Prefixer for alcohol.
  • Hermitage Oils
    • Hermitage Oils
      Perfumery and Aromatherapy materials since 1979
      Hermitage Oils, the true home of essential oils!
      Hermitage Oils offers a selection of Absolutes, Essential Oils, Natural Isolates, Aroma Chemicals, CO2 Extracts, Ethanol Tinctures, and Extraits by Enfleurage.
      Email: Info
      Email: Sales
      The Vault
      Ambrettolide is one of the finest musks available, this is the musk that gives Ambrette seeds their muskiness. Some people find it mild, others very powerful so most often used in small doses. Has a terrific fixative and radiant effect and also works to enhance other musks that are used with it. It is slightly fruity, very smooth and exalting. Ambrettolide is a macrocyclic musk, like most of those found in nature.
  • PCW France
    • PCW France
      Your partner in Fragrances since 1986
      Our mission is to convey an emotion through perfumery.
      PCW founded in 1986, is based in new world-class facilities in the town of Grasse, France. The company aims at supplying the main materials used in perfumery, directly sourcing from important manufacturers worldwide. More than 1000 high-quality references can be provided all over the world with 48 hours dispatch. There is no minimum order line, feel free to contact us for any enquiry.
      Email: Sales team
      Email: Sales team
      Email: Mrs Eleonore Thore :
      Email: Mrs Jennie Brugnot :
      Voice: +33 (0)4 92 28 23 30
      Fax: +33 (0)4 92 28 23 39
      Steps to a fragranced product
      Products List: View
  • Penta International
    • Penta International Corporation
      Chemistry innovation
      At Penta, our products and services help businesses do business better.
      For over 30 years, Penta Manufacturing Company has played a growing role in worldwide chemistry innovations and applications. As an industry leader, Penta continues to pioneer chemistry-based solutions for practically every area of commerce. Our products and expertise have helped fuel technical advances in dozens of commercial applications including flavoring, coloring, fragrances and chemical processes.
      US Email: Technical Services
      US Email: Sales
      US Voice: (973) 740-2300
      US Fax: (973) 740-1839
      01-24000 AMBRETTOLIDE, Kosher
      01-24002 AMBRETTOLIDE NATURAL, Kosher
  • Sigma-Aldrich
    • Sigma-Aldrich
      Complete Supply Chain
      The perfect blend of products and services that bring your creativity to life.
      Sigma-Aldrich is a leading Life Science and High Technology company dedicated to providing high-quality, safe and certified flavor ingredients with transparent and easily accessible documentation to customers around the globe. Sigma-Aldrich also provides a suite of analytical tools that allow food analysts to simplify sample preparation, cleanup and analysis steps, while increasing sensitivity to trace ingredients and harmful substances to meet regulations and quality standards.
      Email: Information
      US Email: Sales
      US Voice: 800-244-1173
      US Fax: 800-368-4661
      Certified Food Grade Products
      W255505 omega-6-Hexadecenlactone, ≥98%
  • The Lermond Company
    • The Lermond Company
      Your Sourcing Resource
      The Lermond family has been sourcing raw materials for the flavor and fragrance industry for nearly 7 decades.
      The Lermond Company is a women-owned distributor of raw materials primarily servicing the flavor and fragrance industry. For three generations, members of the Lermond family have been integral sourcing partners for the North American flavor and fragrance industry. We supply high quality essential oils, aroma chemicals, absolutes, concretes, resinoids and floral waters from around the world to the global industry.
      Email: Info
      Email: Tara
      Email: Erica
      Voice: 201-896-3300
      Fax: 201-623-2910
Synonyms   Articles   Notes   Search
17-oxacycloheptadec-6-en-1-one (Click)
CAS Number: 7779-50-2
ECHA EINECS - REACH Pre-Reg: 231-929-1
MDL: MFCD00209513
CoE Number: 180
XlogP3-AA: 5.50 (est)
Molecular Weight: 252.39756000
Formula: C16 H28 O2
NMR Predictor: Predict
EFSA/JECFA Comments: JECFA evaluated omega-6-hexadecenlactone (CASrn as in Register). (R)- or (S)-enantiomer not specified by Register CASrn.
