alpha-hexyl cinnamaldehyde
alpha-hexylcinnamaldehyde

Sponsors

Fragrance Demo Formulas
Name: 2-(phenylmethylidene)octanal
CAS Number: 101-86-0Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg: 202-983-3
FDA UNII: 7X6O37OK2I
MDL: MFCD00006989
CoE Number: 129
XlogP3-AA: 4.80 (est)
Molecular Weight: 216.32360000
Formula: C15 H20 O
NMR Predictor: Predict (works with chrome or firefox)
Category: flavor and fragrance agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist: Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
JECFA Food Flavoring: 686 alpha-hexylcinnamaldehyde
Flavis Number: 05.041 (Old)
DG SANTE Food Flavourings: 05.041 alpha-hexylcinnamaldehyde
FEMA Number: 2569 alpha-hexylcinnamaldehyde
FDA Mainterm: ALPHA-HEXYLCINNAMALDEHYDE
FDA Regulation:
FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION
Subpart F--Flavoring Agents and Related Substances
Sec. 172.515 Synthetic flavoring substances and adjuvants.
 
Physical Properties:
Appearance: pale yellow to yellow clear liquid to solid (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: Yes
Specific Gravity: 0.95100 to 0.95900 25.00 °C.
Pounds per Gallon - (est).: 7.913 to 7.980
Specific Gravity: 0.95200 to 0.96000 @ 20.00 °C.
Pounds per Gallon - est.: 7.931 to 7.997
Refractive Index: 1.54700 to 1.55200 @ 20.00 °C.
Boiling Point: 174.00 to 176.00 °C. @ 15.00 mm Hg
Boiling Point: 140.00 to 142.00 °C. @ 3.00 mm Hg
Acid Value: 2.00 max. KOH/g
Vapor Pressure: 0.001000 mm/Hg @ 25.00 °C. (est)
Flash Point: 235.00 °F. TCC ( 113.00 °C. )
logP (o/w): 4.866 (est)
Shelf Life: 12.00 month(s) or longer if stored properly.
Storage: store in cool, dry place in tightly sealed containers, protected from heat and light. store under nitrogen.
Storage: store under nitrogen.
Soluble in:
 fixed oils
 paraffin oil
 water, 2.75 mg/L @ 25 °C (est)
Insoluble in:
 water
 glycerin
 propylene glycol
Stability:
 acid cleaner
 alcoholic lotion
 alkalis
 antiperspirant
 deo stick
 detergent perborate
 fabric softener
 hard surface cleaner
 liquid detergent
 shampoo
 soap
Similar Items: note
alpha-amyl cinnamaldehyde
alpha-butyl cinnamaldehyde
alpha-heptyl cinnamaldehyde
alpha-methyl cinnamaldehyde
 
Organoleptic Properties:
Odor Type: floral
Odor Strength: medium
Substantivity: 400 hour(s) at 100.00 %
 fresh floral green jasmin herbal waxy
Odor Description:
at 100.00 %.
fresh floral green jasmin herbal waxy
Luebke, William tgsc, (1985)
 sweet floral green citrus fruity powdery tropical spicy
Odor Description:
Sweet, floral, green, citrus and fruity with powdery tropical spicy notes
Mosciano, Gerard P&F 19, No. 6, 53, (1994)
Flavor Type: waxy
 sweet waxy floral green citrus fruity
Taste Description:
at 5.00 ppm.
Sweet, waxy, floral, green, citrus and fruity nuances
Mosciano, Gerard P&F 19, No. 6, 53, (1994)
Odor and/or flavor descriptions from others (if found).
Moellhausen
ALPHA-HEXYLCINNAMIC ALDEHYDE
Odor Description: aromatic, floreal
Taste Description: sweet, fruity
Pell Wall Perfumes
Hexyl Cinnamaldehyde
Odor Description: Sweet, floral-jasmine, green, citrus-fruity, powdery, spicy
According to Arctander it is: “Very mild, sweet-oily, slightly floral odor with a trace of hcrbaccous undertones. The odor becomes considerably more floral and lively when the material is incorporated with more volatile material in a composition… This aidehyde finds considerable use in perfume formulations for its rich floral and pleasant oily-herbaccous odor-contribution to Jasmin bases, Gardenia, Tuberose, Magnolia, etc. and in general as part of a floral theme in other fragrance types.”
 
Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: perfuming agents
 
Suppliers:
Advanced Biotech
HEXYL CINNAMIC ALDEHYDE NATURAL
Alfrebro
alpha-HEXYL CINNAMALDEHYDE NATURAL
Odor: Jasmine, Cinnamon
Associate Allied Chemicals
alpha-Hexyl Cinnamic Aldehyde
About
Augustus Oils
Hexyl Cinnamic Aldehyde
Services
Berjé
alpha-Hexyl Cinnamic Aldehyde
Happening at Berje
BOC Sciences
For experimental / research use only.
alpha-Hexylcinnamaldehyde
CG Herbals
Hexyl Cinnamic Aldehyde
Charkit Chemical
HEXYL CINNAMIC ALDEHYDE
Creatingperfume.com
alpha-Hexyl Cinnamaldehyde
Odor: Fresh, floral, green, jasmin, herbal, waxy
Diffusions Aromatiques
ALDEHYDE HEXYL CINAMIQUE (JASMONAL H)
ECSA Chemicals
alpha-Hexyl Cinnamic Aldehyde
Company Profile
Emerald Kalama Chemical
Hexyl Cinnamic Aldehyde (HCA)
96.0% minimum (sum of cis & trans isomers)
Odor: Floral, jasmine, lily, green
Ernesto Ventós
HEXYL CINNAMIC ALDEHYDE KAO
Odor: FLORAL,JASMIN,ROSE, GERANIUM LEAVES
Ernesto Ventós
HEXYL CINNAMIC ALDEHYDE, ALPHA (HINDUSTAN)
Eternis Fine Chemicals
Hexyl Cinnamic Aldehyde
Odor: Floral, Fruity, Jasmine-like, mild, Fresh
Use: Hexyl Cinnamic Aldehyde, a pale yellow liquid is an economical floral note with jasmin waxy / fatty character. Blends well and is widely combined with other floral notes and used extensively in all main fragrance types, particularly in fabric care and soaps.
ExtraSynthese
For experimental / research use only.
Hexylcinnamaldehyde (GC) ≥98%
Global Essence
Hexyl Cinnamic Aldehyde
Indukern F&F
ALPHA HEXYL CINNAMIC ALDEHYDE NATURAL
Odor: FLORAL, JASMIN, GARDENIA
Indukern F&F
ALPHA HEXYL CINNAMIC ALDEHYDE
Odor: FLORAL, JASMIN, GARDENIA
Inoue Perfumery
HEXYL CINNAMALDEHYDE
Kao Corporation
HEXYL CINNAMIC ALDEHYDE
Odor: Floral with Jasmine character
Lluch Essence
alpha-HEXYL CINNAMIC ALDEHYDE
MG International Fragrance
Hexylcinnamal NAL
Odor: 26 Allergens and allergen derivates free Myltle Oil replacement
Moellhausen
ALPHA-HEXYLCINNAMIC ALDEHYDE
Odor: aromatic, floreal
Flavor: sweet, fruity
Nagar Haveli Perfumes & Aromatics
Hexyl Cinnamic Aldehyde
Natural
Odor: Fresh floral green jasmin herbal waxy
Pell Wall Perfumes
Hexyl Cinnamaldehyde
Odor: Sweet, floral-jasmine, green, citrus-fruity, powdery, spicy
Use: According to Arctander it is: “Very mild, sweet-oily, slightly floral odor with a trace of hcrbaccous undertones. The odor becomes considerably more floral and lively when the material is incorporated with more volatile material in a composition… This aidehyde finds considerable use in perfume formulations for its rich floral and pleasant oily-herbaccous odor-contribution to Jasmin bases, Gardenia, Tuberose, Magnolia, etc. and in general as part of a floral theme in other fragrance types.”
Penta International
HEXYL CINNAMIC ALDEHYDE, Kosher
Penta International
HEXYL CINNAMIC ALDEHYDE, NATURAL, Kosher
PerfumersWorld
HCA Hexyl Cinnamic Aldehyde
Odor: aromatic floral jasmin gardenia
Perfumery Laboratory
Hexyl Cinnamaldehyde
Odor: Sweet, green, floral fragrance with a citrus tint
Phoenix Aromas & Essential Oils
Hexyl Cinnamic Aldehyde
Prinova
Hexyl (Hca) Cinnamic Aldehyde (Nh)
Prodasynth
HEXYL CINNAMIC ALDEHYDE
> 96%, TRANS > 90%
Odor: FLORAL,JASMIN,ROSE, GERANIUM LEAVES
Reincke & Fichtner
alpha-Hexylcinnamaldehyde
Santa Cruz Biotechnology
For experimental / research use only.
a-Hexylcinnamaldehyde
Sigma-Aldrich
a-Hexylcinnamaldehyde, ≥95%, stabilized, FG
Odor: jasmine; lily; sweet
Certified Food Grade Products
SRS Aromatics
HEXYL CINNAMIC ALDEHYDE
Taytonn
Hexyl Cinnamic Aldehyde
TCI AMERICA
For experimental / research use only.
alpha-Hexylcinnamaldehyde >90.0%(GC)
The Good Scents Company
alpha-hexyl cinnamaldehyde
Odor: fresh floral green jasmin herbal waxy
The John D. Walsh Company
Hexyl Cinnamic Aldehyde
The Lermond Company
Hexyl Cinnamic Aldehyde
The Perfumers Apprentice
Hexyl Cinnamaldehyde
Odor: Mild and sweet oily slightly floral
Treatt
Hexyl Cinnamic Aldehyde
Ungerer & Company
alpha-Hexyl Cinnamaldehyde
Vigon International
Hexyl Cinnamic Aldehyde Natural
Vigon International
Hexyl Cinnamic Aldehyde
Zanos
Hexyl Cinnamic Aldehyde
 
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
Xi - Irritant
R 38 - Irritating to skin.
R 43 - May cause sensitisation by skin contact.
S 02 - Keep out of the reach of children.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 27 - Take off immediately all contaminated clothing.
S 36 - Wear suitable protective clothing.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
Skin sensitisation (Category 1), H317
Acute aquatic toxicity (Category 3), H402
Chronic aquatic toxicity (Category 3), H412
GHS Label elements, including precautionary statements
 
Pictogramexclamation-mark.jpg
 
Signal word Warning
Hazard statement(s)
H317 - May cause an allergic skin reaction
H402 - Harmful to aquatic life
H412 - Harmful to aquatic life with long lasting effects
Precautionary statement(s)
P261 - Avoid breathing dust/fume/gas/mist/vapours/spray.
P272 - Contaminated work clothing should not be allowed out of the workplace.
P273 - Avoid release to the environment.
P280 - Wear protective gloves/protective clothing/eye protection/face protection.
P302 + P352 - IF ON SKIN: wash with plenty of soap and water.
P321 - Specific treatment (see supplemental first aid instructions on this label).
P333 + P313 - IF SKIN irritation or rash occurs: Get medical advice/attention.
P363 - Wash contaminated clothing before reuse.
P501 - Dispose of contents/ container to an approved waste disposal plant.
Human Experience:
12 % solution: no irritation or sensitization.
Oral/Parenteral Toxicity:
oral-rat LD50 3100 mg/kg
Food and Cosmetics Toxicology. Vol. 12, Pg. 915, 1974.

