glycyrrhizic acid
glycyrrhetinic acid glycoside
 
Notes:
a widely used anti-inflammatory agent isolated from the licorice root. it is metabolized to glycyrrhetinic acid, which inhibits 11-beta-hydroxysteroid dehydrogenases and other enzymes involved in the metabolism of corticosteroids. therefore, glycyrrhizic acid, which is the main and sweet component of licorice, has been investigated for its ability to cause hypermineralocorticoidism with sodium retention and potassium loss, edema, increased blood pressure, as well as depression of the renin-angiotensin-aldosterone system. Isol. from Glycyrrhiza glabra (liquorice). Nutriceutical with anticancer props. Glycyrrhizic acid is a triterpenoid saponin glycoside of glycyrrhetinic acid. It is the main sweet-tasting compound from liquorice root. It is 3050 times as sweet as sucrose. (Wikipedia)
  • Jiangyin Healthway
    • Jiangyin Healthway International Trade Co.
      Independent Ingredients Supplier
      We provide custom synthesis and contract manufacturing from milligrams to metric tonnes.
      Jiangyin Healthway International Trade Co., Ltd is a professional company, main engaged in manufacturing and exporting aroma chemicals ,food additives , cosmetic ingredient ,pharmaceutical intermediates & other fine chemicals; especially on aroma chemicals , as the major manufacturer of heterocyclic and sulphur aroma compounds , we are the leading independent ingredients supplier to the flavour and fragrance industries in China, can offer hundreds of different high quality aroma chemicals.
      Email: Info
      Email: Sales
      Voice: 86-510-86023169
      Fax: 86-510-86023170
      Mobile0086-13093133011
      Services
      Biochemical
      Natural Food Colour
      New functional food ingredients
      Product(s):
      HLC-303 Glycyrrhizic Acid
       
  • Penta International
    • Penta International Corporation
      Chemistry innovation
      At Penta, our products and services help businesses do business better.
      For over 30 years, Penta Manufacturing Company has played a growing role in worldwide chemistry innovations and applications. As an industry leader, Penta continues to pioneer chemistry-based solutions for practically every area of commerce. Our products and expertise have helped fuel technical advances in dozens of commercial applications including flavoring, coloring, fragrances and chemical processes.
      US Email: Technical Services
      US Email: Sales
      US Voice: (973) 740-2300
      US Fax: (973) 740-1839
      Product(s):
      07-41000 GLYCYRRHIZIC ACID, Kosher
      07-41020 GLYCYRRHIZIC ACID, NATURAL, Kosher
       
  • TCI AMERICA
    • TCI AMERICA
      Moving Your Chemistry Forward
      We continuously strive to advance our technology.
      Tokyo Chemical Industry Co., Ltd. (TCI) is a leading worldwide manufacturer of specialty organic chemicals founded in 1946. TCI provides organic laboratory chemicals as well as pharmaceutical, cosmetic and functional materials. More than 60 years of synthesis experience and multi-purpose plants enable TCI to offer more than 27,000 products as well as custom synthesis. TCI established overseas facilities in North America, Europe, China and India to serve customers worldwide.
      Email: Sales
      US Email: Sales
      Email: Global Business
      Voice: +81-3-5640-8878
      Fax: +81-3-5640-8902
      US Voice: 800-423-8616
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      Tokyo Tel:03-5640-8851
      Tokyo Fax:03-5640-8865
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      Product(s):
      G0150 Glycyrrhizin >93.0%(T)
       
Synonyms   Articles   Notes   Search
(2S,3S,4S,5R,6R)-6-[(2S,3R,4S,5S,6S)-2-[[(3S,4aR,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-carboxy-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14 (Click)
CAS Number: 1405-86-3Picture of molecule
ECHA EINECS - REACH Pre-Reg: 215-785-7
FDA UNII: 6FO62043WK
Nikkaji Web: J1.238F
Beilstein Number: 0077922
CoE Number: 2221
XlogP3-AA: 3.70 (est)
Molecular Weight: 822.94334000
Formula: C42 H62 O16
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: cosmetic and flavor agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist: Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
 FDA/DG SANTE Petitions, Reviews, Notices:
184.1408 Licorice, Glycyrrhiza, and Ammoniated Glycyrrhizin View-review
Flavis Number: 16.012 (Old)
DG SANTE Food Flavourings: 16.012  glycyrrhizic acid
Synonyms   Articles   Notes   Search   Top
Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Melting Point: 200.00 to  214.00 °C. @ 760.00 mm Hg
Boiling Point: 970.00 to  972.00 °C. @ 760.00 mm Hg
Flash Point: 550.00 °F. TCC ( 287.78 °C. )
logP (o/w): 2.800
Soluble in:
 alcohol
 water, 0.05298 mg/L @ 25 °C (est)
Insoluble in:
 water
Synonyms   Articles   Notes   Search   Top
Organoleptic Properties:
Odor Type: spicy
Odor Strength: low
Odor Description:
at 100.00 %. 
mild spicy
 sweet  
Taste Description:
sweet
  
