EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

ketoisophorone
2,6,6-trimethylcyclohex-2-ene-1,4-dione

Sponsors

Flavor Demo Formulas
Name:2,6,6-trimethylcyclohex-2-ene-1,4-dione
CAS Number: 1125-21-9Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:214-406-2
FDA UNII:72WY3KLB5R
Nikkaji Web:J94.748B
Beilstein Number:2207030
MDL:MFCD00043119
CoE Number:11200
XlogP3-AA:1.00 (est)
Molecular Weight:152.19304000
Formula:C9 H12 O2
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:flavor and fragrance agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
JECFA Food Flavoring:1857 2,6,6-trimethylcyclohex-2-ene-1,4-dione
FLAVIS Number:07.109 (Old)
DG SANTE Food Flavourings:07.109 2,6,6-trimethylcyclohex-2-ene-1,4-dione
FEMA Number:3421 2,6,6-trimethylcyclohex-2-ene-1,4-dione
FDA:No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm: 2,6,6-TRIMETHYLCYCLOHEX-2-ENE-1,4-DIONE
 
Physical Properties:
Appearance:white to yellowish tan green solid or liquid (est)
Assay: 98.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:0.91800 @ 25.00 °C.
Refractive Index:1.49100 @ 20.00 °C.
Melting Point: 23.00 to 28.00 °C. @ 760.00 mm Hg
Boiling Point: 92.00 to 94.00 °C. @ 11.00 mm Hg
Boiling Point: 222.00 °C. @ 760.00 mm Hg
Vapor Pressure:0.158000 mm/Hg @ 25.00 °C. (est)
Flash Point: 205.00 °F. TCC ( 96.11 °C. )
logP (o/w): 0.994 (est)
Soluble in:
 alcohol
 water, slightly
 water, 1839 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor Type: musty
Odor Strength:medium ,
recommend smelling in a 1.00 % solution or less
musty woody sweet tea tobacco leafy
Odor Description:at 1.00 % in dipropylene glycol. musty woody sweet tea tobacco leaf
musty woody sweet tea citrus lemon brown
Odor Description:Musty, woody, sweet, tea, citrus lemon with sI. brown nuances
Mosciano, Gerard P&F 15, No. 4, 59, (1990)
Flavor Type: citrus
citrus floral musty tea green sweet fruity
Taste Description: at 40.00 ppm. Citrus, floral, musty, tea like with green sweet fruity nuances
Mosciano, Gerard P&F 15, No. 4, 59, (1990)
Odor and/or flavor descriptions from others (if found).
Sigma-Aldrich
4-Oxoisophorone, ≥98%, FG
Odor Description:musty; woody; sweet
Taste Description:citrus floral musty tea green sweet fruity
Pell Wall Perfumes
4-Oxoisophorone
Odor Description:Sweet, floral, honey, tea, woody, musty
Unusual and rarely offered ingredient that gives the core odour character to the scent of Buddliea flowers. Deceptively strong. This material was featured at the World Perfumery Congress in 2016.
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: perfuming agents
 
