methyl nicotinate
3-pyridinecarboxylic acid, methyl ester
erythema provoked is basis of a methylnicotinate test of anti-inflammatories. Flavouring ingredient. Present in guava fruit, papaya, strawberry, soursop (Annona muricata), beer, grape brandy, coffee, roasted filbert, roasted peanut and Bourbon vanilla
  • American International Chemical, LLC.
    • American International Chemical, Inc.
      Consistent sources
      North American supplier for globally sourced ingredients.
      AIC is a Framingham, MA based ISO Certified sales and marketing company serving the food, pharmaceutical, nutritional, personal care, biotech, and industrial markets of North America since 1972. Our success is a result of a company culture built on customer needs, along with partnerships with global manufacturers committed to the rigors and demands of the North American market. Our team of 30 Sales Representatives, along with our 19 strategically located warehouses are ready to supply product when and where you need it.
      Email: Info
      Voice: (800) 238-0001
      102814 Methyl Nicotinate
  • M&U International
    • M&U International LLC
      Steady supply & demand
      Meeting customers increasing demands at home as well as abroad.
      M&U dedicates itself to the development and production of new products as well as continuously promoting those new products. We’ve maintained a steady supply&demand relationship with a large number of manufacturers at home and abroad. We’ve developed an extensive network and because of our relationships with these manufacturers, we’re able to provide a stable supply of great quality materials. We’re located in China’s largest communications hub, Shanghai and in the U.S. near one of the largest sea ports on the East Coast. The strategic locations of our facilities ensure convenient, prompt and secure delivery of our products to our customers. We warmly welcome your inquiries, come witness our solemn commitment for yourself.
      Email: Sales
      US Email: Sales
      Voice: +86-21-32515501 60762991 60762992
      Fax: +86-21-32515502 64204960
      US Voice: 908-359-9000
      US Fax: 908-359-9002
      A0254 METHYL NICOTINATE, Kosher
  • Penta International
    • Penta International Corporation
      Chemistry innovation
      At Penta, our products and services help businesses do business better.
      For over 30 years, Penta Manufacturing Company has played a growing role in worldwide chemistry innovations and applications. As an industry leader, Penta continues to pioneer chemistry-based solutions for practically every area of commerce. Our products and expertise have helped fuel technical advances in dozens of commercial applications including flavoring, coloring, fragrances and chemical processes.
      US Email: Technical Services
      US Email: Sales
      US Voice: (973) 740-2300
      US Fax: (973) 740-1839
      13-57600 METHYL NICOTINATE, Kosher
  • Sigma-Aldrich
    • Sigma-Aldrich
      Complete Supply Chain
      The perfect blend of products and services that bring your creativity to life.
      Sigma-Aldrich is a leading Life Science and High Technology company dedicated to providing high-quality, safe and certified flavor ingredients with transparent and easily accessible documentation to customers around the globe. Sigma-Aldrich also provides a suite of analytical tools that allow food analysts to simplify sample preparation, cleanup and analysis steps, while increasing sensitivity to trace ingredients and harmful substances to meet regulations and quality standards.
      Email: Information
      US Email: Sales
      US Voice: 800-244-1173
      US Fax: 800-368-4661
      Certified Food Grade Products
      W370908 Methyl nicotinate, ≥99%, FG
  • Synerzine
    • Synerzine, Inc.
      Innovation. Customization. Aroma Ingredients.
      Synerzine is a leading supplier of flavor and fragrance ingredients.
      Synerzine expresses what we have grown to embody as an organization - the synergy and connection between raw ingredients, science, technology, and the final product. Our experienced team is passionate about bringing our customers high-quality innovative ingredients that they can trust.
      Building upon our 44 year history, the Synerzine team provides customers around the globe with convenient access to over 1200 high-quality aroma ingredients. We actively engage with customers to add a wide array of new products and services on a regular basis. Our aim is to delight every customer with our exceptional services, large product selection, customization and the highest quality and safety standards. We provide our customers with true value designed to help them bring their products to market faster.
      US Email: Customer Service
      US Email: Sales
      US Voice: (404) 524-6744
      US Fax: (404) 577-1651
      Products List: View
      W1337 Methyl Nicotinate
      Moving Your Chemistry Forward
      We continuously strive to advance our technology.
