EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

(Z)-ambrettolide
(Z)-omega-6-hexadecenlactone

Supplier Sponsors

Name:(7Z)-17-oxacycloheptadec-7-en-1-one
CAS Number: 123-69-3Picture of molecule3D/inchi
Other:17598-28-6
ECHA EINECS - REACH Pre-Reg:204-644-5
FDA UNII:095I377U8F
Nikkaji Web:J10.068D
XlogP3-AA:5.50 (est)
Molecular Weight:252.39756000
Formula:C16 H28 O2
NMR Predictor:Predict (works with chrome or firefox)
EFSA/JECFA Comments:
CASrn in Register refers to the Z-isomer. Stereoisomeric composition to be specified.
Category:flavor and fragrance agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
FLAVIS Number:10.059 (Old)
DG SANTE Food Flavourings:10.059 hexadec-7-en-16-olide
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:0.95500 to 0.96100 @ 25.00 °C.
Pounds per Gallon - (est).: 7.947 to 7.996
Refractive Index:1.48200 to 1.48800 @ 20.00 °C.
Boiling Point: 398.00 to 399.00 °C. @ 760.00 mm Hg
Flash Point: 334.00 °F. TCC ( 167.78 °C. )
logP (o/w): 5.516 (est)
Soluble in:
 alcohol
 water, 0.5925 mg/L @ 25 °C (est)
Insoluble in:
 water
Similar Items:note
ambrettolide
isoambrettolide
12-norambrienolide
 
Organoleptic Properties:
Odor Type: musk
Odor Strength:medium
musty animal musk ambrette
Odor Description:at 100.00 %. musty animal musk ambrette
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: perfuming agents
 
Suppliers:
BOC Sciences
For experimental / research use only.
Musk Ambrette
PerfumersWorld
Ambrettolide 10% in DPG
PerfumersWorld
Ambrettolide
Odor: natural-musk ambrette-seed floral-musk sweet
Perfumery Laboratory
AMBRETHTOLID IFF 20% DPG (AMBRETTOLIDE IFF 20% DPG)
Odor: The aroma of an ambrette, natural, floral, sweet
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-mouse LDLo 1600 mg/kg
Archives of Environmental Contamination and Toxicology. Vol. 14, Pg. 111, 1985.

oral-rat LD50 339 mg/kg
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 22, Pg. 1513, 1980.

Dermal Toxicity:
skin-rabbit LD50 > 5000 mg/kg
Archives of Environmental Contamination and Toxicology. Vol. 14, Pg. 111, 1985.

skin-rabbit LD50 > 5000 mg/kg
Food and Cosmetics Toxicology. Vol. 13, Pg. 707, 1975.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: flavor and fragrance agents
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 1.90 (μg/capita/day)
Modified Theoretical Added Maximum Daily Intake (mTAMDI): 3900 (μg/person/day)
Threshold of Concern:1800 (μg/person/day)
Structure Class: I
 
Food categories according to Commission Regulation EC No. 1565/2000 (EC, 2000) in FGE.06 (EFSA, 2002a). According to the Industry the "normal" use is defined as the average of reported usages and "maximum use" is defined as the 95th percentile of reported usages (EFSA, 2002i).
Note: mg/kg = 0.001/1000 = 0.000001 = 1/1000000 = ppm.
 average usage mg/kgmaximum usage mg/kg
Dairy products, excluding products of category 02.0 (01.0): 7.0000035.00000
Fats and oils, and fat emulsions (type water-in-oil) (02.0): 5.0000025.00000
Edible ices, including sherbet and sorbet (03.0): 10.0000050.00000
Processed fruit (04.1): 7.0000035.00000
Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2): --
Confectionery (05.0): 10.0000050.00000
Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0): 5.0000025.00000
Bakery wares (07.0): 10.0000050.00000
Meat and meat products, including poultry and game (08.0): 2.0000010.00000
Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0): 2.0000010.00000
Eggs and egg products (10.0): --
Sweeteners, including honey (11.0): --
Salts, spices, soups, sauces, salads, protein products, etc. (12.0): 5.0000025.00000
Foodstuffs intended for particular nutritional uses (13.0): 10.0000050.00000
Non-alcoholic ("soft") beverages, excl. dairy products (14.1): 5.0000025.00000
Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2): 10.0000050.00000
Ready-to-eat savouries (15.0): 20.00000100.00000
Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0): 5.0000025.00000
 