oral-mouse LD50 2300 mg/kg
SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 55(6), Pg. 86, 1990.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: flavor and fragrance agents
IFRA Critical Effect: Sensitization
IFRA: View Standard
Fragrance usage is IFRA RESTRICTED. View Standard for complete information.
Please review all IFRA documents for complete information.
IFRA categories: limits in the finished product: (For a description of the categories, refer to the IFRA QRA Information Booklet.)
Category 1:
See Note (1)
0.70 % (1)
Category 2:  0.90 %
Category 3:  3.60 %
Category 4:  10.70 %
Category 5:  5.60 %
Category 6:  17.10 % (1)
Category 7:  1.80 %
Category 8:  2.00 %
Category 9:  5.00 %
Category 10:  2.50 %
Category 11: See Note (2)
 Notes:
 

(1) IFRA would recommend that any material used to impart perfume or flavour in products intended for human ingestion should consist of ingredients that are in compliance with appropriate regulations for foods and food flavourings in the countries of planned distribution and, where these are lacking, with the recommendations laid down in the Code of Practice of IOFI (International Organisation of the Flavor Industry). Further information about IOFI can be found on its website (www.iofi.org).

 

(2) Category 11 includes all non-skin contact or incidental skin contact products. Due to the negligible skin contact from these types of products there is no justification for a restriction of the concentration of this fragrance ingredient in the finished product.

 
Maximised Survey-derived Daily Intakes (MSDI-EU): 74.00 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 11.00 (μg/capita/day)
Structure Class: II
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
 average usual ppmaverage maximum ppm
baked goods: -2.40000
beverages(nonalcoholic): -0.80000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: -2.60000
fruit ices: -2.60000
gelatins / puddings: -0.05000
granulated sugar: --
gravies: --
hard candy: -6.50000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --
 
Safety References:
Flavor & Extract Manufacturers Association (FEMA) reference(s):
The FEMA GRAS assessment of cinnamyl derivatives used as flavor ingredients.View pdf
European Food Safety Athority(efsa): Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...
European Food Safety Authority (EFSA) reference(s):
Flavouring Group Evaluation 214: alpha,beta-Unsaturated aldehydes and precursors from chemical subgroup 3.1 of FGE.19: Cinnamyl derivatives[1]
View page or View pdf
Scientific Opinion on Flavouring Group Evaluation 68 (FGE.68): Consideration of cinnamyl alcohol and related flavouring agents evaluated by JECFA (55th meeting) evaluated by EFSA in FGE.15Rev1 (2008)
View page or View pdf
Safety and efficacy of aryl-substituted primary alcohol, aldehyde, acid, ester and acetal derivatives belonging to chemical group 22 when used as flavourings for all animal species
View page or View pdf
EPI System: View
Cancer Citations: Search
Toxicology Citations: Search
Env. Mutagen Info. Center: Search
EPA Substance Registry Services (TSCA): 101-86-0
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 7585
National Institute of Allergy and Infectious Diseases: Data
SCCNFP: opinion
WGK Germany: 2
 2-(phenylmethylidene)octanal
Chemidplus: 0000101860
RTECS: GD6560000 for cas# 101-86-0
 
References:
 2-(phenylmethylidene)octanal
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 101-86-0
Pubchem (cid): 7585
Pubchem (sid): 29226414
 
Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS): View
CHEBI: View
CHEMBL: View
HMDB (The Human Metabolome Database): HMDB31736
FooDB: FDB008404
Export Tariff Code: 2912.29.6000
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
 
