EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

3,5(6)-cocoa pyrazine
ethyl-(3,5 or 6)-methoxypyrazine (85%) and 2-methyl-(3,5 or 6)-methoxypyrazine (13%)

Sponsors

Flavor Demo Formulas
Name:2-ethyl-3,5-dimethylpyrazine; 3-ethyl-2,5-dimethylpyrazine
CAS Number: 55031-15-7Picture of molecule3D/inchi
FDA UNII:1D80F4PE6E
MDL:MFCD00047392
CoE Number:727
Molecular Weight:272.39528000
Formula:C16 H24 N4
NMR Predictor:Predict (works with chrome or firefox)
Also(can) Contains:3,6-cocoa pyrazine
 3,5-cocoa pyrazine
EFSA/JECFA Comments:
JECFA evaluated 2-ethyl-3 (5 or 6)-dimethylpyrazine (CASrn 13360-65-1, 13925-07-0). Mixture of positional isomers (2-Ethyl-3,5/6-dimethyl-), 2-ethyl-3,5-dimethylpyrazine (50-57 %); 2-ethyl-3,6-dimethylpyrazine (43-50 %) (EFFA, 2010a). JECFA CASrn: (13360-65-1, 13925-07-0).
Category:flavoring agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
JECFA Food Flavoring:789 ethyl-(3,5 or 6)-methoxypyrazine (85%) and 2-methyl-(3,5 or 6)-methoxypyrazine (13%)
FLAVIS Number:14.100 (Old)
DG SANTE Food Flavourings:14.100 3,(5- or 6)-dimethyl-2-ethylpyrazine
FEMA Number:3149 ethyl-(3,5 or 6)-methoxypyrazine (85%) and 2-methyl-(3,5 or 6)-methoxypyrazine (13%)
FDA:No longer provide for the use of these seven synthetic flavoring substances
 
Physical Properties:
Appearance:colorless to pale yellow clear liquid (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:0.96500 @ 25.00 °C.
Melting Point: 64.00 to 66.00 °C. @ 8.00 mm Hg
Boiling Point: 180.00 to 182.00 °C. @ 760.00 mm Hg
Vapor Density:4.6 ( Air = 1 )
Flash Point: 157.00 °F. TCC ( 69.44 °C. )
Soluble in:
 water
Stability:
 stable in most media
 
Organoleptic Properties:
Odor Type: nutty
Odor Strength:high ,
recommend smelling in a 1.00 % solution or less
Substantivity:5 hour(s) at 100.00 %
nutty nut skin hazelnut peanut chocolate roasted
Odor Description:at 1.00 % in dipropylene glycol. nutty nut skin hazelnut peanut chocolate roasted
Luebke, William tgsc, (2009)
Odor sample from: Apiscent Labs, LLC
nut skin brown sweet musty peanut roasted peanut
Odor Description:Nut skin, brown, sweet, musty, with a slightly roasted peanut shell nuance
Mosciano, Gerard P&F 17, No. 3, 57, (1992)
Flavor Type: nutty
peanut nut skin brown hazelnut roasted hazelnut coffee chocolate
Taste Description: at 5.00 ppm. Peanut, nut skin, brown, roasted, hazelnut, with coffee and chocolate nuances
Mosciano, Gerard P&F 17, No. 3, 57, (1992)
Odor and/or flavor descriptions from others (if found).
Sigma-Aldrich
2-Ethyl-3(5 or 6)-dimethylpyrazine, mixture of isomers, ≥95%, FG
Odor Description:almond; beef; caramel; cheese; corn; coffee; earthy; woody; tobacco.
Taste Description:peanut nut skin brown roasted hazelnut coffee chocolate
Treatt
2-Ethyl-3(5/6)-dimethylpyrazine Halal, Kosher
Odor Description:roast nuts/almonds, cocoa/coffee, woody/potato crisps
Pell Wall Perfumes
Cocoa Pyrazine
Odor Description:chocolate, cocoa, nutty-hazelnut and peanut, roasted
As with all pyrazines this is used in traces Cocoa Pyrazine at 0.1% in PG has a distinctively chocolate and cocoa powder odour with elements of roasted nuts. Occurs in various nuts, asparagus, tea and tobacco as well as chocolate. Even at 0.1% this is a very powerful material that can easily dominate your blend, so use with caution.
 
