EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

2,5-diethyl tetrahydrofuran
2,5-diethyltetrahydrofuran

Sponsors

Name:2,5-diethyloxolane
CAS Number: 41239-48-9Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:255-274-6
FDA UNII:4L4S1F79CT
Nikkaji Web:J89.403F
CoE Number:11882
XlogP3-AA:2.50 (est)
Molecular Weight:128.21472000
Formula:C8 H16 O
NMR Predictor:Predict (works with chrome or firefox)
EFSA/JECFA Comments:
Mixture of stereoisomers (EFFA, 2010). cis (R,S) = (S,R) (50 %), trans (R,R) (25 %) and trans (S,S) (25 %) (EFFA, 2012b).
Category:flavoring agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
JECFA Food Flavoring:1453 2,5-diethyltetrahydrofuran
FLAVIS Number:13.095 (Old)
DG SANTE Food Flavourings:13.095 2,5-diethyltetrahydrofuran
FEMA Number:3743 2,5-diethyltetrahydrofuran
FDA:No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm: 2,5-DIETHYLTETRAHYDROFURAN
FDA Regulation:
FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION
Subpart F--Flavoring Agents and Related Substances
Sec. 172.515 Synthetic flavoring substances and adjuvants.
 
Physical Properties:
Appearance:colorless clear liquid (est)
Assay: 97.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:0.82700 to 0.83300 @ 25.00 °C.
Pounds per Gallon - (est).: 6.881 to 6.931
Refractive Index:1.40100 to 1.40700 @ 20.00 °C.
Boiling Point: 116.00 °C. @ 760.00 mm Hg
Vapor Pressure:3.815000 mm/Hg @ 25.00 °C. (est)
Flash Point: 102.00 °F. TCC ( 38.89 °C. )
logP (o/w): 2.563 (est)
Soluble in:
 alcohol
 water, slightly
 water, 415.4 mg/L @ 25 °C (est)
Insoluble in:
 water
 
Organoleptic Properties:
Odor Type: herbal
Odor Strength:medium ,
recommend smelling in a 0.10 % solution or less
sweet herbal caramellic
Odor Description:at 0.10 % in propylene glycol. sweet herbal caramel
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Axsyn
For experimental / research use only.
Furan,2,5-diethyltetrahydro-
BOC Sciences
For experimental / research use only.
2,5-Diethyloxolane 95%
Parchem
2,5-diethyl tetrahydrofuran
Penn A Kem
2,5-Diethyltetrahydrofuran
Chemical Sources Association
Need This Item for Flavor/Food?: You can contact the Chemical Sources Association
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 [sex: M,F] 3800 mg/kg
(Burdock & Ford, 1990j)

oral-rat LD50 [sex: M,F] 3754 mg/kg
(Reagan & Becci, 1984i)

oral-rat LD50 3400 mg/kg
SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE SKIN AND APPENDAGES (SKIN): HAIR: OTHER GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 1, Pg. 5, 1990.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: flavoring agents
Recommendation for 2,5-diethyl tetrahydrofuran usage levels up to:
 not for fragrance use.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 0.009 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 0.09 (μg/capita/day)
Structure Class: II
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 14
 average usual ppmaverage maximum ppm
baked goods: -10.00000
beverages(nonalcoholic): -5.00000
beverages(alcoholic): -5.00000
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: -5.00000
fruit ices: --
gelatins / puddings: -5.00000
granulated sugar: --
gravies: --
hard candy: --
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: -10.00000
soups: --
sugar substitutes: --
sweet sauces: --
 
Safety References:
European Food Safety Athority(efsa):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Flavouring Group Evaluation 33 (FGE.33)[1] - Six Tetrahydrofuran Derivatives from Chemical Groups 13, 14, 16 and 26 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food
View page or View pdf

Flavouring Group Evaluation 75 (FGE.75)[1] - Consideration of tetrahydrofuran derivatives and a furanone derivative evaluated by JECFA (63rd meeting) structurally related to tetrahydrofuran derivatives evaluated by EFSA in FGE.33 (2008)
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 75, Revision 1 (FGE.75Rev1): Consideration of tetrahydrofuran derivatives evaluated by JECFA (63rd meeting) structurally related to tetrahydrofuran derivatives evaluated by EFSA in FGE.33 (2008)
View page or View pdf

