EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

sclareolide
(R)-(+)-sclareolide

Sponsors

CAS Number: 564-20-5Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:209-269-0
FDA UNII:37W4O0O6E6
Nikkaji Web:J217.066C
MDL:MFCD00134168
CoE Number:16055
XlogP3-AA:4.30 (est)
Molecular Weight:250.38162000
Formula:C16 H26 O2
NMR Predictor:Predict (works with chrome or firefox)
EFSA/JECFA Comments:
Register name to be changed to (R)-(+)-Sclareolide.
Category:cosmetic, flavor and fragrance agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
JECFA Food Flavoring:1165 sclareolide
FLAVIS Number:16.055 (Old)
DG SANTE Food Flavourings:16.055 (R)-(+)-sclareolide
FEMA Number:3794 sclareolide
FDA:No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm: SCLAREOLIDE
 
Physical Properties:
Appearance:white crystals (est)
Assay: 98.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 124.00 to 127.00 °C. @ 760.00 mm Hg
Boiling Point: 320.00 to 321.00 °C. @ 760.00 mm Hg
Vapor Pressure:0.000299 mm/Hg @ 25.00 °C. (est)
Flash Point: 270.00 °F. TCC ( 132.22 °C. )
logP (o/w): 4.151 (est)
Shelf Life: 24.00 month(s) or longer if stored properly.
Storage:store in cool, dry place in tightly sealed containers, protected from heat and light.
Soluble in:
 alcohol
 diethyl phthalate
 isopropyl myristate
 water, 11.99 mg/L @ 25 °C (est)
Insoluble in:
 water
 
Organoleptic Properties:
Odor Type: woody
Odor Strength:medium ,
recommend smelling in a 10.00 % solution or less
Substantivity:108 hour(s) at 10.00 % in dipropylene glycol
dry paper woody ambergris labdanum
Odor Description:at 10.00 % in isopropyl myristate. dry paper woody ambergris labdanum
Luebke, William tgsc, (2007)
Odor sample from: Sigma-Aldrich
aromatic woody mossy cedar tobacco
Odor Description:at 1.00 %. Intense, aromatic, woody and moss like with a cedar and tobacco nuance
Mosciano, Gerard P&F 26, No. 3, 80, (2001)
Flavor Type: woody
aromatic woody cedar tobacco mushroom earthy oakmoss
Taste Description: at 0.10 - 5.00 ppm. Intense aromatic, woody, cedar like, tobacco with a mushroom and earthy nuance. It has a vague perfumey oak moss note
Mosciano, Gerard P&F 26, No. 3, 80, (2001)
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: masking agents
perfuming agents
skin conditioning
 
Suppliers:
Axxence Aromatic
SCLAREOLIDE Natural
Sustainability
Beijing Lys Chemicals
Sclareolide
BOC Sciences
For experimental / research use only.
Sclareolide >98%
Ernesto Ventós
SCLAREOLIDE
Odor: WOODY,RASPBERRY,TOBACCO,MOSS
ExtraSynthese
For experimental / research use only.
(3aR)-(+)-Sclareolide
Fuzhou Farwell
Sclareolide
H. Interdonati, Inc.
Sclareolide Kosher
Featured Products
M&U International
SCLAREOLIDE, Kosher
O'Laughlin Industries
SCLAREOLIDE
Penta International
SCLAREOLIDE, Kosher
Penta International
SLAREOLIDE, NATURAL, Kosher
Reincke & Fichtner
Sclareolide natural
Santa Cruz Biotechnology
For experimental / research use only.
(3aR)-(+)-Sclareolide 97%
Sigma-Aldrich
(3aR)-(+)-Sclareolide, 97%, FG
Certified Food Grade Products
Sunaux International
Sclareolide
Synerzine
Sclareolide
TCI AMERICA
For experimental / research use only.
(3aR)-(+)-Sclareolide >97.0%(GC)
 
