EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

juniper lactone
hexadecano-1,16-lactone

Supplier Sponsors

Name:1-oxacycloheptadecan-2-one
CAS Number: 109-29-5Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:203-662-0
FDA UNII:64E2HO00C7
Nikkaji Web:J65.679H
Beilstein Number:0148631
MDL:MFCD00039668
XlogP3-AA:6.30 (est)
Molecular Weight:254.41350000
Formula:C16 H30 O2
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:flavor and fragrance agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
FLAVIS Number:10.047 (Old)
DG SANTE Food Flavourings:10.047 hexadecano-1,16-lactone
 
Physical Properties:
Appearance:colorless solid (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Refractive Index:1.46800 to 1.47300 @ 20.00 °C.
Melting Point: 34.00 °C. @ 760.00 mm Hg
Boiling Point: 358.13 °C. @ 760.00 mm Hg (est)
Vapor Pressure:0.000026 mmHg @ 25.00 °C. (est)
Flash Point:> 212.00 °F. TCC ( > 100.00 °C. )
logP (o/w): 6.650
Shelf Life: 36.00 month(s) or longer if stored properly.
Storage:store in cool, dry place in tightly sealed containers, protected from heat and light.
Soluble in:
 alcohol
 water, 0.04727 mg/L @ 25 °C (est)
Insoluble in:
 water
 
Organoleptic Properties:
Odor Type: musk
Odor Strength:medium ,
recommend smelling in a 10.00 % solution or less
Substantivity:400 hour(s) at 20.00 % in dipropylene glycol
sweet musk balsamic amber animal
Odor Description:at 10.00 % in dipropylene glycol. sweet musk balsam amber animal
Luebke, William tgsc, (1986)
Odor sample from: Charabot & Co., Inc.
Flavor Type: musk
musk cloth laundered cloth amber dry paper waxy animal
Taste Description: musk laundered cloth amber dry paper waxy animal
Odor and/or flavor descriptions from others (if found).
IFF
Hexadecanolide
Odor Description:Sweet musk note of great diffusion and tenacity with balsamic, animal effects
Taytonn
Hexadecanolide
Odor Description:Animalic/ Animal, Balsamic, Musk/ Musky, Sweet
Pell Wall Perfumes
Dihydroambrettolide
Odor Description:Musk, animalic, sweet, ambery, balsamic. Radiant and excellent fixative
Arctander says "DHA finds still some application in perfume compositions as a fixative with clean musky, slightly animal and foral undertones, and excellent performance in alcoholic solutions, and on the human skin. It may support delicate floral notes as well as typical Ambre notes or discrete Civet/animal tones, and it blends excellently with the purest Methylionones, Vetiver derivatives and aldehyde blends."
Taste Description:musk
Nactis Flavours
DIHYDROAMBRETTOLIDE
Odor Description:gives a unique topnote with a very fine character and a good diffusion
Taste Description:musk laundered cloth amber dry paper waxy animal
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: masking agents
perfuming agents
 
