EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

ortho-dimethyl hydroquinone
1,2-dimethoxybenzene

Sponsors

Name:1,2-dimethoxybenzene
CAS Number: 91-16-7Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:202-045-3
FDA UNII:61WJZ2Q41I
Nikkaji Web:J4.334F
Beilstein Number:1364621
MDL:MFCD00008357
CoE Number:10320
XlogP3:1.60 (est)
Molecular Weight:138.16610000
Formula:C8 H10 O2
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:flavor and fragrance agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
JECFA Food Flavoring:1248 1,2-dimethoxybenzene
FLAVIS Number:04.062 (Old)
DG SANTE Food Flavourings:04.062 1,2-dimethoxybenzene
FEMA Number:3799 1,2-dimethoxybenzene
FDA:No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm: 1,2-DIMETHOXYBENZENE
 
Physical Properties:
Appearance:colorless clear liquid (est)
Assay: 98.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:1.08200 to 1.08600 @ 25.00 °C.
Pounds per Gallon - (est).: 9.003 to 9.037
Refractive Index:1.53300 to 1.53600 @ 20.00 °C.
Melting Point: 22.50 °C. @ 760.00 mm Hg
Boiling Point: 206.00 °C. @ 760.00 mm Hg
Vapor Pressure:0.470000 mm/Hg @ 25.00 °C.
Flash Point: 189.00 °F. TCC ( 87.22 °C. )
logP (o/w): 1.600
Soluble in:
 alcohol
 water, 3666 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor Type: vanilla
Odor Strength:medium ,
recommend smelling in a 1.00 % solution or less
sweet creamy vanilla phenolic musty
Odor Description:at 1.00 % in dipropylene glycol. sweet creamy vanilla phenolic musty
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: perfuming agents
 
Suppliers:
Beijing Lys Chemicals
1,2-Dimethoxy benzene
BOC Sciences
For experimental / research use only.
1,2-Dimethoxybenzene
CG Herbals
Veratrole
ExtraSynthese
For experimental / research use only.
Guaiacol methylether
Jinan Enlighten Chemical Technology(Wutong Aroma )
1,2-Dimethoxybenzene
M&U International
1,2-DIMETHOXYBENZENE, Kosher
Penta International
VERATROLE, Kosher
Reincke & Fichtner
Veratrole
Santa Cruz Biotechnology
For experimental / research use only.
1,2-Dimethoxybenzene ≥99%
Sigma-Aldrich
1,2-Dimethoxybenzene, ≥99%, FG
Odor: creamy; vanilla.
Certified Food Grade Products
Sinoway Industrial
For experimental / research use only.
Veratrole
TCI AMERICA
For experimental / research use only.
1,2-Dimethoxybenzene >99.0%(GC)
 
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
Xn - Harmful.
R 22 - Harmful if swallowed.
S 02 - Keep out of the reach of children.
S 20/21 - When using do not eat, drink or smoke.
S 36 - Wear suitable protective clothing.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-mouse LD50 700 mg/kg
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 26(2), Pg. 54, 1982.

oral-rat LD50 890 mg/kg
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 26(2), Pg. 54, 1982.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: flavor and fragrance agents
Recommendation for ortho-dimethyl hydroquinone usage levels up to:
  0.2000 % in the fragrance concentrate.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 1.60 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 20.00 (μg/capita/day)
Structure Class: I
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 17
 average usual ppmaverage maximum ppm
baked goods: 0.300003.00000
beverages(nonalcoholic): 0.100001.00000
beverages(alcoholic): 0.200002.00000
breakfast cereal: --
cheese: --
chewing gum: 15.0000030.00000
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: --
fruit ices: --
gelatins / puddings: 0.300003.00000
granulated sugar: --
gravies: --
hard candy: 0.500005.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: 0.100001.00000
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: 0.500005.00000
soups: --
sugar substitutes: --
sweet sauces: --
 
Safety References:
European Food Safety Athority(efsa):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Flavouring Group Evaluation 23 (FGE.23): Aliphatic, alicyclic and aromatic ethers including anisole derivatives From chemical groups 15, 16 and 26 (Commission Regulation (EC) No 1565/2000 of 18 July 2000
View page or View pdf

