EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

ortho-methyl anisole
o-methylanisole

Supplier Sponsors

Name:1-methoxy-2-methylbenzene
CAS Number: 578-58-5Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:209-426-3
FDA UNII:09G73SL17K
Nikkaji Web:J7.427F
MDL:MFCD00008373
CoE Number:187
XlogP3:2.70 (est)
Molecular Weight:122.16690000
Formula:C8 H10 O
NMR Predictor:Predict (works with chrome or firefox)
Category:flavor and fragrance agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
JECFA Food Flavoring:1242 o-methylanisole
FLAVIS Number:04.014 (Old)
DG SANTE Food Flavourings:04.014 1-methoxy-2-methylbenzene
FEMA Number:2680 o-methylanisole
FDA:No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF):578-58-5 ; O-METHYLANISOLE
FDA Regulation:
FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION
Subpart F--Flavoring Agents and Related Substances
Sec. 172.515 Synthetic flavoring substances and adjuvants.
 
Physical Properties:
Appearance:colorless clear liquid (est)
Assay: 99.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:0.97900 to 0.98200 @ 20.00 °C.
Pounds per Gallon - (est).: 8.156 to 8.181
Refractive Index:1.51500 to 1.51800 @ 20.00 °C.
Melting Point: -34.10 °C. @ 760.00 mm Hg
Boiling Point: 170.00 to 172.00 °C. @ 760.00 mm Hg
Boiling Point: 63.00 to 64.00 °C. @ 14.00 mm Hg
Vapor Pressure:1.900000 mmHg @ 25.00 °C. (est)
Flash Point: 125.00 °F. TCC ( 51.67 °C. )
logP (o/w): 2.740
Soluble in:
 alcohol
 water, 450.4 mg/L @ 25 °C (est)
Insoluble in:
 water
 
Organoleptic Properties:
Odor Type: naphthyl
Odor Strength:medium ,
recommend smelling in a 1.00 % solution or less
sweet nutty floral earthy walnut
Odor Description:at 1.00 % in dipropylene glycol. sweet nutty floral earthy walnut
naphthyl camphoreous phenolic woody orchid
Odor Description:at 1.00 %. Naphthyl, camphoreous, phenolic and woody with a salicylate nuance
Mosciano, Gerard P&F 23, No. 3, 55, (1998)
Flavor Type: camphoreous
camphoreous earthy woody orchid minty spicy
Taste Description: at 5.00 ppm. Camphoreous, earthy, woody and salicylate with minty, spicy nuances
Mosciano, Gerard P&F 23, No. 3, 55, (1998)
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
2-Methylanisole
EMD Millipore
For experimental / research use only.
2-Methylanisole
Penta International
2-METHYL ANISOLE NATURAL
Penta International
2-METHYL ANISOLE
Santa Cruz Biotechnology
For experimental / research use only.
2-Methylanisole
Sigma-Aldrich
2-Methylanisole, ≥99%, FG
Odor: earthy; floral; walnut
Certified Food Grade Products
Synerzine
o-Methylanisole
TCI AMERICA
For experimental / research use only.
2-Methoxytoluene >98.0%(GC)
 
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
Xi - Irritant
R 10 - Flammable.
R 38 - Irritating to skin.
S 02 - Keep out of the reach of children.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36 - Wear suitable protective clothing.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: flavor and fragrance agents
Recommendation for ortho-methyl anisole usage levels up to:
  2.0000 % in the fragrance concentrate.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 2.40 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 0.06 (μg/capita/day)
Structure Class: I
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
 average usual ppmaverage maximum ppm
baked goods: -4.00000
beverages(nonalcoholic): -1.70000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: -1.00000
fruit ices: -1.00000
gelatins / puddings: --
granulated sugar: --
gravies: --
hard candy: 2.300004.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --
 
Safety References:
European Food Safety Athority(efsa):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Flavouring Group Evaluation 23 (FGE.23): Aliphatic, alicyclic and aromatic ethers including anisole derivatives From chemical groups 15, 16 and 26 (Commission Regulation (EC) No 1565/2000 of 18 July 2000
View page or View pdf

Flavouring Group Evaluation 59 (FGE.59): Consideration of aliphatic and aromatic ethers evaluated by JECFA (61st meeting) structurally related to aliphatic, alicyclic and aromatic ethers including anisole derivatives evaluated by EFSA in FGE.23 (2006) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf

Flavouring Group Evaluation 23, Revision 1 (FGE.23Rev1): Aliphatic, alicyclic and aromatic ethers including anisole derivatives from chemical groups 15, 16, 26 and 30[1] - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 59, Revision 1 (FGE.59Rev1): Consideration of aliphatic and aromatic ethers evaluated by JECFA (61st meeting and 63rd meeting) structurally related to aliphatic, alicyclic and aromatic ethers including anisole derivatives evaluated by EFSA in FGE.23 Rev2 (2010)
View page or View pdf

