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2,4-dimethyl thiazole
2,4-dimethylthiazole

Sponsors

CAS Number: 541-58-2Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:208-786-9
FDA UNII:LHT97038OA
Nikkaji Web:J45.578D
Beilstein Number:0106414
MDL:MFCD00014509
CoE Number:11605
XlogP3-AA:1.80 (est)
Molecular Weight:113.18279000
Formula:C5 H7 N S
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:flavoring agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
FLAVIS Number:15.062 (Old)
DG SANTE Food Flavourings:15.062 2,4-dimethylthiazole
 
Physical Properties:
Appearance:colorless to pale yellow liquid to solid (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:1.05406 to 1.06500 @ 20.00 °C.
Pounds per Gallon - (est).: 8.781 to 8.872
Refractive Index:1.50200 to 1.51400 @ 20.00 °C.
Melting Point: 69.00 °C. @ 760.00 mm Hg
Boiling Point: 145.00 °C. @ 760.00 mm Hg
Vapor Pressure:5.080000 mm/Hg @ 25.00 °C.
Vapor Density:3.8 ( Air = 1 )
Flash Point: 121.00 °F. TCC ( 49.44 °C. )
logP (o/w): 0.361 (est)
Soluble in:
 alcohol
 water, 1750 mg/L @ 25 °C (est)
Insoluble in:
 water
 
Organoleptic Properties:
Odor Type: coffee
Odor Strength:high ,
recommend smelling in a 0.10 % solution or less
coffee tea beefy barley roasted barley
Odor Description:at 0.10 % in dipropylene glycol. coffee tea beefy roasted barley
Flavor Type: coffee
coffee
Taste Description: coffee
Odor and/or flavor descriptions from others (if found).
Treatt
2,4-Dimethylthiazole Kosher
Odor Description:coffee/tea, roast barley, meaty
Taste Description:coffee
Used in condiments, soups and sauces at 2-ppm, and in bakery and confection at 10ppm.
Taytonn
2,4-Dimethylthiazole
Odor Description:Meaty, Nutty, Roast
 
Cosmetic Information:
None found
 
Suppliers:
Anhui Suzhou Jinli Aromatic Chemicals
2,4-Dimethyl Thiazole
Odor: meat, coffee, cocoa
Beijing Lys Chemicals
2,4-Dimethylthiazole
BOC Sciences
For experimental / research use only.
2,4-Dimethyl Thiazole
DeLong Chemicals America
2,4-Dimethylthiazole, Kosher
Endeavour Specialty Chemicals
2,4-Dimethylthiazole 99% F&F
Speciality Chemical Product Groups
Jiangyin Healthway
2,4-Dimethyl thiazole
New functional food ingredients
Jinan Enlighten Chemical Technology(Wutong Aroma )
2,4-Dimethyl thiazole Kosherk
Lluch Essence
2,4-DIMETHYL TIAZOLE 95%
M&U International
2,4-DIMETHYL THIAZOLE, Kosher
Matrix Scientific
For experimental / research use only.
2,4-Dimethylthiazole, 97%
Penta International
2,4-DIMETHYLTHIAZOLE, Kosher
Reincke & Fichtner
2,4-Dimethylthiazole
Robinson Brothers
2,4-Dimethylthiazole F&F
https://www.robinsonbrothers.uk/chemistry-competences
Sigma-Aldrich
2,4-Dimethylthiazole, ≥95%, FG
Odor: meaty; coffee
Certified Food Grade Products
Sunaux International
2,4-Dimethyl Thiazole
Synerzine
2,4-Dimethylthiazole
Taytonn
2,4-Dimethylthiazole
Odor: Meaty, Nutty, Roast
TCI AMERICA
For experimental / research use only.
2,4-Dimethylthiazole >99.0%(GC)
Tengzhou Jitian Aroma Chemiclal
2,4-Dimethyl Thiazole
Tengzhou Xiang Yuan Aroma Chemicals
2,4-Dimethyl Thiazole
Treatt
2,4-Dimethylthiazole
Kosher
Odor: coffee/tea, roast barley, meaty
Flavor: coffee
Used in condiments, soups and sauces at 2-ppm, and in bakery and confection at 10ppm.
 
