2,3,5,6-tetramethyl pyrazine
2,3,5,6-tetramethylpyrazine
 
Notes:
found in ligusticum chuanxiong. Isol. from Galbanum oil. Present in french fries, bread, cooked meats, tea, cocoa, coffee, beer, spirits, peanuts, filberts, dairy products and soy products. Fragrance and flavouring ingredient
  • Advanced Biotech
  • Alfrebro
    • Alfrebro LLC
      Let's get reacquainted
      Building great taste with aroma chemicals, extracts, and distillates
      The Alfrebro brand was established in the early 1900s by Alex Fries & Brothers, a Cincinnati Flavor Company. In 1980, the brand was re-launched as an aroma chemical manufacturer. Since its inception, Alfrebro’s primary focus has been to provide quality natural and high value synthetic chemicals.
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      2,3,5,6-TETRAMETHYL PYRAZINE NATURAL 99%
       
  • Apiscent Labs
    • Apiscent Labs, LLC
      Delivery of Quality
      Custom manufacturer and international supplier of fine ingredients.
      We believe inspired chemistry enriches lives. That's why our team is guided by a mission to provide fine ingredients to the worldwide pharmaceutical, flavor and fragrance markets with a primary focus on the manufacturing of value-added, research-based molecules. We're innovative problem solvers committed to excellence at every phase. Our work builds the foundation for our clients' continued success.
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      2, 3, 5, 6 TETRAMETHYLPYRAZINE
       
  • Axxence Aromatic
    • Axxence Aromatic GmbH
      We bring nature to your flavour
      Dedicated to provide the best possible quality and supply service of natural aroma ingredients.
      Axxence Aromatic is entirely dedicated to provide the best possible quality and supply service of natural aroma ingredients to the Flavour & Fragrance Industry worldwide.
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      323700 2,3,5,6-TETRAMETHYL PYRAZINE Natural
       
  • Beijing Lys Chemicals
    • Beijing Lys Chemicals Co, LTD.
      From Grams to Tons
      Fine chemical high-tech company which contains R&D, production, and sales.
      BEIJING LYS CHEMICALS CO, LTD, established in 2004, is a fine chemical high-tech company which contains R&D, production, and sales. We mainly engaged in export and technology development of flavor and fragrance materials and pharmaceutical intermediates. We have nearly 500 kinds of products, from grams to tons, exported to USA, Europe, South Asia and etc. And we custom manufacture new products according to customers’ needs, and serve good quality products and service. Our goal is to become a fine chemical enterprise which could provide special products and services.
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      10032 2,3,5,6-Tetramethyl pyrazine
       
  • Charkit Chemical
    • Charkit Chemical Corporation
      The Specialty Chemical Specialists
      Explore this website to discover the products and services that Charkit provides for your industry and please contact us directly to find out how we can be of service to you.
      Since 1982, Charkit has been committed to expanding the markets we serve and our roster of products and services continues to grow with us. Personal care ingredients now include a substantial array of luxury and exotic components. Substantial inroads have been made in the nutraceutical and resins markets, with a growing roster of versatile and unique ingredients. And we continue to lead the way in our traditional markets such as Metal and Water Treatment, Imaging, Flavor & Fragrance, Aroma and Food. Our Pharmaceutical offerings continue to expand, still anchored by the Boronic Derivatives that meet the demands of Suzuki coupling reactions.
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      TETRAMETHYLPYRAZINE, 2,3,5,6- FEMA 3237
      TETRAMETHYLPYRAZINE, 2,3,5,6- NATURAL FEMA 3237
       
  • Excellentia International
    • Excellentia International
      Ingredients by Nature
      Exceptional quality and excellence in meeting our customers requirements.
      Excellentia International was founded in 2010 through the merger of Excellentia Flavors LLC and Polarome International. Collectively, these companies account for more than one hundred years of industry experience, and are recognized for exceptional quality and excellence in meeting our customers’ requirements.
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      2,3,5,6-TetraMethyl Pyrazine Natural
       
