2-acetyl-6-methyl pyrazine
1-(6-methylpyrazin-2-yl)ethanone
 
Notes:
None found
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1-(6-methylpyrazin-2-yl)ethanone (Click)
CAS Number: 22047-26-3Picture of molecule
Nikkaji Web: J624.962K
CoE Number: 11298
XlogP3-AA: 0.20 (est)
Molecular Weight: 136.15396000
Formula: C7 H8 N2 O
NMR Predictor: Predict (works with chrome or firefox)
Category: flavoring agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
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Perfumer and Flavorist: Search
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Pubchem Patents: Search
Flavis Number: 14.087 (Old)
DG SANTE Food Flavourings: 14.087  2-acetyl-6-methylpyrazine
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Melting Point: 33.00 °C. @ 760.00 mm Hg
Boiling Point: 225.00 to  227.00 °C. @ 760.00 mm Hg (est)
Boiling Point: 280.00 °C. @ 760.00 mm Hg
Vapor Pressure: 0.069000 mm/Hg @ 25.00 °C. (est)
Flash Point: 204.00 °F. TCC ( 95.40 °C. ) (est)
logP (o/w): 0.447 (est)
Soluble in:
 alcohol
 water, 6.241e+004 mg/L @ 25 °C (est)
Insoluble in:
 water
Similar Items: note
2-acetyl-3-methyl pyrazine
2-acetyl-5-methyl pyrazine
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Organoleptic Properties:
Odor Type: roasted
Odor Strength: high ,
recommend smelling in a 0.01 % solution or less
 roasted  coffee  cocoa  popcorn  coffee roasted coffee  
Odor Description:
at 0.01 % in propylene glycol. 
roasted coffee cocoa popcorn
  
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Cosmetic Information:
None found
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Suppliers:
Chemical Sources Association
Need This Item for Flavor/Food?: You can contact the Chemical Sources Association
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: flavoring agents
Recommendation for 2-acetyl-6-methyl pyrazine usage levels up to:
 not for fragrance use.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 0.028 (μg/capita/day)
Modified Theoretical Added Maximum Daily Intake (mTAMDI): 270 (μg/person/day)
Threshold of Concern:540 (μg/person/day)
Structure Class: II
 
Food categories according to Commission Regulation EC No. 1565/2000 (EC, 2000) in FGE.06 (EFSA, 2002a). According to the Industry the "normal" use is defined as the average of reported usages and "maximum use" is defined as the 95th percentile of reported usages (EFSA, 2002i).
Note: mg/kg = 0.001/1000 = 0.000001 = 1/1000000 = ppm.
 average usage mg/kgmaximum usage mg/kg
Dairy products, excluding products of category 02.0 (01.0): 0.400002.00000
Fats and oils, and fat emulsions (type water-in-oil) (02.0): 0.100000.50000
Edible ices, including sherbet and sorbet (03.0): 0.400002.00000
Processed fruit (04.1): 0.400002.00000
Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2): --
Confectionery (05.0): 1.000005.00000
Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0): 0.200001.00000
Bakery wares (07.0): 1.000005.00000
Meat and meat products, including poultry and game (08.0): 0.100000.40000
Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0): 0.100000.40000
Eggs and egg products (10.0): --
Sweeteners, including honey (11.0): --
Salts, spices, soups, sauces, salads, protein products, etc. (12.0): 0.100000.50000
Foodstuffs intended for particular nutritional uses (13.0): 0.200001.00000
Non-alcoholic ("soft") beverages, excl. dairy products (14.1): 0.200001.00000
Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2): 1.000005.00000
Ready-to-eat savouries (15.0): 1.000005.00000
Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0): 0.200001.00000
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Safety References:
European Food Safety Athority(efsa): Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...
