EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

difurfuryl sulfide
2,2'-(thiodimethylene)difuran

Sponsors

Name:2-(furan-2-ylmethylsulfanylmethyl)furan
CAS Number: 13678-67-6Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:237-172-3
FDA UNII:X6O686CPCO
Nikkaji Web:J277.984F
MDL:MFCD00010081
CoE Number:11438
XlogP3-AA:2.10 (est)
Molecular Weight:194.25310000
Formula:C10 H10 O2 S
NMR Predictor:Predict (works with chrome or firefox)
Category:flavoring agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
JECFA Food Flavoring:1080 2,2'-(thiodimethylene)difuran
FLAVIS Number:13.056 (Old)
DG SANTE Food Flavourings:13.056 difurfuryl sulfide
FEMA Number:3238 2,2'-(thiodimethylene)difuran
FDA:No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm: 2,2'-(THIODIMETHYLENE)-DIFURAN
 
Physical Properties:
Appearance:yellow brown to brown solid (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:1.14400 to 1.15400 @ 25.00 °C.
Pounds per Gallon - (est).: 9.519 to 9.602
Refractive Index:1.54500 to 1.56000 @ 20.00 °C.
Melting Point: 29.00 to 32.00 °C. @ 760.00 mm Hg
Boiling Point: 130.00 to 131.00 °C. @ 9.00 mm Hg
Boiling Point: 135.00 to 143.00 °C. @ 14.00 mm Hg
Vapor Pressure:0.012000 mm/Hg @ 25.00 °C. (est)
Vapor Density:6.6 ( Air = 1 )
Flash Point:> 230.00 °F. TCC ( > 110.00 °C. )
logP (o/w): 1.365 (est)
Soluble in:
 alcohol
 water, 110.9 mg/L @ 25 °C (est)
Insoluble in:
 water
Stability:
 stable at room temp
 
Organoleptic Properties:
Odor Type: earthy
Odor Strength:high ,
recommend smelling in a 0.10 % solution or less
earthy mushroom coffee meaty sulfurous
Odor Description:at 0.10 % in propylene glycol. powerful earthy mushroom coffee meaty sulfury
earthy fungal mushroom meaty roasted meaty cocoa coffee nutty
Odor Description:at 0.10 % in propylene glycol. Mild, earthy, fungal, mushroom-like with roasted meaty undertone, cocoa and coffee with nutty nuances
Mosciano, Gerard P&F 26, No. 5, 68, (2001)
Flavor Type: earthy
earthy mushroom metallic bloody savory
Taste Description: at 0.10 - 0.30 ppm. Earthy, mushroom, metallic, with bloody savory notes
Mosciano, Gerard P&F 26, No. 5, 68, (2001)
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Advanced Biotech
DIFURFURYL SULFIDE NATURAL
98% min.
Odor: Meaty
Advanced Biotech
DIFURFURYL SULFIDE
Anhui Haibei
Difurfuryl Sulphide
Odor: Nut odor, stir-fry coffee
Anhui Suzhou Jinli Aromatic Chemicals
Difurfuryl Sulfide
Odor: nut, roast coffee
Aurochemicals
DIFURFURYL SULFIDE 1% IN ETOH, Natural
Aurochemicals
DIFURFURYL SULFIDE 1% IN PG, Natural
Aurochemicals
DIFURFURYL SULFIDE, Natural
Beijing Lys Chemicals
2,2'-(Thiodimethylene) difuran
BOC Sciences
For experimental / research use only.
Difurfurylsulfide
Carbosynth
For experimental / research use only.
Difurfuryl monosulphide
Charkit Chemical
THIODIMETHYLENE)DIFURAN, 2,2-( T0400 FEMA 3238
DeLong Chemicals America
2,2'-(Thiodimethylene) difuran, Kosher
Jinan Enlighten Chemical Technology(Wutong Aroma )
Difurfuryl sulfide, Kosherk
M&U International
DIFURFURYL SULFIDE, Kosher
Penta International
2,2`-(THIODIMETHYLENE)DIFURAN, Kosher
Robinson Brothers
Difurfuryl monosulphide F&F
https://www.robinsonbrothers.uk/chemistry-competences
Sigma-Aldrich
2,2'-(Thiodimethylene)difuran, ≥98%
Odor: cheese; meaty; coffee; nutty; earthy; alliaceous (onion, garlic); vegetable.
Certified Food Grade Products
Sunaux International
Difurfuryl Sulfide
Synerzine
2,2'-(Thiodimethylene) Difuran
Taytonn
2,2-(Thiodimethylene)Difuran
Odor: Coffee, Meaty, Roast
TCI AMERICA
For experimental / research use only.
Difurfuryl Sulfide >98.0%(GC)
Tengzhou Jitian Aroma Chemiclal
Difurfuryl Sulfide
Tengzhou Xiang Yuan Aroma Chemicals
Difurfuryl Sulfide
Treatt
Difurfuryl monosulphide
Halal, Kosher
 