      Tokyo Chemical Industry Co., Ltd. (TCI) is a leading worldwide manufacturer of specialty organic chemicals founded in 1946. TCI provides organic laboratory chemicals as well as pharmaceutical, cosmetic and functional materials. More than 60 years of synthesis experience and multi-purpose plants enable TCI to offer more than 27,000 products as well as custom synthesis. TCI established overseas facilities in North America, Europe, China and India to serve customers worldwide.
      Email: Sales
      US Email: Sales
      Email: Global Business
      Voice: +81-3-5640-8878
      Fax: +81-3-5640-8902
      US Voice: 800-423-8616
      US Fax: 888-520-1075
      Tokyo Tel:03-5640-8851
      Tokyo Fax:03-5640-8865
      N0086 Methyl Nicotinate >98.0%(GC)
Synonyms   Articles   Notes   Search
    Flavor Demo Formulas
methyl pyridine-3-carboxylate (Click)
CAS Number: 93-60-7Picture of molecule
ECHA EINECS - REACH Pre-Reg: 202-261-8
Nikkaji Web: J39.098D
Beilstein Number: 0113951
MDL: MFCD00006388
CoE Number: 14071
XlogP3: 0.80 (est)
Molecular Weight: 137.13819000
Formula: C7 H7 N O2
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: flavor and fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist: Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
JECFA Food Flavoring: 1320  methyl nicotinate
Flavis Number: 14.071 (Old)
DG SANTE Food Flavourings: 14.071  methyl nicotinate
FEMA Number: 3709  methyl nicotinate
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Physical Properties:
Appearance: colorless to pale yellow solid (est)
Assay: 98.00 to 100.00 % 
Food Chemicals Codex Listed: No
Melting Point: 38.00 to  43.00 °C. @ 760.00 mm Hg
Boiling Point: 209.00 °C. @ 760.00 mm Hg
Vapor Pressure: 0.208000 mm/Hg @ 25.00 °C. (est)
Flash Point: 204.00 °F. TCC ( 95.56 °C. )
logP (o/w): 0.830
Soluble in:
 water, 47600 mg/L @ 20 °C (exp)
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Organoleptic Properties:
Odor Type: herbal
Odor Strength: medium ,
recommend smelling in a 10.00 % solution or less
 warm  herbal  tobacco  
Odor Description:
at 10.00 % in dipropylene glycol. 
warm herbal tobacco
Odor and/or flavor descriptions from others (if found).
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: soothing agents
Synonyms   Articles   Notes   Search   Top
Methyl Nicotinate
American International Chemical, LLC.
Methyl Nicotinate
BOC Sciences
For experimental / research use only.
Methyl Nicotinate 98%
EMD Millipore
For experimental / research use only.
Methyl Nicotinate
M&U International
Penta International
Santa Cruz Biotechnology
For experimental / research use only.
Methyl Nicotinate
Methyl nicotinate, ≥99%, FG
Odor: herbaceous; tobacco
Certified Food Grade Products
Methyl Nicotinate
For experimental / research use only.
Methyl Nicotinate >98.0%(GC)
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Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
Xi - Irritant
R 36/37/38 - Irritating to eyes, respiratory system, and skin.
S 02 - Keep out of the reach of children.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 37/39 - Wear suitable gloves and eye/face protection.
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-mouse LD50  2800 mg/kg
(Pellmont, 1977)

parenteral-mouse LDLo  2000 mg/kg
"Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. Vol. 7, Pg. 691, 1955.

Dermal Toxicity:
subcutaneous-mouse LD > 1000 mg/kg
"Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948Vol. -, Pg. 428, 1948.

Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: flavor and fragrance agents
Recommendation for methyl nicotinate usage levels up to:
  0.5000 % in the fragrance concentrate.
Maximised Survey-derived Daily Intakes (MSDI-EU): 0.49 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 0.20 (μg/capita/day)
Structure Class: II
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 13
Click here to view publication 13
 average usual ppmaverage maximum ppm
baked goods: -40.00000
beverages(nonalcoholic): -2.00000
beverages(alcoholic): -10.00000
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: -10.00000
fruit ices: --
gelatins / puddings: -10.00000
granulated sugar: --
gravies: --
hard candy: -20.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: -20.00000
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --
Synonyms   Articles   Notes   Search   Top
Safety References:
European Food Safety Athority(efsa): Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...
