2,3,5-trimethyl pyrazine
  • Advanced Biotech
  • Alfrebro
    • Alfrebro LLC
      Let's get reacquainted
      Building great taste with aroma chemicals, extracts, and distillates
      The Alfrebro brand was established in the early 1900s by Alex Fries & Brothers, a Cincinnati Flavor Company. In 1980, the brand was re-launched as an aroma chemical manufacturer. Since its inception, Alfrebro’s primary focus has been to provide quality natural and high value synthetic chemicals.
      Email: Sarah Forbis
      Email: Sales
      Voice: 513-539-3021
      Fax: 513-539-7372
      US Voice: 513-539-7373
  • Apiscent Labs
    • Apiscent Labs, LLC
      Delivery of Quality
      Custom manufacturer and international supplier of fine ingredients.
      We believe inspired chemistry enriches lives. That's why our team is guided by a mission to provide fine ingredients to the worldwide pharmaceutical, flavor and fragrance markets with a primary focus on the manufacturing of value-added, research-based molecules. We're innovative problem solvers committed to excellence at every phase. Our work builds the foundation for our clients' continued success.
      Email: Info
      Email: Carl Sheeley
      Email: Customer Service
      Voice: +1 (414) 744 3993
      Fax: +1 (414) 744 7111
  • Axxence Aromatic
    • Axxence Aromatic GmbH
      We bring nature to your flavour
      Dedicated to provide the best possible quality and supply service of natural aroma ingredients.
      Axxence Aromatic is entirely dedicated to provide the best possible quality and supply service of natural aroma ingredients to the Flavour & Fragrance Industry worldwide.
      Email: Service
      Voice: +49.2822.68561.0
      Fax: +49.2822.68561.39
      Products List: View
      324400 2,3,5-TRIMETHYL PYRAZINE Natural Kosher
  • Beijing Lys Chemicals
    • Beijing Lys Chemicals Co, LTD.
      From Grams to Tons
      Fine chemical high-tech company which contains R&D, production, and sales.
      BEIJING LYS CHEMICALS CO, LTD, established in 2004, is a fine chemical high-tech company which contains R&D, production, and sales. We mainly engaged in export and technology development of flavor and fragrance materials and pharmaceutical intermediates. We have nearly 500 kinds of products, from grams to tons, exported to USA, Europe, South Asia and etc. And we custom manufacture new products according to customers’ needs, and serve good quality products and service. Our goal is to become a fine chemical enterprise which could provide special products and services.
      Email: Mr. Jia
      Email: Mr. Guo
      Voice: 86-10-68418738
      Fax: 86-10-68418739
      Mr. Guo86-10-68483445
      Mr. Guo86-10-68418739
      10033 2,3,5-Trimethylpyrazine
  • Berjé
    • Berjé Inc.
      The solution is clear
      Where the world comes to its senses - Berjé is a global distributor of Essential Oils and Aromatic Chemicals.
      Berjé is a family-owned business that has been in operation for six decades. The company's origins and strength lie in a profound understanding of the supply and the quality of the diverse raw materials consumed by the flavor and fragrance industries. This base was expanded upon more than two decades ago to include fragrance production. The company's unparalleled raw material expertise is focused on the supply of essential oils and aromatic chemicals. This is supported by our long-standing relationships with a worldwide fabric of producers ensuring the greatest prospects for uninterrupted supply in markets that are often volatile and unpredictable.
      Email: For Information
      Email: For Sales
      Voice: 973-748-8980
      Fax: 973-680-9618
      2,3,5-Trimethyl Pyrazine
      2,3,5-Trimethyl Pyrazine Natural
  • DeLong Chemicals America
    • DeLong Chemicals America
      Custom Manufacturing
      Supplier of aroma chemicals, pharmaceutical and specialty chemical intermediates.
      DeLong Chemicals America, LLC is an extension of Shijiazhuang Lida Chemical Co, Ltd to North America, a leading supplier and manufacturer of aroma chemicals, serving the industries of food, tobacco and perfume, while also providing intermediates, custom synthesis and custom manufacturing for pharmaceutical and specialty chemical industries.
      US Email: Customer Service
      US Email: Sales
      US Voice: (203) 271-9017
      9866 2,3,5-Trimethylpyrazine, Kosher
  • Elan Inc.
    • Elan Inc.