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
Xi - Irritant
R 36/37/38 - Irritating to eyes, respiratory system, and skin.
S 02 - Keep out of the reach of children.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: flavoring agents
Recommendation for difurfuryl sulfide usage levels up to:
 not for fragrance use.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 0.73 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 0.005 (μg/capita/day)
NOEL (No Observed Effect Level): 10.00 (mg/kg bw per day)
Structure Class: III
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 4
 average usual ppmaverage maximum ppm
baked goods: -1.00000
beverages(nonalcoholic): -1.00000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: -1.00000
condiments / relishes: -1.00000
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: -1.00000
fruit ices: -1.00000
gelatins / puddings: -1.00000
granulated sugar: --
gravies: -1.00000
hard candy: -1.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: -1.00000
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: -1.00000
sugar substitutes: --
sweet sauces: --
 
Safety References:
European Food Safety Athority(efsa):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Flavouring Group Evaluation 13 (FGE.13); Furfuryl and furan derivatives with and without additional side-chain substituents and heteroatoms from chemical group 14 (Commission Regulation (EC) No 1565/2000 of 18
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 13Rev1: Furfuryl and furan derivatives with and without additional side-chain substituents and heteroatoms from chemical group 14
View page or View pdf

Consideration of sulfur-substituted furan derivatives used as flavouring agents evaluated by JECFA (59th meeting) structurally related to a subgroup of substances within the group of “Furfuryl and furan derivatives with and without additional side-chain substituents and heteroatoms from chemical group 14” evaluated by EFSA in FGE.13Rev1 (2009)
View page or View pdf

Flavouring Group Evaluation 67 (FGE.67): Consideration of 40 furan-substituted aliphatic hydrocarbons, alcohols, aldehydes, ketones, carboxylic acids and related esters, sulfides, disulfides and ethers evaluated by JECFA at the 65th meeting (JECFA, 2006b) and re-evaluated at the 69th meeting (JECFA, 2009c)
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 13, Revision 2 (FGE.13Rev2): Furfuryl and furan derivatives with and without additional side-chain substituents and heteroatoms from chemical group 14
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 67, Revision 1 (FGE.67Rev.1): Consideration of 40 furan-substituted aliphatic hydrocarbons, alcohols, aldehydes, ketones, carboxylic acids and related esters, sulfides, disulfides and ethers evaluated by JECFA at the 65th meeting (JECFA, 2006b) and re-evaluated at the 69th meeting (JECFA, 2009c)
View page or View pdf

Statement on List of Representative Substances for Testing. The current Statement lays down a list of substances in sub-groups with representative substances for which additional data are required prior to their evaluation through the Procedure (Regulation (EC) No 1565/2000).
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 65, Revision 1 (FGE.65Rev1): Consideration of sulfur-substituted furan derivatives used as flavouring agents evaluated by JECFA (59th meeting) structurally related to a subgroup of substances within the group of ‘Furfuryl and furan derivatives with and without additional side-chain substituents and heteroatoms from chemical group 14’ evaluated by EFSA in FGE.13Rev2 (2011)
View page or View pdf

EPI System: View
EPA Substance Registry Services (TSCA):13678-67-6
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :61659
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
2-(furan-2-ylmethylsulfanylmethyl)furan
Chemidplus:0013678676
 
References:
 2-(furan-2-ylmethylsulfanylmethyl)furan
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:13678-67-6
Pubchem (cid):61659
Pubchem (sid):135017471
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS):View
HMDB (The Human Metabolome Database):HMDB41503
FooDB:FDB021475
Export Tariff Code:2932.19.1000
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
EFSA Update of results on the monitoring of furan levels in food:Read Report
EFSA Previous report: Results on the monitoring of furan levels in food:Read Report
EFSA Report of the CONTAM Panel on provisional findings on furan in food:Read Report
 