Category: flavor and fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist: Search
Google Patents: Search
US Patents: Search
EU Patents: Search
IBM Patents: Obtain
Pubchem Patents: Search
PubMed: Search
NCBI: Search
JECFA Food Flavoring: 240  omega-6-hexadecenlactone
Flavis Number: 10.003 (Old)
DG SANTE Food Flavourings: 10.003  hexadec-6-eno-1,16-lactone
FEMA Number: 2555  omega-6-hexadecenlactone
FDA Regulation:
Subpart F--Flavoring Agents and Related Substances
Sec. 172.515 Synthetic flavoring substances and adjuvants.
Synonyms   Articles   Notes   Search   Top
Physical Properties:
Appearance: colorless to pale yellow clear liquid (est)
Assay: 98.00 to 100.00 % 
Food Chemicals Codex Listed: No
Specific Gravity: 0.95600 @  25.00 °C.
Refractive Index: 1.47900 @  20.00 °C.
Boiling Point: 185.00 to  190.00 °C. @ 16.00 mm Hg
Flash Point: > 212.00 °F. TCC ( > 100.00 °C. )
logP (o/w): 5.429 (est)
Synonyms   Articles   Notes   Search   Top
Organoleptic Properties:
Odor Type: soapy
Odor Strength: medium ,
recommend smelling in a 10.00 % solution or less
 sweet  soapy  musk  amber  fruity  berry  
Odor Description:
at 10.00 % in dipropylene glycol. 
sweet soapy musk amber fruity berry
 sweet  soapy  musk  fruity  
Odor Description:
Sweet, soapy, perfume-like with a heavy fruity undertone
Mosciano, Gerard P&F 17, No. 1, 41, (1992)
 soapy  musk  fruity  berry  
Taste Description:
at 1.00 ppm.  
Soapy, perfume-like with a fruity berry nuance
Mosciano, Gerard P&F 17, No. 1, 41, (1992)
Synonyms   Articles   Notes   Search   Top
Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: perfuming agents
Synonyms   Articles   Notes   Search   Top
Hermitage Oils
Odor: characteristic
Use: Ambrettolide is one of the finest musks available, this is the musk that gives Ambrette seeds their muskiness. Some people find it mild, others very powerful so most often used in small doses. Has a terrific fixative and radiant effect and also works to enhance other musks that are used with it. It is slightly fruity, very smooth and exalting. Ambrettolide is a macrocyclic musk, like most of those found in nature.
The Vault
PCW France
Steps to a fragranced product
Penta International
Penta International
Reincke & Fichtner
omega-6-Hexadecenlactone natural
Reincke & Fichtner
omega-6-Hexadecenlactone, ≥98%
Odor: musty; animal
Certified Food Grade Products
The Lermond Company
Synonyms   Articles   Notes   Search   Top
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
Xi - Irritant
R 36 - Irritating to eyes.
S 02 - Keep out of the reach of children.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 39 - Wear eye/face protection.
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50  > 5000 mg/kg
(Wohl, 1974a)

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: flavor and fragrance agents
Recommendation for ambrettolide usage levels up to:
  5.0000 % in the fragrance concentrate.
Maximised Survey-derived Daily Intakes (MSDI-EU): 5.10 (μg/capita/day)
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
Click here to view publication 3
 average usual ppmaverage maximum ppm
baked goods: -0.19000
beverages(nonalcoholic): -0.32000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: -0.70000
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: -0.19000
fruit ices: -0.18000
gelatins / puddings: -0.00700
granulated sugar: --
gravies: --
hard candy: -0.16000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --
Synonyms   Articles   Notes   Search   Top
Safety References:
Flavor & Extract Manufacturers Association (FEMA) reference(s):
The FEMA GRAS assessment of lactones used as flavor ingredients.View pdf
European Food Safety Athority(efsa): Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...
