EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

2-ethyl-3-methoxypyrazine
pyrazine, 2-methoxy-3-ethyl

Sponsors

Name:2-ethyl-3-methoxypyrazine
CAS Number: 25680-58-4Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:247-184-0
FDA UNII:ZBM5LD0WE9
Nikkaji Web:J208.493G
MDL:MFCD00006129
CoE Number:11329
XlogP3:1.80 (est)
Molecular Weight:138.16990000
Formula:C7 H10 N2 O
NMR Predictor:Predict (works with chrome or firefox)
Category:flavor and fragrance agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
FLAVIS Number:14.112 (Old)
DG SANTE Food Flavourings:14.112 2-ethyl-3-methoxypyrazine
 
Physical Properties:
Appearance:colorless clear liquid (est)
Assay: 99.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:1.04900 @ 25.00 °C.
Refractive Index:1.50200 @ 20.00 °C.
Boiling Point: 90.00 °C. @ 40.00 mm Hg
Boiling Point: 80.00 to 95.00 °C. @ 10.00 mm Hg
Vapor Pressure:1.577000 mm/Hg @ 25.00 °C. (est)
Flash Point: 156.00 °F. TCC ( 68.89 °C. )
logP (o/w): 1.800
Soluble in:
 alcohol
 water, 2474 mg/L @ 25 °C (est)
Insoluble in:
 water
 
Organoleptic Properties:
Odor Type: earthy
Odor Strength:high ,
recommend smelling in a 0.10 % solution or less
potato raw potato earthy green pepper bell pepper nutty
Odor Description:at 0.10 % in dipropylene glycol. raw potato earthy bell pepper nutty
Odor and/or flavor descriptions from others (if found).
Pell Wall Perfumes
Earthy Pyrazine
Odor Description:raw-potato, damp-soil, musty, natural, nutty, roasted
As with all pyrazines this is used in tiny traces Earthy Pyrazine at 0.1% in IPM smells rather like raw potato or freshly dug soil, but this material is also present in the scent of coffee and chocolate so it’s more versatile than might at first be thought. Even at this dilution this is a very strong scent that combines well with Geosmin, Terranol and similar materials to give a wet effect. Also with nutty, chocolatey and, perhaps surprisingly with green notes, to give warmth, depth and diffusion.
FCI SAS
2-METHOXY-3-ETHYL PYRAZINE
Odor Description:Earthy, pepper, clay
 
Cosmetic Information:
None found
 
Suppliers:
Apiscent Labs
2 METHOXY 3 ETHYL PYRAZINE
Odor: Earth, clay, pepper
Beijing Lys Chemicals
2-Ethyl-3-methoxypyrazine
BOC Sciences
For experimental / research use only.
2-Ethyl-3-methoxypyrazine
FCI SAS
2-METHOXY-3-ETHYL PYRAZINE
Odor: Earthy, pepper, clay
Frutarom
2-METHOXY-3-ETHYL PYRAZINE
Jinan Enlighten Chemical Technology(Wutong Aroma )
2-Ethyl-3-methoxy pyrazine, Kosherk
M&U International
2-METHOXY-3-ETHYL PYRAZINE, Kosher
Pell Wall Perfumes
Earthy Pyrazine
Odor: raw-potato, damp-soil, musty, natural, nutty, roasted
Use: As with all pyrazines this is used in tiny traces Earthy Pyrazine at 0.1% in IPM smells rather like raw potato or freshly dug soil, but this material is also present in the scent of coffee and chocolate so it’s more versatile than might at first be thought. Even at this dilution this is a very strong scent that combines well with Geosmin, Terranol and similar materials to give a wet effect. Also with nutty, chocolatey and, perhaps surprisingly with green notes, to give warmth, depth and diffusion.
Penta International
2-METHOXY-3-ETHYLPYRAZINE, Kosher
Phoenix Aromas & Essential Oils
Pyrazine, 2-Methoxy-3-Ethyl
Robinson Brothers
2-Ethyl-3-methoxypyrazine F&F
https://www.robinsonbrothers.uk/chemistry-competences
Sigma-Aldrich
2-Ethyl-3-methoxypyrazine, ≥99%, FG
Certified Food Grade Products
Sunaux International
2-Methoxy-3-ethyl Pyrazine
Synerzine
2-Methoxy-3-Ethylpyrazine
Tengzhou Jitian Aroma Chemiclal
2-Methoxy-3-ethyl pyrazine
Tengzhou Xiang Yuan Aroma Chemicals
2-Ethoxy-3-(5/6)-Methyl Pyrazine
Treatt
2-Ethyl-3-methoxypyrazine
Kosher
 
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
Xn - Harmful.
R 22 - Harmful if swallowed.
R 37/38 - Irritating to respiratory system and skin.
S 02 - Keep out of the reach of children.
S 20/21 - When using do not eat, drink or smoke.
S 23 - Do not breath vapour.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 39 - Wear eye/face protection.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: flavor and fragrance agents
Recommendation for 2-ethyl-3-methoxypyrazine usage levels up to:
  0.0200 % in the fragrance concentrate.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 0.17 (μg/capita/day)
Threshold of Concern:90 (μg/person/day)
Structure Class: III
 
Safety References:
European Food Safety Athority(efsa):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Scientific Opinion on Flavouring Group Evaluation 17, Revision 3 (FGE.17Rev3): Pyrazine derivatives from chemical group 24
View page or View pdf

