EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

2-methyl-3-,5 or 6-(furfuryl thio) pyrazine
2-methyl-3-, 5- or 6-(furfurylthio)pyrazine

Sponsors

Name:2-[(furan-2-ylmethyl)sulfanyl]-5-methylpyrazine
CAS Number: 65530-53-2Picture of molecule3D/inchi
Nikkaji Web:J208.520H
CoE Number:2287
XlogP:1.30 (est)
Molecular Weight:206.26790000
Formula:C10 H10 N2 O S
NMR Predictor:Predict (works with chrome or firefox)
EFSA/JECFA Comments:
According to JECFA: Min. assay value is "99" and "Mixture of isomers: 70% 2,3-; 29% 2,6-; trace 2,5-".
Category:flavor and fragrance agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
JECFA Food Flavoring:1082 2-methyl-3-, 5- or 6-(furfurylthio)pyrazine
FLAVIS Number:13.151 (Old)
DG SANTE Food Flavourings:13.151 2-methyl-3,5 and 6-(furfurylthio)pyrazine
FEMA Number:3189 2-methyl-3-, 5- or 6-(furfurylthio)pyrazine
FDA:No longer provide for the use of these seven synthetic flavoring substances
 
Physical Properties:
Assay: 99.00 to 100.00 sum of isomers
Food Chemicals Codex Listed: No
Specific Gravity:1.13800 to 1.14800 @ 20.00 °C.
Pounds per Gallon - (est).: 9.480 to 9.564
Refractive Index:1.58000 to 1.58600 @ 20.00 °C.
Boiling Point: 153.00 to 156.00 °C. @ 10.00 mm Hg
Flash Point: 134.00 °F. TCC ( 56.67 °C. )
logP (o/w): 1.970
Soluble in:
 alcohol
 water, 198.1 mg/L @ 25 °C (est)
Insoluble in:
 water
 
Organoleptic Properties:
Odor Type: coffee
Odor Strength:high ,
recommend smelling in a 0.10 % solution or less
sulfurous nutty coffee roasted coffee cooked meaty
Odor Description:at 0.10 % in dipropylene glycol. sulfurous nutty roasted coffee cooked meat
Odor and/or flavor descriptions from others (if found).
Apiscent Labs
2 FURFURYLTHIO-(3 or 5)-METHYLPYRAZINE (2-Methyl-3-(furfurylthio)pyrazine)
Odor Description:Coffee and sesame seed oil
 
Cosmetic Information:
None found
 
Suppliers:
Advanced Biotech
2 FURFURYLTHIO 3(5/6)METHYL PYRAZINE
Anhui Suzhou Jinli Aromatic Chemicals
2-Furfurylthio-(3 or 5)-methyl pyrazine
Odor: coffee, Fried Sesame
Apiscent Labs
2 FURFURYLTHIO-(3 or 5)-METHYLPYRAZINE (2-Methyl-3-(furfurylthio)pyrazine)
Odor: Coffee and sesame seed oil
Beijing Lys Chemicals
2-Methyl-3(5/6)(furfurylthio)pyrazine
Charkit Chemical
METHYL-3(5/6)FURFURYLTHIO) PYRAZINE, 2- FEMA 3189
FCI SAS
2-FURFURYLTHIO-(3 or 5)-METHYL PYRAZINE
Odor: Roasted coffee, gingili
Fleurchem
2-methyl (3-furfuryl-thio) pyrazine
Jiangyin Healthway
2-Furfurylthio-3(5/6)-methyl pyrazine
New functional food ingredients
Jinan Enlighten Chemical Technology(Wutong Aroma )
2-methyl-3(5or6)-Furfurylthio pyrazine, Kosherk
M&U International
2-FURFURYLTHIO-3(5/6)-METHYL PYRAZINE, Kosher
Penta International
2-METHYL-3,5,6-(FURFURYLTHIO)PYRAZINE, Kosher
Reincke & Fichtner
2-Methyl-3-,5 Or 6-(furfurylthio)pyrazine (mixture Of Isomers)
Sigma-Aldrich
2-Methyl-3(5 or 6)-furfurylthiopyrazine, 97%
Certified Food Grade Products
Sunaux International
2-Furfurylthio-3(5/6)-methyl Pyrazine
Synerzine
2-Methyl-3,5 or 6-(Furfurylthio)-Pyrazine
Taytonn
2-Methyl-3(5/6)(Furfurylthio)
Odor: Coffee, Nutty, Roast
Tengzhou Jitian Aroma Chemiclal
2-Furfurylthio-3(5/6)-methyl pyrazine
Tengzhou Xiang Yuan Aroma Chemicals
2-Furfuralthio-3-(5/6)-Methyl Pyrazine
 