      Legacy of Innovation
      Highest quality natural and synthetic products.
      Elan Inc. is a privately held business that has been in operation for over 30 years. Our offices and production facility are located in Newark, NJ. We are dedicated to producing the highest quality natural and synthetic products available in the flavor and fragrance industry.
      US Email: Mr. David Pimentel
      US Email: Ms. Isabel Couto
      Email: Elan (Shanghai) Fine Chemical
      Email: Elan do Brazil
      US Voice: (973) 344-8014
      US Fax: (973) 344 -5880
      Voice: +86 021 57448053 (Elan Shanghai)
      Fax: +86 021 57448054 (Elan Shanghai)
      Elan do Brazil:55 13 3261 6084
      Elan do Brazil Fax:55 13 3261 3726
      2,3,5-TRIMETHYL PYRAZINE Kosher
  • Firmenich
    • Firmenich Inc.
      We Create
      We create perfumes and flavors for the World's most desirable brands.
      Firmenich is the largest privately-owned company in the perfume and flavor business. Swiss and family owned, we have created many of the world’s favorite perfumes for over 100 years and produced a number of the most well known flavors we enjoy each day.
      US Email: Fred Keifer
      US Voice: +1 609 452 1000
      US Fax: +1 609 452 6077
      956348 2,3,5-Trimethylpyrazine Nat min. 97%, Kosher

      2,3,5-TRIMETHYLPYRAZINE brings toasted notes which are excellent for grilled profile to meat flavors. Essential for chocolate, nut and coffee flavors.
  • Fleurchem
    • Fleurchem, Inc.
      Have A Flavorful Day
      A leading global manufacturer and supplier of ingredients for Flavors, Fragrances, AromaTherapy, Foods, Beverages, Personal Care Products, and other uses.
      Operating out of the 200,000 sq. ft., former Hercules/PFW facility in Middletown, NY; Fleurchem produces a full range of natural isolates, synthetic chemicals & specialities, essential oils and flavors. Additionally, the company performs toll manufacturing, as well as custom chemical synthesis for a wide range of clients.
      Email: Information
      US Voice: 845-341-2100
      US Fax: 845-341-2121
      trimethyl pyrazine natural
      2,3,5-trimethyl pyrazine
  • Frutarom
  • Indukern F&F
  • Jinan Enlighten Chemical Technology
    • Jinan Enlighten Chemical Technology Co Ltd
      Sincere Service
      Relying on solid technical force and abundant production experience.
      Jinan Enlighten Chemical Technology Co., Ltd. specializes in the development and production of pharmaceutical intermediates and pesticide intermediates. Relying on abundant fine chemicals production experience, advanced processing equipment, complete inspection method, perfect quality assurance system and reasonable after-sale service, the company has established solid cooperation relationship with many research institutes and colleges. Jinan Enlighten Chemical Technology Co., Ltd. is the wholly-owned subsidiary of Tengzhou Enlighten Spice Co., Ltd., which was founded in June 1, 1988. The parent company is the vice chairman of Chinese Flavor Cosmetics Industry Association, director of Chinese Food Additive Production Application Industry Association; it is a high-tech enterprise owning the most complete heterocyclic ring and sulfur-containing spice, the largest scale and the strongest R&D capacity; it owns enterprise technology center affirmed by governing unit and heterocyclic compound engineering and technological research center.
      Email: Info
      Email: Anna Lee
      Voice: +86-531-83197198
      Fax: +86-632-5038060
      Anna Lee Skype Skype
      Products List: View
      9905 2,3,5-Trimethyl pyrazine, Kosherk
  • Lluch Essence
    • Lluch Essence S.L.
      A family company dedicated to sales and distribution
      Flexibility, availability, price and quality.
      Flexibility, availability, price and quality make LLUCH ESSENCE S.L. one of Europe’s references when it comes to essential oils and aroma chemicals, and it is now well known all around the world.
      Email: Info
      Voice: 34 93 379 38 49
      Fax: 34 93 370 65 04
  • M&U International
    • M&U International LLC
      Steady supply & demand
      Meeting customers increasing demands at home as well as abroad.
