-ol
FL/FR
(E)-2-
octenoic acid
FL
(E,E)-2,4-
undecadienal
FL
fruity
ethyl (E)-2-hexenoate
FL/FR
hexanal propylene glycol acetal
FL/FR
hexyl hexanoate
FL/FR
green
cortex pyridine
FL/FR
dihydroxyacetophenone (mixed isomers)
FL
geranium thiazole
FL/FR
(Z)-4-
heptenal
FL/FR
(E)-2-
heptenal
FL
(Z)-3-
hexen-1-yl formate
FL/FR
(Z)-3-
hexen-1-yl lactate
FL/FR
(Z)-3-
hexen-1-yl phenyl acetate
FL/FR
(Z)-3-
hexen-1-yl pyruvate
FL/FR
(Z)-3-
hexen-1-yl tiglate
FL/FR
melon nonenoate
FL/FR
methyl octanoate
FL/FR
3-(5-
methyl-2-furyl) butanal
FL
2,6-
nonadien-1-ol
FL/FR
2,4-
octadienal
FL
4-
penten-1-yl acetate
FL
1-
penten-3-ol
FL/FR
2-
pentyl furan
FL/FR
2-
propyl pyrazine
FL
iso
propyl tiglate
FL/FR
propylene glycol acetone ketal
FL
juicy
lychee mercaptan acetate
FL/FR
malty
yeast thiazoline
FL
meaty
3-
mercapto-3-methyl butanol
FL
2-
methyl 3-(methyl thio) furan
FL
metallic
4-
hexenol
FL/FR
3-(
methyl thio) hexanol
FL/FR
mushroom
1-
octen-3-ol
FL/FR
musty
2-
ethoxythiazole
FL
hazelnut pyrazine
FL/FR
menthofuran
FL/FR
nutty
2-
acetyl-3-methyl pyrazine
FL/FR
3,5-
diethyl-2-methyl pyrazine
FL
2,6-
dimethyl pyrazine
FL/FR
4,5-
dimethyl-2-ethyl-3-thiazoline
FL/FR
2,6-
lutidine
FL/FR
2-
methyl thio-3,5 or 6-methyl pyrazine
FL/FR
2,4,5-
trimethyl thiazole
FL/FR
vinyl sulfurol
FL/FR
onion
2-
methyl-1,3-dithiolane
FL
propyl thioacetate
FL
potato
mesityl oxide
FL/FR
roasted
ethyl 3-(furfuryl thio) propionate
FL
rummy
ethyl pyruvate
FL/FR
spicy
jalapeno oleoresin
FL
sulfurous
dimethyl disulfide
FL/FR
dimethyl sulfide
FL/FR
furfuryl methyl sulfide
FL
grapefruit menthane
FL/FR
methyl 2-methyl-3-furyl disulfide
FL
methyl benzyl disulfide
FL
methyl thiomethyl butyrate
FL
potato butanone
FL
tomato
methional
FL/FR
tropical
3-
mercaptohexyl butyrate
FL
vegetable
1-
furfuryl pyrrole
FL/FR
methyl 3-(methyl thio) propionate
FL/FR
radish isothiocyanate
FL
waxy
(Z)-6-
nonen-1-ol
FL/FR
 
Potential Uses:
FLcaramel
FRcastoreum
FRcoffee
 solvents
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
2-furanmethanol, tetrahydro-
 furfuryl alcohol, tetrahydro-
(±)-2-(hydroxymethyl)tetrahydrofuran
2-(hydroxymethyl)tetrahydrofuran
 oxolan-2-ylmethanol
 tetrahydro-2-furan carbinol
 tetrahydro-2-furan methanol
 tetrahydro-2-furancarbinol
 tetrahydro-2-furanmethanol
 tetrahydro-2-furanylmethanol
 tetrahydro-2-furfuryl alcohol
 tetrahydro-2-furyl methanol
 tetrahydro-2-furylmethanol
(tetrahydrofuran-2-yl)methanol
 tetrahydrofuran-2-ylmethanol
a-tetrahydrofurfuryl alcohol
 tetrahydrofurfuryl alcohol FCC
 tetrahydrofurfurylalcohol
 tetrahydrofuryl carbinol
 THFA
 
 
Notes:
Used as a food additive [EAFUS]
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