EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

cyclohexyl methyl pyrazine
(cyclohexylmethyl)pyrazine

Supplier Sponsors

Name:2-(cyclohexylmethyl)pyrazine
CAS Number: 28217-92-7Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:248-905-1
FDA UNII:48RW2FS80G
Nikkaji Web:J250.677G
XlogP3:2.90 (est)
Molecular Weight:176.26252000
Formula:C11 H16 N2
NMR Predictor:Predict (works with chrome or firefox)
Category:flavoring agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
JECFA Food Flavoring:783 (cyclohexylmethyl)pyrazine
FLAVIS Number:14.069 (Old)
DG SANTE Food Flavourings:14.069 (cyclohexylmethyl)pyrazine
FEMA Number:3631 (cyclohexylmethyl)pyrazine
FDA:No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm: CYCLOHEXYLMETHYL PYRAZINE
 
Physical Properties:
Appearance:pale yellow to amber clear liquid (est)
Assay: 97.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:1.00300 to 1.00900 @ 25.00 °C.
Pounds per Gallon - (est).: 8.346 to 8.396
Refractive Index:1.51500 to 1.52000 @ 20.00 °C.
Boiling Point: 100.00 °C. @ 4.00 mm Hg
Vapor Pressure:0.010400 mm/Hg @ 25.00 °C. (est)
Flash Point: 216.00 °F. TCC ( 102.22 °C. )
logP (o/w): 2.772 (est)
Soluble in:
 alcohol
 water, slightly
 water, 96.61 mg/L @ 25 °C (est)
Insoluble in:
 water
 
Organoleptic Properties:
Odor Type: nutty
Odor Strength:high ,
recommend smelling in a 0.10 % solution or less
green musty nutty
Odor Description:at 0.10 % in dipropylene glycol. green musty nutty
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Axsyn
For experimental / research use only.
Pyrazine,2-(cyclohexylmethyl)-
BOC Sciences
For experimental / research use only.
(Cyclohexylmethyl)pyrazine
Parchem
cyclohexyl methyl pyrazine
Chemical Sources Association
Need This Item for Flavor/Food?: You can contact the Chemical Sources Association
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
gavage-mouse LD50 [sex: M,F] 2673 mg/kg
(Babish, 1978a)

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: flavoring agents
Recommendation for cyclohexyl methyl pyrazine usage levels up to:
 not for fragrance use.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 0.012 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 0.01 (μg/capita/day)
Structure Class: III
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 12
 average usual ppmaverage maximum ppm
baked goods: -1.00000
beverages(nonalcoholic): --
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: -0.50000
egg products: --
fats / oils: --
fish products: --
frozen dairy: --
fruit ices: --
gelatins / puddings: -0.50000
granulated sugar: --
gravies: --
hard candy: --
imitation dairy: -0.20000
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: -0.50000
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: -1.00000
soft candy: -0.50000
soups: --
sugar substitutes: --
sweet sauces: --
 
Safety References:
European Food Safety Athority(efsa):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the Commission related to Flavouring Group Evaluation 17 (FGE.17): Pyrazine derivatives from chemical group 24 (Commission Regulation (EC) No 1565/2000 of 18 July 2000)
View page or View pdf

Flavouring Group Evaluation 50 (FGE.50): Consideration of pyrazine derivatives evaluated by JECFA (57th meeting) structurally related to pyrazine derivatives evaluated by EFSA in FGE.17 (2005) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf

Flavouring Group Evaluation 17, Revision 1 (FGE.17Rev1): Pyrazine derivatives from chemical group 24 - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) [1]
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 17, Revision 2 (FGE.17Rev2): Pyrazine derivatives from chemical group 24
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 50, Revision 1 (FGE.50Rev1): Consideration of pyrazine derivatives evaluated by JECFA (57th meeting) structurally related to pyrazine derivatives evaluated by EFSA in FGE.17Rev2 (2010)
View page or View pdf

EPI System: View
EPA Substance Registry Services (TSCA):28217-92-7
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :16204532
National Institute of Allergy and Infectious Diseases:Data
2-(cyclohexylmethyl)pyrazine
Chemidplus:0028217927
 