EPI System: View
EPA Substance Registry Services (TSCA):41239-48-9
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :62913
National Institute of Allergy and Infectious Diseases:Data
2,5-diethyloxolane
Chemidplus:0041239489
 
References:
 2,5-diethyloxolane
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:41239-48-9
Pubchem (cid):62913
Pubchem (sid):135020219
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS):View
HMDB (The Human Metabolome Database):HMDB29574
FooDB:FDB000729
Export Tariff Code:2932.19.0000
Typical G.C.
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
EFSA Update of results on the monitoring of furan levels in food:Read Report
EFSA Previous report: Results on the monitoring of furan levels in food:Read Report
EFSA Report of the CONTAM Panel on provisional findings on furan in food:Read Report
 
Potential Blenders and core components note
For Odor
buttery
acetoin
FL/FR
caramellic
caramel pentadione
FL/FR
cyclotene
FL/FR
cyclotene hydrate
FL/FR
alpha,alpha-
dimethyl anisyl acetone
FL/FR
ethyl 2-hydroxy-2-methyl butyrate
FL/FR
ethyl cyclopentenolone
FL/FR
ethyl maltol
FL/FR
5-
ethyl-2,3,4,5-tetramethyl-2-cyclohexen-1-one
FL/FR
fenugreek absolute
FL/FR
geranyl crotonate
FR
immortelle absolute
FL/FR
maltol
FL/FR
maltyl propionate
FL/FR
maple furanone
FL/FR
menthone lactone
FL/FR
mesitene lactone
FR
rosefuran
FL/FR
shoyu furanone
FL/FR
strawberry furanone
FL/FR
toffee furanone
FL/FR
coumarinic
tonka bean resinoid
FR
ethereal
iso
valeraldehyde propylene glycol acetal
FL/FR
fatty
(R)-gamma-
decalactone
FL/FR
moldy
strawberry furanone methyl ether
FL/FR
sweet
vanilla oleoresin bali
FL/FR
vanilla
vanilla bean absolute (vanilla planifolia)
FL/FR
For Flavor
No flavor group found for these
2-
acetyl-3,4,5,6-tetrahydropyridine
FL
allyl 2-furoate
FL
(R)-gamma-
decalactone
FL/FR
alpha,alpha-
dimethyl anisyl acetone
FL/FR
ethyl 2-hydroxy-2-methyl butyrate
FL/FR
5-
ethyl-2,3,4,5-tetramethyl-2-cyclohexen-1-one
FL/FR
menthone lactone
FL/FR
rosefuran
FL/FR
burnt
burnt
furfuryl alcohol
FL
caramellic
caramel furanone
FL
caramel pentadione
FL/FR
cyclotene
FL/FR
cyclotene hydrate
FL/FR
ethyl maltol
FL/FR
5-
ethyl-3,4,5,6-tetramethyl cyclohexen-2-one
FL
fenugreek absolute
FL/FR
maltol
FL/FR
maltyl propionate
FL/FR
maple furanone
FL/FR
shoyu furanone
FL/FR
strawberry furanone
FL/FR
toffee furanone
FL/FR
creamy
acetoin
FL/FR
fatty
(E,E)-2,4-
undecadienal
FL
2,4-
undecadienal
FL
fruity
2-
pentanoyl furan
FL
iso
valeraldehyde propylene glycol acetal
FL/FR
green
immortelle absolute
FL/FR
jammy
ethyl cyclopentenolone
FL/FR
moldy
strawberry furanone methyl ether
FL/FR
smoky
dextro-
xylose
FL
sweet
caramel dione
FL
vanilla oleoresin bali
FL/FR
vanilla
vanilla bean absolute (vanilla planifolia)
FL/FR
 
Potential Uses:
FLcaramel
FLmint
 
Occurrence (nature, food, other):note
 caper
Search Trop Picture
 melissa oil slovak republic @ 0.08%
Data GC Search Trop Picture
 thymus capitatus
Search Trop Picture
 
Synonyms:
2,5-diethyl oxolane
2,5-diethyloxolane
2,5-diethyltetrahydrofuran
 furan, 2,5-diethyltetrahydro-
 

Articles:

 None found yet.
 
Notes:
Used in flavour compositions. Present in Spanish origanum (Coridothymus capitatus) and lemon balm (Melissa officinalis)
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