EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

para-vanillic acid
4-hydroxy-3-methoxybenzoic acid

Sponsors

Name:4-hydroxy-3-methoxybenzoic acid
CAS Number: 121-34-6Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:204-466-8
Nikkaji Web:J5.337F
Beilstein Number:2208364
MDL:MFCD00002551
CoE Number:697
XlogP3:1.40 (est)
Molecular Weight:168.14856000
Formula:C8 H8 O4
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:flavor and fragrance agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
JECFA Food Flavoring:959 4-hydroxy-3-methoxy benzoic acid
FLAVIS Number:08.043 (Old)
DG SANTE Food Flavourings:08.043 vanillic acid
FEMA Number:3988 4-hydroxy-3-methoxybenzoic acid
FDA Mainterm: VANILLIC ACID
 
Physical Properties:
Appearance:white to beige powder (est)
Assay: 98.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 210.00 to 213.00 °C. @ 760.00 mm Hg
Boiling Point: 353.43 °C. @ 760.00 mm Hg (est)
Vapor Pressure:0.000020 mm/Hg @ 25.00 °C.
Flash Point:> 212.00 °F. TCC ( > 100.00 °C. )
logP (o/w): 1.430
Soluble in:
 alcohol, 5% slightly hazy
 dipropylene glycol
 water, 1500 mg/L @ 14C (exp)
Insoluble in:
 water
 
Organoleptic Properties:
Odor Type: creamy
Odor Strength:medium
dairy milky sweet creamy powdery vanilla beany
Odor Description:at 100.00 %. dairy milky sweet creamy powdery vanilla bean
Luebke, William tgsc, (2007)
Odor sample from: Sigma-Aldrich
sweet creamy phenolic brown powdery vanilla beany
Odor Description:Sweet creamy, phenolic, brown and powdery with vanilla beany nuances
Mosciano, Gerard P&F 18, No. 4, 51, (1993)
Flavor Type: creamy
creamy milky sweet vanilla powdery
Taste Description: at 30.00 ppm. Creamy, milky, sweet and vanilla with cardboard-like nuances
Mosciano, Gerard P&F 18, No. 4, 51, (1993)
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Apiscent Labs
VANILLIC ACID
Odor: Vanilla
Beijing Lys Chemicals
Vanillic acid
BOC Sciences
For experimental / research use only.
p-Vanillic Acid >98%
Coompo
For experimental / research use only.
Vanillic Acid from Plants ≥96%
ExtraSynthese
For experimental / research use only.
Vanillic Acid (HPLC) ≥95%
Frinton Laboratories
For experimental / research use only.
Vanillic Acid
Lluch Essence
VANILLIC ACID
Penta International
VANILLIC ACID, Kosher
Penta International
VANILLIC ACID, TECH. GRADE, Kosher
Shijiazhuang Donglian Nankai Aroma Chemicals
Vanillic Acid
Odor: Sweet milk and vanillia bean
Sigma-Aldrich
Vanillic acid, ≥97%, FG
Odor: chocolate; creamy; grape; nutty; wine-like
Certified Food Grade Products
Synerzine
Vanillic Acid
TCI AMERICA
For experimental / research use only.
Vanillic Acid >98.0%(GC)(T)
 
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
None - None found.
S 02 - Keep out of the reach of children.
S 22 - Do not breath dust.
S 24/25 - Avoid contact with skin and eyes.
S 36 - Wear suitable protective clothing.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-rat LD50 5020 mg/kg
Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. Vol. 243, Pg. 609, 1956.

intraperitoneal-mouse LD50 > 2691 mg/kg
Yakugaku Zasshi. Journal of Pharmacy. Vol. 104, Pg. 793, 1984.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: flavor and fragrance agents
Recommendation for para-vanillic acid usage levels up to:
  0.5000 % in the fragrance concentrate.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 24.00 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 26.00 (μg/capita/day)
Structure Class: I
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 20
 average usual ppmaverage maximum ppm
baked goods: --
beverages(nonalcoholic): --
beverages(alcoholic): 5.0000025.00000
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: 5.0000025.00000
egg products: --
fats / oils: --
fish products: --
frozen dairy: 5.0000025.00000
fruit ices: --
gelatins / puddings: --
granulated sugar: --
gravies: --
hard candy: --
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: 3.0000015.00000
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --
 