European Food Safety Authority (EFSA) reference(s):
Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Flavouring Group Evaluation 24 (FGE.24): Pyridine, pyrrole, indole and quinoline derivatives from chemical group 28 (Commission Regulation (EC) No 1565/2000 of 18 July 2000)
View page or View pdf
Pyridine, pyrrole, indole and quinoline derivatives from chemical group 28 Flavouring Group Evaluation 24, Revision 1 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf
Flavouring Group Evaluation 77 (FGE77) [1] - Consideration of Pyridine, Pyrrole and Quinoline Derivatives evaluated by JECFA (63rd meeting) structurally related to Pyridine, Pyrrole, Indole and Quinoline Derivatives evaluated by EFSA in FGE.24Rev1 (2008)
View page or View pdf
Scientific Opinion on Flavouring Group Evaluation 77, Revision 2 (FGE.77Rev2): Consideration of Pyridine, Pyrrole and Quinoline Derivatives evaluated by JECFA (63rd meeting) structurally related to Pyridine, Pyrrole, Indole and Quinoline Derivatives evaluated by EFSA in FGE.24Rev2 (2013)
View page or View pdf
EPI System: View search
Daily Med: search
Cancer Citations: Search
Toxicology Citations: Search
NLM Developmental and Reproductive Toxicity: Search
EPA Substance Registry Services (TSCA): 93-60-7
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 7151
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 3
 methyl pyridine-3-carboxylate
Chemidplus: 0000093607
RTECS: QT1925000 for cas# 93-60-7
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 methyl pyridine-3-carboxylate
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 93-60-7
Pubchem (cid): 7151
Pubchem (sid): 134973005
Pherobase: View
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS): View
KEGG (GenomeNet): D04991
HMDB (The Human Metabolome Database): HMDB29806
FooDB: FDB001015
Export Tariff Code: 2933.39.9100
Typical G.C.
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
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Potential Blenders and core components note
For Odor
No odor group found for these
 fleabane oil (conyza canadensis) 
 agrumen nitrileFR
 ambrette seed absoluteFL/FR
6-methyl quinolineFL/FR
 amyl phenyl acetateFL/FR
 bran absoluteFR
 boronia butenalFR
 coriander seed oilFL/FR
 tobacco flower absoluteFR
alpha-amyl cinnamyl isovalerateFL/FR
 cyclohexanone diethyl acetalFL/FR
 ethyl 3-hydroxyhexanoateFL/FR
 perillyl acetateFL/FR
 methyl 2-furoateFL/FR
sec-butyl-3-methyl but-2-ene thioateFL/FR
 carrot leaf oil (daucus carota ssp.maximus)FR
 privet dioxaneFR
 beeswax absoluteFL/FR
 hay absoluteFR
 tobacco leaf absoluteFL/FR
 woodruff absoluteFR
 carvacryl methyl etherFL/FR
 coriander seed absoluteFL/FR
 coriander seed concreteFR
 herbal acetalFR
 matricaria chamomilla flower oilFL/FR
1-para-menthen-9-yl acetateFL/FR
curled parsley seed oilFL/FR
 saffron indenoneFL/FR
 thymyl methyl etherFL/FR
 yerba mate absoluteFL/FR
 phenyl acetic acidFL/FR
2-acetyl pyridineFL/FR
isobutyl (E,E)-2,4-decadienamideFL/FR
 carrot weed oilFL/FR
 carvacryl ethyl etherFL/FR
 cinnamaldehyde dimethyl acetalFL/FR
 cuminyl alcoholFL/FR
black currant bud absoluteFL/FR
N,N-diethyl octanamideFR
sweet marjoram oil (origanum majorana var. tenuifolium weston) cyprus 
 origanum majorana oilFL/FR
 origanum majorana oil cubaFL/FR
 origanum majorana oil moroccoFL/FR
para-cresyl isovalerateFL/FR
3-ethyl pyridineFL/FR
 methyl benzoxoleFL/FR
 tobacco concreteFR
(E,E/E,Z)-tobacco cyclohexenoneFL/FR
 veltonal (Bedoukian)FR
 deertongue absoluteFR
 mint lactoneFL/FR
 saffron resinoidFL/FR
 tonka undecanoneFR
 genet absoluteFL/FR
 propenyl guaetholFL/FR
 amber decatrieneFR
alpha-cedrene epoxideFR
isolongifolene ketoneFR
 patchouli absoluteFR
 tobacarol (IFF)FR
 tobacco noneneFR
 woody dioxolaneFR
 woody etherFR
For Flavor
No flavor group found for these