References:
 2-(cyclohexylmethyl)pyrazine
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:28217-92-7
Pubchem (cid):16204532
Pubchem (sid):135264457
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS):View
HMDB (The Human Metabolome Database):HMDB36175
FooDB:FDB015029
ChemSpider:View
 
Potential Blenders and core components note
For Odor
chocolate
2,5-
dimethyl pyrazine
FL/FR
citrus
methyl heptenone
FL/FR
earthy
(S)-1-
octen-3-ol
FL/FR
fatty
hexyl pivalate
FR
floral
amyl benzoate
FL/FR
cyclamen aldehyde
FL/FR
fruity
tetrahydrofurfuryl butyrate
FL/FR
green
2-sec-
butyl-3-methoxypyrazine
FL/FR
musty
2-
acetyl pyrrole
FL/FR
3-
acetyl-2,5-dimethyl furan
FL/FR
menthofuran
FL/FR
nutty
2-
acetyl-5-methyl furan
FL/FR
2,3-
dimethyl pyrazine
FL/FR
4,5-
dimethyl-2-ethyl-3-thiazoline
FL/FR
2-
ethyl pyrazine
FL/FR
2-
ethyl-4-methyl thiazole
FL/FR
filbert pyrazine
FL/FR
2-
methyl pyrazine
FL/FR
5-
methyl quinoxaline
FL/FR
nutty quinoxaline
FL/FR
shoyu pyrazine
FL/FR
2,3,5,6-
tetramethyl pyrazine
FL/FR
2,3,5-
trimethyl pyrazine
FL/FR
vinyl sulfurol
FL/FR
waxy
heptyl octanoate
FL/FR
octyl 2-methyl butyrate
FL/FR
For Flavor
No flavor group found for these
acetyl acetaldehyde dimethyl acetal
FL
(E)-
aconitic acid
FL
amyl benzoate
FL/FR
2,5-
diethyl thiazole
FL
2,5-
diethyl-4-methyl thiazole
FL
(S)-1-
octen-3-ol
FL/FR
3-
propyl pyridine
FL
cocoa
cocoa
butyraldehyde
FL
coffee
2-
ethyl-4-methyl thiazole
FL/FR
2-iso
propyl pyrazine
FL
fruity
2,4-
hexadien-1-ol
FL
tetrahydrofurfuryl butyrate
FL/FR
green
cyclamen aldehyde
FL/FR
methyl heptenone
FL/FR
4-
methyl thiazole
FL
musty
2,5-
dimethyl pyrazine
FL/FR
menthofuran
FL/FR
shoyu pyrazine
FL/FR
2,3,5-
trimethyl pyrazine
FL/FR
nutty
2-
acetyl pyrrole
FL/FR
3-
acetyl-2,5-dimethyl furan
FL/FR
2-
acetyl-5-methyl furan
FL/FR
2,3-
dimethyl pyrazine
FL/FR
4,5-
dimethyl-2-ethyl-3-thiazoline
FL/FR
2-
ethyl pyrazine
FL/FR
filbert pyrazine
FL/FR
2-
methyl pyrazine
FL/FR
5-
methyl quinoxaline
FL/FR
nutty quinoxaline
FL/FR
nutty thiazole
FL
peanut oxazole
FL
2,3,5,6-
tetramethyl pyrazine
FL/FR
vinyl sulfurol
FL/FR
vegetable
2-sec-
butyl-3-methoxypyrazine
FL/FR
waxy
heptyl octanoate
FL/FR
octyl 2-methyl butyrate
FL/FR
 
Potential Uses:
FLgreen
FLnut
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
(cyclohexyl methyl) pyrazine
2-(cyclohexyl methyl) pyrazine
(cyclohexylmethyl)pyrazine
2-(cyclohexylmethyl)pyrazine
2-pyrazine cyclohexyl methyl
 pyrazine, 2-(cyclohexylmethyl)-
2-pyrazinyl cyclohexyl methyl
2-pyrazinyl methyl cyclohexane
2-pyrazinylcyclohexylmethane
(pyrazinylmethyl) cyclohexane
2-pyrazinylmethylcyclohexane
 
 
Notes:
Flavouring ingredient. Possesses fungicidal and acaricidal activity. No commercial useage in agriculture
Please share your Comments.
Email Address:
Top of Page Home
Copyright © 1980-2018 The Good Scents Company (tgsc) ™ Disclaimer Privacy Policy