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
None - None found.
S 02 - Keep out of the reach of children.
S 24/25 - Avoid contact with skin and eyes.
S 36 - Wear suitable protective clothing.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: cosmetic, flavor and fragrance agents
Recommendation for sclareolide usage levels up to:
  0.5000 % in the fragrance concentrate.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 1.10 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 6.00 (μg/capita/day)
Structure Class: III
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 16
 average usual ppmaverage maximum ppm
baked goods: 2.000003.00000
beverages(nonalcoholic): 1.000005.00000
beverages(alcoholic): 1.000005.00000
breakfast cereal: 1.000003.00000
cheese: 1.000003.00000
chewing gum: --
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: 1.000002.00000
fish products: 1.000002.00000
frozen dairy: 1.000003.00000
fruit ices: --
gelatins / puddings: 1.000002.00000
granulated sugar: --
gravies: 1.000002.00000
hard candy: 1.000003.00000
imitation dairy: 3.0000010.00000
instant coffee / tea: --
jams / jellies: --
meat products: 1.000004.00000
milk products: 2.000004.00000
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: 1.000002.00000
reconstituted vegetables: 1.000002.00000
seasonings / flavors: 1.000003.00000
snack foods: 2.000004.00000
soft candy: 1.000003.00000
soups: 1.000002.00000
sugar substitutes: 1.000003.00000
sweet sauces: 1.000002.00000
 
Safety References:
European Food Safety Athority(efsa):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Flavouring Group Evaluation 80 (FGE.80) - Consideration of alicyclic, alicyclic-fused and aromatic-fused ring lactones evaluated by JECFA (61st meeting) structurally related to a aromatic lactone evaluated by EFSA in FGE.27 (2008)
View page or View pdf

Flavouring Group Evaluation 80, Revision 1 (FGE.80Rev1): Consideration of alicyclic, alicyclic-fused and aromatic-fused ring lactones evaluated by JECFA (61st meeting) structurally related to a aromatic lactone evaluated by EFSA in FGE.27 (2008)
View page or View pdf

EPI System: View
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):564-20-5
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :61129
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
(3aR,5aS,9aS,9bR)-3a,6,6,9a-tetramethyl-1,4,5,5a,7,8,9,9b-octahydrobenzo[e][1]benzofuran-2-one
Chemidplus:0000564205
 
References:
 (3aR,5aS,9aS,9bR)-3a,6,6,9a-tetramethyl-1,4,5,5a,7,8,9,9b-octahydrobenzo[e][1]benzofuran-2-one
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:564-20-5
Pubchem (cid):61129
Pubchem (sid):135017861
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS):View
CHEMBL:View
HMDB (The Human Metabolome Database):HMDB35293
FooDB:FDB013958
Export Tariff Code:2932.99.9090
Typical G.C.
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
EFSA Update of results on the monitoring of furan levels in food:Read Report
EFSA Previous report: Results on the monitoring of furan levels in food:Read Report
EFSA Report of the CONTAM Panel on provisional findings on furan in food:Read Report
 