European Food Safety Authority (EFSA) reference(s):
Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the Commission related to Flavouring Group Evaluation 17 (FGE.17): Pyrazine derivatives from chemical group 24 (Commission Regulation (EC) No 1565/2000 of 18 July 2000)
View page or View pdf
Flavouring Group Evaluation 50 (FGE.50): Consideration of pyrazine derivatives evaluated by JECFA (57th meeting) structurally related to pyrazine derivatives evaluated by EFSA in FGE.17 (2005) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf
Flavouring Group Evaluation 17, Revision 1 (FGE.17Rev1): Pyrazine derivatives from chemical group 24 - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) [1]
View page or View pdf
Scientific Opinion on Flavouring Group Evaluation 17, Revision 2 (FGE.17Rev2): Pyrazine derivatives from chemical group 24
View page or View pdf
Scientific Opinion on Flavouring Group Evaluation 50, Revision 1 (FGE.50Rev1): Consideration of pyrazine derivatives evaluated by JECFA (57th meeting) structurally related to pyrazine derivatives evaluated by EFSA in FGE.17Rev2 (2010)
View page or View pdf
Scientific Opinion on Flavouring Group Evaluation 17, Revision 3 (FGE.17Rev3): Pyrazine derivatives from chemical group 24
View page or View pdf
EPI System: View
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 527821
National Institute of Allergy and Infectious Diseases: Data
 1-(6-methylpyrazin-2-yl)ethanone
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References:
 1-(6-methylpyrazin-2-yl)ethanone
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 527821
Pubchem (sid): 125682123
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
HMDB (The Human Metabolome Database): Search
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
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Potential Blenders and core components note
 
For Odor
No odor group found for these
 sulfuryl octanoateFL/FR
 sulfuryl butyrateFL/FR
 sulfuryl decanoateFL/FR
 sulfuryl hexanoateFL/FR
 sulfuryl isobutyrateFL/FR
 sulfuryl propionateFL/FR
 methyl furfuryl disulfideFL/FR
balsamic
2-acetyl furanFL/FR
caramellic
 caramel furanone solutionFL/FR
 coffee dioneFL/FR
 cycloteneFL/FR
 fenugreek oleoresinFL/FR
5-methyl furfuralFL/FR
chocolate
2,6-dimethyl pyrazineFL/FR
2,5-dimethyl pyrazineFL/FR
2-methyl butyraldehydeFL/FR
2,4,5-trimethyl thiazoleFL/FR
coffee
 cichorium intybus root extractFL/FR
 cichorium intybus root solid extractFL/FR
 coffea arabica seed extractFL/FR
roasted coffea arabica seed extractFL/FR
 coffea arabica seed oilFL/FR
 coffee absoluteFL/FR
arabica coffee bean butterFL/FR
roasted arabica coffee bean essenceFL/FR
roasted coffee bean extractFL/FR
roasted arabica coffee bean oilFL/FR
roasted arabica coffee bean oil CO2 extractFL/FR
 coffee bean oil extractFL/FR
 coffee difuranFL/FR
 coffee resinoidFL/FR
 furfuryl mercaptanFL/FR
1-hydroxy-2-butanoneFL/FR
2-methyl-3-,5 or 6-(furfuryl thio) pyrazineFL/FR
 popcorn pyrimidineFL/FR
 nutty pyrazineFL/FR
 tropical thiazoleFL/FR
green
2-heptyl furanFL/FR
herbal
 wormwood oil americaFL/FR