      M&U dedicates itself to the development and production of new products as well as continuously promoting those new products. We’ve maintained a steady supply&demand relationship with a large number of manufacturers at home and abroad. We’ve developed an extensive network and because of our relationships with these manufacturers, we’re able to provide a stable supply of great quality materials. We’re located in China’s largest communications hub, Shanghai and in the U.S. near one of the largest sea ports on the East Coast. The strategic locations of our facilities ensure convenient, prompt and secure delivery of our products to our customers. We warmly welcome your inquiries, come witness our solemn commitment for yourself.
      Email: Sales
      US Email: Sales
      Voice: +86-21-32515501 60762991 60762992
      Fax: +86-21-32515502 64204960
      US Voice: 908-359-9000
      US Fax: 908-359-9002
      H0006 2,3,5-TRIMETHYL PYRAZINE, Kosher
  • Natural Advantage
    • Natural Advantage
      Manufacturer of natural flavor ingredients
      With over 25 years experience in the flavor and food ingredient industries.
      Natural Advantage was formed over seventeen years ago to supply the growing demand for natural food and flavor ingredients. We employ a wide range of multi-disciplined scientists who are dedicated to high quality service, customer satisfaction and creating an outstanding value for our clients.
      Email: Info
      Email: Customer service
      Voice: 318-215-1456
      Fax: 318-335-1579
      Products List: View
      Trimethyl Pyrazines

      Flavor Use: Coffee, nut, chocolate, cocoa and potato. Use Level: 0.01 – 5ppm
  • Penta International
    • Penta International Corporation
      Chemistry innovation
      At Penta, our products and services help businesses do business better.
      For over 30 years, Penta Manufacturing Company has played a growing role in worldwide chemistry innovations and applications. As an industry leader, Penta continues to pioneer chemistry-based solutions for practically every area of commerce. Our products and expertise have helped fuel technical advances in dozens of commercial applications including flavoring, coloring, fragrances and chemical processes.
      US Email: Technical Services
      US Email: Sales
      US Voice: (973) 740-2300
      US Fax: (973) 740-1839
      20-83800 2,3,5-TRIMETHYL PYRAZINE, Kosher
      20-84000 2,3,5-TRIMETHYL PYRAZINE, NATURAL, Kosher
  • Phoenix Aromas & Essential Oils
    • Phoenix Aromas & Essential Oils, Inc.
      EXCEPTIONAL Flavor and Fragrance Ingredients
      Phoenix sources the finest flavor and fragrance ingredients for its customers.
      Phoenix Aromas & Essential Oils LLC was founded in 1994, grounded in a simple set of core values: provide top-quality products, cost-effective pricing and personalized attention to all our customers. After two decades, we remain committed to those values. With extensive market knowledge of our products, we anticipate, as opposed to merely react, to industry challenges. You can rely on us for all your flavor and fragrance ingredient needs. Customers benefit from Phoenix's long-standing relationships with experienced and reputable growers, processors and manufacturers in key global locations, who are committed to sustainability and green programs. With a strategically located 80,000 sq-ft facility, customers can rely on Phoenix to deliver quality products on time, and cost-effectively.
      Email: EU Info
      US Email: Info
      US Email: Sales
      Voice: +44(0) 208 532 1022
      Fax: +44(0) 208 532 1023
      US Voice: 201-784-6100
      US Fax: 201-784-8566
      Pyrazine, 2,3,5- Trimethyl
      Pyrazine, 2,3,5-Trimethyl Natural
  • Pyrazine Specialties
    • Pyrazine Specialties, Inc.
      Naturally Better
      First in pyazines for the food, perfume, and pharmaceutical industry.
      Pyrazine Specialties, Incorporated began almost 40 years ago in a modest little building near the Georgia Tech campus. Today, Pyrazine Specialties is looking to expand its facilities as well as significantly increase our product line.
      US Email: Customer Service
      US Email: Sales
      US Voice: (404) 524-6744
      US Fax: (404) 577-1651
      735 2,3,5-Trimethylpyrazine
  • Riverside Aromatics
    • Riverside Aromatics Ltd.
      Speciality Aroma Chemicals, Naturals and Synthetics
      Specialist raw material suppliers to the Flavour & Fragrance Industry.
      Peter Cannon & David Rowe established Riverside Aromatics in 2006 in Poole, UK, to offer a new type of specialist raw material supplier to the Flavour & Fragrance Industry. We bring together over 40 years of commercial & technical experience in the F&F industry which allows us to understand the needs of the Global F&F business and especially that of the West European Market.
