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BT
 

acesulfame potassium
potassium salt of 3,4-dihydro-6-methyl-1,2,3-oxathiazine-4-one-2,2-dioxide

Sponsors

CAS Number: 55589-62-3Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg: 259-715-3
FDA UNII: 23OV73Q5G9
Nikkaji Web: J269.091H
MDL: MFCD00043833
Molecular Weight: 201.24298000
Formula: C4 H4 K N O4 S
NMR Predictor: Predict (works with chrome or firefox)
Category: sweeteners, flavor enhancers
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
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Perfumer and Flavorist: Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
JECFA Food Additive: Acesulfame Potassium
GSFA Codex: Acesulfame potassium (950)
DG SANTE Food Additives: acesulfame K
FDA Mainterm: ACESULFAME POTASSIUM
FDA Regulation:
FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION
Subpart I--Multipurpose Additives
Sec. 172.800 Acesulfame potassium.
 
Physical Properties:
Appearance: white crystalline powder (exp)
Assay: 95.00 to 100.00
Heavey Metals: < 1 mg/kg Pb
Halogens: < 3 mg/kg F
Food Chemicals Codex Listed: No
Boiling Point: 332.00 to 334.00 °C. @ 760.00 mm Hg
Vapor Pressure: 0.000001 mm/Hg @ 25.00 °C. (est)
Flash Point: 311.00 °F. TCC ( 155.00 °C. )
logP (o/w): -0.310 (est)
Soluble in:
 water, 1e+006 mg/L @ 25 °C (est)
 alcohol, very slightly
Insoluble in:
 alcohol
 
Organoleptic Properties:
Odor Type: odorless
Odor Strength: none
Odor Description:
at 100.00 %.
odorless
Flavor Type: sweet
 sweet sugar candy
Taste Description:
sweet sugar candy
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: masking agents
 
Suppliers:
AIDP
Acesulfame K Ace-k 99% - 101%
Anhui Haibei
Acesulfame-k
Anhui Jinghe
Acesulfame-k or Acesulfame Potassium
Atlantic Chemicals
Acesulfame-K
BOC Sciences
For experimental / research use only.
Acesulfame Potassium >98%
Odor: characteristic
Use: Acesulfame potassium is a non-nutritive sweetener.
ECSA Chemicals
Acesulfame-K
Company Profile
Foodchem International
Acesulfame-K
Graham Chemical
Acesulfame Potassium
Jiangyin Healthway
Acesulfame Potassium
New functional food ingredients
Kraft Chemical
Acesulfame K
Kunshan Sainty
Acesulfame K, Kosher
Norman, Fox & Co.
ACE-K
Northwestern Extract
Ace-K
Penta International
ACESULFAME K, Kosher, Halal
Prinova
Acesulfame Potassium
Qingdao Dacon Trading
Ace-K
Sigma-Aldrich
For experimental / research use only.
Acesulfame K for food analysis, ≥99.0%
Silver Fern Chemical
Acesulfame Potassium
Odor: characteristic
Use: Acesulfame potassium is primarily used in the food and beverage industry. It occasionally is used in personal care products such as toothpaste, as well as certain vitamins and supplements.
Sinofi Food Ingredients
Acesulfame Potassium
Flavor: characteristic
Sugar Substitutes, Chewing Gum, Dairy Products, Confections, Baking Food, Yogurt, Desserts, Alcoholic Beverages, Beverage Powder, Instant Coffee, Chai Tea, Gelatins, Puddings, Ice Cream, Cosmetics, Feed, Pharmaceutical.
TCI AMERICA
For experimental / research use only.
Acesulfame K >97.0%(T)
The Ingredient House
RightSweet Acesulfame K
Universal Preserv-A-Chem Inc.
ACESULFAME K (Potassium) FCC Kosher
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: sweeteners, flavor enhancers
Recommendation for acesulfame potassium usage levels up to:
 not for fragrance use.
 
 
Safety References:
European Food Safety Authority (EFSA) reference(s):
Safety of the proposed extension of use of acesulfame K (E 950) in foods for special medical purposes in young children
View page or View pdf
EPI System: View
ClinicalTrials.gov: search
Chemical Carcinogenesis Research Information System: Search
Cancer Citations: Search
Toxicology Citations: Search
Carcinogenic Potency Database: Search
Env. Mutagen Info. Center: Search
NLM Developmental and Reproductive Toxicity: Search
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 23683747
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 1
 potassium 6-methyl-2,2-dioxooxathiazin-4-olate
Chemidplus: 0055589623
 
References:
 potassium 6-methyl-2,2-dioxooxathiazin-4-olate
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 55589-62-3
Pubchem (cid): 23683747
Pubchem (sid): 135019383
 
Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS): View
CHEMBL: View
HMDB (The Human Metabolome Database): HMDB33955
FooDB: FDB012173
Export Tariff Code: 2934.99.9000
FDA Listing of Food Additive Status: View
Household Products: Search
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
 