 wormwood oil italyFL/FR
 wormwood oil polandFL/FR
medicinal
2,6-xylenolFL/FR
 menthofuranFL/FR
 strawberry furanone methyl etherFL/FR
nutty
3-acetyl pyridineFL/FR
2-acetyl-3-ethyl pyrazineFL/FR
2-acetyl-3-methyl pyrazineFL/FR
2-acetyl-3,5(or 6)-dimethyl pyrazineFL/FR
3,6-cocoa pyrazineFL/FR
3,5-cocoa pyrazineFL/FR
2,3-dimethyl pyrazineFL/FR
4,5-dimethyl-2-ethyl-3-thiazolineFL/FR
2-ethyl pyrazineFL/FR
2-ethyl-4-methyl thiazoleFL/FR
 filbert heptenoneFL/FR
 filbert heptenone BFL/FR
 filbert pyrazineFL/FR
5-methyl quinoxalineFL/FR
 nutty quinoxalineFL/FR
 sesame absoluteFL/FR
 sesame absolute CO2 extractFL/FR
phenolic
para-alpha-dimethyl styreneFL/FR
popcorn
2-acetyl pyrazineFL/FR
2-acetyl pyridineFL/FR
2-acetyl thiazoleFL/FR
 fenugreek resinoidFL/FR
 trigonella foenum-graecum seed oil CO2 extractFL/FR
sulfurous
 benzothiazoleFL/FR
 dimethyl sulfideFL/FR
 furfuryl thioacetateFL/FR
S-furfuryl thioformateFL/FR
2-methyl 5-(methyl thio) furanFL/FR
3-thiohexanolFL/FR
sweet
2-hydroxy-3,4,5-trimethyl-2-cyclopenten-1-oneFL/FR
vegetable
1-furfuryl pyrroleFL/FR
woody
 juniper berry oleoresinFL/FR
 
For Flavor
 
No flavor group found for these
2-acetyl-2-pyrrolineFL
2-acetyl-3-methyl pyrazineFL/FR
6,7-dihydro-2,3-dimethyl-5H-cyclopentapyrazineFL
 dimethyl dihydrocyclopentapyrazineFL
2,5-dimethyl thiazoleFL
2,5-dimethyl-3-thiofuroyl furanFL
 ethyl dimethyl pyrazineFL
2-formyl pyrroleFL
2-hydroxy-3,4,5-trimethyl-2-cyclopenten-1-oneFL/FR
3-mercapto-3-methyl butyl formateFL
 methyl 2-(methyl thio) acetateFL
2-methyl-3-,5 or 6-(furfuryl thio) pyrazineFL/FR
2-propionyl pyrroleFL
 pyrazines mixtureFL
 sulfuryl butyrateFL/FR
 sulfuryl decanoateFL/FR
 sulfuryl hexanoateFL/FR
 sulfuryl isobutyrateFL/FR
 sulfuryl formateFL
 sulfuryl octanoateFL/FR
 sulfuryl propionateFL/FR
alliaceous
 benzyl mercaptanFL
 dicyclohexyl disulfideFL
 tropical thiazoleFL/FR
ammoniacal
2-methyl piperidineFL
bready
2-propionyl thiazoleFL
brown
 fenugreek oleoresinFL/FR
1-hydroxy-2-butanoneFL/FR
5-methyl furfuralFL/FR
burnt
 furfuryl alcoholFL
2-methyl quinoxalineFL
2,6-xylenolFL/FR
caramellic
 caramel furanone solutionFL/FR
 cycloteneFL/FR
 fenugreek resinoidFL/FR
coffee
 cichorium intybus root extractFL/FR
 cichorium intybus root solid extractFL/FR
 coffea arabica seed extractFL/FR
roasted coffea arabica seed extractFL/FR
 coffea arabica seed oilFL/FR
 coffee absoluteFL/FR
arabica coffee bean butterFL/FR
roasted arabica coffee bean essenceFL/FR
roasted coffee bean extractFL/FR
roasted arabica coffee bean oil CO2 extractFL/FR
 coffee bean oil extractFL/FR
 coffee difuranFL/FR
 coffee dioneFL/FR
 coffee distillatesFL
 coffee pyrazineFL
 coffee resinoidFL/FR
 difurfuryl etherFL
 diisoamyl thiomalateFL
2,4-dimethyl thiazoleFL
2-ethyl-4-methyl thiazoleFL/FR
 furfuryl mercaptanFL/FR
 methyl furfuryl disulfideFL/FR
 methyl furfuryl thiolFL
2-thiophene thiolFL
corn
2-acetyl pyridineFL/FR
2-acetyl thiazoleFL/FR
2-acetyl-2-thiazolineFL
 popcorn pyrimidineFL/FR
earthy
 difurfuryl sulfideFL
fatty
2-heptyl furanFL/FR
fishy
4,5-dimethyl thiazoleFL
fruity
 furfuryl isobutyrateFL
 furfuryl isovalerateFL