Suppliers:
Apple Flavor & Fragrance
Oxoisophorone
Beijing Lys Chemicals
4-OxoisoPhorone
Berjé
ketoisophorone
Happening at Berje
BOC Sciences
For experimental / research use only.
4-oxoisoPhorone
DeLong Chemicals America
2,6,6-Trimethylcyclohex-2-ene-1,4-dione
EMD Millipore
For experimental / research use only.
2,6,6-Trimethyl-2-cyclohexene-1,4-dione
M&U International
4-OXOISOPHORONE, Kosher
Pell Wall Perfumes
4-Oxoisophorone 10%
Odor: Sweet, floral, honey, tea, woody, musty
Use: Unusual and rarely offered ingredient that gives the core odour character to the scent of Buddliea flowers. Deceptively strong, and here offered at 10% dilution in ethanol to make it more affordable.
Pell Wall Perfumes
4-Oxoisophorone
Odor: Sweet, floral, honey, tea, woody, musty
Use: Unusual and rarely offered ingredient that gives the core odour character to the scent of Buddliea flowers. Deceptively strong. This material was featured at the World Perfumery Congress in 2016.
Penta International
2,6,6-TRIMETHYLCYCLOHEX-2-ENE-1,4-DIONE, Kosher
Shanghai Vigen Fine Chemical
4-Oxoisophorone
Sigma-Aldrich
4-Oxoisophorone, ≥98%, FG
Odor: musty; woody; sweet
Certified Food Grade Products
Sunaux International
4-oxoisoPhorone
Synerzine
2,6,6-Trimethyl Cyclohex-2-ene-1,4-dione
TCI AMERICA
For experimental / research use only.
4-Ketoisophorone >98.0%(GC)
Tengzhou Xiang Yuan Aroma Chemicals
2,6,6-Trimethyl-2-cyclohexene-1,4-dione
Vigon International
Ketoisophorone Pure (Oxophorone-4)
Odor: FOOD-LIKE, FRUITY
WEN International
4-OXOISOPHORONE
Synthetic
 
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
Xn - Harmful.
R 22 - Harmful if swallowed.
R 38 - Irritating to skin.
R 43 - May cause sensitisation by skin contact.
S 02 - Keep out of the reach of children.
S 20/21 - When using do not eat, drink or smoke.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 37/39 - Wear suitable gloves and eye/face protection.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: flavor and fragrance agents
Recommendation for ketoisophorone usage levels up to:
  2.0000 % in the fragrance concentrate.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 50.00 (μg/capita/day)
Modified Theoretical Added Maximum Daily Intake (mTAMDI): 1900 (μg/person/day)
Threshold of Concern:540 (μg/person/day)
Structure Class: II
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 7
 average usual ppmaverage maximum ppm
baked goods: --
beverages(nonalcoholic): -1.00000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: --
fruit ices: --
gelatins / puddings: --
granulated sugar: --
gravies: --
hard candy: -5.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --
 
Food categories according to Commission Regulation EC No. 1565/2000 (EC, 2000) in FGE.06 (EFSA, 2002a). According to the Industry the "normal" use is defined as the average of reported usages and "maximum use" is defined as the 95th percentile of reported usages (EFSA, 2002i).
Note: mg/kg = 0.001/1000 = 0.000001 = 1/1000000 = ppm.
 average usage mg/kgmaximum usage mg/kg
Dairy products, excluding products of category 02.0 (01.0): 7.0000035.00000
Fats and oils, and fat emulsions (type water-in-oil) (02.0): 2.0000010.00000
Edible ices, including sherbet and sorbet (03.0): 3.0000015.00000
Processed fruit (04.1): 2.0000010.00000
Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2): --
Confectionery (05.0): 4.0000020.00000
Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0): --
Bakery wares (07.0): 5.0000025.00000
Meat and meat products, including poultry and game (08.0): 1.000005.00000
Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0): 1.000005.00000
Eggs and egg products (10.0): --
Sweeteners, including honey (11.0): --
Salts, spices, soups, sauces, salads, protein products, etc. (12.0): 2.0000010.00000
Foodstuffs intended for particular nutritional uses (13.0): 3.0000015.00000
Non-alcoholic ("soft") beverages, excl. dairy products (14.1): 2.0000010.00000
Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2): 4.0000020.00000
Ready-to-eat savouries (15.0): 5.0000025.00000
Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0): 2.0000010.00000
 
Safety References:
European Food Safety Athority(efsa):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Flavouring Group Evaluation 213: alpha,beta-Unsaturated alicyclic ketones and precursors from chemical subgroup 2.7 of FGE.19
View page or View pdf

