sclareol
  • Advanced Biotech
  • Beijing Lys Chemicals
    • Beijing Lys Chemicals Co, LTD.
      From Grams to Tons
      Fine chemical high-tech company which contains R&D, production, and sales.
      BEIJING LYS CHEMICALS CO, LTD, established in 2004, is a fine chemical high-tech company which contains R&D, production, and sales. We mainly engaged in export and technology development of flavor and fragrance materials and pharmaceutical intermediates. We have nearly 500 kinds of products, from grams to tons, exported to USA, Europe, South Asia and etc. And we custom manufacture new products according to customers’ needs, and serve good quality products and service. Our goal is to become a fine chemical enterprise which could provide special products and services.
      Email: Mr. Jia
      Email: Mr. Guo
      Voice: 86-10-68418738
      Fax: 86-10-68418739
      Mr. Guo86-10-68483445
      Mr. Guo86-10-68418739
      Product(s):
      20017 Natural sclareol
       
  • Berjé
    • Berjé Inc.
      The solution is clear
      Where the world comes to its senses - Berjé is a global distributor of Essential Oils and Aromatic Chemicals.
      Berjé is a family-owned business that has been in operation for six decades. The company's origins and strength lie in a profound understanding of the supply and the quality of the diverse raw materials consumed by the flavor and fragrance industries. This base was expanded upon more than two decades ago to include fragrance production. The company's unparalleled raw material expertise is focused on the supply of essential oils and aromatic chemicals. This is supported by our long-standing relationships with a worldwide fabric of producers ensuring the greatest prospects for uninterrupted supply in markets that are often volatile and unpredictable.
      Email: For Information
      Email: For Sales
      Voice: 973-748-8980
      Fax: 973-680-9618
      Product(s):
      Sclareol
       
  • Fleurchem
    • Fleurchem, Inc.
      Have A Flavorful Day
      A leading global manufacturer and supplier of ingredients for Flavors, Fragrances, AromaTherapy, Foods, Beverages, Personal Care Products, and other uses.
      Operating out of the 200,000 sq. ft., former Hercules/PFW facility in Middletown, NY; Fleurchem produces a full range of natural isolates, synthetic chemicals & specialities, essential oils and flavors. Additionally, the company performs toll manufacturing, as well as custom chemical synthesis for a wide range of clients.
      Email: Information
      US Voice: 845-341-2100
      US Fax: 845-341-2121
      Product(s):
      sclareol natural
       
  • H. Interdonati, Inc.
    • H. Interdonati, Inc.
      Innovative products
      Because your flavors and fragrances are only as good as their source "Since 1952"
      H. Interdonati, Inc. began in 1952 with the tradition of delivering quality pharmaceuticals and fine chemical ingredients at competitive prices. The mission was simple: To provide the most reliable, personal service in the industry.
      Email: Info
      US Email: Info
      Email: Sales
      US Email: Andrew Interdonati (Sales)
      Voice: 800 367-6617
      Fax: 631 367-6626
      Product(s):
      Sclareol Natural, Kosher
       
  • M&U International
    • M&U International LLC
      Steady supply & demand
      Meeting customers increasing demands at home as well as abroad.
      M&U dedicates itself to the development and production of new products as well as continuously promoting those new products. We’ve maintained a steady supply&demand relationship with a large number of manufacturers at home and abroad. We’ve developed an extensive network and because of our relationships with these manufacturers, we’re able to provide a stable supply of great quality materials. We’re located in China’s largest communications hub, Shanghai and in the U.S. near one of the largest sea ports on the East Coast. The strategic locations of our facilities ensure convenient, prompt and secure delivery of our products to our customers. We warmly welcome your inquiries, come witness our solemn commitment for yourself.
      Email: Sales
      US Email: Sales
      Voice: +86-21-32515501 60762991 60762992
      Fax: +86-21-32515502 64204960
      US Voice: 908-359-9000
      US Fax: 908-359-9002
      Product(s):
      A0135 SCLAREOL, Kosher
       