Suppliers:
A.C.S. International
Dihydroambrettolide Extra Pure
Odor: sweet musk balsamic amber
Operational Capabilities
A.C.S. International
Dihydroambrettolide
Odor: sweet musk balsamic amber
Associate Allied Chemicals
Dihydro Ambrettolide BM
About
Associate Allied Chemicals
Hexadecanolide
Azelis UK
HEXADECANOLIDE
Services
BOC Sciences
For experimental / research use only.
16-HEXADECANOLIDE 95%
Ernesto Ventós
DIHYDROAMBRETTOLIDE SYNAROME
Odor: MUSK,SWEET,ANIMAL,BALSAMIC
Ernesto Ventós
HEXADECANOLIDE IFF
Odor: MUSK,SWEET,ANIMAL,BALSAMIC
IFF
Hexadecanolide
Odor: Sweet musk note of great diffusion and tenacity with balsamic, animal effects
Indukern F&F
HEXADECANOLIDE
Odor: MUSK, SWEET, BALSAMIC, ANIMAL
Liaison Carbone
HEXADECANOLIDE
Lluch Essence
DIHYDRO AMBRETTOLIDE
Odor: MUSKY, ANIMALIC, SWEET
M&U International
Hexadecanolide(IFF# : 00082663)
Moellhausen
HEXADECANOLIDE DIHYDROAMBRETTOLIDE
Nactis Flavours
DIHYDROAMBRETTOLIDE
Odor: gives a unique topnote with a very fine character and a good diffusion
Pell Wall Perfumes
Dihydroambrettolide
Odor: Musk, animalic, sweet, ambery, balsamic. Radiant and excellent fixative
Use: Arctander says "DHA finds still some application in perfume compositions as a fixative with clean musky, slightly animal and foral undertones, and excellent performance in alcoholic solutions, and on the human skin. It may support delicate floral notes as well as typical Ambre notes or discrete Civet/animal tones, and it blends excellently with the purest Methylionones, Vetiver derivatives and aldehyde blends."
Penta International
HEXADECANOLIDE
Sigma-Aldrich
For experimental / research use only.
16-Hexadecanolide analytical standard
Soda Aromatic
Cetanolide
Stort Chemicals
Dihydroambrettolide
Taytonn
Hexadecanolide
Odor: Animalic/ Animal, Balsamic, Musk/ Musky, Sweet
The John D. Walsh Company
Hexadecanolide
 
Safety Information:
European information :
Most important hazard(s):
Xi - Irritant
R 38 - Irritating to skin.
S 02 - Keep out of the reach of children.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36 - Wear suitable protective clothing.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 > 5000 mg/kg
Food and Cosmetics Toxicology. Vol. 13, Pg. 452, 1975.

Dermal Toxicity:
skin-rabbit LD50 > 5000 mg/kg
Food and Cosmetics Toxicology. Vol. 13, Pg. 452, 1975.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: flavor and fragrance agents
Recommendation for juniper lactone usage levels up to:
  3.0000 % in the fragrance concentrate.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 0.024 (μg/capita/day)
Modified Theoretical Added Maximum Daily Intake (mTAMDI): 3900 (μg/person/day)
Threshold of Concern:1800 (μg/person/day)
Structure Class: I
 
Food categories according to Commission Regulation EC No. 1565/2000 (EC, 2000) in FGE.06 (EFSA, 2002a). According to the Industry the "normal" use is defined as the average of reported usages and "maximum use" is defined as the 95th percentile of reported usages (EFSA, 2002i).
Note: mg/kg = 0.001/1000 = 0.000001 = 1/1000000 = ppm.
 average usage mg/kgmaximum usage mg/kg
Dairy products, excluding products of category 02.0 (01.0): 7.0000035.00000
Fats and oils, and fat emulsions (type water-in-oil) (02.0): 5.0000025.00000
Edible ices, including sherbet and sorbet (03.0): 10.0000050.00000
Processed fruit (04.1): 7.0000035.00000
Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2): --
Confectionery (05.0): 10.0000050.00000
Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0): 5.0000025.00000
Bakery wares (07.0): 10.0000050.00000
Meat and meat products, including poultry and game (08.0): 2.0000010.00000
Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0): 2.0000010.00000
Eggs and egg products (10.0): --
Sweeteners, including honey (11.0): --
Salts, spices, soups, sauces, salads, protein products, etc. (12.0): 5.0000025.00000
Foodstuffs intended for particular nutritional uses (13.0): 10.0000050.00000
Non-alcoholic ("soft") beverages, excl. dairy products (14.1): 5.0000025.00000
Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2): 10.0000050.00000
Ready-to-eat savouries (15.0): 20.00000100.00000
Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0): 5.0000025.00000
 
Safety References:
European Food Safety Athority(efsa):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) on a request from the Commission related to - Flavouring Group Evaluation 10: Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30 - (Commission Regulation (EC) No 1565/2000 of 18 July 2000)
View page or View pdf

Flavouring Group Evaluation 10, Revision 1 (FGE10 Rev1)[1] - Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC)
View page or View pdf