Synonyms   Articles   Notes   Search   Top
Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: humectants
skin conditioning
Synonyms   Articles   Notes   Search   Top
Suppliers:
Anhui Haibei
Glycyrrhizin
Changsha Organic Herb
Licorice Root Extract
Coompo
For experimental / research use only.
Glycyrrhizic Acid from Plants ≥98%
Odor: characteristic
Use: Glycyrrhizie acid is active against viruses. It inhibits growth and cytopathology of several unrelated DNA and RNA viruses, while not affecting cell activity and ability to replicate. In addition, glycyrrhizic acid inactivates herpes simplex virus particles irreversibly. Glycyrrhizie acid was shown to inhibit SARS-coronavirus (SARS-CoV) replication in vitro. Amides of GL and conjugates of GL with two amino acid residues and a free 30-COOH function presented up to 70-fold increased activity against SARS-CoV but also increased cytotoxicity resulting in decreased selectivity index.
Jiangyin Healthway
Glycyrrhizic Acid
New functional food ingredients
Nacalai USA
For experimental / research use only.
Glycyrrhizin
Penta International
GLYCYRRHIZIC ACID, Kosher
Penta International
GLYCYRRHIZIC ACID, NATURAL, Kosher
Santa Cruz Biotechnology
For experimental / research use only.
Glycyrrhizic Acid ≥93%
Sigma-Aldrich
For experimental / research use only.
Glycyrrhizic Acid Pharmaceutical Secondary Standard; Certified Reference Material
TCI AMERICA
For experimental / research use only.
Glycyrrhizin >93.0%(T)
Universal Preserv-A-Chem Inc.
GLYCYRRHIZIC ACID
Odor: characteristic
Use: Has the function of andti-bacterial and anti-tumor properties. Plays a part in the adrenal cortical hormone, which is used to treat rheumatoid arthritis, asthma, allergic dermatitis inflammation of ENT and ulceration. Is a food sweetener, flavoring agent, also used in cosmetics and medicine.
Synonyms   Articles   Notes   Search   Top
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-human TDLo  5571 ug/kg/3D-
KIDNEY, URETER, AND BLADDER: OTHER CHANGES IN URINE COMPOSITION
Toxicologist. Vol. 54, Pg. 109, 2000.

oral-human TDLo  280 mg/kg/4W
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
British Medical Journal. Vol. 1, Pg. 488, 1977.

oral-man TDLo  662 mg/kg/1Y-I
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: MUSCLE WEAKNESS
Internal Medicine. Vol. 31, Pg. 708, 1992.

intravenous-mouse LD50  589 mg/kg
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. Vol. 28, Pg. 215, 1993.

oral-mouse LD50  4320 mg/kg
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. Vol. 28, Pg. 215, 1993.

intraperitoneal-mouse LDLo  1000 mg/kg
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 5, Pg. 2041, 1977.

intravenous-rat LD  > 300 mg/kg
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 5, Pg. 2041, 1977.

intraperitoneal-rat LDLo  2000 mg/kg
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 5, Pg. 2041, 1977.

oral-rat LDLo  3000 mg/kg
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 5, Pg. 2041, 1977.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Synonyms   Articles   Notes   Search   Top
Safety in Use Information:
Category: cosmetic and flavor agents
Recommendation for glycyrrhizic acid usage levels up to:
 not for fragrance use.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 240.00 (μg/capita/day)
Modified Theoretical Added Maximum Daily Intake (mTAMDI): 210000 (μg/person/day)
Threshold of Concern:90 (μg/person/day)
Structure Class: III
 
Food categories according to Commission Regulation EC No. 1565/2000 (EC, 2000) in FGE.06 (EFSA, 2002a). According to the Industry the "normal" use is defined as the average of reported usages and "maximum use" is defined as the 95th percentile of reported usages (EFSA, 2002i).
Note: mg/kg = 0.001/1000 = 0.000001 = 1/1000000 = ppm.
 average usage mg/kgmaximum usage mg/kg
Dairy products, excluding products of category 02.0 (01.0): 375.00000-
Fats and oils, and fat emulsions (type water-in-oil) (02.0): --
Edible ices, including sherbet and sorbet (03.0): 375.00000-
Processed fruit (04.1): --
Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2): --
Confectionery (05.0): 5000.00000-
Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0): --
Bakery wares (07.0): 200.00000-
Meat and meat products, including poultry and game (08.0): 25.00000-
Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0): 20.00000-
Eggs and egg products (10.0): --
Sweeteners, including honey (11.0): --
Salts, spices, soups, sauces, salads, protein products, etc. (12.0): --
Foodstuffs intended for particular nutritional uses (13.0): --
Non-alcoholic ("soft") beverages, excl. dairy products (14.1): 50.00000-
Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2): 550.00000-
Ready-to-eat savouries (15.0): --
Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0): 10.00000-
Synonyms   Articles   Notes   Search   Top
Safety References:
European Food Safety Athority(efsa): Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...
European Food Safety Authority (EFSA) reference(s):
Flavouring Group Evaluation 29 (FGE29)[1] - Substance from the priority list: Vinylbenzene from chemical group 31 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC)
View page or View pdf
Flavouring Group Evaluation 36, (FGE.36) - Two triterpene glycosides from the priority list - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC)
View page or View pdf
Scientific Opinion on Flavouring Group Evaluation 49, Revision 1 (FGE.49Rev1): xanthine alkaloids from the priority list
View page or View pdf
EPI System: View
ClinicalTrials.gov: search
NLM Hazardous Substances Data Bank: Search
Chemical Carcinogenesis Research Information System: Search
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
Env. Mutagen Info. Center: Search
EPA Substance Registry Services (TSCA): 1405-86-3
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 14982
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 2
 (2S,3S,4S,5R,6R)-6-[(2S,3R,4S,5S,6S)-2-[[(3S,4aR,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-carboxy-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14
Chemidplus: 0001405863
RTECS: MD2025000 for cas# 1405-86-3
Synonyms   Articles   Notes   Search   Top
References:
 (2S,3S,4S,5R,6R)-6-[(2S,3R,4S,5S,6S)-2-[[(3S,4aR,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-carboxy-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 1405-86-3
Pubchem (cid): 14982
Pubchem (sid): 134981322
Synonyms   Articles   Notes   Search   Top
Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
CHEBI: View
CHEMBL: View
KEGG (GenomeNet): C02284
HMDB (The Human Metabolome Database): HMDB29843
FooDB: FDB001060
Export Tariff Code: 2938.90.0000
Haz-Map: View
Household Products: Search
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
Read: Under the conditions of intended use - New developments in the FEMA GRAS program and the safety assessment of flavor ingredients
Read: A GRAS assessment program for flavor ingredients
Read: Sensory testing for flavorings with modifying properties. Food Technology
Read: Criteria for the safety evaluation of flavoring substances
Read: A procedure for the safety evaluation of natural flavor complexes used as ingredients in food: essential oils
Read: FEMA Expert Panel: 30 Years of safety evaluation for the flavor industry
Read: Consumption ratio and food predominance of flavoring materials
Formulations/Preparations:
•for improved water solubility, an ammoniated salt is commonly used. either ammonium glycyrrhizinate or monoammonium glycyrrhizinate. •...main constituent of licorice is glycyrrhizin (the potassium-calcium-magnesium salt of glycyrrhizic acid); commercial glycyrrhizin is ammonium salt of the acid.
Synonyms   Articles   Notes   Search   Top
Potential Blenders and core components note
 