  • Penta International
    • Penta International Corporation
      Chemistry innovation
      At Penta, our products and services help businesses do business better.
      For over 30 years, Penta Manufacturing Company has played a growing role in worldwide chemistry innovations and applications. As an industry leader, Penta continues to pioneer chemistry-based solutions for practically every area of commerce. Our products and expertise have helped fuel technical advances in dozens of commercial applications including flavoring, coloring, fragrances and chemical processes.
      US Email: Technical Services
      US Email: Sales
      US Voice: (973) 740-2300
      US Fax: (973) 740-1839
      Product(s):
      19-12000 SCLAREOL, Kosher
      19-12001 SCLAREOL NATURAL, Kosher
       
  • Sunaux International
    • Sunaux International
      Buy With Confidence
      We have industry leading processes and procedures to ensure nothing but the most reliable product.
      Sunaux International was founded in 2012 by the owner Mr.John Felton after spending 18 years involved in developing global business in the aromatic chemicals, fragrance and flavour compounds business.
      Email: John Felton
      Email: Stephen Zhou (Sales)
      Voice: 0512-57995626
      Fax: 0512-57570299
      Sales0512-57995626
      Sales0512-57570299
      Product(s):
      A0146 Sclareol
       
  • Ultra International
    • Ultra International
      Driven by a mutual passion for excellence.
      Ultra International is one of the leading company in the Flavors and Fragrance industry.
      Ultra International is one of the leading company in the Flavors and Fragrance industry with a vision to be the Essential Source of Sensory Innovation for customers, driven by a mutual passion for excellence. Through unique sensory expertise and consumer insight, Ultra provides customers with the taste and smell profiles that are key to their products' success. Our passion for Perfumes and Flavors, our Creativity and Innovation, together with our exceptional understanding of sensory perceptions and trends, have forged our world-class reputation.
      Email: Ravi Sanganeria (General enquiries)
      Email: Bhuvana Nageshwaran (Sales)
      Voice: 91-9810011601
      Fax: 91-11-4151 7050
      Ravi Sanganeria:91-11-41517010
      Products List: View
      Product(s):
      Sclareol Russian/Ukrainian
       
  • Ernesto Ventós
 
Synonyms   Articles   Notes   Search
Fragrance Demo Formulas
(1R,2R,8aS)-1-[(3R)-3-hydroxy-3-methylpent-4-enyl]-2,5,5,8a-tetramethyl-3,4,4a,6,7,8-hexahydro-1H-naphthalen-2-ol (Click)
CAS Number: 515-03-7 17904-64-2
ECHA EC Number: 208-194-0
FDA UNII: B607NP0Q8Y
Beilstein Number: 2054148
MDL: MFCD00869558
FEMA Number: 4502
CoE Number: 10311
XlogP3-AA: 4.90 (est)
Molecular Weight: 308.50532000
Formula: C20 H36 O2
NMR Predictor: Predict
(1R,2R,4aS,8aS)-1-[(3R)-3-hydroxy-3-methylpent-4-enyl]-2,5,5,8a-tetramethyl-3,4,4a,6,7,8-hexahydro-1H-naphthalen-2-ol (Click)
CAS Number: 515-03-7  (RRS)
XlogP3-AA: 4.90 (est)
Molecular Weight: 308.50532000
Formula: C20 H36 O2
BioActivity Summary: listing
NMR Predictor: Predict
Category: flavor and fragrance agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist: Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
JECFA Food Flavoring: 2029  (-)-sclareol
Flavis Number: 02.206 (Old)
EU SANCO Food Flavourings: 02.206  (-)-sclareol