Flavouring Group Evaluation 64 (FGE.64): Consideration of aliphatic acyclic diols, triols, and related substances evaluated by JECFA (57th meeting) structurally related to aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30 evaluated by EFSA in FGE.10Rev1 (EFSA, 2008ab)
View page or View pdf

Flavouring Group Evaluation 10, Revision 1 (FGE10 Rev1)[1] - Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC)
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 10, Revision 2 (FGE.10Rev2): Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 10, Revision 3 (FGE.10Rev3): Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30
View page or View pdf

EPI System: View
EPA Substance Registry Services (TSCA):109-29-5
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :7984
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
1-oxacycloheptadecan-2-one
Chemidplus:0000109295
RTECS:RN9730000 for cas# 109-29-5
 
References:
 1-oxacycloheptadecan-2-one
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:109-29-5
Pubchem (cid):7984
Pubchem (sid):134973671
Pherobase:View
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEMBL:View
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2932.99.9090
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
 
Potential Blenders and core components note
For Odor
aldehydic
dodecanal (aldehyde C-12 lauric)
FL/FR
amber
ambrette seed oil
FL/FR
ambroxan
FL/FR
angelica root oil
FL/FR
hydroxymethyl isolongifolene 50% in dpg
FR
animal
ambergris tincture replacer
FR
animal carbolactone
FR
iso
butyl quinoline
FR
costus valerolactone
FR
para-
cresyl caprylate
FL/FR
2-
methyl-4-(camphenyl-8) cyclohexanone
FR
anisic
para-
anisaldehyde
FL/FR
balsamic
amyl cinnamate
FL/FR
amyris wood oil
FL/FR
siam
benzoin resinoid
FL/FR
benzyl benzoate
FL/FR
benzyl cinnamate
FL/FR
benzyl salicylate
FL/FR
laevo-
bornyl acetate
FL/FR
butyl benzoate
FL/FR
iso
butyl cinnamate
FL/FR
cinnamyl alcohol
FL/FR
clover nitrile
FR
ethyl cinnamate
FL/FR
fir balsam absolute
FR
geranyl cinnamate
FR
methyl (E)-cinnamate
FL/FR
3-
phenyl propyl alcohol
FL/FR
tolu balsam
FL/FR
berry
raspberry ketone
FL/FR
raspberry ketone acetate
FL/FR
raspberry ketone methyl ether
FL/FR
caramellic
strawberry furanone
FL/FR
dusty
woody furan
FR
fatty
decanol
FL/FR
floral
amyl benzoate
FL/FR
iso
amyl salicylate
FL/FR
bois de rose oil brazil
FL/FR
citronellol
FL/FR
coriander seed oil
FL/FR
cyclamen aldehyde
FL/FR
cyclohexyl ethyl alcohol
FL/FR
dimethyl benzyl carbinol
FL/FR
floral pyranol
FR
geraniol
FL/FR
(E)-
geranyl acetone
FL/FR
heliotropin
FL/FR
heliotropyl diethyl acetal
FR
(Z)-3-
hexen-1-yl salicylate
FL/FR
alpha-
hexyl cinnamaldehyde
FL/FR
hyacinth ether
FR
hydroxycitronellal
FL/FR
leerall
FR
lilyall
FR
laevo-
linalool
FL/FR
linalool
FL/FR
linalool oxide
FL/FR
methyl dihydrojasmonate
FL/FR
muguet carboxaldehyde
FR
nerol
FL/FR
nerolidol
FL/FR
ocean propanal
FL/FR
orris pyridine 25% IPM
FR
phenethyl alcohol
FL/FR
phenethyl phenyl acetate
FL/FR
phenethyl salicylate
FL/FR
rhodinol
FL/FR
rose butanoate
FL/FR
fruity
allyl amyl glycolate
FR
gamma-
undecalactone (aldehyde C-14 (so-called))
FL/FR
green
(Z)-3-
hexen-1-yl benzoate
FL/FR
3-
