beta-elemene
(1R,2R,4S)-1-methyl-2,4-di(prop-1-en-2-yl)-1-vinylcyclohexane
 
Notes:
None found
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(1R,2R,4S)-1-ethenyl-1-methyl-2,4-di(prop-1-en-2-yl)cyclohexane (Click)
CAS Number: 33880-83-0Picture of molecule
ECHA EINECS - REACH Pre-Reg: 251-713-0
Nikkaji Web: J308.554F
XlogP3-AA: 6.10 (est)
Molecular Weight: 204.35628000
Formula: C15 H24
NMR Predictor: Predict (works with chrome or firefox)
Category: flavor and fragrance agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
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Perfumer and Flavorist: Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
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Physical Properties:
Appearance: colorless to yellow clear liquid (est)
Assay: 92.00 to 100.00 % 
Food Chemicals Codex Listed: No
Boiling Point: 251.00 to  253.00 °C. @ 760.00 mm Hg (est)
Vapor Pressure: 0.027600 mm/Hg @ 25.00 °C.
Flash Point: 209.00 °F. TCC ( 98.30 °C. ) (est)
logP (o/w): 5.772 (est)
Soluble in:
 alcohol
 water, 0.01172 mg/L @ 25 °C (est)
Insoluble in:
 water
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Organoleptic Properties:
Odor Type: herbal
Odor Strength: medium
 herbal  waxy  fresh  
Odor Description:
at 100.00 %. 
herbal waxy fresh
  
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Cosmetic Information:
None found
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Suppliers:
Isobionics
Natural Beta Elemene
Odor: characteristic
Use: Beta Eelemene can be used as a building block in the flavour and fragrance industry Isobionics offers Beta Elemene with a minimal purity of 98% Appearance: clear colourless liquid
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: flavor and fragrance agents
Recommendation for beta-elemene usage levels up to:
  4.0000 % in the fragrance concentrate.
 
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Safety References:
EPI System: View
EPA Substance Registry Services (TSCA): 33880-83-0
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 9859094
National Institute of Allergy and Infectious Diseases: Data
 (1R,2R,4S)-1-ethenyl-1-methyl-2,4-di(prop-1-en-2-yl)cyclohexane
Chemidplus: 0033880830
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References:
 (1R,2R,4S)-1-ethenyl-1-methyl-2,4-di(prop-1-en-2-yl)cyclohexane
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 9859094
Pubchem (sid): 134998583
Flavornet: 33880-83-0
Pherobase: View
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
HMDB (The Human Metabolome Database): Search
FooDB: FDB014577
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
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Potential Blenders and core components note
 
For Odor
floral
alpha-hexyl cinnamaldehydeFL/FR
 octyl acetateFL/FR
herbal
 butyl levulinateFL/FR
(-)-alpha-cubebene 
 
For Flavor
 
No flavor group found for these
(-)-alpha-cubebene 
 octyl acetateFL/FR
herbal
 butyl levulinateFL/FR
waxy
alpha-hexyl cinnamaldehydeFL/FR
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 allamanda cathartica linn. flower oil brazil @ 0.50%
Data  GC  Search Trop  Picture
 allspice plant
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 amyris wood oil @ 0.10%
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 angelica seed oil CO2 extract @ trace%
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 anise seed oil
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 anise seed oil star china @ 0.04%
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 anise star anise fruit
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 armoise oil morocco @ 1.7%
Data  GC  Search Trop  Picture
 baccharis coridifolia oil argentina @ 1.20%
Data  GC  Search Trop  Picture
 backhousia citriodora f. muell. leaf oil @ 0.10%
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 basil absolute sweet @ 0.48%
Data  GC  Search Trop  Picture
 basil flower oil sweet @ 0.73%
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 basil leaf oil sweet (ocimum basilicum) @ 0.90%
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 basil oil
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 basil oil CO2 sweet @ trace%
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 basil oil sweet @ 0.96%
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 basil oil sweet egypt @ 0.11%
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 basil oil sweet poland @ 0.86%
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 basil oil var. glabratum turkey @ 0.30%
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 basil plant
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 basil shoot oil
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 bay laurel leaf oil
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 bay laurel plant
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 bay leaf oil @ 0.00-0.20%
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 bergamot mint oil @ 0.0-0.3%
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 burdock root
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 cabocla flower oil brazil @ 1.70%
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 cajuput oil vietnam @ 0.3%
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 calamus leaf oil @ 0.79%
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 calamus rhizome oil @ 0.48%
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 calamus root oil @ 0.29%
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 calamus root oil mongolia @ 0.50%
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 callitris intratropica wood oil australia @ 0.50%
Data  GC  Search Trop  Picture
 camel grass oil @ trace%
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 cananga leaf oil @ 1.4%