FEMA Number: 4502  (-)-sclareol
FDA Mainterm: (-)-SCLAREOL
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Physical Properties:
Appearance: amber solid (est)
Assay: 98.00 to 100.00 % sum of isomers
Food Chemicals Codex Listed: No
Melting Point: 105.00 to  107.00 °C. @ 760.00 mm Hg
Boiling Point: 218.00 to  220.00 °C. @ 19.00 mm Hg
Flash Point: 336.00 °F. TCC ( 169.10 °C. ) (est)
logP (o/w): 5.233 (est)
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Organoleptic Properties:
Odor Type: balsamic
Odor Strength: low
Odor Description:
at 100.00 %. 
sweet balsam clary amber woody weedy
Luebke, William tgsc, (1988)
Odor sample from: RJR Technical Company
Substantivity: 292 Hour(s)
  
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: perfuming agents
Synonyms   Articles   Notes   Search   Top
Suppliers:
Advanced Biotech
sclareol natural
98% min.
Odor: Musky, Woody
Beijing Lys Chemicals
Natural sclareol
Berjé
Sclareol
Ernesto Ventós
SCLAREOL NATURAL
ExtraSynthese
Sclareol
For experimental / research use only.
Fleurchem
sclareol natural
H. Interdonati, Inc.
Sclareol Natural, Kosher
M&U International
SCLAREOL, Kosher
Penta International
SCLAREOL NATURAL, Kosher
Penta International
SCLAREOL, Kosher
Reincke & Fichtner
Sclareol natural
Sigma-Aldrich: Aldrich
Sclareol
For experimental / research use only.
Sunaux International
Sclareol
Ultra International
Sclareol Russian/Ukrainian
Zhejiang Taizhou TU-POLY
Sclareol
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Safety Information:
European information :
Most important hazard(s):
None - None found.
  S 02 - Keep out of the reach of children.
S 24/25 - Avoid contact with skin and eyes.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
  oral-rat LD50  > 5000 mg/kg
Food and Chemical Toxicology. Vol. 30, Pg. 115S, 1992.

Dermal Toxicity:
  skin-rabbit LD50 > 5000 mg/kg
Food and Chemical Toxicology. Vol. 30, Pg. 115S, 1992.

Inhalation Toxicity:
  Not determined
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Safety in Use Information:
0.0008 mg/kg/day (IFRA, 2004)
Category: flavor and fragrance agents
Maximised Survey-derived Daily Intakes (MSDI-EU): 0.67 (μg/capita/day)
Modified Theoretical Added Maximum Daily Intake (mTAMDI): 3900 (μg/person/day)
Threshold of Concern:1800 (μg/person/day)
Structure Class: I
IFRA Critical Effect: Sensitization
IFRA Purity Specification: 98% minimum purity
IFRA fragrance material specification:
 Sclareol used as a fragrance ingredient should have a minimum purity of 98%.
IFRA: View Standard
maximum skin levels for fine fragrances:
  0.0200 %  and are based on the assumption that the fragrance mixture is used at 20% in a consumer product (IFRA Use Level Survey). (IFRA, 2004)
Recommendation for sclareol usage levels up to:
  4.0000 % in the fragrance concentrate.
use level in formulae for use in cosmetics:
  0.0300 %
Dermal Systemic Exposure in Cosmetic Products:
 
 
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA on the "Resources" link.
publication number: 24
 average usual ppmaverage maximum ppm
baked goods: 10.0000050.00000
beverages(nonalcoholic): 5.0000025.00000
beverages(alcoholic): 5.0000025.00000
breakfast cereal: 5.0000025.00000
cheese: 7.0000035.00000
chewing gum: --
condiments / relishes: 20.00000100.00000
confectionery froastings: 10.0000050.00000
egg products: --
fats / oils: 5.0000025.00000
fish products: 2.0000010.00000
frozen dairy: 7.0000035.00000
fruit ices: 10.0000050.00000
gelatins / puddings: 10.0000050.00000
granulated sugar: --
gravies: 5.0000025.00000
hard candy: 10.0000050.00000
imitation dairy: 7.0000035.00000
instant coffee / tea: 5.0000025.00000
jams / jellies: 7.0000035.00000
meat products: 2.0000010.00000
milk products: 7.0000035.00000
nut products: 5.0000025.00000
other grains: 5.0000025.00000
poultry: 2.0000010.00000
processed fruits: 7.0000035.00000
processed vegetables: 7.0000035.00000
reconstituted vegetables: 7.0000035.00000
seasonings / flavors: 5.0000025.00000
snack foods: 10.0000050.00000
soft candy: 10.0000050.00000
soups: 5.0000025.00000
sugar substitutes: --
sweet sauces: 5.0000025.00000
 
