EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

6-methyl quinoline
6-methylquinoline

Supplier Sponsors

Name:6-methylquinoline
CAS Number: 91-62-3Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:202-084-6
FDA UNII:K14453I13N
Nikkaji Web:J800A
Beilstein Number:0110336
MDL:MFCD00006804
CoE Number:2339
XlogP3:2.60 (est)
Molecular Weight:143.18873000
Formula:C10 H9 N
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:flavor and fragrance agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
JECFA Food Flavoring:1302 6-methylquinoline
FLAVIS Number:14.042 (Old)
DG SANTE Food Flavourings:14.042 6-methylquinoline
FEMA Number:2744 6-methylquinoline
FDA:No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF):91-62-3 ; 6-METHYLQUINOLINE
 
Physical Properties:
Appearance:pale yellow to amber brown clear liquid (est)
Assay: 98.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:1.06000 to 1.06600 @ 25.00 °C.
Pounds per Gallon - (est).: 8.820 to 8.870
Specific Gravity:1.06300 to 1.07100 @ 20.00 °C.
Pounds per Gallon - est.: 8.856 to 8.922
Refractive Index:1.61100 to 1.61700 @ 20.00 °C.
Melting Point: -22.00 °C. @ 760.00 mm Hg
Boiling Point: 259.00 to 261.00 °C. @ 760.00 mm Hg
Vapor Pressure:0.022000 mmHg @ 25.00 °C. (est)
Flash Point:> 230.00 °F. TCC ( > 110.00 °C. )
logP (o/w): 2.570
Soluble in:
 alcohol
 dipropylene glycol
 water, 631.1 mg/L @ 25 °C (est)
Insoluble in:
 water
 
Organoleptic Properties:
Odor Type: animal
Odor Strength:high ,
recommend smelling in a 1.00 % solution or less
Substantivity:400 hour(s) at 10.00 % in dipropylene glycol
leathery tonka castoreum tobacco civet fecal
Odor Description:at 1.00 % in dipropylene glycol. leather tonka castoreum tobacco civet fecal
Luebke, William tgsc, (1990)
Odor sample from: International Flavors & Fragrances Inc.
Flavor Type: animal
animal tonka naphthyl tobacco anisic phenolic
Taste Description: sweet animal tonka naphthyl tobacco anisic phenolic
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: perfuming agents
 
Suppliers:
Augustus Oils
Para Methyl Quinolene
Services
EMD Millipore
For experimental / research use only.
6-Methylquinoline
Indukern F&F
6-METHYL QUINOLINE
Odor: ANIMAL, LEATHER, TONKA, CIVET
Jalor-Chem
For experimental / research use only.
6-methylquinoline
Moellhausen
6-METHYL QUINOLEINE
Odor: Animalic; Earthy
OQEMA
Paramethylquinolene
Parchem
6-methyl quinoline
Penta International
6-METHYLQUINOLINE
Perfumer Supply House
6-Methyl Quinoline
Odor: A leathery, animalic, fecal note reminiscent of castoreum or civet. In dilution, smells of tobacco
Sigma-Aldrich
6-Methylquinoline, ≥98%, FG
Certified Food Grade Products
Synerzine
6-Methyl Quinoline
TCI AMERICA
For experimental / research use only.
6-Methylquinoline >98.0%(GC)(T)
 
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
Xn - Harmful.
R 22 - Harmful if swallowed.
R 36/37/38 - Irritating to eyes, respiratory system, and skin.
R 40 - Limited evidence of a carcinogenic effect.
S 02 - Keep out of the reach of children.
S 20/21 - When using do not eat, drink or smoke.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Human Experience:
2 % solution: no irritation or sensitization.
Oral/Parenteral Toxicity:
oral-rat LD50 800 mg/kg
(Soviet Toxicologic Center, 1984)

oral-rat LD50 1260 mg/kg
(Moreno, 1976y)

oral-rat LD50 800 mg/kg
BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 28(12), Pg. 56, 1984.