  • FCI SAS
    • FCI SAS
      Inspired by Nature
      At FCI customer service is not a department it’s an attitude.
      Our team is composed of motivated professionals with great experience in the flavours and fragrances market. Our company has been serving this industry for more than 40 years and is ISO 9001 certified since 2009 . Whatever your question on flavour and fragrance ingredients: commercial, technical or regulatory – we will answer it very quickly.
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      50032 2,3,5,6-TETRAMETHYL PYRAZINE
       
  • Fleurchem
    • Fleurchem, Inc.
      Have A Flavorful Day
      A leading global manufacturer and supplier of ingredients for Flavors, Fragrances, AromaTherapy, Foods, Beverages, Personal Care Products, and other uses.
      Operating out of the 200,000 sq. ft., former Hercules/PFW facility in Middletown, NY; Fleurchem produces a full range of natural isolates, synthetic chemicals & specialities, essential oils and flavors. Additionally, the company performs toll manufacturing, as well as custom chemical synthesis for a wide range of clients.
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      Product(s):
      tetramethyl pyrazine natural
      2,3,5,6-tetramethyl pyrazine
       
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  • M&U International
    • M&U International LLC
      Steady supply & demand
      Meeting customers increasing demands at home as well as abroad.
      M&U dedicates itself to the development and production of new products as well as continuously promoting those new products. We’ve maintained a steady supply&demand relationship with a large number of manufacturers at home and abroad. We’ve developed an extensive network and because of our relationships with these manufacturers, we’re able to provide a stable supply of great quality materials. We’re located in China’s largest communications hub, Shanghai and in the U.S. near one of the largest sea ports on the East Coast. The strategic locations of our facilities ensure convenient, prompt and secure delivery of our products to our customers. We warmly welcome your inquiries, come witness our solemn commitment for yourself.
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      H0018 2,3,5,6-TETRAMETHYLPYRAZINE, Kosher
      N0137 NAT.2,3,5,6-TETRAMETHYLPYRAZINE, Kosher
       
  • Moellhausen
    • Moellhausen S.P.A.
      THE CHEMISTRY OF EMOTIONS
      Innovation and commitment in the name of excellence.
      After 50 years in business, Moellhausen stands out as one of the world’s leading family-run companies in the industry of flavors and fragrances, raw materials, and specialties. My personal history is inextricably bound to that of the company, and I continue to dedicate all my energy to it along with our partners and collaborators who have supported us thus far with dedication, passion, love, and experience. Continuous investments and a professionalism aimed at achieving the highest levels of performance in service and quality, along with that same dedication, passion, love, and experience, have together enabled us to reach the absolute avant-garde level that characterizes Moellhausen today, recognized worldwide for its modernity, innovation, creativity, and respect for the environment and the safety and rights of those who work with us. As President and CEO of the company for 32 years, I offer a well-deserved thank you to all of our numerous customers, suppliers, employees, and company friends for helping to sustain our unstoppable and honorable growth. And it is with the support of all of our stakeholders that we will confidently continue to pursue our commitment to further advancing the excellence that our industry demands.
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      Product(s):
      100849 2,3,5,6-TETRAMETHYL PYRAZINE
       
  • Natural Advantage
    • Natural Advantage
      Manufacturer of natural flavor ingredients
      With over 25 years experience in the flavor and food ingredient industries.
      Natural Advantage was formed over seventeen years ago to supply the growing demand for natural food and flavor ingredients. We employ a wide range of multi-disciplined scientists who are dedicated to high quality service, customer satisfaction and creating an outstanding value for our clients.
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      Tetramethyl pyrazine Nat
       
  • Pell Wall Perfumes
    • Pell Wall Perfumes
      Hand-made fragrances
      Pell Wall maintains a broad palette of ingredients & in order to keep stocks fresh & the options wide we also sell from our own stock.
      Pell Wall was founded by perfumer Chris Bartlett to provide exclusive hand-made fragrances to a select few people who love them. All our products are created using fine quality ingredients, many of which we also offer for sale to other perfumers and enthusiasts. Pell Wall make fragrances for men, for women and for the home. If you’re looking for something even more exclusive our bespoke fragrance design service could be what you’re looking for: we design custom fragrances for individuals, other perfume brands, hotels, corporations and organisations.
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      Tetramethyl Pyrazine
      As with all pyrazines this is used in traces – Tetramethyl Pyrazine at 0.1% in Ethanol has a distinctively chocolate odour with elements of roasted nuts and a distinctive tea element. Very useful as part of an authentic chocolate and black tea accords, but must be used with a very light touch.
       
