stevioside
steviol glycosides
 
Notes:
kaurene glucoside from leaves of stevia rebaudiana; 300 times as sweet as sugar. Constit. of Stevia rebaudiana (stevia). Sweetening agent which is 300 times sweeter than sucrose. Stevia rebaudiana is extensively cultivated in Japan, and Stevioside is a permitted sweetener in that country Rebaudioside B, D, and E may also be present in minute quantities; however, it is suspected that rebaudioside B is a byproduct of the isolation technique. The two majority compounds stevioside and rebaudioside, primarily responsible for the sweet taste of stevia leaves, were first isolated by two French chemists in 1931.
  • Jiangyin Healthway
    • Jiangyin Healthway International Trade Co.
      Independent Ingredients Supplier
      We provide custom synthesis and contract manufacturing from milligrams to metric tonnes.
      Jiangyin Healthway International Trade Co., Ltd is a professional company, main engaged in manufacturing and exporting aroma chemicals ,food additives , cosmetic ingredient ,pharmaceutical intermediates & other fine chemicals; especially on aroma chemicals , as the major manufacturer of heterocyclic and sulphur aroma compounds , we are the leading independent ingredients supplier to the flavour and fragrance industries in China, can offer hundreds of different high quality aroma chemicals.
      Email: Info
      Email: Sales
      Voice: 86-510-86023169
      Fax: 86-510-86023170
      Mobile0086-13093133011
      Services
      Biochemical
      Natural Food Colour
      New functional food ingredients
      Product(s):
      161177 Stevioside
       
  • O'Laughlin Industries
    • O'Laughlin Industries Inc.
      Manufacturer of Aroma
      Leading the Flavor and Fragrance Industry since 1980.
      O'Laughlin was established in 1980 by its owner and chief executive Michael O'Laughlin, when he moved to Beijing, China and established a small office. Since then it has grown to be a world class producer of chemicals, with significant production facilities in China, and distribution and sales in all major world markets.
      Email: Sales
      US Email: Joe Schreiber
      Voice: (852) 2527-1031
      Fax: (852) 2529-0231
      US Voice: (973) 376-4600
      US Fax: (973) 376-4630
      Product(s):
      775-2022 Stevia 95, Stevia glycoside 95%
       
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CAS Number: 57817-89-7Picture of molecule
ECHA EINECS - REACH Pre-Reg: 260-975-5
FDA UNII: 0YON5MXJ9P
Beilstein Number: 0077427
MDL: MFCD00079561
XlogP3-AA: -1.80 (est)
Molecular Weight: 804.88180000
Formula: C38 H60 O18
BioActivity Summary: listing
Also(can) Contains: rebaudioside A
EFSA/JECFA Comments: Not in Register. Evaluated as a sweetener (ADI of 4 mg/kg bw) as steviol (EFSA, 2010k).
Category: sweeteners, flavor enhancers
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist: Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
 FDA/DG SANTE Petitions, Reviews, Notices:
GRN 395 Steviol glycosides with rebaudioside A and stevioside as the principal components View-notice PDF
GRN 389 Steviol glycosides with stevioside as the principal component View-notice PDF
GRN 367 Purified steviol glycosides with rebaudioside A and stevioside as the principal components View-notice PDF
GRN 349 Purified steviol glycosides with rebaudioside A and stevioside as the principal components View-notice PDF
GRN 348 Stevioside purified from the leaves of Stevia rebaudiana (Bertoni) Bertoni (stevioside) View-notice PDF
GRN 323 Purified steviol glycosides with rebaudioside A and stevioside as the principal components View-notice PDF
GRN 304 Purified steviol glycosides with rebaudioside A and stevioside as the principal components View-notice PDF
GRN 287 Purified steviol glycosides with rebaudioside A and stevioside as the principal components View-notice PDF
GRN 275 Purified steviol glycosides with rebaudioside A as the principal component View-notice PDF
GRN 473 Purified steviol glycosides with rebaudioside X as the principal component View-notice PDF
GRN 493 High purity steviol glycosides (minimum purity 95%) View-notice PDF
GRN 516 Steviol glycosides with rebaudioside A and stevioside as the principal components View-notice PDF
GRN 555 High purity steviol glycosides (minimum purity 95%) consisting primarily of rebaudioside A. View-notice PDF
JECFA Food Additive: Steviol glycosides
GSFA Codex: Steviol glycosides (960)
DG SANTE Food Additives: steviol glycosides
FEMA Number: 4763  stevioside
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Physical Properties:
Appearance: white to pale yellow powder (est)
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Melting Point: 198.00 °C. @ 760.00 mm Hg