Food categories according to Commission Regulation EC No. 1565/2000 (EC, 2000) in FGE.06 (EFSA, 2002a). According to the Industry the "normal" use is defined as the average of reported usages and "maximum use" is defined as the 95th percentile of reported usages (EFSA, 2002i).
Note: mg/kg = 0.001/1000 = 0.000001 = 1/1000000 = ppm.
 average usage mg/kgmaximum usage mg/kg
Dairy products, excluding products of category 02.0 (01.0): 7.0000035.00000
Fats and oils, and fat emulsions (type water-in-oil) (02.0): 5.0000025.00000
Edible ices, including sherbet and sorbet (03.0): 10.0000050.00000
Processed fruit (04.1): 7.0000035.00000
Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2): --
Confectionery (05.0): 10.0000050.00000
Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0): 5.0000025.00000
Bakery wares (07.0): 10.0000050.00000
Meat and meat products, including poultry and game (08.0): 2.0000010.00000
Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0): 2.0000010.00000
Eggs and egg products (10.0): --
Sweeteners, including honey (11.0): --
Salts, spices, soups, sauces, salads, protein products, etc. (12.0): 5.0000025.00000
Foodstuffs intended for particular nutritional uses (13.0): 10.0000050.00000
Non-alcoholic ("soft") beverages, excl. dairy products (14.1): 5.0000025.00000
Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2): 10.0000050.00000
Ready-to-eat savouries (15.0): 20.00000100.00000
Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0): 5.0000025.00000
Synonyms   Articles   Notes   Search   Top
Safety References:
European Food Safety Athority(efsa): Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...
European Food Safety Authority (EFSA) reference(s):
Flavouring Group Evaluation 18, Revision 1 (FGE. 18 Rev1)[1] : Aliphatic, alicyclic and aromatic saturated and unsaturated tertiary alcohols, aromatic tertiary alcohols and their esters from chemical groups 6 and 8
page or pdf
Scientific Opinion on Flavouring Group Evaluation 90 (FGE.90): Consideration of Aliphatic, acyclic and alicyclic terpenoid tertiary alcohols and structurally related substances evaluated by JECFA (68th meeting)FGE.18Rev1 (2009)
page or pdf
Scientific Opinion on Flavouring Group Evaluation 18, Revision 2 (FGE.18Rev2): Aliphatic, alicyclic and aromatic saturated and unsaturated tertiary alcohols, aromatic tertiary alcohols and their esters from chemical groups 6 and 8.
page or pdf
Scientific Opinion on Flavouring Group Evaluation 18, Revision 3 (FGE.18Rev3): Aliphatic, alicyclic and aromatic saturated and unsaturated tertiary alcohols, aromatic tertiary alcohols and their esters from chemical groups 6 and 8.
page or pdf
EPI System: View
Chemicalize.org: Calculate predicted properties
Cancer Citations: Search
EPA Substance Registry Services (TSCA): 515-03-7
EPA ACToR: Toxicology Data
National Institute of Allergy and Infectious Diseases: Data
SCCNFP: opinion
WGK Germany: 2
 (1R,2R,8aS)-1-[(3R)-3-hydroxy-3-methylpent-4-enyl]-2,5,5,8a-tetramethyl-3,4,4a,6,7,8-hexahydro-1H-naphthalen-2-ol
Chemidplus: 0000515037
RTECS: QK0301900 for cas# 515-03-7
 (1R,2R,4aS,8aS)-1-[(3R)-3-hydroxy-3-methylpent-4-enyl]-2,5,5,8a-tetramethyl-3,4,4a,6,7,8-hexahydro-1H-naphthalen-2-ol
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References:
 (1R,2R,8aS)-1-[(3R)-3-hydroxy-3-methylpent-4-enyl]-2,5,5,8a-tetramethyl-3,4,4a,6,7,8-hexahydro-1H-naphthalen-2-ol
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 515-03-7
Pubchem (cid): 73114
Pubchem (sid): 135029099
 (1R,2R,4aS,8aS)-1-[(3R)-3-hydroxy-3-methylpent-4-enyl]-2,5,5,8a-tetramethyl-3,4,4a,6,7,8-hexahydro-1H-naphthalen-2-ol
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 515-03-7
Pubchem (cid): 163263
Pubchem (sid): 46237757
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS): View
CHEBI: View
CHEMBL: View
Export Tariff Code: 2906.19.0000
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
FAO: (-)-Sclareol
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Potential Blenders and core components note
 acetoxymethyl isolongifoleneFR
 amber butanolFR
 amber caraneFR
 amber cyclohexanolFR
 amber decaneFR
 amber decatrieneFR
 amber dioxaneFR
 amber formateFR
 amber furanFR
 amber naphthofuranFL/FR
 amber oxepinFR
 amber pentadecaneFR
 amber spiroleneFR
 ambergris naphtholFR
 ambrene acetalFR
 ambrette seed absoluteFL/FR
 ambrinolFR
 ambroxanFL/FR
 animal carbolactoneFR
4-tert-butyl cyclohexane carboxaldehydeFR
beta-caryophyllene alcohol acetateFL/FR
 cedarwood oil texasFR
alpha-cedrene epoxideFR
 cedrenyl acetateFR
 cedrol methyl etherFR
 cedryl acetateFL/FR
 cistus twig/leaf oilFL/FR
(Z)-civet decenoneFL/FR
 clary acetateFR
 clary octenoneFR
 clary propyl acetateFR
 clary sage oil franceFL/FR
 clary sage resin americaFR
 cyclohexadecanoneFR
 cyclohexyl crotonateFR
 decanal / methyl anthranilate schiff's baseFR
 dihydro-beta-iononeFL/FR
 elecampane root oilFL
 formoxymethyl isolongifoleneFR
 grapefruit oil c.p. californiaFL/FR
 heliotropinFL/FR
 hydroxymethyl isolongifolene 50% in dpgFR
 juniper lactoneFL/FR
 labdanum absoluteFL/FR
 mastic absoluteFL/FR
alpha-methyl iononeFL/FR
 musk methyl ketoneFR
bitter orange peel oil brazilFL/FR
omega-pentadecalactoneFL/FR
 sclarene 
 sclareolideFL/FR
 tetradecanalFL/FR
 verdoxanFR
 timber propanolFR
 tobacco butenalFR
 tobacarolFR
 tobacco leaf absoluteFL/FR
 tobacco noneneFR
 treemoss absoluteFR
 valenceneFL/FR
 veramossFR
 woody carboxylateFR
 woody cyclohexanoneFR
 woody dioxolaneFR
 woody epoxideFR
 woody etherFR
 woody nonane (ethoxy)FR
 woody propanolFR
Synonyms   Articles   Notes   Search   Top
Potential Uses:
 amberFR
 balsamFR
 clary sageFL/FR
 orientalFR
 woodyFR
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Natural Occurrence in: note
 clary sage oil france @ 0.10-0.20%
Data  GC  GRIN Trop Picture
 clary sage oil greece @ 5.20%
Data  GC  GRIN Trop Picture
 clary sage oil spain @ 0.45%
Data  GC  GRIN Trop Picture
 salvia atropatana bunge oil iran @ 13.30%
Data  GC  GRIN Trop Picture
 salvia sclarea l.
GRIN Trop Picture
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Synonyms:
alpha-ethenyl decahydro-2-hydroxy-a,2,5,5,8a-pentamethyl(1R-(1alpha(R*),2beta,4abeta,8H
(1theta- (1alpha (theta),2beta, 4abeta,8aalpha))-alpha-ethenyl decahydro-2-hydroxy-alpha,2,5,5,8a-pentamethyl-1-naphthalene propanol
(1r,2r,8as)-1-[(3R)-3-hydroxy-3-methylpent-4-en-1-yl]-2,5,5,8a-tetramethyldecahydronaphthalen-2-ol
(1R,2R,8aS)-1-[(3R)-3-hydroxy-3-methylpent-4-enyl]-2,5,5,8a-tetramethyl-3,4,4a,6,7,8-hexahydro-1H-naphthalen-2-ol