For Odor
alcoholic
alcoholic
 fusel oilFL/FR
animal
 methyl (E)-2-octenoateFL/FR
anise
star anise seed oil terpenelessFL/FR
anisic
para-acetanisoleFL/FR
 ethyl para-anisateFL/FR
balsamic
 benzyl salicylateFL/FR
 ethyl cinnamateFL/FR
dextro-fenchoneFL/FR
 guaiacyl phenyl acetateFL/FR
 hexyl benzoateFL/FR
bready
 furfuralFL/FR
buttery
 acetoinFL/FR
 caramel furanone solutionFL/FR
 caramel pentadioneFL/FR
 coffee dioneFL/FR
 cycloteneFL/FR
 cyclotene hydrateFL/FR
 ethyl cyclopentenoloneFL/FR
 ethyl furaneolFL/FR
 ethyl maltolFL/FR
 levulinic acidFL/FR
 maltolFL/FR
 maltyl isobutyrateFL/FR
 maltyl propionateFL/FR
 maple furanoneFL/FR
5-methyl furfuralFL/FR
 shoyu furanoneFL/FR
 strawberry furanoneFL/FR
 strawberry furanone acetateFL/FR
 strawberry furanone solutionFL/FR
cheesy
isovaleric acidFL/FR
chemical
isobutyl formateFL/FR
 propyl propionateFL/FR
chocolate
isoamyl phenyl acetateFL/FR
 cocoa pentenalFL/FR
citrus
2-ethyl-1-hexanolFL/FR
 lime essence oilFL/FR
dextro-limoneneFL/FR
alpha-terpinyl methyl etherFL/FR
delta-octalactoneFL/FR
creamy
3-heptyl dihydro-5-methyl-2(3H)-furanoneFL/FR
para-vanillic acidFL/FR
para-vanillyl alcoholFL/FR
 veratraldehydeFL/FR
dry
3,4-xylenolFL/FR
earthy
 methyl 3-hexenoateFL/FR
ethereal
 ethyl acetateFL/FR
 ethyl formateFL/FR
 ethyl pyruvateFL/FR
isopropyl formateFL/FR
fatty
(E)-2-octenalFL/FR
(E,Z,Z)-2,4,7-tridecatrienalFL/FR
floral
 acetophenoneFL/FR
 benzyl acetateFL/FR
 benzyl isobutyrateFL/FR
 citronellyl anthranilateFL/FR
 citronellyl phenyl acetateFL/FR
 ethyl phenyl acetateFL/FR
 geranyl isobutyrateFL/FR
 heliotropyl acetoneFL/FR
(Z)-3-hexen-1-yl salicylateFL/FR
alpha-hexyl cinnamaldehydeFL/FR
 hexyl lactateFL/FR
 hydroxycitronellalFL/FR
 hydroxycitronellolFL/FR
alpha-ionolFL/FR
para-methyl acetophenoneFL/FR
beta-naphthyl methyl ketoneFL/FR
 nonanolFL/FR
 phenethyl alcoholFL/FR
 phenethyl propionateFL/FR
4-phenyl-3-buten-2-olFL/FR
isopropyl phenyl acetateFL/FR
 rhodinyl phenyl acetateFL/FR
 rose butanoateFL/FR
 rose oil (rosa damascena) russiaFL/FR
 rose oil (rosa damascena) turkeyFL/FR
 terpinyl valerateFL/FR
 tuberose absolute (from pommade)FL/FR
fruity
 allyl hexanoateFL/FR
isobutyl 2-butenoateFL/FR
isobutyl acetoacetateFL/FR
isobutyl anthranilateFL/FR
isobutyl butyrateFL/FR
 butyl butyrateFL/FR
isobutyl isovalerateFL/FR
 butyl isovalerateFL/FR
 ethyl 3-(2-furyl) propanoateFL/FR
 ethyl 3-hexenoateFL/FR
 ethyl 3-hydroxyhexanoateFL/FR
 ethyl benzoyl acetateFL/FR
 ethyl butyrateFL/FR
 ethyl isovalerateFL/FR
 ethyl lactateFL/FR
 ethyl methyl-para-tolyl glycidateFL/FR
 ethyl propionateFL/FR
