EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

2-isopropyl pyrazine
2-isopropylpyrazine

Supplier Sponsors

Name:2-propan-2-ylpyrazine
CAS Number: 29460-90-0Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:249-646-7
FDA UNII: 14XE115G58
Nikkaji Web:J250.852D
MDL:MFCD00060871
CoE Number:11343
XlogP3:1.00 (est)
Molecular Weight:122.17070000
Formula:C7 H10 N2
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:flavoring agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
JECFA Food Flavoring:764 2-isopropylpyrazine
DG SANTE Food Flavourings:14.123 isopropylpyrazine
FEMA Number:3940 2-isopropylpyrazine
FDA:No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF):29460-90-0 ; 2-ISOPROPYLPYRAZINE
 
Physical Properties:
Appearance:colorless to pale yellow clear liquid (est)
Assay: 98.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:0.96700 to 0.97200 @ 25.00 °C.
Pounds per Gallon - (est).: 8.046 to 8.088
Refractive Index:1.48600 to 1.49600 @ 20.00 °C.
Boiling Point: 70.00 °C. @ 20.00 mm Hg
Boiling Point: 169.00 to 170.00 °C. @ 760.00 mm Hg
Vapor Pressure:2.008000 mmHg @ 25.00 °C. (est)
Flash Point: 144.00 °F. TCC ( 62.22 °C. )
logP (o/w): 1.281 (est)
Soluble in:
 alcohol
 water
 water, 6327 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor Type: minty
minty green nutty honey
Odor Description:at 0.10 % in dipropylene glycol. minty green nutty honey
Flavor Type: coffee
coffee caramellic fruity
Taste Description: coffee caramellic fruity
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
2-isoPropylpyrazine
Jiangyin Healthway
2-isopropyl pyrazine
New functional food ingredients
Parchem
isopropyl pyrazine
Penta International
2-ISOPROPYL PYRAZINE
Santa Cruz Biotechnology
For experimental / research use only.
2-isoPropylpyrazine
Sigma-Aldrich: Aldrich
For experimental / research use only.
2-isoPropylpyrazine
Synerzine
2-isopropylpyrazine
Tengzhou Jitian Aroma Chemiclal
2-isoPropyl Pyrazine
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
flavoring agents
Recommendation for 2-isopropyl pyrazine usage levels up to:
 not for fragrance use.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 0.12 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 0.10 (μg/capita/day)
Structure Class: II
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 19
Click here to view publication 19
 average usual ppmaverage maximum ppm
baked goods: 1.000002.00000
beverages(nonalcoholic): 0.500001.00000
beverages(alcoholic): 0.500001.00000
breakfast cereal: 1.000002.00000
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: 0.500001.00000
fruit ices: --
gelatins / puddings: 0.500001.00000
granulated sugar: --
gravies: --
hard candy: --
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: 0.500001.00000
soups: --
sugar substitutes: --
sweet sauces: --
 
Safety References:
European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the Commission related to Flavouring Group Evaluation 17 (FGE.17): Pyrazine derivatives from chemical group 24 (Commission Regulation (EC) No 1565/2000 of 18 July 2000)
View page or View pdf

Flavouring Group Evaluation 50 (FGE.50): Consideration of pyrazine derivatives evaluated by JECFA (57th meeting) structurally related to pyrazine derivatives evaluated by EFSA in FGE.17 (2005) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf

Flavouring Group Evaluation 17, Revision 1 (FGE.17Rev1): Pyrazine derivatives from chemical group 24 - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) [1]
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 17, Revision 2 (FGE.17Rev2): Pyrazine derivatives from chemical group 24
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 50, Revision 1 (FGE.50Rev1): Consideration of pyrazine derivatives evaluated by JECFA (57th meeting) structurally related to pyrazine derivatives evaluated by EFSA in FGE.17Rev2 (2010)
View page or View pdf

EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):29460-90-0
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :34590
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
2-propan-2-ylpyrazine
Chemidplus:0029460900
 
References:
 2-propan-2-ylpyrazine
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:29460-90-0
Pubchem (cid):34590
Pubchem (sid):134998039
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
HMDB (The Human Metabolome Database):HMDB41570
FooDB:FDB021560
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
 