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
Xn - Harmful.
R 10 - Flammable.
R 22 - Harmful if swallowed.
R 36/38 - Irritating to skin and eyes.
S 02 - Keep out of the reach of children.
S 16 - Keep away from sources of ignition - No Smoking.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: flavor and fragrance agents
Recommendation for 2-methyl-3-,5 or 6-(furfuryl thio) pyrazine usage levels up to:
  0.0300 % in the fragrance concentrate.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 0.37 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 0.70 (μg/capita/day)
NOEL (No Observed Effect Level): 1.70 (mg/kg bw per day)
Structure Class: III
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 4
 average usual ppmaverage maximum ppm
baked goods: -1.00000
beverages(nonalcoholic): -1.00000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: -1.00000
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: -1.00000
fruit ices: -1.00000
gelatins / puddings: --
granulated sugar: --
gravies: -1.00000
hard candy: --
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --
 
Safety References:
European Food Safety Athority(efsa):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Scientific Opinion on Flavouring Group Evaluation 13Rev1: Furfuryl and furan derivatives with and without additional side-chain substituents and heteroatoms from chemical group 14
View page or View pdf

Consideration of sulfur-substituted furan derivatives used as flavouring agents evaluated by JECFA (59th meeting) structurally related to a subgroup of substances within the group of “Furfuryl and furan derivatives with and without additional side-chain substituents and heteroatoms from chemical group 14” evaluated by EFSA in FGE.13Rev1 (2009)
View page or View pdf

Flavouring Group Evaluation 67 (FGE.67): Consideration of 40 furan-substituted aliphatic hydrocarbons, alcohols, aldehydes, ketones, carboxylic acids and related esters, sulfides, disulfides and ethers evaluated by JECFA at the 65th meeting (JECFA, 2006b) and re-evaluated at the 69th meeting (JECFA, 2009c)
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 13, Revision 2 (FGE.13Rev2): Furfuryl and furan derivatives with and without additional side-chain substituents and heteroatoms from chemical group 14
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 67, Revision 1 (FGE.67Rev.1): Consideration of 40 furan-substituted aliphatic hydrocarbons, alcohols, aldehydes, ketones, carboxylic acids and related esters, sulfides, disulfides and ethers evaluated by JECFA at the 65th meeting (JECFA, 2006b) and re-evaluated at the 69th meeting (JECFA, 2009c)
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 65, Revision 1 (FGE.65Rev1): Consideration of sulfur-substituted furan derivatives used as flavouring agents evaluated by JECFA (59th meeting) structurally related to a subgroup of substances within the group of ‘Furfuryl and furan derivatives with and without additional side-chain substituents and heteroatoms from chemical group 14’ evaluated by EFSA in FGE.13Rev2 (2011)
View page or View pdf

EPI System: View
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :101003
National Institute of Allergy and Infectious Diseases:Data
WISER:UN 1993
WGK Germany:3
2-[(furan-2-ylmethyl)sulfanyl]-5-methylpyrazine
Chemidplus:0059035982
 