Potential Blenders and core components note
For Odor
For Flavor
No flavor group found for these
1-
acetyl cyclohexyl acetate
FL
2-
acetyl-3,4,5,6-tetrahydropyridine
FL
allyl 2-furoate
FL
benzyl disulfide
FL
2,5-
diethyl tetrahydrofuran
FL
fig leaf absolute
FL
furfuryl acetone
FL
mango furanone
FL
acidic
acidic
dextro,laevo-
tartaric acid
FL
burnt
furfuryl alcohol
FL
buttery
diacetyl
FL
caramellic
caramel furanone
FL
5-
ethyl-3,4,5,6-tetramethyl cyclohexen-2-one
FL
3-
methyl butyl 2-furyl butyrate
FL
coffee
2-
thiophene thiol
FL
creamy
2-
propanoyl thiophene
FL
fatty
2,4-
undecadienal
FL
(E,E)-2,4-
undecadienal
FL
fruity
furfuryl valerate
FL
2-
pentanoyl furan
FL
green
(E)-3-
hexenoic acid
FL
herbal
5-
hydroxymethyl furfural
FL
meaty
2-
mercaptomethyl pyrazine
FL
nutty
3,5(6)-
cocoa pyrazine
FL
peanut oxazole
FL
sour
2,4-
dimethyl-2-pentenoic acid
FL
sweet
alitame anhydrous
FL
aspartame
FL
aspartame-acesulfame salt
FL
caramel dione
FL
dextro-
sorbitol
FL
thaumatin
FL
waxy
furfuryl octanoate
FL
 
Potential Uses:
 masking agents 
 oral care agents 
 sweetener 
 
Occurrence (nature, food, other): note
 not found in nature
 
Synonyms:
 ace K
 acesulfame K
 acesulfame potassium
6-methyl-1,2,3-oxathiazin-4 -one2,2-dioxidepotassiumsalt
6-methyl-1,2,3-oxathiazin-4(3H)-one 2,2-dioxide potassium salt
6-methyl-1,2,3-oxathiazin-4(3H)-one 2,2-dioxide, potassium salt
6-methyl-1,2,3-oxathiazin-4(3H)-one2,2-dioxidepotassiumsalt
6-methyl-3H-1,2,3-oxathiazine-2,2,4-trione, potassium salt
1,2,3-oxathiazin-4-ol, 6-methyl-, 2,2-dioxide, potassium salt (1:1)
1,2,3-oxathiazin-4(3H)-one, 6-methyl-, 2,2-dioxide, potassium salt
 potassium 6-methyl-1,2,3-oxathiazin-4(3H)-one 2,2-dioxide
 potassium 6-methyl-2,2-dioxooxathiazin-4-olate
 potassium 6-methyl-4-oxo-4H-1,2,3-oxathiazin-3-ide 2,2-dioxide
 potassium acesulfame
 potassium salt of 3,4-dihydro-6-methyl-1,2,3-oxathiazine-4-one-2,2-dioxide
 potassium salt of 6-methyl-1,2,3-oxathiazine-4(3H)-one-2,2-dioxide
 

Articles:

PubMed: Spatial characteristics of professional tennis serves with implications for serving aces: A machine learning approach.
PubMed: Low-calorie sweetener use and energy balance: Results from experimental studies in animals, and large-scale prospective studies in humans.
PubMed: [Development of a New Method for Determination of Sodium Saccharin and Acesulfame Potassium with the Aid of Coagulant].
PubMed: Nonnutritive Sweeteners in Breast Milk.
PubMed: [Association between non-nutritive sweeteners and obesity risk among university students in Latin America].
PubMed: Simultaneous determination of sweeteners in beverages by LC-MS/MS.
PubMed: [Consumption of carbonated beverages with nonnutritive sweeteners in Latin American university students].
PubMed: Acesulfame-K and pharmaceuticals as co-tracers of municipal wastewater in a receiving river.
PubMed: Quantification of acesulfame potassium in processed foods by quantitative 1H NMR.
PubMed: Allergic reaction caused by acesulfame potassium in foods.
PubMed: [Modification of fasting blood glucose in adults with diabetes mellitus type 2 after regular soda and diet soda intake in the State of Querétaro, Mexico].
PubMed: Precise measurement for the purity of amino acid and peptide using quantitative nuclear magnetic resonance.
PubMed: Sweet Taste-Sensing Receptors Expressed in Pancreatic ő≤-Cells: Sweet Molecules Act as Biased Agonists.
PubMed: Effects of three intense sweeteners on fat storage in the C. elegans model.
PubMed: [A rapid dialysis method for analysis of artificial sweeteners in food].
PubMed: [Comprehensive evaluation of palatability for commercial medicine by taste sensing system].
PubMed: A case study involving allergic reactions to sulfur-containing compounds including, sulfite, taurine, acesulfame potassium and sulfonamides.
PubMed: Ingestion of bacterial lipopolysaccharide inhibits peripheral taste responses to sucrose in mice.
PubMed: Artificial sweeteners stimulate adipogenesis and suppress lipolysis independently of sweet taste receptors.
PubMed: Long-term artificial sweetener acesulfame potassium treatment alters neurometabolic functions in C57BL/6J mice.
PubMed: Bitterness of the non-nutritive sweetener acesulfame potassium varies with polymorphisms in TAS2R9 and TAS2R31.
PubMed: Effect of sweeteners and hydrocolloids on quality attributes of reduced-calorie carrot juice.
PubMed: Lack of functionally active sweet taste receptors in the jejunum in vivo in the rat.
PubMed: Validation of the Korean Addenbrooke's Cognitive Examination for diagnosing Alzheimer's dementia and mild cognitive impairment in the Korean elderly.
PubMed: Bitterness prediction of H1-antihistamines and prediction of masking effects of artificial sweeteners using an electronic tongue.
PubMed: Effect of the artificial sweetener, acesulfame potassium, a sweet taste receptor agonist, on glucose uptake in small intestinal cell lines.
PubMed: Anticonvulsant activity of artificial sweeteners: a structural link between sweet-taste receptor T1R3 and brain glutamate receptors.
PubMed: Metabolic acidosis mimicking diabetic ketoacidosis after use of calorie-free mineral water.
PubMed: Angiotensin I-converting enzyme inhibitory proteins and peptides from the rhizomes of Zingiberaceae plants.
PubMed: Inhibitory activities of baicalin against renin and angiotensin-converting enzyme.
PubMed: [Simultaneous determination of six food additives in meat products by high performance liquid chromatography].
PubMed: Rational development of taste masked oral liquids guided by an electronic tongue.
PubMed: An electronic tongue: evaluation of the masking efficacy of sweetening and/or flavoring agents on the bitter taste of epinephrine.
PubMed: Inadequate toxicity tests of food additive acesulfame.
PubMed: General and persistent effects of high-intensity sweeteners on body weight gain and caloric compensation in rats.
PubMed: Incretin release from gut is acutely enhanced by sugar but not by sweeteners in vivo.
PubMed: NTP toxicology studies of acesulfame potassium (CAS No. 55589-62-3) in genetically modified (FVB Tg.AC Hemizygous) mice and carcinogenicity studies of acesulfame potassium in genetically modified [B6.129-Trp53(tm1Brd) (N5) Haploinsufficient] mice (feed studies)mice.
PubMed: Sweet taste receptors in rat small intestine stimulate glucose absorption through apical GLUT2.
PubMed: Exploratory studies to investigate a linked prebiotic origin of RNA and coded peptides. 3rd communication. Behaviour of 5-amino-1H-imidazole-4-carbonitrile derivatives.
PubMed: Testing needed for acesulfame potassium, an artificial sweetener.
PubMed: Action mechanism of an angiotensin I-converting enzyme inhibitory peptide derived from chicken breast muscle.
PubMed: [Analysis of nine kinds of sweeteners in foods by LC/MS].
PubMed: Utility of the ammonia-free Birch reduction of electron-deficient pyrroles: total synthesis of the 20s proteasome inhibitor, clasto-lactacystin beta-lactone.
PubMed: Scope of the reductive aldol reaction: application to aromatic carbocycles and heterocycles.
PubMed: The powder flow and compact mechanical properties of sucrose and three high-intensity sweeteners used in chewable tablets.
PubMed: Determination of acesulfame and sucralose in oral electrolyte maintenance solution by liquid chromatography.
PubMed: [Simultaneous determination of various food additives by high performance liquid chromatography].
PubMed: Gustatory responses of the hamster Mesocricetus auratus to various compounds considered sweet by humans.
PubMed: Noncariogenic intense natural sweeteners.
PubMed: Gustatory neural coding in the monkey cortex: the quality of sweetness.
 
Notes:
ADI 15 mg/kg (1991). Intense-type sweetener permitted at 300-5500 ppm in foods. Sweetness approx. 200 x sucrose Acesulfame potassium is a calorie-free artificial sweetener, also known as Acesulfame K or Ace K (K being the symbol for potassium), and marketed under the trade names Sunett and Sweet One. In the European Union, it is known under the E number (additive code) E950. It was discovered accidentally in 1967 by German chemist Karl Clauss at Hoechst AG (now Nutrinova). In chemical structure, acesulfame potassium is the potassium salt of 6-methyl-1,2,3- oxathiazine-4(3H)-one 2,2-dioxide. It is a white crystalline powder with molecular formula C4H4KNO4S and a molecular weight of 201.24.
 
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