EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

ortho-acetanisole
2-methoxyacetophenone

Sponsors

Name:1-(2-methoxyphenyl)ethanone
CAS Number: 579-74-8Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:209-446-2
FDA UNII:0WYN389I4N
Nikkaji Web:J150.134H
Beilstein Number:1100602
MDL:MFCD00008725
XlogP3:1.80 (est)
Molecular Weight:150.17710000
Formula:C9 H10 O2
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:flavor and fragrance agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
JECFA Food Flavoring:2042 2-methoxyacetophenone
FLAVIS Number:07.254 (Old)
DG SANTE Food Flavourings:07.254 2-methoxyacetophenone
FEMA Number:4163 2-methoxyacetophenone
FDA:No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm: 2-METHOXYACETOPHENONE
 
Physical Properties:
Appearance:colorless to pale yellow clear liquid (est)
Assay: 99.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:1.08900 to 1.09200 @ 25.00 °C.
Pounds per Gallon - (est).: 9.062 to 9.087
Specific Gravity:1.08800 to 1.09200 @ 20.00 °C.
Pounds per Gallon - est.: 9.064 to 9.097
Refractive Index:1.54000 @ 20.00 °C.
Refractive Index:1.53700 to 1.54200 @ 20.00 °C.
Boiling Point: 245.00 to 248.00 °C. @ 760.00 mm Hg
Vapor Pressure:0.029000 mm/Hg @ 25.00 °C.
Flash Point: 228.00 °F. TCC ( 108.89 °C. )
logP (o/w): 1.820
Soluble in:
 alcohol
 propylene glycol
 water, 2114 mg/L @ 25 °C (est)
Insoluble in:
 water
Similar Items:note
meta-acetanisole
para-acetanisole
 
Organoleptic Properties:
Odor Type: anisic
Odor Strength:medium ,
recommend smelling in a 1.00 % solution or less
Substantivity:6 hour(s) at 100.00 %
powdery anisic almond phenolic
Odor Description:at 1.00 % in propylene glycol. powdery anisic almond phenolic
Luebke, William tgsc, (2006)
Odor sample from: Sigma-Aldrich
Flavor Type: powdery
powdery musty anisic almond cherry maraschino cherry
Taste Description: at 30.00 ppm in water. powdery musty anisic almond
Luebke, William tgsc, (2006)
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
2'-Methoxyacetophenone
EMD Millipore
For experimental / research use only.
2'-Methoxyacetophenone
Jalor-Chem
For experimental / research use only.
2'-Methoxyacetophenone
Parchem
ortho-acetanisole
Penta International
2-METHOXYACETOPHENONE, Kosher
Santa Cruz Biotechnology
For experimental / research use only.
2'-Methoxyacetophenone
Sigma-Aldrich: Aldrich
For experimental / research use only.
2'-Methoxyacetophenone 99%
TCI AMERICA
For experimental / research use only.
2'-Methoxyacetophenone >97.0%(GC)
 
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
Xn - Harmful.
R 22 - Harmful if swallowed.
S 02 - Keep out of the reach of children.
S 20 - When using do not eat or drink.
S 37/39 - Wear suitable gloves and eye/face protection.
S 46 - If swallowed, seek medical advice immediately and show this container or label.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: flavor and fragrance agents
Recommendation for ortho-acetanisole usage levels up to:
  1.0000 % in the fragrance concentrate.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 0.37 (μg/capita/day)
Modified Theoretical Added Maximum Daily Intake (mTAMDI): 2100 (μg/person/day)
Threshold of Concern:1800 (μg/person/day)
Structure Class: I
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 22
 average usual ppmaverage maximum ppm
baked goods: 10.0000050.00000
beverages(nonalcoholic): 1.0000010.00000
beverages(alcoholic): 3.0000030.00000
breakfast cereal: --
cheese: --
chewing gum: 30.0000050.00000
condiments / relishes: --
confectionery froastings: 5.0000020.00000
egg products: --
fats / oils: --
fish products: --
frozen dairy: 5.0000020.00000
fruit ices: 1.0000010.00000
gelatins / puddings: --
granulated sugar: --
gravies: --
hard candy: 10.0000020.00000
imitation dairy: --
instant coffee / tea: 5.0000050.00000
jams / jellies: 1.0000010.00000
meat products: --
milk products: 5.0000020.00000
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: 5.0000020.00000
soups: --
sugar substitutes: --
sweet sauces: --
 
