EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

sclareol
(1R,2R,8aS)-1-[(3R)-3-hydroxy-3-methylpent-4-enyl]-2,5,5,8a-tetramethyl-3,4,4a,6,7,8-hexahydro-1H-naphthalen-2-ol

Supplier Sponsors

Fragrance Demo Formulas
Name:(1R,2R,8aS)-1-[(3R)-3-hydroxy-3-methylpent-4-enyl]-2,5,5,8a-tetramethyl-3,4,4a,6,7,8-hexahydro-1H-naphthalen-2-ol
CAS Number: 515-03-7Picture of molecule3D/inchi
Other:17904-64-2
ECHA EINECS - REACH Pre-Reg:208-194-0
FDA UNII:B607NP0Q8Y
Nikkaji Web:J971.072H
Beilstein Number:2054148
MDL:MFCD00869558
CoE Number:10311
XlogP3-AA:4.90 (est)
Molecular Weight:308.50532000
Formula:C20 H36 O2
NMR Predictor:Predict (works with chrome or firefox)
Name:(1R,2R,4aS,8aS)-1-[(3R)-3-hydroxy-3-methylpent-4-enyl]-2,5,5,8a-tetramethyl-3,4,4a,6,7,8-hexahydro-1H-naphthalen-2-ol
CAS Number: 515-03-7 (RRS)Picture of molecule3D/inchi
XlogP3-AA:4.90 (est)
Molecular Weight:308.50532000
Formula:C20 H36 O2
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:flavor and fragrance agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
JECFA Food Flavoring:2029 (-)-sclareol
FLAVIS Number:02.206 (Old)
DG SANTE Food Flavourings:02.206 (-)-sclareol
FEMA Number:4502 (-)-sclareol
FDA:No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm: (-)-SCLAREOL
 
Physical Properties:
Appearance:amber solid (est)
Assay: 98.00 to 100.00 sum of isomers
Food Chemicals Codex Listed: No
Melting Point: 105.00 to 107.00 °C. @ 760.00 mm Hg
Boiling Point: 218.00 to 220.00 °C. @ 19.00 mm Hg
Flash Point: 336.00 °F. TCC ( 169.10 °C. ) (est)
logP (o/w): 5.233 (est)
Soluble in:
 alcohol
 water, 0.08174 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor Type: balsamic
Odor Strength:low
Substantivity:292 hour(s) at 100.00 %
sweet balsamic sage clary sage amber woody weedy
Odor Description:at 100.00 %. sweet balsam clary amber woody weedy
Luebke, William tgsc, (1988)
Odor sample from: RJR Technical Company
Flavor Type: woody
woody balsamic sage clary sage amber weedy brothy cascarilla
Taste Description: sweet woody balsamic clary sage amber weedy brothy cascarilla
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: perfuming agents
 
Suppliers:
Beijing Lys Chemicals
Natural sclareol
Berjé
Sclareol
Happening at Berje
BOC Sciences
For experimental / research use only.
Sclareol >98%
Ernesto Ventós
SCLAREOL NATURAL
ExtraSynthese
For experimental / research use only.
Sclareol
Fleurchem
sclareol natural
Fuzhou Farwell
Sclareol
H. Interdonati, Inc.
Sclareol Natural, Kosher
Featured Products
Indukern F&F
SCLAREOL
Odor: SWEET, BALSAMIC, MUSK, AMBER
M&U International
SCLAREOL, Kosher
Penta International
SCLAREOL NATURAL, Kosher
Penta International
SCLAREOL, Kosher
Reincke & Fichtner
Sclareol natural
Sigma-Aldrich: Aldrich
For experimental / research use only.
Sclareol 98%
Sunaux International
Sclareol
TCI AMERICA
For experimental / research use only.
Sclareol >96.0%(GC)
Ultra International
Sclareol Russian/Ukrainian
Crop Calendar
 
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
None - None found.
S 02 - Keep out of the reach of children.
S 24/25 - Avoid contact with skin and eyes.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 > 5000 mg/kg
Food and Chemical Toxicology. Vol. 30, Pg. 115S, 1992.

