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Category:flavoring agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | pale yellow to amber clear liquid (est) |
| Assay: | 97.00 to 100.00
|
| Food Chemicals Codex Listed: | No |
| Specific Gravity: | 1.00300 to 1.00900 @ 25.00 °C.
|
| Pounds per Gallon - (est).: | 8.346 to 8.396
|
| Refractive Index: | 1.51500 to 1.52000 @ 20.00 °C.
|
| Boiling Point: | 100.00 °C. @ 4.00 mm Hg
|
| Vapor Pressure: | 0.010400 mmHg @ 25.00 °C. (est) |
| Flash Point: | 216.00 °F. TCC ( 102.22 °C. )
|
| logP (o/w): | 2.772 (est) |
| Soluble in: |
| | alcohol | | | water, slightly | | | water, 96.61 mg/L @ 25 °C (est) |
| Insoluble in: |
| | water |
Organoleptic Properties:
| Odor Type: nutty |
| green musty nutty |
| Odor Description:at 0.10 % in dipropylene glycol. green musty nutty |
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
gavage-mouse LD50 [sex: M,F] 2673 mg/kg
(Babish, 1978a)
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| Dermal Toxicity: |
|
Not determined
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| Inhalation Toxicity: |
|
Not determined
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Safety in Use Information:
| Category: | | flavoring agents |
| Recommendation for cyclohexyl methyl pyrazine usage levels up to: | | | not for fragrance use.
|
| |
| Maximised Survey-derived Daily Intakes (MSDI-EU): | 0.012 (μg/capita/day) |
| Maximised Survey-derived Daily Intakes (MSDI-USA): | 0.01 (μg/capita/day) |
| Structure Class: | III |
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). |
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library |
| publication number: 12 |
| Click here to view publication 12 |
| | average usual ppm | average maximum ppm |
| baked goods: | - | 1.00000 |
| beverages(nonalcoholic): | - | - |
| beverages(alcoholic): | - | - |
| breakfast cereal: | - | - |
| cheese: | - | - |
| chewing gum: | - | - |
| condiments / relishes: | - | - |
| confectionery froastings: | - | 0.50000 |
| egg products: | - | - |
| fats / oils: | - | - |
| fish products: | - | - |
| frozen dairy: | - | - |
| fruit ices: | - | - |
| gelatins / puddings: | - | 0.50000 |
| granulated sugar: | - | - |
| gravies: | - | - |
| hard candy: | - | - |
| imitation dairy: | - | 0.20000 |
| instant coffee / tea: | - | - |
| jams / jellies: | - | - |
| meat products: | - | - |
| milk products: | - | - |
| nut products: | - | 0.50000 |
| other grains: | - | - |
| poultry: | - | - |
| processed fruits: | - | - |
| processed vegetables: | - | - |
| reconstituted vegetables: | - | - |
| seasonings / flavors: | - | - |
| snack foods: | - | 1.00000 |
| soft candy: | - | 0.50000 |
| soups: | - | - |
| sugar substitutes: | - | - |
| sweet sauces: | - | - |
Safety References:
European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...