EPI System: View
Cancer Citations:Search
EPA Substance Registry Services (TSCA):578-58-5
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :33637
National Institute of Allergy and Infectious Diseases:Data
WISER:UN 1993
WGK Germany:3
1-methoxy-2-methylbenzene
Chemidplus:0000578585
 
References:
 1-methoxy-2-methylbenzene
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:578-58-5
Pubchem (cid):33637
Pubchem (sid):135017865
Flavornet:578-58-5
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
HMDB (The Human Metabolome Database):HMDB32074
FooDB:FDB008787
Export Tariff Code:3909.30
Haz-Map:View
Typical G.C.
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
RSC Learn Chemistry:View
 
Potential Blenders and core components note
For Odor
No odor group found for these
sulfuryl octanoate
FL/FR
sulfuryl butyrate
FL/FR
sulfuryl decanoate
FL/FR
sulfuryl hexanoate
FL/FR
sulfuryl isobutyrate
FL/FR
sulfuryl propionate
FL/FR
valeraldehyde dibutyl acetal
FL/FR
valeraldehyde propylene glycol acetal
FL/FR
balsamic
balsamic
propyl benzoate
FL/FR
bready
coffee furanone
FL/FR
buttery
acetyl propionyl
FL/FR
3,4-
hexane dione
FL/FR
camphoreous
bornyl isobutyrate
FL/FR
butyrophenone
FL/FR
caramellic
ethyl 2-hydroxy-2-methyl butyrate
FL/FR
chocolate
chocolate pyrazine A
FL/FR
2,5-
dimethyl pyrazine
FL/FR
2-
methoxypyrazine
FL/FR
2-
methyl butyraldehyde
FL/FR
coconut
alpha-
angelica lactone
FL/FR
gamma-
heptalactone
FL/FR
corn chip
popcorn pyrimidine
FL/FR
coumarinic
coumane
FL/FR
tonka bean resinoid
FR
earthy
2-
ethyl-3-methoxypyrazine
FL/FR
(Z)-
linalool oxide (furanoid)
FL/FR
2-
octanone oxime
FR
fatty
coconut absolute
FL/FR
fermented
valeraldehyde
FL/FR
floral
bois de rose oil terpeneless
FL/FR
boronia butenal
FR
para-
cresyl laurate
FL/FR
geranium oil morocco
FL/FR
hawthorn carbinol
FL/FR
2-
methyl-4-phenyl butanal
FL/FR
phenyl acetaldehyde 2,3-butylene glycol acetal
FL/FR
2-
phenyl propionaldehyde dimethyl acetal
FL/FR
(R)-
styralyl alcohol
FL/FR
fruity
allyl 2-ethyl butyrate
FL/FR
iso
amyl nonanoate
FL/FR
methyl valerate
FL/FR
3-
methyl-2-butenal
FL/FR
styralyl butyrate
FL/FR
tropical thiazole
FL/FR
green
alpha,alpha-
dimethyl benzyl alcohol
FL/FR
earthy acetal
FL/FR
2-
heptyl furan
FL/FR
lilac acetaldehyde
FL/FR
methyl cyclocitrone (IFF)
FR
(E,Z)-2,6-
nonadien-1-yl acetate
FL/FR
3,5,5-
trimethyl hexanol
FL/FR
herbal
dehydroxylinalool oxide
FL/FR
2,10-
epoxypinane
FR
saffron pyranone
FR
minty
dextro-
carvone
FL/FR
dextro-
dihydrocarvone
FL/FR
methyl salicylate
FL/FR
mossy
oakmoss absolute
FL/FR
musty
2-
acetyl pyrrole
FL/FR
3-
acetyl-2,5-dimethyl furan
FL/FR
hazelnut pyrazine
FL/FR
menthofuran
FL/FR
naphthyl
para-
methyl anisole
FL/FR
nutty
3-
acetyl pyridine
FL/FR
2-
acetyl-3-ethyl pyrazine
FL/FR
2-
acetyl-3-methyl pyrazine
FL/FR
2-
acetyl-3,5-dimethyl pyrazine
FL/FR
2-
acetyl-5-methyl furan
FL/FR
3,6-
cocoa pyrazine
FL/FR
3,5-
cocoa pyrazine
FL/FR
2,3-
dimethyl pyrazine
FL/FR
4,5-
dimethyl-2-ethyl-3-thiazoline
FL/FR
2-
ethyl pyrazine
FL/FR
2-
ethyl-4-methyl thiazole
FL/FR
filbert heptenone
FL/FR
filbert pyrazine
FL/FR
2,6-
lutidine
FL/FR
maraniol
CS
2-
methyl pyrazine
FL/FR
5-
methyl quinoxaline
FL/FR
2-
methyl thio-3,5 or 6-methyl pyrazine
FL/FR
2-
methyl-3-(methyl thio) pyrazine
FL/FR
2-
methyl-3-ethoxypyrazine
FL/FR
2-
methyl-3-propyl pyrazine
FL/FR
nutty cyclohexenone
FL/FR
nutty quinoxaline
FL/FR
ortho-
salicylic acid
CS
shoyu pyrazine
FL/FR
2,3,5,6-
tetramethyl pyrazine
FL/FR
2,3,5-
trimethyl pyrazine
FL/FR
vinyl sulfurol
FL/FR
popcorn
2-
acetyl pyrazine
FL/FR
2-
acetyl thiazole
FL/FR
spicy
carvacrol
FL/FR
4-
carvomenthenol
FL/FR
3-(2-
furyl) acrolein
FL/FR
origanum majorana oil
FL/FR
sulfurous
benzothiazole
FL/FR
furfuryl thioacetate
FL/FR
tobacco
veltonal (Bedoukian)
FR
tonka
coumarin
FR
tonka bean absolute
FR
whiskey lactone
FL/FR
woody
dryopteris filix-mas oleoresin
FR
sandalwood oil
FL/FR
For Flavor
No flavor group found for these
acetyl acetaldehyde dimethyl acetal
FL
bornyl isobutyrate
FL/FR
butyrophenone
FL/FR
chocolate pyrazine A
FL/FR