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 caraway oil
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 caraway seed oil
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 carrot plant
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 carrot plant
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 cascarilla bark oil @ 1.63%
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 cassis bud oil @ trace-0.14%
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 cedrela wood oil @ 0.10%
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 celery leaf
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 celery leaf oil
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 celery seed
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 celery seed oil
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 celery seed oil CO2 extract india @ 0.04%
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 celery seed oil india @ 0.07%
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 champaca concrete @ 0.58%
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 cinnamomum fragrans baillon leaf oil madagascar @ trace%
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 cinnamon ceylon cinnamon leaf
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 cinnamon leaf oil ceylon @ 0.34%
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 citronella oil ceylon @ 1.10%
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 citronella oil china @ 2.80%
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 citronella oil java @ 1.96%
Data  GC  Search Trop  Picture
 clary sage oil spain @ 0.43%
Data  GC  Search Trop  Picture
 croton cajucara benth. leaf oil brazil @ 0.70%
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 croton flavens l. (welensali) leaf oil curacao @ 0.80%
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 cumin seed
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 curcuma amada roxb. rhizome oil india @ 2.80%
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 curry fruit oil india @ <0.05%
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 curry leaf oil india @ 0.20%
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 curry wood leaf oil australia @ 0.60%
Data  GC  Search Trop  Picture
 dill seed
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 echinophora cinerea oil iran @ 0.10%
Data  GC  Search Trop  Picture
 galangal root oil @ 0.30%
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 geranium rose-scented oil (pelargonium spp.) cuba @ 0.70%
Data  GC  Search Trop  Picture
 ginger rhizome
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 ginger rhizome oil
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 ginger root oil brazil @ 0.90%
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 ginger root oil china @ 0.81%
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 ginger root oil CO2 extract australia @ 0.20%
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 grapefruit oil california @ 0.03%
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 horsemint shoot
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 hyptis spicigera lam. oil mali @ 0.10-0.20%
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 hyssop plant
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 juniper berry oil @ 1.10%
Data  GC  Search Trop  Picture
 kachur oil @ 3.30%
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 laurel leaf oil turkey @ 0.60%
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 lemon balm shoot
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 lemon oil
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 lemongrass oil @ 0.13%
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 lemongrass oil @ 0.15%
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 lime oil CO2 extract mexico @ 0.13%
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 lime oil distilled mexico @ trace%
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 lime oil distilled peru @ 0.06%
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 lime oil expressed florida @ 0.1%
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 lovage root
Search Trop  Picture
 mandarin
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 mandarin fruit
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 mandarin oil uruguay @ 0.01%
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 manuka var. eximium oil australia @ 0.10%
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 manuka var. scoparium oil new zealand @ 0.55%
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 marsypianthes chamaedrys (vahl) kuntze oil brazil @ 2.50%
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 mikan peel oil @ trace%
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 mikania cordata (burm. f.) b.l. robinson var. cordata leaf oil france @ 2.10%
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 mint
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 ocimum gratissimum l. oil brazil @ 2.03%
Data  GC  Search Trop  Picture
 orange
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 orange fruit
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 orange peel oil bitter china @ trace%
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 orange peel oil bitter italy @ 0.01%
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 orange pericarp oil
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 oregano plant
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 oregano shoot oil
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 orthodon dianthera maxim. oil vietnam @ 0.20%
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 palmarosa oil @ 0.10%
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 parsley leaf