Dermal Toxicity:
skin-rabbit LD50 > 5000 mg/kg
Food and Chemical Toxicology. Vol. 30, Pg. 115S, 1992.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: flavor and fragrance agents
IFRA Critical Effect: Sensitization
IFRA Purity Specification: 98% minimum purity
IFRA fragrance material specification:
 Sclareol used as a fragrance ingredient should have a minimum purity of 98%.
IFRA: View Standard
maximum skin levels for fine fragrances:
  0.0200 % and are based on the assumption that the fragrance mixture is used at 20% in a consumer product (IFRA Use Level Survey). (IFRA, 2004)
Recommendation for sclareol usage levels up to:
  4.0000 % in the fragrance concentrate.
use level in formulae for use in cosmetics:
  0.0300 %
Dermal Systemic Exposure in Cosmetic Products:
 0.0008 mg/kg/day (IFRA, 2004)
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 0.67 (μg/capita/day)
Modified Theoretical Added Maximum Daily Intake (mTAMDI): 3900 (μg/person/day)
Threshold of Concern:1800 (μg/person/day)
Structure Class: I
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 24
 average usual ppmaverage maximum ppm
baked goods: 10.0000050.00000
beverages(nonalcoholic): 5.0000025.00000
beverages(alcoholic): 5.0000025.00000
breakfast cereal: 5.0000025.00000
cheese: 7.0000035.00000
chewing gum: --
condiments / relishes: 20.00000100.00000
confectionery froastings: 10.0000050.00000
egg products: --
fats / oils: 5.0000025.00000
fish products: 2.0000010.00000
frozen dairy: 7.0000035.00000
fruit ices: 10.0000050.00000
gelatins / puddings: 10.0000050.00000
granulated sugar: --
gravies: 5.0000025.00000
hard candy: 10.0000050.00000
imitation dairy: 7.0000035.00000
instant coffee / tea: 5.0000025.00000
jams / jellies: 7.0000035.00000
meat products: 2.0000010.00000
milk products: 7.0000035.00000
nut products: 5.0000025.00000
other grains: 5.0000025.00000
poultry: 2.0000010.00000
processed fruits: 7.0000035.00000
processed vegetables: 7.0000035.00000
reconstituted vegetables: 7.0000035.00000
seasonings / flavors: 5.0000025.00000
snack foods: 10.0000050.00000
soft candy: 10.0000050.00000
soups: 5.0000025.00000
sugar substitutes: --
sweet sauces: 5.0000025.00000
 
Food categories according to Commission Regulation EC No. 1565/2000 (EC, 2000) in FGE.06 (EFSA, 2002a). According to the Industry the "normal" use is defined as the average of reported usages and "maximum use" is defined as the 95th percentile of reported usages (EFSA, 2002i).
Note: mg/kg = 0.001/1000 = 0.000001 = 1/1000000 = ppm.
 average usage mg/kgmaximum usage mg/kg
Dairy products, excluding products of category 02.0 (01.0): 7.0000035.00000
Fats and oils, and fat emulsions (type water-in-oil) (02.0): 5.0000025.00000
Edible ices, including sherbet and sorbet (03.0): 10.0000050.00000
Processed fruit (04.1): 7.0000035.00000
Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2): --
Confectionery (05.0): 10.0000050.00000
Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0): 5.0000025.00000
Bakery wares (07.0): 10.0000050.00000
Meat and meat products, including poultry and game (08.0): 2.0000010.00000
Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0): 2.0000010.00000
Eggs and egg products (10.0): --
Sweeteners, including honey (11.0): --
Salts, spices, soups, sauces, salads, protein products, etc. (12.0): 5.0000025.00000
Foodstuffs intended for particular nutritional uses (13.0): 10.0000050.00000
Non-alcoholic ("soft") beverages, excl. dairy products (14.1): 5.0000025.00000
Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2): 10.0000050.00000
Ready-to-eat savouries (15.0): 20.00000100.00000
Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0): 5.0000025.00000
 