Safety and efficacy of pyrazine derivatives including saturated ones belonging to chemical group 24 when used as flavourings for all animal species
View page or View pdf

EPI System: View
EPA Substance Registry Services (TSCA):25680-58-4
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :33135
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
2-ethyl-3-methoxypyrazine
Chemidplus:0025680584
 
References:
 2-ethyl-3-methoxypyrazine
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:25680-58-4
Pubchem (cid):33135
Pubchem (sid):134997249
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEMBL:View
HMDB (The Human Metabolome Database):HMDB40054
FooDB:FDB019741
Export Tariff Code:2933.99.8090
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
 
Potential Blenders and core components note
For Odor
balsamic
bornyl formate
FL/FR
chocolate
cocoa hexenal
FL/FR
citrus
(E)-2-
tetradecenal
FL/FR
coconut
delta-
heptalactone
FL/FR
earthy
1-
nonen-3-ol
FL/FR
nutty pyrazine
FL/FR
1-
octen-3-ol
FL/FR
floral
linalool oxide
FL/FR
octyl acetate
FL/FR
2-
phenyl propyl acetate
FL/FR
fruity
amyl formate
FL/FR
2-
pentyl furan
FL/FR
tropical trithiane
FL/FR
green
2-iso
butyl-3-methoxypyrazine
FL/FR
2-sec-
butyl-3-methoxypyrazine
FL/FR
cortex pyridine
FL/FR
galbanum decatriene
FL/FR
galbanum resinoid
FL/FR
geranium absolute
FL/FR
(Z)-3-
hexen-1-yl tiglate
FL/FR
(E,Z)-3,6-
nonadien-1-ol
FL/FR
1-
phenyl-2-pentanol
FL/FR
herbal
6-
hydroxydihydrotheaspirane (mixture of isomers)
FL/FR
marine
marine hexane
FR
musty
menthofuran
FL/FR
nutty
2-
acetyl-3-ethyl pyrazine
FL/FR
3,6-
cocoa pyrazine
FL/FR
2-
methyl thio-3,5 or 6-methyl pyrazine
FL/FR
shoyu pyrazine
FL/FR
vegetable
methional
FL/FR
waxy
octyl isobutyrate
FL/FR
For Flavor
No flavor group found for these
benzyl disulfide
FL
bornyl formate
FL/FR
dimethyl dihydrocyclopentapyrazine
FL
green pea pyrazine
FL
2-
methoxy-3-propyl pyrazine
FL
methyl 2-(methyl thio) acetate
FL
4-(
methyl thio) butanol
FL
2-
pentyl pyridine
FL
2-
phenyl propyl acetate
FL/FR
alliaceous
alliaceous
3-
mercapto-2-pentanone
FL
2-
methyl thioacetaldehyde
FL
camphoreous
6-
hydroxydihydrotheaspirane (mixture of isomers)
FL/FR
cocoa
cocoa hexenal
FL/FR
creamy
octyl isobutyrate
FL/FR
earthy
1-
nonen-3-ol
FL/FR
fruity
amyl formate
FL/FR
1-
phenyl-2-pentanol
FL/FR
tropical trithiane
FL/FR
green
2-iso
butyl-3-methoxypyrazine
FL/FR
cortex pyridine
FL/FR
galbanum decatriene
FL/FR
galbanum resinoid
FL/FR
geranium absolute
FL/FR
(Z)-3-
hexen-1-yl tiglate
FL/FR
linalool oxide
FL/FR
(E,Z)-3,6-
nonadien-1-ol
FL/FR
2-
pentyl furan
FL/FR
propylene glycol acetone ketal
FL
lactonic
delta-
heptalactone
FL/FR
milky
dextro,laevo-3-(
methyl thio) butanone
FL
mushroom
1-
octen-3-ol
FL/FR
musty
menthofuran
FL/FR
shoyu pyrazine
FL/FR
nutty
2-
acetyl-3-ethyl pyrazine
FL/FR
3,6-
cocoa pyrazine
FL/FR
2-
ethyl-6-methyl pyrazine
FL
2-
methyl thio-3,5 or 6-methyl pyrazine
FL/FR
nutty pyrazine
FL/FR
sulfurous
potato butanone
FL
tomato
methional
FL/FR
vegetable
2-sec-
butyl-3-methoxypyrazine
FL/FR
potato butyraldehyde
FL
waxy
octyl acetate
FL/FR
(E)-2-
tetradecenal
FL/FR
winey
5-
ethyl-2-methyl pyridine
FL
 
Potential Uses:
FRcoffee
FRearth
FLnut
FLpepper bell pepper
FLpotato
 
Occurrence (nature, food, other):note
 grape
Search Trop Picture
 potato
Search Trop Picture
 wine
Search Picture
 
Synonyms:
 earthy pyrazine
2-ethyl-3-methoxy pyrazine
2-ethyl-3-methoxy-pyrazine
2 methoxy 3 ethyl pyrazine
2-methoxy-3-ethyl pyrazine
2-methoxy-3-ethylpyrazine
 pyrazine, 2-ethyl-3-methoxy-
 pyrazine, 2-methoxy-3-ethyl
 

Articles:

 None found yet.
 
Notes:
Constit. of potato and wine must. Flavour enhancer for dehydrated potato. Component of *FEMA 3280*
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