Cosmetic Information:
None found
 
Suppliers:
Ambles Nature et Chimie
2-ETHYL-3(5or6)-DIMETHYL PYRAZINE
Apiscent Labs
2 ETHYL-3(5 or 6) DIMETHYLPYRAZINE
Odor: Chocolate, coffee, nut
BOC Sciences
For experimental / research use only.
2-Ethyl-3,5-dimethylpyrazine 98%
Charkit Chemical
COCOA PYRAZINE 10% IN PG
Charkit Chemical
DIMETHYL ETHYL PYRAZINE NATURAL FEMA 3149
Charkit Chemical
ETHYL-3(5/6)-DIMETHYLPYRAZINE, 2- FEMA 3149
Endeavour Specialty Chemicals
2-Ethyl-3,5(6)-dimethylpyrazine 99% F&F
Speciality Chemical Product Groups
Ernesto Ventós
2-ETHYL-3(5 OR 6)-DIMETHYLPYRAZINE
Odor: NUTTY, EARTHY, WOODY
FCI SAS
2-ETHYL-3, 5(6)-DIMETHYL PYRAZINE
Odor: Chocolate, coffee, nut
Indukern F&F
2-ETHYL-3,5(6)-DIMETHYL PYRAZINE
Odor: POTATO, CACAO, NUTTY, TOASTED
Lluch Essence
PYRAZINE 2-ETHYL-3,5(6)-DIMETHYL
M&U International
2-ETHYL-3(5/6)-DIMETHYLPYRAZINE, Kosher
Myrazine
2-Ethyl-3,5 (or 6)-dimethyl pyrazine/EU Nat.
Pell Wall Perfumes
Cocoa Pyrazine 1%
Odor: chocolate, cocoa, nutty-hazelnut and peanut, roasted
Use: As with all pyrazines this is used in traces Cocoa Pyrazine at 1% in Ethanol has a strong, distinctively chocolate and cocoa powder odour with elements of roasted nuts.
Pell Wall Perfumes
Cocoa Pyrazine
Odor: chocolate, cocoa, nutty-hazelnut and peanut, roasted
Use: As with all pyrazines this is used in traces Cocoa Pyrazine at 0.1% in PG has a distinctively chocolate and cocoa powder odour with elements of roasted nuts. Occurs in various nuts, asparagus, tea and tobacco as well as chocolate. Even at 0.1% this is a very powerful material that can easily dominate your blend, so use with caution.
Phoenix Aromas & Essential Oils
Pyrazine, 2-Ethyl-3, 5(6)-Dimethyl
Reincke & Fichtner
2-Ethyl-3,(5 or 6)-dimethylpyrazine
Sigma-Aldrich
2-Ethyl-3(5 or 6)-dimethylpyrazine, mixture of isomers, ≥95%, FG
Odor: almond; beef; caramel; cheese; corn; coffee; earthy; woody; tobacco.
Certified Food Grade Products
Sunaux International
2-Ethyl-3(5/6)-dimethyl Pyrazine
Synerzine
coco pyrazines mixture in P.G.
Treatt
2-Ethyl-3(5/6)-dimethylpyrazine
Halal, Kosher
Odor: roast nuts/almonds, cocoa/coffee, woody/potato crisps
Treatt
Cocoa Pyrazine 10% In Pg
Halal, Kosher
 
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
Xn - Harmful.
R 22 - Harmful if swallowed.
R 36/37/38 - Irritating to eyes, respiratory system, and skin.
S 02 - Keep out of the reach of children.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
gavage-rat LD50 456 mg/kg
(Moran et al., 1980)

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: flavoring agents
Recommendation for 3,5(6)-cocoa pyrazine usage levels up to:
 not for fragrance use.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 38.00 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 9.00 (μg/capita/day)
Structure Class: II
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 4
 average usual ppmaverage maximum ppm
baked goods: -5.00000
beverages(nonalcoholic): -5.00000
beverages(alcoholic): --
breakfast cereal: -2.00000
cheese: --
chewing gum: --
condiments / relishes: -2.00000
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: --
fruit ices: --
gelatins / puddings: -2.00000
granulated sugar: --
gravies: -2.00000
hard candy: -5.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: -2.00000
milk products: -1.00000
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --
 