Safety References:
European Food Safety Athority(efsa):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Flavouring Group Evaluation 18, Revision 1 (FGE. 18 Rev1)[1] : Aliphatic, alicyclic and aromatic saturated and unsaturated tertiary alcohols, aromatic tertiary alcohols and their esters from chemical groups 6 and 8
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 90 (FGE.90): Consideration of Aliphatic, acyclic and alicyclic terpenoid tertiary alcohols and structurally related substances evaluated by JECFA (68th meeting)FGE.18Rev1 (2009)
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 18, Revision 2 (FGE.18Rev2): Aliphatic, alicyclic and aromatic saturated and unsaturated tertiary alcohols, aromatic tertiary alcohols and their esters from chemical groups 6 and 8.
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 18, Revision 3 (FGE.18Rev3): Aliphatic, alicyclic and aromatic saturated and unsaturated tertiary alcohols, aromatic tertiary alcohols and their esters from chemical groups 6 and 8.
View page or View pdf

EPI System: View
Cancer Citations:Search
EPA Substance Registry Services (TSCA):515-03-7
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :73114
National Institute of Allergy and Infectious Diseases:Data
SCCNFP:opinion
WGK Germany:2
(1R,2R,8aS)-1-[(3R)-3-hydroxy-3-methylpent-4-enyl]-2,5,5,8a-tetramethyl-3,4,4a,6,7,8-hexahydro-1H-naphthalen-2-ol
Chemidplus:0000515037
RTECS:QK0301900 for cas# 515-03-7
(1R,2R,4aS,8aS)-1-[(3R)-3-hydroxy-3-methylpent-4-enyl]-2,5,5,8a-tetramethyl-3,4,4a,6,7,8-hexahydro-1H-naphthalen-2-ol
 
References:
 (1R,2R,8aS)-1-[(3R)-3-hydroxy-3-methylpent-4-enyl]-2,5,5,8a-tetramethyl-3,4,4a,6,7,8-hexahydro-1H-naphthalen-2-ol
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:515-03-7
Pubchem (cid):73114
Pubchem (sid):135029099
 (1R,2R,4aS,8aS)-1-[(3R)-3-hydroxy-3-methylpent-4-enyl]-2,5,5,8a-tetramethyl-3,4,4a,6,7,8-hexahydro-1H-naphthalen-2-ol
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:515-03-7
Pubchem (cid):163263
Pubchem (sid):46237757
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS):View
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C09183
HMDB (The Human Metabolome Database):HMDB36827
FooDB:FDB015776
Export Tariff Code:2906.19.5000
Typical G.C.
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
RSC Learn Chemistry:View
FAO:(-)-Sclareol
 
