EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

butyramide
butanoic acid, amide

Supplier Sponsors

Name:butanamide
CAS Number: 541-35-5Picture of molecule3D/inchi
Other:42861-32-5
ECHA EINECS - REACH Pre-Reg:208-776-4
FDA UNII:9J6OR937VR
Nikkaji Web:J2.639E
Beilstein Number:1361528
MDL:MFCD00041894
XlogP3:-0.20 (est)
Molecular Weight:87.12193000
Formula:C4 H9 N O
NMR Predictor:Predict (works with chrome or firefox)
Category:flavoring agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
JECFA Food Flavoring:1593 butyramide
FEMA Number:4252 butyramide
FDA:No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF):541-35-5 ; BUTYRAMIDE
 
Physical Properties:
Appearance:white to pale yellow crystalline flakes (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 114.00 to 116.00 °C. @ 760.00 mm Hg
Boiling Point: 216.00 to 217.00 °C. @ 760.00 mm Hg
Vapor Pressure:0.143000 mmHg @ 25.00 °C. (est)
Flash Point:> 200.00 °F. TCC ( > 93.33 °C. )
logP (o/w): -0.210
Soluble in:
 alcohol
 water, 1.63E+05 mg/L @ 15 °C (exp)
 
Organoleptic Properties:
Odor Description:at 100.00 %. nutty
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Butyramide
EMD Millipore
For experimental / research use only.
Butyramide
Penta International
BUTYRAMIDE, Kosher
Santa Cruz Biotechnology
For experimental / research use only.
Butyramide
Sigma-Aldrich: Aldrich
For experimental / research use only.
Butyramide purum, ≥98.0% (T)
TCI AMERICA
For experimental / research use only.
Butyramide >98.0%(T)
 
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
Xn - Harmful.
R 22 - Harmful if swallowed.
R 36/37/38 - Irritating to eyes, respiratory system, and skin.
S 02 - Keep out of the reach of children.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: flavoring agents
Recommendation for butyramide usage levels up to:
 not for fragrance use.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 0.012 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 0.002 (μg/capita/day)
Modified Theoretical Added Maximum Daily Intake (mTAMDI): 200 (μg/person/day)
Threshold of Concern:540 (μg/person/day)
Structure Class: II
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 22
 average usual ppmaverage maximum ppm
baked goods: 1.000005.00000
beverages(nonalcoholic): --
beverages(alcoholic): --
breakfast cereal: 0.200001.00000
cheese: 0.400002.00000
chewing gum: --
condiments / relishes: 0.100000.50000
confectionery froastings: 1.000005.00000
egg products: --
fats / oils: 0.100000.50000
fish products: 0.200001.00000
frozen dairy: 0.400002.00000
fruit ices: 0.400002.00000
gelatins / puddings: --
granulated sugar: --
gravies: --
hard candy: --
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: 0.200001.00000
milk products: 0.400002.00000
nut products: --
other grains: 0.200001.00000
poultry: 0.200001.00000
processed fruits: 0.400002.00000
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: 0.100000.50000
snack foods: 1.000005.00000
soft candy: --
soups: 0.100000.50000
sugar substitutes: --
sweet sauces: --
 
Food categories according to Commission Regulation EC No. 1565/2000 (EC, 2000) in FGE.06 (EFSA, 2002a). According to the Industry the "normal" use is defined as the average of reported usages and "maximum use" is defined as the 95th percentile of reported usages (EFSA, 2002i).
Note: mg/kg = 0.001/1000 = 0.000001 = 1/1000000 = ppm.
 average usage mg/kgmaximum usage mg/kg
Dairy products, excluding products of category 02.0 (01.0): 0.400002.00000
Fats and oils, and fat emulsions (type water-in-oil) (02.0): 0.100000.50000
Edible ices, including sherbet and sorbet (03.0): 0.400002.00000
Processed fruit (04.1): 0.400002.00000
Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2): --
Confectionery (05.0): 1.000005.00000
Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0): 0.200001.00000
Bakery wares (07.0): 1.000005.00000
Meat and meat products, including poultry and game (08.0): 0.100000.40000
Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0): 0.100000.40000
Eggs and egg products (10.0): --
Sweeteners, including honey (11.0): --
Salts, spices, soups, sauces, salads, protein products, etc. (12.0): 0.100000.50000
Foodstuffs intended for particular nutritional uses (13.0): 0.200001.00000
Non-alcoholic ("soft") beverages, excl. dairy products (14.1): --
Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2): 1.000005.00000
Ready-to-eat savouries (15.0): 1.000005.00000
Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0): 0.200001.00000
 
Safety References:
European Food Safety Athority(efsa):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Flavouring Group Evaluation 86, (FGE.86)[1] - Consideration of aliphatic and aromatic amines and amides evaluated by JECFA (65th meeting) - Scientific Opinion of the Panel on Food Additives - Flavourings, Processing Aids and Materials in Contact with Food
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 86, Revision 1 (FGE.86Rev1): Consideration of aliphatic and aromatic amines and amides evaluated by JECFA (65th meeting)
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 86, Revision 2 (FGE.86Rev2): Consideration of aliphatic and arylalkyl amines and amides evaluated by JECFA (65th meeting)
View page or View pdf

EPI System: View
NLM Hazardous Substances Data Bank:Search
Cancer Citations:Search
Toxicology Citations:Search
Env. Mutagen Info. Center:Search
EPA Substance Registry Services (TSCA):541-35-5
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :10927
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
butanamide
Chemidplus:0000541355
 
References:
 butanamide
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:541-35-5
Pubchem (cid):10927
Pubchem (sid):134975938
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
CHEBI:View
CHEMBL:View
HMDB (The Human Metabolome Database):HMDB33870
FooDB:FDB012058
Export Tariff Code:2924.19.1150
Haz-Map:View
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
RSC Learn Chemistry:View
 