Safety References:
European Food Safety Athority(efsa):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Scientific Opinion on Flavouring Group Evaluation 10, Revision 2 (FGE.10Rev2): Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 10, Revision 3 (FGE.10Rev3): Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30
View page or View pdf

EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):123-69-3
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :5365703
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
(7Z)-17-oxacycloheptadec-7-en-1-one
Chemidplus:0000123693
 
References:
 (7Z)-17-oxacycloheptadec-7-en-1-one
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:123-69-3
Pubchem (cid):5365703
Pubchem (sid):134974739
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):HMDB31086
FooDB:FDB003091
Typical G.C.
ChemSpider:View
 
Potential Blenders and core components note
For Odor
No odor group found for these
methyl carbitol
CS
acidic
acidic
cyclohexyl acetic acid
FL/FR
alcoholic
propyl alcohol
FL/FR
amber
amber furan
FR
ambergris naphthol
FR
alpha-
ambrinol
FL/FR
ambrinol
FR
angelica root oil
FL/FR
angelica seed oil CO2 extract
FL/FR
cistus ladaniferus absolute resin
FL/FR
cistus ladaniferus resin
FR
labdanum absolute
FL/FR
animal
animal carbolactone
FR
animal specialty
FR
iso
butyl quinoline
FR
iso
butyl quinoline
FR
civet absolute
FL/FR
costus valerolactone
FR
para-
cresyl caprylate
FL/FR
para-
cresyl isobutyrate
FL/FR
para-
cresyl phenyl acetate
FL/FR
indolall
FR
indole
FL/FR
indoletal
FR
para-
methyl tetrahydroquinoline
FL/FR
musk indenofuran
FR
piperidine
FL/FR
procavia capensis excrete absolute
FR
skatole
FL/FR
1-oxa
spiro-4,7-dodecane
FR
balsamic
iso
amyl cinnamate
FL/FR
amyl phenyl acetate
FL/FR
iso
bornyl formate
FL/FR
iso
butyl benzoate
FL/FR
guaiyl butyrate
FR
myrrh absolute
FL/FR
opoponax oil (balsamodendron kafal)
FL/FR
opoponax resinoid (balsamodendron kafal)
FR
propyl cinnamate
FL/FR
chocolate
iso
amyl phenyl acetate
FL/FR
2-
methyl butyraldehyde
FL/FR
2,4,5-
trimethyl thiazole
FL/FR
citrus
methyl heptenone
FL/FR
cocoa
2-iso
butyl-3,5-(and 3,6)-dimethyl pyrazine
FL/FR
coffee
1-
hydroxy-2-butanone
FL/FR
earthy
2-
ethyl fenchol
FL/FR
geosmin
FL/FR
muscogene
FR
1-
octen-3-one
FL/FR
ethereal
propyl valerate
FL/FR
fatty
hexyl pivalate
FR
delta-
juniper lactone
FL/FR
4-
methyl octanoic acid
FL/FR
floral
citronellol
FL/FR
para-
cresyl acetate
FL/FR
cyclamen aldehyde
FL/FR
dimethyl anthranilate
FL/FR
dimethyl octanol
FL/FR
linalool oxide (furanoid)
FL/FR
2-
methyl-4-phenyl butanal
FL/FR
phenethyl butyrate
FL/FR
(E)-2,5,9-
trimethyl-4,9-decadien-1-al
FR
fruity
cyclohexyl acetate
FL/FR
2-
ethyl butyl acetate
FL/FR
hexyl propionate
FL/FR
linalyl hexanoate
FL/FR
tetrahydrofurfuryl butyrate
FL/FR
fungal
hydroxymethyl hexyl ethyl ketone
FL/FR
green
2-sec-
butyl-3-methoxypyrazine
FL/FR
1-
heptanol
FL/FR
hexanal dimethyl acetal
FL/FR