(E,E)-ethyl sorbateFL/FR
 ethyl valerateFL/FR
2-hexen-1-olFL/FR
 hexyl acetateFL/FR
 linalyl isobutyrateFL/FR
 menthyl isovalerateFL/FR
 methyl 3-nonenoateFL/FR
 methyl anthranilateFL/FR
2-methyl butyl acetateFL/FR
 methyl heptanoateFL/FR
 methyl isobutyrateFL/FR
 methyl valerateFL/FR
 neryl isobutyrateFL/FR
 octyl butyrateFL/FR
 octyl propionateFL/FR
2-pentanoneFL/FR
 pineapple hydroxyhexanoateFL/FR
 prenyl acetateFL/FR
isopropyl 2-methyl butyrateFL/FR
isopropyl butyrateFL/FR
 propyl butyrateFL/FR
 propyl heptanoateFL/FR
 propyl hexanoateFL/FR
 propyl isobutyrateFL/FR
isopropyl octanoateFL/FR
 strawberry glycidate 1 (aldehyde C-16 (so-called))FL/FR
 strawberry glycidate 2FL/FR
 tetrahydrofurfuryl acetateFL/FR
para-tolualdehydeFL/FR
 tolualdehydes (mixed o,m,p)FL/FR
 tropical iononeFL/FR
 vanilla carboxylateFL/FR
green
 cucumber essenceFL/FR
(Z)-4-hepten-1-olFL/FR
 hexyl isobutyrateFL/FR
 hexyl phenyl acetateFL/FR
(E,Z)-3,6-nonadien-1-yl acetateFL/FR
(E)-2-octen-1-olFL/FR
2-octen-1-olFL/FR
 phenethyl tiglateFL/FR
 terpinyl propionateFL/FR
herbal
 anethum graveolens herb tinctureFL/FR
 clary sage absoluteFL/FR
 linalyl isovalerateFL/FR
 linalyl octanoateFL/FR
 lovage tinctureFL/FR
 perillaldehydeFL/FR
3-propylidene phthalideFL/FR
honey
 methyl phenyl acetateFL/FR
 propyl phenyl acetateFL/FR
licorice
(E)-anetholFL/FR
medicinal
2,6-xylenolFL/FR
minty
 ethyl benzoateFL/FR
 ethyl salicylateFL/FR
 methyl salicylateFL/FR
 peppermint oil americaFL/FR
 peppermint oil idahoFL/FR
musk
 ethylene brassylateFL/FR
musty
ketoisophoroneFL/FR
isobutyl angelateFL/FR
4-ethyl guaiacolFL/FR
 eugenolFL/FR
isoeugenolFL/FR
isoeugenyl acetateFL/FR
isoeugenyl phenyl acetateFL/FR
para-methoxycinnamaldehydeFL/FR
alpha-methyl cinnamaldehydeFL/FR
 methyl heptadienoneFL/FR
alpha-methyl-(E)-cinnamaldehydeFL/FR
(E)-propyl 2-furan acrylateFL/FR
(E)-tiglic acidFL/FR
 vanilla bean absolute (vanilla planifolia)FL/FR
 vanilla bean absolute (vanilla spp.)FL/FR
 vanilla oleoresin baliFL/FR
 vanilla oleoresin bourbonFL/FR
 vanilla resinoidFL/FR
 vanilla tahitensis fruit extractFL/FR
tonka
 mint lactoneFL/FR
 octahydrocoumarinFL/FR
tropical
 genet absoluteFL/FR
 ethyl vanillinFL/FR
 ethyl vanillin propylene glycol acetalFL/FR
 propenyl guaetholFL/FR
 vanilla aromatica fruit extractFL/FR
 vanillinFL/FR
 vanillin propylene glycol acetalFL/FR
 vanillyl acetateFL/FR
 vanillyl isobutyrateFL/FR
 vanillylidene acetoneFL/FR
waxy
 ethyl decanoateFL/FR
 ethyl myristateFL/FR
 ethyl octanoateFL/FR
 nonanoic acidFL/FR
1-undecanolFL/FR
woody
2-methoxy-4-vinyl phenolFL/FR
 