Food categories according to Commission Regulation EC No. 1565/2000 (EC, 2000) in FGE.06 (EFSA, 2002a). According to the Industry the "normal" use is defined as the average of reported usages and "maximum use" is defined as the 95th percentile of reported usages (EFSA, 2002i).
Note: mg/kg = 0.001/1000 = 0.000001 = 1/1000000 = ppm.
 average usage mg/kgmaximum usage mg/kg
Dairy products, excluding products of category 02.0 (01.0): 5.0000020.00000
Fats and oils, and fat emulsions (type water-in-oil) (02.0): 10.0000020.00000
Edible ices, including sherbet and sorbet (03.0): 1.0000010.00000
Processed fruit (04.1): --
Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2): --
Confectionery (05.0): 5.0000020.00000
Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0): --
Bakery wares (07.0): 10.0000050.00000
Meat and meat products, including poultry and game (08.0): --
Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0): --
Eggs and egg products (10.0): --
Sweeteners, including honey (11.0): --
Salts, spices, soups, sauces, salads, protein products, etc. (12.0): 1.0000010.00000
Foodstuffs intended for particular nutritional uses (13.0): --
Non-alcoholic ("soft") beverages, excl. dairy products (14.1): 1.0000010.00000
Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2): 3.0000030.00000
Ready-to-eat savouries (15.0): 10.0000020.00000
Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0): --
 
Safety References:
European Food Safety Athority(efsa):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Flavouring Group Evaluation 16, Revision 1 (FGE.16Rev1)[1]: Aromatic ketones from chemical group 21- Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food
View page or View pdf

Flavouring Group Evaluation 16, Revision 2 (FGE.16Rev2): Aromatic ketones from chemical group 21
View page or View pdf

EPI System: View
EPA Substance Registry Services (TSCA):579-74-8
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :68481
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
1-(2-methoxyphenyl)ethanone
Chemidplus:0000579748
 
References:
 1-(2-methoxyphenyl)ethanone
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:579-74-8
Pubchem (cid):68481
Pubchem (sid):135026464
Pherobase:View
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS):View
HMDB (The Human Metabolome Database):HMDB32569
FooDB:FDB010501
Export Tariff Code:2914.50.2000
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
FAO:2-Methoxyacetophenone
 