Safety References:
European Food Safety Athority(efsa):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...
European Food Safety Authority (EFSA) reference(s):
Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the Commission related to Flavouring Group Evaluation 20 (FGE.20): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical group 23
View page or View pdf
Flavouring Group Evaluation 52 (FGE.52): Consideration of hydroxy- and alkoxy-substituted benzyl derivatives evaluated by JECFA (57th meeting) structurally related to benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters evaluated by EFSA in FGE.20 (2005) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf
Flavouring Group Evaluation 54 (FGE.54)[1] - Consideration of benzyl derivatives evaluated by JECFA (57th meeting) structurally related to benzyl alcohols, benzaldehydes, a related acetal, benzoic acids and related esters evaluated by EFSA in FGE.20 (2005) - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food
View page or View pdf
Flavouring Group Evaluation 20, Revision 1 (FGE.20Rev1): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids and related esters from chemical group 23
View page or View pdf
Flavouring Group Evaluation 54, Revision 1 (FGE.54Rev1): Consideration of benzyl derivatives evaluated by JECFA (57th meeting) structurally related to benzyl alcohols, benzaldehydes, a related acetal, benzoic acids and related esters evaluated by EFSA in FGE.20Rev1 (2009)
View page or View pdf
Scientific Opinion on Flavouring Group Evaluation 20, Revision 2 (FGE.20Rev2): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical groups 23 and 30
View page or View pdf
Scientific Opinion on Flavouring Group Evaluation 20, Revision 3(FGE.20Rev3): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical groups 23 and 30
View page or View pdf
EPI System: View
Cancer Citations:Search
Toxicology Citations:Search
Env. Mutagen Info. Center:Search
NLM Developmental and Reproductive Toxicity:Search
EPA Substance Registry Services (TSCA):121-34-6
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :8468
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
4-hydroxy-3-methoxybenzoic acid
Chemidplus:0000121346
RTECS:YM5300000 for cas# 121-34-6
 
References:
 4-hydroxy-3-methoxybenzoic acid
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:121-34-6
Pubchem (cid):8468
Pubchem (sid):134975711
Pherobase:View
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS):View
CHEBI:View
CHEMBL:View
Golm Metabolome Database:Search
Metabolomics Database:Search
UM BBD:Search
KEGG (GenomeNet):C06672
HMDB (The Human Metabolome Database):HMDB00484
FooDB:FDB000846
YMDB (Yeast Metabolome Database):YMDB01802
Export Tariff Code:2918.99.4700
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
RSC Learn Chemistry:View
 