European Food Safety Authority (EFSA) reference(s):
Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) on a request from the Commission related to - Flavouring Group Evaluation 10: Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30 - (Commission Regulation (EC) No 1565/2000 of 18 July 2000)
View page or View pdf
Flavouring Group Evaluation 10, Revision 1 (FGE10 Rev1)[1] - Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC)
View page or View pdf
Scientific Opinion on Flavouring Group Evaluation 10, Revision 2 (FGE.10Rev2): Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30
View page or View pdf
EPI System: View
EPA Substance Registry Services (TSCA): 7779-50-2
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 3591866
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 2
Chemidplus: 0007779502
Synonyms   Articles   Notes   Search   Top
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 7779-50-2
Pubchem (cid): 3591866
Pubchem (sid): 135262953
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS): View
HMDB (The Human Metabolome Database): HMDB37805
Export Tariff Code: 2932.29.6000
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
Read: Under the conditions of intended use - New developments in the FEMA GRAS program and the safety assessment of flavor ingredients
Read: A GRAS assessment program for flavor ingredients
Read: Sensory testing for flavorings with modifying properties. Food Technology
Read: Criteria for the safety evaluation of flavoring substances
Read: A procedure for the safety evaluation of natural flavor complexes used as ingredients in food: essential oils
Read: FEMA Expert Panel: 30 Years of safety evaluation for the flavor industry
Read: Consumption ratio and food predominance of flavoring materials
Synonyms   Articles   Notes   Search   Top
Potential Blenders and core components note
 acetoxymethyl isolongifoleneFR
 acetyl cedreneFR
 allyl amyl glycolateFR
 allyl tiglateFL
 amber acetateFR
 amber butanolFR
 amber caraneFR
 amber carbinolFR
 amber cyclohexanolFR
 amber decaneFR
 amber dioxaneFR
 amber formateFR
 amber furanFR
 amber naphthofuranFL/FR
 amber oxepinFR
 amber pentadecaneFR
 amber spiroleneFR
 ambergris naphtholFR
 ambrene acetalFR
 ambrette seed oilFL/FR
 amyl benzoateFL/FR
isoamyl benzoateFL/FR
alpha-amyl cinnamaldehydeFL/FR
 amyl cinnamateFL/FR
isoamyl cinnamateFL/FR
isoamyl salicylateFL/FR
 amyris acetateFR
 amyris wood oilFL/FR
 angelica root oilFL/FR
 angelica seed oilFL/FR
 angelica seed oil CO2 extractFL/FR
 animal carbolactoneFR
para-anisyl acetateFL/FR
para-anisyl alcoholFL/FR
 armoise oilFR
 beeswax absoluteFL/FR
siam benzoin resinoidFL/FR
 benzyl acetateFL/FR
 benzyl cinnamateFL/FR
 benzyl propionateFL/FR
 benzyl salicylateFL/FR
 bergamot oilFL/FR
 berry hexanoateFR
 blackberry thiophenoneFL/FR
blood orange oil italyFL/FR
 bois de rose oil brazilFL/FR
laevo-bornyl acetateFL/FR
 buchu mercaptanFL/FR
 butyl benzoateFL/FR
isobutyl cinnamateFL/FR
 butyl hexanoateFL/FR
 butyl laurateFL/FR
isobutyl phenyl acetateFL/FR
isobutyl quinolineFR
isobutyl quinolineFR
isobutyl salicylateFL/FR
(+)-alpha-campholenic aldehydeFL/FR
 daucus carota fruit oilFL/FR
 cedar cyclododecatrieneFR
alpha-cedrene epoxideFR
 cedryl formateFR
 champaca absoluteFR
 magnolia flower oilFL/FR
 cinnamyl alcoholFL/FR
 cistus twig/leaf oilFL/FR
 clary sage absoluteFL/FR