       
  • Penta International
  • Phoenix Aromas & Essential Oils
    • Phoenix Aromas & Essential Oils, Inc.
      EXCEPTIONAL Flavor and Fragrance Ingredients.
      Phoenix sources the finest flavor and fragrance ingredients for its customers.
      Phoenix Aromas & Essential Oils LLC was founded in 1994, grounded in a simple set of core values: provide top-quality products, cost-effective pricing and personalized attention to all our customers. After two decades, we remain committed to those values. With extensive market knowledge of our products, we anticipate, as opposed to merely react, to industry challenges. You can rely on us for all your flavor and fragrance ingredient needs. Customers benefit from Phoenix's long-standing relationships with experienced and reputable growers, processors and manufacturers in key global locations, who are committed to sustainability and green programs. With a strategically located 80,000 sq-ft facility, customers can rely on Phoenix to deliver quality products on time, and cost-effectively.
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      Product(s):
      Pyrazine, 2,3,5,6- Tetramethyl
       
  • Pyrazine Specialties
  • Riverside Aromatics
    • Riverside Aromatics Ltd.
      Speciality Aroma Chemicals, Naturals and Synthetics
      Specialist raw material suppliers to the Flavour & Fragrance Industry.
      Peter Cannon & David Rowe established Riverside Aromatics in 2006 in Poole, UK, to offer a new type of specialist raw material supplier to the Flavour & Fragrance Industry. We bring together over 40 years of commercial & technical experience in the F&F industry which allows us to understand the needs of the Global F&F business and especially that of the West European Market.
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      Product(s):
      TP0200 2,3,5,6-Tetramethylpyrazine
       
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  • Taytonn
    • TAYTONN PTE LTD
      Supplying Asia Pacific
      We fully understand the demands of the F&F industry and we endeavour to supply quality products, with ready availability and a personalised service.
      Since 2001 TAYTONN has been distributing key ingredients to the Fragrance and Flavor industry in Asia. We work closely with customers, principals and vendors. Together we forecast demand and match it with supply of aroma chemicals, essential oils and natural isolates & extracts. Sourced from around the world, our F&F ingredient inventory in Singapore is ready to ship to any location in Asia and beyond. Time and again, we help our principals introduce new discoveries to the F&F market - stimulating creativity and bringing value added proposition to our customers.
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      Product(s):
      2,3,5,6-Tetramethylpyrazine
      Natural Tetramethylpyrazine
       
  • TCI AMERICA
    • TCI AMERICA
      Moving Your Chemistry Forward
      We continuously strive to advance our technology.
      Tokyo Chemical Industry Co., Ltd. (TCI) is a leading worldwide manufacturer of specialty organic chemicals founded in 1946. TCI provides organic laboratory chemicals as well as pharmaceutical, cosmetic and functional materials. More than 60 years of synthesis experience and multi-purpose plants enable TCI to offer more than 27,000 products as well as custom synthesis. TCI established overseas facilities in North America, Europe, China and India to serve customers worldwide.
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      Product(s):
      T0972 2,3,5,6-Tetramethylpyrazine >98.0%(GC)(T)
       