Dermal Toxicity:
skin-rabbit LD50 5000 mg/kg
Food and Cosmetics Toxicology. Vol. 17, Pg. 871, 1979.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: flavor and fragrance agents
Recommendation for 6-methyl quinoline usage levels up to:
  1.0000 % in the fragrance concentrate.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 0.32 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 0.01 (μg/capita/day)
Structure Class: III
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
 average usual ppmaverage maximum ppm
baked goods: -1.80000
beverages(nonalcoholic): -0.22000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: -1.40000
fruit ices: -1.40000
gelatins / puddings: --
granulated sugar: --
gravies: --
hard candy: -1.80000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --
 
Food categories according to Commission Regulation EC No. 1565/2000 (EC, 2000) in FGE.06 (EFSA, 2002a). According to the Industry the "normal" use is defined as the average of reported usages and "maximum use" is defined as the 95th percentile of reported usages (EFSA, 2002i).
Note: mg/kg = 0.001/1000 = 0.000001 = 1/1000000 = ppm.
 average usage mg/kgmaximum usage mg/kg
Dairy products, excluding products of category 02.0 (01.0): 0.0240019.00000
Fats and oils, and fat emulsions (type water-in-oil) (02.0): 2.90000-
Edible ices, including sherbet and sorbet (03.0): -9.70000
Processed fruit (04.1): --
Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2): --
Confectionery (05.0): 2.9000029.00000
Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0): 5.00000-
Bakery wares (07.0): 1.5000013.00000
Meat and meat products, including poultry and game (08.0): --
Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0): --
Eggs and egg products (10.0): --
Sweeteners, including honey (11.0): --
Salts, spices, soups, sauces, salads, protein products, etc. (12.0): 1.20000-
Foodstuffs intended for particular nutritional uses (13.0): --
Non-alcoholic ("soft") beverages, excl. dairy products (14.1): 0.00058-
Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2): --
Ready-to-eat savouries (15.0): --
Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0): --
 
Safety References:
European Food Safety Athority(efsa):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Flavouring Group Evaluation 24 (FGE.24): Pyridine, pyrrole, indole and quinoline derivatives from chemical group 28 (Commission Regulation (EC) No 1565/2000 of 18 July 2000)
View page or View pdf

Pyridine, pyrrole, indole and quinoline derivatives from chemical group 28 Flavouring Group Evaluation 24, Revision 1 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf

Flavouring Group Evaluation 77 (FGE77) [1] - Consideration of Pyridine, Pyrrole and Quinoline Derivatives evaluated by JECFA (63rd meeting) structurally related to Pyridine, Pyrrole, Indole and Quinoline Derivatives evaluated by EFSA in FGE.24Rev1 (2008)
View page or View pdf

Statement on List of Representative Substances for Testing. The current Statement lays down a list of substances in sub-groups with representative substances for which additional data are required prior to their evaluation through the Procedure (Regulation (EC) No 1565/2000).
View page or View pdf

Scientific opinion on Flavouring Group Evaluation 24, Revision 2 (FGE.24Rev2): Pyridine, pyrrole, indole and quinoline derivatives from chemical group 28
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 77, Revision 2 (FGE.77Rev2): Consideration of Pyridine, Pyrrole and Quinoline Derivatives evaluated by JECFA (63rd meeting) structurally related to Pyridine, Pyrrole, Indole and Quinoline Derivatives evaluated by EFSA in FGE.24Rev2 (2013)
View page or View pdf

Scientific opinion on flavouring group evaluation 77, revision 3 (FGE.77Rev3): consideration of pyridine, pyrrole and quinoline derivatives evaluated by JECFA (63rd meeting) structurally related to pyridine, pyrrole, indole and quinoline derivatives evaluated by EFSA in FGE.24Rev2
View page or View pdf