Potential Blenders and core components note
For Odor
aldehydic
iso
butyraldehyde
FL/FR
citrus carbaldehyde
FR
6,7,8-
decen-1-ol
FR
dodecanal (aldehyde C-12 lauric)
FL/FR
3-
methyl-4-hexyl oxybutyraldehyde
FR
nonanal (aldehyde C-9)
FL/FR
N/i-
tridecanal
FR
10-
undecenal (aldehyde C-11 undecylenic)
FL/FR
animal
animal carbolactone
FR
costus valerolactone
FR
indole
FL/FR
methyl (E)-2-octenoate
FL/FR
anise
anise seed oil
FL/FR
sweet
fennel seed oil
FL/FR
anisic
ocimum basilicum herb oil
FL/FR
aromatic
(4E,9Z)-13-
methyloxacyclopentadeca-4,9-dien-2-one
FR
balsamic
iso
amyl benzoate
FL/FR
amyris wood oil
FL/FR
benzophenone
FL/FR
benzyl salicylate
FL/FR
iso
butyl cinnamate
FL/FR
cinnamyl alcohol
FL/FR
cinnamyl formate
FL/FR
clover nitrile
FR
ethyl cinnamate
FL/FR
fir balsam absolute
FR
fir needle oil siberia
FL/FR
methyl (E)-cinnamate
FL/FR
3-
phenyl propyl alcohol
FL/FR
berry
raspberry ketone methyl ether
FL/FR
buttery
acetoin
FL/FR
caramellic
ethyl maltol
FL/FR
cheesy
iso
valeric acid
FL/FR
chocolate
cocoa pentenal
FL/FR
citrus
bergamot oil
FL/FR
bergamot oil bergaptene reduced italy
FL/FR
bergamot oil turkey
FL/FR
citral diethyl acetal
FL/FR
citral dimethyl acetal
FL/FR
citrus floral green fragrance
FR
2,4-
dimethyl-3-cyclohexene-1-methanyl acetate
FR
grapefruit pentanol
FR
lemongrass oil
FL/FR
nonanal dimethyl acetal
FL/FR
blood
orange oil italy
FL/FR
sweet
orange peel oil c.p. brazil
FL/FR
(E)-2-
tetradecenal
FL/FR
2-
tetradecenal
FL/FR
tetrahydromyrcenol
FR
coconut
gamma-
heptalactone
FL/FR
gamma-
octalactone
FL/FR
fatty
decanol
FL/FR
2-
decenal
FL/FR
(E,Z,Z)-2,4,7-
tridecatrienal
FL/FR
floral
acetaldehyde dibutyl acetal
FL/FR
amyl benzoate
FL/FR
alpha-
amyl cinnamaldehyde
FL/FR
alpha-
amyl cinnamaldehyde dimethyl acetal
FL/FR
amyl salicylate
FL/FR
iso
amyl salicylate
FL/FR
anisyl propanal / methyl anthranilate schiff's base
FR
benzyl acetone
FL/FR
bois de rose oil brazil
FL/FR
boronia absolute
FL/FR
boronia concrete
FL/FR
alpha-
butyl cinnamaldehyde
FL/FR
iso
butyl salicylate
FL/FR
citronellal
FL/FR
citronellol
FL/FR
citronellyl acetate
FL/FR
(S)-
citronellyl acetate
FL/FR
citronellyl butyrate
FL/FR
citronellyl phenyl acetate
FL/FR
citronellyl propionate
FL/FR
(E)-
citronellyl tiglate
FL/FR
coriander seed oil
FL/FR
coriander seed oil CO2 extract
FL/FR
cumin carbinol
FR
cyclamen aldehyde
FL/FR
cyclohexyl ethyl alcohol
FL/FR
dictamnus hispanicus oil
FR
dihydrocarvyl acetate
FL/FR
(±)-2,3-
dihydrofarnesol
FL/FR
dihydroisojasmonate methyl ester
FR
dihydrojasmone
FL/FR
dimethyl benzyl carbinol
FL/FR
dimethyl benzyl carbinyl acetate
FL/FR
dimethyl benzyl carbinyl butyrate
FL/FR
6,8-
dimethyl-2-nonanol
FR
ethyl phenoxyacetate
FR
farnesol
FL/FR
farnesyl acetate
FL/FR
floral butanal
FR
floral pyranol
FR
floral undecenone
FR
gardenia absolute
FR
gardenia acetal
FR
gardenia concrete
FR
gardenia oxide
FR
gelsone (IFF)
FL/FR
geraniol
FL/FR
geranium oil
FL/FR
geranium oil africa
FL/FR
geranyl acetate
FL/FR
geranyl acetone
FL/FR
geranyl formate
FL/FR
geranyl hexanoate
FL/FR
geranyl isobutyrate
FL/FR
geranyl nonanoate
CS
geranyl propionate
FL/FR
heliotropyl acetone
FL/FR
(Z)-4-
hepten-2-yl salicylate
FR
herbal pyran
FR
hexahydrofarnesyl acetone
FL/FR
(Z)-3-
hexen-1-yl salicylate
FL/FR
hexyl lactate
FL/FR
hyacinth ether
FR
hyacinth oil
FR
hydrangea fragrance
FR
hydroxycitronellal
FL/FR
hydroxycitronellal diethyl acetal
FL/FR
hydroxycitronellal dimethyl acetal
FL/FR
hydroxycitronellal propylene glycol acetal
FL/FR
hydroxycitronellol
FL/FR
beta-
ionone
FL/FR
jasmin acetate
FL/FR
jasmin cyclopentanol
FR
iso
jasmone
FL/FR
iso
jasmone
FL/FR
jonquil absolute
FR
leerall
FR
lilac absolute
FR
lily fragrance
FR
lily propanol
FR
linalool
FL/FR
laevo-
linalool
FL/FR
linalool oxide
FL/FR
linalyl butyrate
FL/FR
linalyl phenyl acetate
FL/FR
linalyl propionate
FL/FR
lotus fragrance
FR
magnolia indene
FR
(2-
methoxy-1-methyl propyl) benzene
FR
(3-
methoxy-2-methyl propyl) benzene
FR
1-(2-
methyl allyl oxy)-2-methyl butane
FR
methyl dihydrojasmonate
FL/FR
mimosa absolute
FL/FR
mimosa absolute france