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
Xn - Harmful.
R 10 - Flammable.
R 22 - Harmful if swallowed.
R 36/37/38 - Irritating to eyes, respiratory system, and skin.
S 02 - Keep out of the reach of children.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50 250 mg/kg
National Technical Information Service. Vol. AD691-490

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: flavoring agents
Recommendation for 2,4-dimethyl thiazole usage levels up to:
 not for fragrance use.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 0.61 (μg/capita/day)
Modified Theoretical Added Maximum Daily Intake (mTAMDI): 140 (μg/person/day)
Threshold of Concern:540 (μg/person/day)
Structure Class: II
 
Food categories according to Commission Regulation EC No. 1565/2000 (EC, 2000) in FGE.06 (EFSA, 2002a). According to the Industry the "normal" use is defined as the average of reported usages and "maximum use" is defined as the 95th percentile of reported usages (EFSA, 2002i).
Note: mg/kg = 0.001/1000 = 0.000001 = 1/1000000 = ppm.
 average usage mg/kgmaximum usage mg/kg
Dairy products, excluding products of category 02.0 (01.0): 0.400002.00000
Fats and oils, and fat emulsions (type water-in-oil) (02.0): 0.200001.00000
Edible ices, including sherbet and sorbet (03.0): 0.400002.00000
Processed fruit (04.1): 0.300001.50000
Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2): --
Confectionery (05.0): 0.400002.00000
Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0): 0.200001.00000
Bakery wares (07.0): 0.400002.00000
Meat and meat products, including poultry and game (08.0): 0.100000.40000
Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0): 0.100000.40000
Eggs and egg products (10.0): --
Sweeteners, including honey (11.0): --
Salts, spices, soups, sauces, salads, protein products, etc. (12.0): 0.200001.00000
Foodstuffs intended for particular nutritional uses (13.0): 0.400002.00000
Non-alcoholic ("soft") beverages, excl. dairy products (14.1): 0.200001.00000
Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2): --
Ready-to-eat savouries (15.0): 1.000005.00000
Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0): 0.200001.00000
 
Safety References:
European Food Safety Athority(efsa):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Flavouring Group Evaluation 21: Thiazoles, thiophene, thiazoline and thienyl derivatives from chemical group 29. Miscellaneous substances from chemical group 30. (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf

Flavouring Group Evaluation 76, (FGE.76)[1] - Consideration of sulphur-containing heterocyclic compounds evaluated by JECFA (59th meeting) structurally related to thiazoles, thiophene, thiazoline and thienyl derivatives from chemical group 29, miscellaneous substances from chemical group 30 evaluated by EFSA in FGE.21 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food
View page or View pdf

Flavouring Group Evaluation 21, Revision 1 (FGE.21Rev1): Thiazoles, thiophene, thiazoline and thienyl derivatives from chemical group 29 Miscellaneous substances from chemical group 30
View page or View pdf

Flavouring Group Evaluation 93 (FGE.93): Consideration of sulphur heterocyclic evaluated by JECFA (68th meeting) structurally related to thiazoles, thiophene, thiazoline and thienyl evaluated by EFSA in FGE.21Rev1 (2009)
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 21, Revision 2 (FGE.21Rev2): Thiazoles, thiophene, thiazoline and thienyl derivatives from chemical group 29. Miscellaneous substances from chemical group 30.
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 21, Revision 3 (FGE.21Rev3): Thiazoles, thiophenes, thiazoline and thienyl derivatives from chemical groups 29 and 30
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 21, Revision 4 (FGE.21Rev4): Thiazoles, thiophenes, thiazoline and thienyl derivatives from chemical groups 29 and 30
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 21, Revision 5 (FGE.21Rev5): Thiazoles, thiophenes, thiazoline and thienyl derivatives from chemical groups 29 and 30
View page or View pdf

