EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

nutty quinoxaline
5,6,7,8-tetrahydroquinoxaline

Supplier Sponsors

Name:5,6,7,8-tetrahydroquinoxaline
CAS Number: 34413-35-9Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:252-002-8
FDA UNII:M153CJ9RA0
Nikkaji Web:J250.881H
MDL:MFCD00038078
CoE Number:721
XlogP3-AA:0.90 (est)
Molecular Weight:134.18170000
Formula:C8 H10 N2
NMR Predictor:Predict (works with chrome or firefox)
Category:flavor and fragrance agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
JECFA Food Flavoring:952 5,6,7,8-tetrahydroquinoxaline
FLAVIS Number:14.015 (Old)
DG SANTE Food Flavourings:14.015 5,6,7,8-tetrahydroquinoxaline
FEMA Number:3321 5,6,7,8-tetrahydroquinoxaline
FDA:No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF):34413-35-9 ; 5,6,7,8-TETRAHYDROQUINOXALINE
 
Physical Properties:
Appearance:colorless to amber clear solid (est)
Assay: 98.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:1.07700 to 1.08700 @ 25.00 °C.
Pounds per Gallon - (est).: 8.962 to 9.045
Refractive Index:1.53800 to 1.54800 @ 20.00 °C.
Melting Point: 29.00 to 30.00 °C. @ 760.00 mm Hg
Boiling Point: 108.00 to 111.00 °C. @ 760.00 mm Hg
Boiling Point: 85.00 °C. @ 3.00 mm Hg
Vapor Pressure:0.055000 mmHg @ 25.00 °C. (est)
Vapor Density:4.6 ( Air = 1 )
Flash Point: 195.00 °F. TCC ( 90.56 °C. )
logP (o/w): 1.158 (est)
Shelf Life: 12.00 month(s) or longer if stored properly.
Storage:refrigerate in tightly sealed containers.
Soluble in:
 alcohol
 water, slightly
 water, 2091 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor Type: nutty
Odor Strength:high ,
recommend smelling in a 0.10 % solution or less
musty nutty roasted beany cereal corn chip cheesy
Odor Description:at 0.10 % in dipropylene glycol. musty nut roasted bean cereal corn chip cheese
musty nutty roasted beany cereal
Odor Description:Musty, nutty, roasted, beany, cereal cracker-like, with corn nuances
Mosciano, Gerard P&F 19, No. 2, 55, (1994)
Flavor Type: nutty
nutty musty corn taco popcorn
Taste Description: at 10.00 ppm. Nutty, musty, corn taco and popcorn-like
Mosciano, Gerard P&F 19, No. 2, 55, (1994)
Odor and/or flavor descriptions from others (if found).
R C Treatt & Co Ltd
5,6,7,8-Tetrahydroquinoxaline Halal, Kosher
Odor Description:Fatty/cheesy
Taste Description:nutty, roasted, cereal
Frutarom
5,6,7,8-TETRAHYDROQUINOXALINE
Odor Description:Bean, Musty, Nutty, Roast
Suggested Uses: Bakery, Cheese, Chocolate, Cocoa, Nut, Vanilla
OQEMA
5,6,7,8-Tetrahydro Quinoxaline
Odor Description:Fatty/cheesy
Taste Description:nutty, roasted, cereal
 