(1R-(1alpha(R*), 2beta,4abeta, 8aalpha))-2-hydroxy-alpha,2,5,5,8a-pentamethyl-alpha-vinyl decahydronaphthalene-1-propan-1-ol
(13R)-labd-14-ene-8,13-diol
 labd-14-ene-8,13-diol, (13R)-
1-naphthalenepropanol, a-ethenyldecahydro-2-hydroxy-a,2,5,5,8a-pentamethyl-, (aR,1R,2R,4aS,8aS)-
(-)-sclareol
 sclareol natural
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Articles:
PubMed: Characterization of two genes for the biosynthesis of abietane-type diterpenes in rosemary (Rosmarinus officinalis) glandular trichomes.
PubMed: [Engineering Saccharomyces cerevisiae for sclareol production].
PubMed: [Preface for special issue on synthetic biology (2013)].
PubMed: Sclareol reduces CD4+ CD25+ FoxP3+ Treg cells in a breast cancer model in vivo.
PubMed: Hh signaling inhibitors from Vitex negundo; naturally occurring inhibitors of the GLI1-DNA complex.
PubMed: Chemical composition and anticancer activity of essential oils of Mediterranean sage (Salvia officinalis L.) grown in different environmental conditions.
PubMed: Extracellular localization of the diterpene sclareol in clary sage (Salvia sclarea L., Lamiaceae).
PubMed: Bioactive constituents of Salvia chrysophylla Stapf.
PubMed: Toward a biosynthetic route to sclareol and amber odorants.
PubMed: Enzymatic biotransformation of terpenes as bioactive agents.
PubMed: A diterpene synthase from the clary sage Salvia sclarea catalyzes the cyclization of geranylgeranyl diphosphate to (8R)-hydroxy-copalyl diphosphate.
PubMed: Cancer cell spheroids as a model to evaluate chemotherapy protocols.
PubMed: Discovery and functional characterization of two diterpene synthases for sclareol biosynthesis in Salvia sclarea (L.) and their relevance for perfume manufacture.
PubMed: Identification of natural diterpenes that inhibit bacterial wilt disease in tobacco, tomato and Arabidopsis.
PubMed: Sclareol exhibits anti-inflammatory activity in both lipopolysaccharide-stimulated macrophages and the λ-carrageenan-induced paw edema model.
PubMed: Antimicrobial evaluation of diterpenes from Copaifera langsdorffii oleoresin against periodontal anaerobic bacteria.
PubMed: First enantiospecific synthesis of marine sesquiterpene quinol akaol A.
PubMed: Four potato (Solanum tuberosum) ABCG transporters and their expression in response to abiotic factors and Phytophthora infestans infection.
PubMed: Synthesis of the scalarane sesterterpenoid 16-deacetoxy-12-epi-scalarafuranacetate.
PubMed: The labdane diterpene sclareol (labd-14-ene-8, 13-diol) induces apoptosis in human tumor cell lines and suppression of tumor growth in vivo via a p53-independent mechanism of action.
PubMed: Isolation, chemical, and biotransformation routes of labdane-type diterpenes.
PubMed: Chemical composition and antimicrobial activity of the essential oils from Cleome spinosa.
PubMed: Sclareol modulates the Treg intra-tumoral infiltrated cell and inhibits tumor growth in vivo.
PubMed: Mitochondria-targeted liposomes improve the apoptotic and cytotoxic action of sclareol.
PubMed: Hemisynthesis of two marine cheilanthane sesterterpenes from (-)-sclareol: first enantioselective synthesis of petrosaspongiolide R.
PubMed: Fragrance material review on sclareol.
PubMed: Diversity of essential oil glands of clary sage (Salvia sclarea L., Lamiaceae).
PubMed: Microbial hydroxylation of sclareol by Rhizopus stolonifer.