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European Food Safety Authority (EFSA) reference(s):
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Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the Commission related to Flavouring Group Evaluation 17 (FGE.17): Pyrazine derivatives from chemical group 24 (Commission Regulation (EC) No 1565/2000 of 18 July 2000)
View page or View pdf
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Flavouring Group Evaluation 50 (FGE.50): Consideration of pyrazine derivatives evaluated by JECFA (57th meeting) structurally related to pyrazine derivatives evaluated by EFSA in FGE.17 (2005) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf
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Flavouring Group Evaluation 17, Revision 1 (FGE.17Rev1): Pyrazine derivatives from chemical group 24 - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) [1]
View page or View pdf
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Scientific Opinion on Flavouring Group Evaluation 17, Revision 2 (FGE.17Rev2): Pyrazine derivatives from chemical group 24
View page or View pdf
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Scientific Opinion on Flavouring Group Evaluation 50, Revision 1 (FGE.50Rev1): Consideration of pyrazine derivatives evaluated by JECFA (57th meeting) structurally related to pyrazine derivatives evaluated by EFSA in FGE.17Rev2 (2010)
View page or View pdf
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| EPI System: View |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA Substance Registry Services (TSCA):28217-92-7 |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :16204532 |
| National Institute of Allergy and Infectious Diseases:Data |
| 2-(cyclohexylmethyl)pyrazine |
| Chemidplus:0028217927 |
References:
Other Information:
Potential Blenders and core components note
| For Odor |
| chocolate |
2,5- dimethyl pyrazine
FL/FR |
| citrus |
methyl heptenone
FL/FR |
| earthy |
(S)-1- octen-3-ol
FL/FR |
| fatty |
hexyl pivalate
FR |
| floral |
amyl benzoate
FL/FR |
cyclamen aldehyde
FL/FR |
| fruity |
tetrahydrofurfuryl butyrate
FL/FR |
| green |
2-sec- butyl-3-methoxypyrazine
FL/FR |
| musty |
2- acetyl pyrrole
FL/FR |
3- acetyl-2,5-dimethyl furan
FL/FR |
menthofuran
FL/FR |
| nutty |
2- acetyl-5-methyl furan
FL/FR |
2,3- dimethyl pyrazine
FL/FR |
4,5- dimethyl-2-ethyl-3-thiazoline
FL/FR |
2- ethyl pyrazine
FL/FR |
2- ethyl-4-methyl thiazole
FL/FR |
filbert pyrazine
FL/FR |
2- methyl pyrazine
FL/FR |
5- methyl quinoxaline
FL/FR |
nutty quinoxaline
FL/FR |
shoyu pyrazine
FL/FR |
2,3,5,6- tetramethyl pyrazine
FL/FR |
2,3,5- trimethyl pyrazine
FL/FR |
vinyl sulfurol
FL/FR |
| waxy |
heptyl octanoate
FL/FR |
octyl 2-methyl butyrate
FL/FR |
| For Flavor |
| No flavor group found for these |
acetyl acetaldehyde dimethyl acetal
FL |
(E)- aconitic acid
FL |
amyl benzoate
FL/FR |
2,5- diethyl thiazole
FL |
2,5- diethyl-4-methyl thiazole
FL |
(S)-1- octen-3-ol
FL/FR |
3- propyl pyridine
FL |
| cocoa |
| cocoa |
butyraldehyde
FL |
| coffee |
2- ethyl-4-methyl thiazole
FL/FR |
2-iso propyl pyrazine
FL |
| fruity |
2,4- hexadien-1-ol
FL |
tetrahydrofurfuryl butyrate
FL/FR |
| green |
cyclamen aldehyde
FL/FR |
methyl heptenone
FL/FR |
4- methyl thiazole
FL |
| musty |
2,5- dimethyl pyrazine
FL/FR |
menthofuran
FL/FR |
shoyu pyrazine
FL/FR |
2,3,5- trimethyl pyrazine
FL/FR |
| nutty |
2- acetyl pyrrole
FL/FR |
3- acetyl-2,5-dimethyl furan
FL/FR |
2- acetyl-5-methyl furan
FL/FR |
2,3- dimethyl pyrazine
FL/FR |
4,5- dimethyl-2-ethyl-3-thiazoline
FL/FR |
2- ethyl pyrazine
FL/FR |
filbert pyrazine
FL/FR |
2- methyl pyrazine
FL/FR |
5- methyl quinoxaline
FL/FR |
nutty quinoxaline
FL/FR |
nutty thiazole
FL |
peanut oxazole
FL |
2,3,5,6- tetramethyl pyrazine
FL/FR |
vinyl sulfurol
FL/FR |
| vegetable |
2-sec- butyl-3-methoxypyrazine
FL/FR |
| waxy |
heptyl octanoate
FL/FR |
octyl 2-methyl butyrate
FL/FR |
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| ( | cyclohexyl methyl) pyrazine | | 2-( | cyclohexyl methyl) pyrazine | | ( | cyclohexylmethyl)pyrazine | | 2-( | cyclohexylmethyl)pyrazine | | 2- | pyrazine cyclohexyl methyl | | | pyrazine, 2-(cyclohexylmethyl)- | | 2- | pyrazinyl cyclohexyl methyl | | 2- | pyrazinyl methyl cyclohexane | | 2- | pyrazinylcyclohexylmethane | | ( | pyrazinylmethyl) cyclohexane | | 2- | pyrazinylmethylcyclohexane |
Articles:
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3D/inchi