EPI System: View
Chemical Carcinogenesis Research Information System:Search
Cancer Citations:Search
Toxicology Citations:Search
Carcinogenic Potency Database:Search
EPA GENetic TOXicology:Search
Env. Mutagen Info. Center:Search
EPA Substance Registry Services (TSCA):91-62-3
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :7059
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
6-methylquinoline
Chemidplus:0000091623
EPA/NOAA CAMEO:hazardous materials
RTECS:VC0550000 for cas# 91-62-3
 
References:
 6-methylquinoline
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:91-62-3
Pubchem (cid):7059
Pubchem (sid):134971581
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
CHEMBL:View
HMDB (The Human Metabolome Database):HMDB33115
FooDB:FDB011115
Export Tariff Code:2933.49.7000
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
 
Potential Blenders and core components note
For Odor
No odor group found for these
7-
methyl coumarin replacer
FR
amber
amber
ambrette seed absolute
FL/FR
animal
animal fragrance
FR
iso
butyl quinoline
FR
iso
butyl quinoline
FR
2-iso
butyl quinoline
FR
6-tert-
butyl-meta-cresol
FL/FR
para-
methyl tetrahydroquinoline
FL/FR
procavia capensis excrete absolute
FR
skatole
FL/FR
1,2,3,4-
tetrahydroquinoline
FR
balsamic
amyl phenyl acetate
FL/FR
pine needle absolute
FL/FR
burnt
amber oil
FR
caramellic
immortelle absolute
FL/FR
cereal
bran absolute
FR
chocolate
iso
amyl phenyl acetate
FL/FR
coconut
coconut decanone methyl
FR
coconut naphthalenone
FL/FR
gamma-
heptalactone
FL/FR
coumarinic
coumane
FL/FR
phthalide
FL/FR
tonka bean oleoresin
FR
tonka bean resinoid
FR
tonka furanone
FL/FR
tonka ketone
FR
tonkavert
FR
creamy
para-
vanillyl alcohol
FL/FR
floral
alpha-
amyl cinnamyl acetate
FL/FR
boronia butenal
FR
citronellol
FL/FR
delta-
damascone
FL/FR
dimethyl octanol
FL/FR
floral methanol
FR
orris pyridine 25% IPM
FR
tobacco flower absolute
FR
fruity
alpha-
amyl cinnamyl isovalerate
FL/FR
cyclohexanone diethyl acetal
FL/FR
(E)-beta-
damascone
FL/FR
beta-
damascone
FL/FR
(Z)-beta-
damascone
FL/FR
ethyl 3-hydroxyhexanoate
FL/FR
leather propionate
FR
osmanthus flower absolute
FL/FR
fungal
methyl 2-furoate
FL/FR
green
narcissus flower absolute
FR
oakmoss oil
FR
phenoxyacetaldehyde 50% in benzyl alcohol
FR
syringaldehyde
FL/FR
hay
beeswax absolute
FL/FR
hay absolute
FR
tobacco leaf absolute
FL/FR
woodruff absolute
FR
herbal
matricaria chamomilla flower oil
FL/FR
methyl nicotinate
FL/FR
saffron indenone
FL/FR
safranal
FL/FR
theaspirane
FL/FR
thyme undecane
FR
yerba mate absolute
FL/FR
honey
phenyl acetic acid
FL/FR
leathery
4-tert-
butyl phenol
CS
castoreum absolute
FL/FR
leather cyclohexanol
FR
marine
marine pyridine
FR
musk
musk amberol
FR
musty
ketoiso
phorone
FL/FR
nutty
2,3-
dimethyl pyrazine
FL/FR
phenolic
2'-
hydroxyacetophenone
FL/FR
popcorn
2-
acetyl pyridine
FL/FR
powdery
para-