Potential Blenders and core components note
For Odor
amber
(Z)-
abienol
FL/FR
acetoxymethyl isolongifolene
FR
amber acetate
FR
amber butanol
FR
amber carane
FR
amber cyclohexanol
FR
amber decane
FR
amber furan
FR
amber naphthofuran
FL/FR
amber oxepin
FR
amber specialty
FR
amber spirolene
FR
ambergris naphthol
FR
ambermax 50 (Givaudan)
FR
ambrette seed absolute
FL/FR
ambrinol
FR
ambroxan
FL/FR
formoxymethyl isolongifolene
FR
hydroxymethyl isolongifolene 50% in dpg
FR
labdanum absolute
FL/FR
animal
animal carbolactone
FR
balsamic
amyris wood oil
FL/FR
copaifera reticulata extract
FL/FR
fir carboxylate
FR
mastic gum resin
FR
methyl hydrogenated rosinate
FR
opoponax resin (commiphora erythraea var. glabrescens engler)
FL/FR
opoponax resinoid replacer
FR
oriental specialty
FR
styrax resin (liquidambar styraciflua)
FL/FR
styrax resinoid (liquidambar styraciflua)
FL/FR
camphoreous
beta-homo
cyclocitral
FL/FR
citrus
citronella oil
FL/FR
citronella oil java
FR
grapefruit oil c.p. california
FL/FR
bitter
orange peel oil brazil
FL/FR
valencene
FL/FR
dusty
woody furan
FR
floral
4-tert-
butyl cyclohexane carboxaldehyde
FR
decanal / methyl anthranilate schiff's base
FR
heliotropin
FL/FR
(Z)-3-
hexen-1-yl salicylate
FL/FR
orris pyridine 25% IPM
FR
fruity
balsam specialty
FR
cyclohexyl crotonate
FR
green
iso
butyl benzyl carbinol
FL/FR
hay
tobacco leaf absolute
FL/FR
herbal
amber dioxepine
FR
artemisia vestita wall. leaf oil
FR
(+)-alpha-
campholenic aldehyde
FL/FR
clary acetate
FR
clary octenone
FR
clary propyl acetate
FR
clary sage oil france
FL/FR
clary sage resin america
FR
romanal
FR
minty
spearmint absolute
FL/FR
mossy
moss specialty
FR
treemoss absolute
FR
veramoss (IFF)
FR
musk
(Z)-
civet decenone
FL/FR
cyclohexadecanone
FR
juniper lactone
FL/FR
musk methyl ketone
FR
omega-
pentadecalactone
FL/FR
oily
mcp acetate
FR
powdery
alpha-
methyl ionone
FL/FR
midnight passion fragrance
FR
resinous
mastic absolute
FL/FR
spicy
angelica seed absolute
FL/FR
iso
butyl angelate
FL/FR
terpenic
angelica seed oil
FL/FR
tobacco
honey absolute
FL/FR
veltonal (Bedoukian)
FR
waxy
tetradecanal
FL/FR
woody
acetyl cedrene
FR
amber carbinol
FR
amber decatriene
FR
amber dioxane
FR
amber formate
FR
amber pentadecane
FR
ambrene acetal
FR
beta-
caryophyllene alcohol acetate
FL/FR
cedarwood oil texas
FR
cedarwood oil texas fractions
FR
alpha-
cedrene epoxide
FR
cedrenyl acetate
FR
cedrol methyl ether
FR
cedryl acetate
FL/FR
cedryl formate
FR
cistus twig/leaf oil
FL/FR
dihydro-beta-ionone
FL/FR
dragons blood fragrance
FR
frankincense resinoid replacer
FR
georgywood
FR
hydroxyambran
FR
2-
methoxy-4-vinyl phenol
FL/FR
(4aR,5R,7aS,9R)-
octahydro-2,2,5,8,8,9a-hexamethyl-4h-4a,9-methanoazuleno(5,6-d)-1,3-dioxole
FR
patchouli woody amber fragrance
FR
sandalwood oil
FL/FR
sclareolide
FL/FR
tetramethyl-4-methylene-2-heptanol
FR
timber propanol
FR
tobacarol (IFF)
FR
tobacco nonene
FR
verdoxan
FR
vetiver oil china
FL/FR
vetiver specialty
FR
vetiverol
FL/FR
woody carboxylate
FR
woody cyclohexanone
FR
woody dioxolane
FR
woody epoxide
FR
woody ether
FR
woody nonane (ethoxy)
FR
woody propanol
FR
For Flavor
No flavor group found for these
beta-
caryophyllene alcohol acetate
FL/FR
elecampane root oil
FL
amber
amber
amber naphthofuran
FL/FR
angelica seed oil
FL/FR
iso
butyl benzyl carbinol
FL/FR
labdanum absolute
FL/FR
balsamic
copaifera reticulata extract
FL/FR
opoponax resin (commiphora erythraea var. glabrescens engler)
FL/FR
styrax resin (liquidambar styraciflua)
FL/FR
styrax resinoid (liquidambar styraciflua)
FL/FR
cherry
heliotropin
FL/FR
citrus
citronella oil
FL/FR
grapefruit oil c.p. california
FL/FR
valencene
FL/FR
cooling
beta-homo
cyclocitral
FL/FR
fatty
tetradecanal
FL/FR
fruity
alpha-
methyl ionone
FL/FR
bitter
orange peel oil brazil
FL/FR
grassy
tobacco leaf absolute
FL/FR
green
iso
butyl angelate
FL/FR
(+)-alpha-
campholenic aldehyde
FL/FR
(Z)-3-
hexen-1-yl salicylate
FL/FR
herbal
clary sage oil france
FL/FR
honey
honey absolute
FL/FR
minty
spearmint absolute
FL/FR
musk
(Z)-
civet decenone
FL/FR
juniper lactone
FL/FR
resinous
mastic absolute
FL/FR
smoky
2-
methoxy-4-vinyl phenol
FL/FR
spicy
angelica seed absolute
FL/FR
vanilla
omega-
pentadecalactone
FL/FR
woody
(Z)-
abienol
FL/FR
ambrette seed absolute
FL/FR
ambroxan
FL/FR
amyris wood oil
FL/FR
cedryl acetate
FL/FR
cistus twig/leaf oil
FL/FR
dihydro-beta-ionone
FL/FR
sandalwood oil
FL/FR
sclareolide
FL/FR
vetiver oil china
FL/FR
vetiverol
FL/FR
 