Boiling Point: 464.50 °C. @ 760.00 mm Hg (est)
Flash Point: 480.00 °F. TCC ( 248.80 °C. ) (est)
logP (o/w): 4.440 (est)
Soluble in:
 water, 166.9 mg/L @ 25 °C (est)
 water, 1250 mg/L @ 25 °C (exp)
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Organoleptic Properties:
 sweet  
Taste Description:
sweet
  
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: masking agents
oral care agents
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Suppliers:
ADM/Matsutani
Fibersol®-HS
Flavor: sweet
Fibersol®-HS is composed of Fibersol®-2 soluble dietary fiber, honey solids, and purified steviol glycosides, and has been specially designed for applications where replacing liquid honey and sugar to reduce calories and adding fiber are beneficial. Honey provides great taste and flavor. Purified steviol glycosides naturally sweeten without adding calories, and Fibersol®-2 provides water-soluble dietary fiber. The ingredients are converted to a free-flowing powder using a proprietary spray-drying process. Fibersol®-HS contains 78 percent soluble dietary fiber on a dry solids basis. Fibersol®-HS may replace sugar or other 4 kcal per gram sweeteners with up to 70 percent calorie reduction while providing additional fiber, making it an ideal ingredient to use for fiber enhancement, and can provide a “good source” or “excellent source” of fiber claim for food products, assuming all other conditions are met. Fibersol®-HS can be used in baked goods and cereals, snacks and confectionary, beverages, and dairy applications as a convenient replacement for liquid honey and sugar to reduce calories and add fiber.
AIDP
Stevia 90% Steviosides 90% min.
Anhui Haibei
Stevioside
Carbosynth
For experimental / research use only.
Stevioside
ExtraSynthese
For experimental / research use only.
Stevioside (HPLC) ≥98%
Foodchem International
Stevia Powder(Stevia Extract)
Foodchem International
Stevia
Jiangyin Healthway
Stevioside
New functional food ingredients
Nacalai USA
For experimental / research use only.
Stevioside
O'Laughlin Industries
Stevia 95, Stevia glycoside 95%
PureCircle
Stevioside
Sinofi Ingredients
Stevia
Flavor: characteristic
Sugar Substitutes, Chewing Gum, Dairy Products, Confections, Baking Food, Yogurt, Desserts, Beverage Powder, Chai Tea, Gelatins, Puddings, Ice Cream, Cosmetics, Feed, Pharmaceutical.
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: sweeteners, flavor enhancers
Recommendation for stevioside usage levels up to:
 not for fragrance use.
 
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 26
Click here to view publication 26
 average usual ppmaverage maximum ppm
baked goods: 40.0000065.00000
beverages(nonalcoholic): 25.0000035.00000
beverages(alcoholic): 25.0000035.00000
breakfast cereal: 40.0000065.00000
cheese: --
chewing gum: 200.00000200.00000
condiments / relishes: 15.0000030.00000
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: 40.0000055.00000
fruit ices: 25.0000035.00000
gelatins / puddings: 40.0000065.00000
granulated sugar: --
gravies: 15.0000030.00000
hard candy: 40.0000065.00000
imitation dairy: 40.0000065.00000
instant coffee / tea: 25.0000035.00000
jams / jellies: --
meat products: 10.0000020.00000
milk products: 40.0000055.00000
nut products: --
other grains: --
poultry: --
processed fruits: 25.0000035.00000
processed vegetables: 25.0000035.00000
reconstituted vegetables: --
seasonings / flavors: 25.0000035.00000
snack foods: 20.0000030.00000
soft candy: 40.0000065.00000
soups: 10.0000020.00000
sugar substitutes: --
sweet sauces: 25.0000035.00000
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Safety References:
European Food Safety Authority (EFSA) reference(s):
Scientific Opinion on the safety of steviol glycosides for the proposed uses as a food additive
View page or View pdf
Scientific Opinion on Flavouring Group Evaluation 310 (FGE.310): Rebaudioside A from chemical group 30
View page or View pdf
Revised exposure assessment for steviol glycosides for the proposed uses as a food additive
View page or View pdf
Scientific Opinion on the revised exposure assessment of steviol glycosides (E 960) for the proposed uses as a food additive
View page or View pdf
Scientific opinion on the safety of the extension of use of steviol glycosides (E 960) as a food additive
View page or View pdf
Scientific opinion on the safety of the proposed amendment of the specifications for steviol glycosides (E 960) as a food additive
View page or View pdf
EPI System: View
ClinicalTrials.gov: search
Chemical Carcinogenesis Research Information System: Search
Cancer Citations: Search
Toxicology Citations: Search
Carcinogenic Potency Database: Search
EPA GENetic TOXicology: Search
Env. Mutagen Info. Center: Search
NLM Developmental and Reproductive Toxicity: Search