Potential Blenders and core components note
For Odor
chocolate
2,6-
dimethyl pyrazine
FL/FR
earthy
dibenzyl ether
FL/FR
methyl undecylenate
FL/FR
mushroom absolute
FL/FR
1-
nonen-3-ol
FL/FR
3-
octanol
FL/FR
1-
octen-3-ol
FL/FR
1-
octen-3-one
FL/FR
fatty
methyl 10-undecenoate
FL/FR
floral
octyl acetate
FL/FR
2-
phenyl propionaldehyde dimethyl acetal
FL/FR
2-
phenyl propionaldehyde ethylene glycol acetal
FR
fungal
1-
decen-3-ol
FL/FR
black
truffle whole plant oil
FL/FR
green
earthy acetal
FL/FR
(Z)-
leaf acetal
FL/FR
phenyl acetaldehyde dimethyl acetal
FL/FR
mushroom
(R)-1-
octen-3-ol
FL/FR
musty
menthofuran
FL/FR
sulfurous
fish thiol
FL/FR
4-
methyl 4-mercaptopentan-2-one 1% solution
FL/FR
woody
sclareolide
FL/FR
For Flavor
No flavor group found for these
earthy acetal
FL/FR
ethyl 4-(acetyl thio) butyrate
FL
4-
methyl 4-mercaptopentan-2-one 1% solution
FL/FR
tris(
methyl thio) methane
FL
2-
methyl-3-furyl tetrasulfide
FL
1,9-
nonane dithiol
FL
(E)-2-
penten-1-ol
FL
alliaceous
alliaceous
1,3-
butane dithiol
FL
earthy
1-
decen-3-ol
FL/FR
1-
hexen-3-yl acetate
FL
mushroom absolute
FL/FR
1-
nonen-3-ol
FL/FR
1,8-
octane dithiol
FL
1-
octen-3-one
FL/FR
fruity
dibenzyl ether
FL/FR
2-
phenyl propionaldehyde dimethyl acetal
FL/FR
fungal
black
truffle whole plant oil
FL/FR
green
(Z)-
leaf acetal
FL/FR
phenyl acetaldehyde dimethyl acetal
FL/FR
meaty
2,6-
dimethyl thiophenol
FL
2,5-
dimethyl-3-furan thiol
FL
3-
mercapto-2-butanone
FL
pyrazinyl ethane thiol
FL
metallic
2,5-
dihydroxy-1,4-dithiane
FL
mushroom
1-
octen-3-ol
FL/FR
(R)-1-
octen-3-ol
FL/FR
musty
menthofuran
FL/FR
3-
octanol
FL/FR
nutty
2,6-
dimethyl pyrazine
FL/FR
nutty thiazole
FL
roasted
hexyl mercaptan
FL
sulfurous
S-
ethyl thioacetate
FL
fish thiol
FL/FR
methyl 2-methyl-3-furyl disulfide
FL
waxy
methyl 10-undecenoate
FL/FR
methyl undecylenate
FL/FR
octyl 2-furoate
FL
octyl acetate
FL/FR
woody
sclareolide
FL/FR
 
Potential Uses:
FLbeef
FLchicken
 chocolate cocoa
FLcoffee
FLsavory
 
Occurrence (nature, food, other):note
 coffee
Search PMC Picture
 
Synonyms:
 difurfuryl monosulfide
 difurfuryl monosulphide
 difurfuryl sulfide natural
 difurfurylsulfide
2-(furan-2-ylmethylsulfanylmethyl)furan
 furan, 2,2'-(thiodimethylene)di-
 furan, 2,2'-[thiobis(methylene)]bis-
2-furfuryl monosulfide
 furfuryl sulfide
bis 2-furfuryl sulfide
bis(2-furfuryl) sulfide
2-furyl(2-furylmethylthio)methane
2,2'-[sulfanediylbis(methylene)]difuran
2,2'-(sulfanediyldimethanediyl)difuran
 sulfide, bis(2-furfuryl)
2,2'-(thiobis(methylene))bisfuran
2,2'-[thiobis(methylene)]bisfuran
2,2-(thiodimethylene) difuran
2,2'-(thiodimethylene) difuran
2,2-(thiodimethylene)-difuran
2,2-(thiodimethylene)difuran
2,2'-(thiodimethylene)difuran
 
 
Notes:
Present in coffee. Flavouring ingredient
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