Flavouring Group Evaluation 59 (FGE.59): Consideration of aliphatic and aromatic ethers evaluated by JECFA (61st meeting) structurally related to aliphatic, alicyclic and aromatic ethers including anisole derivatives evaluated by EFSA in FGE.23 (2006) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf

Flavouring Group Evaluation 23, Revision 1 (FGE.23Rev1): Aliphatic, alicyclic and aromatic ethers including anisole derivatives from chemical groups 15, 16, 26 and 30[1] - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 59, Revision 1 (FGE.59Rev1): Consideration of aliphatic and aromatic ethers evaluated by JECFA (61st meeting and 63rd meeting) structurally related to aliphatic, alicyclic and aromatic ethers including anisole derivatives evaluated by EFSA in FGE.23 Rev2 (2010)
View page or View pdf

EPI System: View
Cancer Citations:Search
Toxicology Citations:Search
Env. Mutagen Info. Center:Search
EPA Substance Registry Services (TSCA):91-16-7
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :7043
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
1,2-dimethoxybenzene
Chemidplus:0000091167
RTECS:CZ6475000 for cas# 91-16-7
 
References:
 1,2-dimethoxybenzene
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:91-16-7
Pubchem (cid):7043
Pubchem (sid):134971437
Pherobase:View
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS):View
CHEBI:View
CHEMBL:View
Metabolomics Database:Search
HMDB (The Human Metabolome Database):HMDB32139
FooDB:FDB008865
Export Tariff Code:2909.30.6000
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
RSC Learn Chemistry:View
 