chocolate pyrazine B
FL
coumane
FL/FR
cyclohexyl methyl pyrazine
FL
2,5-
diethyl thiazole
FL
2,5-
diethyl-4-methyl thiazole
FL
6,7-
dihydro-2,3-dimethyl-5H-cyclopentapyrazine
FL
alpha,alpha-
dimethyl benzyl alcohol
FL/FR
dimethyl dihydrocyclopentapyrazine
FL
2,5-
dimethyl thiazole
FL
earthy acetal
FL/FR
ethyl 2-hydroxy-2-methyl butyrate
FL/FR
2-
ethyl-3-methoxypyrazine
FL/FR
(Z+E)-5-
ethyl-4-methyl-2-(2-butyl) thiazoline
FL
(Z+E)-5-
ethyl-4-methyl-2-(2-methyl propyl) thiazoline
FL
3-(2-
furyl) acrolein
FL/FR
(E,E)-2,4-
heptadien-1-ol
FL
2-
hexyl-5 or 6-keto-1,4-dioxane
FL
(Z)-
linalool oxide (furanoid)
FL/FR
2-
methoxypyrazine
FL/FR
methyl 2-(methyl thio) acetate
FL
2-
methyl-3-(methyl thio) pyrazine
FL/FR
2-
methyl-3-ethoxypyrazine
FL/FR
2-
methyl-4-phenyl butanal
FL/FR
peanut dithiazine
FL
phenyl acetaldehyde 2,3-butylene glycol acetal
FL/FR
2-
propyl pyridine
FL
para-
salicylic acid
FL
(R)-
styralyl alcohol
FL/FR
sulfuryl butyrate
FL/FR
sulfuryl decanoate
FL/FR
sulfuryl hexanoate
FL/FR
sulfuryl isobutyrate
FL/FR
valeraldehyde propylene glycol acetal
FL/FR
5-
acetyl-2,3-dihydro-1,4-thiazine
FL
sulfuryl formate
FL
sulfuryl octanoate
FL/FR
sulfuryl propionate
FL/FR
valeraldehyde dibutyl acetal
FL/FR
alliaceous
alliaceous
2-
methyl thioacetaldehyde
FL
tropical thiazole
FL/FR
bready
2-
propionyl thiazole
FL
burnt
2-
methyl quinoxaline
FL
buttery
3,4-
hexane dione
FL/FR
coffee
difurfuryl ether
FL
2-
ethyl-4-methyl thiazole
FL/FR
2-iso
propyl pyrazine
FL
cooling
4-
carvomenthenol
FL/FR
corn chip
2-
acetyl thiazole
FL/FR
2-
acetyl-2-thiazoline
FL
popcorn pyrimidine
FL/FR
creamy
alpha-
angelica lactone
FL/FR
earthy
2-
methyl-3-propyl pyrazine
FL/FR
ethereal
allyl 2-ethyl butyrate
FL/FR
fatty
coconut absolute
FL/FR
(E,E)-2,4-
decadienal
FL
2-
heptyl furan
FL/FR
(E,E)-2,4-
nonadienal
FL
fishy
4,5-
dimethyl thiazole
FL
floral
bois de rose oil terpeneless
FL/FR
geranium oil morocco
FL/FR
fruity
2,4-
hexadien-1-ol
FL
lilac acetaldehyde
FL/FR
methyl valerate
FL/FR
3-
methyl-2-butenal
FL/FR
2-
phenyl propionaldehyde dimethyl acetal
FL/FR
propyl benzoate
FL/FR
styralyl butyrate
FL/FR
fusel
2-
methyl butyraldehyde
FL/FR
green
dextro-
dihydrocarvone
FL/FR
dihydroxyacetophenone (mixed isomers)
FL
2,5-
dimethyl thiophene
FL
4-
methyl thiazole
FL
2-
methyl-5-isopropyl pyrazine
FL
(E,Z)-2,6-
nonadien-1-yl acetate
FL/FR
oakmoss absolute
FL/FR
3,5,5-
trimethyl hexanol
FL/FR
2-
vinyl pyrazine
FL
herbal
origanum majorana oil
FL/FR
lactonic
gamma-
heptalactone
FL/FR
meaty
benzothiazole
FL/FR
minty
dextro-
carvone
FL/FR
methyl salicylate
FL/FR
musty
2,5-
dimethyl pyrazine
FL/FR
2-
ethoxythiazole
FL
hazelnut pyrazine
FL/FR
menthofuran
FL/FR
propionaldehyde
FL
shoyu pyrazine
FL/FR
2,3,5-
trimethyl pyrazine
FL/FR
naphthyl
para-
methyl anisole
FL/FR
nutty
3-
acetyl pyridine
FL/FR
2-
acetyl pyrrole
FL/FR
3-
acetyl-2,5-dimethyl furan
FL/FR
2-
acetyl-3-ethyl pyrazine
FL/FR
2-
acetyl-3-methyl pyrazine
FL/FR
2-
acetyl-3,5-dimethyl pyrazine
FL/FR
2-
acetyl-5-methyl furan
FL/FR
3,5-
cocoa pyrazine
FL/FR
3,6-
cocoa pyrazine
FL/FR
coffee furanone
FL/FR
3,5-
diethyl-2-methyl pyrazine
FL
2,5-
diethyl-3-methyl pyrazine
FL
2,3-
dimethyl pyrazine
FL/FR
4,5-
dimethyl-2-ethyl-3-thiazoline
FL/FR
2,4-
dimethyl-5-vinyl thiazole
FL
2-
ethyl pyrazine
FL/FR
1-
ethyl-2-acetyl pyrrole
FL
filbert heptenone
FL/FR
filbert pyrazine
FL/FR
european
hazelnut oleoresin
FL
2,6-
lutidine
FL/FR
2-
methyl pyrazine
FL/FR
5-
methyl quinoxaline
FL/FR
2-
methyl thio-3,5 or 6-methyl pyrazine
FL/FR
nutty cyclohexenone
FL/FR
nutty quinoxaline
FL/FR
nutty thiazole
FL
peanut oxazole
FL
2,3,5,6-
tetramethyl pyrazine
FL/FR
vinyl sulfurol
FL/FR
popcorn
2-
propionyl-2-thiazoline
FL
roasted
2-
acetyl pyrazine
FL/FR
furfuryl thioacetate
FL/FR
spicy
carvacrol
FL/FR
hawthorn carbinol
FL/FR
toasted
acetyl propionyl
FL/FR
waxy
para-
cresyl laurate
FL/FR
winey
iso
amyl nonanoate
FL/FR
5-
ethyl-2-methyl pyridine
FL
valeraldehyde
FL/FR
woody
dehydroxylinalool oxide
FL/FR
sandalwood oil
FL/FR
whiskey lactone
FL/FR
yerba mate concentrate
FL
 