 amyl phenyl acetateFL/FR
isobutyl (E,E)-2,4-decadienamideFL/FR
sec-butyl-3-methyl but-2-ene thioateFL/FR
 carvacryl ethyl etherFL/FR
 carvacryl methyl etherFL/FR
 cyclohexanone diethyl acetalFL/FR
2,4-dimethyl anisoleFL
 fig leaf absoluteFL
 fleabane oil (conyza canadensis) 
 fleabane oil (erigeron canadensis)FL
sweet marjoram oil (origanum majorana var. tenuifolium weston) cyprus 
2-propyl pyridineFL
 hexyl 3-mercaptobutanoateFL
6-methyl quinolineFL/FR
 perillyl acetateFL/FR
 beeswax absoluteFL/FR
3-ethyl pyridineFL/FR
 methyl 2-furoateFL/FR
2-acetyl pyridineFL/FR
 mint lactoneFL/FR
 phenyl acetic acidFL/FR
alpha-amyl cinnamyl isovalerateFL/FR
 ethyl 3-hydroxyhexanoateFL/FR
1-para-menthen-9-yl acetateFL/FR
 tobacco leaf absoluteFL/FR
 carrot weed oilFL/FR
 genet absoluteFL/FR
 coriander seed absoluteFL/FR
 coriander seed oilFL/FR
 matricaria chamomilla flower oilFL/FR
 origanum majorana oilFL/FR
curled parsley seed oilFL/FR
 saffron indenoneFL/FR
 yerba mate absoluteFL/FR
 thymyl methyl etherFL/FR
 methyl benzoxoleFL/FR
(E,E/E,Z)-tobacco cyclohexenoneFL/FR
para-cresyl isovalerateFL/FR
 cinnamaldehyde dimethyl acetalFL/FR
 cuminyl alcoholFL/FR
black currant bud absoluteFL/FR
 origanum majorana oil cubaFL/FR
 origanum majorana oil moroccoFL/FR
 paprika oleoresinFL
 saffron resinoidFL/FR
 propenyl guaetholFL/FR
 ambrette seed absoluteFL/FR
Synonyms   Articles   Notes   Search   Top
Potential Uses:
 plum mirabelleFR
 soothing agents 
Synonyms   Articles   Notes   Search   Top
Occurrence (nature, food, other): note
Search  PMC Picture
 brandy grape brandy
Search  PMC Picture
 champaca concrete @ 0.15%
Data  GC  Search Trop  Picture
Search  PMC Picture
 filbert roasted filbert
Search Trop  Picture
 guava fruit
Search Trop  Picture
 papaya fruit
Search Trop  Picture
 peanut roasted peanut
Search Trop  Picture
Search Trop  Picture
 strawberry wild strawberry fruit
Search Trop  Picture
Search  Picture
Synonyms   Articles   Notes   Search   Top
3-(methoxycarbonyl) pyridine
 methyl 3-pyridine carboxylate
 methyl 3-pyridinecarboxylate
 methyl pyridine-3-carboxylate
 nicotinic acid methyl ester
 nicotinic acid, methyl ester
3-picolinic acid methyl ester
3-pyridine carboxylic acid methyl ester
3-pyridinecarboxylic acid methyl ester
3-pyridinecarboxylic acid, methyl ester
Synonyms   Articles   Notes   Search   Top
PubMed: Serum biomarkers of habitual coffee consumption may provide insight into the mechanism underlying the association between coffee consumption and colorectal cancer.
PubMed: In vivo determination of the diclofenac skin reservoir: comparison between passive, occlusive, and iontophoretic application.
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PubMed: Conversion of nicotinic acid to trigonelline is catalyzed by N-methyltransferase belonged to motif B' methyltransferase family in Coffea arabica.
PubMed: Effects of neonatal treatment with the TRPV1 agonist, capsaicin, on adult rat brain and behaviour.
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PubMed: Synthesis and antifungal evaluation of (1,2,3-triazol-4-yl)methyl nicotinate chitosan.
PubMed: Assessment of potential causes of falsely positive Mycobacterium tuberculosis breath test.
PubMed: Comfrey root: from tradition to modern clinical trials.
PubMed: Combination of comfrey root extract plus methyl nicotinate in patients with conditions of acute upper or low back pain: a multicentre randomised controlled trial.
PubMed: Systems responses of rats to mequindox revealed by metabolic and transcriptomic profiling.
PubMed: Detection and visualization of intracutaneous allergic type-specific elements using long-wavelength near-infrared hyperspectral imaging.
PubMed: Niacin subsensitivity is associated with functional impairment in schizophrenia.