Potential Blenders and core components note
For Odor
No odor group found for these
sulfuryl octanoate
FL/FR
sulfuryl butyrate
FL/FR
sulfuryl decanoate
FL/FR
sulfuryl hexanoate
FL/FR
sulfuryl isobutyrate
FL/FR
sulfuryl propionate
FL/FR
valeraldehyde dibutyl acetal
FL/FR
valeraldehyde propylene glycol acetal
FL/FR
balsamic
balsamic
propyl benzoate
FL/FR
buttery
acetyl propionyl
FL/FR
3,4-
hexane dione
FL/FR
camphoreous
bornyl isobutyrate
FL/FR
caramellic
ethyl 2-hydroxy-2-methyl butyrate
FL/FR
chocolate
chocolate pyrazine A
FL/FR
2-
methoxypyrazine
FL/FR
2-
methyl butyraldehyde
FL/FR
coconut
alpha-
angelica lactone
FL/FR
gamma-
heptalactone
FL/FR
coumarinic
coumane
FL/FR
tonka bean resinoid
FR
earthy
2-
ethyl-3-methoxypyrazine
FL/FR
fatty
coconut absolute
FL/FR
fermented
valeraldehyde
FL/FR
floral
boronia butenal
FR
para-
cresyl laurate
FL/FR
fruity
allyl 2-ethyl butyrate
FL/FR
iso
amyl nonanoate
FL/FR
methyl valerate
FL/FR
3-
methyl-2-butenal
FL/FR
green
2-
heptyl furan
FL/FR
tiglaldehyde
FL/FR
herbal
saffron pyranone
FR
musty
2-
acetyl pyrrole
FL/FR
3-
acetyl-2,5-dimethyl furan
FL/FR
hazelnut pyrazine
FL/FR
menthofuran
FL/FR
naphthyl
para-
methyl anisole
FL/FR
ortho-
methyl anisole
FL/FR
nutty
3-
acetyl pyridine
FL/FR
2-
acetyl-3-ethyl pyrazine
FL/FR
2-
acetyl-3-methyl pyrazine
FL/FR
2-
acetyl-3,5-dimethyl pyrazine
FL/FR
2-
acetyl-5-methyl furan
FL/FR
3,6-
cocoa pyrazine
FL/FR
2,3-
dimethyl pyrazine
FL/FR
2-
ethyl pyrazine
FL/FR
2-
ethyl-4-methyl thiazole
FL/FR
filbert heptenone
FL/FR
filbert pyrazine
FL/FR
2,6-
lutidine
FL/FR
maraniol
CS
2-
methyl pyrazine
FL/FR
5-
methyl quinoxaline
FL/FR
2-
methyl thio-3,5 or 6-methyl pyrazine
FL/FR
2-
methyl-3-(methyl thio) pyrazine
FL/FR
2-
methyl-3-ethoxypyrazine
FL/FR
2-
methyl-3-propyl pyrazine
FL/FR
nutty cyclohexenone
FL/FR
nutty quinoxaline
FL/FR
shoyu pyrazine
FL/FR
2,3,5,6-
tetramethyl pyrazine
FL/FR
2,3,5-
trimethyl pyrazine
FL/FR
vinyl sulfurol
FL/FR
popcorn
2-
acetyl pyrazine
FL/FR
2-
acetyl thiazole
FL/FR
sulfurous
furfuryl thioacetate
FL/FR
tobacco
veltonal (Bedoukian)
FR
tonka
tonka bean absolute
FR
whiskey lactone
FL/FR
woody
sandalwood oil
FL/FR
For Flavor
No flavor group found for these
acetyl acetaldehyde dimethyl acetal
FL
bornyl isobutyrate
FL/FR
chocolate pyrazine A
FL/FR
coumane
FL/FR
cyclohexyl methyl pyrazine
FL
2,5-
diethyl thiazole
FL
2,5-
diethyl-4-methyl thiazole
FL
6,7-
dihydro-2,3-dimethyl-5H-cyclopentapyrazine
FL
dimethyl dihydrocyclopentapyrazine
FL
2,5-
dimethyl thiazole
FL
ethyl 2-hydroxy-2-methyl butyrate
FL/FR
2-
ethyl-3-methoxypyrazine
FL/FR
(Z+E)-5-
ethyl-4-methyl-2-(2-butyl) thiazoline
FL
(Z+E)-5-
ethyl-4-methyl-2-(2-methyl propyl) thiazoline
FL
3-(2-
furyl) acrolein
FL
(E,E)-2,4-
heptadien-1-ol
FL
2-
hexyl-5 or 6-keto-1,4-dioxane
FL
2-
methoxypyrazine
FL/FR
2-
methyl-3-(methyl thio) pyrazine
FL/FR
2-
methyl-3-ethoxypyrazine
FL/FR
peanut dithiazine
FL
2-
propyl pyridine
FL
para-
salicylic acid
FL
sulfuryl butyrate
FL/FR
sulfuryl decanoate
FL/FR
sulfuryl hexanoate
FL/FR
sulfuryl isobutyrate
FL/FR
thiazole
FL
valeraldehyde propylene glycol acetal
FL/FR
5-
acetyl-2,3-dihydro-1,4-thiazine
FL
sulfuryl formate
FL
sulfuryl octanoate
FL/FR
sulfuryl propionate
FL/FR
valeraldehyde dibutyl acetal
FL/FR
alliaceous
alliaceous
2-
methyl thioacetaldehyde
FL
bready
2-
propionyl thiazole
FL
burnt
2-
methyl quinoxaline
FL
buttery
3,4-
hexane dione
FL/FR
camphoreous
ortho-
methyl anisole
FL/FR
coffee
difurfuryl ether
FL
2-
ethyl-4-methyl thiazole
FL/FR
2-iso
propyl pyrazine
FL
corn chip
2-
acetyl thiazole
FL/FR
2-
acetyl-2-thiazoline
FL
creamy
alpha-
angelica lactone
FL/FR
earthy
2-
methyl-3-propyl pyrazine
FL/FR
ethereal
allyl 2-ethyl butyrate
FL/FR
fatty
coconut absolute
FL/FR
2-
heptyl furan
FL/FR
(E,E)-2,4-
nonadienal
FL
fishy
4,5-
dimethyl thiazole
FL
fruity
2,4-
hexadien-1-ol
FL
methyl valerate
FL/FR
3-
methyl-2-butenal
FL/FR
propyl benzoate
FL/FR
tiglaldehyde
FL/FR
fusel
2-
methyl butyraldehyde
FL/FR
green
2,5-
dimethyl thiophene
FL
4-
methyl thiazole
FL
2-
methyl-5-isopropyl pyrazine
FL
2-
vinyl pyrazine
FL
lactonic
gamma-
heptalactone
FL/FR
musty
hazelnut pyrazine
FL/FR
menthofuran
FL/FR
shoyu pyrazine
FL/FR
2,3,5-
trimethyl pyrazine
FL/FR
naphthyl
para-
methyl anisole
FL/FR
nutty
3-
acetyl pyridine
FL/FR
2-
acetyl pyrrole
FL/FR
3-
acetyl-2,5-dimethyl furan
FL/FR
2-
acetyl-3-ethyl pyrazine
FL/FR
2-
acetyl-3-methyl pyrazine
FL/FR
2-
acetyl-3,5-dimethyl pyrazine
FL/FR
2-
acetyl-5-methyl furan
FL/FR
aconitic acid
FL
3,6-
cocoa pyrazine
FL/FR
3,5-
diethyl-2-methyl pyrazine
FL
2,5-
diethyl-3-methyl pyrazine
FL
2,3-
dimethyl pyrazine
FL/FR
2,4-
dimethyl-5-vinyl thiazole
FL
2-
ethyl pyrazine
FL/FR
1-
ethyl-2-acetyl pyrrole
FL
filbert heptenone
FL/FR
filbert pyrazine
FL/FR
european
hazelnut oleoresin
FL
2,6-
lutidine
FL/FR
2-
methyl pyrazine
FL/FR
5-
methyl quinoxaline
FL/FR
2-
methyl thio-3,5 or 6-methyl pyrazine
FL/FR
nutty cyclohexenone
FL/FR
nutty quinoxaline
FL/FR
nutty thiazole
FL
peanut oxazole
FL
2,3,5,6-
tetramethyl pyrazine
FL/FR
vinyl sulfurol
FL/FR
popcorn
2-
propionyl-2-thiazoline
FL
roasted
2-
acetyl pyrazine
FL/FR
furfuryl thioacetate
FL/FR
toasted
acetyl propionyl
FL/FR
waxy
para-
cresyl laurate
FL/FR
winey
iso
amyl nonanoate
FL/FR
5-
ethyl-2-methyl pyridine
FL
valeraldehyde
FL/FR
woody
sandalwood oil
FL/FR
whiskey lactone
FL/FR
 