Potential Blenders and core components note
For Odor
No odor group found for these
butter starter distillates
FL/FR
heptanal diethyl acetal
FL/FR
acidic
acidic
iso
butyric acid
FL/FR
2-
ethyl butyric acid
FL/FR
2-
methyl butyric acid
FL/FR
aldehydic
acetyl nonyryl
FL/FR
2-
tridecenal
FL/FR
anisic
para-
anisaldehyde
FL/FR
bready
coffee furanone
FL/FR
buttery
acetoin
FL/FR
acetyl butyryl
FL/FR
acetyl isobutyryl
FL/FR
acetyl propionyl
FL/FR
butyl butyryl lactate
FL/FR
caramellic
2-oxo
butyric acid
FL/FR
levulinic acid
FL/FR
cheesy
butyric acid
FL/FR
2-
methyl hexanoic acid
FL/FR
iso
valeric acid
FL/FR
valeric acid
FL/FR
chocolate
vanillyl ethyl ether
FL/FR
citrus
methyl heptenone
FL/FR
coconut
alpha-
angelica lactone
FL/FR
coconut decanone methyl
FR
delta-
decalactone
FL/FR
delta-2-
dodecenolactone
FL/FR
delta-
nonalactone
FL/FR
gamma-
nonalactone (aldehyde C-18 (so-called))
FL/FR
gamma-
octalactone
FL/FR
delta-
octalactone
FL/FR
delta-
undecalactone
FL/FR
coumarinic
epsilon-
decalactone
FL/FR
creamy
butyl lactate
FL/FR
gamma-
butyrolactone
FL/FR
creamy lactone
FL/FR
geranyl ethyl acetal
FR
3-
heptyl dihydro-5-methyl-2(3H)-furanone
FL/FR
(Z)-gamma-
jasmolactone
FR
delta-
tridecalactone
FL/FR
para-
vanillic acid
FL/FR
para-
vanillyl alcohol
FL/FR
veratraldehyde
FL/FR
waxy lactone
FL/FR
earthy
1-
nonen-3-ol
FL/FR
3-
octanol
FL/FR
2-
octanone
FL/FR
3-
octen-2-one
FL/FR
1-
octen-3-one
FL/FR
ethereal
iso
valeraldehyde propylene glycol acetal
FL/FR
fatty
butter esters
FL/FR
(Z)-
dairy lactone
FL/FR
(Z)-
ethyl oleate
FL/FR
ethyl undecylenate
FL/FR
4-
methyl octanoic acid
FL/FR
fermented
butyl laevo-lactate
FL/FR
floral
dihydrojasmone lactone
FL/FR
heliotropin
FL/FR
hexenyl cyclopentanone
FR
jasmin pyranone
FL/FR
para-
methyl acetophenone
FL/FR
fresh
10-
undecen-1-yl acetate
FL/FR
fruity
acetoin acetate
FL/FR
bitter
almond oil
FL/FR
iso
amyl 2-methyl butyrate
FL/FR
butyl 2-decenoate
FL/FR
gamma-
decalactone
FL/FR
ethyl lactate
FL/FR
farnesyl acetone
FL/FR
methyl (Z)-5-octenoate
FL/FR
methyl butyrate
FL/FR
methyl valerate
FL/FR
2-
nonanone
FL/FR
octen-1-yl cyclopentanone
FL/FR
octyl butyrate
FL/FR
sorbyl butyrate
FL/FR
gamma-
undecalactone (aldehyde C-14 (so-called))
FL/FR
2-
undecanone
FL/FR
green
iso
butyl benzyl carbinol
FL/FR
iso
butyl methyl ketone
FL/FR
3-
heptanone
FL/FR
(Z)-4-
hepten-1-ol
FL/FR
3-
hepten-2-one
FL/FR
(Z)-4-
heptenal
FL/FR
(Z)-4-
heptenal diethyl acetal
FL/FR
2-
heptyl furan
FL/FR
methyl heptine carbonate
FL/FR
herbal
herbal ketone
FR
1-
octen-3-yl acetate
FL/FR
lactonic
jasminone
FL/FR
mushroom
3-
octen-2-ol
FL/FR
musk
iso
ambrettolide
FL/FR
omega-
pentadecalactone
FL/FR
nutty
resorcinol
FR
oily
butter acids
FL/FR
powdery
para-
anisyl alcohol
FL/FR
soapy
ethyl undecanoate
FL/FR
spicy
4-
methyl guaiacol
FL/FR
sulfurous
dimethyl sulfide
FL/FR
methyl mercaptan
FL/FR
sweet
vanilla oleoresin bali
FL/FR
tonka
6-
amyl-alpha-pyrone
FL/FR
gamma-
hexalactone
FL/FR
mint lactone
FL/FR
octahydrocoumarin
FL/FR
whiskey lactone
FL/FR
tropical
delta-
dodecalactone
FL/FR
vanilla
ethyl vanillin
FL/FR
ethyl vanillin hexylene glycol acetal
FR
ethyl vanillin isobutyrate
FL/FR
ethyl vanillin propylene glycol acetal
FL/FR
propenyl guaethol
FL/FR
vanillin
FL/FR
vanillin hexylene glycol acetal
FR
vanillin propylene glycol acetal
FL/FR
vanillyl acetate
FL/FR
vanillyl isobutyrate
FL/FR
vanillylidene acetone
FL/FR
vegetable
methional
FL/FR
waxy
allyl nonanoate
FL/FR
iso
amyl laurate
FL/FR
butyl laurate
FL/FR
9-
decenoic acid
FL/FR
ethyl laurate
FL/FR
ethyl myristate
FL/FR
ethyl octanoate
FL/FR
ethyl palmitate
FL/FR
methyl laurate
FL/FR
myristic acid
FL/FR
nonanoic acid
FL/FR
2-
nonanol
FL/FR
octyl 2-methyl butyrate
FL/FR
octyl isobutyrate
FL/FR
phenethyl octanoate
FL/FR
delta-
tetradecalactone
FL/FR
2-
tridecanone
FL/FR
undecanoic acid
FL/FR
woody
4-
hydroxybenzaldehyde
FL/FR
sandal butenol
FR
For Flavor
No flavor group found for these
allyl methyl trisulfide
FL
6-
decenoic acid
FL
2,5-
dithiahexane
FL
delta-2-
dodecenolactone
FL/FR
farnesyl acetone
FL/FR
heptanal 2,3-butane diol acetal
FL
3-
hydroxy-4-phenyl-2-butanone
FL
3-
methyl crotonic acid
FL
methyl propyl sulfide
FL
S-
methyl thiopropionate
FL
mouth-feel builder
FL