PubMed: Diagnosis of tuberculosis by trained African giant pouched rats and confounding impact of pathogens and microflora of the respiratory tract.
PubMed: Honeybees Apis mellifera can detect the scent of Mycobacterium tuberculosis.
PubMed: Persistent erythema with niacin is not attributable to aspirin resistance.
PubMed: Perturbation of solute transport at a liquid-liquid interface by polyethylene glycol (PEG): implications for PEG-induced biomembrane fusion.
PubMed: Niacin sensitivity and the arachidonic acid pathway in schizophrenia.
PubMed: Alterations of niacin skin sensitivity in recurrent unipolar depressive disorder.
PubMed: Preparation and anti-inflammatory activity of triptolide ethosomes in an erythema model.
PubMed: In vitro cutaneous application of ISCOMs on human skin enhances delivery of hydrophobic model compounds through the stratum corneum.
PubMed: Excess substrate is a spectator ligand in a rhodium-catalyzed asymmetric [2 + 2 + 2] cycloaddition of alkenyl isocyanates with tolanes.
PubMed: Simultaneous monitoring of drug and solvent diffusion across a model membrane using ATR-FTIR spectroscopy.
PubMed: Comparison of instruments for investigation of microcirculatory blood flow and red blood cell concentration.
PubMed: Effects of lipid nanocarriers on the performance of topical vehicles in vivo.
PubMed: The scent of Mycobacterium tuberculosis--part II breath.
PubMed: Anti-inflammatory activity of parthenolide-depleted Feverfew (Tanacetum parthenium).
PubMed: A quercetin containing supplement reduces niacin-induced flush in humans.
PubMed: Stability of methylnicotinate in aqueous solution as utilized in the 'niacin patch test'.
PubMed: Niacin-induced "flush" involves release of prostaglandin D2 from mast cells and serotonin from platelets: evidence from human cells in vitro and an animal model.
PubMed: The topical niacin sensitivity test: an inter- and intra-rater reliability study in healthy controls.
PubMed: In vivo spectrophotometric evaluation of skin barrier recovery after topical application of soybean phytosterols.
PubMed: Evaluation of simultaneous permeation and metabolism of methyl nicotinate in human, snake, and shed snake skin.
PubMed: The scent of Mycobacterium tuberculosis.
PubMed: A new coordination mode of 6-methylnicotinic acid in trans-tetraaquabis(6-methylpyridine-3-carboxylato-kappaO)cobalt(II) tetrahydrate.
PubMed: Syntheses of nicotinamide riboside and derivatives: effective agents for increasing nicotinamide adenine dinucleotide concentrations in mammalian cells.
PubMed: Sub-epidermal imaging using polarized light spectroscopy for assessment of skin microcirculation.
PubMed: Endophenotype properties of niacin sensitivity as marker of impaired prostaglandin signalling in schizophrenia.
PubMed: Niacin skin test response in dyslexia.
PubMed: Transfer of the experimental methodology described in the FDA guidance for corticosteroid bioequivalence testing to pharmacodynamic effects caused by nicotinates.
PubMed: Influence of skin colour on the detection of cutaneous erythema and tanning phenomena using reflectance spectrophotometry.
PubMed: Cannabinoids influence lipid-arachidonic acid pathways in schizophrenia.
PubMed: Ethyl 5-[6-(furan-2-yl)-1,2,4-triazolo[3,4-b][1,3,4]thia-diazol-3-yl]-2,6-di-methylnicotinate.
PubMed: A non-invasive method for the in vivo determination of skin antioxidant capacity (IAC-S).
PubMed: Percutaneous penetration of methyl nicotinate from ointments using the laser Doppler technique: bioequivalence and enhancer effects.
PubMed: Time of erythema onset after application of methyl nicotinate ointments as response parameter: influence of penetration kinetics and enhancing agents.
PubMed: Niacin skin flushing in schizophrenic and depressed patients and healthy controls.
PubMed: Determination of the in vivo bioavailability of iontophoretically delivered diclofenac using a methyl nicotinate skin inflammation assay.
PubMed: Cluster analysis of the dermal permeability and stratum corneum/solvent partitioning of ten chemicals in twenty-four chemical mixtures in porcine skin.
PubMed: Establishing a minimal erythema concentration of methyl nicotinate for optimum evaluation of anti-inflammatories.
PubMed: In-vitro and in-vivo evaluation of oligoethylene esters as dermal prodrugs of 18beta-glycyrrhetic acid.
PubMed: Objective biophysical findings in patients with sensitive skin.