References:
 2-[(furan-2-ylmethyl)sulfanyl]-5-methylpyrazine
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):101003
Pubchem (sid):135020127
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):Search
FooDB:FDB009854
ChemSpider:View
EFSA Update of results on the monitoring of furan levels in food:Read Report
EFSA Previous report: Results on the monitoring of furan levels in food:Read Report
EFSA Report of the CONTAM Panel on provisional findings on furan in food:Read Report
 
Potential Blenders and core components note
For Odor
alliaceous
dimethyl trisulfide
FL/FR
methyl furfuryl disulfide
FL/FR
balsamic
2-
acetyl furan
FL/FR
caramellic
caramel furanone solution
FL/FR
coffee dione
FL/FR
cyclotene
FL/FR
fenugreek oleoresin
FL/FR
5-
methyl furfural
FL/FR
chocolate
2,6-
dimethyl pyrazine
FL/FR
2-
methyl butyraldehyde
FL/FR
2,4,5-
trimethyl thiazole
FL/FR
coffee
cappuccino fragrance
FR
cichorium intybus root extract
FL/FR
cichorium intybus root solid extract
FL/FR
coffea arabica fruit extract
FR
roasted
coffea arabica seed extract
FL/FR
coffea arabica seed extract
FL/FR
coffea arabica seed oil
FL/FR
coffee absolute
FL/FR
arabica
coffee bean butter
FL/FR
roasted arabica
coffee bean essence
FL/FR
roasted
coffee bean extract
FL/FR
roasted arabica
coffee bean oil
FL/FR
roasted arabica
coffee bean oil CO2 extract
FL/FR
coffee bean oil extract
FL/FR
coffee difuran
FL/FR
coffee fragrance
FR
coffee resinoid
FL/FR
furfuryl mercaptan
FL/FR
1-
hydroxy-2-butanone
FL/FR
earthy
nutty pyrazine
FL/FR
fruity
tropical thiazole
FL/FR
herbal
wormwood oil america
FL/FR
wormwood oil italy
FL/FR
wormwood oil poland
FL/FR
medicinal
2,6-
xylenol
FL/FR
moldy
strawberry furanone methyl ether
FL/FR
musty
menthofuran
FL/FR
nutty
3,5-
cocoa pyrazine
FL/FR
3,6-
cocoa pyrazine
FL/FR
2,3-
dimethyl pyrazine
FL/FR
4,5-
dimethyl-2-ethyl-3-thiazoline
FL/FR
2-
ethyl pyrazine
FL/FR
2-
ethyl-4-methyl thiazole
FL/FR
filbert heptenone
FL/FR
filbert heptenone B
FL/FR
5-
methyl quinoxaline
FL/FR
2-
methyl-3-(methyl thio) pyrazine
FL/FR
sesame absolute
FL/FR
sesame absolute CO2 extract
FL/FR
phenolic
para-alpha-
dimethyl styrene
FL/FR
popcorn
2-
acetyl pyrazine
FL/FR
roasted
fenugreek resinoid
FL/FR
trigonella foenum-graecum seed oil CO2 extract
FL/FR
sulfurous
benzothiazole
FL/FR
furfuryl thioacetate
FL/FR
S-
furfuryl thioformate
FL/FR
2-
mercaptopropionic acid
FL/FR
2-
methyl 5-(methyl thio) furan
FL/FR
3-
thiohexanol
FL/FR
sweet
2-
hydroxy-3,4,5-trimethyl-2-cyclopenten-1-one
FL/FR
vegetable
1-
furfuryl pyrrole
FL/FR
woody
juniper berry oleoresin
FL/FR
For Flavor
No flavor group found for these
2-
acetyl-6-methyl pyrazine
FL
1,2-
butane dithiol
FL
dimethyl dihydrocyclopentapyrazine
FL
(Z+E)-2,5-
dimethyl-3-tetrahydrofuran thiol
FL
(Z+E)-2,5-
dimethyl-3-thioacetoxytetrahydrofuran
FL
2,5-
dimethyl-3-thiofuroyl furan
FL
3-(
ethyl thio) butanol
FL
2-
ethyl-3-methyl thiopyrazine
FL
(Z+E)-5-
ethyl-4-methyl-2-(2-butyl) thiazoline
FL
(Z+E)-5-
ethyl-4-methyl-2-(2-methyl propyl) thiazoline
FL
2-
formyl pyrrole
FL
2-
hydroxy-3,4,5-trimethyl-2-cyclopenten-1-one
FL/FR
3-
mercapto-3-methyl butyl formate
FL
4-
mercapto-3-methyl-2-butanol
FL
methyl dihydrofuran thiol
FL
2-
methyl thiazolidine
FL
2-
methyl-3-(methyl thio) pyrazine
FL/FR
3-((2-
methyl-3-furyl)thio)-4-heptanone
FL
1,9-
nonane dithiol
FL
pyrazines mixture
FL