Potential Uses:
FLcereal
FLcheese
FLdairy
FLfish
FRfruit
FLmeat
 
Occurrence (nature, food, other):note
 cheese
Search PMC Picture
 
Synonyms:
 butanamide
N-butanamide
 butanimidic acid
 butanoic acid amide
 butanoic acid, amide
 butylamide
N-butylamide
N-butyramide
 butyrylamide
 ethylacetamide
 

Articles:

Info:aliphatic and aromatic amines and amides
PubMed:Transport characteristics of urea transporter-B.
PubMed:Profile of anticonvulsant action of levetiracetam, tiagabine and phenobarbital against seizures evoked by DMCM (methyl-6,7-dimethoxy-4-ethyl-β-carboline-3-carboxylate) in neonatal rats.
PubMed:Lead discovery and in silico 3D structure modeling of tumorigenic FAM72A (p17).
PubMed:Potentially bioactive organotin(IV) compounds: synthesis, characterization, in vitro bioactivities and interaction with SS-DNA.
PubMed:Synthesis and characterization of [N-methyl-3H]loperamide.
PubMed:Interaction and dynamics of (alkylamide + electrolyte) deep eutectics: dependence on alkyl chain-length, temperature, and anion identity.
PubMed:N-aryl-2,6-dimethylbenzamides, a new generation of tocainide analogues as blockers of skeletal muscle voltage-gated sodium channels.
PubMed:Interaction between brivaracetam (100 mg/day) and a combination oral contraceptive: a randomized, double-blind, placebo-controlled study.
PubMed:Brivaracetam as adjunctive treatment for uncontrolled partial epilepsy in adults: a phase III randomized, double-blind, placebo-controlled trial.
PubMed:Effect of brivaracetam (400 mg/day) on the pharmacokinetics and pharmacodynamics of a combination oral contraceptive in healthy women.
PubMed:Adjunctive brivaracetam in adults with uncontrolled focal epilepsy: results from a double-blind, randomized, placebo-controlled trial.
PubMed:Adjunctive brivaracetam for uncontrolled focal and generalized epilepsies: results of a phase III, double-blind, randomized, placebo-controlled, flexible-dose trial.
PubMed:N-Butanoyl-N-(3-chloro-1,4-dioxonaph-thalen-2-yl)butanamide.
PubMed:Molecular structure, normal coordinate analysis, harmonic vibrational frequencies, NBO, HOMO-LUMO analysis and detonation properties of (S)-2-(2-oxopyrrolidin-1-yl) butanamide by density functional methods.
PubMed:Chemical-physical analysis of a tartrate model compound for TACE inhibition.
PubMed:Two- and three-dimensional assembled structures constructed from amidate-bridged paddlewheel complexes with group 6 oxometallate ions.
PubMed:Teratology study of amide derivatives of branched aliphatic carboxylic acids with 4-aminobenzensulfonamide in NMRI mice.
PubMed:Identification and structure elucidation of a novel antifungal compound produced by Pseudomonas aeruginosa PGPR2 against Macrophomina phaseolina.
PubMed:The importance of screening solid-state phases of a racemic modification of a chiral drug: thermodynamic and structural characterization of solid-state phases of etiracetam.
PubMed:Effects of sodium butyrate and its synthetic amide derivative on liver inflammation and glucose tolerance in an animal model of steatosis induced by high fat diet.
PubMed:Determination of trace levels of acetamide, propanamide, and butyramide in surface and drinking water using gas chromatography-mass spectrometry after derivatization with 9-xanthydrol.
PubMed:Hits of a high-throughput screen identify the hydrophobic pocket of autotaxin/lysophospholipase D as an inhibitory surface.
PubMed:An unexpected Dimroth rearrangement leading to annelated thieno[3,2-d][1,2,3]triazolo[1,5-a]pyrimidines with potent antitumor activity.
PubMed:Purification and characterization of a novel thermo-active amidase from Geobacillus subterraneus RL-2a.
PubMed:Brivaracetam disposition in mild to severe hepatic impairment.
PubMed:Cations bind only weakly to amides in aqueous solutions.
PubMed:1H and 13C NMR analysis of 2-acetamido-3-mercapto-3-methyl-N-aryl-butanamides and 2-acetamido-3-methyl-3-nitrososulfanyl-N-aryl-butanamide derivatives.
PubMed:Preparation, spectroscopic investigation and antiproliferative capacity of new metal complexes of (3E)-2-(hydroxyimino)-N-P-Tolyl-3-(P-tolylimino) butanamide.
PubMed:[Synthesis and activities of 4-(2-acetoxybenzoylamino) butyramide heterocyclic compounds].
PubMed:[123I]Iodooctyl fenbufen amide as a SPECT tracer for imaging tumors that over-express COX enzymes.
PubMed:N-(Phenoxyalkyl)amides as MT(1) and MT(2) ligands: antioxidant properties and inhibition of Ca(2+)/CaM-dependent kinase II.
PubMed:Novel series of 3-amino-N-(4-aryl-1,1-dioxothian-4-yl)butanamides as potent and selective dipeptidyl peptidase IV inhibitors.
PubMed:The chiral herbicide beflubutamid (II): Enantioselective degradation and enantiomerization in soil, and formation/degradation of chiral metabolites.
PubMed:Synthesis, biological evaluation and docking studies of new pyrrolo[2,3-d] pyrimidine derivatives as Src family-selective tyrosine kinase inhibitors.
PubMed:Target binding properties and cellular activity of afatinib (BIBW 2992), an irreversible ErbB family blocker.
PubMed:The chiral herbicide beflubutamid (I): Isolation of pure enantiomers by HPLC, herbicidal activity of enantiomers, and analysis by enantioselective GC-MS.
PubMed:Solid-liquid phase diagrams for the determination of the solid state nature of both polymorphs of (RS)-2-(2-oxo-pyrrolidin-1-yl)-butyramide.
PubMed:Efficacy and tolerability of adjunctive brivaracetam in adults with uncontrolled partial-onset seizures: a phase IIb, randomized, controlled trial.
PubMed:Discovery of a series of 2-phenyl-N-(2-(pyrrolidin-1-yl)phenyl)acetamides as novel molecular switches that modulate modes of K(v)7.2 (KCNQ2) channel pharmacology: identification of (S)-2-phenyl-N-(2-(pyrrolidin-1-yl)phenyl)butanamide (ML252) as a potent, brain penetrant K(v)7.2 channel inhibitor.
PubMed:Tritium-labeled brivaracetam with high specific activity: preparation, characterization and application in human brain samples.
PubMed:N-[4-(4-Bromo-phen-yl)thia-zol-2-yl]-4-(piperidin-1-yl)butanamide.
PubMed:Isolation and characterization of Kluyvera georgiana strain with the potential for acrylamide biodegradation.
PubMed:Appraisal of GABA and PABA as linker: design and synthesis of novel benzamide based histone deacetylase inhibitors.
PubMed:Effect of gemfibrozil on the metabolism of brivaracetam in vitro and in human subjects.
