amber naphthofuran
Ambrox replacer.
  • Azelis
    • Azelis UK Life Sciences
      Chemical Distribution
      Azelis is a leading global distributor of speciality chemicals.
      Azelis is a leading global speciality chemicals distributor. We provide a diverse range of products and innovative services to more than 20,000 customers. Our in-depth local knowledge is supported by an international structure and value-added services including high levels of technical support and tailored solutions.
      Email: Graham Bott
      Voice: +32 3 613 01 20
      Fax: +32 3 613 01 21
      United Kingdom+44 (0) 1992 82 55 55
      United Kingdom+44 (0) 1992 82 55 66
  • Firmenich
    • Firmenich Inc.
      We Create
      We create perfumes and flavors for the World's most desirable brands.
      Firmenich is the largest privately-owned company in the perfume and flavor business. Swiss and family owned, we have created many of the world’s favorite perfumes for over 100 years and produced a number of the most well known flavors we enjoy each day.
      US Email: Fred Keifer
      US Voice: +1 609 452 1000
      US Fax: +1 609 452 6077
      909120 Ambrox® DL ≥85%
      This ingredient provides warmth, richness and elegance to all areas of perfumery from sheer florals to modern orientals. Due to its power, best effects can be achieved at lower dosages, however, higher levels are often used to provide performance and substantivity.
      922560 Cetalox® ≥96%
      CETALOX® gives rich, elegant effects to all areas of perfumery from sheer florals to modern orientals. Enhanced richness, warmth and depth can be achieved at lower dosages while, at higher levels, it provides exceptional substantivity and performance.
      922588 Cetalox® Laevo ≥96%
      CETALOX® LAEVO gives rich, elegant effects to all areas of perfumery, from sheer florals to modern orientals. It is highly diffusive and brings a unique ambergris effect from top note to dry down.
  • Indukern F&F
  • Lluch Essence
    • Lluch Essence S.L.
      A family company dedicated to sales and distribution
      Flexibility, availability, price and quality.
      Flexibility, availability, price and quality make LLUCH ESSENCE S.L. one of Europe’s references when it comes to essential oils and aroma chemicals, and it is now well known all around the world.
      Email: Info
      Voice: 34 93 379 38 49
      Fax: 34 93 370 65 04
      CETALOX 96%
  • Penta International
    • Penta International Corporation
      Chemistry innovation
      At Penta, our products and services help businesses do business better.
      For over 30 years, Penta Manufacturing Company has played a growing role in worldwide chemistry innovations and applications. As an industry leader, Penta continues to pioneer chemistry-based solutions for practically every area of commerce. Our products and expertise have helped fuel technical advances in dozens of commercial applications including flavoring, coloring, fragrances and chemical processes.
      US Email: Technical Services
      US Email: Sales
      US Voice: (973) 740-2300
      US Fax: (973) 740-1839
      01-24050 AMBROX DL
      04-87500 DODECAHYDRO-3a,6,6,9a-TETRAMETHYLNAPHTO-(2,1-b)-FURAN, Kosher
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Fragrance Demo Formulas
3a,6,6,9a-tetramethyl-2,4,5,5a,7,8,9,9b-octahydro-1H-benzo[e][1]benzofuran (Click)
CAS Number: 3738-00-9 193980-58-4
ECHA EC Number: 223-118-6
FEMA Number: 3471
CoE Number: 10514
XlogP3-AA: 4.70 (est)
Molecular Weight: 236.39836000
Formula: C16 H28 O
NMR Predictor: Predict
EFSA/JECFA Comments: Mixture of diastereoisomers (EFFA, 2010a).