3-
thienyl mercaptan
FL
5-
acetyl-2,3-dihydro-1,4-thiazine
FL
3,7-
dimethyl-2,6-octadien-1-yl cyclopropyl carboxamide
FL
2-
methyl-1-methyl thio-2-butene
FL
pyrrolidino-(1,2E)-4H-2,4-dimethyl-1,3,5-dithiazine
FL
alliaceous
alliaceous
benzyl mercaptan
FL
dicyclohexyl disulfide
FL
dimethyl trisulfide
FL/FR
tropical thiazole
FL/FR
brown
fenugreek oleoresin
FL/FR
1-
hydroxy-2-butanone
FL/FR
5-
methyl furfural
FL/FR
burnt
furfuryl alcohol
FL
2-
methyl quinoxaline
FL
2,6-
xylenol
FL/FR
caramellic
caramel furanone solution
FL/FR
cyclotene
FL/FR
fenugreek resinoid
FL/FR
coffee
cichorium intybus root extract
FL/FR
cichorium intybus root solid extract
FL/FR
coffea arabica seed extract
FL/FR
roasted
coffea arabica seed extract
FL/FR
coffea arabica seed oil
FL/FR
coffee absolute
FL/FR
arabica
coffee bean butter
FL/FR
roasted arabica
coffee bean essence
FL/FR
roasted
coffee bean extract
FL/FR
roasted arabica
coffee bean oil CO2 extract
FL/FR
coffee bean oil extract
FL/FR
coffee difuran
FL/FR
coffee dione
FL/FR
coffee distillates
FL
coffee pyrazine
FL
coffee resinoid
FL/FR
difurfuryl ether
FL
diisoamyl thiomalate
FL
2,4-
dimethyl thiazole
FL
2-
ethyl-4-methyl thiazole
FL/FR
furfuryl mercaptan
FL/FR
methyl furfuryl disulfide
FL/FR
methyl furfuryl thiol
FL
2-
thiophene thiol
FL
earthy
difurfuryl sulfide
FL
fruity
furfuryl isobutyrate
FL
furfuryl isovalerate
FL
furfuryl propionate
FL
fusel
2-
methyl butyraldehyde
FL/FR
green
2-
methyl-5-isopropyl pyrazine
FL
herbal
wormwood oil america
FL/FR
wormwood oil italy
FL/FR
wormwood oil poland
FL/FR
meaty
benzothiazole
FL/FR
2,6-
dimethyl thiophenol
FL
1,1-
ethane dithiol 1% in ethanol 94.5% / ethyl acetate 4%
FL
3-
mercapto-2-butanone
FL
(R,S)-2-
mercapto-3-butanol
FL
2-
mercaptopropionic acid
FL/FR
2-
methyl 3-(methyl thio) furan
FL
12-
methyl tridecanal
FL
bis(2-
methyl-3-furyl) disulfide
FL
S-(2-
methyl-3-furyl) ethane thioate
FL
propyl 2-mercaptopropionate
FL
pyrazinyl ethane thiol
FL
2-
pyridinyl methane thiol
FL
thialdine
FL
molasses
molasses blackstrap
FL
moldy
strawberry furanone methyl ether
FL/FR
mustard
furfuryl methyl ether
FL
musty
2-
ethoxythiazole
FL
menthofuran
FL/FR
2-
methyl 5-(methyl thio) furan
FL/FR
nutty
2-
acetyl furan
FL/FR
2-
acetyl-4-methyl thiazole
FL
2-
butyl-2-butenal
FL
3,6-
cocoa pyrazine
FL/FR
3,5-
cocoa pyrazine
FL/FR
2,6-
dimethyl pyrazine
FL/FR
2,3-
dimethyl pyrazine
FL/FR
4,5-
dimethyl-2-ethyl-3-thiazoline
FL/FR
2-
ethyl pyrazine
FL/FR
1-
ethyl-2-acetyl pyrrole
FL
filbert heptenone
FL/FR
filbert heptenone B
FL/FR
5-
methyl quinoxaline
FL/FR
nutty pyrazine
FL/FR
nutty thiazole
FL
sesame absolute
FL/FR
sesame absolute CO2 extract
FL/FR
2,4,5-
trimethyl thiazole
FL/FR
onion
furfuryl isopropyl sulfide
FL
popcorn
2-
propionyl-2-thiazoline
FL
roasted
2-
acetyl pyrazine
FL/FR
roasted arabica
coffee bean oil
FL/FR
ethyl 3-(furfuryl thio) propionate
FL
furfuryl thioacetate
FL/FR
trigonella foenum-graecum seed oil CO2 extract
FL/FR
solvent
2-
ethyl furan
FL
spicy
para-alpha-
dimethyl styrene
FL/FR
sulfurous
2,3-
butane dithiol
FL
butyl mercaptan
FL
ethyl methyl sulfide
FL
S-
ethyl thioacetate
FL
S-
furfuryl thioformate
FL/FR
furfuryl thiopropionate
FL
3-
methyl-2-butane thiol
FL
roasted butanol
FL
2-
thienyl mercaptan
FL
3-
thiohexanol
FL/FR
vegetable
1-
furfuryl pyrrole
FL/FR
woody
juniper berry oleoresin
FL/FR
 