PubMed:Synthesis, in vitro and in vivo characterization of novel 99mTc-'4+1'-labeled 5-nitroimidazole derivatives as potential agents for imaging hypoxia.
PubMed:MK-626, a dipeptidyl peptidase-4 inhibitor, does not improve the hyperglycemia or hyperinsulinemia of nonobese diabetic MKR mice.
PubMed:[Design, synthesis and activities of 4-(2-acetoxybenzoylamino) butyramide derivatives].
PubMed:NAHA, a novel hydroxamic acid-derivative, inhibits growth and angiogenesis of breast cancer in vitro and in vivo.
PubMed:Redetermination of loperamide monohydrate.
PubMed:N,N'-(1,4-Phenyl-ene)bis-(4-chloro-butanamide).
PubMed:Design, synthesis, and evaluation of novel 4-thiazolylimidazoles as inhibitors of transforming growth factor-β type I receptor kinase.
PubMed:Differential effects between γ-secretase inhibitors and modulators on cognitive function in amyloid precursor protein-transgenic and nontransgenic mice.
PubMed:Brivaracetam disposition in renal impairment.
PubMed:The role of odour quality in the perception of binary and higher-order mixtures.
PubMed:2-[2-(2-Carb-oxy-phen-yl)hydrazinyl-idene]-3-oxo-N-phenyl-butyramide.
PubMed:Structurally distinct nicotine immunogens elicit antibodies with non-overlapping specificities.
PubMed:2,2-Diphenyl-4-(piperidin-1-yl)butanamide.
PubMed:Magnaporthe oryzae cell wall hydrolysate induces ROS and fungistatic VOCs in rice cell cultures.
PubMed:Process for detecting Helicobacter pylori using aliphatic amides.
PubMed:A new cytotoxic indole-3-ethenamide from the halotolerant fungus Aspergillus sclerotiorum PT06-1.
PubMed:SBA-15-type organosilica with 4-mercapto-N,N-bis-(3-Si-propyl)butanamide for palladium scavenging and cross-coupling catalysis.
PubMed:Brivaracetam for the treatment of epilepsy.
PubMed:Binding characteristics of brivaracetam, a selective, high affinity SV2A ligand in rat, mouse and human brain: relationship to anti-convulsant properties.
PubMed:N-(4-Butanoyl-3-hy-droxy-phen-yl)butanamide.
PubMed:Biodegradation of acrylamide by Enterobacter aerogenes isolated from wastewater in Thailand.
PubMed:Biosynthesis of 2-amino-2,3-dimethylbutyramide by nitrile hydratase from a newly isolated cyanide-resistant strain of Rhodococcus qingshengii.
PubMed:Synthesis of biologically active 1'-(2-oxo-2H-benzopyran-6-yl)- 5'-hydroxy-2'-methylindole-3'-amido-2"-phenyl-thiazolidene-4"-ones.
PubMed:Novel ferrocenyl nitroxide nanoparticles as electron paramagnetic resonance oximetry probes in vitro and in vivo.
PubMed:Challenges in the development of hydrate phases as active pharmaceutical ingredients--an example.
PubMed:A new acylamidase from Rhodococcus erythropolis TA37 can hydrolyze N-substituted amides.
PubMed:Cytochrome P450 1 enzyme inhibition and anticancer potential of chromene amides from Amyris plumieri.
PubMed:Increased compactibility of acetames after roll compaction.
PubMed:Neurocognitive effects of brivaracetam, levetiracetam, and lorazepam.
PubMed:Synthesis of the sponge-derived plakortone series of bioactive compounds.
PubMed:New technology for the investigation of water vapor sorption-induced crystallographic form transformations of chemical compounds: a water vapor sorption gravimetry-dispersive Raman spectroscopy coupling.
PubMed:Brivaracetam does not alter spatial learning and memory in both normal and amygdala-kindled rats.
PubMed:Levetiracetam in brain ischemia: clinical implications in neuroprotection and prevention of post-stroke epilepsy.
PubMed:Mitogen-activated protein kinase activated protein kinase 2 (MK2) participates in p38 MAPK regulated control of oligodendrocyte differentiation.
PubMed:Adjunctive brivaracetam for refractory partial-onset seizures: a randomized, controlled trial.
PubMed:Direct assay of delta-aminolevulinic acid dehydratase in heme biosynthesis for the detection of porphyrias by tandem mass spectrometry.
PubMed:Simultaneous determination of amitraz and its metabolite residue in food animal tissues by gas chromatography-electron capture detector and gas chromatography-mass spectrometry with accelerated solvent extraction.
PubMed:Effect of the size of electrode on electrochemical properties of ferrocene-functionalized polypyrrole towards DNA sensing.
PubMed:Syntheses and evaluation of anticonvulsant profile and teratogenicity of novel amide derivatives of branched aliphatic carboxylic acids with 4-aminobenzensulfonamide.
PubMed:Biocatalytic amidation of carboxylic acids and their antinemic activity.
PubMed:Reinforced thermoplastic polyimide with dispersed functionalized single wall carbon nanotubes.
PubMed:Discovery of novel (S)-alpha-phenyl-gamma-amino butanamide containing CCR5 antagonists via functionality inversion approach.
PubMed:Physiologically based pharmacokinetic/pharmacodynamic animal-to-man prediction of therapeutic dose in a model of epilepsy.
PubMed:Levetiracetam inhibits interleukin-1 beta inflammatory responses in the hippocampus and piriform cortex of epileptic rats.
PubMed:4-Aryl-4-oxo-N-phenyl-2-aminylbutyramides as acetyl- and butyrylcholinesterase inhibitors. Preparation, anticholinesterase activity, docking study, and 3D structure-activity relationship based on molecular interaction fields.
PubMed:Absolute configuration of odorine.
PubMed:2-Amino-2,3-dimethyl-butanamide.
PubMed:1-(4-Bromo-phen-yl)-3-butano-ylthio-urea.
PubMed:Discovery of indolone acetamides as novel SV2A ligands with improved potency toward seizure suppression.
PubMed:What is the promise of new antiepileptic drugs in status epilepticus? Focus on brivaracetam, carisbamate, lacosamide, NS-1209, and topiramate.
PubMed:Novel polyaromatic-terminated transition metal complexes for the functionalization of carbon surfaces.
PubMed:Brivaracetam (ucb 34714) inhibits Na(+) current in rat cortical neurons in culture.
PubMed:Synthesis, cytotoxicity by bioluminescence inhibition, antibacterial and antifungal activity of ([1,2,4]Triazolo[1,5-c]quinazolin-2-ylthio)carboxylic acid amides.
PubMed:Novel pyridine derivatives as potent and selective CB2 cannabinoid receptor agonists.
PubMed:Growth hormone secretagogues and growth hormone releasing peptides act as orthosteric super-agonists but not allosteric regulators for activation of the G protein Galpha(o1) by the Ghrelin receptor.
PubMed:Species enrichment of SWNTs with pyrene alkylamide derivatives: is the alkyl chain length important?