Cosmetic Information:
None found
 
Suppliers:
Advanced Biotech
5,6,7,8 TETRAHYDROQUINOXALINE
Ambles Nature et Chimie
5.6.7.8-TETRAHYDROQUINOXALINE
Anhui Haibei
5,6,7,8-Tetrahydroquinoxaline
Odor: Musty nut roasted bean cereal cracker corn cheese
Anhui Suzhou Jinli Aromatic Chemicals
5,6,7,8-Tetrahydro quinoxaline
Odor: baked hazel nut, baked peanut
Beijing Lys Chemicals
5,6,7,8-Tetrahydroquinoxaline
BOC Sciences
For experimental / research use only.
5.6.7.8-Tetrahydroquinoxaline
Charkit Chemical
TETRAHYDROQUINOXALINE,5,6,7,8- FEMA 3321
De Monchy Aromatics
5,6,7,8-Tetrahydroquinoxaline
DeLong Chemicals America
5,6,7,8-Tetrahydroquinoxaline, Kosher
Endeavour Specialty Chemicals
5,6,7,8-Tetrahydroquinoxaline
Speciality Chemical Product Groups
FCI SAS
TETRAHYDROQUINOXALINE
Odor: Roasted peanut
Fleurchem
5,6,7,8-tetrahydroquinoxaline
Frutarom
5,6,7,8-TETRAHYDROQUINOXALINE
Odor: Bean, Musty, Nutty, Roast
Use: Suggested Uses: Bakery, Cheese, Chocolate, Cocoa, Nut, Vanilla
Indukern F&F
TETRAHYDROQUINOXALINE
Odor: CHEESE, NUTTY, CEREAL
Jiangyin Healthway
5,6,7,8-Tetrahydroquinoxaline
New functional food ingredients
Jinan Enlighten Chemical Technology(Wutong Aroma )
5,6,7,8-Tetrahydro quinoxaline, Kosherk
M&U International
5,6,7,8-TETRAHYDROQUINOXALINE, Kosher
OQEMA
5,6,7,8-Tetrahydro Quinoxaline
Penta International
5,6,7,8-TETRAHYDROQUINOXALINE
R C Treatt & Co Ltd
5,6,7,8-Tetrahydroquinoxaline
Halal, Kosher
Odor: Fatty/cheesy
Flavor: nutty, roasted, cereal
Robinson Brothers
5,6,7,8-Tetrahydroquinoxaline F&F
https://www.robinsonbrothers.uk/chemistry-competences
Santa Cruz Biotechnology
For experimental / research use only.
5,6,7,8-Tetrahydroquinoxaline
Sigma-Aldrich
5,6,7,8-Tetrahydroquinoxaline, ≥97%, FG
Odor: cheese
Certified Food Grade Products
Sunaux International
5,6,7,8-Tetrahydroquinoxaline
Synerzine
5,6,7,8-Tetrahydroquinoxaline
also named Cyclohexapyrazine
Taytonn
5,6,7,8-Tetrahydroquinoxaline
Odor: Bean, Musty, Nutty, Roast
TCI AMERICA
For experimental / research use only.
5,6,7,8-Tetrahydroquinoxaline >98.0%(GC)(T)
Tengzhou Jitian Aroma Chemiclal
5,6,7,8-Tetrahydroquinoxaline
Tengzhou Xiang Yuan Aroma Chemicals
5.6.7.8-Tetrohydro quinoxaline
Tianjin Danjun International
5,6,7,8-Tetrahydroquinoxaline
Vigon International
Tetrahydroquinoxaline-5,6,7,8
WholeChem
5.6.7.8-Tetrahydroquinoxaline
Wujiang CIYUN Flavor & Fragrance
5,6,7,8-Tetrahydro Quinoxaline ≥98.0%
 
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
Xi - Irritant
R 36/37/38 - Irritating to eyes, respiratory system, and skin.
S 02 - Keep out of the reach of children.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 37/39 - Wear suitable gloves and eye/face protection.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: flavor and fragrance agents
Recommendation for nutty quinoxaline usage levels up to:
  0.1000 % in the fragrance concentrate.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 8.00 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): ND (μg/capita/day)
Structure Class: III
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 5
 average usual ppmaverage maximum ppm
baked goods: -5.00000
beverages(nonalcoholic): -5.00000
beverages(alcoholic): --
breakfast cereal: -2.00000
cheese: --
chewing gum: --
condiments / relishes: -2.00000
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: --
fruit ices: --
gelatins / puddings: -2.00000
granulated sugar: --
gravies: -2.00000
hard candy: -5.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: -2.00000
milk products: -1.00000
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: -2.00000
sugar substitutes: --
sweet sauces: --
 
Safety References:
European Food Safety Athority(efsa):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the Commission related to Flavouring Group Evaluation 17 (FGE.17): Pyrazine derivatives from chemical group 24 (Commission Regulation (EC) No 1565/2000 of 18 July 2000)
View page or View pdf

Flavouring Group Evaluation 50 (FGE.50): Consideration of pyrazine derivatives evaluated by JECFA (57th meeting) structurally related to pyrazine derivatives evaluated by EFSA in FGE.17 (2005) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf

Flavouring Group Evaluation 17, Revision 1 (FGE.17Rev1): Pyrazine derivatives from chemical group 24 - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) [1]
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 17, Revision 2 (FGE.17Rev2): Pyrazine derivatives from chemical group 24
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 50, Revision 1 (FGE.50Rev1): Consideration of pyrazine derivatives evaluated by JECFA (57th meeting) structurally related to pyrazine derivatives evaluated by EFSA in FGE.17Rev2 (2010)
View page or View pdf

Safety and efficacy of pyrazine derivatives including saturated ones belonging to chemical group 24 when used as flavourings for all animal species
View page or View pdf

EPI System: View
EPA Substance Registry Services (TSCA):34413-35-9
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :36822
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
5,6,7,8-tetrahydroquinoxaline
Chemidplus:0034413359
 
References:
 5,6,7,8-tetrahydroquinoxaline
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:34413-35-9
Pubchem (cid):36822
Pubchem (sid):134999131
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
CHEMBL:View
HMDB (The Human Metabolome Database):HMDB33154
FooDB:FDB011159
Export Tariff Code:2933.99.8090
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
FAO:5,6,7,8-Tetrahydroquinoxaline
 
