phenethyl alcohol 60-12-8

Home
Organoleptics
- - Organoleptic Properties
    
    Odor Type : floral
    
    Odor Strength : medium
    
    Odor Description:
    at 100.00 %. floral rose dried rose flower rose water
    
    Substantivity : 32 Hour(s)

Physical Properties

Appearance :	colorless clear oily liquid (est)
Assay :	98.00 to 100.00 %
Halogens :	Chlorine free
Food Chemicals Codex Listed :	Yes
Specific Gravity :	1.01500 to 1.02300 @ 25.00 °C.
Pounds per Gallon - (est). :	8.446 to 8.512
Specific Gravity :	1.01600 to 1.02400 @ 20.00 °C.
Pounds per Gallon - est. :	8.464 to 8.531
Refractive Index :	1.53000 to 1.53400 @ 20.00 °C.
Melting Point :	-27.00 to -25.80 °C. @ 760.00 mm Hg
Boiling Point :	219.00 to 221.00 °C. @ 760.00 mm Hg
Boiling Point :	136.00 to 137.00 °C. @ 50.00 mm Hg
PH Number :	7.00
Vapor Pressure :	0.086800 mm/Hg @ 25.00 °C.
Vapor Density :	4.21 ( Air = 1 )
Flash Point :	216.00 °F. TCC ( 102.22 °C. )
logP (o/w) :	1.360
Shelf Life :	24.00 month(s) or longer if stored properly.
Storage :	store in cool, dry place in tightly sealed containers, protected from heat and light.

Safety

Safety Information

Most important hazard(s) :	Xn - Harmful.
	R 21/22 - Harmful in contact with skin and if swallowed. R 36/38 - Irritating to skin and eyes. S 02 - Keep out of the reach of children. S 20/21 - When using do not eat, drink or smoke. S 24/25 - Avoid contact with skin and eyes. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 36 - Wear suitable protective clothing.
Human Experience :	100 %: no skin irritation. 8 % solution: non-sensitising.
Oral/Parenteral Toxicity :
	oral-mouse LD50 800 - 1500 mg/kg (Fassett, 1963) oral-guinea pig LD50 400 - 800 mg/kg (Fassett, 1963) oral-rat LD50 1800 mg/kg (Rumyantsev et al., 1987) oral-rat LD50 [sex: M] 1900 mg/kg 2 Test substance administered as 5% musk ambrette in phenethyl alcohol. (Moreno, 1982e) gavage-rat LD50 [sex: M,F] 1790 mg/kg (Jenner et al., 1964) oral-rat LD50 2234 mg/kg 1 Value based on specific gravity = 1.02. (Zeller & Hoffmann, 1974) oral-rat LD50 [sex: M] 2100 mg/kg 3 Test substance administered as 20% musk ambrette in phenethyl alcohol. (Moreno, 1982f) gavage-rat LD50 [sex: M,F] 2540 mg/kg (Zaitsev & Rakhmanina, 1974) gavage-mouse LD50 [sex: M,F] 2540 mg/kg (Zaitsev & Rakhmanina, 1974) gavage-guinea pig LD50 [sex: M,F] 2540 mg/kg (Zaitsev & Rakhmanina, 1974) gavage-rat LD50 [sex: M,F] 1609 mg/kg (Mallory et al., 1982a) oral-rat LD50 [sex: M,F] 2509 mg/kg 1 Value based on specific gravity = 1.02. (Carpenter et al., 1974) gavage-rat LD50 [sex: F] 3100 mg/kg 4 Test substance administered as beta-phenethyl alcohol. (Grote & Woods, 1955) intraperitoneal-guinea pig LD50 200 mg/kg "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 4642, 1982. oral-guinea pig LD50 2540 mg/kg Voprosy Pitaniya. Problems of Nutrition. Vol. 33(5), Pg. 48, 1974. oral-mouse LD50 2540 mg/kg Voprosy Pitaniya. Problems of Nutrition. Vol. 33(5), Pg. 48, 1974. oral-rabbit LDLo 2000 mg/kg Journal of Economic Entomology. Vol. 48, Pg. 139, 1955. oral-rat LD50 1790 mg/kg GASTROINTESTINAL: GASTRITIS BEHAVIORAL: COMA Food and Cosmetics Toxicology. Vol. 2, Pg. 327, 1964.
Dermal Toxicity :
	skin-guinea pig LD50 > 5 ml/kg Food and Cosmetics Toxicology. Vol. 2, Pg. 327, 1964. subcutaneous-mouse LDLo 1640 mg/kg BEHAVIORAL: COMA BEHAVIORAL: ATAXIA BEHAVIORAL: GENERAL ANESTHETIC Journal of Pharmacology and Experimental Therapeutics. Vol. 14, Pg. 211, 1920. skin-rabbit LD50 790 uL/kg Toxicology and Applied Pharmacology. Vol. 28, Pg. 313, 1974.
Inhalation Toxicity :
	inhalation-rat LC50 > 500 mg/m3 BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BLOOD: NORMOCYTIC ANEMIA Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 52(10), Pg. 83, 1987.