Potential Uses:
FLbread
FRcherry
FRcoffee
FRearth
FRfilbert
FRhazelnut
FRherbal
FRvanilla
FLwalnut
 
Occurrence (nature, food, other):note
 cascarilla bark oil @ 0.02%
Data GC Search Trop Picture
 clam
Search PMC Picture
 coffee
Search PMC Picture
 filbert
Search Trop Picture
 katsuobushi
Search PMC Picture
 maize
Search PMC Picture
 rice wild rice
Search PMC Picture
 rue oil china @ 0.02%
Data GC Search Trop Picture
 tea rooibos tea
Search Trop Picture
 
Synonyms:
 anisole, 2-methyl-
 benzene, 1-methoxy-2-methyl-
o-cresyl methyl ether
ortho-cresyl methyl ether
1-methoxy-2-methyl benzene
1-methoxy-2-methylbenzene
2-methoxytoluene
o-methoxytoluene
ortho-methoxytoluene
 methyl 2-methylphenyl ether
2-methyl anisole
o-methyl anisole
2-methyl anisole natural
2-methyl methoxybenzene
 methyl o-tolyl ether
 methyl ortho-cresyl ether
2-methyl ortho-tolyl ether
2-methylanisole
o-methylanisole
ortho-methylanisole
 
 
Notes:
Flavouring ingredient
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