EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

2-methyl quinoxaline
quinoxaline, 2-methyl-

Sponsors

Name:2-methylquinoxaline
CAS Number: 7251-61-8Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:230-664-9
FDA UNII:03VU31MV6J
Nikkaji Web:J84.970G
Beilstein Number:0113307
MDL:MFCD00006727
XlogP3:1.60 (est)
Molecular Weight:144.17676000
Formula:C9 H8 N2
NMR Predictor:Predict (works with chrome or firefox)
Category:flavoring agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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NCBI:Search
 
Physical Properties:
Appearance:pale yellow to dark red solid (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:1.11000 to 1.12500 @ 20.00 °C.
Pounds per Gallon - (est).: 9.247 to 9.372
Refractive Index:1.61200 to 1.62400 @ 20.00 °C.
Melting Point: 132.00 °C. @ 760.00 mm Hg
Boiling Point: 245.00 to 247.00 °C. @ 760.00 mm Hg
Vapor Pressure:0.049000 mm/Hg @ 25.00 °C. (est)
Vapor Density:4.9 ( Air = 1 )
Flash Point: 197.00 °F. TCC ( 91.67 °C. )
logP (o/w): 1.610
Soluble in:
 alcohol
 water, 3391 mg/L @ 25 °C (est)
Insoluble in:
 water
 
Organoleptic Properties:
Odor Type: coffee
Odor Strength:high ,
recommend smelling in a 0.10 % solution or less
toasted coffee roasted coffee nutty fruity
Odor Description:at 0.10 % in dipropylene glycol. toasted coffee nutty fruity
Flavor Type: burnt
phenolic burnt coffee roasted coffee nutty
Taste Description: phenolic burnt coffee nutty
Odor and/or flavor descriptions from others (if found).
Treatt
2-Methylquinoxaline NI, Kosher
Odor Description:Toasted, roasted, burnt, nutty notes
Taste Description:burnt, roasted hazelnut-like
Used in coffee and roast nut flavours. Normal use levels in finished consumer product: 0.1-10 ppm. Council of Europe limits: Foods (10 ppm); Beverages (10 ppm).C137
 
Cosmetic Information:
None found
 
Suppliers:
Beijing Lys Chemicals
2-Methyl quinoxaline
Charkit Chemical
METHYLQUINOXALINE, 2- M2450
DeLong Chemicals America
2-Methyl quinoxaline, Kosher
Diffusions Aromatiques
2-METHYLQUINOXALINE
Endeavour Specialty Chemicals
2-Methylquinoxaline 98% F&F
Speciality Chemical Product Groups
Ernesto Ventós
2-METHYLQUINOXALINE
Odor: COFFEE, NUTTY, ROAST, TOASTED
Matrix Scientific
For experimental / research use only.
2-Methylquinoxaline, 98%
Penta International
2-METHYL QUINOXALINE
Robinson Brothers
2-Methylquinoxaline F&F
https://www.robinsonbrothers.uk/chemistry-competences
Sigma-Aldrich
2-Methylquinoxaline, ≥97%
Certified Food Grade Products
Synerzine
2-Methyl Quinoxaline
Taytonn
2-Methylquinoxaline
Odor: Coffee, Nutty, Roast, Toasted
TCI AMERICA
For experimental / research use only.
2-Methylquinoxaline >98.0%(GC)
Treatt
2-Methylquinoxaline (1% in DPG)
Treatt
2-Methylquinoxaline
NI, Kosher
Odor: Toasted, roasted, burnt, nutty notes
Flavor: burnt, roasted hazelnut-like
Used in coffee and roast nut flavours. Normal use levels in finished consumer product: 0.1-10 ppm. Council of Europe limits: Foods (10 ppm); Beverages (10 ppm).C137
 
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
Xi - Irritant
R 36/37/38 - Irritating to eyes, respiratory system, and skin.
S 02 - Keep out of the reach of children.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 37/39 - Wear suitable gloves and eye/face protection.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: flavoring agents
Recommendation for 2-methyl quinoxaline usage levels up to:
 not for fragrance use.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 0.12 (μg/capita/day)
Modified Theoretical Added Maximum Daily Intake (mTAMDI): 270 (μg/person/day)
Threshold of Concern:90 (μg/person/day)
Structure Class: III
 