(Z)-4-
hexen-1-ol
FL/FR
styralyl acetate
FL/FR
valerian rhizome oil CO2 extract china
FL/FR
herbal
petitgrain heptane
FR
valerian rhizome oil
FL/FR
honey
phenethyl furoate
FL/FR
leathery
castoreum absolute
FL/FR
marine
marine pyridine
FR
minty
ethyl benzoate
FL/FR
mossy
oakmoss absolute
FL/FR
musk
iso
ambrettolide
FL/FR
(3alpha,5alpha)-
androst-16-en-3-ol
FR
(Z)-
civet decenone
FL/FR
ethylene brassylate
FL/FR
ethylene dodecanoate
FR
exaltone (Firmenich)
FR
juniper lactone
FL/FR
(E)-3-
methyl-5-cyclotetradecen-1-one
FR
delta-
muscenone
FR
dextro,laevo-
muscone
FL/FR
musk ambrette
CS
musk ambrette replacer
FR
musk cyclopentenyl propionate
FR
musk dimethyl indane
FL/FR
musk lactone
FR
musk nonane
FR
(Z)-
musk pentane
FR
musk propanoate
FR
omega-
pentadecalactone
FL/FR
musty
2-
acetyl pyrrole
FL/FR
3-
acetyl-2,5-dimethyl furan
FL/FR
cocoa butenal
FL/FR
3-
ethyl phenol
FL/FR
hazelnut pyrazine
FL/FR
menthofuran
FL/FR
ketoiso
phorone
FL/FR
tetrahydrogeranyl acetone
FL/FR
nutty
4,5-
dimethyl-2-ethyl-3-thiazoline
FL/FR
2-
ethyl pyrazine
FL/FR
filbert pyrazine
FL/FR
2-
methyl thio-3,5 or 6-methyl pyrazine
FL/FR
nutty quinoxaline
FL/FR
2,3,5,6-
tetramethyl pyrazine
FL/FR
2,3,5-
trimethyl pyrazine
FL/FR
vinyl sulfurol
FL/FR
phenolic
2,3-
xylenol
FL/FR
spicy
4-
carvomenthenol
FL/FR
cassia bark oleoresin
FL/FR
ginger oleoresin
FL/FR
(E,E)-
piperine
FL/FR
sulfurous
cassis pentanone
FL/FR
tobacco
para-
cresyl isovalerate
FL/FR
vanilla
ortho-
dimethyl hydroquinone
FL/FR
waxy
octyl 2-methyl butyrate
FL/FR
woody
cedarwood oil china
FR
para-
menth-3-en-1-ol
FL/FR
spikenard oil
FL/FR
For Flavor
No flavor group found for these
acetyl acetaldehyde dimethyl acetal
FL
amyl phenyl acetate
FL/FR
2-iso
butyl-3,5-(and 3,6)-dimethyl pyrazine
FL/FR
cyclohexyl methyl pyrazine
FL
2,5-
diethyl thiazole
FL
2,6-
dimethoxy-4-vinyl phenol
FL
ortho-
dimethyl hydroquinone
FL/FR
furfuryl hexanoate
FL
geosmin
FL/FR
hexanal dimethyl acetal
FL/FR
hexyl propionate
FL/FR
hydroxymethyl hexyl ethyl ketone
FL/FR
linalool oxide (furanoid)
FL/FR
linalyl hexanoate
FL/FR
para-
menth-3-en-1-ol
FL/FR
methyl 2-hydroxy-4-methyl valerate
FL
4-
methyl cyclohexanone
FL
para-
methyl tetrahydroquinoline
FL/FR
tris(
methyl thio) methane
FL
2-
methyl-4-phenyl butanal
FL/FR
2-
pentyl-1-buten-3-one
FL
phenethyl furoate
FL/FR
piperidine
FL/FR
(E,E)-
piperine
FL/FR
propyl valerate
FL/FR
skatole
FL/FR
spikenard oil
FL/FR
alcoholic
alcoholic
propyl alcohol
FL/FR
amber
alpha-
ambrinol
FL/FR
cistus ladaniferus absolute resin
FL/FR
labdanum absolute
FL/FR
animal
civet absolute
FL/FR
para-
cresyl caprylate
FL/FR
indole
FL/FR
aromatic
para-
cresyl acetate
FL/FR
para-
cresyl isobutyrate
FL/FR
balsamic
myrrh absolute
FL/FR
opoponax oil (balsamodendron kafal)
FL/FR
brown
1-
hydroxy-2-butanone
FL/FR
burnt
furfuryl alcohol
FL
citrus
ketoiso
phorone
FL/FR
tetrahydrogeranyl acetone
FL/FR
cooling
4-
carvomenthenol
FL/FR
earthy
2-
ethyl fenchol