      Email: Info
      Email: Peter Cannon (sales)
      Voice: +44 (0) 1202 679532
      Fax: +44 (0) 1202 679532
      Products List: View
      TP0300 2,3,5-Trimethylpyrazine
      NP1300 2,3,5-Trimethylpyrazine Natural
  • Robertet
  • SAFC Global
    • SAFC
      Complete Supply Chain
      The perfect blend of products and services that bring your creativity to life.
      Sigma-Aldrich is a leading Life Science and High Technology company dedicated to providing high-quality, safe and certified flavor ingredients with transparent and easily accessible documentation to customers around the globe. Sigma-Aldrich also provides a suite of analytical tools that allow food analysts to simplify sample preparation, cleanup and analysis steps, while increasing sensitivity to trace ingredients and harmful substances to meet regulations and quality standards.
      Email: Information
      US Email: Sales
      US Voice: 800-244-1173
      US Fax: 800-368-4661
      W324418 2,3,5-Trimethylpyrazine ≥99%, FCC, Kosher, FG
      W324426 2,3,5-Trimethylpyrazine natural ≥80%, FG, Kosher
  • Sunaux International
    • Sunaux International
      Buy With Confidence
      We have industry leading processes and procedures to ensure nothing but the most reliable product.
      Sunaux International was founded in 2012 by the owner Mr.John Felton after spending 18 years involved in developing global business in the aromatic chemicals, fragrance and flavour compounds business.
      Email: John Felton
      Email: Stephen Zhou (Sales)
      Voice: 0512-57995626
      Fax: 0512-57570299
      H0006 2,3,5-Trimethyl Pyrazine
  • Taytonn
      Supplying Asia Pacific
      We fully understand the demands of the F&F industry and we endeavour to supply quality products, with ready availability and a personalised service.
      Since 2001 TAYTONN has been distributing key ingredients to the Fragrance and Flavor industry in Asia. We work closely with customers, principals and vendors. Together we forecast demand and match it with supply of aroma chemicals, essential oils and natural isolates & extracts. Sourced from around the world, our F&F ingredient inventory in Singapore is ready to ship to any location in Asia and beyond. Time and again, we help our principals introduce new discoveries to the F&F market - stimulating creativity and bringing value added proposition to our customers.
      Email: Info
      Email: Sales
      Voice: + 65 - 6861 8113
      Fax: + 65 - 6861 8115
      Natural Trimethylpyrazine
  • Treatt
    • Treatt PLC
      Full Range of Naturals
      World-leading, independent ingredients supplier to the flavour and fragrance industries.
      We are proud of our heritage in trading essential oils. Our founder Richard Court Treatt's charismatic and personable approach still embodies the spirit of Treatt today.
      Email: Enquiries
      US Email: Enquiries
      Voice: +44 (0) 1284 702500
      Fax: +44 (0) 1284 703809
      US Voice: +1 863 668 9500
      US Fax: +1 863 668 3388
      2,3,5-Trimethylpyrazine NI, Kosher
      Odour threshold in water: 400 ppb
      Much used as a component in modern cocoa and chocolate flavors. Also used in coffee, bread and roast nut flavours (e.g., hazelnut, almond, peanut, etc.). Normal use levels in finished consumer product: 0.01-5 ppm. Council of Europe limits: Foods (1 ppm).
Synonyms   Articles   Notes   Search
    Flavor Demo Formulas
2,3,5-trimethylpyrazine (Click)
CAS Number: 14667-55-1
ECHA EC Number: 238-712-0
Beilstein Number: 0002423
MDL: MFCD00006145
FEMA Number: 3244
CoE Number: 735
XlogP3: 1.00 (est)
Molecular Weight: 122.17070000
Formula: C7 H10 N2
NMR Predictor: Predict
EFSA/JECFA Comments: Specific gravity: depending on the quality and the producer, the SG ranges from: 0.967-0.987 (EFFA, 2010a).