Food categories according to Commission Regulation EC No. 1565/2000 (EC, 2000) in FGE.06 (EFSA, 2002a). According to the Industry the "normal" use is defined as the average of reported usages and "maximum use" is defined as the 95th percentile of reported usages (EFSA, 2002i).
Note: mg/kg = 0.001/1000 = 0.000001 = 1/1000000 = ppm.
 average usage mg/kgmaximum usage mg/kg
Dairy products, excluding products of category 02.0 (01.0): 0.400002.00000
Fats and oils, and fat emulsions (type water-in-oil) (02.0): 0.100000.50000
Edible ices, including sherbet and sorbet (03.0): 0.400002.00000
Processed fruit (04.1): 0.400002.00000
Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2): --
Confectionery (05.0): 1.000005.00000
Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0): 0.200001.00000
Bakery wares (07.0): 1.000005.00000
Meat and meat products, including poultry and game (08.0): 0.100000.40000
Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0): 0.100000.40000
Eggs and egg products (10.0): --
Sweeteners, including honey (11.0): --
Salts, spices, soups, sauces, salads, protein products, etc. (12.0): 0.100000.50000
Foodstuffs intended for particular nutritional uses (13.0): 0.200001.00000
Non-alcoholic ("soft") beverages, excl. dairy products (14.1): 0.200001.00000
Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2): 1.000005.00000
Ready-to-eat savouries (15.0): 1.000005.00000
Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0): 0.200001.00000
 
Safety References:
European Food Safety Athority(efsa):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the Commission related to Flavouring Group Evaluation 17 (FGE.17): Pyrazine derivatives from chemical group 24 (Commission Regulation (EC) No 1565/2000 of 18 July 2000)
View page or View pdf

Flavouring Group Evaluation 50 (FGE.50): Consideration of pyrazine derivatives evaluated by JECFA (57th meeting) structurally related to pyrazine derivatives evaluated by EFSA in FGE.17 (2005) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf

Flavouring Group Evaluation 17, Revision 1 (FGE.17Rev1): Pyrazine derivatives from chemical group 24 - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) [1]
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 17, Revision 2 (FGE.17Rev2): Pyrazine derivatives from chemical group 24
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 50, Revision 1 (FGE.50Rev1): Consideration of pyrazine derivatives evaluated by JECFA (57th meeting) structurally related to pyrazine derivatives evaluated by EFSA in FGE.17Rev2 (2010)
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 17, Revision 3 (FGE.17Rev3): Pyrazine derivatives from chemical group 24
View page or View pdf

EPI System: View
Chemical Carcinogenesis Research Information System:Search
Cancer Citations:Search
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Env. Mutagen Info. Center:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :23686
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
2-methylquinoxaline
Chemidplus:0007251618
RTECS:VD3450000 for cas# 7251-61-8
 
References:
 2-methylquinoxaline
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):23686
Pubchem (sid):134987544
Flavornet:7251-61-8
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
HMDB (The Human Metabolome Database):Search
FooDB:FDB029716
Export Tariff Code:2933.90.8000
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
 