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 42576
National Institute of Allergy and Infectious Diseases: Data
Chemidplus: 0057817897
RTECS: NZ8175000 for cas# 57817-89-7
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References:
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 42576
Pubchem (sid): 135004008
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
KEGG (GenomeNet): C09189
HMDB (The Human Metabolome Database): HMDB34945
FooDB: FDB013538
Export Tariff Code: 2938.90.0000
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
Read: Under the conditions of intended use - New developments in the FEMA GRAS program and the safety assessment of flavor ingredients
Read: A GRAS assessment program for flavor ingredients
Read: Sensory testing for flavorings with modifying properties. Food Technology
Read: Criteria for the safety evaluation of flavoring substances
Read: A procedure for the safety evaluation of natural flavor complexes used as ingredients in food: essential oils
Read: FEMA Expert Panel: 30 Years of safety evaluation for the flavor industry
Read: Consumption ratio and food predominance of flavoring materials
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 stevia rebaudiana
Search Trop  Picture
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Synonyms:
 steviol glycoside
 steviol glycosides
 steviosin
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Articles:
Google Patents: Composition and process for modifying or enhancing flavors
PubMed: Large-scale profiling of diterpenoid glycosides from Stevia rebaudiana using ultrahigh performance liquid chromatography/tandem mass spectrometry.
Google Patents: Glucosylated steviol glycoside as a flavor modifier
PubMed: Tandem mass spectrometric fragmentation patterns of known and new steviol glycosides with structure proposals.
PubMed: Stevioside inhibits inflammation and apoptosis by regulating TLR2 and TLR2-related proteins in S. aureus-infected mouse mammary epithelial cells.
PubMed: Synergistic Foaming and Surface Properties of a Weakly Interacting Mixture of Soy Glycinin and Biosurfactant Stevioside.
PubMed: High-performance thin-layer chromatography analysis of steviol glycosides in Stevia formulations and sugar-free food products, and benchmarking with (ultra) high-performance liquid chromatography.
PubMed: Transglycosylation specificity of glycosyl donors in transglycosylation of stevioside catalysed by cyclodextrin glucanotransferase.
PubMed: Adsorption characteristics of rebaudioside A and stevioside on cross-linked poly(styrene-co-divinylbenzene) macroporous resins functionalized with chloromethyl, amino and phenylboronic acid groups.
PubMed: Genetic signature of differential sensitivity to stevioside in the Italian population.
PubMed: Use of just-about-right scales and penalty analysis to determine appropriate concentrations of stevia sweeteners for vanilla yogurt.
PubMed: Fast methodology of analysing major steviol glycosides from Stevia rebaudiana leaves.
PubMed: Methylerythritol and mevalonate pathway contributions to biosynthesis of mono-, sesqui-, and diterpenes in glandular trichomes and leaves of Stevia rebaudiana Bertoni.
PubMed: Development and validation of a reversed-phase high-performance liquid chromatography method for routine identification and purity assessment of high-purity steviol glycoside sweeteners.
PubMed: Steviol glucuronidation and its potential interaction with UDP-glucuronosyltransferase 2B7 substrates.
PubMed: Use of the modified Gompertz equation to assess the Stevia rebaudiana Bertoni antilisterial kinetics.
PubMed: The influence of stevia glycosides on the growth of Lactobacillus reuteri strains.
PubMed: Utilisation of steviol glycosides from Stevia rebaudiana (Bertoni) by lactobacilli and bifidobacteria in in vitro conditions.
PubMed: Efficient regeneration for enhanced steviol glycosides production in Stevia rebaudiana (Bertoni).
PubMed: Quantitation of sweet steviol glycosides by means of a HILIC-MS/MS-SIDA approach.
PubMed: Biotransformation of stevioside by Leuconostoc citreum SK24.002 alternansucrase acceptor reaction.
PubMed: Classification of stevia sweeteners in soft drinks using liquid chromatography and time-of-flight mass spectrometry.
PubMed: Ecotoxicity of artificial sweeteners and stevioside.
PubMed: [The use of low-calorie sweeteners].
PubMed: [Simultaneous determination of twelve sweeteners and nine preservatives in foods by solid-phase extraction and LC-MS/MS].
PubMed: Assessment of Korean consumer exposure to sodium saccharin, aspartame and stevioside.
PubMed: Determination of six steviol glycosides of Stevia rebaudiana (Bertoni) from different geographical origin by LC-ESI-MS/MS.