Synonyms   Articles   Notes   Search
    Flavor Demo Formulas
2,3,5,6-tetramethylpyrazine (Click)
CAS Number: 1124-11-4Picture of molecule
ECHA EINECS - REACH Pre-Reg: 214-391-2
FDA UNII: V80F4IA5XG
Nikkaji Web: J39.647H
Beilstein Number: 0113100
MDL: MFCD00006146
CoE Number: 734
XlogP3: 1.30 (est)
Molecular Weight: 136.19764000
Formula: C8 H12 N2
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: cosmetic, flavor and fragrance agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist: Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
JECFA Food Flavoring: 780  2,3,5,6-tetramethylpyrazine
Flavis Number: 14.018 (Old)
DG SANTE Food Flavourings: 14.018  2,3,5,6-tetramethylpyrazine
FEMA Number: 3237  2,3,5,6-tetramethylpyrazine
FDA Mainterm: 2,3,5,6-TETRAMETHYLPYRAZINE
Synonyms   Articles   Notes   Search   Top
Physical Properties:
Appearance: white crystals (est)
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: Yes
Melting Point: 85.00 to  90.00 °C. @ 760.00 mm Hg
Boiling Point: 190.00 °C. @ 760.00 mm Hg
Vapor Pressure: 0.671000 mm/Hg @ 25.00 °C. (est)
Vapor Density: 4.7 ( Air = 1 )
Flash Point: > 200.00 °F. TCC ( > 93.33 °C. )
logP (o/w): 1.280
Soluble in:
 alcohol
 fixed oils
 propylene glycol
 water, 7007 mg/L @ 25 °C (est)
Stability:
 alcoholic fine fragrance, good
 antiperspirant, good
 fabric softener, good
 hypochlorite bleach, poor
 liquid detergent, good
 perborate powder detergent, good
 soap, good
 toiletry application, good
Synonyms   Articles   Notes   Search   Top
Organoleptic Properties:
Odor Type: nutty
Odor Strength: high ,
recommend smelling in a 1.00 % solution or less
 musty  nutty  chocolate  coffee  cocoa  lard  burnt  
Odor Description:
at 1.00 % in dipropylene glycol. 
musty nutty chocolate coffee cocoa soybean lard burnt
 nutty  musty  vanilla  dry  brown  cocoa  
Odor Description:
Nutty, musty and vanilla with dry, brown cocoa nuances
Mosciano, Gerard P&F 22, No. 2, 69, (1997)
 nutty  musty  cocoa  dry  peanut  raw  coffee  
Taste Description:
at 150.00 ppm.  
Nutty, musty, cocoa, drying, peanut-like and raw coffee notes
Mosciano, Gerard P&F 22, No. 2, 69, (1997)
  