For Flavor
 
acidic
(E)-2-hexenoic acidFL
 levulinic acidFL/FR
aldehydic
 nonanolFL/FR
1-undecanolFL/FR
anise
(E)-anetholFL/FR
star anise seed oil terpenelessFL/FR
 ethyl para-anisateFL/FR
anisic
para-acetanisoleFL/FR
balsamic
 benzyl salicylateFL/FR
 ethyl cinnamateFL/FR
 vanillylidene acetoneFL/FR
berry
 heliotropyl acetoneFL/FR
bitter
(E,Z,Z)-2,4,7-tridecatrienalFL/FR
brown
 furfuralFL/FR
5-methyl furfuralFL/FR
 tetrahydrofurfuryl acetateFL/FR
(E)-tiglic acidFL/FR
burnt
 furfuryl alcoholFL
2,6-xylenolFL/FR
caramellic
 caramel furanoneFL
 caramel furanone solutionFL/FR
 caramel pentadioneFL/FR
 cycloteneFL/FR
 cyclotene hydrateFL/FR
 ethyl furaneolFL/FR
 ethyl maltolFL/FR
 lucuma flavorFL
 maltolFL/FR
 maltyl propionateFL/FR
 maple distillatesFL
 maple furanoneFL/FR
3-methyl butyl 2-furyl butyrateFL
 pyruvaldehydeFL
 shoyu furanoneFL/FR
 strawberry furanoneFL/FR
 strawberry furanone acetateFL/FR
 strawberry furanone solutionFL/FR
cheesy
 ammonium isovalerate 30% in pgFL
isovaleric acidFL/FR
cherry
para-methoxycinnamaldehydeFL/FR
chocolate
bittersweet chocolate flavorFL
citrus
 lime essence oilFL/FR
dextro-limoneneFL/FR
beta-naphthyl methyl ketoneFL/FR
ketoisophoroneFL/FR
coconut
 massoia bark oil CO2 extractFL
 octahydrocoumarinFL/FR
delta-octalactoneFL/FR
coffee
 coffee dioneFL/FR
cooling
dextro-fenchoneFL/FR
 peppermint oil americaFL/FR
creamy
 acetoinFL/FR
 divanillinFL
para-methyl acetophenoneFL/FR
 mint lactoneFL/FR
para-vanillic acidFL/FR
para-vanillyl alcoholFL/FR
 veratraldehydeFL/FR
estery
 octyl propionateFL/FR
ethereal
 ethyl acetateFL/FR
 ethyl formateFL/FR
 methyl isobutyrateFL/FR
fatty
2-ethyl-1-hexanolFL/FR
 nonanoic acidFL/FR
(E)-2-octen-1-olFL/FR
2-octen-1-olFL/FR
(E)-2-octenalFL/FR
floral
2-acetyl-5-methyl thiopheneFL
isoamyl phenyl acetateFL/FR
 citronellyl phenyl acetateFL/FR
 cocoa pentenalFL/FR
 geranyl isobutyrateFL/FR
 hydroxycitronellolFL/FR
 linalyl isobutyrateFL/FR
 methyl phenyl acetateFL/FR
 phenethyl alcoholFL/FR
 rose oil (rosa damascena) russiaFL/FR
 rose oil (rosa damascena) turkeyFL/FR
 tropical iononeFL/FR
 tuberose absolute (from pommade)FL/FR
fruity
 allyl hexanoateFL/FR
 benzyl acetateFL/FR
 benzyl isobutyrateFL/FR
isobutyl acetoacetateFL/FR
isobutyl anthranilateFL/FR
 butyl butyrateFL/FR
isobutyl butyrateFL/FR
 butyl isovalerateFL/FR
 citronellyl anthranilateFL/FR
(E)-2-decenoic acidFL
 ethyl 3-(2-furyl) propanoateFL/FR
 ethyl 3-hexenoateFL/FR
 ethyl 3-hydroxyhexanoateFL/FR
 ethyl 3-oxohexanoateFL
 ethyl benzoyl acetateFL/FR
 ethyl butyrateFL/FR
 ethyl isovalerateFL/FR
 ethyl lactateFL/FR
 ethyl methyl-para-tolyl glycidateFL/FR
 ethyl propionateFL/FR
(E,E)-ethyl sorbateFL/FR
 ethyl valerateFL/FR
 furfuryl valerateFL
2-furyl pentyl ketoneFL
 fusel oilFL/FR
3-heptyl dihydro-5-methyl-2(3H)-furanoneFL/FR
2-hexen-1-olFL/FR
 hexyl acetateFL/FR
 hexyl lactateFL/FR
 hexyl phenyl acetateFL/FR
 linalyl isovalerateFL/FR
 linalyl octanoateFL/FR
 menthyl isovalerateFL/FR
 methyl (E)-2-octenoateFL/FR
 methyl (E)-3-nonenoateFL
 methyl 3-hexenoateFL/FR
 methyl 3-nonenoateFL/FR
 methyl anthranilateFL/FR
2-methyl butyl acetateFL/FR
 methyl heptanoateFL/FR
(E,E)-methyl sorbateFL
 methyl valerateFL/FR
 neryl isobutyrateFL/FR
2-pentanoneFL/FR
 pineapple hydroxyhexanoateFL/FR
 prenyl acetateFL/FR
(E)-propyl 2-furan acrylateFL/FR
isopropyl 2-methyl butyrateFL/FR
isopropyl butyrateFL/FR
 propyl butyrateFL/FR
isopropyl formateFL/FR
 propyl hexanoateFL/FR
 propyl isobutyrateFL/FR
isopropyl octanoateFL/FR
 rose butanoateFL/FR
 strawberry glycidate 1 (aldehyde C-16 (so-called))FL/FR
 strawberry glycidate 2FL/FR
 terpinyl valerateFL/FR