Category: cosmetic, flavor and fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist: Search
Google Patents: Search
US Patents: Search
EU Patents: Search
IBM Patents: Obtain
Pubchem Patents: Search
PubMed: Search
NCBI: Search
Read: Under the conditions of intended use - New developments in the FEMA GRAS program and the safety assessment of flavor ingredients
Read: A GRAS assessment program for flavor ingredients
Read: Sensory testing for flavorings with modifying properties. Food Technology
Read: Criteria for the safety evaluation of flavoring substances
Read: A procedure for the safety evaluation of natural flavor complexes used as ingredients in food: essential oils
Read: FEMA Expert Panel: 30 Years of safety evaluation for the flavor industry
Read: Consumption ratio and food predominance of flavoring materials
JECFA Food Flavoring: 774  2,3,5-trimethylpyrazine
Flavis Number: 14.019 (Old)
EU SANCO Food Flavourings: 14.019  2,3,5-trimethylpyrazine

FEMA Number: 3244  2,3,5-trimethylpyrazine
Synonyms   Articles   Notes   Search   Top
Physical Properties:
Appearance: colorless to pale yellow clear liquid (est)
Assay: 98.00 to 100.00 % 
Food Chemicals Codex Listed: Yes
Specific Gravity: 0.97500 @  25.00 °C.
Boiling Point: 171.00 to  172.00 °C. @ 760.00 mm Hg
Vapor Pressure: 1.724000 mm/Hg @ 25.00 °C. (est)
Vapor Density: 4.2 ( Air = 1 )
Flash Point: 130.00 °F. TCC ( 54.44 °C. )
logP (o/w): 0.950
Synonyms   Articles   Notes   Search   Top
Organoleptic Properties:
Odor Type: nutty
Odor Strength: high ,
recommend smelling in a 0.10 % solution or less
Odor Description:
at 0.10 % in dipropylene glycol. 
nutty musty earthy powdery cocoa roasted peanut
Odor Description:
Nutty, musty, powdery cocoa, potato and musty
Mosciano, Gerard P&F 15, No. 6, 35, (1990)
Taste Description:
at 80.00 ppm.  
Raw, musty, nutty, potato
Mosciano, Gerard P&F 15, No. 6, 35, (1990)
Synonyms   Articles   Notes   Search   Top
Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: perfuming agents
Synonyms   Articles   Notes   Search   Top
Advanced Biotech
Advanced Biotech
95% min. (mixed isomers)
Odor: Baked-Potato, Peanut Butter, Roasted
Odor: Baked Potato, Peanut
Odor: Roasted Nuts, Cocoa, Baked Potato
Anhui Haibei
2,3,5-Trimethyl Pyrazine natural
Odor: Nutty musty earthy powdery cocoa roasted peanut
Anhui Haibei
2,3,5-Trimethyl Pyrazine
Odor: Nutty musty earthy powdery cocoa roasted peanut
Anhui Suzhou Jinli Aromatic Chemicals
2,3,5-Trimethyl Pyrazine
Odor: roast, peanut, hazelnut, cocoa
Apiscent Labs
Odor: Roast, peanut, filbert, cocoa
2,3,5-Trimethyl Pyrazine Natural
Entire library of synthetic pyrazines is available.
Astral Extracts
Axxence Aromatic
Beijing Lys Chemicals
2,3,5-Trimethyl Pyrazine Natural
2,3,5-Trimethyl Pyrazine
CG Herbals
2,3,5-Trimethyl Pyrazine
Odor: Nutty, Baked potato, Roasted peanut, Cocoa, Burnt notes
Charkit Chemical
Citrus and Allied Essences
2,3,5-Trimethyl Pyrazine FCC
Odor: reminiscent of baked potato or roasted peanut
Market Report
De Monchy Aromatics
DeLong Chemicals America
2,3,5-Trimethylpyrazine, Kosher
Elan Inc.
Endeavour Speciality Chemicals
2,3,5-Trimethylpyrazine 99%
Ernesto Ventós
Ernesto Ventós
2,3,5-Trimethylpyrazine Nat
min. 97%, Kosher
Flavor: Powerful toasted, nutty, earthy, chocolate and coffee notes
2,3,5-TRIMETHYLPYRAZINE brings toasted notes which are excellent for grilled profile to meat flavors. Essential for chocolate, nut and coffee flavors.