PubMed: Anti-inflammatory and immunomodulatory activities of stevioside and steviol on colonic epithelial cells.
PubMed: Effects of salt stress on the growth, physiological responses, and glycoside contents of Stevia rebaudiana Bertoni.
PubMed: Enhanced physical and oxidative stabilities of soy protein-based emulsions by incorporation of a water-soluble stevioside-resveratrol complex.
PubMed: Genetic and metabolic diversity in Stevia rebaudiana using RAPD and HPTLC analysis.
PubMed: Simultaneous analysis of steviol and steviol glycosides by liquid chromatography with ultraviolet detection on a mixed-mode column: application to Stevia plant material and Stevia-containing dietary supplements.
PubMed: Transglycosylation of stevioside to improve the edulcorant quality by lower substitution using cornstarch hydrolyzate and CGTase.
PubMed: Sweeteners from plants--with emphasis on Stevia rebaudiana (Bertoni) and Siraitia grosvenorii (Swingle).
PubMed: Stevia rebaudiana Bertoni as a source of bioactive compounds: the effect of harvest time, experimental site and crop age on steviol glycoside content and antioxidant properties.
PubMed: Absolute quantitation of stevioside and rebaudioside A in commercial standards by quantitative NMR.
PubMed: Steviol glycoside safety: is the genotoxicity database sufficient?
PubMed: Analysis of nine food additives in red wine by ion-suppression reversed-phase high-performance liquid chromatography using trifluoroacetic acid and ammonium acetate as ion-suppressors.
PubMed: Simultaneous determination of steviol and steviol glycosides by liquid chromatography-mass spectrometry.
PubMed: Application of dispersive solid-phase extraction and ultra-fast liquid chromatography-tandem quadrupole mass spectrometry in food additive residue analysis of red wine.
PubMed: Stability of steviol glycosides in several food matrices.
PubMed: "Extraction and safety of stevioside"; response to the article "Stevia rebaudiana Bertoni, source of a high potency natural sweetener: a comprehensive review on the biochemical, nutritional and functional aspects".
PubMed: Steviol glycosides from Stevia: biosynthesis pathway review and their application in foods and medicine.
PubMed: Human psychometric and taste receptor responses to steviol glycosides.
PubMed: Mass production of rubusoside using a novel stevioside-specific β-glucosidase from Aspergillus aculeatus.
PubMed: Stevioside enhances satellite cell activation by inhibiting of NF-κB signaling pathway in regenerating muscle after cardiotoxin-induced injury.
PubMed: [Influences of ion-suppressors on retention behaviors of nine food additives in reversed-phase high performance liquid chromatographic separation].
PubMed: The leaves of Stevia rebaudiana (Bertoni), their constituents and the analyses thereof: a review.
PubMed: Functional food and diabetes: a natural way in diabetes prevention?
PubMed: Synthesis of ent-kaurane diterpene monoglycosides.
PubMed: Enzyme-assisted extraction of bioactives from plants.
PubMed: Preparative separation and purification of rebaudioside a from steviol glycosides using mixed-mode macroporous adsorption resins.
PubMed: Downstream processing of stevioside and its potential applications.
PubMed: Evaluation of certain food additive and contaminants.
PubMed: Tandem mass spectrometric fragmentation patterns of known and new steviol glycosides with structure proposals.
PubMed: Identification and quantification of major steviol glycosides in Stevia rebaudiana purified extracts by 1H NMR spectroscopy.
PubMed: Long-term feeding effects of stevioside sweetener on some toxicological parameters of growing male rats.
PubMed: Investigations on the stability of stevioside and rebaudioside a in soft drinks.
PubMed: The food additives inulin and stevioside counteract oxidative stress.
PubMed: Employing ultra high pressure liquid chromatography as the second dimension in a comprehensive two-dimensional system for analysis of Stevia rebaudiana extracts.
PubMed: Stevia and saccharin preferences in rats and mice.
PubMed: Evaluation of certain food additives.
PubMed: Stevioside inhibits atherosclerosis by improving insulin signaling and antioxidant defense in obese insulin-resistant mice.
PubMed: Stevia (Stevia rebaudiana) a bio-sweetener: a review.
PubMed: Stimulatory effect of stevioside on peripheral mu opioid receptors in animals.
PubMed: Simultaneous determination of nonnutritive sweeteners in foods by HPLC/ESI-MS.
PubMed: Photostability of rebaudioside A and stevioside in beverages.
PubMed: Comparative toxicokinetics and metabolism of rebaudioside A, stevioside, and steviol in rats.
PubMed: A critical review of the genetic toxicity of steviol and steviol glycosides.