PubMed:Design, synthesis and pharmacological evaluation of 6-hydroxy-4-methylquinolin-2(1H)-one derivatives as inotropic agents.
PubMed:Chemical and biological characterization of thiol SAMs for neuronal cell attachment.
PubMed:Characterization of a novel mitogen-activated protein kinase kinase 1/2 inhibitor with a unique mechanism of action for cancer therapy.
PubMed:Brivaracetam inhibits spreading depression in rat neocortical slices in vitro.
PubMed:3-(1,3-Dithio-lan-2-yl-idene)-1-phenyl-pyridine-2,4(1H,3H)-dione.
PubMed:N-(3,4-Dichloro-phen-yl)-3-oxo-butanamide.
PubMed:Brivaracetam and seletracetam, two new SV2A ligands, improve paroxysmal dystonia in the dt sz mutant hamster.
PubMed:Overlapping binding site for the endogenous agonist, small-molecule agonists, and ago-allosteric modulators on the ghrelin receptor.
PubMed:(3R)-3-amino-4-(2,4,5-trifluorophenyl)-N-{4-[6-(2-methoxyethoxy)benzothiazol-2-yl]tetrahydropyran-4-yl}butanamide as a potent dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.
PubMed:Polyhydroxyethylaspartamide-spermine copolymers: efficient vectors for gene delivery.
PubMed:[3H]BMS-599240--a novel tritiated ligand for the characterization of BACE1 inhibitors.
PubMed:Effect of brivaracetam on cardiac repolarisation--a thorough QT study.
PubMed:Synthesis of DL-fluorobenzenamides as anticonvulsants.
PubMed:Anti-convulsive and anti-epileptic properties of brivaracetam (ucb 34714), a high-affinity ligand for the synaptic vesicle protein, SV2A.
PubMed:Synthesis of DL-hydroxybenzenamides as anticonvulsants.
PubMed:Functional human 5-HT6 receptor assay for high throughput screening of chemical ligands and binding proteins.
PubMed:Reversal of GABA-mediated inhibition of the electrically and potassium chloride evoked [3H]-GABA release from rat substantia nigra slices by DL-3-hydroxy-3-phenyl pentanamide.
PubMed:R-stereoselective amidase from Rhodococcus erythropolis No. 7 acting on 4-chloro-3-hydroxybutyramide.
PubMed:The pharmacokinetics, CNS pharmacodynamics and adverse event profile of brivaracetam after multiple increasing oral doses in healthy men.
PubMed:Stereoselective total synthesis of (+)-cardiobutanolide.
PubMed:Brivaracetam: a new drug in development for epilepsy and neuropathic pain.
PubMed:2-(4-Chloro-phen-yl)-3-methyl-N-(5-methyl-thia-zol-2-yl)butanamide.
PubMed:N-(4-Chloro-phen-yl)-4-(2-oxocyclo-pent-yl)butyramide.
PubMed:N-(Benzothia-zol-2-yl)butyramide.
PubMed:Inhibitory effects of synthetic somatostatin receptor subtype 4 agonists on acute and chronic airway inflammation and hyperreactivity in the mouse.
PubMed:Novel fluorinated derivatives of the broad-spectrum MMP inhibitors N-hydroxy-2(R)-[[(4-methoxyphenyl)sulfonyl](benzyl)- and (3-picolyl)-amino]-3-methyl-butanamide as potential tools for the molecular imaging of activated MMPs with PET.
PubMed:Pharmacokinetics and metabolism of 14C-brivaracetam, a novel SV2A ligand, in healthy subjects.
PubMed:Evaluation of brivaracetam, a novel SV2A ligand, in the photosensitivity model.
PubMed:Brivaracetam is superior to levetiracetam in a rat model of post-hypoxic myoclonus.
PubMed:Molecular interaction of a potent nonpeptide agonist with the chemokine receptor CCR8.
PubMed:Cellular mechanisms involved in the melatonin inhibition of HT-29 human colon cancer cell proliferation in culture.
PubMed:Antiepileptic drug-induced neuronal cell death in the immature brain: effects of carbamazepine, topiramate, and levetiracetam as monotherapy versus polytherapy.
PubMed:Metabolite profiling of [14C]hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) in Yucatan miniature pigs.
PubMed:Stereoselective total synthesis of bioactive styryllactones (+)-goniofufurone, (+)7-epi-goniofufurone, (+)-goniopypyrone, (+)-goniotriol, (+)-altholactone, and (-)-etharvensin.
PubMed:Comparative transport efficiencies of urea analogues through urea transporter UT-B.
PubMed:Investigation into the P3 binding domain of m-calpain using photoswitchable diazo- and triazene-dipeptide aldehydes: new anticataract agents.
PubMed:Synthesis and anticonvulsant activity of 4-(2-(2,6-dimethylphenylamino)-2-oxoethylamino)-N-(substituted)butanamides: a pharmacophoric hybrid approach.
PubMed:High performance liquid chromatographic studies on lanthanides, uranium and thorium on amide modified reversed phase supports.
PubMed:Reduction of site-specific CYP3A-mediated metabolism for dual angiotensin and endothelin receptor antagonists in various in vitro systems and in cynomolgus monkeys.
PubMed:[A new aspect in the research on antiepileptic drugs].
PubMed:The pharmacokinetics, CNS pharmacodynamics and adverse event profile of brivaracetam after single increasing oral doses in healthy males.
PubMed:Bioconversion of butyronitrile to butyramide using whole cells of Rhodococcus rhodochrous PA-34.
PubMed:Effect of culture conditions on antifouling compound production of a sponge-associated fungus.
PubMed:Isofagomine- and 2,5-anhydro-2,5-imino-D-glucitol-based glucocerebrosidase pharmacological chaperones for Gaucher disease intervention.
PubMed:Brivaracetam (UCB 34714).
PubMed:3-[2-((2S)-2-cyano-pyrrolidin-1-yl)-2-oxo-ethylamino]-3-methyl-butyramide analogues as selective DPP-IV inhibitors for the treatment of type-II diabetes.
PubMed:Characterization of a higher plant herbicide-resistant phytoene desaturase and its use as a selectable marker.
PubMed:Stabilization of liposomes through enzymatic polymerization of DNA.
PubMed:Alpha-aminothiazole-gamma-aminobutanoic amides as potent, small molecule CCR2 receptor antagonists.
PubMed:Effects of the somatostatin receptor subtype 4 selective agonist J-2156 on sensory neuropeptide release and inflammatory reactions in rodents.
PubMed:Novel, orally bioavailable gamma-aminoamide CC chemokine receptor 2 (CCR2) antagonists.
PubMed:4-Amino-2-alkyl-butyramides as small molecule CCR2 antagonists with favorable pharmacokinetic properties.
PubMed:Transferable potentials for phase equilibria. 7. Primary, secondary, and tertiary amines, nitroalkanes and nitrobenzene, nitriles, amides, pyridine, and pyrimidine.
PubMed:(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-(4-[1,2,4]triazolo[1,5-a]-pyridin-6-ylphenyl)butanamide: a selective alpha-amino amide dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.