PubMed: Anti-inflammatory activity in skin by biomimetic of Evodia rutaecarpa extract from traditional Chinese medicine.
PubMed: Pattern recognition analysis for classification of hypertensive model rats and diurnal variation using 1H-NMR spectroscopy of urine.
PubMed: Predicting skin permeability from complex chemical mixtures.
PubMed: Effect of charge and lipid concentration on in-vivo percutaneous absorption of methyl nicotinate from liposomal vesicles.
PubMed: Ethosomes for skin delivery of ammonium glycyrrhizinate: in vitro percutaneous permeation through human skin and in vivo anti-inflammatory activity on human volunteers.
PubMed: Impaired niacin sensitivity in acute first-episode but not in multi-episode schizophrenia.
PubMed: Clinical microneedle injection of methyl nicotinate: stratum corneum penetration.
PubMed: Sodium-coupled and electrogenic transport of B-complex vitamin nicotinic acid by slc5a8, a member of the Na/glucose co-transporter gene family.
PubMed: Delayed vasodilatory response to methylnicotinate in patients with unipolar depressive disorder.
PubMed: Intramolecular Photocycloaddition of Unsaturated Isoquinuclidines. Synthesis of 2-Azatetracyclo[4.0.0.(4,9)0(7,10)]decanes and 3-Azatetracyclo[,7)0(5,9)]decanes.
PubMed: Association of a long-chain fatty acid-CoA ligase 4 gene polymorphism with depression and with enhanced niacin-induced dermal erythema.
PubMed: High-performance liquid chromatographic determination of arecoline in human saliva.
PubMed: Reduced vasodilatory response to methylnicotinate in schizophrenia as assessed by laser Doppler flowmetry.
PubMed: Preparation of deuterated methyl and dimethyl substituted nicotinoylating agents for derivatization of the N-terminal of protein.
PubMed: Permeation, metabolism and site of action concentration of nicotinic acid derivatives in human skin. Correlation with topical pharmacological effect.
PubMed: On the relationship between methylnicotinate-induced skin flush and fatty acids levels in acute psychosis.
PubMed: Methyl nicotinate-induced vasodilation in generalized social phobia.
PubMed: Determination of antioxidant efficacy of cosmetic formulations by non-invasive measurements.
PubMed: The niacin skin flush abnormality in schizophrenia: a quantitative dose-response study.
PubMed: Topical methyl nicotinate-induced skin vasodilation in diabetic neuropathy.
PubMed: Ketoprofen 1-alkylazacycloalkan-2-one esters as dermal prodrugs: in vivo and in vitro evaluations.
PubMed: Formulation study and anti-inflammatory efficacy of topical semi-solids containing a nitro ester of flurbiprofen.
PubMed: Normal phospholipid-related signal transduction in autism.
PubMed: Comparison of the effects of daily applications between topical corticosteroid and tacrolimus ointments on normal skin: evaluation with noninvasive methods.
PubMed: Effect of chemical interactions in pentachlorophenol mixtures on skin and membrane transport.
PubMed: Influence of processing conditions in the manufacture of O/W creams: II. Effect on drug availability.
PubMed: A volumetric biochemical niacin flush-based index that noninvasively detects fatty acid deficiency in schizophrenia.
PubMed: Impaired phospholipid-related signal transduction in advanced Huntington's disease.
PubMed: Mixture component effects on the in vitro dermal absorption of pentachlorophenol.
PubMed: Selective amination of secoiridoid glycosides to give monomeric pyridine, dimeric pyridine, and naphthyridine alkaloids.
PubMed: The niacin skin flush test in schizophrenia: a replication study.
PubMed: In vitro and in vivo evaluation of polyoxyethylene esters as dermal prodrugs of ketoprofen, naproxen and diclofenac.
PubMed: Selective fowler reductions: asymmetric total syntheses of isofagomine and other 1-azasugars from methyl nicotinate.
PubMed: Release of markedly increased quantities of prostaglandin D2 from the skin in vivo in humans after the application of cinnamic aldehyde.
PubMed: A practical synthesis of a COX-2-specific inhibitor.
PubMed: Unmedicated schizophrenic patients have a reduced skin flush in response to topical niacin.
PubMed: Rheological, mechanical and membrane penetration properties of novel dual drug systems for percutaneous delivery.
PubMed: Microdialysis technique as a method to study the percutaneous penetration of methyl nicotinate through excised human skin, reconstructed epidermis, and human skin in vivo.