PubMed: Pharmacokinetics of rebaudioside A and stevioside after single oral doses in healthy men.
PubMed: Overview: the history, technical function and safety of rebaudioside A, a naturally occurring steviol glycoside, for use in food and beverages.
PubMed: The hemodynamic effects of rebaudioside A in healthy adults with normal and low-normal blood pressure.
PubMed: Evaluation of certain food additives and contaminants.
PubMed: Microbial hydrolysis of steviol glycosides.
PubMed: The use of a sweetener substitution method to predict dietary exposures for the intense sweetener rebaudioside A.
PubMed: Specific immunomodulatory and secretory activities of stevioside and steviol in intestinal cells.
PubMed: Immune up regulatory response of a non-caloric natural sweetener, stevioside.
PubMed: Re: Analysis of genotoxic potentiality of stevioside by comet assay.
PubMed: Comments to the paper by Nunes et al. (2007), Analysis of genotoxic potentiality of stevioside by comet assay, Food and Chemical Toxicology 45 (2007) 662-666.
PubMed: The diterpene glycoside, rebaudioside A, does not improve glycemic control or affect blood pressure after eight weeks treatment in the Goto-Kakizaki rat.
PubMed: Steviol glycoside biosynthesis.
PubMed: Analysis of genotoxic potentiality of stevioside by comet assay.
PubMed: Biological effects of stevioside on the survival of Escherichia coli strains and plasmid DNA.
PubMed: Spatial organisation of four enzymes from Stevia rebaudiana that are involved in steviol glycoside synthesis.
PubMed: Identification of steviol glucuronide in human urine.
PubMed: Anti-Inflammatory and Immunomodulatory Activities of Stevioside and Its Metabolite Steviol on THP-1 Cells.
PubMed: Daily intake assessment of saccharin, stevioside, D-sorbitol and aspartame from various processed foods in Korea.
PubMed: Increase of insulin sensitivity by stevioside in fructose-rich chow-fed rats.
PubMed: Evaluation of certain food additives.
PubMed: Preventive effects of a soy-based diet supplemented with stevioside on the development of the metabolic syndrome and type 2 diabetes in Zucker diabetic fatty rats.
PubMed: [Analysis of nine kinds of sweeteners in foods by LC/MS].
PubMed: Structural analysis of isosteviol and related compounds as DNA polymerase and DNA topoisomerase inhibitors.
PubMed: Functional genomics uncovers three glucosyltransferases involved in the synthesis of the major sweet glucosides of Stevia rebaudiana.
PubMed: [Simultaneous determination of stevioside, rebaudioside A and glycyrrhizic acid in foods by HPLC].
PubMed: Steviol quantification at the picomole level by high-performance liquid chromatography.
PubMed: Antihyperglycemic effects of stevioside in type 2 diabetic subjects.
PubMed: Stevioside.
PubMed: Metabolism of stevioside and rebaudioside A from Stevia rebaudiana extracts by human microflora.
PubMed: Metabolism of stevioside in pigs and intestinal absorption characteristics of stevioside, rebaudioside A and steviol.
PubMed: Effect of stevioside and steviol on the developing broiler embryos.
PubMed: Metabolism of stevioside by chickens.
PubMed: In vitro metabolism of the glycosidic sweeteners, stevia mixture and enzymatically modified stevia in human intestinal microflora.
PubMed: Leaf Ests from Stevia rebaudiana: a resource for gene discovery in diterpene synthesis.
PubMed: Analysis of sweet diterpene glycosides from Stevia rebaudiana: improved HPLC method.
PubMed: Evaluation of certain food additives. Fifty-first report of the Joint FAO/WHO Expert Committee on Food Additives.
PubMed: Measurement of the relative sweetness of stevia extract, aspartame and cyclamate/saccharin blend as compared to sucrose at different concentrations.
PubMed: Assessment of the carcinogenicity of stevioside in F344 rats.
PubMed: Pharmacokinetic studies of 131I-stevioside and its metabolites.
PubMed: Chronic oral toxicity and carcinogenicity study of stevioside in rats.
PubMed: Evaluation of the cariogenic potential of the intense natural sweeteners stevioside and rebaudioside A.
PubMed: [Subchronic oral toxicity study of stevioside in F344 rats].
PubMed: Determination of seven artificial sweeteners in diet food preparations by reverse-phase liquid chromatography with absorbance detection.
PubMed: Diterpenoid sweeteners. Synthesis and sensory evaluation of stevioside analogues with improved organoleptic properties.
PubMed: Drugs, food additives and natural products as promoters in rat urinary bladder carcinogenesis.
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