Potential Blenders and core components note
For Odor
No odor group found for these
sulfuryl octanoate
FL/FR
sulfuryl butyrate
FL/FR
sulfuryl decanoate
FL/FR
sulfuryl hexanoate
FL/FR
sulfuryl isobutyrate
FL/FR
sulfuryl propionate
FL/FR
valeraldehyde dibutyl acetal
FL/FR
valeraldehyde propylene glycol acetal
FL/FR
alliaceous
alliaceous
methyl furfuryl disulfide
FL/FR
balsamic
2-
acetyl furan
FL/FR
propyl benzoate
FL/FR
bready
coffee furanone
FL/FR
buttery
acetyl propionyl
FL/FR
3,4-
hexane dione
FL/FR
camphoreous
bornyl isobutyrate
FL/FR
caramellic
caramel furanone solution
FL/FR
coffee dione
FL/FR
cyclotene
FL/FR
ethyl 2-hydroxy-2-methyl butyrate
FL/FR
fenugreek absolute
FL/FR
fenugreek oleoresin
FL/FR
5-
methyl furfural
FL/FR
iso
propenyl pyrazine
FL/FR
chocolate
chocolate pyrazine A
FL/FR
cocoa hexenal
FL/FR
2,6-
dimethyl pyrazine
FL/FR
2,5-
dimethyl pyrazine
FL/FR
2-
methoxypyrazine
FL/FR
2-
methyl butyraldehyde
FL/FR
2,4,5-
trimethyl thiazole
FL/FR
coconut
alpha-
angelica lactone
FL/FR
gamma-
heptalactone
FL/FR
coffee
cichorium intybus root extract
FL/FR
cichorium intybus root solid extract
FL/FR
coffea arabica seed extract
FL/FR
roasted
coffea arabica seed extract
FL/FR
coffea arabica seed oil
FL/FR
coffee absolute
FL/FR
arabica
coffee bean butter
FL/FR
roasted arabica
coffee bean essence
FL/FR
roasted
coffee bean extract
FL/FR
roasted arabica
coffee bean oil
FL/FR
roasted arabica
coffee bean oil CO2 extract
FL/FR
coffee bean oil extract
FL/FR
coffee difuran
FL/FR
coffee resinoid
FL/FR
furfuryl mercaptan
FL/FR
1-
hydroxy-2-butanone
FL/FR
2-
methyl-3-,5 or 6-(furfuryl thio) pyrazine
FL/FR
corn chip
popcorn pyrimidine
FL/FR
coumarinic
coumane
FL/FR
earthy
2-
ethyl-3-methoxypyrazine
FL/FR
nutty pyrazine
FL/FR
ethereal
acetal
FL/FR
fatty
coconut absolute
FL/FR
fermented
valeraldehyde
FL/FR
floral
(-)-alpha-
bisabolol
FL/FR
para-
cresyl laurate
FL/FR
ortho-
methyl acetophenone
FL/FR
fruity
allyl 2-ethyl butyrate
FL/FR
iso
amyl nonanoate
FL/FR
benzaldehyde
FL/FR
guaiacyl propionate
FL/FR
methyl valerate
FL/FR
3-
methyl-2-butenal
FL/FR
tropical thiazole
FL/FR
green
2-
heptyl furan
FL/FR
(E,Z)-2,6-
nonadien-1-yl acetate
FL/FR
tiglaldehyde
FL/FR
herbal
thymyl methyl ether
FL/FR
wormwood oil america
FL/FR
wormwood oil italy
FL/FR
wormwood oil poland
FL/FR
medicinal
2,6-
xylenol
FL/FR
moldy
strawberry furanone methyl ether
FL/FR
musty
2-
acetyl pyrrole
FL/FR
3-
acetyl-2,5-dimethyl furan
FL/FR
hazelnut pyrazine
FL/FR