List of apha, beta-Unsaturated Aldehydes and Ketones representative of FGE.19 substances for Genotoxicity Testing [1] - Statement of the Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF)
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 73, Revision 3 (FGE.73Rev3): Consideration of alicyclic alcohols, aldehydes, acids and related esters evaluated by JECFA (59th and 63rd meeting) structurally related to primary saturated or unsaturated alicyclic alcohols, aldehydes, acids and esters evaluated by EFSA in FGE.12Rev4 (2013)
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 9, Revision 5 (FGE.09Rev5): Secondary alicyclic saturated and unsaturated alcohols, ketones and esters containing secondary alicyclic alcohols from chemical group 8 and 30, and an ester of a phenol derivative from chemical group 25
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 87, Revision 2 (FGE.87Rev2): Consideration of bicyclic secondary alcohols, ketones and related esters evaluated by JECFA (63rd meeting) structurally related to bicyclic secondary alcohols, ketones and related esters evaluated by EFSA in FGE.47Rev1 (2008)
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 9, Revision 6 (FGE.09Rev6): Secondary alicyclic saturated and unsaturated alcohols, ketones and esters containing secondary alicyclic alcohols from chemical group 8 and 30, and an ester of a phenol derivative from chemical group 25
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 213, Revision 2 (FGE.213Rev2): Consideration of genotoxic potential for a,-unsaturated alicyclic ketones and precursors from chemical subgroup 2.7 of FGE.19
View page or View pdf

Safety and efficacy of secondary aliphatic saturated or unsaturated alcohols, ketones, ketals and esters with a second secondary or tertiary oxygenated functional group belonging to chemical group 10 when used as flavourings for all animal species
View page or View pdf

EPI System: View
EPA Substance Registry Services (TSCA):1125-21-9
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :62374
National Institute of Allergy and Infectious Diseases:Data
WISER:UN 2811
WGK Germany:3
2,6,6-trimethylcyclohex-2-ene-1,4-dione
Chemidplus:0001125219
 
References:
 2,6,6-trimethylcyclohex-2-ene-1,4-dione
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:1125-21-9
Pubchem (cid):62374
Pubchem (sid):135020326
Pherobase:View
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS):View
HMDB (The Human Metabolome Database):HMDB40216
FooDB:FDB019928
Export Tariff Code:2914.29.5000
Typical G.C.
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
RSC Learn Chemistry:View
 