FL/FR
1-
octen-3-one
FL/FR
fatty
dimethyl octanol
FL/FR
delta-
juniper lactone
FL/FR
4-
methyl octanoic acid
FL/FR
(E)-2-
octenoic acid
FL
floral
iso
amyl cinnamate
FL/FR
iso
amyl phenyl acetate
FL/FR
citronellol
FL/FR
fruity
iso
butyl benzoate
FL/FR
dimethyl anthranilate
FL/FR
2-
ethyl butyl acetate
FL/FR
2,4-
hexadien-1-ol
FL
phenethyl butyrate
FL/FR
propyl cinnamate
FL/FR
styralyl acetate
FL/FR
tetrahydrofurfuryl butyrate
FL/FR
valerian rhizome oil
FL/FR
valerian rhizome oil CO2 extract china
FL/FR
fusel
2-
methyl butyraldehyde
FL/FR
green
angelica root oil
FL/FR
cassis pentanone
FL/FR
cocoa butenal
FL/FR
cyclamen aldehyde
FL/FR
(Z)-4-
hexen-1-ol
FL/FR
methyl heptenone
FL/FR
oakmoss absolute
FL/FR
herbal
angelica seed oil CO2 extract
FL/FR
5-
hydroxymethyl furfural
FL
leathery
castoreum absolute
FL/FR
medicinal
ethyl benzoate
FL/FR
musk
iso
ambrettolide
FL/FR
(Z)-
civet decenone
FL/FR
ethylene brassylate
FL/FR
juniper lactone
FL/FR
dextro,laevo-
muscone
FL/FR
musk dimethyl indane
FL/FR
musty
2-
ethoxythiazole
FL
hazelnut pyrazine
FL/FR
menthofuran
FL/FR
2,3,5-
trimethyl pyrazine
FL/FR
nutty
2-
acetyl pyrrole
FL/FR
3-
acetyl-2,5-dimethyl furan
FL/FR
4,5-
dimethyl-2-ethyl-3-thiazoline
FL/FR
2-
ethyl pyrazine
FL/FR
filbert pyrazine
FL/FR
2-
methyl thio-3,5 or 6-methyl pyrazine
FL/FR
nutty quinoxaline
FL/FR
peanut oxazole
FL
2,3,5,6-
tetramethyl pyrazine
FL/FR
2,4,5-
trimethyl thiazole
FL/FR
vinyl sulfurol
FL/FR
phenolic
para-
cresyl isovalerate
FL/FR
para-
cresyl phenyl acetate
FL/FR
3-
ethyl phenol
FL/FR
2,3-
xylenol
FL/FR
roasted
ethyl 3-(furfuryl thio) propionate
FL
solvent
cyclohexyl acetate
FL/FR
1-
heptanol
FL/FR
sour
3-
methyl valeric acid
FL
spicy
cassia bark oleoresin
FL/FR
ginger oleoresin
FL/FR
sulfurous
methyl 2-(methyl thio) butyrate
FL
methyl thiomethyl butyrate
FL
sweet
cyclohexyl acetic acid
FL/FR
vanilla
omega-
pentadecalactone
FL/FR
vegetable
2-sec-
butyl-3-methoxypyrazine
FL/FR
waxy
octyl 2-methyl butyrate
FL/FR
woody
iso
bornyl formate
FL/FR
 
Potential Uses:
FRamber
FRambergris
FRambreine
FRambrette oil replacer
FL/FRangelica
FRanimal
FRcastoreum
FL/FRcistus
FRcivet
FRcostus
 fecal
 fur
 hair
FRheather
FRlabdanum
FRleather
FRleather russian leather
FRmastic oil replacer
FRmusk
FRmyrrh
FRopoponax
FRspikenard oil replacer
FL/FRvalerian
FRvetiver
 
Occurrence (nature, food, other):note
 not found in nature
 abelmoschus moschatus seed oil @ 7.80%
Data GC Search Trop Picture
 
Synonyms:
(Z)-ambrettolide
 ambrettolide LG
(7Z)-17-oxacycloheptadec-7-en-1-one
(8Z)-oxacycloheptadec-8-en-2-one
(Z)-oxacycloheptadec-8-en-2-one
 hexadec-7-en-16-olide
(Z)-omega-6-hexadecenlactone
(Z)-16-hydroxy-7-hexadecenoic acid lactone
 
 
Notes:
pure essence from secretion of preputial follicles of moschus moschiferus l.. Once used in fruit flavouring; its use has been discontinued due to its toxic nature
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