Potential Uses:
FRchocolate
FRcoffee
FLmeat
FLnut roasted nut
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
2-[(furan-2-ylmethyl)sulfanyl]-5-methylpyrazine
2-(furan-2-ylmethylsulfanyl)-3-methylpyrazine
((2-furanylmethyl)thio)methylpyrazine
2-furfuryl thio-3(5/6)methyl pyrazine
2-furfuryl thio-5-methyl pyrazine
2-furfuryl thio-6-methyl pyrazine
2-furfurylthio 3(5/6)methyl pyrazine
2 furfurylthio-(3 or 5)-methylpyrazine (2-methyl-3-(furfurylthio)pyrazine)
2-furfurylthio-3-methylpyrazine
2-furfurylthio-3(5/6)-methyl pyrazine
2-furfurylthio-5-methylpyrazine
2-furfurylthio-6-methylpyrazine
2-methyl-3 or 5 or 6-(furfurylthio)pyrazine (mixture of isomers)
2-methyl-3-, 5- or 6-(furfurylthio)pyrazine
2-methyl-3-,5 or 6-(furfurylthio) pyrazine
2-methyl-3-(furfurylthio)pyrazine
2-methyl-3,5 and 6-(furfurylthio)pyrazine
2-methyl-3,5 or 6-(furfurylthio)-pyrazine
2-methyl-3,5 or 6-(furfurylthio)pyrazine
2-methyl-3,5,6-(furfurylthio)pyrazine
2-methyl-3(5/6)(furfurylthio)
2-methyl-3(or 5 or 6)-(furfurylthio)pyrazine
 pyrazine, ((2-furanylmethyl)thio)methyl-
 pyrazine, 2-((2-furanylmethyl)thio)-3-methyl-
 

Articles:

 None found yet.
 
Notes:
None found
Please share your Comments.
Email Address:
Top of Page Home
Copyright © 1980-2018 The Good Scents Company (tgsc) ™ Disclaimer Privacy Policy