2,3,5-trimethyl pyrazine
trimethyl pyrazine natural
2,3,5-trimethyl pyrazine
≥99.50%, NI, Kosher
Odor: Cocoa, Earthy, Musty, Nutty
Use: Suggested Uses: Chocolate, Cocoa, Coffee, Nut, Savoury, Shellfish
10% IN PG, NI, Kosher
Odor: Chocolate, Cocoa, Nutty
Use: Suggested Uses: Chocolate, Cocoa, Coffee
≥80.00%, natural, Kosher
Odor: Caramel, Cocoa, Earthy, Musty, Nutty
Use: Suggested Uses: Alcoholic Beverages, Chocolate, Cocoa, Coffee, Meat, Nut
Indukern F&F
Jinan Enlighten Chemical Technology
2,3,5-Trimethyl pyrazine, Kosherk
Kunshan Sainty
2,3,5-Trimethyl Pyrazine, Kosher
Kunshan Sainty
2,3,5-Trimethyl Pyrazine, Natural
Lluch Essence
Lluch Essence
M&U International
2,3,5-trimethyl pyrazine
Odor: roasted hazel-nut, peanuts, potato
Natural Advantage
Trimethyl Pyrazines
Flavor: Coffee, nut, chocolate, cocoa and potato
Flavor Use: Coffee, nut, chocolate, cocoa and potato. Use Level: 0.01 – 5ppm
Pearlchem Corporation
2,3,5-Trimethyl Pyrazine
Penta International
Penta International
Phoenix Aromas & Essential Oils
Pyrazine, 2,3,5- Trimethyl
Phoenix Aromas & Essential Oils
Pyrazine, 2,3,5-Trimethyl Natural
Pyrazine Specialties
Reincke & Fichtner
2,3,5-Trimethyl Pyrazine natural
Reincke & Fichtner
2,3,5-Trimethyl Pyrazine
Riverside Aromatics
2,3,5-Trimethylpyrazine Natural
Riverside Aromatics
Pure & Nat (EU)
Crops calendar
SAFC Global
2,3,5-Trimethylpyrazine natural
≥80%, FG, Kosher
SAFC Global
≥99%, FCC, Kosher, FG
Odor: chocolate; hazelnut
Shijiazhuang Lida Chemicals
Sunaux International
2,3,5-Trimethyl Pyrazine
Odor: Cocoa, Earthy, Musty, Nutty
Natural Trimethylpyrazine
Odor: Caramellic/ Caramel, Cocoa, Earthy, Myrrh, Nutty
Tengzhou Jitian Aroma Chemiclal
2,3,5-Trimethyl Pyrazine
The Perfumers Apprentice
Trimethyl Pyrazine 10% (PG)
Odor: nutty musty earthy powdery cocoa roasted peanut
NI, Kosher
Odor: Nutty, baked potato, roasted peanut, cocoa, burnt notes
Use: Odour threshold in water: 400 ppb
Flavor: nutty
Much used as a component in modern cocoa and chocolate flavors. Also used in coffee, bread and roast nut flavours (e.g., hazelnut, almond, peanut, etc.). Normal use levels in finished consumer product: 0.01-5 ppm. Council of Europe limits: Foods (1 ppm).
Vigon International
Trimethyl-2,3,5 Pyrazine
Vigon International
Trimethyl 2,3,5 Pyrazine Natural
WEN International
Wujiang CIYUN Flavor & Fragrance
2,3,5-Trimethyl Pyrazine ≥99.0%
Synonyms   Articles   Notes   Search   Top
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
Xn - Harmful.
R 10 - Flammable.
R 22 - Harmful if swallowed.
R 36/37/38 - Irritating to eyes, respiratory system, and skin.
S 02 - Keep out of the reach of children.
S 16 - Keep away from sources of ignition - No Smoking.
S 20/21 - When using do not eat, drink or smoke.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 37/39 - Wear suitable gloves and eye/face protection.
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
gavage-rat LD50  806 mg/kg
(Moran et al., 1980)

oral-rat LD50  806 mg/kg
Drug and Chemical Toxicology. Vol. 3, Pg. 249, 1980.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Synonyms   Articles   Notes   Search   Top
Safety in Use Information:
Category: cosmetic, flavor and fragrance agents
Recommendation for 2,3,5-trimethyl pyrazine usage levels up to:
  0.1000 % in the fragrance concentrate.