Safety References:
European Food Safety Athority(efsa):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the Commission related to Flavouring Group Evaluation 17 (FGE.17): Pyrazine derivatives from chemical group 24 (Commission Regulation (EC) No 1565/2000 of 18 July 2000)
View page or View pdf

Flavouring Group Evaluation 50 (FGE.50): Consideration of pyrazine derivatives evaluated by JECFA (57th meeting) structurally related to pyrazine derivatives evaluated by EFSA in FGE.17 (2005) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf

Flavouring Group Evaluation 17, Revision 1 (FGE.17Rev1): Pyrazine derivatives from chemical group 24 - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) [1]
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 17, Revision 2 (FGE.17Rev2): Pyrazine derivatives from chemical group 24
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 50, Revision 1 (FGE.50Rev1): Consideration of pyrazine derivatives evaluated by JECFA (57th meeting) structurally related to pyrazine derivatives evaluated by EFSA in FGE.17Rev2 (2010)
View page or View pdf

Safety and efficacy of pyrazine derivatives including saturated ones belonging to chemical group 24 when used as flavourings for all animal species
View page or View pdf

EPA Substance Registry Services (TSCA):55031-15-7
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :16220104
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
2-ethyl-3,5-dimethylpyrazine; 3-ethyl-2,5-dimethylpyrazine
Chemidplus:0027043056
 
References:
 2-ethyl-3,5-dimethylpyrazine; 3-ethyl-2,5-dimethylpyrazine
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:55031-15-7
Pubchem (cid):16220104
Pubchem (sid):103183513
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):Search
FooDB:FDB009405
Export Tariff Code:2933.99.9700
VCF-Online:VCF Volatile Compounds in Food
 
Potential Blenders and core components note
For Odor
No odor group found for these
sulfuryl octanoate
FL/FR
sulfuryl butyrate
FL/FR
sulfuryl decanoate
FL/FR
sulfuryl hexanoate
FL/FR
sulfuryl isobutyrate
FL/FR
sulfuryl propionate
FL/FR
balsamic
balsamic
propyl benzoate
FL/FR
caramellic
ethyl 2-hydroxy-2-methyl butyrate
FL/FR
chocolate
chocolate pyrazine A
FL/FR
2-
methoxy-3-methyl pyrazine
FL/FR
2-
methyl butyraldehyde
FL/FR
earthy
2-
ethyl-3-methoxypyrazine
FL/FR
fermented
valeraldehyde
FL/FR
green
2-
heptyl furan
FL/FR
(E,Z)-2,6-
nonadien-1-yl acetate
FL/FR
naphthyl
para-
methyl anisole
FL/FR
nutty
2-
acetyl-3,5-dimethyl pyrazine
FL/FR
3,6-
cocoa pyrazine
FL/FR
filbert heptenone
FL/FR
2-
methyl pyrazine
FL/FR
2-
methyl-3-propyl pyrazine
FL/FR
2,4,5-
trimethyl oxazole
FL/FR
popcorn
2-
acetyl thiazole
FL/FR
tobacco
3-
ethyl pyridine
FL/FR
For Flavor
No flavor group found for these
butyramide
FL
chocolate pyrazine A
FL/FR
chocolate pyrazine B
FL
cyclohexyl methyl pyrazine
FL
2,5-
diethyl thiazole
FL
2,5-
diethyl-4-methyl thiazole
FL
6,7-
dihydro-2,3-dimethyl-5H-cyclopentapyrazine
FL
2,5-
dimethyl thiazole
FL
ethyl 2-hydroxy-2-methyl butyrate
FL/FR
2-
ethyl-3-methoxypyrazine
FL/FR
methyl 2-(methyl thio) acetate
FL
2-
propyl pyridine
FL
para-
salicylic acid
FL
sulfuryl butyrate
FL/FR
sulfuryl decanoate
FL/FR
sulfuryl hexanoate
FL/FR
sulfuryl isobutyrate
FL/FR
sulfuryl octanoate
FL/FR
sulfuryl propionate
FL/FR
bitter
bitter
methyl ethoxypyrazine
FL
brown
juglans nigra hulls extract
FL
juglans nigra shell extract
FL
burnt
2,4,5-
trimethyl oxazole
FL/FR
caramellic
3-
ethyl pyridine
FL/FR
coffee
difurfuryl ether
FL
2-iso
propyl pyrazine
FL
corn chip
2-
acetyl thiazole
FL/FR
2-
acetyl-2-thiazoline
FL
earthy
2-
methyl-3-propyl pyrazine
FL/FR
fatty
2-
heptyl furan
FL/FR
fruity
propyl benzoate
FL/FR
fusel
2-
methyl butyraldehyde
FL/FR
green
dihydroxyacetophenone (mixed isomers)
FL
2-
methyl-5-isopropyl pyrazine
FL
(E,Z)-2,6-
nonadien-1-yl acetate
FL/FR
2-
vinyl pyrazine
FL
naphthyl
para-
methyl anisole
FL/FR
nutty
2-
acetyl-3,5-dimethyl pyrazine
FL/FR
3,6-
cocoa pyrazine
FL/FR
1-
ethyl-2-acetyl pyrrole
FL
2-
ethyl-6-methyl pyrazine
FL
filbert heptenone
FL/FR
2-
methoxy-3-methyl pyrazine
FL/FR
2-
methyl pyrazine
FL/FR
roasted
acer spicatum bark extract
FL
gluconyl ethanolamine
FL
lactoyl ethanolamine phosphate
FL
spicy
cinnamon hazelnut cappuccino flavor
FL
winey
valeraldehyde
FL/FR
 