Synonyms   Articles   Notes   Search   Top
Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: perfuming agents
Synonyms   Articles   Notes   Search   Top
Suppliers:
Advanced Biotech
2,3,5,6 TETRA METHYL PYRAZINE NATURAL
98% min.
Odor: Cocoa, Nutty
Advanced Biotech
2,3,5,6 TETRAMETHYL PYRAZINE
Alfrebro
2,3,5,6-TETRAMETHYL PYRAZINE NATURAL 99%
Odor: Nutty Chocolate Coffee
Anhui Haibei
2,3,5,6-Tetramethyl Pyrazine
Odor: Sweet musty chocolate tea cocoa soybean lard burnt
Apiscent Labs
2, 3, 5, 6 TETRAMETHYLPYRAZINE
Odor: Roast peanut, filbert, cocoa
Apple Flavor & Fragrance
Tetramethyl pyrazine Natural
Artiste
2,3,5,6-Tetramethyl Pyrazine Natural
Entire library of synthetic pyrazines is available.
Aurochemicals
2,3,5,6-TETRAMETHYL PYRAZINE, Natural
Axxence Aromatic
2,3,5,6-TETRAMETHYL PYRAZINE Natural
Sustainability
Beijing Lys Chemicals
2,3,5,6-Tetramethyl pyrazine
CG Herbals
2,3,5,6-Tetra Methyl Pyrazine
Odor: Weak, Nutty, Musty, Chocolate
Charkit Chemical
TETRAMETHYLPYRAZINE, 2,3,5,6- FEMA 3237
Charkit Chemical
TETRAMETHYLPYRAZINE, 2,3,5,6- NATURAL FEMA 3237
Citrus and Allied Essences
2,3,5,6-Tetramethyl Pyrazine FCC
Odor: fermented soybean
Market Report
De Monchy Aromatics
2,3,5,6-Tetramethylpyrazine
Diffusions Aromatiques
2,3,5,6-TETRAMETHYL PYRAZINE NATURELLE
Diffusions Aromatiques
2,3,5,6-TETRAMETHYL PYRAZINE
EMD Millipore
For experimental / research use only.
2,3,5,6-Tetramethylpyrazine
Ernesto Ventós
2,3,5,6-TETRAMETHYLPYRAZINE NATURAL
Odor: CARAMEL,FERMENTED SOY,ROASTED,COCOA
Ernesto Ventós
2,3,5,6-TETRAMETHYLPYRAZINE
Odor: CARAMEL, FERMENTED SOY, ROASTED
Excellentia International
2,3,5,6-TetraMethyl Pyrazine Natural
FCI SAS
2,3,5,6-TETRAMETHYL PYRAZINE
Odor: Roast peanut, filbert and cocoa
Fleurchem
2,3,5,6-tetramethyl pyrazine
Fleurchem
tetramethyl pyrazine natural
Frutarom
2,3,5,6-TETRAMETHYL PYRAZINE
Frutarom
2,3,5,6-TETRAMETHYLPYRAZINE
≥99.00%, NI, Kosher
Odor: Chocolate, Musty, Roast, Sweet
Use: Suggested Uses: Cheese, Chocolate, Coffee, Dairy Products, Meat, Shellfish, Tea
Frutarom
NATURAL TETRAMETHYLPYRAZINE
≥99.00%, natural, Kosher
Odor: Chocolate, Musty, Roast, Sweet
Use: Suggested Uses: Cheese, Chocolate, Coffee, Dairy Products, Meat, Shellfish, Tea
Indukern F&F
2,3,5,6-TETRAMETHYL PYRAZINE NATURAL
Odor: CHOCOLATE, COFFEE, NUTTY
CROP CALENDAR
Indukern F&F
2,3,5,6-TETRAMETHYL PYRAZINE
Odor: NUTTY, SWEET, LACTONA, COCONUT
Jiangyin Healthway
2,3,5,6-Tetramethyl Pyrazine
New functional food ingredients
Jiangyin Healthway
Tetramethylpyrazine
Jinan Enlighten Chemical Technology(Wutong Aroma )
2,3,5,6-Tetramethyl pyrazine, Kosherk
Kun Shan P&A
2,3,5,6-Natural Tetramethyl Pyrazine (EU)
Lluch Essence
PYRAZINE 2,3,5,6-TETRAMETHYL NATURAL
Lluch Essence