menthofuran
FL/FR
naphthyl
para-
methyl anisole
FL/FR
ortho-
methyl anisole
FL/FR
nutty
3-
acetyl pyridine
FL/FR
2-
acetyl-3-ethyl pyrazine
FL/FR
2-
acetyl-3-methyl pyrazine
FL/FR
2-
acetyl-3,5-dimethyl pyrazine
FL/FR
2-
acetyl-5-methyl furan
FL/FR
3,5-
cocoa pyrazine
FL/FR
3,6-
cocoa pyrazine
FL/FR
2,3-
dimethyl pyrazine
FL/FR
4,5-
dimethyl-2-ethyl-3-thiazoline
FL/FR
2-
ethyl pyrazine
FL/FR
2-
ethyl-4-methyl thiazole
FL/FR
filbert heptenone
FL/FR
filbert heptenone B
FL/FR
filbert pyrazine
FL/FR
(+)-(E,S)-
filbertone
FL/FR
(-)-(E,R)-
filbertone
FL/FR
european
hazelnut absolute
FL/FR
roasted
hazelnut infusions
FL/FR
european
hazelnut oil CO2 extract
FL/FR
2,6-
lutidine
FL/FR
2-
methyl pyrazine
FL/FR
5-
methyl quinoxaline
FL/FR
2-
methyl thio-3,5 or 6-methyl pyrazine
FL/FR
2-
methyl-3-(methyl thio) pyrazine
FL/FR
2-
methyl-3-ethoxypyrazine
FL/FR
2-
methyl-3-propyl pyrazine
FL/FR
nutty cyclohexenone
FL/FR
nutty quinoxaline
FL/FR
sesame absolute
FL/FR
sesame absolute CO2 extract
FL/FR
shoyu pyrazine
FL/FR
2,3,5,6-
tetramethyl pyrazine
FL/FR
2,4,5-
trimethyl oxazole
FL/FR
2,3,5-
trimethyl pyrazine
FL/FR
vinyl sulfurol
FL/FR
phenolic
para-alpha-
dimethyl styrene
FL/FR
popcorn
2-
acetyl pyrazine
FL/FR
2-
acetyl thiazole
FL/FR
roasted
fenugreek resinoid
FL/FR
trigonella foenum-graecum seed oil CO2 extract
FL/FR
sulfurous
benzothiazole
FL/FR
furfuryl thioacetate
FL/FR
S-
furfuryl thioformate
FL/FR
2-
methyl 5-(methyl thio) furan
FL/FR
O-
methyl S-1-methoxyhexan-3-yl carbonothioate
FL/FR
3-
thiohexanol
FL/FR
sweet
2-
hydroxy-3,4,5-trimethyl-2-cyclopenten-1-one
FL/FR
tonka
whiskey lactone
FL/FR
vegetable
1-
furfuryl pyrrole
FL/FR
tetrahydrofurfuryl alcohol
FL/FR
woody
juniper berry oleoresin
FL/FR
sandalwood oil
FL/FR
For Flavor
No flavor group found for these
acetyl acetaldehyde dimethyl acetal
FL
2-
acetyl-2-pyrroline
FL
2-
acetyl-6-methyl pyrazine
FL
(E)-
aconitic acid
FL
(-)-alpha-
bisabolol
FL/FR
bornyl isobutyrate
FL/FR
butyramide
FL
chocolate pyrazine A
FL/FR
chocolate pyrazine B
FL
cocos nucifera water
FL
coumane
FL/FR
cyclohexyl methyl pyrazine
FL
2,5-
diethyl thiazole
FL
2,5-
diethyl-4-methyl thiazole
FL
6,7-
dihydro-2,3-dimethyl-5H-cyclopentapyrazine
FL
dimethyl dihydrocyclopentapyrazine
FL
2,5-
dimethyl thiazole
FL
2,5-
dimethyl-3-thiofuroyl furan
FL
ethyl 2-hydroxy-2-methyl butyrate
FL/FR
2-
ethyl-3-methoxypyrazine
FL/FR
(Z+E)-5-
ethyl-4-methyl-2-(2-butyl) thiazoline
FL
(Z+E)-5-
ethyl-4-methyl-2-(2-methyl propyl) thiazoline