Potential Blenders and core components note
For Odor
No odor group found for these
sulfuryl octanoate
FL/FR
sulfuryl butyrate
FL/FR
sulfuryl decanoate
FL/FR
sulfuryl hexanoate
FL/FR
sulfuryl isobutyrate
FL/FR
sulfuryl propionate
FL/FR
anisic
anisic
para-
anisaldehyde
FL/FR
balsamic
2-
acetyl furan
FL/FR
iso
butyl cinnamate
FL/FR
ethyl cinnamate
FL/FR
methyl cinnamate
FL/FR
3-
phenyl propyl alcohol
FL/FR
bready
coffee furanone
FL/FR
caramellic
cyclotene
FL/FR
immortelle absolute
FL/FR
maltol
FL/FR
iso
propenyl pyrazine
FL/FR
strawberry furanone
FL/FR
cereal
bran absolute
FR
chocolate
iso
amyl phenyl acetate
FL/FR
2,5-
dimethyl pyrazine
FL/FR
coconut
gamma-
nonalactone (aldehyde C-18 (so-called))
FL/FR
gamma-
octalactone
FL/FR
coffee
cichorium intybus root solid extract
FL/FR
corn chip
popcorn pyrimidine
FL/FR
earthy
nutty pyrazine
FL/FR
floral
bois de rose oil brazil
FL/FR
ethyl phenyl acetate
FL/FR
green
2-
heptyl furan
FL/FR
hay
beeswax absolute
FL/FR
honey
phenyl acetic acid
FL/FR
medicinal
quinoline
CS
musty
2-
acetyl pyrrole
FL/FR
3-
acetyl-2,5-dimethyl furan
FL/FR
hazelnut pyrazine
FL/FR
menthofuran
FL/FR
nutty
2-
acetyl-3-ethyl pyrazine
FL/FR
2-
acetyl-3-methyl pyrazine
FL/FR
2-
acetyl-3,5-dimethyl pyrazine
FL/FR
2-
acetyl-3,5(or 6)-dimethyl pyrazine
FL/FR
2-
acetyl-5-methyl furan
FL/FR
roasted
chestnut fragrance
FR
3,6-
cocoa pyrazine
FL/FR
4,5-
dimethyl-2-ethyl-3-thiazoline
FL/FR
2-
ethyl pyrazine
FL/FR
filbert heptenone
FL/FR
filbert heptenone B
FL/FR
filbert pyrazine
FL/FR
2,6-
lutidine
FL/FR
methoxymethyl pyrazine
FL/FR
5-
methyl quinoxaline
FL/FR
nutty cyclohexenone
FL/FR
sesame absolute
FL/FR
2,3,5,6-
tetramethyl pyrazine
FL/FR
2,3,5-
trimethyl pyrazine
FL/FR
vinyl sulfurol
FL/FR
popcorn
2-
acetyl pyrazine
FL/FR
2-
acetyl thiazole
FL/FR
powdery
para-
anisyl alcohol
FL/FR
spicy
cassia bark oil china
FL/FR
clove bud oil
FL/FR
alpha-
methyl cinnamaldehyde
FL/FR
sulfurous
dimethyl sulfide
FL/FR
furfuryl thioacetate
FL/FR
tonka
tonka bean absolute
FR
vanilla
ethyl vanillin
FL/FR
vanilla bean absolute (vanilla planifolia)
FL/FR
vanillyl acetate
FL/FR
woody
4-
hydroxybenzaldehyde
FL/FR
For Flavor
No flavor group found for these
acetyl acetaldehyde dimethyl acetal
FL
(E)-
aconitic acid
FL
cyclohexyl methyl pyrazine
FL
2,5-
diethyl thiazole
FL
6,7-
dihydro-2,3-dimethyl-5H-cyclopentapyrazine
FL
dimethyl dihydrocyclopentapyrazine
FL
6,7-
dimethyl dihydrocyclopentapyrazine
FL
2,5-
dimethyl pyrazine and 2,6-dimethyl pyrazine mixture
FL
2,5-
dimethyl thiazole
FL
methyl 2-(methyl thio) acetate
FL
pyrazines mixture
FL
sulfuryl butyrate
FL/FR
sulfuryl decanoate
FL/FR
sulfuryl hexanoate
FL/FR
sulfuryl isobutyrate
FL/FR
5-
acetyl-2,3-dihydro-1,4-thiazine
FL
sulfuryl formate
FL
sulfuryl octanoate
FL/FR
sulfuryl propionate
FL/FR
ammoniacal
ammoniacal
2-
methyl piperidine
FL
balsamic
iso
butyl cinnamate
FL/FR
ethyl cinnamate
FL/FR
bready
2-
propionyl thiazole
FL
brown
beeswax absolute
FL/FR
burnt
iso
propenyl pyrazine
FL/FR
buttery
diacetyl
FL
caramellic
caramel furanone
FL
cyclotene
FL/FR
maltol
FL/FR
strawberry furanone
FL/FR
coconut
gamma-
nonalactone (aldehyde C-18 (so-called))
FL/FR
coffee
cichorium intybus root solid extract
FL/FR
corn chip
2-
acetyl thiazole
FL/FR
2-
acetyl-2-thiazoline
FL
popcorn pyrimidine
FL/FR
creamy
para-
anisaldehyde
FL/FR
4-
hydroxybenzaldehyde
FL/FR
fatty
2-
heptyl furan
FL/FR
fishy
4,5-
dimethyl thiazole
FL
floral
iso
amyl phenyl acetate
FL/FR
bois de rose oil brazil
FL/FR
phenyl acetic acid
FL/FR
fruity
para-
anisyl alcohol
FL/FR
2-
ethyl-2,5-dihydro-4-methyl thiazole
FL
green
immortelle absolute
FL/FR
honey
ethyl phenyl acetate
FL/FR
lactonic
gamma-
octalactone
FL/FR
malty
yeast thiazoline
FL
musty
2,5-
dimethyl pyrazine
FL/FR
2-
ethoxythiazole
FL
hazelnut pyrazine
FL/FR
menthofuran
FL/FR
2,3,5-
trimethyl pyrazine
FL/FR
nutty
2-
acetyl furan
FL/FR
2-
acetyl pyrrole
FL/FR
3-
acetyl-2,5-dimethyl furan
FL/FR
3-
acetyl-2,5-dimethyl thiophene
FL
2-
acetyl-3-ethyl pyrazine
FL/FR
2-
acetyl-3-methyl pyrazine
FL/FR
2-
acetyl-3,5-dimethyl pyrazine
FL/FR
2-
acetyl-3,5(or 6)-dimethyl pyrazine
FL/FR
2-
acetyl-5-methyl furan
FL/FR
arachis hypogaea fruit extract
FL
3,6-
cocoa pyrazine
FL/FR
coffee furanone
FL/FR
4,5-
dimethyl-2-ethyl-3-thiazoline
FL/FR
2-
ethyl pyrazine
FL/FR
1-
ethyl-2-acetyl pyrrole
FL
filbert heptenone
FL/FR
filbert heptenone B
FL/FR
filbert pyrazine
FL/FR
2,6-
lutidine
FL/FR
methoxymethyl pyrazine
FL/FR
5-
methyl quinoxaline
FL/FR
nutty cyclohexenone
FL/FR
nutty pyrazine
FL/FR
nutty thiazole
FL
peanut oxazole
FL
sesame absolute
FL/FR
2,3,5,6-
tetramethyl pyrazine
FL/FR
vinyl sulfurol
FL/FR
popcorn
2-
propionyl-2-thiazoline
FL
roasted
2-
acetyl pyrazine
FL/FR
3,5-
diisobutyl-1,2,4-trithiolane
FL
furfuryl thioacetate
FL/FR
spicy
cassia bark oil china
FL/FR
clove bud oil
FL/FR
alpha-
methyl cinnamaldehyde
FL/FR
methyl cinnamate
FL/FR
3-
phenyl propyl alcohol
FL/FR
sulfurous
dimethyl sulfide
FL/FR
vanilla
ethyl vanillin
FL/FR
vanilla bean absolute (vanilla planifolia)
FL/FR
vanillyl acetate
FL/FR
 