PYRAZINE 2,3,5,6-TETRAMETHYL
M&U International
2,3,5,6-TETRAMETHYLPYRAZINE, Kosher
M&U International
NAT.2,3,5,6-TETRAMETHYLPYRAZINE, Kosher
Matrix Scientific
For experimental / research use only.
2,3,5,6-Tetramethylpyrazine, 95+%
Moellhausen
2,3,5,6-TETRAMETHYL PYRAZINE
Odor: smoke, herbaceous, dry
Flavor: sweet, chocolate, coffee, cocoa, fermented
Natural Advantage
Tetramethyl pyrazine Nat
Pearlchem Corporation
2,3,5,6-Tetramethyl Pyrazine
Pell Wall Perfumes
Tetramethyl Pyrazine
Odor: Nutty, chocolate, roasted, tea. Powerful
Use: As with all pyrazines this is used in traces Tetramethyl Pyrazine at 0.1% in Ethanol has a distinctively chocolate odour with elements of roasted nuts and a distinctive tea element. Very useful as part of an authentic chocolate and black tea accords, but must be used with a very light touch.
Penta International
2,3,5,6-TETRAMETHYL PYRAZINE, NATURAL, Kosher
Penta International
2,3,5,6-TETRAMETHYLPYRAZINE, SYNTHETIC, Kosher
Phoenix Aromas & Essential Oils
Pyrazine, 2,3,5,6- Tetramethyl
Pyrazine Specialties
2,3,5,6-Tetramethylpyrazine
Pyrazine Specialties
2,3,5,6-Tetramethylpyrazines Natural
Reincke & Fichtner
2,3,5,6-Tetramethylpyrazine
Riverside Aromatics
2,3,5,6-Tetramethylpyrazine
Santa Cruz Biotechnology
For experimental / research use only.
2,3,5,6-Tetramethylpyrazine ≥99%
Sigma-Aldrich
2,3,5,6-Tetramethylpyrazine, ≥98%, FG
Odor: chocolate; musty; coffee
Certified Food Grade Products
Sigma-Aldrich
2,3,5,6-Tetramethylpyrazine, natural, ≥98%, FG
Odor: chocolate; musty; coffee
Sunaux International
2,3,5,6-Tetramethylpyrazine
Sunaux International
nat.2,3,5,6-Tetramethylpyrazine
Taytonn
2,3,5,6-Tetramethylpyrazine
Odor: Chocolate, Musty, Roast, Sweet
Taytonn
Natural Tetramethylpyrazine
Odor: Chocolate, Musty, Roast, Sweet
TCI AMERICA
For experimental / research use only.
2,3,5,6-Tetramethylpyrazine >98.0%(GC)(T)
Tengzhou Jitian Aroma Chemiclal
2,3,5,6-Tetramethyl Pyrazine
Tengzhou Xiang Yuan Aroma Chemicals
2,3,5,6-Tetramethyl Pyrazine
The Perfumers Apprentice
Tetramethyl-pyrazine 10% (PG)
Treatt
2,3,5,6-Tetramethylpyrazine
NI, Kosher
Vigon International
Tetramethyl-2,3,5,6 Pyrazine Natural
WEN International
TETRAMETHYL PYRAZINE Natural
Synonyms   Articles   Notes   Search   Top
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
Xn - Harmful.
R 22 - Harmful if swallowed.
R 36/37/38 - Irritating to eyes, respiratory system, and skin.
R 41 - Risk of serious damage to eyes.
S 02 - Keep out of the reach of children.
S 20/21 - When using do not eat, drink or smoke.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 37/39 - Wear suitable gloves and eye/face protection.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
gavage-rat LD50  1910 mg/kg
(Oser, 1969g)