 tolualdehydes (mixed o,m,p)FL/FR
 vanilla carboxylateFL/FR
green
 anethum graveolens herb tinctureFL/FR
isobutyl 2-butenoateFL/FR
isobutyl angelateFL/FR
isobutyl isovalerateFL/FR
 clary sage absoluteFL/FR
 cucumber essenceFL/FR
2-ethyl butyraldehydeFL
(Z)-4-hepten-1-olFL/FR
(E)-2-heptenalFL
(Z)-3-hexen-1-yl salicylateFL/FR
 hexyl isobutyrateFL/FR
 methyl heptadienoneFL/FR
(E,Z)-3,6-nonadien-1-yl acetateFL/FR
 phenethyl tiglateFL/FR
3-propylidene phthalideFL/FR
 terpinyl propionateFL/FR
hay
 genet absoluteFL/FR
herbal
 lovage tinctureFL/FR
honey
 ethyl phenyl acetateFL/FR
dehydrated and ground honeyFL
 honey flavorFL
 phenethyl propionateFL/FR
isopropyl phenyl acetateFL/FR
 propyl phenyl acetateFL/FR
jammy
 ethyl cyclopentenoloneFL/FR
 maltyl isobutyrateFL/FR
medicinal
 ethyl benzoateFL/FR
minty
 ethyl salicylateFL/FR
 methyl salicylateFL/FR
 peppermint oil idahoFL/FR
molasses
 molasses blackstrapFL
mushroom
 methional diethyl acetalFL
musk
 ethylene brassylateFL/FR
phenolic
 guaiacyl phenyl acetateFL/FR
potato
sweet potato flavorFL
powdery
 acetophenoneFL/FR
praline
 praline flavorFL
rummy
isobutyl formateFL/FR
 ethyl pyruvateFL/FR
salty
1-(2-hydroxy-4-methoxyphenyl)-3-(pyridin-2-yl)propan-1-oneFL
smoky
2-methoxy-4-vinyl phenolFL/FR
3,4-xylenolFL/FR
spicy
 eugenolFL/FR
isoeugenolFL/FR
isoeugenyl acetateFL/FR
isoeugenyl phenyl acetateFL/FR
alpha-methyl cinnamaldehydeFL/FR
alpha-methyl-(E)-cinnamaldehydeFL/FR
 perillaldehydeFL/FR
para-tolualdehydeFL/FR
sulfurous
S-ethyl thioacetateFL
sweet
 acesulfame potassiumFL
 acetone alcoholFL
 advantameFL
 agave flavorFL
 alitame anhydrousFL
 aspartameFL
 aspartame-acesulfame saltFL
 caramel dioneFL
 corn syrup high fructoseFL
 corn syrupsFL
 dextrose monohydrateFL
3',7-dihydroxy-4'-methoxyflavanFL
 ethyl 3-(2-hydroxyphenyl) propionateFL
 glucosyl steviol glycosidesFL
 hexyl benzoateFL/FR
 honey enhancerFL
 levuloseFL
 luo han fruit concentrateFL
 maltitolFL
 maltoseFL
isomaltuloseFL
 molassesFL
 molasses concentrateFL
 molasses distillatesFL
 molasses flavorFL
laevo-ornithine hydrochlorideFL
 rebaudioside CFL
 rebaudioside C 30%FL
glucosylated rubus suavissimus extract, 60% glucosylated rubusoside glycosidesFL
 sodium 2-(4-methoxyphenoxy) propionateFL
dextro-sorbitolFL
 stevia rebaudiana extract, rebaudioside A 22%FL
 stevia rebaudiana extract, rebaudioside A 60%FL
 stevia rebaudiana extract, rebaudioside A 80%FL
 steviolFL
 steviol glycoside extract, rebaudioside C 22%FL
enzyme modified steviol glycosidesFL
 steviosideFL
 sucraloseFL
maple sugarFL
 sugarFL
 sugar cane distillateFL
 sugar extendersFL
 sugar flavorFL
burnt sugar flavorFL
brown sugar flavorFL
 sugar replacersFL
 sweet & sour candy flavorFL
 sweet flavorFL
 thaumatin b-recombinantFL
 vanilla bean absolute (vanilla planifolia)FL/FR
 vanilla bean absolute (vanilla spp.)FL/FR
 vanilla concentrateFL
 vanilla oleoresin baliFL/FR
 vanilla oleoresin bourbonFL/FR
 vanilla resinoidFL/FR
 vanilla tahitensis fruit extractFL/FR
dextro,laevo-xyloseFL
tropical
 propyl propionateFL/FR
vanilla
 ethyl vanillinFL/FR
 ethyl vanillin propylene glycol acetalFL/FR
 propenyl guaetholFL/FR
 vanilla aromatica fruit extractFL/FR
 vanillinFL/FR
 vanillin propylene glycol acetalFL/FR
 vanillyl acetateFL/FR
 vanillyl isobutyrateFL/FR
vegetable
 tyramineFL
waxy
 ethyl decanoateFL/FR
 ethyl myristateFL/FR
 ethyl octanoateFL/FR
alpha-hexyl cinnamaldehydeFL/FR
 hydroxycitronellalFL/FR
 octyl butyrateFL/FR
4-phenyl-3-buten-2-olFL/FR
 propyl heptanoateFL/FR
 rhodinyl phenyl acetateFL/FR
woody
4-ethyl guaiacolFL/FR
alpha-ionolFL/FR
alpha-terpinyl methyl etherFL/FR
 