FL/FR
mimosa absolute india
FL/FR
mimosa absolute morocco
FL/FR
muguet carboxaldehyde
FR
nerol
FL/FR
neroli oil bigarde
FL/FR
neroli oil CO2 extract
FL/FR
nerolidol
FL/FR
(E)-
nerolidol
FL/FR
neryl acetate
FL/FR
neryl formate
FL/FR
3-
nonanone
FL/FR
ocean propanal
FL/FR
ocean propanal / methyl anthranilate schiff's base
FR
octyl acetate
FL/FR
orange leaf absolute
FL/FR
bitter
orangeflower absolute morocco
FL/FR
bitter
orangeflower absolute tunisia
FL/FR
orchid specialty
FR
orris pyridine 25% IPM
FR
orris rhizome resinoid (iris pallida)
FL/FR
papaya isobutyrate
FL/FR
peony alcohol
FR
petitgrain oil paraguay
FL/FR
phenethyl acetate
FL/FR
phenethyl alcohol
FL/FR
phenethyl butyrate
FL/FR
phenethyl hexanoate
FL/FR
phenethyl isobutyrate
FL/FR
phenethyl phenyl acetate
FL/FR
phenethyl propionate
FL/FR
phenyl acetaldehyde dicitronellyl acetal
FR
phenyl acetaldehyde diisobutyl acetal
FL/FR
2-
phenyl propionaldehyde dimethyl acetal
FL/FR
2-
phenyl propionaldehyde ethylene glycol acetal
FR
(Z,E)-
phytol
FL/FR
rhodinol
FL/FR
rhodinyl formate
FL/FR
rose butanoate
FL/FR
(Z)-
rose oxide
FL/FR
laevo-
rose oxide
FL/FR
rose pyran
FR
styralyl formate
FL/FR
styralyl isobutyrate
FL/FR
styralyl propionate
FL/FR
sweet pea absolute
FR
terpinyl isobutyrate
FL/FR
tetrahydrolinalool
FL/FR
5-
tricyclodecenyl acetate
FR
(S,E)-3,7,11-
trimethyldodeca-6,10-dienal
FR
verdyl acetate
FR
violet methyl carbonate
FR
ylang ylang flower oil
FL/FR
ylang ylang flower oil III
FL/FR
fresh
3-(3-
propen-2-yl phenyl) butanal
FR
fruity
acetaldehyde dihexyl acetal
FL/FR
allyl amyl glycolate
FR
allyl butyrate
FL/FR
benzyl methyl ether
FL/FR
3-
benzyl-4-heptanone
FL/FR
iso
butyl 2-methyl butyrate
FL/FR
cinnamyl isobutyrate
FL/FR
citronellyl isobutyrate
FL/FR
cyclohexyl crotonate
FR
gamma-
decalactone
FL/FR
decen-1-yl cyclopentanone
FL/FR
alpha,alpha-
dimethyl benzyl isobutyrate
FL/FR
dimethyl succinate
FL/FR
ethyl 2-octenoate
FL/FR
ethyl methyl-para-tolyl glycidate
FL/FR
geranyl butyrate
FL/FR
green acetate
FR
(E)-2-
hepten-1-yl acetate
FL/FR
heptyl isobutyrate
FL/FR
(Z)-3-
hexen-1-yl 2-methyl-2-pentenoate
FR
methyl anthranilate
FL/FR
methyl nonanoate
FL/FR
neryl propionate
FL/FR
peach pivalate
FR
phenoxyethyl propionate
FL/FR
prenyl acetate
FL/FR
(E,E)-5,6,7,7-
tetramethyl-2,5-octadien-4-one
FR
tropical ionone
FL/FR
gamma-
undecalactone (aldehyde C-14 (so-called))
FL/FR
(E)-2-
undecenal
FL/FR
fungal
jasmin nonane
FR
green
acetaldehyde ethyl phenethyl acetal
FL/FR
iso
amyl 3-(2-furan) propionate
FL/FR
iso
butyl benzyl carbinol
FL/FR
chrysanthemum oxide
FL/FR
cognac heptanone
FL/FR
para-
dimethyl hydroquinone
FL/FR
3,7-
dimethyl-6-octenoic acid
FL/FR
diphenyl oxide
FL/FR
earthy acetal
FL/FR
flower hexene
FR
galbanum oil
FL/FR
green cyclopropionate
FR
(Z)-3-
hexen-1-yl acetoacetate
FL/FR
(Z)-3-
hexen-1-yl angelate
FR
(Z)-3-
hexen-1-yl benzoate
FL/FR
(E)-2-
hexen-1-yl hexanoate
FL/FR
hexen-1-yl oxypropane nitrile
FR
(Z)-3-
hexen-1-yl phenyl acetate
FL/FR
hexyl (Z)-tiglate
FL/FR
hexyl 2-methyl butyrate
FL/FR
hyacinth absolute
FL/FR
ivy dioxolane
FR
(Z)-
leaf acetal
FL/FR
marigold pot absolute
FL/FR
melon nonenoate
FL/FR
(2-
methoxy-1-methyl butyl) benzene
FR
[(4E,4Z)-5-
methoxy-3-methyl-4-penten-1-yl] benzene
FR
methyl cyclocitrone (IFF)
FR
methyl heptine carbonate
FL/FR
para-
methyl hydratropaldehyde
FL/FR
methyl octine carbonate
FL/FR
4-
methyl-4-phenyl pentanone
FR
narcissus flower absolute
FR
(E,Z)-2,6-
nonadien-1-ol
FL/FR
(E,Z)-2,6-
nonadienal
FL/FR
octyl oxyacetaldehyde
FR
pelargonium graveolens stem leaf extract
FR
phenyl acetaldehyde
FL/FR
phenyl acetaldehyde dimethyl acetal
FL/FR
phenyl acetaldehyde solution
FL/FR
3-
phenyl propionaldehyde
FL/FR
privet dioxane
FR
thiogeraniol
FL/FR
violet leaf absolute
FL/FR
hay
hay absolute
FR
herbal
chrysanthemum ketone
FR
clary sage absolute
FL/FR
clary sage oil france
FL/FR
coriander oleoresin
FL/FR
dehydroxylinalool oxide
FL/FR
dihexyl (E)-fumarate
FR
beta-
elemene
FL/FR
freesia heptanol
FL/FR
lavender absolute bulgaria
FL/FR
linalyl acetate
FL/FR
2-