3-(
methyl thio) methyl thiophene
FL
acidic
acidic
iso
butyric acid
FL/FR
2-
ethyl butyric acid
FL/FR
levulinic acid
FL/FR
propionic acid
FL
valeric acid
FL/FR
aldehydic
acetyl nonyryl
FL/FR
2-
tridecenal
FL/FR
amber
iso
butyl benzyl carbinol
FL/FR
ammoniacal
2-
methyl piperidine
FL
balsamic
vanillylidene acetone
FL/FR
bitter
glyceryl tributyrate
FL
brown
2-oxo
butyric acid
FL/FR
buttery
butter starter distillates
FL/FR
butyl laevo-lactate
FL/FR
diacetyl
FL
cabbage
methyl 2-thiofuroate
FL
caramellic
5-
ethyl-3,4,5,6-tetramethyl cyclohexen-2-one
FL
pyruvaldehyde
FL
celery
jasminone
FL/FR
cheesy
methyl ketones
FL
2-
nonanone
FL/FR
iso
valeric acid
FL/FR
cherry
heliotropin
FL/FR
coconut
delta-
decalactone
FL/FR
(R)-
massoia lactone
FL
6-
methyl coumarin
FL
gamma-
nonalactone (aldehyde C-18 (so-called))
FL/FR
octahydrocoumarin
FL/FR
delta-
octalactone
FL/FR
creamy
acetoin
FL/FR
acetoin butyrate
FL
acetyl butyryl
FL/FR
acetyl isobutyryl
FL/FR
6-
amyl-alpha-pyrone
FL/FR
alpha-
angelica lactone
FL/FR
para-
anisaldehyde
FL/FR
butter esters
FL/FR
butyl butyryl lactate
FL/FR
cream enhancers
FL
creamy lactone
FL/FR
dihydrocoumarin
FL
divanillin
FL
delta-
dodecalactone
FL/FR
heptanal diethyl acetal
FL/FR
3-
hepten-2-one
FL/FR
gamma-
hexalactone
FL/FR
4-
hydroxybenzaldehyde
FL/FR
jasmin pyranone
FL/FR
para-
methyl acetophenone
FL/FR
mint lactone
FL/FR
delta-
nonalactone
FL/FR
3-
octen-2-one
FL/FR
octyl isobutyrate
FL/FR
2-
propanoyl thiophene
FL
delta-
tridecalactone
FL/FR
delta-
undecalactone
FL/FR
gamma-
undecalactone (aldehyde C-14 (so-called))
FL/FR
para-
vanillic acid
FL/FR
para-
vanillyl alcohol
FL/FR
veratraldehyde
FL/FR
waxy lactone
FL/FR
dairy
butyl lactate
FL/FR
dairy enhancers
FL
methyl (Z)-5-octenoate
FL/FR
2-
octanone
FL/FR
earthy
1-
nonen-3-ol
FL/FR
1-
octen-3-one
FL/FR
fatty
iso
amyl laurate
FL/FR
butter acids
FL/FR
(Z)-
dairy lactone
FL/FR
diacetyl trimer
FL
(Z)-
ethyl oleate
FL/FR
ethyl undecylenate
FL/FR
2-
heptyl furan
FL/FR
4-
methyl octanoic acid
FL/FR
nonanoic acid
FL/FR
2,4-
octadien-1-ol
FL
2-
tridecanone
FL/FR
fermented
methyl thio isovalerate
FL
fruity
acetoin acetate
FL/FR
acetyl isovaleryl
FL
bitter
almond oil
FL/FR
iso
amyl 2-methyl butyrate
FL/FR
para-
anisyl alcohol
FL/FR
butyl 2-decenoate
FL/FR
gamma-
decalactone
FL/FR
ethyl lactate
FL/FR
3-
heptyl dihydro-5-methyl-2(3H)-furanone
FL/FR
2-
methyl butyric acid
FL/FR
methyl valerate
FL/FR
octen-1-yl cyclopentanone
FL/FR
phenethyl octanoate
FL/FR
sorbyl butyrate
FL/FR
iso
valeraldehyde propylene glycol acetal
FL/FR
fusel
methyl butyrate
FL/FR
greasy
10-
undecen-1-yl acetate
FL/FR
green
iso
butyl methyl ketone
FL/FR
(Z)-4-
hepten-1-ol
FL/FR
(Z)-4-
heptenal
FL/FR
(Z)-4-
heptenal diethyl acetal
FL/FR
(E)-3-
hexenoic acid
FL
methyl heptenone
FL/FR
methyl heptine carbonate
FL/FR
1-
octen-3-yl acetate
FL/FR
ketonic
3-
heptanone
FL/FR
lactonic
gamma-
octalactone
FL/FR
meaty
4-
allyl-2,6-dimethoxyphenol
FL
milky
gamma-
butyrolactone
FL/FR
mushroom
3-
octen-2-ol
FL/FR
musk
iso
ambrettolide
FL/FR
musty
3-
octanol
FL/FR
nutty
coffee furanone
FL/FR
oily
2-
methyl hexanoic acid
FL/FR
powdery
powdery ketone
FL
rummy
vanillyl ethyl ether
FL/FR
sour
butyric acid
FL/FR
spicy
benzylidene acetone
FL
sulfurous
dimethyl sulfide
FL/FR
methyl mercaptan
FL/FR
1-(
methyl thio)-2-butanone
FL
methyl thioacetate
FL
2-
naphthyl mercaptan
FL
sweet
vanilla oleoresin bali
FL/FR
toasted
acetyl propionyl
FL/FR
tomato
methional
FL/FR
vanilla
ethyl vanillin
FL/FR
ethyl vanillin isobutyrate
FL/FR
ethyl vanillin propylene glycol acetal
FL/FR
4-
methyl guaiacol
FL/FR
omega-
pentadecalactone
FL/FR
propenyl guaethol
FL/FR
vanillin
FL/FR
vanillin propylene glycol acetal
FL/FR
vanillyl acetate
FL/FR
vanillyl isobutyrate
FL/FR
waxy
allyl nonanoate
FL/FR
butyl laurate
FL/FR
epsilon-
decalactone
FL/FR
9-
decenoic acid
FL/FR
dihydrojasmone lactone
FL/FR
ethyl laurate
FL/FR
ethyl myristate
FL/FR
ethyl octanoate
FL/FR
ethyl palmitate
FL/FR
ethyl undecanoate
FL/FR
methyl laurate
FL/FR
myristic acid
FL/FR
2-
nonanol
FL/FR
octyl 2-furoate
FL
octyl 2-methyl butyrate
FL/FR
octyl butyrate
FL/FR
delta-
tetradecalactone
FL/FR
undecanoic acid
FL/FR
2-
undecanone
FL/FR
woody
whiskey lactone
FL/FR
 