Potential Blenders and core components note
For Odor
acidic
cyclohexyl acetic acid
FL/FR
anisic
para-
acetanisole
FL/FR
ambrette seed oil
FL/FR
para-
anisaldehyde
FL/FR
ortho-
anisaldehyde
FL/FR
sassafras acetate
FL/FR
balsamic
2-
acetyl furan
FL/FR
benzophenone
FR
iso
butyl benzoate
FL/FR
(E)-
cinnamyl alcohol
FL/FR
cinnamyl alcohol
FL/FR
ethyl cinnamate
FL/FR
peru balsam oil
FL/FR
bready
furfural
FL/FR
buttery
3,4-
hexane dione
FL/FR
caramellic
geranyl crotonate
FR
chocolate
chocolate pyrazine A
FL/FR
cocoa oleoresin
FL/FR
cocoa pentenal
FL/FR
2-
methoxy-3-methyl pyrazine
FL/FR
coumarinic
phthalide
FL/FR
creamy
para-
vanillic acid
FL/FR
floral
acetophenone
FL/FR
para-
anisaldehyde / methyl anthranilate schiff's base
FR
para-
anisyl acetaldehyde
FL/FR
anisyl propanal / methyl anthranilate schiff's base
FR
dimethyl alpha-ionone
FR
dimethyl anthranilate
FL/FR
geranyl phenyl acetate
FL/FR
heliotropin
FL/FR
(E)-beta-
ionone
FL/FR
alpha-
irone
FL/FR
ortho-
methyl acetophenone
FL/FR
beta-iso
methyl ionone
FL/FR
alpha-iso
methyl ionone (50% min.)
FL/FR
alpha-iso
methyl ionone (90% min.)
FL/FR
methyl ionyl acetate
FL/FR
orris rhizome resinoid (iris pallida)
FL/FR
phenyl acetaldehyde diisobutyl acetal
FL/FR
iso
propyl phenyl acetate
FL/FR
rhodinol
FL/FR
rhodinyl phenyl acetate
FL/FR
(E)-2,5,9-
trimethyl-4,9-decadien-1-al
FR
fruity
acetyl methyl anthranilate
FL/FR
bitter
almond oil
FL/FR
para-
anisyl methyl ketone
FL/FR
benzaldehyde
FL/FR
benzaldehyde / methyl anthranilate schiff's base
FR
benzaldehyde glycrol acetal
FL/FR
2-
benzofuran carboxaldehyde
FL/FR
berry hexanoate
FR
bread thiophene
FL/FR
cherry oxyacetate
FL/FR
cyclohexyl cinnamate
FL/FR
4-
ethyl benzaldehyde
FL/FR
ethyl methyl-para-tolyl glycidate
FL/FR
3-
methyl-2-butenal
FL/FR
peach pivalate
FR
tolualdehyde glyceryl acetal
FL/FR
tolualdehydes (mixed o,m,p)
FL/FR
green
benzaldehyde dimethyl acetal
FL/FR
para-
methyl hydratropaldehyde
FL/FR
phenoxyethyl isobutyrate
FL/FR
phenyl acetaldehyde diethyl acetal
FL/FR
tiglaldehyde
FL/FR
herbal
american
elder flower absolute
FR
floral nitrile
FR
honey
methyl phenyl acetate
FL/FR
phenyl pyruvic acid
FL/FR
musk
cyclohexadecanone
FR
ethylene brassylate
FL/FR
exaltone (Firmenich)
FR
dextro,laevo-
muscone
FL/FR
musk amberol
FR
musk indane
FR
musk tetralin
FR
omega-
pentadecalactone
FL/FR
musty
cocoa butenal
FL/FR
naphthyl
2,4-
dimethyl benzaldehyde
FL/FR
para-
methyl anisole
FL/FR
beta-
naphthyl ethyl ether
FL/FR
nutty
3,5-
cocoa pyrazine
FL/FR
2-
methyl-3-(methyl thio) pyrazine
FL/FR
2-
methyl-3-ethoxypyrazine
FL/FR
2,3,5-
trimethyl pyrazine
FL/FR
phenolic
methyl benzoate
FL/FR
powdery
para-
anisyl acetate
FL/FR
para-
anisyl alcohol
FL/FR
dibenzyl ketone
FL/FR
alpha-
methyl ionone
FL/FR
tonka
mint lactone
FL/FR
vanilla
heliotropyl alcohol
FL/FR
vanillyl acetate
FL/FR
vanillylidene acetone
FL/FR
woody
amber formate
FR
guaiacwood oil
FL/FR
patchouli ethanone
FR
(+)-alpha-
santalyl acetate
FL/FR
timber propanol
FR
vetiveryl acetate
FL/FR
woody epoxide
FR
For Flavor
No flavor group found for these
ambrette seed oil
FL/FR
para-
anisyl acetaldehyde
FL/FR
chocolate pyrazine A
FL/FR
(E)-
cinnamyl alcohol
FL/FR
cyclohexyl cinnamate
FL/FR
4-
ethyl benzaldehyde
FL/FR
5-
ethyl-2-thiophene carboxaldehyde
FL
heliotropyl alcohol
FL/FR
2-
hexenal
FL
beta-iso
methyl ionone
FL/FR
4-