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 parsley leaf oil @ 1.59%
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 parsley leaf oil cuba @ 0.61%
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 patchouli oil @ 6.08%
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 pepper black pepper fruit
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 pepper black pepper fruit oil
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 pepper oil black india @ trace%
Data  GC  Search Trop  Picture
 pepper tree berry oil @ 0.52%
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 pepper tree leaf oil @ 0.01%
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 peppermint oil CO2 extract @ 0.90%
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 persea americana mill. fruit oil cuba @ trace%
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 petitgrain combava oil @ trace%
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 petitgrain grapefruit oil @ trace%
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 petitgrain mandarin oil @ 1.28%
Data  GC  Search Trop  Picture
 petitgrain sweet oil @ 0.03%
Data  GC  Search  Picture
 phlomis fruticosa l. flower oil greece @ 0.30%
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 phoebe oil brazil @ 0.44%
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 pine needle oil dwarf @ 4.81%
Data  GC  Search Trop  Picture
 pinus sylvestris l. needle oil estonia @ 0.30%
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 piper cernum vell. var. cernum yuncker leaf oil brazil @ 0.60%
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 plectranthus glandulosus hook f. leaf oil cameroon @ 0.10%
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 polyalthia australis (benth.) jessup leaf oil australia @ 1.00%
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 potato
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 ravintsara leaf oil @ 0.63%%
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 rose oil otto bulgaria @ 0.08%
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 rosemary sap
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 rosemary shoot
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 salvia atropatana bunge oil iran @ 1.40%
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 savin oil @ 0.62%
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 sideritis montana l. oil bulgaria @ 2.00%
Data  GC  Search Trop  Picture
 sideritis scardica l. oil bulgaria @ 0.50%
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 spearmint leaf
Search Trop  Picture
 spearmint oil
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 spearmint oil america @ 0.06-0.23%
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 sugandha kokila berry oil @ 0.30%
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 tamarind fruit oil
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 tamarind seed oil
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 tansy oil marocco @ 0.40%
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 thevetia peruviana (pers.) k. schum. flower oil brazil @ 0.50%
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 turmeric root oil vietnam @ 0.05%
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 valerian root oil @ 0.1-0.4%
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 valerian root oil CO2 extract china @ 0.07%
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 vassoura oil @ 1.60%
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 water mint shoot
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 xylopia aromatica (lam.) mart. leaf oil cuba @ 0.20%
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 yarrow leaf oil @ 0.60%
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 yarrow oil @ trace%
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 yarrow oil greece @ trace%
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 yuzu leaf oil @ 0.19-0.39%
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 zanthoxylum bracchyacanthum l. leaf oil australia @ 0.10%
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 zanthoxylum nitidum l. leaf oil australia @ 2.00%
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 zanthoxylum ovalifolium l. leaf oil australia @ 0.60%
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Synonyms   Articles   Notes   Search   Top
Synonyms:
(1alpha,2beta,4beta)-1-ethenyl-1-methyl-2,4-bis(1-methyl ethenyl) cyclohexane
(1R,2R,4S)-1-ethenyl-1-methyl-2,4-bis(1-methyl ethenyl) cyclohexane
(1R,2R,4S)-1-ethenyl-1-methyl-2,4-di(prop-1-en-2-yl)cyclohexane
(1alpha,2,4)-1-methyl-2,4-bis(methyl vinyl)-1-vinyl cyclohexane
(±)-b-elemene
(1R,2R,4S)-1-methyl-2,4-di(prop-1-en-2-yl)-1-vinylcyclohexane
b-elemene
 cyclohexane, 1-ethenyl-1-methyl-2,4-bis(1-methylethenyl)-, (1R,2R,4S)-
rel-(1R,2R,4S)-2,4-diisopropenyl-1-methyl-1-vinylcyclohexane
Synonyms   Articles   Notes   Search   Top
Articles:
PubMed: Isolation of jasmonate-induced sesquiterpene synthase of rice: Product of which has an antifungal activity against Magnaporthe oryzae.
PubMed: In vitro antibacterial activity of Libanotis montana essential oil in combination with conventional antibiotics.
PubMed: Chemical compositions and antimicrobial activity of the essential oils of Hornstedtia havilandii (Zingiberaceae).
PubMed: β-elemene reverses the drug resistance of lung cancer A549/DDP cells via the mitochondrial apoptosis pathway.
PubMed: More insight into the chemical composition of Greek propolis; differences and similarities with Turkish propolis.
PubMed: β-Elemene inhibits the metastasis of B16F10 melanoma cells by downregulation of the expression of uPA, uPAR, MMP-2, and MMP-9.
PubMed: Chemical composition, antimicrobial and antioxidant activities of essential oil from Ampelopsis megalophylla.