PubMed:Analgesic effects of the somatostatin sst4 receptor selective agonist J-2156 in acute and chronic pain models.
PubMed:Binding characteristics of levetiracetam to synaptic vesicle protein 2A (SV2A) in human brain and in CHO cells expressing the human recombinant protein.
PubMed:Solubilization and immunopurification of rat brain synaptic vesicle protein 2A with maintained binding properties.
PubMed:Differential efficacies of somatostatin receptor agonists for G-protein activation and desensitization of somatostatin receptor subtype 4-mediated responses.
PubMed:Synthesis of uniform protein-polymer conjugates.
PubMed:Structure-based drug design to the discovery of new 2-aminothiazole CDK2 inhibitors.
PubMed:Application of Fourier transform infrared spectroscopy for monitoring hydrolysis and synthesis reactions catalyzed by a recombinant amidase.
PubMed:Characterization of [(3)H]ucb 30889 binding to synaptic vesicle protein 2A in the rat spinal cord.
PubMed:Brivaracetam UCB.
PubMed:Structural and orientational studies of chiral N-[4(1-pyrene)butyroyl]-phenylalanine in cast film.
PubMed:Activity coefficients and thermodynamic parameters for RbCl/CsCl + amide (acetamide, propanamide, and n-butanamide) + water system at 298.15 K.
PubMed:Assay of acebutolol in pharmaceuticals by analytical capillary isotachophoresis.
PubMed:Physical stability of the amorphous state of loperamide and two fragment molecules in solid dispersions with the polymers PVP-K30 and PVP-VA64.
PubMed:Synthesis, radiosynthesis, in vitro and preliminary in vivo evaluation of biphenyl carboxylic and hydroxamic matrix metalloproteinase (MMP) inhibitors as potential tumor imaging agents.
PubMed:Synthesis and pharmacological evaluation of some DL-dichlorophenyl alcohol amides anticonvulsants.
PubMed:2,4,6-trisubstituted pyrimidines as a new class of selective adenosine A1 receptor antagonists.
PubMed:Neuroprotective effects of ONO-1924H, an inhibitor of poly ADP-ribose polymerase (PARP), on cytotoxicity of PC12 cells and ischemic cerebral damage.
PubMed:A validated chiral LC method for the enantioselective analysis of Levetiracetam and its enantiomer R-alpha-ethyl-2-oxo-pyrrolidine acetamide on amylose-based stationary phase.
PubMed:Superagonism at the human somatostatin receptor subtype 4.
PubMed:Tricyclic alkylamides as melatonin receptor ligands with antagonist or inverse agonist activity.
PubMed:Development of a spectroscopic assay for bifunctional ligand-protein conjugates based on copper.
PubMed:Sterically and guest-controlled self-assembly of calix[4]arene derivatives.
PubMed:[Synthesis of prodrugs of tacrine hydrochloride and evaluation of the stability and biodistribution in mice].
PubMed:Discovery of 4-substituted pyrrolidone butanamides as new agents with significant antiepileptic activity.
PubMed:General pharmacology of the butanamide derivative S 19812, a new dual inhibitor of cyclooxygenase and lipoxygenase pathways.
PubMed:Synthesis of the butanamide derivative S 19812, a new dual inhibitor of cyclooxygenase and lipoxygenase pathways.
PubMed:Localization and photoaffinity labelling of the levetiracetam binding site in rat brain and certain cell lines.
PubMed:Binding characteristics of [3H]ucb 30889 to levetiracetam binding sites in rat brain.
PubMed:Simultaneous determination of N-butyramide-tacrine and tacrine in mouse plasma and brain homogenate by high-performance liquid chromatography with a simple gradient solvent system.
PubMed:Design and synthesis of highly potent benzodiazepine gamma-secretase inhibitors: preparation of (2S,3R)-3-(3,4-difluorophenyl)-2-(4-fluorophenyl)-4- hydroxy-N-((3S)-1-methyl-2-oxo-5- phenyl-2,3-dihydro-1H-benzo[e][1,4]-diazepin-3-yl)butyramide by use of an asymmetric Ireland-Claisen rearrangement.
PubMed:[Synthesis of new N3S pseudo-peptide complexes and biodistribution in mice].
PubMed:(R)-2,4-Dihydroxybutyramide seco-pseudonucleosides: new versatile homochiral synthons for synthesis of modified oligonucleotides.
PubMed:Norepinephrine induces slow calcium signalling in murine brown preadipocytes through the beta-adrenoceptor/cAMP/protein kinase A pathway.
PubMed:Synthesis and activity of a metabolite of (S)-6-amino-5-(6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxamido)-3-methyl-1-phenyl-2,4-(1H,3H)-pyrimidinedione (CX-659S).
PubMed:New C(19)-diterpenoid alkaloids from the roots of Delphinium potaninii var. jiufengshanense.
PubMed:The influence of ligand side chain on the enantioselectivity of Lewis acid catalyzed Diels-Alder reactions.
PubMed:Preparation of chiral 4-benzyloxymethyldihydrofuran-2-one using lipase-catalyzed kinetic resolution: synthesis of (-)-virginiae butanolide C (VB C).
PubMed:Synthesis and anticonvulsant activity of some omega-(1H-1-imidazolyl)-N-phenylalkanoic acid amide derivatives.
PubMed:Synthesis of new tricyclic melatoninergic ligands.
PubMed:Triethylenetetramine-N,N,N',N",N"',N"'-hexaacetic Acid (TTHA) and TTHA-Bis(butanamide) as Chelating Agents Relevant to Radiopharmaceutical Applications.
PubMed:X-Ray Photoelectron Spectroscopy Analysis of Di-(2-ethylhexyl) Phosphoric Acid Activated Membranes.
PubMed:Synthesis of N4-(2-acetamido-2-deoxy-beta-D-glucopyranosyl)-L-asparagine analogues. n-Butyramide, 3-chloropropionamide, 3-aminopropionamide, and isovaleramide analogues.
PubMed:Potential clinical use of butyric acid derivatives to induce antigen-specific T cell inactivation.
PubMed:Steric hindrance regulation of the Pseudomonas aeruginosa amidase operon.
PubMed:Structural adaptation to selective pressure for altered ligand specificity in the Pseudomonas aeruginosa amide receptor, amiC.
PubMed:Competitive lipase-catalyzed ester hydrolysis and ammoniolysis in organic solvents; equilibrium model of a solid-liquid-vapor system.
PubMed:Synthesis and analgesic activity of N-aryl/arylalkyl 3-(1-pyrrolidinyl/piperidinyl)butyramides.
PubMed:Synthesis and characterization of a photoactivatable glycoaryldiazirine for surface glycoengineering.
PubMed:Inhibition of R-[3H]-baclofen binding to rat brain synaptic membranes by a homologous series of phenyl alcohol amides anticonvulsants and their evaluation as GABAB receptor blockers.
PubMed:Synthesis of a new homologous series of p-chlorophenyl alcohol amides, their anticonvulsant activity and their testing as potential GABAB receptor antagonists.