Maximised Survey-derived Daily Intakes (MSDI-EU): 100.00 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 46.00 (μg/capita/day)
Structure Class: II
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 4
Click here to view publication 4
 average usual ppmaverage maximum ppm
baked goods: 5.0000010.00000
beverages(nonalcoholic): 5.0000010.00000
beverages(alcoholic): --
breakfast cereal: -2.00000
cheese: --
chewing gum: --
condiments / relishes: -2.00000
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: --
fruit ices: --
gelatins / puddings: --
granulated sugar: --
gravies: -2.00000
hard candy: 5.0000010.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: -2.00000
milk products: -1.00000
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: -2.00000
sugar substitutes: --
sweet sauces: --
Synonyms   Articles   Notes   Search   Top
Safety References:
European Food Safety Athority(efsa): Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...
Flavor & Extract Manufacturers Association (FEMA) reference(s):
The FEMA GRAS assessment of pyrazine derivatives used as flavor ingredients.View pdf
EPI System: View
Chemicalize.org: Calculate predicted properties
Chemical Carcinogenesis Research Information System: Search
Env. Mutagen Info. Center: Search
EPA Substance Registry Services (TSCA): 14667-55-1
EPA ACToR: Toxicology Data
National Institute of Allergy and Infectious Diseases: Data
WISER: UN 1993
WGK Germany: 3
Chemidplus: 0014667551
RTECS: UQ3907000 for cas# 14667-55-1
Synonyms   Articles   Notes   Search   Top
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 14667-55-1
Pubchem (cid): 26808
Pubchem (sid): 134989811
Flavornet: 14667-55-1
Pherobase Floral: View
Synonyms   Articles   Notes   Search   Top
Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS): View
HMDB (The Human Metabolome Database): HMDB31844
YMDB (Yeast Metabolome Database): YMDB01442
Export Tariff Code: 2933.90
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
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Potential Blenders and core components note
2-acetyl pyrazineFL/FR
2-acetyl pyridineFL/FR
3-acetyl pyridineFL/FR
2-acetyl pyrroleFL/FR
2-acetyl thiazoleFL/FR
3-acetyl-2,5-dimethyl furanFL/FR
2-acetyl-3-ethyl pyrazineFL/FR
2-acetyl-3-methyl pyrazineFL/FR
2-acetyl-3,5(or 6)-dimethyl pyrazineFL/FR
2-acetyl-5-methyl pyrazineFL
2-acetyl-6-methyl pyrazineFL
 cocoa butenalFL/FR
 cocoa hexenalFL/FR
 cocoa pentenalFL/FR
3,5-cocoa pyrazineFL/FR
3,6-cocoa pyrazineFL/FR
 cyclohexyl methyl pyrazineFL
2,5-diethyl thiazoleFL
 dimethyl dihydrocyclopentapyrazineFL
2,5-dimethyl pyrazineFL/FR
2,5-dimethyl thiazoleFL
4,5-dimethyl thiazoleFL
 ethyl dimethyl pyrazineFL
2-ethyl pyrazineFL/FR
5-ethyl-2-methyl pyridineFL
2-ethyl-6-methyl pyrazineFL
 filbert heptenoneFL/FR
 furfuryl thioacetateFL/FR
 green pea pyrazineFL
 hazelnut pyrazineFL/FR
2-heptyl furanFL/FR
2-methoxy-3-propyl pyrazineFL
 methyl 2-(methyl thio) acetateFL
2-methyl thio-3,5 or 6-methyl pyrazineFL/FR
4-(methyl thio) butanolFL
dextro,laevo-3-(methyl thio) butanoneFL
2-methyl thioacetaldehydeFL
 nutty pyrazineFL/FR
 nutty quinoxalineFL/FR
 popcorn pyrimidineFL/FR
 potato butanoneFL
 potato butyraldehydeFL
2-propionyl pyrroleFL
2-propionyl thiazoleFL
 propylene glycol acetone ketalFL
 sulfuryl butyrateFL/FR
 sulfuryl decanoateFL/FR
 sulfuryl formateFL
 sulfuryl hexanoateFL/FR
 sulfuryl isobutyrateFL/FR
 sulfuryl octanoateFL/FR
 sulfuryl propionateFL/FR
2,3,5,6-tetramethyl pyrazineFL/FR
 vinyl sulfurolFL/FR
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Potential Uses:
 chocolate cocoa 
 nut peanutFL
 potato chip 
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Natural Occurrence in: note
 almond roasted almond
 barley roasted barley
GRIN Trop Picture
 bread wheat bread
 cheese emmental cheese
GRIN Trop Picture
 dairy products
 filbert roasted filbert
 lavender oil spike spain @ 0.062%
Data  GC  GRIN Trop Picture
GRIN Trop Picture
 potato chip
 soy products
 tobacco burley tobacco
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 cocoa pyrazine base
 potato pyrazine
 pyrazine TMPK (2,3,5 trimethylpyrazines) pure
 pyrazine, 2,3,5- trimethyl
 pyrazine, 2,3,5-trimethyl natural
 pyrazine, 2,3,5-trimethyl-
2,3,5-tri methyl pyrazine
 trimethyl 2,3,5 pyrazine natural
2, 3, 5 trimethyl pyrazine
2,3,5-trimethyl pyrazine
2,3,5-trimethyl pyrazine FCC
 trimethyl pyrazine natural
2,3,5-trimethyl pyrazine natural
2,3,5-trimethyl pyrazine, kosher
 trimethyl-2,3,5 pyrazine
2,3,5-trimethylpyrazine nat
2,3,5-trimethylpyrazine natural
2,3,5-trimethylpyrazine, natural
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US Patents: 3,931,166 - Certain 2,5-dimethyl-3-thiopyrazines
PubMed: Development of a novel method for hot-pressure extraction of protein from chicken bone and the effect of enzymatic hydrolysis on the extracts.
