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4,5-dimethyl thiazole
4,5-dimethylthiazole

Supplier Sponsors

Name:4,5-dimethyl-1,3-thiazole
CAS Number: 3581-91-7Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:222-703-3
FDA UNII:U3RP5I088G
Nikkaji Web:J45.577F
Beilstein Number:0105694
MDL:MFCD00005336
CoE Number:11606
XlogP3-AA:1.80 (est)
Molecular Weight:113.18279000
Formula:C5 H7 N S
NMR Predictor:Predict (works with chrome or firefox)
Category:flavoring agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
JECFA Food Flavoring:1035 4,5-dimethylthiazole
FLAVIS Number:15.017 (Old)
DG SANTE Food Flavourings:15.017 4,5-dimethylthiazole
FEMA Number:3274 4,5-dimethylthiazole
FDA:No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm: 4,5-DIMETHYLTHIAZOLE
 
Physical Properties:
Appearance:colorless to yellow clear liquid (est)
Assay: 97.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:1.05500 to 1.08500 @ 25.00 °C.
Pounds per Gallon - (est).: 8.779 to 9.028
Specific Gravity:1.06700 to 1.07200 @ 25.00 °C.
Pounds per Gallon - est.: 8.879 to 8.920
Refractive Index:1.51000 to 1.53000 @ 20.00 °C.
Refractive Index:1.51600 to 1.52400 @ 20.00 °C.
Melting Point: 83.00 to 84.00 °C. @ 760.00 mm Hg
Boiling Point: 157.00 to 159.00 °C. @ 760.00 mm Hg
Boiling Point: 158.00 °C. @ 742.00 mm Hg
Vapor Pressure:3.456000 mm/Hg @ 25.00 °C. (est)
Vapor Density:3.8 ( Air = 1 )
Flash Point: 125.00 °F. TCC ( 51.67 °C. )
logP (o/w): 1.184 (est)
Soluble in:
 alcohol
 ether
 water, 1750 mg/L @ 25 °C (est)
Insoluble in:
 water
 
Organoleptic Properties:
Odor Type: fishy
Odor Strength:high ,
recommend smelling in a 0.10 % solution or less
roasted nutty fishy green shellfish
Odor Description:at 0.10 % in dipropylene glycol. roasted nutty fishy green boiled shrimp
fishy ammoniacal seafood savory
Odor Description:Fishy, amine and pyridine-like with shrimp and savory nuances
Mosciano, Gerard P&F 22, No. 3, 47, (1997)
Flavor Type: fishy
fishy earthy molasses savory
Taste Description: at 5.00 ppm. Fishy, pyidine-like with molasses and savory nuances
Mosciano, Gerard P&F 22, No. 3, 47, (1997)
Odor and/or flavor descriptions from others (if found).
Frutarom
4,5-DIMETHYLTHIAZOLE
Odor Description:Fish, Green, Nutty, Roast
Suggested Uses: Chocolate, Cocoa, Coffee, Meat, Nut, Shellfish
R C Treatt & Co Ltd
4,5-Dimethylthiazole Halal, Kosher
Odor Description:Nutty, green, roasted, meaty, boiled poultry
Taste Description:nutty
Used in condiments, soups and sauces at 20ppm, in bakery and confectionery at 10ppm.
Taytonn
4,5-Dimethylthiazole
Odor Description:Roast, Nutty, Green, Fish
 