PubMed:Photochemical protease: site-specific photocleavage of hen egg lysozyme and bovine serum albumin.
PubMed:Acyl transfer activity of an amidase from Rhodococcus sp. strain R312: formation of a wide range of hydroxamic acids.
PubMed:Analogues of the potential antipsychotic agent 1192U90: amide modifications.
PubMed:Modification of nitric oxide synthase activity and neuronal response in rat striatum by melatonin and kynurenine derivatives.
PubMed:Effect of butyrate analogues on proliferation and differentiation in human neuroblastoma cell lines.
PubMed:Synthesis and pharmacological evaluation of a new homologous series of (+/-)-p-fluoro-phenyl alcohol amide anticonvulsants.
PubMed:Modulation of rat striatal glutamatergic response in search for new neuroprotective agents: evaluation of melatonin and some kynurenine derivatives.
PubMed:Synthesis and intravenous infusion into the rat of glyceryl bisacetoacetate, 1-acetoacetamido-2, 3-propane diol, and partially reduced glucosyl pentaacetoacetate.
PubMed:Oligomerization of the amide sensor protein AmiC by x-ray and neutron scattering and molecular modeling.
PubMed:Side Chain Entropy and the Activation of Organocobalamins for Carbon-Cobalt Bond Homolysis: Synthesis, Characterization, and Thermolysis of the Neopentyl Derivative of a Unique Cobalamin Analog Lacking a c Side Chain.
PubMed:Design, synthesis, cytotoxic properties and preliminary DNA sequencing evaluation of CPI--N-methylpyrrole hybrids. Enhancing effect of a trans double bond linker and role of the terminal amide functionality on cytotoxic potency.
PubMed:Inhibition of matrix metalloproteinases by hydroxamates containing heteroatom-based modifications of the P1' group.
PubMed:Hypoxia-selective antitumor agents. 10. bis(nitroimidazoles) and related Bis(nitroheterocycles): development of derivatives with higher rates of metabolic activation under hypoxia and improved aqueous solubility.
PubMed:Dicarboxylic acid dipeptide neutral endopeptidase inhibitors.
PubMed:Discordant effects of butyrate analogues on erythroleukemia cell proliferation, differentiation and histone deacetylase.
PubMed:Desensitization of beta-adrenergic responses in adipocytes involves receptor subtypes and cAMP phosphodiesterase.
PubMed:Synthesis and histamine H2-receptor antagonist activity of 4-(1-pyrazolyl)butanamides, guanidinopyrazoles, and related compounds.
PubMed:Evidence for an excited-state reaction contributing to NADH fluorescence.
PubMed:N-[2-(2-methyl-5-nitroimidazolyl)ethyl]-4-(2-nitroimidazolyl)butanamide (NSC 639862), a bisnitroimidazole with enhanced selectivity as a bioreductive drug.
PubMed:Crystal structure of AmiC: the controller of transcription antitermination in the amidase operon of Pseudomonas aeruginosa.
PubMed:Purification and characterization of an amidase from an acrylamide-degrading Rhodococcus sp.
PubMed:Determinants of apical membrane permeabilities of barrier epithelia.
PubMed:Anti-atherosclerotic and plasma lipid lowering effects of the novel calcium blocker with alpha 1-adrenoceptor antagonistic activity, monatepil, in high cholesterol diet-fed Japanese Macaca fuscata monkeys.
PubMed:Effect of GABA analogues on various components of maximum electroshock-induced seizures in mice.
PubMed:Hypoxia-selective antitumor agents. 8. Bis(nitroimidazolyl)alkanecarboxamides: a new class of hypoxia-selective cytotoxins and hypoxic cell radiosensitisers.
PubMed:Butyramide and monobutyrin: growth inhibitory and differentiating agents.
PubMed:Structure of the complex between trypanosomal triosephosphate isomerase and N-hydroxy-4-phosphono-butanamide: binding at the active site despite an "open" flexible loop conformation.
PubMed:Neuropharmacology of amide derivatives of P-GABA.
PubMed:[Allosterism of acidic alcohol dehydrogenase (class III ADH) of mouse liver and its role in alcohol metabolism].
PubMed:Metabolism of benzonitrile and butyronitrile by Klebsiella pneumoniae.
PubMed:Antiulcer agents. II. Synthesis and gastric acid antisecretory activity of N-[3-(3-(piperidinomethyl)phenoxy)propyl]-4-(1-methyl-1H- tetrazol-5-ylthio)butanamide and related compounds.
PubMed:Dual effect of the local anaesthetic penticainide on the Na+ current of guinea-pig ventricular myocytes.
PubMed:On the use of T61 for euthanasia of domestic and laboratory animals; an ethical evaluation.
PubMed:[The use of T61 for the humane killing of pets and laboratory animals].
PubMed:Ascaris lumbricoides: detecting its metabolites in the urine of infected people using gas-liquid chromatography.
PubMed:Degradation of Acetonitrile by Pseudomonas putida.
PubMed:Properties of the block of single Na+ channels in guinea-pig ventricular myocytes by the local anaesthetic penticainide.
PubMed:Inhibitors of cyclic AMP phosphodiesterase. 4. Synthesis and evaluation of potential prodrugs of lixazinone (N-cyclohexyl-N-methyl-4-[(1,2,3,5-tetrahydro-2- oxoimidazo[2,1-b]quinazolin-7-yl)-oxy]butyramide, RS-82856).
PubMed:Comparative studies on the dependence liability of morphine hydrochloride, codeine phosphate and two novel antitussive compounds vadocaine hydrochloride and N-(2',4'-dimethyl-6'-methoxyphenyl)-4-(diethylamine) butanamide hydrochloride in mice.
PubMed:An experiment in enzyme evolution. Studies with Pseudomonas aeruginosa amidase.
PubMed:Antisecretory and antiulcer activities of a potent new histamine H2-receptor antagonist with an intermediate duration of action.
PubMed:14C-labeling of bromobutide, 2-bromo-3,3-dimethyl-N-(alpha, alpha-dimethylbenzyl)butyramide.
PubMed:Electrochemical evaluation of the interaction between ascorbic acid and the cardiotonic drug RS-82856.
PubMed:Inhibitors of cyclic AMP phosphodiesterase. 2. Structural variations of N-cyclohexyl-N-methyl-4-[(1,2,3,5-tetrahydro- 2-oxoimidazo[2,1-b]quinazolin-7-yl)-oxy]butyramide (RS-82856).
PubMed:Human platelet osmotic water and nonelectrolyte transport.
PubMed:Purification and characterization of N,N-dimethylformamidase from Pseudomonas DMF 3/3.
PubMed:A potent and selective inhibitor of cyclic AMP phosphodiesterase with potential cardiotonic and antithrombotic properties.
PubMed:Photoaffinity labeling of the tetrabenazine binding sites of bovine chromaffin granule membranes.
PubMed:The metabolism of cilostamide in the rat in vitro and in vivo.