Potential Blenders and core components note
For Odor
acidic
2-
ethyl butyric acid
FL/FR
aldehydic
acetyl nonyryl
FL/FR
anisic
para-
acetanisole
FL/FR
para-
anisaldehyde
FL/FR
balsamic
benzoin resin replacer
FR
peru balsam absolute
FL/FR
peru balsam oil
FL/FR
buttery
acetoin
FL/FR
acetyl butyryl
FL/FR
acetyl isobutyryl
FL/FR
acetyl propionyl
FL/FR
butyl butyryl lactate
FL/FR
caramellic
2-oxo
butyric acid
FL/FR
levulinic acid
FL/FR
strawberry furanone acetate
FL/FR
cheesy
butyric acid
FL/FR
chocolate
chocolate specialty
FR
coconut
coconut decanone methyl
FR
delta-
decalactone
FL/FR
delta-2-
dodecenolactone
FL/FR
delta-
nonalactone
FL/FR
delta-
octalactone
FL/FR
gamma-
octalactone
FL/FR
delta-
undecalactone
FL/FR
creamy
butyl lactate
FL/FR
gamma-
butyrolactone
FL/FR
creamy lactone
FL/FR
3-
heptyl dihydro-5-methyl-2(3H)-furanone
FL/FR
para-
vanillyl alcohol
FL/FR
earthy
1-
nonen-3-ol
FL/FR
fatty
(Z)-
dairy lactone
FL/FR
(Z)-
ethyl oleate
FL/FR
ethyl undecylenate
FL/FR
4-
methyl octanoic acid
FL/FR
fermented
butyl laevo-lactate
FL/FR
floral
heliotropin
FL/FR
hexenyl cyclopentanone
FR
fruity
acetoin acetate
FL/FR
bitter
almond oil
FL/FR
gamma-
decalactone
FL/FR
(R)-delta-
decalactone
FL/FR
farnesyl acetone
FL/FR
methyl (Z)-5-octenoate
FL/FR
(R)-delta-
undecalactone
FL/FR
(S)-delta-
undecalactone
FL/FR
gamma-
undecalactone (aldehyde C-14 (so-called))
FL/FR
green
iso
butyl benzyl carbinol
FL/FR
iso
butyl methyl ketone
FL/FR
(Z)-4-
hepten-1-ol
FL/FR
(Z)-4-
heptenal
FL/FR
(Z)-4-
heptenal diethyl acetal
FL/FR
(E)-2-
hexen-1-yl propionate
FL/FR
ivy dioxolane
FR
milky
laevo-
glutamine
CS
mushroom
3-
octen-2-ol
FL/FR
musk
3-
methyl-6-cyclohexadecen-1-one
FR
omega-
pentadecalactone
FL/FR
powdery
applelide (IFF)
FR
spicy
para-
anisyl formate
FL/FR
dianthus ethone
FR
4-
ethyl guaiacol
FL/FR
sweet
vanilla oleoresin bali
FL/FR
vanilla tahitensis fruit absolute
FR
vanilla tahitensis fruit absolute CO2 extract
FR
vanilla tahitensis fruit oil CO2 extract
FR
tonka
6-
amyl-alpha-pyrone
FL/FR
mint lactone
FL/FR
tropical
3-
nonen-4-olide
FL/FR
vanilla
ortho-
dimethyl hydroquinone
FL/FR
ethyl vanillin
FL/FR
ethyl vanillin isobutyrate
FL/FR
ethyl vanillin propylene glycol acetal
FL/FR
heliotropyl alcohol
FL/FR
propenyl guaethol
FL/FR
vanilla bean absolute (vanilla planifolia)
FL/FR
vanillin
FL/FR
vanillyl acetate
FL/FR
vanillyl isobutyrate
FL/FR
vanillylidene acetone
FL/FR
vegetable
methional
FL/FR
waxy
allyl nonanoate
FL/FR
ethyl palmitate
FL/FR
methyl laurate
FL/FR
nonanoic acid
FL/FR
2-
nonanol
FL/FR
octyl isobutyrate
FL/FR
delta-
tetradecalactone
FL/FR
2-
tridecanone
FL/FR
undecanoic acid
FL/FR
For Flavor
No flavor group found for these
allyl methyl trisulfide
FL
2-
butyl thiophene
FL
(R)-delta-
decalactone
FL/FR
6-
decenoic acid
FL
ortho-
dimethyl hydroquinone
FL/FR
2,5-
dithiahexane
FL
delta-2-
dodecenolactone
FL/FR
farnesyl acetone
FL/FR
heliotropyl alcohol
FL/FR
heptanal 2,3-butane diol acetal
FL
3-
methyl crotonic acid
FL
S-
methyl thiopropionate
FL
3-
nonen-4-olide
FL/FR
(S)-delta-
undecalactone
FL/FR
(R)-delta-
undecalactone
FL/FR
3-(
methyl thio) methyl thiophene
FL
acidic
acidic
2-
ethyl butyric acid
FL/FR
levulinic acid
FL/FR
propionic acid
FL
aldehydic
acetyl nonyryl
FL/FR
amber
iso
butyl benzyl carbinol
FL/FR
anisic
para-
acetanisole
FL/FR
balsamic
peru balsam absolute
FL/FR
peru balsam oil
FL/FR
vanillylidene acetone
FL/FR
brown
2-oxo
butyric acid
FL/FR
buttery
butyl laevo-lactate
FL/FR
diacetyl
FL
cabbage
methyl 2-thiofuroate
FL
caramellic
strawberry furanone acetate
FL/FR
cherry
heliotropin
FL/FR
coconut
delta-
decalactone
FL/FR
massoia bark oil CO2 extract
FL
(R)-
massoia lactone
FL
6-
methyl coumarin
FL
delta-
octalactone
FL/FR
creamy
acetoin
FL/FR
acetyl butyryl
FL/FR
acetyl isobutyryl
FL/FR
6-
amyl-alpha-pyrone
FL/FR
para-
anisaldehyde
FL/FR
butyl butyryl lactate
FL/FR
creamy lactone
FL/FR
divanillin
FL
mint lactone
FL/FR
delta-
nonalactone
FL/FR
octyl isobutyrate
FL/FR
triacetin
FL
delta-
undecalactone
FL/FR
gamma-
undecalactone (aldehyde C-14 (so-called))
FL/FR
para-
vanillyl alcohol
FL/FR
dairy
butyl lactate
FL/FR
methyl (Z)-5-octenoate
FL/FR
earthy
1-
nonen-3-ol
FL/FR
fatty
(Z)-
dairy lactone
FL/FR
(Z)-
ethyl oleate
FL/FR
ethyl undecylenate
FL/FR
4-
methyl octanoic acid
FL/FR
nonanoic acid
FL/FR
2,4-
octadien-1-ol
FL
2-
tridecanone
FL/FR
fruity
acetoin acetate
FL/FR
acetyl isovaleryl
FL
bitter
almond oil
FL/FR
gamma-
decalactone
FL/FR
3-
heptyl dihydro-5-methyl-2(3H)-furanone
FL/FR
green
iso
butyl methyl ketone
FL/FR
(Z)-4-
hepten-1-ol
FL/FR
(Z)-4-
heptenal
FL/FR
(Z)-4-
heptenal diethyl acetal
FL/FR
(E)-2-
hexen-1-yl propionate
FL/FR
lactonic
gamma-
octalactone
FL/FR
milky
gamma-
butyrolactone
FL/FR
dextro,laevo-3-(
methyl thio) butanone
FL
mushroom
3-
octen-2-ol
FL/FR
nutty
furfural acetone
FL
powdery
powdery ketone
FL
sour
butyric acid
FL/FR
spicy
para-
anisyl formate
FL/FR
benzylidene acetone
FL
sweet
vanilla oleoresin bali
FL/FR
toasted
acetyl propionyl
FL/FR
tomato
methional
FL/FR
vanilla
ethyl vanillin
FL/FR
ethyl vanillin isobutyrate
FL/FR
ethyl vanillin propylene glycol acetal
FL/FR
omega-
pentadecalactone
FL/FR
propenyl guaethol
FL/FR
vanilla bean absolute (vanilla planifolia)
FL/FR
vanillin
FL/FR
vanillyl acetate
FL/FR
vanillyl isobutyrate
FL/FR
waxy
allyl nonanoate
FL/FR
ethyl palmitate
FL/FR
methyl laurate
FL/FR
2-
nonanol
FL/FR
octyl 2-furoate
FL
delta-
tetradecalactone
FL/FR
undecanoic acid
FL/FR
woody
4-
ethyl guaiacol
FL/FR
 