PubMed: Characterization of the key aroma compounds in beef extract using aroma extract dilution analysis.
PubMed: Determination of the alkylpyrazine composition of coffee using stable isotope dilution-gas chromatography-mass spectrometry (SIDA-GC-MS).
PubMed: Characterization of cocoa liquors by GC-MS and LC-MS/MS: focus on alkylpyrazines and flavanols.
PubMed: Characterization of aroma compounds of chinese "Wuliangye" and "Jiannanchun" liquors by aroma extract dilution analysis.
PubMed: Aroma compounds in sweet whey powder.
PubMed: Identification of aroma compounds in Parmigiano-Reggiano cheese by gas chromatography/olfactometry.
PubMed: Characterization of the key aroma compounds in beef extract using aroma extract dilution analysis.
PubMed: Determination of the alkylpyrazine composition of coffee using stable isotope dilution-gas chromatography-mass spectrometry (SIDA-GC-MS).
PubMed: Characterization of cocoa liquors by GC-MS and LC-MS/MS: focus on alkylpyrazines and flavanols.
PubMed: Short communication: Evidence for methylglyoxal-mediated browning of Parmesan cheese during low temperature storage.
PubMed: Alkylpyrazines and other volatiles in cocoa liquors at pH 5 to 8, by Selected Ion Flow Tube-Mass Spectrometry (SIFT-MS).
PubMed: Application of supercritical CO(2) extraction for the elimination of odorant volatile compounds from winemaking inactive dry yeast preparation.
PubMed: Selectivity and efficiency of different reversed-phase and mixed-mode sorbents to preconcentrate and isolate aroma molecules.
PubMed: Syntheses, structures, and photoluminescence of a series of silver(I) sulfonates with pyrazine derivatives.
PubMed: Identification of chemicals emitted by calling males of the Sapote fruit fly, Anastrepha serpentina.
PubMed: Influence of epicatechin reactions on the mechanisms of Maillard product formation in low moisture model systems.
PubMed: Solitary foraging in the ancestral South American ant, Pogonomyrmex vermiculatus. Is it due to constraints in the production or perception of trail pheromones?
PubMed: Degradation of 2,5-dimethylpyrazine by Rhodococcus erythropolis strain DP-45 isolated from a waste gas treatment plant of a fishmeal processing company.
PubMed: Characterization of aroma compounds of chinese "Wuliangye" and "Jiannanchun" liquors by aroma extract dilution analysis.
PubMed: Degradation of 2,3-diethyl-5-methylpyrazine by a newly discovered bacterium, Mycobacterium sp. strain DM-11.
PubMed: Identification of components responsible for the odor of cigar smoker's breath.
PubMed: Determination of the 2H/1H and 15N/14N ratios of Alkylpyrazines from coffee beans (Coffea arabica L. and Coffea canephoravar. robusta) by isotope ratio mass spectrometry.
PubMed: Aroma compounds in sweet whey powder.
PubMed: Pyrazine derivatives in cigarette smoke inhibit hamster oviductal functioning.
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Soluble in:
 water, 1.521e+004 mg/L @ 25 °C (est)
 non-discoloring in most media
 stable in most media
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