methyl butyl salicylate
FL/FR
5-
methyl-3-heptanone
FL/FR
(1S,5R)-
myrtenyl acetate
FL/FR
perillaldehyde
FL/FR
phenyl acetaldehyde diisoamyl acetal
FR
rosmarinus officinalis extract
FL/FR
marine
green
algae absolute
FL/FR
medicinal
kunzea ericoides leaf oil
FR
melon
watermelon ketone
FR
mossy
oakmoss absolute
FL/FR
veramoss (IFF)
FR
powdery
para-
anisyl alcohol
FL/FR
spicy
alpha-
amyl cinnamyl alcohol
FL/FR
bayberry fragrance
FR
cinnamyl propionate
FL/FR
cuminaldehyde
FL/FR
iso
cyclogeraniol (IFF)
FR
iso
eugenyl acetate
FL/FR
methyl isoeugenol
FL/FR
myrcene
FL/FR
pimenta acris leaf oil
FL/FR
spicy carbonate
FR
tea
camellia oleifera leaf extract
FL/FR
terpenic
frankincense oil
FL/FR
juniperus communis fruit oil
FL/FR
alpha-
terpineol
FL/FR
tonka
gamma-
hexalactone
FL/FR
tonka bean absolute
FR
tropical
hexyl 2-methyl-3-pentenoate
FL/FR
waxy
3-
decanone
FL/FR
1-
dodecanol
FL/FR
ethyl laurate
FL/FR
ethyl myristate
FL/FR
ethyl octanoate
FL/FR
octanol
FL/FR
orris rhizome oil CO2 extract
FL/FR
1-
undecanol
FL/FR
woody
camphene
FL/FR
patchouli ethanone
FR
sandal cyclopentane
FR
santall
FR
vetiver oil haiti
FL/FR
woody acetate
FR
For Flavor
No flavor group found for these
acetaldehyde dibutyl acetal
FL/FR
green
algae absolute
FL/FR
amyl benzoate
FL/FR
alpha-
amyl cinnamaldehyde dimethyl acetal
FL/FR
boronia concrete
FL/FR
3-
decanone
FL/FR
(±)-2,3-
dihydrofarnesol
FL/FR
earthy acetal
FL/FR
beta-
elemene
FL/FR
(E)-2-
hepten-1-yl acetate
FL/FR
(Z)-3-
hexen-1-yl acetoacetate
FL/FR
hexyl (Z)-tiglate
FL/FR
hyacinth absolute
FL/FR
hydroxycitronellal propylene glycol acetal
FL/FR
linalyl phenyl acetate
FL/FR
methyl (E)-cinnamate
FL/FR
2-
methyl butyl salicylate
FL/FR
phenyl acetaldehyde solution
FL/FR
styralyl formate
FL/FR
styralyl isobutyrate
FL/FR
terpinyl isobutyrate
FL/FR
2-
tetradecenal
FL/FR
iso
amyl 3-(2-furan) propionate
FL/FR
alpha-
butyl cinnamaldehyde
FL/FR
aldehydic
aldehydic
iso
butyraldehyde
FL/FR
nonanal (aldehyde C-9)
FL/FR
1-
undecanol
FL/FR
amber
iso
butyl benzyl carbinol
FL/FR
animal
indole
FL/FR
anise
anise seed oil
FL/FR
sweet
fennel seed oil
FL/FR
apple
(E,Z)-2,6-
nonadien-1-ol
FL/FR
aromatic
amyl salicylate
FL/FR
balsamic
benzyl salicylate
FL/FR
iso
butyl cinnamate
FL/FR
ethyl cinnamate
FL/FR
fir needle oil siberia
FL/FR
(Z,E)-
phytol
FL/FR
berry
heliotropyl acetone
FL/FR
heptyl isobutyrate
FL/FR
raspberry ketone methyl ether
FL/FR
bitter
(E,Z,Z)-2,4,7-
tridecatrienal
FL/FR
camphoreous
camphene
FL/FR
caramellic
ethyl maltol
FL/FR
cheesy
iso
valeric acid
FL/FR
citrus
bergamot oil
FL/FR
bergamot oil bergaptene reduced italy
FL/FR
bergamot oil turkey
FL/FR
citral diethyl acetal
FL/FR
citral dimethyl acetal
FL/FR
cognac heptanone
FL/FR
freesia heptanol
FL/FR
lemongrass oil
FL/FR
linalool
FL/FR
laevo-
linalool
FL/FR
nerol
FL/FR
blood
orange oil italy
FL/FR
sweet
orange peel oil c.p. brazil
FL/FR
petitgrain oil paraguay
FL/FR
styralyl propionate
FL/FR
alpha-
terpineol
FL/FR
verbena oil france
FL
cooling
iso
butyl salicylate
FL/FR
creamy
acetoin
FL/FR
gamma-
hexalactone
FL/FR
gamma-
undecalactone (aldehyde C-14 (so-called))
FL/FR
fatty
2-
decenal
FL/FR
(Z)-3-
hexen-1-yl benzoate
FL/FR
10-
undecenal (aldehyde C-11 undecylenic)
FL/FR
floral
bois de rose oil brazil
FL/FR
cinnamyl propionate
FL/FR
citronellal
FL/FR
citronellol
FL/FR
(S)-
citronellyl acetate
FL/FR
citronellyl acetate
FL/FR
citronellyl phenyl acetate
FL/FR
citronellyl propionate
FL/FR
cocoa pentenal
FL/FR
dihydrocarvyl acetate
FL/FR
dihydrojasmone
FL/FR
dimethyl benzyl carbinyl acetate
FL/FR
dimethyl benzyl carbinyl butyrate
FL/FR
3,7-
dimethyl-6-octenoic acid
FL/FR
farnesol
FL/FR
farnesyl acetate
FL/FR
geraniol
FL/FR
geranium oil
FL/FR
geranium oil africa
FL/FR
geranyl acetone
FL/FR
geranyl isobutyrate
FL/FR
jasmin acetate
FL/FR
linalyl acetate
FL/FR
linalyl butyrate
FL/FR
methyl dihydrojasmonate
FL/FR
mimosa absolute morocco
FL/FR
neroli oil bigarde
FL/FR
neroli oil CO2 extract
FL/FR
neryl acetate
FL/FR
ocean propanal
FL/FR
orange leaf absolute
FL/FR
bitter
orangeflower absolute morocco
FL/FR