intravenous-mouse LD50  239 mg/kg
Chinese Medical Journal Vol. 4, Pg. 319, 1978.

intraperitoneal-mouse LD50  800 ug/kg
International Journal of Crude Drug Research. Vol. 23, Pg. 119, 1985.

oral-rat LD50  1910 mg/kg
Drug and Chemical Toxicology. Vol. 3, Pg. 249, 1980.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Synonyms   Articles   Notes   Search   Top
Safety in Use Information:
Category: cosmetic, flavor and fragrance agents
Recommendation for 2,3,5,6-tetramethyl pyrazine usage levels up to:
  0.6000 % in the fragrance concentrate.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 6.70 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 19.00 (μg/capita/day)
Structure Class: II
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 4
Click here to view publication 4
 average usual ppmaverage maximum ppm
baked goods: -5.00000
beverages(nonalcoholic): -5.00000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: -10.00000
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: --
fruit ices: --
gelatins / puddings: --
granulated sugar: --
gravies: -10.00000
hard candy: -5.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: -10.00000
milk products: -5.00000
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: -10.00000
sugar substitutes: --
sweet sauces: --
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Safety References:
Flavor & Extract Manufacturers Association (FEMA) reference(s):
The FEMA GRAS assessment of pyrazine derivatives used as flavor ingredients.View pdf
European Food Safety Athority(efsa): Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...
European Food Safety Authority (EFSA) reference(s):
Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the Commission related to Flavouring Group Evaluation 17 (FGE.17): Pyrazine derivatives from chemical group 24 (Commission Regulation (EC) No 1565/2000 of 18 July 2000)
View page or View pdf
Flavouring Group Evaluation 50 (FGE.50): Consideration of pyrazine derivatives evaluated by JECFA (57th meeting) structurally related to pyrazine derivatives evaluated by EFSA in FGE.17 (2005) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf
Flavouring Group Evaluation 17, Revision 1 (FGE.17Rev1): Pyrazine derivatives from chemical group 24 - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) [1]
View page or View pdf
Scientific Opinion on Flavouring Group Evaluation 17, Revision 2 (FGE.17Rev2): Pyrazine derivatives from chemical group 24
View page or View pdf
Scientific Opinion on Flavouring Group Evaluation 50, Revision 1 (FGE.50Rev1): Consideration of pyrazine derivatives evaluated by JECFA (57th meeting) structurally related to pyrazine derivatives evaluated by EFSA in FGE.17Rev2 (2010)
View page or View pdf
Safety and efficacy of pyrazine derivatives including saturated ones belonging to chemical group 24 when used as flavourings for all animal species
View page or View pdf
EPI System: View
Cancer Citations: Search
Toxicology Citations: Search
EPA Substance Registry Services (TSCA): 1124-11-4
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 14296
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 3
 2,3,5,6-tetramethylpyrazine
Chemidplus: 0001124114
RTECS: UQ3905000 for cas# 1124-11-4
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References:
 2,3,5,6-tetramethylpyrazine
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 1124-11-4
Pubchem (cid): 14296
Pubchem (sid): 134980455
Pherobase: View
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS): View
CHEMBL: View
HMDB (The Human Metabolome Database): HMDB36584
FooDB: FDB015495
Export Tariff Code: 2933.99.9700
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
Read: Under the conditions of intended use - New developments in the FEMA GRAS program and the safety assessment of flavor ingredients
Read: A GRAS assessment program for flavor ingredients
Read: Sensory testing for flavorings with modifying properties. Food Technology
Read: Criteria for the safety evaluation of flavoring substances
Read: A procedure for the safety evaluation of natural flavor complexes used as ingredients in food: essential oils
Read: FEMA Expert Panel: 30 Years of safety evaluation for the flavor industry
Read: Consumption ratio and food predominance of flavoring materials
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Potential Blenders and core components note
 
For Odor
balsamic
2-acetyl furanFL/FR
caramellic
 fenugreek oleoresinFL/FR
chocolate
 chocolate pyrazine AFL/FR
 cocoa hexenalFL/FR
2,6-dimethyl pyrazineFL/FR
2,5-dimethyl pyrazineFL/FR
2-methoxy-3-methyl pyrazineFL/FR
2-methyl butyraldehydeFL/FR
coffee
1-hydroxy-2-butanoneFL/FR
earthy
 nutty pyrazineFL/FR
medicinal
 quinolineCS
musty
2-acetyl pyrroleFL/FR
3-acetyl-2,5-dimethyl furanFL/FR
 hazelnut pyrazineFL/FR
 menthofuranFL/FR
nutty
2-acetyl-3-ethyl pyrazineFL/FR
2-acetyl-5-methyl furanFL/FR
2,3-dimethyl pyrazineFL/FR
4,5-dimethyl-2-ethyl-3-thiazolineFL/FR
2-ethyl pyrazineFL/FR
 filbert pyrazineFL/FR
2,6-lutidineFL/FR
2-methyl pyrazineFL/FR
5-methyl quinoxalineFL/FR
2-methyl thio-3,5 or 6-methyl pyrazineFL/FR
 nutty cyclohexenoneFL/FR
 nutty quinoxalineFL/FR
2,3,5-trimethyl pyrazineFL/FR
 vinyl sulfurolFL/FR
popcorn
2-acetyl thiazoleFL/FR
waxy
 butyl laurateFL/FR
 phenethyl octanoateFL/FR
woody
 cedrenyl acetateFR
4-hydroxybenzaldehydeFL/FR
2-methoxy-4-vinyl phenolFL/FR
 
