EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

2-ethyl-6-methyl pyrazine
2-ethyl-6-methylpyrazine

Supplier Sponsors

CAS Number: 13925-03-6Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:237-692-0
FDA UNII:A9BL9OKQ7T
Nikkaji Web:J121.830A
CoE Number:11331
XlogP3-AA:1.00 (est)
Molecular Weight:122.17070000
Formula:C7 H10 N2
NMR Predictor:Predict (works with chrome or firefox)
EFSA/JECFA Comments:
Mixture of positional isomers (2-Ethyl-5/6-ethylpyrazine), 2-5- (66 %) and 2-6-isomers (33%) (sum 97 %) (EFFA, 2010a). 95% (sum of 2,5- and 2,6-isomers); 60-63% 2,5-isomer and 30-35% 2,6-isomer. (EFSA)
Category:flavoring agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
JECFA Food Flavoring:769 2-ethyl-6-methylpyrazine
FLAVIS Number:14.114 (Old)
DG SANTE Food Flavourings:14.114 2-ethyl-6-methylpyrazine
FEMA Number:3919 2-methyl-6-ethylpyrazine
FDA:No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF):13925-03-6 ; 2-ETHYL-6-METHYLPYRAZINE
 
Physical Properties:
Appearance:colorless to pale yellow clear liquid (est)
Assay: 95.00 to 100.00 sum of isomers
Additional Assay Information:sum of 2,3- 2,5- and 2,6- isomers
Food Chemicals Codex Listed: No
Specific Gravity:0.96700 to 0.98000 @ 25.00 °C.
Pounds per Gallon - (est).: 8.046 to 8.155
Refractive Index:1.48700 to 1.49700 @ 20.00 °C.
Boiling Point: 80.00 °C. @ 50.00 mm Hg
Boiling Point: 170.00 to 171.00 °C. @ 760.00 mm Hg
Vapor Pressure:1.975000 mmHg @ 25.00 °C. (est)
Flash Point: 145.00 °F. TCC ( 62.78 °C. )
logP (o/w): 1.197 (est)
Soluble in:
 alcohol
 water
 water, 4903 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor Type: potato
Odor Strength:high ,
recommend smelling in a 0.10 % solution or less
roasted potato
Odor Description:at 0.10 % in dipropylene glycol. roasted potato
Flavor Type: nutty
roasted hazelnut hazelnut roasted hazelnut nutty
Taste Description: roasted hazelnut
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Axxence Aromatic
2-ETHYL-6-METHYL PYRAZINE Natural
Kosher
Sustainability
BOC Sciences
For experimental / research use only.
Pyrazine,2-ethyl-6-methyl-
Excellentia International
2-Ethyl-6-Methyl Pyrazine (Pyrazine Mix. # 10, 12, 14, 16, 18, 22, 26) Natural
M&U International
2-Ethyl-6-Methyl Pyrazine
Myrazine
2-Ethyl-6-methylpyrazine/EU Nat.
Myrazine
Pyrazine,2-ethyl-6-methyl-
Odor: roasted potato, Taste: roasted hazelnut
Parchem
2-ethyl-6-methyl pyrazine
Penta International
2-ETHYL-6-METHYL PYRAZINE NATURAL 5% IN ETHYL ALCOHOL
Penta International
2-ETHYL-6-METHYL PYRAZINE
Synerzine
natural 2-Ethyl-6-methylpyrazine
WholeChem
2-Ethyl-6-methylpyrazine
Chemical Sources Association
Need This Item for Flavor/Food?: You can contact the Chemical Sources Association
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: flavoring agents
Recommendation for 2-ethyl-6-methyl pyrazine usage levels up to:
 not for fragrance use.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 0.37 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 0.40 (μg/capita/day)
Structure Class: II
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 19
 average usual ppmaverage maximum ppm
baked goods: 3.000006.00000
beverages(nonalcoholic): 1.000003.00000
beverages(alcoholic): 0.100001.00000
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: 2.000003.00000
fruit ices: --
gelatins / puddings: 1.000003.00000
granulated sugar: --
gravies: --
hard candy: --
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: 1.000005.00000
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: 2.000005.00000
soups: --
sugar substitutes: --
sweet sauces: --
 
Safety References:
European Food Safety Athority(efsa):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the Commission related to Flavouring Group Evaluation 17 (FGE.17): Pyrazine derivatives from chemical group 24 (Commission Regulation (EC) No 1565/2000 of 18 July 2000)
View page or View pdf

Flavouring Group Evaluation 50 (FGE.50): Consideration of pyrazine derivatives evaluated by JECFA (57th meeting) structurally related to pyrazine derivatives evaluated by EFSA in FGE.17 (2005) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf

Flavouring Group Evaluation 17, Revision 1 (FGE.17Rev1): Pyrazine derivatives from chemical group 24 - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) [1]
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 17, Revision 2 (FGE.17Rev2): Pyrazine derivatives from chemical group 24
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 50, Revision 1 (FGE.50Rev1): Consideration of pyrazine derivatives evaluated by JECFA (57th meeting) structurally related to pyrazine derivatives evaluated by EFSA in FGE.17Rev2 (2010)
View page or View pdf