bitter
orangeflower absolute tunisia
FL/FR
orris rhizome resinoid (iris pallida)
FL/FR
phenethyl alcohol
FL/FR
phenethyl propionate
FL/FR
rhodinol
FL/FR
laevo-
rose oxide
FL/FR
tetrahydrolinalool
FL/FR
tropical ionone
FL/FR
ylang ylang flower oil
FL/FR
ylang ylang flower oil III
FL/FR
fruity
iso
amyl benzoate
FL/FR
para-
anisyl alcohol
FL/FR
benzyl acetone
FL/FR
benzyl methyl ether
FL/FR
3-
benzyl-4-heptanone
FL/FR
boronia absolute
FL/FR
iso
butyl 2-methyl butyrate
FL/FR
cinnamyl isobutyrate
FL/FR
citronellyl butyrate
FL/FR
citronellyl isobutyrate
FL/FR
gamma-
decalactone
FL/FR
decen-1-yl cyclopentanone
FL/FR
alpha,alpha-
dimethyl benzyl isobutyrate
FL/FR
dimethyl succinate
FL/FR
ethyl (E)-2-octenoate
FL
ethyl 2-octenoate
FL/FR
ethyl methyl-para-tolyl glycidate
FL/FR
geranyl butyrate
FL/FR
geranyl hexanoate
FL/FR
hexyl 2-methyl-3-pentenoate
FL/FR
hexyl lactate
FL/FR
methyl (E)-2-octenoate
FL/FR
methyl anthranilate
FL/FR
5-
methyl-3-heptanone
FL/FR
neryl formate
FL/FR
phenethyl butyrate
FL/FR
2-
phenyl propionaldehyde dimethyl acetal
FL/FR
prenyl acetate
FL/FR
rhodinyl formate
FL/FR
rose butanoate
FL/FR
geranium
benzophenone
FL/FR
green
acetaldehyde dihexyl acetal
FL/FR
acetaldehyde ethyl phenethyl acetal
FL/FR
allyl butyrate
FL/FR
iso
amyl salicylate
FL/FR
chrysanthemum oxide
FL/FR
cinnamyl alcohol
FL/FR
(E)-
citronellyl tiglate
FL/FR
clary sage absolute
FL/FR
coriander oleoresin
FL/FR
cyclamen aldehyde
FL/FR
cyclohexyl ethyl alcohol
FL/FR
3,4-
dimethoxystyrene
FL
para-
dimethyl hydroquinone
FL/FR
diphenyl oxide
FL/FR
galbanum oil
FL/FR
gelsone (IFF)
FL/FR
geranyl acetate
FL/FR
geranyl formate
FL/FR
hexahydrofarnesyl acetone
FL/FR
(E)-2-
hexen-1-yl hexanoate
FL/FR
(Z)-3-
hexen-1-yl phenyl acetate
FL/FR
(Z)-3-
hexen-1-yl salicylate
FL/FR
hexyl 2-methyl butyrate
FL/FR
hibiscus distillates
FL
iso
jasmone
FL/FR
iso
jasmone
FL/FR
(Z)-
leaf acetal
FL/FR
linalool oxide
FL/FR
marigold pot absolute
FL/FR
melon nonenoate
FL/FR
methyl 2-undecynoate
FL
methyl heptine carbonate
FL/FR
para-
methyl hydratropaldehyde
FL/FR
methyl octine carbonate
FL/FR
(E)-
nerolidol
FL/FR
nerolidol
FL/FR
neryl propionate
FL/FR
(E,Z)-2,6-
nonadienal
FL/FR
nonanal dimethyl acetal
FL/FR
3-
nonanone
FL/FR
oakmoss absolute
FL/FR
papaya isobutyrate
FL/FR
phenyl acetaldehyde diisobutyl acetal
FL/FR
phenyl acetaldehyde dimethyl acetal
FL/FR
3-
phenyl propionaldehyde
FL/FR
(Z)-
rose oxide
FL/FR
violet leaf absolute
FL/FR
herbal
clary sage oil france
FL/FR
coriander seed oil
FL/FR
coriander seed oil CO2 extract
FL/FR
lavender absolute bulgaria
FL/FR
linalyl propionate
FL/FR
ocimum basilicum herb oil
FL/FR
rosmarinus officinalis extract
FL/FR
honey
phenethyl acetate
FL/FR
phenethyl isobutyrate
FL/FR
phenethyl phenyl acetate
FL/FR
phenyl acetaldehyde
FL/FR
lactonic
gamma-
heptalactone
FL/FR
gamma-
octalactone
FL/FR
medicinal
dimethyl benzyl carbinol
FL/FR
melon
hydroxycitronellal diethyl acetal
FL/FR
minty
thiogeraniol
FL/FR
powdery
hydroxycitronellol
FL/FR
soapy
dodecanal (aldehyde C-12 lauric)
FL/FR
1-
dodecanol
FL/FR
spicy
alpha-
amyl cinnamyl alcohol
FL/FR
cinnamyl formate
FL/FR
cuminaldehyde
FL/FR
iso
eugenyl acetate
FL/FR
methyl isoeugenol
FL/FR
perillaldehyde
FL/FR
3-
phenyl propyl alcohol
FL/FR
pimenta acris leaf oil
FL/FR
tea
camellia oleifera leaf extract
FL/FR
terpenic
juniperus communis fruit oil
FL/FR
tropical
alpha-
amyl cinnamaldehyde
FL/FR
malibu moment flavor
FL
waxy
decanol
FL/FR
ethyl laurate
FL/FR
ethyl myristate
FL/FR
ethyl octanoate
FL/FR
geranyl propionate
FL/FR
hydroxycitronellal
FL/FR
hydroxycitronellal dimethyl acetal
FL/FR
mimosa absolute
FL/FR
mimosa absolute france
FL/FR
mimosa absolute india
FL/FR
octanol
FL/FR
octyl acetate
FL/FR
phenethyl hexanoate
FL/FR
phenoxyethyl propionate
FL/FR
(E)-2-
tetradecenal
FL/FR
(E)-2-
undecenal
FL/FR
winey
methyl nonanoate
FL/FR
woody
amyris wood oil
FL/FR
dehydroxylinalool oxide
FL/FR
frankincense oil
FL/FR
beta-
ionone
FL/FR
myrcene
FL/FR
(1S,5R)-
myrtenyl acetate
FL/FR
orris rhizome oil CO2 extract
FL/FR
vetiver oil haiti
FL/FR
 