anisyl acetate
FL/FR
smoky
alpha-
ethoxy-ortho-cresol
FL/FR
spicy
cuminyl alcohol
FL/FR
N,N-
diethyl octanamide
FR
4-
methyl guaiacol
FL/FR
myrtenal
FL/FR
tobacco
para-
cresyl isovalerate
FL/FR
3-
ethyl pyridine
FL/FR
methyl benzoxole
FL/FR
tobacco concrete
FR
(E,E/E,Z)-
tobacco cyclohexenone
FL/FR
veltonal (Bedoukian)
FR
tonka
6-
amyl-alpha-pyrone
FL/FR
coumarin
FR
deertongue absolute
FR
deertongue oleoresin
FR
flouve absolute
FR
gamma-
hexalactone
FL/FR
7-
methyl coumarin
CS
mint lactone
FL/FR
octahydrocoumarin
FL/FR
saffron resinoid
FL/FR
tonka bean absolute
FR
tonka undecanone
FR
whiskey lactone
FL/FR
tropical
genet absolute
FL/FR
vanilla
propenyl guaethol
FL/FR
woody
amber decatriene
FR
alpha-
cedrene epoxide
FR
iso
longifolene ketone
FR
methyl cedryl ketone
FL/FR
tobacarol (IFF)
FR
tobacco nonene
FR
woody dioxolane
FR
woody ether
FR
For Flavor
No flavor group found for these
amyl phenyl acetate
FL/FR
6-tert-
butyl-meta-cresol
FL/FR
capsicum oleoresin
FL
coconut naphthalenone
FL/FR
coumane
FL/FR
cyclohexanone diethyl acetal
FL/FR
2,6-
dimethoxy-4-vinyl phenol
FL
alpha-
ethoxy-ortho-cresol
FL/FR
fig leaf absolute
FL
2-
furfurylidene butyraldehyde
FL
7-
methoxycoumarin
FL
methyl nicotinate
FL/FR
para-
methyl tetrahydroquinoline
FL/FR
pine needle absolute
FL/FR
2-
propyl pyridine
FL
skatole
FL/FR
tonka furanone
FL/FR
(R)-
tonka furanone
FL
beta-
damascone
FL/FR
brown
brown
beeswax absolute
FL/FR
caramellic
3-
ethyl pyridine
FL/FR
methyl 2-furoate
FL/FR
citrus
ketoiso
phorone
FL/FR
cocoa
syringaldehyde
FL/FR
coconut
octahydrocoumarin
FL/FR
cooling
theaspirane
FL/FR
corn
2-
acetyl pyridine
FL/FR
coumarinic
phthalide
FL/FR
creamy
6-
amyl-alpha-pyrone
FL/FR
dihydrocoumarin
FL
gamma-
hexalactone
FL/FR
mint lactone
FL/FR
para-
vanillyl alcohol
FL/FR
earthy
alpha-
amyl cinnamyl acetate
FL/FR
fatty
dimethyl octanol
FL/FR
floral
iso
amyl phenyl acetate
FL/FR
citronellol
FL/FR
phenyl acetic acid
FL/FR
fruity
alpha-
amyl cinnamyl isovalerate
FL/FR
para-
anisyl acetate
FL/FR
(E)-beta-
damascone
FL/FR
(Z)-beta-
damascone
FL/FR
ethyl 3-hydroxyhexanoate
FL/FR
osmanthus flower absolute
FL/FR
grassy
tobacco leaf absolute
FL/FR
green
immortelle absolute
FL/FR
hay
genet absolute
FL/FR
herbal
matricaria chamomilla flower oil
FL/FR
saffron indenone
FL/FR
yerba mate absolute
FL/FR
lactonic
gamma-
heptalactone
FL/FR
leathery
castoreum absolute
FL/FR
minty
myrtenal
FL/FR
naphthyl
2'-
hydroxyacetophenone
FL/FR
nutty
2,3-
dimethyl pyrazine
FL/FR
methyl benzoxole
FL/FR
(E,E/E,Z)-
tobacco cyclohexenone
FL/FR
phenolic
para-
cresyl isovalerate
FL/FR
spicy
cuminyl alcohol
FL/FR
levisticum officinale oleoresin
FL
paprika oleoresin
FL
sweet
saffron resinoid
FL/FR
vanilla
4-
methyl guaiacol
FL/FR
propenyl guaethol
FL/FR
woody
ambrette seed absolute
FL/FR
delta-
damascone
FL/FR
methyl cedryl ketone
FL/FR
safranal
FL/FR
whiskey lactone
FL/FR
 