Potential Blenders and core components note
For Odor
alcoholic
iso
propyl alcohol
FL/FR
aldehydic
decanal (aldehyde C-10)
FL/FR
amber
amber naphthofuran
FL/FR
ambrette seed absolute
FL/FR
cistus ladaniferus resin
FR
animal
methyl (E)-2-octenoate
FL/FR
6-
methyl quinoline
FL/FR
balsamic
amyl phenyl acetate
FL/FR
laevo-
borneol
FL/FR
iso
bornyl formate
FL/FR
brachyleana hutchinsii wood oil
FR
guaiacyl phenyl acetate
FL/FR
guaiyl acetate
FL/FR
myrrh absolute
FL/FR
valerian rhizome absolute
FL/FR
cereal
bran absolute
FR
citrus
bergamot oil
FL/FR
bergamot oil bergaptene reduced italy
FL/FR
bergamot oil turkey
FL/FR
beta-
bisabolol
FL/FR
2-
dodecanone
FL/FR
2-
ethyl-1-hexanol
FL/FR
(±)-2,4,8-
trimethyl-7-nonen-2-ol
FL/FR
10-
undecen-1-ol
FL/FR
verbena absolute france
FL/FR
creamy
3-
heptyl dihydro-5-methyl-2(3H)-furanone
FL/FR
earthy
geosmin
FL/FR
geosmin
FL/FR
(Z)-
linalool oxide (furanoid)
FL/FR
fatty
(E)-2-
octenal
FL/FR
floral
boronia butenal
FR
champaca absolute
FR
delta-
damascone
FL/FR
dimethyl benzyl carbinyl propionate
FR
geranyl formate
FL/FR
geranyl isobutyrate
FL/FR
(Z)-3-
hexen-1-yl salicylate
FL/FR
beta-
ionone
FL/FR
(Z)-
jasmone
FL/FR
methyl dihydrojasmonate
FL/FR
alpha-iso
methyl ionone (90% min.)
FL/FR
2-
methyl naphthalene
FL/FR
neroli oil bigarde
FL/FR
neryl isovalerate
FL/FR
bitter
orangeflower concrete morocco
FR
petitgrain absolute morocco
FL/FR
petitgrain oil morocco
FL/FR
phenethyl isobutyrate
FL/FR
rose butanoate
FL/FR
tea acetate
FR
tetrahydrolinalool
FL/FR
tetrahydrolinalyl acetate
FR
tobacco flower absolute
FR
fruity
alpha-
amyl cinnamyl isovalerate
FL/FR
iso
butyl 2-butenoate
FL/FR
iso
butyl isovalerate
FL/FR
cyclohexanone diethyl acetal
FL/FR
(E)-beta-
damascone
FL/FR
(Z)-beta-
damascone
FL/FR
beta-
damascone
FL/FR
(R)-gamma-
dodecalactone
FL/FR
ethyl 3-hexenoate
FL/FR
ethyl 3-hydroxyhexanoate
FL/FR
(E,E)-
ethyl sorbate
FL/FR
geranyl acetoacetate
FL/FR
heptyl butyrate
FL/FR
menthyl isovalerate
FL/FR
neryl isobutyrate
FL/FR
prenyl acetate
FL/FR
fungal
methyl 2-furoate
FL/FR
green
iso
green methanoindene
FR
hexyl isobutyrate
FL/FR
magnolia flower oil
FL/FR
phenethyl tiglate
FL/FR
rose leaf absolute (rosa centifolia)
FL/FR
hay
beeswax absolute
FL/FR
hay absolute
FR
tobacco leaf absolute
FL/FR
woodruff absolute
FR
herbal
6-
acetoxydihydrotheaspirane
FL/FR
anthemis nobilis flower oil roman
FL/FR
arnica flower oil
FR
clary sage absolute
FL/FR
clary sage oil france
FL/FR
delta-
elemene
FL/FR
herbal undecanone
FR
matricaria chamomilla flower oil
FL/FR
methyl nicotinate
FL/FR
saffron indenone
FL/FR
safranal
FL/FR
tea leaf absolute
FL/FR
theaspirane
FL/FR
yerba mate absolute
FL/FR
honey
methyl phenyl acetate
FL/FR
phenyl acetic acid
FL/FR
licorice
sweet
basil oleoresin
FL/FR
marine
ozone propanal
FR
mentholic
iso
pulegyl acetate
FL/FR
musk
acetyl ethyl tetramethyl tetralin replacer
FR
musk decanolide
FR
opoponax
opoponax resinoid replacer
FR
phenolic
2'-
hydroxyacetophenone
FL/FR
popcorn
2-
acetyl pyridine
FL/FR
spicy
cassia bark oleoresin
FL/FR
(-)-
cubenol
FL/FR
N,N-
diethyl octanamide
FR
2,5-
dimethyl bicyclo(3.2.1)-2-octen-3-yl acetate + 1,4-dimethyl bicyclo(3.2.1)-2-octen-3-yl acetate
FR
ginger root absolute
FL/FR
grains of paradise oil
FL/FR
methyl heptadienone
FL/FR
tea
camellia oleifera leaf extract
FL/FR
tobacco
para-
cresyl isovalerate
FL/FR
3-
ethyl pyridine
FL/FR
methyl benzoxole
FL/FR
tobacco concrete
FR
(E,E/E,Z)-
tobacco cyclohexenone
FL/FR
veltonal (Bedoukian)
FR
tonka
deertongue absolute
FR
gamma-
hexalactone
FL/FR
mint lactone
FL/FR
saffron resinoid
FL/FR
tonka undecanone
FR
tropical
genet absolute
FL/FR
vanilla
propenyl guaethol
FL/FR
woody
agarwood oil (aetoxylon sympetalum)
FR
amber decatriene
FR
cabreuva wood oil
FR
alpha-