Potential Uses:
FLbread
FLcaramel
FLcheese
FLchocolate cocoa
FLcorn
FLcorn chip
FRfilbert
FLmeat
FRpeanut
FLpecan
FRpopcorn
FLpotato
FLsesame
FRvanilla
FLwalnut
 
Occurrence (nature, food, other):note
 bread wheat bread
Search PMC Picture
 cocoa
Search Trop Picture
 coffee
Search PMC Picture
 filbert roasted filbert
Search Trop Picture
 hazelnut
Search Trop Picture
 peanut
Search Trop Picture
 peanut roasted peanut
Search Trop Picture
 sesame roasted sesame seed
Search Trop Picture
 
Synonyms:
 cyclohexapyrazine
 quinoxaline, 5,6,7,8-tetrahydro-
5,6,7,8-tetrahydro quinoxaline
 tetrahydro terrazine-014 (IFF)
 tetrahydroquinoxaline
5,6,7,8-tetrahydroquinoxaline
5,6,7,8-tetrahydroquinoxaline natural
5,6,7,8-tetrahydroquinoxaline natural 1% in ethyl alcohol
5,6,7,8-tetrahydroquinoxaline natural 5% in ethyl alcohol
 tetrahydroterrazine (IFF)
 
 
Notes:
Flavour ingredient. Present in wheat bread, cocoa, coffee, roasted filbert, roasted peanut, pork and roasted sesame
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