Safety in Use

Safety in Use Information

Category :	flavor and fragrance agents
Maximised Survey-derived Daily Intakes (MSDI-EU) :	1200.00 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA) :	330.00 (μg/capita/day)
Structure Class :	I
Recommendation for phenethyl alcohol fragrance usage levels up to :
	40.0000 % in the fragrance concentrate.
Recommendation for phenethyl alcohol flavor usage levels up to :
	80.0000 ppm in the finished product.

Safety References

European Food Safety Athority(efsa) :	Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...
European Food Safety Authority (EFSA) reference(s) :
Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to: Flavouring Group Evaluation 14 (FGE.14): Phenethyl alcohol, aldehyde, esters, and related phenylacetic acid esters from chemical group 15 (Commission Regulation (EC) No 1565/2000 of 18 July 2000):page or pdf
Flavouring Group Evaluation 55 (FGE.55): Consideration of phenyl-substituted aliphatic alcohols and related aldehydes and esters evaluated by JECFA (63rd meeting) structurally related to phenethyl alcohol, aldehyde, esters and related phenylacetic acid esters evaluated by EFSA in FGE.14 (2005) and aryl-substituted saturated and unsaturated primary alcohol/aldehyde/acid/ester derivatives evaluated by EFSA in FGE.15 (2005) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC):page or pdf
Flavouring Group Evaluation 53 (FGE.53): Consideration of phenethyl alcohol, aldehyde, acid and related acetals and esters evaluated by JECFA (59th meeting) structurally related to phenethyl alcohol, aldehyde, esters and related phenylacetic acid esters evaluated by EFSA in FGE.14 (2005) and one phenoxyethyl ester evaluated in FGE.23 (2006) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC):page or pdf
Flavouring Group Evaluation 14, Revision 1 (FGE.14Rev1): Phenethyl alcohol, aldehyde, acetals, carboxylic acid and related esters from chemical group 15 and 22 [1] - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food:page or pdf
Flavouring Group Evaluation 53, Revision 1 (FGE.53Rev1): Consideration of phenethyl alcohol, aldehyde, acid and related acetals and esters evaluated by JECFA (59th meeting) FGE.23Rev1 (2008):page or pdf
EPI System :	View
Chemicalize.org :	Calculate predicted properties
IUCLID Chemical Data Sheet :	View
ClinicalTrials.gov :	search
Daily Med :	search
NIOSH International Chemical Safety Cards :	search
NLM Hazardous Substances Data Bank :	Search
AIDS Citations :	Search
Cancer Citations :	Search
Toxicology Citations :	Search
EPA GENetic TOXicology :	Search
Env. Mutagen Info. Center :	Search
NLM Developmental and Reproductive Toxicity :	Search
Canada Domestic Sub. List :	Yes
EPA Substance Registry Services (TSCA) :	60-12-8
WISER :	UN 2810
WGK Germany :	1
	2-phenylethanol
DTP/NCI :	406252
Chemidplus :	0000060128
RTECS :	60-12-8