For Flavor
 
No flavor group found for these
 acetyl acetaldehyde dimethyl acetalFL
(E)-aconitic acidFL
2(4)-isobutyl-4(2),6-dimethyl dihydro-4H-1,3,5-dithiazineFL
 chocolate pyrazine AFL/FR
 chocolate pyrazine BFL
 cyclohexyl methyl pyrazineFL
2,5-diethyl thiazoleFL
 peanut dithiazineFL
brown
 fenugreek oleoresinFL/FR
1-hydroxy-2-butanoneFL/FR
cocoa
 cocoa hexenalFL/FR
corn chip
2-acetyl thiazoleFL/FR
creamy
4-hydroxybenzaldehydeFL/FR
fruity
 phenethyl octanoateFL/FR
fusel
2-methyl butyraldehydeFL/FR
musty
2,5-dimethyl pyrazineFL/FR
2,3-dimethyl pyrazineFL/FR
 hazelnut pyrazineFL/FR
 menthofuranFL/FR
2,3,5-trimethyl pyrazineFL/FR
nutty
2-acetyl furanFL/FR
2-acetyl pyrroleFL/FR
3-acetyl-2,5-dimethyl furanFL/FR
2-acetyl-3-ethyl pyrazineFL/FR
2-acetyl-5-methyl furanFL/FR
2,6-dimethyl pyrazineFL/FR
4,5-dimethyl-2-ethyl-3-thiazolineFL/FR
2-ethyl pyrazineFL/FR
 filbert pyrazineFL/FR
2,6-lutidineFL/FR
2-methoxy-3-methyl pyrazineFL/FR
2-methyl pyrazineFL/FR
5-methyl quinoxalineFL/FR
2-methyl thio-3,5 or 6-methyl pyrazineFL/FR
 nutty cyclohexenoneFL/FR
 nutty pyrazineFL/FR
 nutty quinoxalineFL/FR
 nutty thiazoleFL
 peanut oxazoleFL
 vinyl sulfurolFL/FR
smoky
2-methoxy-4-vinyl phenolFL/FR
waxy
 butyl laurateFL/FR
 
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Potential Uses:
 chocolate cocoa 
 coffeeFL
 galbanumFL/FR
 greenFL
 guavaFL
 lard 
 nut filbertFL
 nut macadamiaFL
 nut peanutFL
 soybean 
 sugar brownFL
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Occurrence (nature, food, other): note
 beef roasted beef
Search  Picture
 cheese cheddar cheese
Search  Picture
 cocoa products
Search Trop  Picture
 coconut endosperm
Search Trop  Picture
 coffee
Search  Picture
 dairy products
Search  Picture
 egg boiled egg
Search  Picture
 filbert
Search Trop  Picture
 galbanum
Search Trop  Picture
 guava fruit
Search Trop  Picture
 macadamia nut
Search Trop  Picture
 meat
Search  Picture
 peanut
Search Trop  Picture
 pepper bell pepper fruit
Search Trop  Picture
 rum
Search  Picture
 shrimp
Search  Picture
 soy products
Search  Picture
 soybean seed
Search Trop  Picture
 tea green tea
Search Trop  Picture
 tea leaf
Search Trop  Picture
 whiskey
Search  Picture
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Synonyms:
 chuanxingzine
 ligustrazine
 pyrazine, 2,3,5,6- tetramethyl
 pyrazine, 2,3,5,6-tetramethyl-
2,3,5,6-tetra methyl pyrazine
2,3,5,6-tetramethyl pyrazine
2,3,5,6-tetramethyl pyrazine (natural)
2,3,5,6-tetramethyl pyrazine FCC
 tetramethyl pyrazine natural
2,3,5,6-tetramethyl pyrazine natural
2,3,5,6-tetramethyl pyrazine, natural
 tetramethylpyrazine
2, 3, 5, 6 tetramethylpyrazine
2,3,5,6-tetramethylpyrazine
nat.2,3,5,6-tetramethylpyrazine
2,3,5,6-tetramethylpyrazine natural
2,3,5,6-tetramethylpyrazine, synthetic
2,3,5,6-tetramethylpyrazines natural
 tetrapyrazine
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