cedrene epoxide
FR
cedrol methyl ether
FR
cyperus root oil (cyperus rotundus)
FR
guaiacwood oil 20% in gurjun balsam oil
FR
(-)-
guaiol
FR
gurjun balsam oil
FR
homalomena rubescens root oil
FR
iso
longifolene ketone
FR
para-
menth-3-en-1-ol
FL/FR
patchouli hexanol
FR
sandalwood oil CO2 extract
FL/FR
spikenard oil CO2 extract
FL/FR
timber propanol
FR
tobacarol (IFF)
FR
tobacco nonene
FR
woody dioxolane
FR
woody ether
FR
For Flavor
No flavor group found for these
6-
acetoxydihydrotheaspirane
FL/FR
amyl phenyl acetate
FL/FR
cyclohexanone diethyl acetal
FL/FR
(R)-gamma-
dodecalactone
FL/FR
delta-
elemene
FL/FR
fig leaf absolute
FL
geosmin
FL/FR
grains of paradise oil
FL/FR
guaiyl acetate
FL/FR
(Z)-
linalool oxide (furanoid)
FL/FR
magnolia flower oil
FL/FR
para-
menth-3-en-1-ol
FL/FR
methyl nicotinate
FL/FR
2-
propyl pyridine
FL
spikenard oil CO2 extract
FL/FR
10-
undecen-1-ol
FL/FR
beta-
damascone
FL/FR
alcoholic
alcoholic
iso
propyl alcohol
FL/FR
amber
amber naphthofuran
FL/FR
animal
6-
methyl quinoline
FL/FR
balsamic
myrrh absolute
FL/FR
brown
beeswax absolute
FL/FR
camphoreous
laevo-
borneol
FL/FR
caramellic
3-
ethyl pyridine
FL/FR
methyl 2-furoate
FL/FR
citrus
bergamot oil
FL/FR
bergamot oil bergaptene reduced italy
FL/FR
bergamot oil turkey
FL/FR
beta-
bisabolol
FL/FR
petitgrain oil morocco
FL/FR
(±)-2,4,8-
trimethyl-7-nonen-2-ol
FL/FR
verbena absolute france
FL/FR
coffee
2,4-
dimethyl thiazole
FL
cooling
iso
menthol
FL
theaspirane
FL/FR
corn
2-
acetyl pyridine
FL/FR
creamy
gamma-
hexalactone
FL/FR
mint lactone
FL/FR
earthy
geosmin
FL/FR
fatty
2-
dodecanone
FL/FR
2-
ethyl-1-hexanol
FL/FR
(E)-2-
octenal
FL/FR
floral
geranyl isobutyrate
FL/FR
methyl dihydrojasmonate
FL/FR
alpha-iso
methyl ionone (90% min.)
FL/FR
methyl phenyl acetate
FL/FR
neroli oil bigarde
FL/FR
petitgrain absolute morocco
FL/FR
phenyl acetic acid
FL/FR
tetrahydrolinalool
FL/FR
fruity
alpha-
amyl cinnamyl isovalerate
FL/FR
(Z)-beta-
damascone
FL/FR
(E)-beta-
damascone
FL/FR
ethyl 3-hexenoate
FL/FR
ethyl 3-hydroxyhexanoate
FL/FR
ethyl 3-oxohexanoate
FL
(E,E)-
ethyl sorbate
FL/FR
3-
heptyl dihydro-5-methyl-2(3H)-furanone
FL/FR
menthyl isovalerate
FL/FR
methyl (E)-2-octenoate
FL/FR
neryl isobutyrate
FL/FR
neryl isovalerate
FL/FR
prenyl acetate
FL/FR
rose butanoate
FL/FR
valerian rhizome absolute
FL/FR
grassy
tobacco leaf absolute
FL/FR
green
iso
butyl 2-butenoate
FL/FR
iso
butyl isovalerate
FL/FR
clary sage absolute
FL/FR
cucumber distillates
FL
geranyl formate
FL/FR
(E)-2-
heptenal
FL
heptyl butyrate
FL/FR
(Z)-3-
hexen-1-yl salicylate
FL/FR
hexyl isobutyrate
FL/FR
methyl heptadienone
FL/FR
phenethyl tiglate
FL/FR
iso
phorone
FL
rose leaf absolute (rosa centifolia)
FL/FR
hay
genet absolute
FL/FR
herbal
anthemis nobilis flower oil roman
FL/FR
clary sage oil france
FL/FR
matricaria chamomilla flower oil
FL/FR
saffron indenone
FL/FR
yerba mate absolute
FL/FR
honey
phenethyl isobutyrate
FL/FR
licorice
sweet
basil oleoresin
FL/FR
mushroom
methional diethyl acetal
FL
musty
geranyl acetoacetate
FL/FR
naphthyl
2'-
hydroxyacetophenone
FL/FR
nutty
methyl benzoxole
FL/FR
(E,E/E,Z)-
tobacco cyclohexenone
FL/FR
oily
2-
methyl naphthalene
FL/FR
phenolic
para-
cresyl isovalerate
FL/FR
guaiacyl phenyl acetate
FL/FR
smoky
dextro-
xylose
FL
spicy
cassia bark oleoresin
FL/FR
(-)-
cubenol
FL/FR
ginger root absolute
FL/FR
paprika oleoresin
FL
sweet
acetone alcohol
FL
saffron resinoid
FL/FR
tea
camellia oleifera leaf extract
FL/FR
tea leaf absolute
FL/FR
vanilla
propenyl guaethol
FL/FR
waxy
decanal (aldehyde C-10)
FL/FR
woody
ambrette seed absolute
FL/FR
iso
bornyl formate
FL/FR
delta-
damascone
FL/FR
beta-
ionone
FL/FR
(Z)-
jasmone
FL/FR
iso
pulegyl acetate
FL/FR
safranal
FL/FR
sandalwood oil CO2 extract
FL/FR
 