PubMed:Purification of cyclic adenosine monophosphate phosphodiesterase from human platelets using new-inhibitor Sepharose chromatography.
PubMed:[3-Benzyl-1,2-benzoisothiazoles: spasmolytic properties of the aminoalkyl derivatives].
PubMed:[Pharmacological actions of alkylaminoalkyl-phenylbenzisothazole compounds on the gastrointestinal tract].
PubMed:Measurement of progabide and its deaminated metabolite in plasma by high-performance liquid chromatography and electrochemical detection.
PubMed:Studies on 2-oxoquinoline derivatives as blood platelet aggregation inhibitors. III. N-cyclohexyl-N-(2-hydroxyethyl)-4-(1,2-dihydro-2-oxo-6-quinolyloxy)-butyramide and related compounds.
PubMed:[Studies on absorption, biotransformation and excretion of drug. VIII. Metabolic fate of a new analgesic and anti-inflammatory agent, 2-oxo-3-[4-(1-oxo-2-isoindolinyl)phenyl]-butanamide (OIB) in rats].
PubMed:Evidence that SL75102 is an agonist at GABAb as well as GABAa receptors.
PubMed:gamma-Aminobutyric acid (GABA) receptor stimulation. I. Neuropharmacological profiles of progabide (SL 76002) and SL 75102, with emphasis on their anticonvulsant spectra.
PubMed:Pharmacological investigation of gamma-aminobutyric acid (GABA) and fully-developed generalized seizures in the amygdala-kindled rat.
PubMed:Dissociation between behavioral and electrocortical manifestations of electroshock convulsions during the action of an anticonvulsive drug.
PubMed:Studies on an anti-inflammatory agent. III. Pharmacological investigations of a new non-steroidal anti-inflammatory agent: 2-oxo-3-[4-(1-oxo-2-isoindolinyl)-phenyl]-butanamide (GP 650).
PubMed:[Biopharmaceutical studies of drug. IV. Studies on the improvement of dissolution properties and gastrointestinal absorption of 2-oxo-3-[4-(1-oxo-2-isoindolinyl)phenyl]butanamide (author's transl)].
PubMed:113Cd NMR in binary and ternary complexes of cadmium-substituted horse liver alcohol dehydrogenase.
PubMed:Relation of ADH effects to altered membrane fluidity in toad urinary bladder.
PubMed:Cryoprotective effects of some amides on rabbit spermatozoa.
PubMed:New anticonvulsants: Schiff bases of gamma-aminobutyric acid and gamma-aminobutyramide.
PubMed:Molecular basis of altered enzyme specificities in a family of mutant amidases from Pseudomonas aeruginosa.
PubMed:Metabolites of loperamide in rats.
PubMed:Neurophysiological and neurochemical studies on the action of the anticonvulsant gamma-hydroxy, gamma-ethyl, gamma-phenyl-butyramide.
PubMed:Free radicals in U.V.-irradiated aqueous solutions of substituted amides: an e.s.r. and spin-trapping study.
PubMed:Loperamide in patients with radiotherapy-induced diarrhoea.
PubMed:Loperamide: a review of its pharmacological properties and therapeutic efficacy in diarrhoea.
PubMed:Experimental antiulcer drugs. 1. Indole-1-alkanamides and pyrrole-1-alkanamides.
PubMed:[Structure of bromine containing metabolites of carbromal (author's transl)].
PubMed:Nature of the water permeability increase induced by antidiuretic hormone (ADH) in toad urinary bladder and related tissues.
PubMed:Water and nonelectrolyte permeability of lipid bilayer membranes.
PubMed:Permeability of dog lung endothelium to sodium, diols, amides, and water.
PubMed:[Disopyramide phosphate: electrophysiological and inotropic effects in isolated cat papillary muscles and comparison with quinidine (author's transl)].
PubMed:Catabolite repression of Pseudomonas aeruginosa amidase: isolation of promotor mutants.
PubMed:The membrane action of antidiuretic hormone (ADH) on toad urinary bladder.
PubMed:Compounds related to 4-disopropylamino-2-phenyl-2(2-pyridyl)butyramide. Their synthesis and antiarrhythmic activity.
PubMed:Central anticholinergic activity of: 2,2-diphenyl-4(3-azabicyclo (3-2-2) non-3-yl) butyramide hydrochloride (SC-13639).
PubMed:3-amino-4-hydroxy-L(-)-butyramide hydrochloride.
PubMed:The effect of 2:2-diphenyl-4-N-hexamethylenimino-butyramide methiodide on experimental chronic ulcer in glandular stomach of rats.
PubMed:Mutations in a regulator gene allowing Pseudomonas aeruginosa 8602 to grow on butyramide.
PubMed:Butyramide-utilizing mutants of Pseudomonas aeruginosa 8602 which produce an amidase with altered substrate specificity.
PubMed:Studies on analgesics of aniline series. 3. Preparation and properties of N,N-dialkyl 3-(substituted anilino)butyramide series.
PubMed:Failure of beta-benzal butyramide, a recently reported hypocholesteremic agent, to reduce serum cholesterol in hypercholesteremic and normocholesteremic patients.
PubMed:RADIOGRAPHIC EVIDENCE FOR THE INHIBITION OF GASTRO-INTESTINAL MOTILITY BY R 658 (2,2 DIPHENYL-4-HEXAMETHYLENEIMINO-BUTYRAMIDE).
PubMed:Pharmacology of a new antiarrhythmic agent, gamma-diisopropyl-amino-alpha-phenyl-alpha-(2-pyridyl)-butyramide (SC-7031).
PubMed:[On the spasmodicity of Oddi's sphincter seen during duodenal intubation. Effects of the intraduodenal instillation of 2,2-diphenyl-4-(diisopropylamino)-butyramide methiodide].
PubMed:[Effects of 2,2-diphenyl-4-(diisopropylamino) butyramide methiodide on the peristaltic wave].
PubMed:[A new mydriatic, 2,2-diphenyl-2-hexamethylene-imino-butyramide hydrochloride (R-658)].
PubMed:Phenyl butyramide and the serum cholesterol concentration in man.
PubMed:The inhibition of basal gastric secretion and of the gastric secretory response to histamine by 2:2-diphenyl-4-diisopropylamino-butyramide methyliodide in man.
PubMed:[Medical treatment of gastroduodenal ulcer with 2, 2-diphenyl-4-(diisopropylamino)butyramide methiodide (R 79)].
PubMed:Antispasmodic properties of certain quaternary derivatives of 2,2-diphenyl-4-diisopropylamino-butyramide and other compounds in the isolated perfused guinea-pig lung.
PubMed:Substituted phenylpropylamines. III. Anticholinergic activity of quaternary ammonium bases derived from R 55 (2, 2-diphenyl-4-diisopropylamino-butyramide).
PubMed:The synthesis of potential antimalarials; derivatives of alpha, gamma-dihydroxy-beta, beta-dimethyl-N-ethylbutyramide.
 
Notes:
Butyramide is the amide of butyric acid. It has the molecular formula C3H7CONH2. It is a clear liquid that is highly soluble in water and ethanol, but slightly soluble in diethyl ether. At room temperature, butyramide is a crystalline solid. (Wikipedia)
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