phenyl propionaldehyde
FL/FR
hay
beeswax absolute
FL/FR
hay absolute
FR
herbal
clary sage oil france
FL/FR
daucus carota fruit oil
FL/FR
melon
watermelon ketone
FR
mossy
oakmoss absolute
FL/FR
veramoss (IFF)
FR
musk
homo
ambrinol
FR
ethylene dodecanoate
FR
musk amberol
FR
musk dec-7(8)-enone
FR
musk lactone
FR
naphthyl
beta-
naphthyl ethyl ether
FL/FR
powdery
para-
anisyl alcohol
FL/FR
spicy
benzyl isoeugenol
FL/FR
cuminaldehyde
FL/FR
nutmeg oil
FL/FR
terpenic
frankincense oil
FL/FR
alpha-
terpineol
FL/FR
thujonic
armoise oil
FR
tonka
coumarin
FR
tonka bean absolute
FR
vanilla
ethyl vanillin
FL/FR
vanilla bean absolute (vanilla planifolia)
FL/FR
vanillyl acetate
FL/FR
waxy
decyl acetate
FL/FR
1-
dodecanol
FL/FR
ethyl laurate
FL/FR
woody
amber carbinol
FR
cistus twig/leaf oil
FL/FR
guaiacwood oil
FL/FR
longifolene
FL/FR
methyl cedryl ketone
FL/FR
patchouli ethanone
FR
patchouli oil
FL/FR
santall
FR
tobacarol (IFF)
FR
vetiver oil CO2 extract
FL/FR
woody acetate
FR
woody propanol
FR
For Flavor
No flavor group found for these
amyl benzoate
FL/FR
butyl benzoate
FL/FR
methyl (E)-cinnamate
FL/FR
amber
amber
ambrette seed oil
FL/FR
animal
para-
cresyl caprylate
FL/FR
balsamic
amyl cinnamate
FL/FR
siam
benzoin resinoid
FL/FR
benzyl benzoate
FL/FR
benzyl salicylate
FL/FR
laevo-
bornyl acetate
FL/FR
iso
butyl cinnamate
FL/FR
ethyl cinnamate
FL/FR
styrax gum (liquidambar styraciflua)
FL
tolu balsam
FL/FR
berry
raspberry ketone
FL/FR
raspberry ketone acetate
FL/FR
raspberry ketone methyl ether
FL/FR
brown
beeswax absolute
FL/FR
caramellic
strawberry furanone
FL/FR
cherry
heliotropin
FL/FR
citrus
laevo-
linalool
FL/FR
linalool
FL/FR
nerol
FL/FR
alpha-
terpineol
FL/FR
creamy
para-
anisaldehyde
FL/FR
gamma-
undecalactone (aldehyde C-14 (so-called))
FL/FR
fatty
(Z)-3-
hexen-1-yl benzoate
FL/FR
floral
bois de rose oil brazil
FL/FR
citronellol
FL/FR
geraniol
FL/FR
(E)-
geranyl acetone
FL/FR
methyl dihydrojasmonate
FL/FR
ocean propanal
FL/FR
phenethyl alcohol
FL/FR
rhodinol
FL/FR
fruity
para-
anisyl alcohol
FL/FR
rose butanoate
FL/FR
green
iso
amyl salicylate
FL/FR
angelica root oil
FL/FR
cinnamyl alcohol
FL/FR
cyclamen aldehyde
FL/FR
cyclohexyl ethyl alcohol
FL/FR
(Z)-3-
hexen-1-yl salicylate
FL/FR
linalool oxide
FL/FR
nerolidol
FL/FR
oakmoss absolute
FL/FR
3-
phenyl propionaldehyde
FL/FR
herbal
clary sage oil france
FL/FR
coriander seed oil
FL/FR
daucus carota fruit oil
FL/FR
honey
phenethyl phenyl acetate
FL/FR
medicinal
dimethyl benzyl carbinol
FL/FR
phenethyl salicylate
FL/FR
powdery
beta-
naphthyl ethyl ether
FL/FR
soapy
dodecanal (aldehyde C-12 lauric)
FL/FR
1-
dodecanol
FL/FR
spicy
benzyl cinnamate
FL/FR
benzyl isoeugenol
FL/FR
cuminaldehyde
FL/FR
nutmeg oil
FL/FR
3-
phenyl propyl alcohol
FL/FR
vanilla
ethyl vanillin
FL/FR
vanilla bean absolute (vanilla planifolia)
FL/FR
vanillyl acetate
FL/FR
waxy
decanol
FL/FR
decyl acetate
FL/FR
ethyl laurate
FL/FR
alpha-
hexyl cinnamaldehyde
FL/FR
hydroxycitronellal
FL/FR
woody
ambroxan
FL/FR
amyris wood oil
FL/FR
cistus twig/leaf oil
FL/FR
frankincense oil
FL/FR
guaiacwood oil
FL/FR
longifolene
FL/FR
methyl cedryl ketone
FL/FR
patchouli oil
FL/FR
vetiver oil CO2 extract
FL/FR
 