Potential Uses:
FRamber
FRbalsam
FRcherry
FRcitrus
FRhoney
FLmolasses
FRoriental
 ozone
FRpatchouli
FRraspberry
FLtea
FRtobacco
FRwoody
 
Occurrence (nature, food, other):note
 champaca concrete @ 0.05%
Data GC Search Trop Picture
 clover yellow sweet clover roasted
Search Trop Picture
 honey - up to 8 mg/kg
Search PMC Picture
 lemon balm
Search Trop Picture
 lettuce lamb's lettuce
Search Trop Picture
 saffron
Search Trop Picture
 saffron
Search Trop Picture
 shrimp cooked shrimp
Search PMC Picture
 tea - up to 9 mg/kg
Search Trop Picture
 tea black tea
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 tea green tea
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Synonyms:
 cetotabac
 cyclohex-2-ene-1,4-dione, 2,6,6-trimethyl-
2-cyclohexene-1,4-dione, 2,6,6-trimethyl-
oxopholone
4-ketoisophorone
4-oxo-alpha-isophorone
4-oxoisophorone
6-oxoisophorone
keto-isophorone
ketoisophorone
oxoisophorone
ketoisophorone pure
2,6,6-trimethyl cyclohex-2-ene-1,4-dione
2,2,6-trimethyl cyclohex-5-en-1,4-dione
2,6,6-trimethyl-2-cyclohexene-1,4-dione
3,5,5-trimethyl-2-cyclohexene-1,4-dione
2,2,6-trimethyl-5-cyclohexen-1,4-dione
2,6,6-trimethyl-cyclohex-2-ene-1,4-dione
3,5,5-trimethyl-cyclohex-2-ene-1,4-dione
2,2,6-trimethyl-cyclohex-5-en-1,4-dione
2,6,6-trimethylcyclohex-2-ene-1,4-dione
2,2,6-trimethylcyclohex-5-en-1,4-dione
 