Category: flavor and fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist: Search
Google Patents: Search
US Patents: Search
EU Patents: Search
IBM Patents: Obtain
Pubchem Patents: Search
Read: Under the conditions of intended use - New developments in the FEMA GRAS program and the safety assessment of flavor ingredients
Read: A GRAS assessment program for flavor ingredients
Read: Sensory testing for flavorings with modifying properties. Food Technology
Read: Criteria for the safety evaluation of flavoring substances
Read: A procedure for the safety evaluation of natural flavor complexes used as ingredients in food: essential oils
Read: FEMA Expert Panel: 30 Years of safety evaluation for the flavor industry
Read: Consumption ratio and food predominance of flavoring materials
EFSA Update of results on the monitoring of furan levels in food: Read Report
EFSA Previous report: Results on the monitoring of furan levels in food: Read Report
EFSA Report of the CONTAM Panel on provisional findings on furan in food: Read Report
JECFA Food Flavoring: 1240  1,5,5,9-tetramethyl-13-oxatricyclo(
Flavis Number: 13.072 (Old)
EU SANCO Food Flavourings: 13.072  1,5,5,9-tetramethyl-13-oxatricyclo(

FEMA Number: 3471  1,5,5,9-tetramethyl-13-oxatricyclo(
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Physical Properties:
Appearance: colorless to pale yellow liquid to solid (est)
Assay: 96.00 to 100.00 % 
Food Chemicals Codex Listed: No
Melting Point: 75.00 to  85.00 °C. @ 760.00 mm Hg
Boiling Point: 102.00 to  106.00 °C. @ 25.00 mm Hg
Acid Value: 1.00 max. KOH/g
Vapor Pressure: 0.009000 mm/Hg @ 25.00 °C. (est)
Flash Point: > 212.00 °F. TCC ( > 100.00 °C. )
logP (o/w): 5.256 (est)
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Organoleptic Properties:
Odor Type: amber
Odor Strength: high ,
recommend smelling in a 10.00 % solution or less
Odor Description:
at 10.00 % in dipropylene glycol. 
dry woody amber ambergris musk sweet
Luebke, William tgsc, (1986)
Odor sample from: Firmenich Inc.
Substantivity: > 400 hour(s) at 10.00 % in dipropylene glycol
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: perfuming agents
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Ernesto Ventós
Ernesto Ventós
Ernesto Ventós
Ambrox® DL
Odor: An elegant amber note with a rich woody character
Use: This ingredient provides warmth, richness and elegance to all areas of perfumery from sheer florals to modern orientals. Due to its power, best effects can be achieved at lower dosages, however, higher levels are often used to provide performance and substantivity.
Cetalox® Laevo
Odor: An extremely powerful and elegant amber note
Use: CETALOX® gives rich, elegant effects to all areas of perfumery from sheer florals to modern orientals. Enhanced richness, warmth and depth can be achieved at lower dosages while, at higher levels, it provides exceptional substantivity and performance.
Indukern F&F
Indukern F&F
Lluch Essence
Lluch Essence
Odor: strong amber-note, dry and woody notes
Penta International
Penta International
The Perfumers Apprentice
Ambrox DL
Odor: dry woody amber ambergris musk sweet
The Perfumers Apprentice
Cetalox (F) (crystals)
Vigon International
Ambrox DL
Vigon International
Ambrox Super
Vigon International
Odor: AMBER.
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Safety Information:
European information :
Most important hazard(s):
Xi - Irritant
R 36/37/38 - Irritating to eyes, respiratory system, and skin.
S 02 - Keep out of the reach of children.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36 - Wear suitable protective clothing.
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: flavor and fragrance agents
Recommendation for amber naphthofuran usage levels up to:
  5.0000 % in the fragrance concentrate.
Maximised Survey-derived Daily Intakes (MSDI-EU): 1.20 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 0.10 (μg/capita/day)
Structure Class: III
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 9
Click here to view publication 9
 average usual ppmaverage maximum ppm
baked goods: -0.01000
beverages(nonalcoholic): -0.01000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: -0.01000
egg products: --
fats / oils: --
fish products: --
frozen dairy: -0.01000
fruit ices: -0.01000
gelatins / puddings: -0.01000
granulated sugar: --
gravies: --
hard candy: --
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --
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Safety References:
European Food Safety Athority(efsa): Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...