Cosmetic Information:
None found
 
Suppliers:
Advanced Biotech
4,5 DIMETHYL THIAZOLE
Ambles Nature et Chimie
4.5-DIMETHYL THIAZOLE
Anhui Haibei
4,5-Dimethyl Thiazole
Odor: Roasted nutty fishy green boiled shrimp
Anhui Suzhou Jinli Aromatic Chemicals
4,5-Dimethyl Thiazole
Odor: faint scent , baked nut
Beijing Lys Chemicals
4,5-Dimethylthiazole
BOC Sciences
For experimental / research use only.
4,5-Dimethylthiazole
Charkit Chemical
DIMETHYLTHIAZOLE, 4,5- D1150 FEMA 3274
DeLong Chemicals America
4,5-Dimethylthiazole, Kosher
Endeavour Specialty Chemicals
4,5-Dimethylthiazole 98% F&F
Speciality Chemical Product Groups
Fleurchem
4,5-dimethyl thiazole
Frutarom
4,5-DIMETHYLTHIAZOLE
Odor: Fish, Green, Nutty, Roast
Use: Suggested Uses: Chocolate, Cocoa, Coffee, Meat, Nut, Shellfish
Jiangyin Healthway
4,5-Dimethyl Thiazole
New functional food ingredients
Jinan Enlighten Chemical Technology(Wutong Aroma )
4,5-Dimethyl thiazole, Kosherk
Lluch Essence
4,5-DIMETHYL TIAZOLE
M&U International
4,5-DIMETHYL THIAZOLE, Kosher
Matrix Scientific
For experimental / research use only.
4,5-Dimethylthiazole, 97%
Penta International
4,5-DIMETHYLTHIAZOLE, Kosher
R C Treatt & Co Ltd
4,5-Dimethylthiazole
Halal, Kosher
Odor: Nutty, green, roasted, meaty, boiled poultry
Flavor: nutty
Used in condiments, soups and sauces at 20ppm, in bakery and confectionery at 10ppm.
Reincke & Fichtner
4,5-Dimethylthiazole
Robinson Brothers
4,5-Dimethylthiazole F&F
https://www.robinsonbrothers.uk/chemistry-competences
Sigma-Aldrich
4,5-Dimethylthiazole, ≥97%, FG
Odor: meaty; nutty
Certified Food Grade Products
Sunaux International
4,5-Dimethyl Thiazole
Synerzine
4,5-Dimethylthiazole
Taytonn
4,5-Dimethylthiazole
Odor: Roast, Nutty, Green, Fish
TCI AMERICA
For experimental / research use only.
4,5-Dimethylthiazole >98.0%(GC)
Tengzhou Jitian Aroma Chemiclal
4,5-Dimethyl Thiazole
Tengzhou Xiang Yuan Aroma Chemicals
4,5-Dimethyl Thiazole
Vigon International
Dimethyl-4,5 Thiazole
WholeChem
4,5-Dimethylthiazole
Wujiang CIYUN Flavor & Fragrance
4,5-Dimethyl Thiazole ≥98.0%
 
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
Xn - Harmful.
R 10 - Flammable.
R 22 - Harmful if swallowed.
R 37/38 - Irritating to respiratory system and skin.
R 41 - Risk of serious damage to eyes.
S 02 - Keep out of the reach of children.
S 16 - Keep away from sources of ignition - No Smoking.
S 20/21 - When using do not eat, drink or smoke.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
gavage-rat LD50 [sex: M,F] 964.90 mg/kg
(Piccirillo et al., 1982a)

oral-rat LD50 960 mg/kg
SENSE ORGANS AND SPECIAL SENSES: CHROMODACYRORREA: EYE LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 1, Pg. 95, 1990.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: flavoring agents
Recommendation for 4,5-dimethyl thiazole usage levels up to:
 not for fragrance use.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 0.18 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 0.40 (μg/capita/day)
Structure Class: II
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 5
 average usual ppmaverage maximum ppm
baked goods: -10.00000
beverages(nonalcoholic): --
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: -20.00000
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: -10.00000
fruit ices: -10.00000
gelatins / puddings: -6.00000
granulated sugar: --
gravies: -20.00000
hard candy: -10.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: -20.00000
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: -20.00000
sugar substitutes: --
sweet sauces: --
 
Safety References:
European Food Safety Athority(efsa):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Flavouring Group Evaluation 21: Thiazoles, thiophene, thiazoline and thienyl derivatives from chemical group 29. Miscellaneous substances from chemical group 30. (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf

Flavouring Group Evaluation 76, (FGE.76)[1] - Consideration of sulphur-containing heterocyclic compounds evaluated by JECFA (59th meeting) structurally related to thiazoles, thiophene, thiazoline and thienyl derivatives from chemical group 29, miscellaneous substances from chemical group 30 evaluated by EFSA in FGE.21 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food
View page or View pdf

Flavouring Group Evaluation 21, Revision 1 (FGE.21Rev1): Thiazoles, thiophene, thiazoline and thienyl derivatives from chemical group 29 Miscellaneous substances from chemical group 30
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 76, Revision 1 (FGE.76Rev1): Consideration of sulphur-containing heterocyclic compounds evaluated by JECFA (59th meeting) structurally related to thiazoles, thiophene, thiazoline and thienyl derivatives from chemical group 29 and miscellaneous substances from chemical group 30 evaluated by EFSA in FGE.21Rev3
View page or View pdf

EPI System: View
Env. Mutagen Info. Center:Search
EPA Substance Registry Services (TSCA):3581-91-7
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :62510
National Institute of Allergy and Infectious Diseases:Data
WISER:UN 1992
WGK Germany:3
4,5-dimethyl-1,3-thiazole
Chemidplus:0003581917
RTECS:XJ4380000 for cas# 3581-91-7
 
References:
 4,5-dimethyl-1,3-thiazole
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:3581-91-7
Pubchem (cid):62510
Pubchem (sid):135020035
Flavornet:3581-91-7
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS):View
HMDB (The Human Metabolome Database):HMDB32976
FooDB:FDB010963
Export Tariff Code:2934.10.9000
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
 