Articles:

US Patents:3,941,828 - Process for the preparation of oxophorones
PubMed:Attraction of the orange mint moth and false celery leaftier moth (Lepidoptera: Crambidae) to floral chemical lures.
J-Stage:Old Yellow Enzyme from Candida macedoniensis Catalyzes the Stereospecific Reduction of the C=C Bond of Ketoisophorone
US Patents:3,981,311 - Aromatic compositions
PubMed:Recombinant S. cerevisiae expressing Old Yellow Enzymes from non-conventional yeasts: an easy system for selective reduction of activated alkenes.
US Patents:3,989,857 - Flavoring phenol or phenol derivative containing food or feed with cycloaliphatic derivatives
PubMed:An ene reductase from Clavispora lusitaniae for asymmetric reduction of activated alkenes.
US Patents:4,014,350 - Aromatic compositions
PubMed:Improved biocatalysts from a synthetic circular permutation library of the flavin-dependent oxidoreductase old yellow enzyme.
PubMed:Comparative characterization of novel ene-reductases from cyanobacteria.
PubMed:Aerobic oxidation of β-isophorone catalyzed by N-hydroxyphthalimide: the key features and mechanism elucidated.
PubMed:Enoate reductases from non conventional yeasts: bioconversion, cloning, and functional expression in Saccharomyces cerevisiae.
PubMed:Bioreduction of α,β-unsaturated ketones and aldehydes by non-conventional yeast (NCY) whole-cells.
PubMed:Composition of sulla (Hedysarum coronarium L.) honey solvent extractives determined by GC/MS: norisoprenoids and other volatile organic compounds.
PubMed:Volatile composition screening of Salix spp. nectar honey: benzenecarboxylic acids, norisoprenoids, terpenes, and others.
PubMed:Rapid method for screening enoate reductase activity in yeasts.
PubMed:Asymmetric reduction of activated alkenes using an enoate reductase from Gluconobacter oxydans.
PubMed:Continuous two-phase flow miniaturised bioreactor for monitoring anaerobic biocatalysis by pentaerythritol tetranitrate reductase.
PubMed:Asymmetric Reduction of Activated Alkenes by Pentaerythritol Tetranitrate Reductase: Specificity and Control of Stereochemical Outcome by Reaction Optimisation.
PubMed:Metabolite and target transcript analyses during Crocus sativus stigma development.
PubMed:Emission of volatile chemicals from flowering dogwood (cornus Florida L.) flowers.
PubMed:Ketoisophorone transformation by Marchantia polymorpha and Nicotiana tabacum cultured cells.
PubMed:Quality and functionality of saffron: quality control, species assortment and affinity of extract and isolated saffron compounds to NMDA and sigma1 (sigma-1) receptors.
PubMed:A variety of volatile compounds as markers in unifloral honey from dalmatian sage (Salvia officinalis L.).
PubMed:In situ product recovery (ISPR) by crystallization: basic principles, design, and potential applications in whole-cell biocatalysis.
PubMed:Floral odor variation in two heterostylous species of Primula.
PubMed:Cloning and overexpression of the old yellow enzyme gene of Candida macedoniensis, and its application to the production of a chiral compound.
PubMed:Anthropogenic organic contaminants in sediments of the Lippe river, Germany.
PubMed:In situ product removal using a crystallization loop in asymmetric reduction of 4-oxoisophorone by Saccharomyces cerevisiae.
PubMed:Molecular markers of anthropogenic activity in sediments of the Havel and Spree Rivers (Germany).
PubMed:Old Yellow Enzyme from Candida macedoniensis catalyzes the stereospecific reduction of the C=C bond of ketoisophorone.
US Patents:Process for the preparation of a diketone derivative
 
Notes:
Blends well with ozone and woody notes. Present in saffron (Crocus sativus) and tea; flavouring ingredient
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