 furfuryl propionateFL
fusel
2-methyl butyraldehydeFL/FR
green
2-methyl-5-isopropyl pyrazineFL
herbal
 wormwood oil americaFL/FR
 wormwood oil italyFL/FR
 wormwood oil polandFL/FR
malty
 yeast thiazolineFL
meaty
 benzothiazoleFL/FR
3-mercapto-2-butanoneFL
2-methyl 3-(methyl thio) furanFL
molasses
 molasses blackstrapFL
mustard
 furfuryl methyl etherFL
musty
2,5-dimethyl pyrazineFL/FR
2,3-dimethyl pyrazineFL/FR
2-ethoxythiazoleFL
 menthofuranFL/FR
2-methyl 5-(methyl thio) furanFL/FR
 strawberry furanone methyl etherFL/FR
nutty
2-acetyl furanFL/FR
3-acetyl pyridineFL/FR
2-acetyl-3-ethyl pyrazineFL/FR
2-acetyl-3,5(or 6)-dimethyl pyrazineFL/FR
3,6-cocoa pyrazineFL/FR
3,5-cocoa pyrazineFL/FR
2,6-dimethyl pyrazineFL/FR
4,5-dimethyl-2-ethyl-3-thiazolineFL/FR
2-ethyl pyrazineFL/FR
1-ethyl-2-acetyl pyrroleFL
 filbert heptenoneFL/FR
 filbert heptenone BFL/FR
 filbert pyrazineFL/FR
5-methyl quinoxalineFL/FR
 nutty pyrazineFL/FR
 nutty quinoxalineFL/FR
 nutty thiazoleFL
 sesame absoluteFL/FR
 sesame absolute CO2 extractFL/FR
2,4,5-trimethyl thiazoleFL/FR
onion
 furfuryl isopropyl sulfideFL
popcorn
2-propionyl-2-thiazolineFL
roasted
2-acetyl pyrazineFL/FR
roasted arabica coffee bean oilFL/FR
 ethyl 3-(furfuryl thio) propionateFL
 furfuryl thioacetateFL/FR
 trigonella foenum-graecum seed oil CO2 extractFL/FR
solvent
2-ethyl furanFL
spicy
para-alpha-dimethyl styreneFL/FR
sulfurous
2,3-butane dithiolFL
 butyl mercaptanFL
 dimethyl sulfideFL/FR
 ethyl methyl sulfideFL
S-ethyl thioacetateFL
S-furfuryl thioformateFL/FR
 furfuryl thiopropionateFL
3-methyl-2-butane thiolFL
2-thienyl mercaptanFL
3-thiohexanolFL/FR
vegetable
1-furfuryl pyrroleFL/FR
woody
 juniper berry oleoresinFL/FR
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 coffee - up to 0.55 mg/kg
Search  Picture
 sesame seed roasted
Search Trop  Picture
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Synonyms:
2-acetyl-6-methylpyrazine
 ethanone, 1-(6-methyl-2-pyrazinyl)-
1-(6-methyl-2-pyrazinyl) ethanone
1-(6-methyl-2-pyrazinyl)-1-ethanone
1-(6-methyl-2-pyrazinyl)ethanone
1-(6-methylpyrazin-2-yl)ethanone
 pyrazine, 2-acetyl-6-methyl-
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Articles:
PubMed: Design, synthesis, and biological activities of novel hexahydropyrazino[1,2-a]indole derivatives as potent inhibitors of apoptosis (IAP) proteins antagonists with improved membrane permeability across MDR1 expressing cells.
PubMed: Characterization of the key odorants in pan-fried white mushrooms (Agaricus bisporus L.) by means of molecular sensory science: comparison with the raw mushroom tissue.
PubMed: 2,3,4-Triacet-oxy-1-[5-(1,2,3,4-tetra-acetoxy-butyl)pyrazin-2-yl]butyl acetate.
PubMed: Identification of potent odorants in different green tea varieties using flavor dilution technique.
PubMed: Studies on the key odorants formed by roasting of wild mango seeds (Irvingia gabonensis).
PubMed: Volatile flavor components of rice cakes.
PubMed: Amino acids and peptides. XL. Synthesis of Ac-Tyr-Val-Ala-Asp-MCA using newly developed acetylating reagent.
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