Potential Blenders and core components note
For Odor
No odor group found for these
sulfuryl octanoate
FL/FR
sulfuryl butyrate
FL/FR
sulfuryl decanoate
FL/FR
sulfuryl hexanoate
FL/FR
sulfuryl isobutyrate
FL/FR
sulfuryl propionate
FL/FR
caramellic
caramellic
iso
propenyl pyrazine
FL/FR
chocolate
2,5-
dimethyl pyrazine
FL/FR
green
2-sec-
butyl-3-methoxypyrazine
FL/FR
2-
heptyl furan
FL/FR
nutty
2-
acetyl-3-methyl pyrazine
FL/FR
2-
acetyl-3,5-dimethyl pyrazine
FL/FR
2-
acetyl-3,5(or 6)-dimethyl pyrazine
FL/FR
3,6-
cocoa pyrazine
FL/FR
3,5-
cocoa pyrazine
FL/FR
filbert heptenone
FL/FR
filbert heptenone B
FL/FR
methoxymethyl pyrazine
FL/FR
nutty quinoxaline
FL/FR
sesame absolute
FL/FR
sulfurous
fish thiol
FL/FR
furfuryl thioacetate
FL/FR
For Flavor
No flavor group found for these
2-
acetyl-1-pyrroline
FL
2-
acetyl-2-pyrroline
FL
amyl amine
FL
butyl amine
FL
(±)-sec-
butyl amine
FL
iso
butyl amine
FL
6,7-
dihydro-2,3-dimethyl-5H-cyclopentapyrazine
FL
dimethyl dihydrocyclopentapyrazine
FL
6,7-
dimethyl dihydrocyclopentapyrazine
FL
2,5-
dimethyl pyrazine and 2,6-dimethyl pyrazine mixture
FL
2,5-
dimethyl thiazole
FL
ethyl amine
FL
hexyl amine
FL
methyl 2-(methyl thio) acetate
FL
2-
methyl butyl amine
FL
iso
pentylidene isopentyl amine
FL
phenethyl amine
FL
propionyl pyrroline 1% in vegatable oil triglyceride
FL
iso
propyl amine
FL
pyrazines mixture
FL
sulfuryl butyrate
FL/FR
sulfuryl decanoate
FL/FR
sulfuryl hexanoate
FL/FR
sulfuryl isobutyrate
FL/FR
thiazole
FL
(R)-N,N,alpha-
trimethyl benzyl amine
FL
tripropyl amine
FL
5-
acetyl-2,3-dihydro-1,4-thiazine
FL
sulfuryl formate
FL
sulfuryl octanoate
FL/FR
sulfuryl propionate
FL/FR
ammoniacal
ammoniacal
2-
methyl piperidine
FL
burnt
iso
propenyl pyrazine
FL/FR
fatty
2-
heptyl furan
FL/FR
fishy
3-
penten-2-one
FL
trimethyl amine
FL
fruity
2-
ethyl-2,5-dihydro-4-methyl thiazole
FL
musty
2,5-
dimethyl pyrazine
FL/FR
2-
ethoxythiazole
FL
nutty
3-
acetyl-2,5-dimethyl thiophene
FL
2-
acetyl-3-methyl pyrazine
FL/FR
2-
acetyl-3,5-dimethyl pyrazine
FL/FR
2-
acetyl-3,5(or 6)-dimethyl pyrazine
FL/FR
arachis hypogaea fruit extract
FL
3,6-
cocoa pyrazine
FL/FR
3,5-
cocoa pyrazine
FL/FR
1-
ethyl-2-acetyl pyrrole
FL
filbert heptenone
FL/FR
filbert heptenone B
FL/FR
methoxymethyl pyrazine
FL/FR
nutty quinoxaline
FL/FR
sesame absolute
FL/FR
popcorn
2-
propionyl-2-thiazoline
FL
roasted
3,5-
diisobutyl-1,2,4-trithiolane
FL
furfuryl thioacetate
FL/FR
rooty
guarana flavor
FL
sulfurous
fish thiol
FL/FR
vegetable
2-sec-
butyl-3-methoxypyrazine
FL/FR
 
Potential Uses:
FLbakery
 chocolate cocoa
FLcoffee
 condiment
 confection
FLcrab
FLgreen
FLpeanut
FLscallop
FLshrimp
 soup
 
Occurrence (nature, food, other):note
 coffee
Search PMC Picture
 krill
Search PMC Picture
 peach fruit
Search Trop Picture
 peanut roasted peanut
Search Trop Picture
 pork
Search PMC Picture
 scallop
Search PMC Picture
 shrimp
Search PMC Picture
 
Synonyms:
4,5-dimethyl thiazole, kosher
4,5-dimethyl-1,3-thiazole
 dimethyl-4,5 thiazole
4,5-dimethylthiazole
4,5-dimethythiazole
 shrimp thiazole
 thiazole, 4,5-dimethyl-
 
 
Notes:
Flavouring agent
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