Potential Blenders and core components note
For Odor
buttery
iso
butyl lactate
FL/FR
caramellic
fenugreek absolute
FL/FR
maltyl propionate
FL/FR
rosefuran
FL/FR
strawberry furanone
FL/FR
citrus
ocimene quintoxide
FL/FR
ethereal
acetal
FL/FR
fermented
ethyl crotonate
FL/FR
floral
geranium oil china
FL/FR
ortho-
methyl acetophenone
FL/FR
fruity
2-
cyclopentyl cyclopentanone
FL/FR
green
2-tert-
butyl pyrazine
FL/FR
herbal
apium graveolens seed extract
FL/FR
barosma betulina leaf oil
FL/FR
dehydroxylinalool oxide
FL/FR
melaleuca leucadendron cajaputi oil
FL/FR
licorice
sweet
basil oleoresin
FL/FR
minty
agathosma crenulata leaf oil
FL/FR
ethyl salicylate
FL/FR
methyl salicylate
FL/FR
peppermint absolute
FL/FR
iso
propyl tiglate
FL/FR
iso
pulegyl formate
FL/FR
spearmint absolute
FL/FR
spearmint oil america
FL/FR
nutty
3,5-
cocoa pyrazine
FL/FR
2,3-
dimethyl pyrazine
FL/FR
2-
ethyl-4-methyl thiazole
FL/FR
2-
methyl pyrazine
FL/FR
shoyu pyrazine
FL/FR
spicy
origanum majorana oil
FL/FR
sulfurous
buchu mercaptan
FL/FR
For Flavor
No flavor group found for these
2-tert-
butyl pyrazine
FL/FR
2-
cyclopentyl cyclopentanone
FL/FR
2,5-
diethyl-4-methyl thiazole
FL
ethyl 2-methyl-2-(methyl thio) propionate
FL
iso
pulegyl formate
FL/FR
rosefuran
FL/FR
anisic
anisic
ortho-
methyl acetophenone
FL/FR
buttery
iso
butyl lactate
FL/FR
caramellic
5-
ethyl-3,4,5,6-tetramethyl cyclohexen-2-one
FL
fenugreek absolute
FL/FR
fenugreek distillates
FL
maltyl propionate
FL/FR
strawberry furanone
FL/FR
coffee
2-
ethyl-4-methyl thiazole
FL/FR
dairy
creme brulle coffee flavor
FL
floral
geranium oil china
FL/FR
green
4-
methyl thiazole
FL
ocimene quintoxide
FL/FR
iso
propyl tiglate
FL/FR
herbal
apium graveolens seed extract
FL/FR
barosma betulina leaf oil
FL/FR
melaleuca leucadendron cajaputi oil
FL/FR
origanum majorana oil
FL/FR
licorice
sweet
basil oleoresin
FL/FR
minty
agathosma crenulata leaf oil
FL/FR
ethyl salicylate
FL/FR
methyl salicylate
FL/FR
peppermint absolute
FL/FR
spearmint absolute
FL/FR
spearmint oil america
FL/FR
musty
shoyu pyrazine
FL/FR
nutty
acetal
FL/FR
3,5-
cocoa pyrazine
FL/FR
2,3-
dimethyl pyrazine
FL/FR
2-
methyl pyrazine
FL/FR
rummy
ethyl crotonate
FL/FR
sulfurous
buchu mercaptan
FL/FR
woody
dehydroxylinalool oxide
FL/FR
 
Potential Uses:
FLgreen
FLherbal
FRlavender
FLmint
FLpeppermint
 
Occurrence (nature, food, other):note
 crab meat
Search PMC Picture
 fish sauce
Search PMC Picture
 
Synonyms:
(1-methyl ethyl) pyrazine
(1-methylethyl)pyrazine
2-(methylethyl)pyrazine
2-(propan-2-yl)pyrazine
2-propan-2-ylpyrazine
isopropyl pyrazine
2-isopropyl-1,4-diazine
2-isopropylprazine
2-isopropylpyrazine
isopropylpyrazine
 pyrazine, (1-methylethyl)-
 pyrazine, 2-(1-methylethyl)-
 
 
Notes:
Flavouring ingredient
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