Potential Uses:
FRaldehydic
FRamber
FRambergris
FRambrette oil replacer
FL/FRangelica
FRanimal
FRcrabapple
FRash mountain ash blossom
FRautumn
FRazalea
FRbalsam
FRbark
FRbayberry
FRblueberry
FRbouquet
FRbutter
FRcabreuva wood
FRcalamus oil replacer
FLcandy
FLcaramel
FRcarnation
FRcassia blossom
FRcedar
FRcedar forest
FRchampaca
FRchestnut blossom
FLchocolate cacao
FRchypre
FRcitrus
FRcivet
FRclean linen
FRclover
FRcoconut
FRcologne
FRcoronilla
FRcountry meadow
FRcrabapple blossom
FRcream
FRcyclamen
FRdaffodil
FRdahlia
FRdaisy
FRdaphne
 diffusion
FRdogwood
FReglantine
FRfagonia
FRfern
FRfig
FRfir balsam
 fixer
FRflouve blossom
FRfoliage
FRforest
FRfresh outdoors
FLfruit punch
FLfruit tropical fruit
FRgenet
FRginger white ginger
FRhabuba
FRhay new mown hay
FRherbal
FRhinoki oil replacer
FRhugonia
FRincense
FRkewda
FRlavender
FRleather
FRlily of the valley
FRlotus
FLmarshmallow
FRmimosa
FLmolasses
FRmoss
FRmusk
FRnarcissus
FLnut
FRoakwood
FRocean sea
FRoriental
FRpassion fruit
FLpear prickly pear
FRpetunia
FRphlox
FRpinion
FRpomegranate
FRpowder
FRrain
FRraspberry
FRrhubarb
FRrose d'orient
FRrose moss rose
FRrose white rose
FRsandalwood
FRscented stock
FRstephanotis
 straw
FRstrawberry
FRsweet grass
 timber
FRtobacco
FRtoffee
FRtulip
FL/FRvalerian
FRvanilla
FRwisteria
FRwoodruff
FRwoody
 
Occurrence (nature, food, other):note
 milk powder skim milk powder - 0.0145 mg/kg
Search PMC Picture
 
Synonyms:
 cetanolide
1-oxacycloheptadecan-2-one
oxacycloheptadecan-2-one
 cyclohexadecanolide
 cyclohexyl decanolide
 dihydro ambrettolide
 dihydroambrettolide
 dihydroambrettolide (cyclohexadecanolide )
1,16-hexadecalactone
 hexadecane-16-olide
 hexadecano-1,16-lactone
 hexadecanoic acid, 16-hydroxy-, .omicron.-lactone
 hexadecanoic acid, 16-hydroxy-, omicron-lactone
1,16-hexadecanolactone
16-hexadecanolactone
1,16-hexadecanolide
16-hexadecanolide
 hexadecanolide (IFF)
16-hydroxyhexadecanoic acid lactone
16-hydroxyhexadecanoic acid omicron-lactone
16-hydroxypalmitic-1,16-olide
 juniper lactone
 juniperic acid lactone
 juniperic acid, lactone
 juniperlactone
 
 
Notes:
None found
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