Potential Blenders and core components note
For Odor
aldehydic
dodecanal (aldehyde C-12 lauric)
FL/FR
2-
methyl undecanal (aldehyde C-12 mna)
FL/FR
10-
undecenal (aldehyde C-11 undecylenic)
FL/FR
amber
(Z)-
abienol
FL/FR
acetoxymethyl isolongifolene
FR
amber acetate
FR
amber butanol
FR
amber carane
FR
amber cyclohexanol
FR
amber specialty
FR
ambergris tincture
FL/FR
ambermax 50 (Givaudan)
FR
ambrein
FR
ambroxan
FL/FR
ambroxide
FL/FR
angelica root oil
FL/FR
cistus ladaniferus resin
FR
cistus ladaniferus resinoid
FR
formoxymethyl isolongifolene
FR
hydroxymethyl isolongifolene 50% in dpg
FR
labdanum absolute
FL/FR
animal
animal carbolactone
FR
costus valerolactone
FR
para-
cresyl isobutyrate
FL/FR
para-
cresyl phenyl acetate
FL/FR
indole
FL/FR
balsamic
amyris wood oil
FL/FR
siam
benzoin resinoid
FL/FR
fir carboxylate
FR
hexyl benzoate
FL/FR
linalyl cinnamate
FL/FR
mastic gum resin
FR
methyl hydrogenated rosinate
FR
opoponax resin (commiphora erythraea var. glabrescens engler)
FL/FR
sclareol
FL/FR
styrax resin (liquidambar styraciflua)
FL/FR
styrax resinoid (liquidambar styraciflua)
FL/FR
berry
raspberry ketone
FL/FR
caramellic
ethyl maltol
FL/FR
immortelle absolute
FL/FR
maltol
FL/FR
citrus
bitter
orange peel oil brazil
FL/FR
coconut
gamma-
nonalactone (aldehyde C-18 (so-called))
FL/FR
gamma-
octalactone
FL/FR
dusty
woody furan
FR
earthy
1-
nonen-3-ol
FL/FR
3-
octanol
FL/FR
1-
octen-3-ol
FL/FR
1-
octen-3-one
FL/FR
fatty
decanol
FL/FR
floral
acetophenone
FL/FR
iso
amyl salicylate
FL/FR
amyl salicylate
FL/FR
bois de rose oil brazil
FL/FR
iso
butyl salicylate
FL/FR
para-
cresyl acetate
FL/FR
cyclamen aldehyde
FL/FR
dihydrojasmone
FL/FR
dimethyl benzyl carbinyl acetate
FL/FR
floral pyranol
FR
heliotropyl acetone
FL/FR
alpha-
hexyl cinnamaldehyde
FL/FR
hyacinth acetals
FL/FR
lilyall
FR
laevo-
linalool
FL/FR
methyl dihydrojasmonate
FL/FR
beta-iso
methyl ionone
FL/FR
2-
methyl naphthalene
FL/FR
nerolidol
FL/FR
nonanol
FL/FR
ocean propanal
FL/FR
orange leaf absolute
FL/FR
orris pyridine 25% IPM
FR
phenethyl phenyl acetate
FL/FR
fruity
balsam specialty
FR
gamma-
decalactone
FL/FR
gamma-
undecalactone (aldehyde C-14 (so-called))
FL/FR
green
diphenyl methane
FL/FR
diphenyl oxide
FL/FR
galbanum oil
FL/FR
3-
hexenal
FL/FR
leafy acetal
FL/FR
methyl heptine carbonate
FL/FR
(E,Z)-2,6-
nonadien-1-ol
FL/FR
perilla alcohol
FL/FR
2-
phenyl propionaldehyde
FL/FR
violet leaf absolute
FL/FR
hay
beeswax absolute
FL/FR
herbal
(+)-alpha-
campholenic aldehyde
FL/FR
daucus carota fruit oil
FL/FR
(1S,5R)-
myrtenyl acetate
FL/FR
laevo-
perillaldehyde
FL/FR
romanal
FR
melon
melon heptenal
FL/FR
(Z)-6-
nonenal
FL/FR
watermelon ketone
FR
minty
methyl salicylate
FL/FR
mossy
moss specialty
FR
oriental specialty
FR
veramoss (IFF)
FR
musk
musk dimethyl indane
FL/FR
oily
mcp acetate
FR
opoponax
opoponax resinoid replacer
FR
powdery
midnight passion fragrance
FR
spicy
allspice berry absolute
FL/FR
angelica seed absolute
FL/FR
benzyl isoeugenol
FL/FR
cassia bark oil china
FL/FR
black
currant bud absolute
FL/FR
iso
eugenyl acetate
FL/FR
para-
methoxycinnamaldehyde
FL/FR
pepper tree berry oil
FL/FR
terpenic
angelica seed oil
FL/FR
frankincense oil
FL/FR
tonka
tonka bean absolute
FR
vanilla
vanillyl isobutyrate
FL/FR
vanillylidene acetone
FL/FR
waxy
1-
dodecanol
FL/FR
ethyl laurate
FL/FR
woody
acetyl cedrene
FR
amber carbinol
FR
amber dioxane
FR
amber formate
FR
amber pentadecane
FR
cedarwood oil terpenes
FL/FR
cedarwood oil texas fractions
FR
cedarwood oil white
FR
alpha-
cedrene epoxide
FR
cedryl formate
FR
cedryl methyl ether
FR
cistus twig/leaf absolute
FR
cistus twig/leaf oil
FL/FR
dragons blood fragrance