FL
2-
formyl pyrrole
FL
3-(2-
furyl) acrolein
FL
guaiacyl propionate
FL/FR
(E,E)-2,4-
heptadien-1-ol
FL
2-
hexyl-5 or 6-keto-1,4-dioxane
FL
2-
hydroxy-3,4,5-trimethyl-2-cyclopenten-1-one
FL/FR
3-
mercapto-3-methyl butyl formate
FL
2-
methoxypyrazine
FL/FR
methyl 2-(methyl thio) acetate
FL
2-
methyl-3-,5 or 6-(furfuryl thio) pyrazine
FL/FR
2-
methyl-3-(methyl thio) pyrazine
FL/FR
2-
methyl-3-ethoxypyrazine
FL/FR
peanut dithiazine
FL
2-
propyl pyridine
FL
pyrazines mixture
FL
pyrrole
FL
para-
salicylic acid
FL
sulfuryl butyrate
FL/FR
sulfuryl decanoate
FL/FR
sulfuryl hexanoate
FL/FR
sulfuryl isobutyrate
FL/FR
thiazole
FL
valeraldehyde propylene glycol acetal
FL/FR
5-
acetyl-2,3-dihydro-1,4-thiazine
FL
sulfuryl formate
FL
sulfuryl octanoate
FL/FR
sulfuryl propionate
FL/FR
valeraldehyde dibutyl acetal
FL/FR
absinthe
absinthe
absinthe flavor
FL
alliaceous
benzyl mercaptan
FL
dicyclohexyl disulfide
FL
2-
methyl thioacetaldehyde
FL
tropical thiazole
FL/FR
anisic
ortho-
methyl acetophenone
FL/FR
astringent
2-
methyl pyridine
FL
bready
2-
propionyl thiazole
FL
brown
fenugreek oleoresin
FL/FR
1-
hydroxy-2-butanone
FL/FR
5-
methyl furfural
FL/FR
burnt
bacon dithiazine
FL
furfuryl alcohol
FL
1-(2-
furfuryl thio) propanone
FL
iso
propenyl pyrazine
FL/FR
2,4,5-
trimethyl oxazole
FL/FR
2,6-
xylenol
FL/FR
buttery
butyroin
FL
3,4-
hexane dione
FL/FR
camphoreous
ortho-
methyl anisole
FL/FR
caramellic
caramel furanone
FL
caramel furanone solution
FL/FR
cyclotene
FL/FR
fenugreek absolute
FL/FR
fenugreek resinoid
FL/FR
chocolate
mocha cream flavor
FL
cocoa
chocolate enhancers
FL
cocoa hexenal
FL/FR
coffee
cappuccino flavor
FL
chicory flavor
FL
chicory root distillates
FL
chicory root essence
FL
roasted
chicory root oil
FL
chicory tincture
FL
cichorium intybus root extract
FL/FR
cichorium intybus root solid extract
FL/FR
roasted
coffea arabica seed extract
FL/FR
coffea arabica seed extract
FL/FR
coffea arabica seed oil
FL/FR
coffea canephora seed extract
FL
coffee absolute
FL/FR
arabica
coffee bean butter
FL/FR
roasted
coffee bean concentrate
FL
roasted arabica
coffee bean essence
FL/FR
roasted
coffee bean essence
FL
roasted robusta
coffee bean essence
FL
roasted
coffee bean extract
FL/FR
roasted robusta
coffee bean extract
FL
dried roasted
coffee bean extract
FL
roasted arabica
coffee bean oil CO2 extract
FL/FR
coffee bean oil extract
FL/FR
coffee creme brulee flavor
FL
coffee difuran
FL/FR
coffee dione
FL/FR