PubMed: Microcirculatory response of skin to benzoic acid and methyl nicotinate in patients with diabetes.
PubMed: Novel regioselective hydroxylations of pyridine carboxylic acids at position C2 and pyrazine carboxylic acids at position C3.
PubMed: In-vivo and in-vitro assessment of the free-radical-scavenger activity of Ginkgo flavone glycosides at high concentration.
PubMed: Simultaneous transport and metabolism of nicotinic acid derivatives in hairless mouse skin.
PubMed: Contact sensitizers decrease 33D1 expression on mature Langerhans cells.
PubMed: Correlation between percutaneous penetration of methyl nicotinate and sensitive skin, using laser Doppler imaging.
PubMed: The veno-arteriolar reflex in venous leg ulcer patients studied by laser Doppler imaging.
PubMed: Niacin skin flush in schizophrenia: a preliminary report.
PubMed: Susceptibility to skin stinging, non-immunologic contact urticaria and acute skin irritation; is there a relationship?
PubMed: Cutaneous toxicity of the benzidine dye direct red 28 applied as mechanistically-defined chemical mixtures (MDCM) in perfused porcine skin.
PubMed: Variability in skin microvascular vasodilatory responses assessed by laser-Doppler imaging.
PubMed: Isolation of new 6-methylnicotinic-acid-degrading bacteria, one of which catalyses the regioselective hydroxylation of nicotinic acid at position C2.
PubMed: Esterase-like activity of human serum albumin toward prodrug esters of nicotinic acid.
PubMed: A new method for skin care product evaluation based on the laser Doppler imaging technique.
PubMed: In vitro percutaneous absorption of benzidine in complex mechanistically defined chemical mixtures.
PubMed: The use of mechanistically defined chemical mixtures (MDCM) to assess mixture component effects on the percutaneous absorption and cutaneous disposition of topically exposed chemicals. II. Development of a general dermatopharmacokinetic model for use in risk assessment.
PubMed: The use of mechanistically defined chemical mixtures (MDCM) to assess component effects on the percutaneous absorption and cutaneous disposition of topically exposed chemicals. I. Studies with parathion mixtures in isolated perfused porcine skin.
PubMed: Studies on non-immune immediate contact reactions in an unselected population.
PubMed: Kinetics of release and simulated absorption of methyl nicotinate from different ointment formulations: in vitro-in vivo correlations.
PubMed: Double-blind, placebo-controlled study of the application of capsaicin cream in chronic distal painful polyneuropathy.
PubMed: Enhancing effects of lipophilic vehicles on skin penetration of methyl nicotinate in vivo.
PubMed: Irritant reactions on hairless micropig skin: a model for testing barrier creams?
PubMed: Circadian dosing time dependency in the forearm skin penetration of methyl and hexyl nicotinate.
PubMed: LDV assessment of methyl nicotinate biological response in aqueous solution against that of a w/o microemulsion system.
PubMed: Release of markedly increased quantities of prostaglandin D2 from the skin in vivo in humans following the application of sorbic acid.
PubMed: Phonophoresis of methyl nicotinate: a preliminary study to elucidate the mechanism of action.
PubMed: In vivo differences between Asian, black and white in the stratum corneum barrier function.
PubMed: Assessment of skin erythema by eye, laser Doppler flowmeter, spectroradiometer, two-channel erythema meter and Minolta chroma meter.
PubMed: In vivo evaluation of the stratum corneum barrier function in blacks, Caucasians and Asians with two noninvasive methods.
PubMed: Quantitative evaluation of drug-induced erythema by using a tristimulus colour analyzer: experimental design and data analysis.
PubMed: Feasibility of measuring the bioavailability of topical ibuprofen in commercial formulations using drug content in epidermis and a methyl nicotinate skin inflammation assay.
PubMed: Changes in transepidermal water loss and cutaneous blood flow during the menstrual cycle.
PubMed: A new application chamber for skin penetration studies in vivo with liquid preparations.
PubMed: Effects of local hyperemia and edema on the biological zero in laser Doppler fluxmetry (LD).
PubMed: Identification of skin as a major site of prostaglandin D2 release following oral administration of niacin in humans.
PubMed: Processing and statistical analysis of laser Doppler data applied to the assessment of systemic anti-inflammatory drugs.
PubMed: Cutaneous responses to topical methyl nicotinate in human forearm and vulvar skin.
PubMed: In vivo transcutaneous penetration of nicotinates and sensitive skin.