methyl salicylaldehyde
FL
2-
methyl-3-(methyl thio) pyrazine
FL/FR
2-
methyl-3-ethoxypyrazine
FL/FR
peru balsam
FL
phenyl acetaldehyde diethyl acetal
FL/FR
(+)-alpha-
santalyl acetate
FL/FR
tolualdehyde glyceryl acetal
FL/FR
vetiveryl acetate
FL/FR
anisic
anisic
para-
acetanisole
FL/FR
ortho-
anisaldehyde
FL/FR
ortho-
methyl acetophenone
FL/FR
balsamic
ethyl cinnamate
FL/FR
peru balsam oil
FL/FR
vanillylidene acetone
FL/FR
bitter
dibenzyl ketone
FL/FR
brown
furfural
FL/FR
buttery
3,4-
hexane dione
FL/FR
cherry
heliotropin
FL/FR
chocolate
cocoa oleoresin
FL/FR
coconut
6-
methyl coumarin
FL
coumarinic
phthalide
FL/FR
creamy
para-
anisaldehyde
FL/FR
mint lactone
FL/FR
para-
vanillic acid
FL/FR
floral
cocoa pentenal
FL/FR
geranyl phenyl acetate
FL/FR
alpha-iso
methyl ionone (50% min.)
FL/FR
alpha-iso
methyl ionone (90% min.)
FL/FR
methyl phenyl acetate
FL/FR
orris rhizome resinoid (iris pallida)
FL/FR
rhodinol
FL/FR
fruity
acetyl methyl anthranilate
FL/FR
bitter
almond oil
FL/FR
para-
anisyl acetate
FL/FR
para-
anisyl alcohol
FL/FR
benzaldehyde
FL/FR
benzaldehyde glycrol acetal
FL/FR
bread thiophene
FL/FR
iso
butyl benzoate
FL/FR
cherry laurel oil
FL
cherry oxyacetate
FL/FR
dimethyl anthranilate
FL/FR
ethyl methyl-para-tolyl glycidate
FL/FR
2,4-
hexadien-1-ol
FL
alpha-
methyl ionone
FL/FR
3-
methyl-2-butenal
FL/FR
tiglaldehyde
FL/FR
tolualdehydes (mixed o,m,p)
FL/FR
green
benzaldehyde dimethyl acetal
FL/FR
cinnamyl alcohol
FL/FR
cocoa butenal
FL/FR
para-
methyl hydratropaldehyde
FL/FR
phenoxyethyl isobutyrate
FL/FR
phenyl acetaldehyde diisobutyl acetal
FL/FR
honey
iso
propyl phenyl acetate
FL/FR
meaty
ortho-
thioguaiacol
FL
musk
ethylene brassylate
FL/FR
dextro,laevo-
muscone
FL/FR
musty
2,3,5-
trimethyl pyrazine
FL/FR
naphthyl
2,4-
dimethyl benzaldehyde
FL/FR
para-
methyl anisole
FL/FR
nutty
2-
acetyl furan
FL/FR
2-
benzofuran carboxaldehyde
FL/FR
3,5(6)-
cocoa pyrazine
FL
3,5-
cocoa pyrazine
FL/FR
2-
methoxy-3-methyl pyrazine
FL/FR
phenolic
methyl benzoate
FL/FR
phenyl pyruvic acid
FL/FR
powdery
acetophenone
FL/FR
beta-
naphthyl ethyl ether
FL/FR
powdery ketone
FL
spicy
para-
anisyl methyl ketone
FL/FR
benzylidene acetone
FL
sweet
cyclohexyl acetic acid
FL/FR
tarragon
sassafras acetate
FL/FR
vanilla
omega-
pentadecalactone
FL/FR
vanillyl acetate
FL/FR
waxy
rhodinyl phenyl acetate
FL/FR
woody
guaiacwood oil
FL/FR
(E)-beta-
ionone
FL/FR
alpha-
irone
FL/FR
methyl ionyl acetate
FL/FR
 
Potential Uses:
FRalmond
FRamber
FRambrette oil replacer
FRazalea
FRbaby powder
FRbalsam
FRhawthorn
FRhay new mown hay
 hugonia
FRmimosa
FRperu balsam
FRpowder
FRrose white rose
FRspice
 
Occurrence (nature, food, other):note
 found in nature
 
Synonyms:
o-acetanisole
 acetophenone, 2'-methoxy-
2-acetyl anisole
o-acetyl anisole
ortho-acetyl anisole
1-acetyl-2-methoxybenzene
2-acetylanisole
o-acetylanisole
 ethanone, 1-(2-methoxyphenyl)-
2-methoxy-acetophenon
1-(2-methoxy-phenyl)-ethanone
2-methoxyacetophenone
2'-methoxyacetophenone
o-methoxyacetophenone
ortho-methoxyacetophenone
2-methoxyphenyl methyl ketone
1-(2-methoxyphenyl) ethan-1-one
1-(2-methoxyphenyl)ethan-1-one
1-(2-methoxyphenyl)ethanone
 methyl 2-methoxyphenyl ketone
 methyl o-methoxyphenyl ketone
 methyl ortho-methoxyphenyl ketone
 
 
Notes:
Used as a food additive [EAFUS]
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