coffee distillates
FL
espresso
coffee distillates
FL
coffee enhancers
FL
espresso
coffee essence
FL
espresso
coffee extract
FL
irish
coffee flavor
FL
coffee flavor
FL
espresso
coffee flavor
FL
dark roast
coffee flavor
FL
coffee liqueur flavor
FL
coffee pyrazine
FL
coffee resinoid
FL/FR
coffee royale flavor
FL
difurfuryl ether
FL
diisoamyl thiomalate
FL
2,4-
dimethyl thiazole
FL
2-
ethyl-4-methyl thiazole
FL/FR
furfuryl mercaptan
FL/FR
methyl furfuryl disulfide
FL/FR
methyl furfuryl mercaptopropionate
FL
methyl furfuryl thiol
FL
2-
methyl-5-vinyl pyrazine
FL
2-iso
propyl pyrazine
FL
2-
thiophene thiol
FL
corn chip
2-
acetyl thiazole
FL/FR
2-
acetyl-2-thiazoline
FL
popcorn pyrimidine
FL/FR
creamy
alpha-
angelica lactone
FL/FR
dairy
creme brulle coffee flavor
FL
earthy
difurfuryl sulfide
FL
(±)-2-
mercapto-5-methylheptan-4-one
FL
2-
methyl-3-propyl pyrazine
FL/FR
ethereal
allyl 2-ethyl butyrate
FL/FR
fatty
coconut absolute
FL/FR
(E,E)-2,4-
decadienal
FL
2-
heptyl furan
FL/FR
(E,E)-2,4-
nonadienal
FL
fishy
4,5-
dimethyl thiazole
FL
fruity
benzaldehyde
FL/FR
furfuryl isobutyrate
FL
furfuryl isovalerate
FL
furfuryl propionate
FL
2,4-
hexadien-1-ol
FL
methyl valerate
FL/FR
3-
methyl-2-butenal
FL/FR
propyl benzoate
FL/FR
tiglaldehyde
FL/FR
fusel
2-
methyl butyraldehyde
FL/FR
garlic
garlic oleoresin
FL
green
dihydroxyacetophenone (mixed isomers)
FL
3,4-
dimethoxystyrene
FL
2,5-
dimethyl thiophene
FL
2,5-
dimethyl-4-ethyl oxazole
FL
3-
methyl pyridine
FL
4-
methyl thiazole
FL
1-(5-
methyl-2-furyl) propan-1-one
FL
2-
methyl-5-isopropyl pyrazine
FL
(E,Z)-2,6-
nonadien-1-yl acetate
FL/FR
2-
vinyl pyrazine
FL
herbal
wormwood oil america
FL/FR
wormwood oil italy
FL/FR
wormwood oil poland
FL/FR
lactonic
gamma-
heptalactone
FL/FR
meaty
benzothiazole
FL/FR
3-
mercapto-2-butanone
FL
2-
methyl 3-(methyl thio) furan
FL
molasses
molasses blackstrap
FL
moldy
strawberry furanone methyl ether
FL/FR
mustard
furfuryl methyl ether
FL
musty
2,5-
dimethyl pyrazine
FL/FR
2-
ethoxythiazole
FL
hazelnut pyrazine
FL/FR
menthofuran
FL/FR
2-
methyl 5-(methyl thio) furan
FL/FR
propionaldehyde
FL
shoyu pyrazine
FL/FR
thymyl methyl ether
FL/FR
2,3,5-
trimethyl pyrazine
FL/FR
naphthyl
para-
methyl anisole
FL/FR
nutty
acetal
FL/FR
2-
acetyl furan
FL/FR
3-
acetyl pyridine
FL/FR
2-
acetyl pyrrole
FL/FR
3-
acetyl-2,5-dimethyl furan
FL/FR
3-
acetyl-2,5-dimethyl thiophene
FL
2-
acetyl-3-ethyl pyrazine
FL/FR
2-
acetyl-3-methyl pyrazine
FL/FR
2-
acetyl-3,5-dimethyl pyrazine