Potential Uses:
FRamber
FRbalsam
FRclary sage oil replacer
FRoriental
FRwoody
 
Occurrence (nature, food, other):note
 clary sage oil france @ 0.10-0.20%
Data GC Search Trop Picture
 clary sage oil greece @ 5.20%
Data GC Search Trop Picture
 clary sage oil spain @ 0.45%
Data GC Search Trop Picture
 nutmeg seed
Search Trop Picture
 sage clary sage
Search Trop Picture
 salvia atropatana bunge oil iran @ 13.30%
Data GC Search Trop Picture
 salvia sclarea oil @ 0.06%
Data GC Search Trop Picture
 thyme oil
Search Trop Picture
 
Synonyms:
alpha-ethenyl decahydro-2-hydroxy-a,2,5,5,8a-pentamethyl(1R-(1alpha(R*),2beta,4abeta,8H
(1theta- (1alpha (theta),2beta, 4abeta,8aalpha))-alpha-ethenyl decahydro-2-hydroxy-alpha,2,5,5,8a-pentamethyl-1-naphthalene propanol
(1r,2r,8as)-1-[(3R)-3-hydroxy-3-methylpent-4-en-1-yl]-2,5,5,8a-tetramethyldecahydronaphthalen-2-ol
(1R,2R,8aS)-1-[(3R)-3-hydroxy-3-methylpent-4-enyl]-2,5,5,8a-tetramethyl-3,4,4a,6,7,8-hexahydro-1H-naphthalen-2-ol
(1R-(1alpha(R*), 2beta,4abeta, 8aalpha))-2-hydroxy-alpha,2,5,5,8a-pentamethyl-alpha-vinyl decahydronaphthalene-1-propan-1-ol
(13R)-labd-14-ene-8,13-diol
 labd-14-ene-8,13-diol, (13R)-
1-naphthalenepropanol, a-ethenyldecahydro-2-hydroxy-a,2,5,5,8a-pentamethyl-, (aR,1R,2R,4aS,8aS)-
(-)-sclareol
 sclareol natural
 

Articles:

PubMed:Characterization of two genes for the biosynthesis of abietane-type diterpenes in rosemary (Rosmarinus officinalis) glandular trichomes.
PubMed:[Engineering Saccharomyces cerevisiae for sclareol production].
PubMed:[Preface for special issue on synthetic biology (2013)].
PubMed:Sclareol reduces CD4+ CD25+ FoxP3+ Treg cells in a breast cancer model in vivo.
PubMed:Hh signaling inhibitors from Vitex negundo; naturally occurring inhibitors of the GLI1-DNA complex.
PubMed:Chemical composition and anticancer activity of essential oils of Mediterranean sage (Salvia officinalis L.) grown in different environmental conditions.
PubMed:Extracellular localization of the diterpene sclareol in clary sage (Salvia sclarea L., Lamiaceae).
PubMed:Bioactive constituents of Salvia chrysophylla Stapf.
PubMed:Toward a biosynthetic route to sclareol and amber odorants.
PubMed:Enzymatic biotransformation of terpenes as bioactive agents.
PubMed:A diterpene synthase from the clary sage Salvia sclarea catalyzes the cyclization of geranylgeranyl diphosphate to (8R)-hydroxy-copalyl diphosphate.
PubMed:Cancer cell spheroids as a model to evaluate chemotherapy protocols.
PubMed:Discovery and functional characterization of two diterpene synthases for sclareol biosynthesis in Salvia sclarea (L.) and their relevance for perfume manufacture.
PubMed:Identification of natural diterpenes that inhibit bacterial wilt disease in tobacco, tomato and Arabidopsis.
PubMed:Sclareol exhibits anti-inflammatory activity in both lipopolysaccharide-stimulated macrophages and the λ-carrageenan-induced paw edema model.
PubMed:Antimicrobial evaluation of diterpenes from Copaifera langsdorffii oleoresin against periodontal anaerobic bacteria.
PubMed:First enantiospecific synthesis of marine sesquiterpene quinol akaol A.
PubMed:Four potato (Solanum tuberosum) ABCG transporters and their expression in response to abiotic factors and Phytophthora infestans infection.
PubMed:Synthesis of the scalarane sesterterpenoid 16-deacetoxy-12-epi-scalarafuranacetate.
PubMed:The labdane diterpene sclareol (labd-14-ene-8, 13-diol) induces apoptosis in human tumor cell lines and suppression of tumor growth in vivo via a p53-independent mechanism of action.
PubMed:Isolation, chemical, and biotransformation routes of labdane-type diterpenes.
PubMed:Chemical composition and antimicrobial activity of the essential oils from Cleome spinosa.
PubMed:Sclareol modulates the Treg intra-tumoral infiltrated cell and inhibits tumor growth in vivo.
PubMed:Mitochondria-targeted liposomes improve the apoptotic and cytotoxic action of sclareol.
PubMed:Hemisynthesis of two marine cheilanthane sesterterpenes from (-)-sclareol: first enantioselective synthesis of petrosaspongiolide R.
PubMed:Fragrance material review on sclareol.
PubMed:Diversity of essential oil glands of clary sage (Salvia sclarea L., Lamiaceae).
PubMed:Microbial hydroxylation of sclareol by Rhizopus stolonifer.
PubMed:Cell growth inhibitory action of an unusual labdane diterpene, 13-epi-sclareol in breast and uterine cancers in vitro.
PubMed:Antibacterial and cytotoxic activity of the acetone extract of the flowers of Salvia sclarea and some natural products.
PubMed:Diels-Alder cycloaddition approach to puupehenone-related metabolites: synthesis of the potent angiogenesis inhibitor 8-epipuupehedione.
PubMed:Liposomes modify the subcellular distribution of sclareol uptake by HCT-116 cancer cell lines.
PubMed:Sclareol induces apoptosis in human HCT116 colon cancer cells in vitro and suppression of HCT116 tumor growth in immunodeficient mice.
PubMed:Structure elucidation and antibacterial activity of new fungal metabolites of sclareol.
PubMed:Calorimetric study on the induction of interdigitated phase in hydrated DPPC bilayers by bioactive labdanes and correlation to their liposome stability: The role of chemical structure.
PubMed:Hemisynthesis of new labdane derivatives from (-)-sclareol.
PubMed:Synthesis of ent-thallusin.
PubMed:A new route toward 7-Oxo-13-hydroxy-8,11,13-podocarpatrienes from labdane diterpenes.
PubMed:Labd-14-ene-8,13-diol (sclareol) induces cell cycle arrest and apoptosis in human breast cancer cells and enhances the activity of anticancer drugs.
PubMed:Cytotoxic and antitumor activity of liposome-incorporated sclareol against cancer cell lines and human colon cancer xenografts.
PubMed:NpPDR1, a pleiotropic drug resistance-type ATP-binding cassette transporter from Nicotiana plumbaginifolia, plays a major role in plant pathogen defense.
PubMed:First enantiospecific synthesis of the antitumor marine sponge metabolite (-)-15-oxopuupehenol from (-)-sclareol.
PubMed:A comparative study of the effects of cholesterol and sclareol, a bioactive labdane type diterpene, on phospholipid bilayers.