 clary sage oil franceFL/FR
 clove bud oilFL/FR
 clover nitrileFR
 coriander seed oilFL/FR
 costus valerolactoneFR
para-cresyl caprylateFL/FR
black currant bud absoluteFL/FR
 cyclamen aldehydeFL/FR
 cyclohexyl crotonateFR
 cyclohexyl ethyl alcoholFL/FR
 cyperus root oil (cyperus rotundus)FR
 cypress absoluteFR
 artemisia pallens herb oilFL/FR
 decyl acetateFL/FR
 dewy propionateFR
 dimethyl benzyl carbinolFL/FR
 dimethyl benzyl carbinyl propionateFR
2,4-dimethyl thiazoleFL
 dodecanal (aldehyde C-12 lauric)FL/FR
 elecampane root oilFL
 ethyl 2-hydroxy-3-methyl valerateFL/FR
 ethyl 3-oxohexanoateFL
 ethyl cinnamateFL/FR
 ethyl laurateFL/FR
 ethyl maltolFL/FR
 ethyl methyl-para-tolyl glycidateFL/FR
 ethyl phenyl acetateFL/FR
 ethyl vanillinFL/FR
 ethylene brassylateFL/FR
isoeugenyl acetateFL/FR
 fir balsam absoluteFR
 floral pyranolFR
 formoxymethyl isolongifoleneFR
 frankincense oilFL/FR
 frankincense resinFL/FR
 gardenia oxideFR
 genet absoluteFL/FR
 geranyl acetateFL/FR
 geranyl benzoateFL/FR
 geranyl formateFL/FR
 grapefruit pentanolFR
 green acetateFR
 guaiacwood oilFL/FR
 guaiacyl phenyl acetateFL/FR
 guaiyl acetateFL/FR
 gurjun balsam oilFR
 hay absoluteFR
 heliotropyl acetoneFL/FR
 heliotropyl diethyl acetalFR
 heliotropyl isobutyrateFL/FR
 heptyl butyrateFL/FR
(Z)-3-hexen-1-yl 2-methyl butyrateFL/FR
(Z)-3-hexen-1-yl acetateFL/FR
(Z)-3-hexen-1-yl benzoateFL/FR
(Z)-3-hexen-1-yl propionateFL/FR
(Z)-3-hexen-1-yl salicylateFL/FR
alpha-hexyl cinnamaldehydeFL/FR
 hyacinth etherFR
 hydroxymethyl isolongifolene 50% in dpgFR
beta-ionone epoxideFL/FR
 juniper lactoneFL/FR
delta-juniper lactoneFL/FR
 labdanum absoluteFL/FR
 cistus leaf oilFR
 labdanum oilFL/FR
 cistus ladaniferus resinoidFR
 lavender absolute bulgariaFL/FR
(Z)-leaf acetalFL/FR
 linalool oxideFL/FR
 linalyl acetateFL/FR
 linalyl cinnamateFL/FR
isolongifolene ketoneFR
 mastic gum resinFR
 melon nonenoateFL/FR
 menthyl acetate racemicFL/FR
2-methoxy-4-vinyl phenolFL/FR
 methyl 2-methyl valerateFL/FR
para-methyl acetophenoneFL/FR
 methyl cedryl ketoneFL/FR
 methyl cinnamateFL/FR
 methyl dihydrojasmonateFL/FR
alpha-isomethyl ionone (90% min.)FL/FR
 methyl isoeugenolFL/FR
 methyl phenyl acetateFL/FR
2-methyl undecanal (aldehyde C-12 mna)FL/FR
2-methyl undecanal dimethyl acetalFR
 muguet carboxaldehydeFR
 muguet octadienolFR
 musk amberolFR
 musk ambretteCS
 musk lactoneFR
 musk methyl ketoneFR
 musk propanoateFR
 myrrh oilFL/FR
beta-naphthyl ethyl etherFL/FR
 oakmoss absoluteFL/FR
 ocean propanalFL/FR
(E)-2-octen-1-yl butyrateFL/FR
 opoponax absolute (commiphora erythraea var. glabrescens engle)FL/FR
 opoponax resinoid (commiphora erythraea var. glabrescens engle)FR
 orris pyridine 25% IPMFR
 osmanthus flower absoluteFL/FR
 patchouli ethanoneFR
 patchouli oilFL/FR
 peony alcoholFR
 phenethyl alcoholFL/FR
 phenethyl isobutyrateFL/FR
 phenethyl phenyl acetateFL/FR
 phenethyl propionateFL/FR
 phenethyl salicylateFL/FR
3-phenyl propyl alcoholFL/FR
isopropenyl acetateFL/FR
 propyl cinnamateFL/FR
isopropyl cinnamateFL/FR
 propyl formateFL/FR
 raspberry ketoneFL/FR
 raspberry ketone acetateFL/FR
 raspberry ketone methyl etherFL/FR
 rose butanoateFL/FR
 rose carboxylateFR
 rose petal acetateFR
 styralyl butyrateFL/FR
 styrax oil (liquidambar styraciflua)FL/FR
 styrax resinoid (liquidambar styraciflua)FL/FR
 tea acetateFR
 tobacarol (IFF)FR
 tolu balsamFL/FR