FL/FR
2-
acetyl-5-methyl furan
FL/FR
aconitic acid
FL
almond hazelnut flavor
FL
arachis hypogaea fruit extract
FL
2-
butyl-2-butenal
FL
roasted
chestnut flavor
FL
3,5-
cocoa pyrazine
FL/FR
3,6-
cocoa pyrazine
FL/FR
3,5(6)-
cocoa pyrazine
FL
coffee furanone
FL/FR
2,5-
diethyl pyrazine
FL
3,5-
diethyl-2-methyl pyrazine
FL
2,5-
diethyl-3-methyl pyrazine
FL
2,6-
dimethyl pyrazine
FL/FR
2,3-
dimethyl pyrazine
FL/FR
4,5-
dimethyl-2-ethyl-3-thiazoline
FL/FR
2,4-
dimethyl-5-vinyl thiazole
FL
2-
ethyl pyrazine
FL/FR
1-
ethyl-2-acetyl pyrrole
FL
2-
ethyl-6-methyl pyrazine
FL
filbert heptenone
FL/FR
filbert heptenone B
FL/FR
filbert pyrazine
FL/FR
(+)-(E,S)-
filbertone
FL/FR
(-)-(E,R)-
filbertone
FL/FR
european
hazelnut absolute
FL/FR
european
hazelnut distillates
FL
hazelnut flavor
FL
roasted
hazelnut infusions
FL/FR
european
hazelnut oil CO2 extract
FL/FR
european
hazelnut oleoresin
FL
hazelnut paste
FL
2,6-
lutidine
FL/FR
2-
methyl pyrazine
FL/FR
5-
methyl quinoxaline
FL/FR
2-
methyl thio-3,5 or 6-methyl pyrazine
FL/FR
nutty cyclohexenone
FL/FR
nutty pyrazine
FL/FR
nutty quinoxaline
FL/FR
nutty thiazole
FL
peanut oxazole
FL
sesame absolute
FL/FR
sesame absolute CO2 extract
FL/FR
sesame distillates
FL
tetrahydrofurfuryl alcohol
FL/FR
2,3,5,6-
tetramethyl pyrazine
FL/FR
2,4,5-
trimethyl thiazole
FL/FR
vinyl sulfurol
FL/FR
onion
furfuryl isopropyl sulfide
FL
popcorn
2-
propionyl-2-thiazoline
FL
roasted
2-
acetyl pyrazine
FL/FR
roasted arabica
coffee bean oil
FL/FR
ethyl 3-(furfuryl thio) propionate
FL
furfuryl thioacetate
FL/FR
hexyl mercaptan
FL
O-
methyl S-1-methoxyhexan-3-yl carbonothioate
FL/FR
trigonella foenum-graecum seed oil CO2 extract
FL/FR
solvent
2-
ethyl furan
FL
methyl phenyl sulfide
FL
spicy
chocolate cinnamon hazelnut flavor
FL
cinnamon hazelnut cappuccino flavor
FL
cinnamon hazelnut cream flavor
FL
para-alpha-
dimethyl styrene
FL/FR
sulfurous
2,3-
butane dithiol
FL
butyl mercaptan
FL
ethyl methyl sulfide
FL
O-
ethyl S-1-methoxyhexan-3-yl carbonothioate
FL
S-
ethyl thioacetate
FL
S-
furfuryl thioformate
FL/FR
furfuryl thiopropionate
FL
3-
methyl-2-butane thiol
FL
2-
thienyl mercaptan
FL
3-
thiohexanol
FL/FR
toasted
acetyl propionyl
FL/FR
vanilla
vanilla hazelnut flavor
FL
vegetable
1-
furfuryl pyrrole
FL/FR
waxy
para-
cresyl laurate
FL/FR
winey
iso
amyl nonanoate
FL/FR
5-
ethyl-2-methyl pyridine
FL
valeraldehyde
FL/FR
woody
juniper berry oleoresin
FL/FR
sandalwood oil
FL/FR
whiskey lactone
FL/FR
 