Potential Uses:
 chocolate cocoa
FRcoconut
FRcream
FLmilk
FLnut
FRvanilla
 whiskey
 
Occurrence (nature, food, other):note
 apricot fruit
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 arrowroot leaf
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 banana plant
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 barley fruit
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 barley seed
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 beer
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 beet leaf
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 bilberry fruit
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 bilberry fruit juice
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 bilberry leaf
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 blueberry plant
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 brandy
Search PMC Picture
 broccoli asparagus broccoli plant
Search Trop Picture
 buckwheat testa
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 cacao bean
Search Trop Picture
 cardamom leaf
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 carrot tissue culture
Search Trop Picture
 chamomile sweet false chamomile plant
Search Trop Picture
 cherry sour cherry plant
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 chicory
Search Trop Picture
 chicory leaf
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 coconut leaf
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 coriander fruit
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 coriander plant
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 coriander seed
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 corn
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 corn sprout
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 corn tissue culture
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 dandelion flower
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 fennel seed
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 fig wood
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 garlic bulb
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 ginger
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 ginger plant
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 ginkgo biloba leaf
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 ginkgo biloba plant
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 goosefoot fruit
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 grape
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 grape hull husk
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 grape leaf
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 guava fruit
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 horseradish root
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 oat seed
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 olive fruit
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 onion bulb
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 oregano plant
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 pea root
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 pea seed
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 peanut seed
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 poppy opium poppy pericarp
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 raspberry red raspberry plant
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 rhubarb plant
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 rice
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 rice plant
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 rubus spectabilis leaf
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 rum
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 saffron
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 sage
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 sage plant
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 salmonberry leaf
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 sesame leaf
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 sherry
Search PMC Picture
 soybean root
Search Trop Picture
 soybean seed
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 tarragon leaf
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 thyme plant
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 turmeric leaf
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 vanilla
Search Picture
 walnut black walnut nut
Search Trop Picture
 wheat seed
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 whiskey scotch whiskey
Search Picture
 wine red wine
Search Picture
 wine white wine
Search Picture
 
Synonyms:
 acid, p-hydroxy-m-methoxy-benzoic
m-anisic acid, 4-hydroxy-
 benzoic acid, 4-hydroxy-3-methoxy-
4-hydroxy-3-methoxy benzoic acid
4-hydroxy-3-methoxy-benzoic acid
4-hydroxy-3-methoxybenzoate
4-hydroxy-3-methoxybenzoic acid
4-hydroxy-m-anisic acid
p-hydroxy-m-methoxy-benzoic acid
p-hydroxy-m-methoxy-benzonic acid
4-hydroxy-meta-anisic acid
3-methoxy-4-hydroxybenzoic acid
 protocatechuic acid 3-methyl ester
 vanillic acid
p-vanillic acid
 vanillic acid, tech. grade
 vanillicacid
 
 
Notes:
a flavoring agent. it is the intermediate product in the two-step bioconversion of ferulic acid to vanillin. (j biotechnol 1996;50(2-3):107-13). Vanillic acid is a phenolic acid found in some forms of vanilla and many other plant extracts. It is a flavoring and scent agent that produces a pleasant, creamy odor. It is the intermediate product in the two-step bioconversion of ferulic acid to vanillin. (J Biotechnol 1996;50(2-3):107-13). Vanillic acid, which is a chlorogenic acid, is an oxidized form of vanillin. It is also an intermediate in the production of vanillin from ferulic acid. Vanillic acid is a metabolic byproduct of caffeic acid and is often found in the urine of humans who have consumed coffee, chocolate, tea and vanilla-flavored confectionary. Vanillic acid selectively and specifically inhibits 5'nucleotidase activity. (PMID: 16899266)
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