European Food Safety Authority (EFSA) reference(s):
Flavouring Group Evaluation 59 (FGE.59): Consideration of aliphatic and aromatic ethers evaluated by JECFA (61st meeting) structurally related to aliphatic, alicyclic and aromatic ethers including anisole derivatives evaluated by EFSA in FGE.23 (2006) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf
Flavouring Group Evaluation 33 (FGE.33)[1] - Six Tetrahydrofuran Derivatives from Chemical Groups 13, 14, 16 and 26 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food
View page or View pdf
Scientific Opinion on Flavouring Group Evaluation 59, Revision 1 (FGE.59Rev1): Consideration of aliphatic and aromatic ethers evaluated by JECFA (61st meeting and 63rd meeting) structurally related to aliphatic, alicyclic and aromatic ethers including anisole derivatives evaluated by EFSA in FGE.23 Rev2 (2010)
View page or View pdf
EPI System: View Calculate predicted properties
ECHA Data Sheet: View
EPA Substance Registry Services (TSCA): 3738-00-9
EPA ACToR: Toxicology Data
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 2
Chemidplus: 0003738009
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Leffingwell: chirality
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 3738-00-9
Pubchem (cid): 107166
Pubchem (sid): 135063926
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
HMDB (The Human Metabolome Database): Search
Export Tariff Code: 2932.19.0000
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
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Potential Blenders and core components note
 acetoxymethyl isolongifoleneFR
 acetyl cedreneFR
 amber acetateFR
 amber butanolFR
 amber carbinolFR
 amber cyclohexanolFR
 amber decaneFR
 amber decatrieneFR
 amber dioxaneFR
 amber dodecaneFR
 amber formateFR
 amber furanFR
 amber spiroleneFR
 ambergris naphtholFR
 ambrene acetalFR
 ambrette seed absoluteFL/FR
 ambrette seed oilFL/FR
 amyl benzoateFL/FR
isoamyl salicylateFL/FR
 amyris wood oilFL/FR
 angelica root oilFL/FR
 angelica seed oilFL/FR
 animal carbolactoneFR
 beeswax absoluteFL/FR
siam benzoin resinoidFL/FR
 bois de rose oil brazilFL/FR
 boronia butenalFR
isobutyl salicylateFL/FR
 cabreuva wood oilFR
(+)-alpha-campholenic aldehydeFL/FR
 caramel furanoneFL
wild carrot seed oilFL/FR
beta-caryophyllene oxideFL/FR
 cassia bark oil chinaFL/FR
atlas cedarwood absoluteFR
atlas cedarwood oilFR
 cedrela wood oilFR
alpha-cedrene epoxideFR
 cedrenyl acetateFR
 cedryl acetateFL/FR
 cedryl methyl etherFR
 cistus twig/leaf absoluteFR
 cistus twig/leaf oilFL/FR
 costus valerolactoneFR
black currant bud absoluteFL/FR
 cyclamen aldehydeFL/FR
 dehydro beta-linaloolFL/FR
 diphenyl oxideFL/FR
 dodecanal (aldehyde C-12 lauric)FL/FR
 ethyl laurateFL/FR
 ethyl maltolFL/FR
isoeugenyl acetateFL/FR
 floral pyranolFR
 formoxymethyl isolongifoleneFR
 frankincense oilFL/FR
 galbanum oilFL/FR
 guaiacwood oilFL/FR
 gurjun balsam oilFR
 heliotropyl acetoneFL/FR
 herbal careneFR
alpha-hexyl cinnamaldehydeFL/FR
 hinoki root oilFR
 hydroxymethyl isolongifolene 50% in dpgFR
 immortelle absoluteFL/FR
 juniper berry concreteFR
 labdanum absolute resinFL/FR
 labdanum absoluteFL/FR
 labdanum ethanoneFR
 labdanum oilFL/FR
 labdanum resinoidFR
isolongifolene epoxideFR
isolongifolene ketoneFR
 melon heptenalFL/FR
2-methoxy-4-vinyl phenolFL/FR
 methyl cedryl ketoneFL/FR
 methyl cyclocitroneFR
 methyl dihydrojasmonateFL/FR
 methyl heptine carbonateFL/FR
2-methyl undecanal (aldehyde C-12 mna)FL/FR
 methyl vetivateFR
 musk amberolFR
 musk dimethyl indaneFL/FR
 musk lactoneFR
 musk methyl ketoneFR
gamma-nonalactone (aldehyde C-18 (so-called))FL/FR
 ocean propanalFL/FR
 opoponax absolute (commiphora erythraea var. glabrescens engle)FL/FR