PubMed:Effect of 13-epi-sclareol on the bacterial respiratory chain.
PubMed:Pathogen-responsive expression of a putative ATP-binding cassette transporter gene conferring resistance to the diterpenoid sclareol is regulated by multiple defense signaling pathways in Arabidopsis.
PubMed:Identification of regulatory sequence elements within the transcription promoter region of NpABC1, a gene encoding a plant ABC transporter induced by diterpenes.
PubMed:Antibacterial diterpenoids from Astragalus brachystachys.
PubMed:The plant PDR family of ABC transporters.
PubMed:Molecular basis of pimarane compounds as novel activators of large-conductance Ca(2+)-activated K(+) channel alpha-subunit.
PubMed:The ABC transporter SpTUR2 confers resistance to the antifungal diterpene sclareol.
PubMed:Chromatographic (GC-MS, HPLC) and virological evaluations of Salvia sclarea infected by BBWV-I.
PubMed:A plant plasma membrane ATP binding cassette-type transporter is involved in antifungal terpenoid secretion.
PubMed:Labdane type diterpenes down-regulate the expression of c-Myc protein, but not of Bcl-2, in human leukemia T-cells undergoing apoptosis.
PubMed:Biotransformation of two cytotoxic terpenes, alpha-santonin and sclareol by Botrytis cinerea.
PubMed:Potential nitrite scavengers as inhibitors of the formation of N-nitrosamines in solution and tobacco matrix systems.
PubMed:Synthesis of 11,12-epoxydrim-8,12-en-11-ol, 11,12-diacetoxydrimane, and warburganal from (-)-sclareol.
PubMed:Synthesis and antitumoral activities of marine ent-chromazonarol and related compounds.
PubMed:Chemical analysis and antimicrobial activity of the resin Ladano, of its essential oil and of the isolated compounds.
PubMed:The effect of sclareol on growth and cell cycle progression of human leukemic cell lines.
PubMed:A concise synthesis and in vitro cytotoxicity of new labdane diterpenes.
PubMed:A concise conversion of (-)-sclareol into (+)-coronarin E and (-)-7-epi-coronarin A
PubMed:[Plant anatomical and phytochemical evaluation of Salvia species].
PubMed:Biorationals fromNicotiana protect cucumbers againstColletotrichum lagenarium (Pass.) ell. & halst disease development.
PubMed:Terpenoids from Salvia sclarea.
PubMed:Synthesis of manool-related labdane diterpenes as platelet aggregation inhibitors.
PubMed:Identification of four biliary metabolites of the diterpene sclareol in the laboratory rat.
PubMed:Leaf surface chemicals fromNicotiana affecting germination ofPeronospora tabacina (adam) sporangia.
PubMed:Hydroxylation and glucoside conjugation in the microbial metabolism of the diterpene sclareol.
PubMed:Microbial models of mammalian metabolism: fungal metabolism of the diterpene sclareol by Cunninghamella species.
PubMed:Influences of diterpene sclareol glycol on some dopamine related behavior.
PubMed:The effects of the diterpene sclareol glycol on seizures do not depend on central benzodiazepine receptors.
PubMed:The response of diterpene sclareol glycol to acute hypoxia in mice.
PubMed:[The effect of sclareol lactone and sclareol glycol on artificially induced lung metastases of Lewis lung carcinoma (a preliminary report)].
PubMed:Measures of anxiety, retention and stress in the rat following treatment with the diterpene sclareol glycol.
PubMed:Diterpene sclareol glycol inhibits clonidine-induced aggressive responses in mice.
PubMed:Effects of the diterpene sclareol glycol on convulsive seizures.
PubMed:Effects of the diterpene sclareol glycol on body temperature in rats.
PubMed:[Study of the effect of sclareol glycol diterpene on the release of adenohypophysial hormones prolactin, somatotropin and adenocorticotrophic hormone].
PubMed:[Study of the effect of sclareol glycol diterpene on the 3',5'-AMP level].
PubMed:Experimental study of essential oils from two varieties of cultivated thyme, sesquiterpene Germacron and diterpene Sclareol for cholagogic and choleretic activity.
PubMed:[Effect of diterpene sklareol glycol on the conflict test and its correlation with diazepam].
PubMed:[Effects of sklareol-glycol on pentylenetetrazole-induced convulsions and its interaction with diazepam].
PubMed:BIOSYNTHESIS AND METABOLISM OF (14C)SCLAREOL.
PubMed:Biosynthesis of sclareol, beta-sitosterol, and oleanolic acid from mevalonic acid-2-C-14.
PubMed:Biosynthesis of 14C-sclareol and beta-sitosterol from 2-14C-mevalonic acid.
PubMed:[Sclareol, its chemical constitution and use in the synthesis of aromatic principles of amber; a review].
PubMed:[Not Available].
 
Notes:
Constit. of Salvia sclarea (clary sage)
Please share your Comments.
Email Address:
Top of Page Home
Copyright © 1980-2018 The Good Scents Company (tgsc) ™ Disclaimer Privacy Policy