EPI System: View
Env. Mutagen Info. Center:Search
EPA Substance Registry Services (TSCA):541-58-2
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :10934
National Institute of Allergy and Infectious Diseases:Data
WISER:UN 1993
WGK Germany:3
2,4-dimethyl-1,3-thiazole
Chemidplus:0000541582
RTECS:XJ4375000 for cas# 541-58-2
 
References:
 2,4-dimethyl-1,3-thiazole
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:541-58-2
Pubchem (cid):10934
Pubchem (sid):134976129
Flavornet:541-58-2
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):HMDB32974
FooDB:FDB010961
Export Tariff Code:2934.10.9000
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
 
Potential Blenders and core components note
For Odor
alliaceous
methyl furfuryl disulfide
FL/FR
balsamic
2-
acetyl furan
FL/FR
guaiacyl phenyl acetate
FL/FR
guaiyl acetate
FL/FR
caramellic
coffee dione
FL/FR
cyclotene
FL/FR
chocolate
2,6-
dimethyl pyrazine
FL/FR
2-
methyl butyraldehyde
FL/FR
2,4,5-
trimethyl thiazole
FL/FR
2,4,5-
trimethyl thiazole
FL/FR
citrus
verbena absolute france
FL/FR
verbena absolute france
FL/FR
coffee
coffee difuran
FL/FR
furfuryl mercaptan
FL/FR
1-
hydroxy-2-butanone
FL/FR
2-
methyl-3-,5 or 6-(furfuryl thio) pyrazine
FL/FR
floral
geranyl formate
FL/FR
alpha-iso
methyl ionone (90% min.)
FL/FR
phenethyl isobutyrate
FL/FR
tetrahydrolinalool
FL/FR
fruity
heptyl butyrate
FL/FR
green
magnolia flower oil
FL/FR
herbal
6-
acetoxydihydrotheaspirane
FL/FR
clary sage absolute
FL/FR
clary sage oil france
FL/FR
theaspirane
FL/FR
theaspirane
FL/FR
wormwood oil america
FL/FR
wormwood oil america
FL/FR
yerba mate absolute
FL/FR
licorice
sweet
basil oleoresin
FL/FR
meaty
sulfurol
FL/FR
sulfuryl acetate
FL/FR
medicinal
2,6-
xylenol
FL/FR
2,6-
xylenol
FL/FR
mentholic
menthyl acetate
FL/FR
menthyl acetate racemic
FL/FR
musty
menthofuran
FL/FR
ketoiso
phorone
FL/FR
nutty
3,5-
cocoa pyrazine
FL/FR
2,3-
dimethyl pyrazine
FL/FR
4,5-
dimethyl-2-ethyl-3-thiazoline
FL/FR
filbert heptenone
FL/FR
5-
methyl quinoxaline
FL/FR
2-
methyl thio-3,5 or 6-methyl pyrazine
FL/FR
2,3,5,6-
tetramethyl pyrazine
FL/FR
popcorn
2-
acetyl pyrazine
FL/FR
spicy
(-)-
cubenol
FL/FR
sulfurous
benzothiazole
FL/FR
furfuryl thioacetate
FL/FR
S-
furfuryl thioformate
FL/FR
2-
methyl 5-(methyl thio) furan
FL/FR
tropical
genet absolute
FL/FR
vegetable
1-
furfuryl pyrrole
FL/FR
For Flavor
No flavor group found for these
6-
acetoxydihydrotheaspirane
FL/FR
2,5-
dimethyl-3-thiofuroyl furan
FL
guaiyl acetate
FL/FR
magnolia flower oil
FL/FR
menthyl acetate racemic
FL/FR
2-
methyl-3-,5 or 6-(furfuryl thio) pyrazine
FL/FR
1-(2-
thienyl) butanone
FL
1-(2-
thienyl) butanone
FL
alliaceous
alliaceous
benzyl mercaptan
FL
dicyclohexyl disulfide
FL
brown
1-
hydroxy-2-butanone
FL/FR
burnt
furfuryl alcohol
FL
2-
methyl quinoxaline
FL
2,6-
xylenol