 tonka bean absoluteFR
 tricyclodecenyl isobutyrateFR
gamma-undecalactone (aldehyde C-14 (so-called))FL/FR
10-undecenal (aldehyde C-11 undecylenic)FL/FR
10-undecen-1-yl acetateFL/FR
 vanilla bean absolute (vanilla planifolia)FL/FR
 vanilla carboxylateFL/FR
 vanillyl acetateFL/FR
 verbena absolute franceFL/FR
 veramoss (IFF)FR
 vetiver oil haitiFL/FR
 violet leaf absoluteFL/FR
 violet methyl carbonateFR
 watermelon ketoneFR
 woody acetateFR
 woody cyclohexanoneFR
 woody dioxolaneFR
 woody epoxideFR
 woody etherFR
 woody nonane (ethoxy)FR
 woody propanolFR
Synonyms   Articles   Notes   Search   Top
Potential Uses:
 acacia cassie farnesianaFR
 apple crabapple 
 beeswax cire d'abeilleFL/FR
 cassia blossom 
 cedar forestFR
 champaca champakFR
 cherry blossomFR
 chocolate cacao 
 clover trefle le'trefle incarnatFR
 daffodil narcissusFR
 fantasy blends 
 fern fougereFR
 fir balsamFR
 fir needle pine needleFL/FR
 flouve blossom 
 forest pine forestFR
 frangipanni plumeriaFR
 fruit punch 
 fruit tropical fruit 
 genet genista broomFR
 ginger whiteFR
 grass sweetFR
 hay new mown hay foin coupeFR
 huckleberry bilberryFR
 immortelle helichrysum everlastingFL/FR
 kiwi blossom 
 licorice red licorice 
 loganberry dewberryFR
 meadow countryFR
 muguet lily of the valleyFR
 narcissus narcisseFR
 oakmoss mousse de chene mossFR
 ocean sea 
 orange blossomFR
 passion blossomFR
 passion fruitFR
 privet blossom 
 rain springFR
 reseda mignonetteFR
 rose d'orientFR
 rose redFR
 rose tea roseFR
 rose whiteFR
 rose wild rose 
 tonka beanFR
 wisteria wistaria glycineFR
 woodruff asperulaFR
Synonyms   Articles   Notes   Search   Top
Natural Occurrence in: note
 ambrette seed oil
GRIN Trop Picture
GRIN Trop Picture
 tea green tea
 wine white wine
Synonyms   Articles   Notes   Search   Top
16-hydroxy-6-hexadecenoic acid omega-lactone
Synonyms   Articles   Notes   Search   Top
Google Patents: Preparation of ambrettolide
PubMed: An automated headspace solid-phasemicroextraction followed by gas chromatography–mass spectrometry method to determine macrocyclic musk fragrances in wastewater samples.
PubMed: Efficient and selective formation of macrocyclic disubstituted Z alkenes by ring-closing metathesis (RCM) reactions catalyzed by Mo- or W-based monoaryloxide pyrrolide (MAP) complexes: applications to total syntheses of epilachnene, yuzu lactone, ambrettolide, epothilone C, and nakadomarin A.
PubMed: Fully automated determination of macrocyclic musk fragrances in wastewater by microextraction by packed sorbents and large volume injection gas chromatography-mass spectrometry.
PubMed: Copolymers from unsaturated macrolactones: toward the design of cross-linked biodegradable polyesters.
PubMed: [Studies on chemical constituents from Zephyranthes candida].
PubMed: Polymers from functional macrolactones as potential biomaterials: enzymatic ring opening polymerization, biodegradation, and biocompatibility.
PubMed: Two novel ceramides with a phytosphingolipid and a tertiary amide structure from Zephyranthes candida.
PubMed: Optimisation of a solid-phase microextraction method for synthetic musk compounds in water.
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Picture of molecule
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Soluble in:
 water, 0.5925 mg/L @ 25 °C (est)
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