Potential Uses:
 acacia cassie farnesianaFR
 anais anais 
 apple blossomFR
 balsamFR
 bayberryFR
 bouquetFR
 bubble gumFR
 cedarFR
 charlie 
 chloe 
 christmas blendsFR
 citrusFR
 clean 
 cloth clean cloths 
 coconut tropicalFR
 crabapple blossomFR
 estee 
 fern fougereFR
 fidji 
 figFR
 fir balsamFR
 floralFR
 florida breeze 
 fresh & cleanFR
 gardeniaFR
 gingerbreadFR
 greenFR
 green grassFR
 green leafFR
 greenhouseFR
 heatherFR
 herbalFR
 honeysuckle chevrefeuilleFR
 jasminFR
 kiwiFR
 l'air du temps 
 lilac lilas syringaFR
 lilyFR
 magnoliaFR
 mangoFR
 meadow countryFR
 muguet lily of the valleyFR
 narcissus narcisseFR
 neroliFR
 new car 
 norell 
 orchidFR
 orris irisFR
 outdoors freshFR
 paris 
 peachFR
 plumFR
 rainFR
 rain springFR
 roseFR
 spiceFR
 strawberryFR
 tropicalFL
 tuberoseFR
 woodyFR
 
Occurrence (nature, food, other): note
 chamomile
Search PMC Picture
 
Synonyms:
2-benzylidene octanal
2-benzylideneoctanal
 hexyl (hca) cinnamic aldehyde (nh)
 hexyl cinnamal
 hexyl cinnamaldehyde
2-hexyl cinnamaldehyde
a-hexyl cinnamaldehyde
alpha-hexyl cinnamaldehyde
 hexyl cinnamic aldehyde
alpha-hexyl cinnamic aldehyde
alpha-N-hexyl cinnamic aldehyde
 hexyl cinnamic aldehyde natural
alpha-hexyl cinnamic aldehyde natural
 hexyl cinnamic aldehyde, natural
alpha-hexyl cinnamyl aldehyde
2-hexyl-3-phenyl-2-propenal
alpha-N-hexyl-beta-phenyl acrolein
a-hexylcinnamaldehyde
alpha-hexylcinnamaldehyde
alpha-hexylcinnamic aldehyde
 jasmonal H
 octanal, 2-(phenylmethylene)-
2-(phenyl methylene) octanal
2-(phenylmethylidene)octanal
 

Articles:

PubMed: Patch tests with fragrance mix II and its components.
PubMed: Differential gene expression responses distinguish contact and respiratory sensitizers and nonsensitizing irritants in the local lymph node assay.
PubMed: A comparative evaluation of in vitro skin sensitisation tests: the human cell-line activation test (h-CLAT) versus the local lymph node assay (LLNA).
PubMed: [Improvement of local lymph node assay for cosmetics safety evaluation].
PubMed: Expression of surface markers on the human monocytic leukaemia cell line, THP-1, as indicators for the sensitizing potential of chemicals.
PubMed: Volatile signals during pregnancy: a possible chemical basis for mother-infant recognition.
PubMed: Use of an ex vivo local lymph node assay to assess contact hypersensitivity potential.
PubMed: [In vitro evaluation of cutaneous allergic reaction induced by chemicals using dendritic cells].
PubMed: Interlaboratory validation of 1% pluronic l92 surfactant as a suitable, aqueous vehicle for testing pesticide formulations using the murine local lymph node assay.
PubMed: A new dendritic cell type suitable as sentinel of contact allergens.
PubMed: Suitability of macrophage inflammatory protein-1beta production by THP-1 cells in differentiating skin sensitizers from irritant chemicals.
PubMed: Sensitization to 26 fragrances to be labelled according to current European regulation. Results of the IVDK and review of the literature.
PubMed: The skin sensitization potential of resorcinol: experience with the local lymph node assay.
PubMed: Evaluation of an ex vivo murine local lymph node assay: multiple endpoint comparison.
PubMed: Advantage of using CBA/N strain mice in a non-radioisotopic modification of the local lymph node assay.
PubMed: Patch testing with a new fragrance mix - reactivity to the individual constituents and chemical detection in relevant cosmetic products.
PubMed: Patch testing with a new fragrance mix detects additional patients sensitive to perfumes and missed by the current fragrance mix.
PubMed: Assessment of statistic analysis in non-radioisotopic local lymph node assay (non-RI-LLNA) with alpha-hexylcinnamic aldehyde as an example.
PubMed: Assessment of cumulative allergen-activated lymph node cell proliferation using flow cytometry.
PubMed: Principles and methodology for identification of fragrance allergens in consumer products.
PubMed: Further important sensitizers in patients sensitive to fragrances.
PubMed: Cytokine production induced by low-molecular-weight chemicals as a function of the stimulation index in a modified local lymph node assay: an approach to discriminate contact sensitizers from respiratory sensitizers.
PubMed: The suitability of hexyl cinnamic aldehyde as a calibrant for the murine local lymph node assay.
PubMed: Skin sensitisation testing--new perspectives and recommendations.
PubMed: Comparison of mouse strains using the local lymph node assay.
PubMed: Cytokine endpoints for the local lymph node assay: consideration of interferon-gamma and interleukin 12.
PubMed: Development of a non-radioactive endpoint in a modified local lymph node assay.
PubMed: Temporal stability of local lymph node assay responses to hexyl cinnamic aldehyde.
PubMed: Comparison of sex differences in guinea-pig maximization test for detection of skin-sensitizing potential using OECD recommended positive control sensitizers.
PubMed: Natural ingredients based cosmetics. Content of selected fragrance sensitizers.
PubMed: An evaluation of the suitability of benzocaine as a positive control skin sensitizer.
PubMed: Results with OECD recommended positive control sensitizers in the maximization, Buehler and local lymph node assays.
PubMed: Delineation of the intimate details of the backbone conformation of pyridine nucleotide coenzymes in aqueous solution.
 
Notes:
rain accord - cyclamen aldehyde and hexyl cinnamaldehyde. Flavouring agent
 
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