FL/FR
2,6-
xylenol
FL/FR
caramellic
caramel furanone
FL
cyclotene
FL/FR
citrus
ketoiso
phorone
FL/FR
verbena absolute france
FL/FR
verbena absolute france
FL/FR
coffee
coffee difuran
FL/FR
coffee dione
FL/FR
coffee pyrazine
FL
difurfuryl ether
FL
diisoamyl thiomalate
FL
furfuryl mercaptan
FL/FR
methyl furfuryl disulfide
FL/FR
2-
thiophene thiol
FL
2-
thiophene thiol
FL
cooling
menthyl acetate
FL/FR
theaspirane
FL/FR
theaspirane
FL/FR
earthy
difurfuryl sulfide
FL
floral
alpha-iso
methyl ionone (90% min.)
FL/FR
tetrahydrolinalool
FL/FR
fruity
furfuryl propionate
FL
fusel
2-
methyl butyraldehyde
FL/FR
green
clary sage absolute
FL/FR
geranyl formate
FL/FR
heptyl butyrate
FL/FR
2-
methyl-5-isopropyl pyrazine
FL
hay
genet absolute
FL/FR
herbal
clary sage oil france
FL/FR
wormwood oil america
FL/FR
wormwood oil america
FL/FR
yerba mate absolute
FL/FR
honey
phenethyl isobutyrate
FL/FR
licorice
sweet
basil oleoresin
FL/FR
meaty
benzothiazole
FL/FR
3-
mercapto-2-butanone
FL
2-
methyl 3-(methyl thio) furan
FL
2-
methyl-3-tetrahydrofuran thiol
FL
2-
pyridinyl methane thiol
FL
sulfurol
FL/FR
sulfuryl acetate
FL/FR
mustard
furfuryl methyl ether
FL
musty
menthofuran
FL/FR
2-
methyl 5-(methyl thio) furan
FL/FR
nutty
2-
acetyl furan
FL/FR
3,5(6)-
cocoa pyrazine
FL
3,5-
cocoa pyrazine
FL/FR
2,6-
dimethyl pyrazine
FL/FR
2,3-
dimethyl pyrazine
FL/FR
4,5-
dimethyl-2-ethyl-3-thiazoline
FL/FR
filbert heptenone
FL/FR
5-
methyl quinoxaline
FL/FR
2-
methyl thio-3,5 or 6-methyl pyrazine
FL/FR
2,3,5,6-
tetramethyl pyrazine
FL/FR
2,4,5-
trimethyl thiazole
FL/FR
2,4,5-
trimethyl thiazole
FL/FR
onion
furfuryl isopropyl sulfide
FL
phenolic
guaiacyl phenyl acetate
FL/FR
roasted
2-
acetyl pyrazine
FL/FR
ethyl 3-(furfuryl thio) propionate
FL
furfuryl thioacetate
FL/FR
spicy
(-)-
cubenol
FL/FR
sulfurous
butyl mercaptan
FL
ethyl methyl sulfide
FL
S-
ethyl thioacetate
FL
S-
furfuryl thioformate
FL/FR
furfuryl thiopropionate
FL
3-
methyl-2-butane thiol
FL
2-
thienyl mercaptan
FL
2-
thienyl mercaptan
FL
vegetable
1-
furfuryl pyrrole
FL/FR
 
Potential Uses:
FLbarley
 chocolate cocoa
FLcoffee
FLnut
FLtea
 
Occurrence (nature, food, other):note
 barley roasted barley
Search Trop Picture
 beef cooked beef
Search PMC Picture
 bonito
Search PMC Picture
 coffee
Search PMC Picture
 passion fruit juice
Search Trop Picture
 pea southern pea
Search PMC Picture
 pork grilled, roasted pork - up to 0.00004 mg/kg
Search PMC Picture
 shell fish
Search PMC Picture
 tea black tea
Search Trop Picture
 tea leaf
Search Trop Picture
 
Synonyms:
2,4-dimethyl-1,3-thiazole
2,4-dimethyl-thiazole
2,4-dimethylthiazole
2,4-methyl thiazole
 thiazole, 2,4-dimethyl-
 

Articles:

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Notes:
Constit. of beef aroma
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