Potential Uses:
FRamber
FRanimal
FRbalsam
FRcastoreum
FRcivet
FRearth
FRgreen
FRhay new mown hay
FRleather
FRlilac
FRlinden flower
FRmoss
FRocean sea
FRtobacco
FRtonka bean
 
Occurrence (nature, food, other):note
 tea leaf
Search Trop Picture
 whiskey
Search Picture
 
Synonyms:
 khinaldin
6-methylchinolin
6-methylquinoline
 paramethylquinolene
 quinoline, 6-methyl-
 

Articles:

PubMed:Heterocyclic Aromatic Hydrocarbons Show Estrogenic Activity upon Metabolization in a Recombinant Transactivation Assay.
PubMed:Genotoxicity of heterocyclic PAHs in the micronucleus assay with the fish liver cell line RTL-W1.
PubMed:Molecules of the quinoline family block tau self-aggregation: implications toward a therapeutic approach for Alzheimer's disease.
PubMed:Synthesis and in-vitro antimicrobial activity of secondary and tertiary amines containing 2-chloro-6-methylquinoline moiety.
PubMed:4-Azido-2-chloro-6-methyl-quinoline.
PubMed:Novel chalcones derived from 2-chloro-3-formyl-6-methylquinoline.
PubMed:Heterocyclic compounds: toxic effects using algae, daphnids, and the Salmonella/microsome test taking methodical quantitative aspects into account.
PubMed:Tetra-μ-benzoato-bis-[(6-methyl-quino-line)-copper(II)].
PubMed:Inclusion of quinolines by binaphthol: structures and selectivity.
PubMed:Chloride-sensitive fluorescent indicators.
PubMed:The formation of 1-hydroxymethylnaphthalene and 6-hydroxymethylquinoline by both oxidative and reductive routes in Cunninghamella elegans.
PubMed:Hydroxylation and biodegradation of 6-methylquinoline by pseudomonads in aqueous and nonaqueous immobilized-cell bioreactors.
PubMed:The hepatic metabolism of two methylquinolines.
PubMed:Uptake and biotransformation of 6,7-dimethylquinoline and 6,8-dimethylquinoline by rainbow trout (Salmo gairdneri).
PubMed:Studies on antibiotic biosynthesis by protoplasts and resting cells of Streptomyces echinatus. Part II. Effect of chromophore precursors.
PubMed:Directed biosynthesis of novel derivatives of echinomycin. II. Purification and structure elucidation.
PubMed:Directed biosynthesis of novel derivatives of echinomycin by Streptomyces echinatus. I. Effect of exogenous analogues of quinoxaline-2-carboxylic acid on the fermentation.
PubMed:Study of artificial flavouring substances for mutagenicity in the Salmonella/microsome, Basc and micronucleus tests.
PubMed:Carcinogenicities of quinoline derivatives in F344 rats.
PubMed:Toxic interaction of mixtures of two coal conversion effluent components (resorcinol and 6-methylquinoline) to Daphnia magna.
PubMed:Determination of quinomethionate (6-methylquinoline-2,3-diyldithiocarbonate) residues in crops by in situ fluorometry.
PubMed:[Production and purification of quinoline bases. 6. Modified arrangement of 6-methylquinoline-N-oxide in the 4 position].
PubMed:Some derivatives of 6-methylquinoline.
 
Notes:
Flavouring ingredient
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