Potential Uses:
FLalmond
 burnt
FLcaramel
 chocolate cocoa
FLcoffee
FLhazelnut
FLmeat
FLpeanut
FLpopcorn
FLpotato
FLroasted
FLrum
FLwalnut
FLwhiskey
FRwoody
 
Occurrence (nature, food, other):note
 asparagus
Search Trop Picture
 cocoa
Search Trop Picture
 coffee
Search PMC Picture
 filbert
Search Trop Picture
 meat
Search PMC Picture
 peanut
Search Trop Picture
 popcorn
Search PMC Picture
 potato baked potato
Search Trop Picture
 rum
Search PMC Picture
 shrimp
Search PMC Picture
 soy products
Search PMC Picture
 tea
Search Trop Picture
 tobacco burley tobacco
Search Picture
 tobacco virginia tobacco
Search Picture
 whiskey
Search Picture
 
Synonyms:
3,5(6)-dimethyl-2-ethyl pyrazine mixture
3,(5- or 6)-dimethyl-2-ethylpyrazine
3,5(6)-dimethyl-2-ethylpyrazine mixture
 ethyl dimethyl pyrazine natural
 ethyl-(3,5 or 6)-methoxypyrazine (85%) and 2-methyl-(3,5 or 6)-methoxypyrazine (13%)
 ethyl-3,(5 or 6)-dimethyl pyrazine
 ethyl-3,(5 or 6)-dimethylpyrazine
2-ethyl-3,(5 or 6)-dimethylpyrazine
2-ethyl-3,5-dimethylpyrazine; 3-ethyl-2,5-dimethylpyrazine
2-ethyl-3,5(6)-dimethyl pyrazine
2-ethyl-3,5(6)-dimethyl pyrazine mixture
2-ethyl-3,5(6)-dimethylpyrazine
2-ethyl-3,5(6)-dimethylpyrazine mixture
2-ethyl-3,5{6}-dimethyl pyrazine
2 ethyl-3(5 or 6) dimethylpyrazine
2-ethyl-3(5 or 6)-dimethylpyrazine
2-ethyl-3(5/6)-dimethylpyrazine
 pyrazine, 2-ethyl-3, 5(6)-dimethyl
 

Articles:

 None found yet.
 
Notes:
Used as a food additive [EAFUS]
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