FR
frankincense resinoid replacer
FR
georgywood
FR
guaiacwood extract acetate
FR
guaiacwood oil
FL/FR
gurjun balsam oil
FR
hydroxyambran
FR
kaempferia galanga rhizome oil
FL/FR
2-
methoxy-4-vinyl phenol
FL/FR
methyl 2,6,10-trimethyl cyclododeca-2,5,9-trienyl ketone
FR
methyl cedryl ketone
FL/FR
(4aR,5R,7aS,9R)-
octahydro-2,2,5,8,8,9a-hexamethyl-4h-4a,9-methanoazuleno(5,6-d)-1,3-dioxole
FR
patchouli ethanone
FR
patchouli oil
FL/FR
patchouli woody amber fragrance
FR
santall
FR
spruce needle oil canada
FL/FR
tetramethyl-4-methylene-2-heptanol
FR
tobacarol (IFF)
FR
vetiver specialty
FR
woody acetate
FR
woody dioxolane
FR
woody nonane (ethoxy)
FR
For Flavor
No flavor group found for these
ambergris tincture
FL/FR
ambroxide
FL/FR
cistus twig/leaf oil
FL/FR
beta-iso
methyl ionone
FL/FR
amber
amber
angelica seed oil
FL/FR
labdanum absolute
FL/FR
animal
indole
FL/FR
apple
(E,Z)-2,6-
nonadien-1-ol
FL/FR
aromatic
amyl salicylate
FL/FR
para-
cresyl acetate
FL/FR
para-
cresyl isobutyrate
FL/FR
hyacinth acetals
FL/FR
leafy acetal
FL/FR
laevo-
perillaldehyde
FL/FR
balsamic
siam
benzoin resinoid
FL/FR
opoponax resin (commiphora erythraea var. glabrescens engler)
FL/FR
styrax resin (liquidambar styraciflua)
FL/FR
styrax resinoid (liquidambar styraciflua)
FL/FR
vanillylidene acetone
FL/FR
berry
heliotropyl acetone
FL/FR
raspberry ketone
FL/FR
brown
beeswax absolute
FL/FR
camphoreous
kaempferia galanga rhizome oil
FL/FR
caramellic
caramel furanone
FL
ethyl maltol
FL/FR
maltol
FL/FR
cherry
para-
methoxycinnamaldehyde
FL/FR
citrus
laevo-
linalool
FL/FR
coconut
gamma-
nonalactone (aldehyde C-18 (so-called))
FL/FR
cooling
iso
butyl salicylate
FL/FR
creamy
gamma-
undecalactone (aldehyde C-14 (so-called))
FL/FR
earthy
difurfuryl sulfide
FL
1-
hexen-3-yl acetate
FL
1-
nonen-3-ol
FL/FR
1,8-
octane dithiol
FL
1-
octen-3-one
FL/FR
fatty
10-
undecenal (aldehyde C-11 undecylenic)
FL/FR
floral
bois de rose oil brazil
FL/FR
dihydrojasmone
FL/FR
dimethyl benzyl carbinyl acetate
FL/FR
methyl dihydrojasmonate
FL/FR
ocean propanal
FL/FR
orange leaf absolute
FL/FR
fruity
gamma-
decalactone
FL/FR
linalyl cinnamate
FL/FR
bitter
orange peel oil brazil
FL/FR
green
iso
amyl salicylate
FL/FR
angelica root oil
FL/FR
(+)-alpha-
campholenic aldehyde
FL/FR
cyclamen aldehyde
FL/FR
diphenyl methane
FL/FR
diphenyl oxide
FL/FR
galbanum oil
FL/FR
3-
hexenal
FL/FR
hexyl benzoate
FL/FR
immortelle absolute
FL/FR
melon heptenal
FL/FR
methyl heptine carbonate
FL/FR
nerolidol
FL/FR
(Z)-6-
nonenal
FL/FR
2-
phenyl propionaldehyde
FL/FR
violet leaf absolute
FL/FR
herbal
daucus carota fruit oil
FL/FR
honey
phenethyl phenyl acetate
FL/FR
lactonic
gamma-
octalactone
FL/FR
minty
methyl salicylate
FL/FR
mushroom
1-
octen-3-ol
FL/FR
musk
musk dimethyl indane
FL/FR
musty
3-
octanol
FL/FR
oily
2-
methyl naphthalene
FL/FR
phenolic
para-
cresyl phenyl acetate
FL/FR
powdery
acetophenone
FL/FR
smoky
2-
methoxy-4-vinyl phenol
FL/FR
soapy
dodecanal (aldehyde C-12 lauric)
FL/FR
1-
dodecanol
FL/FR
spicy
allspice berry absolute
FL/FR
angelica seed absolute
FL/FR
benzyl isoeugenol
FL/FR
cassia bark oil china
FL/FR
black
currant bud absolute
FL/FR
iso
eugenyl acetate
FL/FR
pepper tree berry oil
FL/FR
vanilla
vanillyl isobutyrate
FL/FR
waxy
decanol
FL/FR
ethyl laurate
FL/FR
alpha-
hexyl cinnamaldehyde
FL/FR
2-
methyl undecanal (aldehyde C-12 mna)
FL/FR
nonanol
FL/FR
woody
(Z)-
abienol
FL/FR
ambroxan
FL/FR
amyris wood oil
FL/FR
cedarwood oil terpenes
FL/FR
frankincense oil
FL/FR
guaiacwood oil
FL/FR
methyl cedryl ketone
FL/FR
(1S,5R)-
myrtenyl acetate
FL/FR
patchouli oil
FL/FR
perilla alcohol
FL/FR
sclareol
FL/FR
spruce needle oil canada
FL/FR
 
