rebaudioside C
dulcoside B
Constit. of Stevia rebaudiana (stevia)
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CAS Number: 63550-99-2Picture of molecule
MDL: MFCD02752304
XlogP3-AA: -2.30 (est)
Molecular Weight: 951.02430000
Formula: C44 H70 O22
Category: sweeteners, flavor enhancers
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist: Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
 FDA/DG SANTE Petitions, Reviews, Notices:
GRN 536 High purity rebaudioside C View-notice PDF
FEMA Number: 4720  rebaudioside C
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Boiling Point: 1070.00 °C. @ 760.00 mm Hg (est)
Flash Point: 591.00 °F. TCC ( 310.50 °C. ) (est)
logP (o/w): -0.851 (est)
Soluble in:
 water, 12.48 mg/L @ 25 °C (est)
Insoluble in:
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Organoleptic Properties:
 sweet  sugar  
Taste Description:
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Cosmetic Information:
None found
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BOC Sciences
For experimental / research use only.
Rebaudioside C
For experimental / research use only.
Rebaudioside C
Matrix Scientific
For experimental / research use only.
Dulcoside B, 95+%
Nacalai USA
For experimental / research use only.
Rebaudioside C
Rebaudioside C
For experimental / research use only.
Rebaudioside C
analytical standard
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Safety Information:
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: sweeteners, flavor enhancers
Recommendation for rebaudioside C usage levels up to:
 not for fragrance use.
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 25. Update in publication number(s): 26
Click here to view publication 25
 average usual ppmaverage maximum ppm
baked goods: 100.00000400.00000
beverages(nonalcoholic): 100.00000400.00000
beverages(alcoholic): 50.00000150.00000
breakfast cereal: 200.00000400.00000
cheese: --
chewing gum: 1000.000001000.00000
condiments / relishes: --
confectionery froastings: 100.00000300.00000
egg products: --
fats / oils: --
fish products: --
frozen dairy: 100.00000300.00000
fruit ices: 100.00000300.00000
gelatins / puddings: 50.00000300.00000
granulated sugar: --
gravies: 50.00000100.00000
hard candy: --
imitation dairy: 80.00000200.00000
instant coffee / tea: --
jams / jellies: 50.00000300.00000
meat products: --
milk products: 100.00000400.00000
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: 50.00000100.00000
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --
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Safety References:
EPI System: View
Chemical Carcinogenesis Research Information System: Search
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 3085268
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 3
Chemidplus: 0063550992
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NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 3085268
Pubchem (sid): 135233038
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS): View
HMDB (The Human Metabolome Database): HMDB34947
FooDB: FDB013540
Export Tariff Code: 3301.29.6000
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
Read: Under the conditions of intended use - New developments in the FEMA GRAS program and the safety assessment of flavor ingredients
Read: A GRAS assessment program for flavor ingredients
Read: Sensory testing for flavorings with modifying properties. Food Technology
Read: Criteria for the safety evaluation of flavoring substances
Read: A procedure for the safety evaluation of natural flavor complexes used as ingredients in food: essential oils
Read: FEMA Expert Panel: 30 Years of safety evaluation for the flavor industry
Read: Consumption ratio and food predominance of flavoring materials
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Potential Blenders and core components note
None Found
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 stevia rebaudiana
Search Trop  Picture
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 dulcoside B
 rebaudioside C natural
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Google Patents: Rebaudioside C and Its Stereoisomers as Natural Product Sweetness Enhancers
US Patents: 8,889,841 - Method for purifying rebaudioside C
PubMed: [Biological conversion of stevioside to steviol by Aspergillus aculeatus and the purification of rebaudioside A].
Leffingwell & Associates: Flavor Properties of FEMA GRAS List 25 flavor chemicals
Google Patents: Methods for using rebaudioside c as a flavor enhancer
US Patents: 8,691,879 - Methods for using rebaudioside C as a flavor enhancer
PubMed: Hydrogenation of the exocyclic olefinic bond at C-16/C-17 position of ent-kaurane diterpene glycosides of Stevia rebaudiana using various catalysts.
PubMed: Simultaneous analysis of steviol and steviol glycosides by liquid chromatography with ultraviolet detection on a mixed-mode column: application to Stevia plant material and Stevia-containing dietary supplements.
PubMed: Stevia rebaudiana Bertoni as a source of bioactive compounds: the effect of harvest time, experimental site and crop age on steviol glycoside content and antioxidant properties.
PubMed: Catalytic Hydrogenation of the Sweet Principles of Stevia rebaudiana, Rebaudioside B, Rebaudioside C, and Rebaudioside D and Sensory Evaluation of Their Reduced Derivatives.
PubMed: Large-scale profiling of diterpenoid glycosides from Stevia rebaudiana using ultrahigh performance liquid chromatography/tandem mass spectrometry.
PubMed: Novel CNGA3 and CNGB3 mutations in two Pakistani families with achromatopsia.
PubMed: Evaluation of steviol and its glycosides in Stevia rebaudiana leaves and commercial sweetener by ultra-high-performance liquid chromatography-mass spectrometry.
PubMed: Molecular characterization and phylogenetic analysis of the complete genome of a porcine sapovirus from Chinese swine.
PubMed: Protective effect and granuloma down-modulation promoted by RP44 antigen a fructose 1,6 bisphosphate aldolase of Schistosoma mansoni.
PubMed: Monitoring stevioside in soju by high-performance liquid chromatography and liquid chromatography/mass spectrometry.
PubMed: Seroprevalence of human granulocytic ehrlichiosis infection in Belgium.
PubMed: Rebaudioside F, a diterpene glycoside from Stevia rebaudiana.
PubMed: Western blot analysis of sera reactive to human monocytic ehrlichiosis and human granulocytic ehrlichiosis agents.
PubMed: Comparison of two recombinant major outer membrane proteins of the human granulocytic ehrlichiosis agent for use in an enzyme-linked immunosorbent assay.
PubMed: Expression of interleukin-1beta, tumor necrosis factor alpha, and interleukin-6 in human peripheral blood leukocytes exposed to human granulocytic ehrlichiosis agent or recombinant major surface protein P44.
Google Patents: High-Purity Rebaudioside C And Process For Purification Of The Same
PubMed: Pulsed-field gel electrophoresis is more efficient than ribotyping and random amplified polymorphic DNA analysis in discrimination of Pasteurella haemolytica strains.
PubMed: Cloning and expression of the 44-kilodalton major outer membrane protein gene of the human granulocytic ehrlichiosis agent and application of the recombinant protein to serodiagnosis.
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