 opoponax resinoid (commiphora erythraea var. glabrescens engle)FR
bitter orange peel oil brazilFL/FR
bitter orange peel oilFL/FR
bitter orange peel oil italyFL/FR
 patchouli ethanoneFR
 patchouli oilFL/FR
 phenethyl phenyl acetateFL/FR
 raspberry ketoneFL/FR
 sandal pentenolFL/FR
 sandalwood oil west australia (santalum spicata)FR
 spruce needle oil canadaFL/FR
 timber propanolFR
 tobacco noneneFR
 tonka bean absoluteFR
gamma-undecalactone (aldehyde C-14 (so-called))FL/FR
10-undecen-1-al (aldehyde C-11 undecylenic)FL/FR
 violet leaf absoluteFL/FR
 watermelon ketoneFR
 woody acetateFR
 woody cyclohexanoneFR
 woody dioxolaneFR
 woody dodecaneFR
 woody etherFR
 woody nonane (ethoxy)FR
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Potential Uses:
 baby powderFR
 bay rumFR
 blue grass 
 cedar forestFR
 christmas blendsFR
 cigar box 
 cloth clean cloths 
 earth humusFR
 fantasy blends 
 fern fougereFR
 fir balsamFR
 forest pine forestFR
 grass sweetFR
 hay new mown hay foin coupeFR
 juniper berryFR
 leather russianFR
 oakmoss mousse de chene mossFR
 ocean sea 
 ocean sea breezeFR
 rain springFR
 tonka beanFR
 woodruff asperulaFR
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Natural Occurrence in: note
 found in nature
Synonyms   Articles   Notes   Search   Top
 amber naphthofuran
 amborl DL
 ambrox DL
 ambrox super
 cetalox laevo
 dodecahydro-3a,6,6,9a-tetramethyl naphtho(2,1-beta)furan
 dodecahydrotetramethyl naphthofuran
 naphtho(2,1-b)furan, dodecahydro-3a,6,6,9a-tetramethyl-
 naphtho[2,1-b]furan, dodecahydro-3a,6,6,9a-tetramethyl-
 tetramethyl dodecahydro-3a,6,6,9a-naphtho(2,1-b)furan
 tetramethyl perhydronaphthofurane
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Info: Ambrox / Ambroxan
Google Patents: (+)-Ambrox, process for production thereof and use thereof
US Patents: 8,222,200 - Organic compounds
PubMed: Toward a biosynthetic route to sclareol and amber odorants.
PubMed: A diterpene synthase from the clary sage Salvia sclarea catalyzes the cyclization of geranylgeranyl diphosphate to (8R)-hydroxy-copalyl diphosphate.
PubMed: Biotransformation of perfumery terpenoids, (-)-ambrox® by a fungal culture Macrophomina phaseolina and a plant cell suspension culture of Peganum harmala.
PubMed: Discovery and functional characterization of two diterpene synthases for sclareol biosynthesis in Salvia sclarea (L.) and their relevance for perfume manufacture.
PubMed: Communic acids: occurrence, properties and use as chirons for the synthesis of bioactive compounds.
PubMed: Isolation, chemical, and biotransformation routes of labdane-type diterpenes.
PubMed: Antibacterial and cytotoxic activity of the acetone extract of the flowers of Salvia sclarea and some natural products.
PubMed: Chiral decalins: preparation from oleanolic acid and application in the synthesis of (-)-9-epi-ambrox.
PubMed: Biotransformation of (-)-ambrox by cell suspension cultures of Actinidia deliciosa.
PubMed: Chiral proton donor reagents: tin tetrachloride--coordinated optically active binaphthol derivatives.
PubMed: Enantio- and diastereoselective stepwise cyclization of polyprenoids induced by chiral and achiral LBAs. A new entry to (-)-ambrox, (+)-podocarpa-8,11,13-triene diterpenoids, and (-)-tetracyclic polyprenoid of sedimentary origin.
PubMed: Oxidative metabolism of ambrox and sclareolide by Botrytis cinerea.
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Similar Items: note
(-)-dodecahydrotetramethyl naphthofuran
dodecahydrotetramethyl epoxynaphthoxepin
Soluble in:
 water, slightly
 water, 2.436 mg/L @ 25 °C (est)
Insoluble in:
 very stable in most media
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