Potential Uses:
FRagate
FRamber
FRambergris
FRambreine
FRambrette oil replacer
FRanimal
FRbaby powder
FRbalsam
FRbay rum
FRbayberry
FRblue grass
FRbouquet
FRcabreuva wood
FRcastoreum
FRcedar forest
FRchristmas
 cigar box
FL/FRcistus
 cloth clean cloths
 cool water
FRcoronilla
FRdeertongue absolute replacer
 dry
FRearth
 fantasy blends
FRfern
FRfir balsam
FRfloral
FL/FRguaiacwood
FRhabuba
FRhay new mown hay
FRheather
FRherbal
FRhollyberry
FRincense
FRjuniper berry
FRlabdanum
FRleather
FRleather russian leather
FRmaja
FRmaple
FRmoss
FRmusk
 ocean sea
FRoriental
FRpatchouli
FRpine forest
FRpowder
FRrain
FRsandalwood
FRsea breeze
FRspice
FRspring rain
FRsweet grass
FLtea
FRtobacco
FRtonka bean
 tweed
FRvanilla
FRwoodruff
FRwoody
 
Occurrence (nature, food, other):note
 cigar
Search PMC Picture
 cistus oil @ 0.2%
Data GC Search Trop Picture
 sage clary sage
Search Trop Picture
 tobacco
Search Trop Picture
 
Synonyms:
(+)-norambreinolide
12-norambrienolide
(3ar- (3aalpha,5abeta, 9aalpha,9bbeta))decahydro-3a,6,6,9a-tetramethyl naphth(2,1-b)furan-2(1H)-one
(3aR,5aS,9aS,9bR)-decahydro-3a,6,6,9a-tetramethyl naphtho(2,1-b)furan-2(1H)-one
 decahydro-3a,6,6,9a-tetramethylnaphtho(2,1-b)furan-2(1H)-one
 decahydro-3a,6,6,9a-tetramethylnaphtho[2,1-b]furan-2(1H)-one
3a,4,5,5aalpha, 6,7,8,9,9a,9balpha-decahydro-3abeta,6,6,9abeta-tetramethyl naphtho(2,1-b)furan-2(1H)-one
3a,4,5,5aa,6,7,8,9,9a,9ba-decahydro-3aβ,6,6,9aβ-tetramethylnaphtho(2,1-b)furan-2(1H)-one
 naphtho 2,1-b furan-2(1H)-one, decahydro-3a,6,6,9a-tetramethyl-,
 naphtho(2,1-b)furan-2(1H)-one, decahydro-3a,6,6,9a-tetramethyl-
 naphtho[2,1-b]furan-2(1H)-one, decahydro-3a,6,6,9a-tetramethyl-
(3aR)-(+)-sclareolide
(R)-(+)-sclareolide
 sclareolide natural
 slareolide natural
(3aR,5aS,9aS,9bR)-3a,6,6,9a-tetramethyl-1,4,5,5a,7,8,9,9b-octahydrobenzo[e][1]benzofuran-2-one
3a,6,6,9a-tetramethyl-1,4,5,5a,7,8,9,9b-octahydronaphtho[8,7-d]furan-2-one
3a,6,6,9a-tetramethyl-decahydro-naphtho[2,1-b]furan-2-one
3a,6,6,9a-tetramethyldecahydronaphtho[2,1-b]furan-2(1H)-one
 