PubMed: Percutaneous penetration of methyl nicotinate at three anatomic sites: evidence for an appendageal contribution to transport?
PubMed: Objective assessment of topical corticosteroids and non-steroidal anti-inflammatory drugs in methyl-nicotinate-induced skin inflammation.
PubMed: Reduced vasoactive responses in port wine stains.
PubMed: Proton release from flavoprotein D-amino acid oxidase on complexation with the zwitterionic ligand, trigonelline.
PubMed: Pharmacodynamic measurements of methyl nicotinate percutaneous absorption: the effect of aging on microcirculation.
PubMed: Racial differences in pharmacodynamic response to nicotinates in vivo in human skin: black and white.
PubMed: Effects of infra-red and neodymium yttrium aluminium garnet laser irradiation on non-immunologic immediate contact reactions to benzoic acid and methyl nicotinate.
PubMed: PUVA treatment inhibits nonimmunologic immediate contact reactions to benzoic acid and methyl nicotinate.
PubMed: Assessment of topical non-steroidal anti-inflammatory drugs.
PubMed: Effect of the vehicle on non-immunologic immediate contact reactions.
PubMed: Duration of inhibition of non-immunologic immediate contact reactions by acetylsalicylic acid.
PubMed: Cutaneous responses to topical methyl nicotinate in black, oriental, and caucasian subjects.
PubMed: Systemic effect of ultraviolet irradiation on non-immunologic immediate contact reactions to benzoic acid and methyl nicotinate.
PubMed: Systemic symptoms associated with a rubefacient.
PubMed: Topical non-steroidal anti-inflammatory drugs inhibit non-immunologic immediate contact reactions.
PubMed: Non-ionic surfactant effects on hairless mouse skin permeability characteristics.
PubMed: Dichloroacetate derivatives. Metabolic effects and pharmacodynamics in normal rats.
PubMed: Terfenadine does not inhibit non-immunologic contact urticaria.
PubMed: Acetylsalicylic acid inhibits non-immunologic contact urticaria.
PubMed: Solute transport resistance at water-oil interfaces.
PubMed: Percutaneous absorption in the aged.
PubMed: [Diurnal dependence of skin reactions in the administration of external substances].
PubMed: Pharmacological studies on nonimmunologic contact urticaria in guinea pigs.
PubMed: Long refractory period after one application of nonimmunologic contact urticaria agents to the guinea pig ear.
PubMed: Prostaglandins and nicotinate-provoked increase in cutaneous blood flow.
PubMed: Spatial variability of vasodilatation in human forearm skin.
PubMed: Species specificity of nonimmunologic contact urticaria: guinea pig, rat, and mouse.
PubMed: Are there age and racial differences to methyl nicotinate-induced vasodilatation in human skin?
PubMed: Percutaneous absorption in man: a kinetic approach.
PubMed: An animal model for nonimmunologic contact urticaria.
PubMed: Skin penetration of nicotinic acid, methyl nicotinate, and butyl nicotinate in the guinea pig--comparison of in vivo and excised skin, and the effects of four dermatologic conditions.
PubMed: Pharmacodynamic measurements of methyl nicotinate percutaneous absorption.
PubMed: Noninvasive assessments of the percutaneous absorption of methyl nicotinate in humans.
PubMed: Noninvasive assessment of local nicotinate pharmacodynamics by photoplethysmography.
PubMed: Kinetics and thermodynamics of interfacial transfer.
PubMed: Rapid radial transport of methyl nicotinate in the dermis.
PubMed: [Studies on the permeability of human skin to nicotinic acid, methyl nicotinate and butyl nicotinate. -- with emphasis on the influence of liquid vehicles and that of water immersion (author's transl)].
PubMed: The pH dependence of xanthine oxidase catalysis in basic solution.
PubMed: Percutaneous absorption: in vivo experiments.
PubMed: Inhibition of adenosine 3',5'-monophosphate phosphodiesterase by nicotinamide and its homologues in vitro.
PubMed: Proceedings: The effect of thermodynamic activity on the percutaneous absorption of methyl nicotinate from water glycerol mixtures.
PubMed: The effect of glycerol on the percutaneous absorption of methyl nicotinate.
PubMed: The metabolism of niacytin in the rat. Trigonelline as a major metabolite of niacytin in the urine.
PubMed: The rate of absorption and duration of action of four different solutions of methyl nicotinate.
PubMed: [Crystal reactions in methyl nicotinate].
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