Potential Uses:
 chocolate cocoa
FLcoffee
FLnut roasted nut
FRpassion fruit
FLpork
 
Occurrence (nature, food, other):note
 almond roasted almond
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 cocoa
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 coffee
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 passion fruit
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 pork
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Synonyms:
 coffee oxaline
2-methyl chinoxaline
2-methylquinoxaline
 quinoxaline, 2-methyl-
 

Articles:

US Patents:3,931,166 - Certain 2,5-dimethyl-3-thiopyrazines
PubMed:Antimicrobial activity of quinoxaline 1,4-dioxide with 2- and 3-substituted derivatives.
PubMed:Pyrrolo[1,2-a]quinoxalines: novel synthesis via annulation of 2-alkylquinoxalines.
PubMed:Investigation of the antidyskinetic site of action of metabotropic and ionotropic glutamate receptor antagonists. Intracerebral infusions in 6-hydroxydopamine-lesioned rats with levodopa-induced dyskinesia.
PubMed:mGluR1, but not mGluR5, activates feed-forward inhibition in the medial prefrontal cortex to impair decision making.
PubMed:Microinjections of urocortin1 into the nucleus ambiguus of the rat elicit bradycardia.
PubMed:2-Methyl-3-(n-octylsulfan-yl)quinoxaline.
PubMed:2-(3-Aryl-2-propenoyl)-3-methylquinoxaline-1,4-dioxides: a novel cluster of tumor-specific cytotoxins which reverse multidrug resistance.
PubMed:Cardiovascular responses to microinjections of urocortins into the NTS: role of inotropic glutamate receptors.
PubMed:Face-washing behavior induced by the group I metabotropic glutamate receptor agonist (S)-3,5-DHPG in mice is mediated by mGlu1 receptor.
PubMed:Involvement of AMPA/kainate, NMDA, and mGlu5 receptors in the nucleus accumbens core in cue-induced reinstatement of cocaine seeking in rats.
PubMed:Detection of dideoxyosone intermediates of glycation using a monoclonal antibody: characterization of major epitope structures.
PubMed:Retrograde endocannabinoid signaling in a postsynaptic neuron/synaptic bouton preparation from basolateral amygdala.
PubMed:On the microscopic theory of polar solvation dynamics.
PubMed:Preparation and quantification of methylglyoxal in human plasma using reverse-phase high-performance liquid chromatography.
PubMed:Thermodynamic properties of quinoxaline-1,4-dioxide derivatives: a combined experimental and computational study.
PubMed:Effects of static vs. tidal hydrology on pollutant transformation in wetland sediments.
PubMed:Alternative pathway for the formation of 4,5-dihydroxy-2,3-pentanedione, the proposed precursor of 4-hydroxy-5-methyl-3(2H)-furanone as well as autoinducer-2, and its detection as natural constituent of tomato fruit.
PubMed:Role of guanylyl cyclase and cytochrome P-450 on renal response to nitric oxide.
PubMed:5-hydroxytryptamine3 (5-HT3) receptors mediate spinal 5-HT antinociception: an antisense approach.
PubMed:The metabotropic glutamate receptor agonist 1S,3R-ACPD stimulates and modulates NMDA receptor mediated excitotoxicity in organotypic hippocampal slice cultures.
PubMed:Synthesis and cytotoxicity of 2-methyl-4, 9-dihydro-1-substituted-1H-imidazo[4,5-g]quinoxaline-4,9-diones and 2,3-disubstituted-5,10-pyrazino[2,3-g]quinoxalinediones.
PubMed:Evidence of high levels of methylglyoxal in cultured Chinese hamster ovary cells.
PubMed:MK-801-induced hyperlocomotion: differential effects of M100907, SDZ PSD 958 and raclopride.
PubMed:5-Hydroxytryptamine-facilitated release of substance P from rat spinal cord slices is mediated by nitric oxide and cyclic GMP.
PubMed:Pharmacological properties of quinoxaline derivatives as a new class of 5-HT3 receptor antagonists.
PubMed:Methylglyoxal assay in cells as 2-methylquinoxaline using 1,2-diaminobenzene as derivatizing reagent.
PubMed:Pharmacology of cloned human 5-HT1D receptor-mediated functional responses in stably transfected rat C6-glial cell lines: further evidence differentiating human 5-HT1D and 5-HT1B receptors.
PubMed:Serotonin enhances gastric acid response to TRH analogue in dorsal vagal complex through 5-HT2 receptors in rats.
PubMed:Differential affinity of dihydroimidazoquinoxalines and diimidazoquinazolines to the alpha 1 beta 2 gamma 2 and alpha 6 beta 2 gamma 2 subtypes of cloned GABAA receptors.
PubMed:Noradrenergic mediation of spinal antinociception by 5-hydroxytryptamine: characterization of receptor subtypes.
PubMed:The assay of methylglyoxal in biological systems by derivatization with 1,2-diamino-4,5-dimethoxybenzene.
PubMed:5-hydroxytryptamine (5-HT)1A receptors and the tail-flick response. I. 8-hydroxy-2-(di-n-propylamino) tetralin HBr-induced spontaneous tail-flicks in the rat as an in vivo model of 5-HT1A receptor-mediated activity.
PubMed:Characterization of serotonin receptors in isolated rat intramyocardial coronary artery.
PubMed:Simple and sensitive determination of methylglyoxal in biological samples by gas chromatography with electron-capture detection.
PubMed:Determination of methylglyoxal as 2-methylquinoxaline by high-performance liquid chromatography and its application to biological samples.
PubMed:Cyclic voltammetry of phenazines and quinoxalines including mono- and di-N-oxides. Relation to structure and antimicrobial activity.
PubMed:[Ergotropic efficacy of 2,3-dimethylquinoxaline-1,4-dioxide and 2-methylquinoxaline-1,4-dioxide in growing broilers using hydrocolloid-rich rations as well as broiler fattening feed].
PubMed:Studies on biologically active pteridines. III. The absolute configuration at the C-6 chiral center of tetrahydrobiopterin cofactor and related compounds.
PubMed:Antibacterial effects of iodinin, 2-methylquinoxaline di-n-oxide and 2,6-dimethoxybenzoquinone in vitro.
 
Notes:
Flavouring compound [Flavornet]
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