Articles:

PubMed:Synthesis of Labdane Diterpenes Galanal A and B from (+)-Sclareolide.
PubMed:Analysis of gene profiles involved in the enhancement of all-trans retinoic acid-induced HL-60 cell differentiation by sesquiterpene lactones identifies asparagine synthetase as a novel target for differentiation-inducing therapy.
PubMed:Enhanced reactivity in dioxirane C-H oxidations via strain release: a computational and experimental study.
PubMed:Total synthesis of (+)-aureol.
PubMed:Scalable, divergent synthesis of meroterpenoids via "borono-sclareolide".
PubMed:Isolation, chemical, and biotransformation routes of labdane-type diterpenes.
PubMed:Exploiting the facile release of trifluoroacetate for the α-methylenation of the sterically hindered carbonyl groups on (+)-sclareolide and (-)-eburnamonine.
PubMed:Manganese porphyrins catalyze selective C-H bond halogenations.
PubMed:Synthesis and biological evaluation of (+)-labdadienedial, derivatives and precursors from (+)-sclareolide.
PubMed:Enantiospecific, biosynthetically inspired formal total synthesis of (+)-liphagal.
PubMed:Differential enhancement of leukaemia cell differentiation without elevation of intracellular calcium by plant-derived sesquiterpene lactone compounds.
PubMed:Structure revision and synthesis of a novel labdane diterpenoid from Zingiber ottensii.
PubMed:Synthesis of (+)-zerumin B using a regioselective singlet oxygen furan oxidation.
PubMed:(3aS,7S,9aS,9bR)-3a,6,6,9a-Tetra-methyl-2-oxoperhydro-naphtho[2,1-b]furan-7-yl acetate.
PubMed:Antibacterial and cytotoxic activity of the acetone extract of the flowers of Salvia sclarea and some natural products.
PubMed:Novel microbial transformations of sclareolide.
PubMed:Chiral decalins: preparation from oleanolic acid and application in the synthesis of (-)-9-epi-ambrox.
PubMed:Synthesis and stereochemistry of the antitumor diterpenoid (+)-zerumin B.
PubMed:The nicholas approach to natural product hybrids.
PubMed:Synthesis of alpha-onoceradiene-like terpene dimers by intermolecular metathesis processes.
PubMed:Synthesis and biological activity of (+)-hedychilactone A and its analogs from (+)-sclareolide.
PubMed:Diversity oriented synthesis of hispanane-like terpene derivatives from (R)-(+)-sclareolide.
PubMed:Synthesis of pelorol and analogues: activators of the inositol 5-phosphatase SHIP.
PubMed:Photochemical access to tetra- and pentacyclic terpene-like products from R-(+)-sclareolide.
PubMed:Identification of regulatory sequence elements within the transcription promoter region of NpABC1, a gene encoding a plant ABC transporter induced by diterpenes.
PubMed:A study on the synthesis of antiangiogenic (+)-coronarin A and congeners from (+)-sclareolide.
PubMed:Enantiospecific synthesis of the antituberculosis marine sponge metabolite (+)-puupehenone. The arenol oxidative activation route.
PubMed:The ABC transporter SpTUR2 confers resistance to the antifungal diterpene sclareol.
PubMed:An approach to furolabdanes and their photooxidation derivatives from R-(+)-sclareolide.
PubMed:Total synthesis and determination of the absolute configuration of coscinosulfate. A new selective inhibitor of Cdc25 protein phosphatase.
PubMed:A plant plasma membrane ATP binding cassette-type transporter is involved in antifungal terpenoid secretion.
PubMed:Oxidative metabolism of ambrox and sclareolide by Botrytis cinerea.
PubMed:Microbial transformation of sclareolide.
 
Notes:
Used to enhance the flavour of beverages and foodstuffs. Flavouring ingredient. Constit. of labdanum oil and clary sage (Salvia sclarea)
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