PubMed: Cell growth inhibitory action of an unusual labdane diterpene, 13-epi-sclareol in breast and uterine cancers in vitro.
PubMed: Antibacterial and cytotoxic activity of the acetone extract of the flowers of Salvia sclarea and some natural products.
PubMed: Diels-Alder cycloaddition approach to puupehenone-related metabolites: synthesis of the potent angiogenesis inhibitor 8-epipuupehedione.
PubMed: Liposomes modify the subcellular distribution of sclareol uptake by HCT-116 cancer cell lines.
PubMed: Sclareol induces apoptosis in human HCT116 colon cancer cells in vitro and suppression of HCT116 tumor growth in immunodeficient mice.
PubMed: Structure elucidation and antibacterial activity of new fungal metabolites of sclareol.
PubMed: Calorimetric study on the induction of interdigitated phase in hydrated DPPC bilayers by bioactive labdanes and correlation to their liposome stability: The role of chemical structure.
PubMed: Hemisynthesis of new labdane derivatives from (-)-sclareol.
PubMed: Synthesis of ent-thallusin.
PubMed: A new route toward 7-Oxo-13-hydroxy-8,11,13-podocarpatrienes from labdane diterpenes.
PubMed: Labd-14-ene-8,13-diol (sclareol) induces cell cycle arrest and apoptosis in human breast cancer cells and enhances the activity of anticancer drugs.
PubMed: Cytotoxic and antitumor activity of liposome-incorporated sclareol against cancer cell lines and human colon cancer xenografts.
PubMed: NpPDR1, a pleiotropic drug resistance-type ATP-binding cassette transporter from Nicotiana plumbaginifolia, plays a major role in plant pathogen defense.
PubMed: First enantiospecific synthesis of the antitumor marine sponge metabolite (-)-15-oxopuupehenol from (-)-sclareol.
PubMed: A comparative study of the effects of cholesterol and sclareol, a bioactive labdane type diterpene, on phospholipid bilayers.
PubMed: Effect of 13-epi-sclareol on the bacterial respiratory chain.
PubMed: Pathogen-responsive expression of a putative ATP-binding cassette transporter gene conferring resistance to the diterpenoid sclareol is regulated by multiple defense signaling pathways in Arabidopsis.
PubMed: Identification of regulatory sequence elements within the transcription promoter region of NpABC1, a gene encoding a plant ABC transporter induced by diterpenes.
PubMed: Antibacterial diterpenoids from Astragalus brachystachys.
PubMed: The plant PDR family of ABC transporters.
PubMed: Molecular basis of pimarane compounds as novel activators of large-conductance Ca(2+)-activated K(+) channel alpha-subunit.
PubMed: The ABC transporter SpTUR2 confers resistance to the antifungal diterpene sclareol.
PubMed: Chromatographic (GC-MS, HPLC) and virological evaluations of Salvia sclarea infected by BBWV-I.
PubMed: A plant plasma membrane ATP binding cassette-type transporter is involved in antifungal terpenoid secretion.
PubMed: Labdane type diterpenes down-regulate the expression of c-Myc protein, but not of Bcl-2, in human leukemia T-cells undergoing apoptosis.
PubMed: Biotransformation of two cytotoxic terpenes, alpha-santonin and sclareol by Botrytis cinerea.
PubMed: Potential nitrite scavengers as inhibitors of the formation of N-nitrosamines in solution and tobacco matrix systems.