Potential Uses:
FRcoffee
FRcream
FLdairy
FRvanilla
 
Occurrence (nature, food, other):note
 coffee
Search PMC Picture
 corn husk oil
Search Trop Picture
 curry
Search Trop Picture
 pandanus latifolius
Search Trop Picture
 rice cooked rice
Search PMC Picture
 tea leaf
Search Trop Picture
 
Synonyms:
 benzene, 1,2-dimethoxy-
 benzene, dimethoxy-
 catechol dimethyl ether
 catecholdimethyl ether
1,2-dimethoxy benzene
1,2-dimethoxy-benzene
1,2-dimethoxybenzene
o-dimethoxybenzene
ortho-dimethoxybenzene
1,2-dimethoxybenzol
2-dimethoxybenzol
o-dimethyl hydroquinone
ortho-dimethyl hydroquinone
o-dimethylhydroquinone
ortho-dimethylhydroquinone
 guaiacol methylether
2-methoxyanisole
 pyrocatechol dimethyl ether
 pyrocatecholdimethyl ether
 synthol
 veratrol
 veratrole
 
 
Notes:
Food additive listed in the EAFUS Food Additive Database (Jan 2001). Found in raw and cooked foods, e.g. cheeses, grapes and asparagus 1,2-Dimethoxybenzene, commonly known as veratrole, is a chemical compound with the formula C6H4(OCH3)2. It is the dimethyl ether derived from pyrocatechol. Veratrole is slightly soluble in water, but miscible in all organic solvents. It is a building block for the organic synthesis of other aromatic compounds. Veratrole is relatively electron-rich and thus readily undergoes electrophilic substitution.
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