EPI System: View
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :26332
National Institute of Allergy and Infectious Diseases:Data
WISER:UN 1993
WGK Germany:3
2-ethyl-6-methylpyrazine
Chemidplus:0013925036
 
References:
 2-ethyl-6-methylpyrazine
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:13925-03-6
Pubchem (cid):26332
Pubchem (sid):134990415
Pherobase:View
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
HMDB (The Human Metabolome Database):HMDB41569
FooDB:FDB021559
Typical G.C.
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
 
Potential Blenders and core components note
For Odor
chocolate
cocoa hexenal
FL/FR
earthy
2-
ethyl-3-methoxypyrazine
FL/FR
nutty pyrazine
FL/FR
fruity
allyl 2-ethyl butyrate
FL/FR
nutty
2-
acetyl-3-ethyl pyrazine
FL/FR
2-
acetyl-3-methyl pyrazine
FL/FR
2-
acetyl-3,5-dimethyl pyrazine
FL/FR
2-
acetyl-3,5(or 6)-dimethyl pyrazine
FL/FR
3,6-
cocoa pyrazine
FL/FR
filbert heptenone
FL/FR
filbert heptenone B
FL/FR
(-)-(E,R)-
filbertone
FL/FR
(+)-(E,S)-
filbertone
FL/FR
european
hazelnut absolute
FL/FR
roasted
hazelnut infusions
FL/FR
european
hazelnut oil CO2 extract
FL/FR
2,4,5-
trimethyl oxazole
FL/FR
tobacco
3-
ethyl pyridine
FL/FR
methyl benzoxole
FL/FR
vegetable
methional
FL/FR
For Flavor
No flavor group found for these
2-
ethyl-3-methoxypyrazine
FL/FR
green pea pyrazine
FL
2-
methoxy-3-propyl pyrazine
FL
methyl 2-(methyl thio) acetate
FL
4-(
methyl thio) butanol
FL
alliaceous
alliaceous
3-
mercapto-2-pentanone
FL
2-
methyl thioacetaldehyde
FL
astringent
2-
methyl pyridine
FL
burnt
2-
methyl quinoxaline
FL
2,4,5-
trimethyl oxazole
FL/FR
caramellic
3-
ethyl pyridine
FL/FR
chocolate
chocolate hazelnut flavor
FL
cocoa
cocoa hexenal
FL/FR
earthy
(±)-2-
mercapto-5-methylheptan-4-one
FL
ethereal
allyl 2-ethyl butyrate
FL/FR
green
2,5-
dimethyl-4-ethyl oxazole
FL
3-
methyl pyridine
FL
1-(5-
methyl-2-furyl) propan-1-one
FL
propylene glycol acetone ketal
FL
milky
dextro,laevo-3-(
methyl thio) butanone
FL
nutty
3-
acetyl-2,5-dimethyl thiophene
FL
2-
acetyl-3-ethyl pyrazine
FL/FR
2-
acetyl-3-methyl pyrazine
FL/FR
2-
acetyl-3,5-dimethyl pyrazine
FL/FR
2-
acetyl-3,5(or 6)-dimethyl pyrazine
FL/FR
almond hazelnut flavor
FL
3,5(6)-
cocoa pyrazine
FL
3,6-
cocoa pyrazine
FL/FR
2,5-
diethyl pyrazine
FL
2,5-
diethyl-3-methyl pyrazine
FL
filbert flavor
FL
filbert heptenone
FL/FR
filbert heptenone B
FL/FR
(-)-(E,R)-
filbertone
FL/FR
(+)-(E,S)-
filbertone
FL/FR
european
hazelnut absolute
FL/FR
toasted
hazelnut cream flavor
FL
european
hazelnut distillates
FL
hazelnut flavor
FL
roasted
hazelnut infusions
FL/FR
european
hazelnut oil CO2 extract
FL/FR
european
hazelnut oleoresin
FL
hazelnut paste
FL
methyl benzoxole
FL/FR
nutty pyrazine
FL/FR
spicy
chocolate cinnamon hazelnut flavor
FL
cinnamon hazelnut cappuccino flavor
FL
cinnamon hazelnut cream flavor
FL
cinnamon hazelnut flavor
FL
sulfurous
potato butanone
FL
tomato
methional
FL/FR
vanilla
vanilla hazelnut flavor
FL
vegetable
potato butyraldehyde
FL
winey
5-
ethyl-2-methyl pyridine
FL
 
Potential Uses:
FLpotato
 
Occurrence (nature, food, other):note
 barley
Search Trop Picture
 cocoa butter
Search Trop Picture
 coffee
Search PMC Picture
 lavender oil spike spain @ 0.112%
Data GC Search Trop Picture
 peanut roasted peanut
Search Trop Picture
 tea leaf
Search Trop Picture
 
Synonyms:
2-ethyl-6-methyl pyrazine natural
2-ethyl-6-methyl-1,4-diazine
2-ethyl-6-methylpyrazine
2-ethyl-6-methylpyrazine natural
6-methyl-2-ethyl pyrazine
2-methyl-6-ethyl pyrazine
2-methyl-6-ethylpyrazine
 pyrazine, 2-ethyl-6-methyl-
 
 
Notes:
Found in roast peanuts, coffee beans, barley and cocoa butter. Flavouring agent for baked goods, confectionery and meat products
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