PubMed: Synthesis of 11,12-epoxydrim-8,12-en-11-ol, 11,12-diacetoxydrimane, and warburganal from (-)-sclareol.
PubMed: Synthesis and antitumoral activities of marine ent-chromazonarol and related compounds.
PubMed: Chemical analysis and antimicrobial activity of the resin Ladano, of its essential oil and of the isolated compounds.
PubMed: The effect of sclareol on growth and cell cycle progression of human leukemic cell lines.
PubMed: A concise synthesis and in vitro cytotoxicity of new labdane diterpenes.
PubMed: A concise conversion of (-)-sclareol into (+)-coronarin E and (-)-7-epi-coronarin A
PubMed: [Plant anatomical and phytochemical evaluation of Salvia species].
PubMed: Biorationals fromNicotiana protect cucumbers againstColletotrichum lagenarium (Pass.) ell. & halst disease development.
PubMed: Terpenoids from Salvia sclarea.
PubMed: Synthesis of manool-related labdane diterpenes as platelet aggregation inhibitors.
PubMed: Identification of four biliary metabolites of the diterpene sclareol in the laboratory rat.
PubMed: Leaf surface chemicals fromNicotiana affecting germination ofPeronospora tabacina (adam) sporangia.
PubMed: Hydroxylation and glucoside conjugation in the microbial metabolism of the diterpene sclareol.
PubMed: Microbial models of mammalian metabolism: fungal metabolism of the diterpene sclareol by Cunninghamella species.
PubMed: Influences of diterpene sclareol glycol on some dopamine related behavior.
PubMed: The effects of the diterpene sclareol glycol on seizures do not depend on central benzodiazepine receptors.
PubMed: The response of diterpene sclareol glycol to acute hypoxia in mice.
PubMed: [The effect of sclareol lactone and sclareol glycol on artificially induced lung metastases of Lewis lung carcinoma (a preliminary report)].
PubMed: Measures of anxiety, retention and stress in the rat following treatment with the diterpene sclareol glycol.
PubMed: Diterpene sclareol glycol inhibits clonidine-induced aggressive responses in mice.
PubMed: Effects of the diterpene sclareol glycol on convulsive seizures.
PubMed: Effects of the diterpene sclareol glycol on body temperature in rats.
PubMed: [Study of the effect of sclareol glycol diterpene on the release of adenohypophysial hormones prolactin, somatotropin and adenocorticotrophic hormone].
PubMed: [Study of the effect of sclareol glycol diterpene on the 3',5'-AMP level].
PubMed: Experimental study of essential oils from two varieties of cultivated thyme, sesquiterpene Germacron and diterpene Sclareol for cholagogic and choleretic activity.
PubMed: [Effect of diterpene sklareol glycol on the conflict test and its correlation with diazepam].
PubMed: [Effects of sklareol-glycol on pentylenetetrazole-induced convulsions and its interaction with diazepam].
PubMed: BIOSYNTHESIS AND METABOLISM OF (14C)SCLAREOL.
PubMed: Biosynthesis of sclareol, beta-sitosterol, and oleanolic acid from mevalonic acid-2-C-14.
PubMed: Biosynthesis of 14C-sclareol and beta-sitosterol from 2-14C-mevalonic acid.
PubMed: [Sclareol, its chemical constitution and use in the synthesis of aromatic principles of amber; a review].
PubMed: [Not Available].
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Soluble in:
 alcohol
 water, 0.08174 mg/L @ 25 °C (est)
Insoluble in:
 water
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