Synonyms   Articles   Notes   Search   Top
Potential Uses:
 humectants 
 licoriceFL
 skin conditioning 
Synonyms   Articles   Notes   Search   Top
Occurrence (nature, food, other): note
 licorice root
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Synonyms   Articles   Notes   Search   Top
Synonyms:
(3b,20b)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-b-D-glucopyranuronosyl-a-D-glucopyranosiduronic acid
20b-carboxy-11-oxo-30-norolean-12-en-3b-yl-2-O-b-D-glucopyranuronosyl-a-D-glucopyranosiduronic acid
 glycyram
 glycyron
 glycyrrhetinic acid glycoside
 glycyrrhetinic acid, 18 alpha
 glycyrrhetinic acid, 18 beta
18-beta-glycyrrhizic acid
 glycyrrhizin
 glycyrrizin
 potenlini
Synonyms   Articles   Notes   Search   Top
Articles:
PubMed: Liquorice, a unique "guide drug" of traditional Chinese medicine: a review of its role in drug interactions.
PubMed: Exploring the possible metabolism mediated interaction of Glycyrrhiza glabra extract with CYP3A4 and CYP2D6.
PubMed: Toxicologic evaluation of licorice extract as a cigarette ingredient.
PubMed: Mutual interactions among ingredients of betel quid in inducing genotoxicity on Chinese hamster ovary cells.
PubMed: A Review on the Role of Nutraceuticals as Simple as Se(2+) to Complex Organic Molecules Such as Glycyrrhizin That Prevent as Well as Cure Diseases.
PubMed: Glycyrrhizic acid attenuated glycative stress in kidney of diabetic mice through enhancing glyoxalase pathway.
PubMed: Antidepressant-like effects of Xiaochaihutang in a rat model of chronic unpredictable mild stress.
PubMed: Formulating blackberry leaf mixtures for preparation of infusions with plant derived sources of sweeteners.
PubMed: Ameliorative effect of Pracparatum mungo extract on high cholesterol diets in hamsters.
PubMed: Rikkunshito ameliorates bleomycin-induced acute lung injury in a ghrelin-independent manner.
PubMed: [Simultaneous determination of twelve sweeteners and nine preservatives in foods by solid-phase extraction and LC-MS/MS].
PubMed: [About flavouring substances and flavouring preparations regulation in the field of manufacturing of flavourings and foodstuffs].
PubMed: CDK2 and mTOR are direct molecular targets of isoangustone A in the suppression of human prostate cancer cell growth.
PubMed: Water extract of licorice had anti-viral activity against human respiratory syncytial virus in human respiratory tract cell lines.
PubMed: Subacute toxicity and stability of Soshiho-tang, a traditional herbal formula, in Sprague-Dawley rats.
PubMed: Development of sample preparation method for isoliquiritigenin, liquiritin, and glycyrrhizic acid analysis in licorice by ionic liquids-ultrasound based extraction and high-performance liquid chromatography detection.
PubMed: Anti-inflammatory effect of Sosihotang via inhibition of nuclear factor-kB and mitogen-activated protein kinases signaling pathways in lipopolysaccharide-stimulated RAW 264.7 macrophage cells.
PubMed: Glycyrrhizic acid and 18beta-glycyrrhetinic acid recover glucocorticoid resistance via PI3K-induced AP1, CRE and NFAT activation.
PubMed: Licorice abuse: time to send a warning message.
PubMed: Liquorice reduced cyclosporine bioavailability by activating P-glycoprotein and CYP 3A.
PubMed: Gamma-cyclodextrin production using cyclodextrin glycosyltransferase from Bacillus clarkii 7364.
PubMed: Influence of fungal elicitation on glycyrrhizin production in transformed cell cultures of Abrus precatorius Linn.
PubMed: Glycyrrhizic acid and 18beta-glycyrrhetinic acid modulate lipopolysaccharide-induced inflammatory response by suppression of NF-κB through PI3K p110δ and p110γ inhibitions.
PubMed: Hexane/ethanol extract of Glycyrrhiza uralensis and its active compound isoangustone A induce G1 cycle arrest in DU145 human prostate and 4T1 murine mammary cancer cells.
PubMed: Genotoxicity assessment of Pyungwi-san (PWS), a traditional herbal prescription.
PubMed: Is glycyrrhizin sensitivity increased in anorexia nervosa and should licorice be avoided? Case report and review of the literature.
PubMed: Glycyrrhizic acid and 18beta-glycyrrhetinic acid inhibit inflammation via PI3K/Akt/GSK3beta signaling and glucocorticoid receptor activation.
PubMed: Hexane-ethanol extract of Glycyrrhiza uralensis containing licoricidin inhibits the metastatic capacity of DU145 human prostate cancer cells.
PubMed: Quantification of glycyrrhizin in Glycyrrhiza glabra extract by validated HPTLC densitometry.
PubMed: Inhibition of human renin activity by saponins.
PubMed: EST analysis reveals putative genes involved in glycyrrhizin biosynthesis.
PubMed: Roasted licorice extracts dampen high glucose-induced mesangial hyperplasia and matrix deposition through blocking Akt activation and TGF-beta signaling.
PubMed: Isoangustone A present in hexane/ethanol extract of Glycyrrhiza uralensis induces apoptosis in DU145 human prostate cancer cells via the activation of DR4 and intrinsic apoptosis pathway.
PubMed: Dietary exposure to flavouring substances: from screening methods to detailed assessments using food consumption data collected with EPIC-Soft software.
PubMed: Determination of glycyrrhetic acid after consumption of liquorice and application to a fatality.
PubMed: Liquorice alert.
PubMed: [Culture of transgenic Glycyrrhiza uralensis hairy root with licorice squalene synthase (SQS) gene].
PubMed: Rapid in vivo screening system for anti-oxidant activity using bacterial redox sensor strains.
PubMed: Glycyrrhizin and licorice significantly affect the pharmacokinetics of methotrexate in rats.
PubMed: Licorice flavonoids inhibit eotaxin-1 secretion by human fetal lung fibroblasts in vitro.
PubMed: Neuroprotective effects of glycyrrhizic acid and 18beta-glycyrrhetinic acid in PC12 cells via modulation of the PI3K/Akt pathway.
PubMed: Glycyrrhizic acid modulates t-BHP induced apoptosis in primary rat hepatocytes.
PubMed: Effect of the extracts from Glycyrrhiza uralensis Fisch on the growth characteristics of human cell lines: Anti-tumor and immune activation activities.
PubMed: Bimodal effect of glycyrrhizin on macrophage nitric oxide and prostaglandin E2 production.
PubMed: Hexane/ethanol extract of Glycyrrhiza uralensis licorice suppresses doxorubicin-induced apoptosis in H9c2 rat cardiac myoblasts.
PubMed: Biotransformation of ginsenoside Rb1, crocin, amygdalin, geniposide, puerarin, ginsenoside Re, hesperidin, poncirin, glycyrrhizin, and baicalin by human fecal microflora and its relation to cytotoxicity against tumor cells.
PubMed: [Hypertension due to liquorice and liquorice tea consumption].
PubMed: [Properties of commercial licorice extracts used as a food additive].
PubMed: Determination of glycyrrhizin in liqueurs by on-line coupled capillary isotachophoresis with capillary zone electrophoresis.
PubMed: Activation of rapid signaling pathways and the subsequent transcriptional regulation for the proliferation of breast cancer MCF-7 cells by the treatment with an extract of Glycyrrhiza glabra root.
PubMed: Blockade of cytokine-induced endothelial cell adhesion molecule expression by licorice isoliquiritigenin through NF-kappaB signal disruption.
PubMed: Simultaneous quantification of flavonoids and triterpenoids in licorice using HPLC.
PubMed: Glycyrrhizin.
PubMed: Risk and safety assessment on the consumption of Licorice root (Glycyrrhiza sp.), its extract and powder as a food ingredient, with emphasis on the pharmacology and toxicology of glycyrrhizin.
PubMed: Simultaneous HPLC analysis, with isocratic elution, of glycyrrhizin and glycyrrhetic acid in liquorice roots and confectionery products.
PubMed: Rapid detection of glycyrrhizin by immunochromatographic assay.
PubMed: Evaluation of certain food additives.
PubMed: [Analysis of nine kinds of sweeteners in foods by LC/MS].
PubMed: Ultrasound-assisted extraction methodology as a tool to improve the antioxidant properties of herbal drug Xiao-chia-hu-tang.
PubMed: Toxicologic evaluation of licorice extract as a cigarette ingredient.
PubMed: [Simultaneous determination of stevioside, rebaudioside A and glycyrrhizic acid in foods by HPLC].
PubMed: Effects of Sho-saiko-to extract and its components, Baicalin, baicalein, glycyrrhizin and glycyrrhetic acid, on pharmacokinetic behavior of salicylamide in carbon tetrachloride intoxicated rats.
PubMed: Cytoprotective effects of Glycyrrhizae radix extract and its active component liquiritigenin against cadmium-induced toxicity (effects on bad translocation and cytochrome c-mediated PARP cleavage).
PubMed: Anti-allergic activity of 18beta-glycyrrhetinic acid-3-O-beta-D-glucuronide.
PubMed: Simultaneous identification of soyasaponins and isoflavones and quantification of soyasaponin Bb in soy products, using liquid chromatography/electrospray ionization-mass spectrometry.
PubMed: Several culinary and medicinal herbs are important sources of dietary antioxidants.
PubMed: Source of arsenic in licorice confectionery products.
PubMed: [Prospect of the development of new bactericidal drugs against Helicobacter pylori for eradication therapy].
PubMed: Efficient method for determining the glycyrrhizin content of fresh and dried roots, and root extracts, of Glycyrrhiza species.
PubMed: Licorice and cancer.
PubMed: Sweetener preference of C57BL/6ByJ and 129P3/J mice.
PubMed: The pharmacokinetics of glycyrrhizic acid evaluated by physiologically based pharmacokinetic modeling.
PubMed: Antidiabetic effect of glycyrrhizin in genetically diabetic KK-Ay mice.
PubMed: Isolation and identification of main constituents in an enzymatically hydrolysed licorice extract sweetener.
PubMed: Constituents and their sweetness of food additive enzymatically modified licorice extract.
PubMed: Development of anorexia in concanavalin A-induced hepatitis in mice.
PubMed: A population physiologically based pharmacokinetic/pharmacodynamic model for the inhibition of 11-beta-hydroxysteroid dehydrogenase activity by glycyrrhetic acid.
PubMed: Inhibition of N-acetyltransferase activity and DNA-2-aminofluorene adducts by glycyrrhizic acid in human colon tumour cells.
PubMed: Physiologically based pharmacokinetic modeling of glycyrrhizic acid, a compound subject to presystemic metabolism and enterohepatic cycling.
PubMed: Effects of Sho-saiko-to extract on liver fibrosis in relation to the changes in hydroxyproline and retinoid levels of the liver in rats.
PubMed: Cytotoxic and non-genotoxic effects of arecoline on human buccal fibroblasts in vitro.
PubMed: Localization of enzymes involved in metabolism of glycyrrhizin in contents of rat gastrointestinal tract.
PubMed: Glycyrrhizic acid in liquorice--evaluation of health hazard.
PubMed: Inhibition of mutagenicity in Salmonella typhimurium and skin tumor initiating and tumor promoting activities in SENCAR mice by glycyrrhetinic acid: comparison of 18 alpha- and 18 beta-stereoisomers.
PubMed: The determination of glycyrrhizin in selected UK liquorice products.
PubMed: Effects of some purified saponins on transmural potential difference in mammalian small intestine.
PubMed: Teratogenicity study of ammonium glycyrrhizinate in the Sprague-Dawley rat.
PubMed: [Estimation of daily intake of glycyrrhizic acid according to the market basket studies in Japan (I)].
PubMed: [Glycyrrhizin levels in various food stuffs].
PubMed: Tests for mutagenic effects of ammoniated glycyrrhizin, butylated hydroxytoluene, and gum Arabic in rodent germ cells.
PubMed: Tumorigenicity study of disodium glycyrrhizinate administered orally to mice.
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