PubMed: Chemical composition of essential oils from the leaves and stem barks of Vietnamese species of Polyalthia harmandiiPolyalthia jucunda and Polyalthia thorelii.
PubMed: Constituents of essential oils from the leaves, stem barks and resins of Canarium parvum Leen., and Canarium tramdenanum Dai et Yakovl. (Burseracea) grown in Vietnam.
PubMed: The effect of beta-elemene on alpha-tubulin polymerization in human hepatoma HepG2 cells.
PubMed: Essential oils composition of croton species from the Amazon.
PubMed: Essential oil composition of Aegle marmelos (L.) Correa: chemotypic and seasonal variations.
PubMed: β-Elemene, a compound derived from Rhizoma zedoariae, reverses multidrug resistance mediated by the ABCB1 transporter.
PubMed: The effects of β-elemene on the expression of mTOR, HIF-1A, survivin in lung adenocarcinoma A549 cell.
PubMed: Quantitative Analysis and Discrimination of Steamed and Non-Steamed Rhizomes of Curcuma wenyujin by GC-MS and HPLC.
PubMed: [Synergistic effect of beta-elemene injection combined paclitaxel injection on human breast cancer MB-468 cells: an in vitro study].
PubMed: Formulation design, preparation, and in vitro and in vivo characterizations of β-Elemene-loaded nanostructured lipid carriers.
PubMed: [Potential applications of beta-elemene in anti-atherosclerosis and anti-restenosis].
PubMed: β-Elemene enhances susceptibility to cisplatin in resistant ovarian carcinoma cells via downregulation of ERCC-1 and XIAP and inactivation of JNK.
PubMed: Zedoary oil (Ezhu You) inhibits proliferation of AGS cells.
PubMed: 13,14-bis(cis-3,5-dimethyl-1-piperazinyl)-β-elemene, a novel β-elemene derivative, shows potent antitumor activities via inhibition of mTOR in human breast cancer cells.
PubMed: Chemical composition and antimicrobial activity of three essential oils from Curcuma wenyujin.
PubMed: β-elemene decreases cell invasion by upregulating E-cadherin expression in MCF-7 human breast cancer cells.
PubMed: β -Elemene-Attenuated Tumor Angiogenesis by Targeting Notch-1 in Gastric Cancer Stem-Like Cells.
PubMed: Characterization of Chemical Composition of Pericarpium Citri Reticulatae Volatile Oil by Comprehensive Two-Dimensional Gas Chromatography with High-Resolution Time-of-Flight Mass Spectrometry.
PubMed: The cytotoxic effect of β-elemene against malignant glioma is enhanced by base-excision repair inhibitor methoxyamine.
PubMed: Chemical composition and anti-Trypanosoma cruzi activity of essential oils obtained from leaves of Xylopia frutescens and X. laevigata (Annonaceae).
PubMed: The Role of E3 Ubiquitin Ligase Cbl Proteins in β-Elemene Reversing Multi-Drug Resistance of Human Gastric Adenocarcinoma Cells.
PubMed: [Treatment of hepatic cancer in mice by beta-elemene combined DC/Dribble vaccine: an immune mechanism research].
PubMed: Analysis of Cleistopholis patens leaf and trunk bark oils using combined GC- flame ionisation detection, GC-retention index, GC-MS and (13) C-NMR.
PubMed: Phytochemical diversity of Murraya koenigii (L.) Spreng. from Western Himalaya.
PubMed: β-Elemene promotes cisplatin-induced cell death in human bladder cancer and other carcinomas.
PubMed: Beta-elemene blocks epithelial-mesenchymal transition in human breast cancer cell line MCF-7 through Smad3-mediated down-regulation of nuclear transcription factors.
PubMed: Antiproliferative and apoptotic effects of β-elemene on human hepatoma HepG2 cells.
PubMed: β-Elemene and taxanes synergistically induce cytotoxicity and inhibit proliferation in ovarian cancer and other tumor cells.
PubMed: Chemical composition and anticancer, antiinflammatory, antioxidant and antimalarial activities of leaves essential oil of Cedrelopsis grevei.
PubMed: [The pharmacokinetics of long-circulating beta-elemene liposomes].
PubMed: Sensitization of lung cancer cells to cisplatin by β-elemene is mediated through blockade of cell cycle progression: antitumor efficacies of β-elemene and its synthetic analogs.
PubMed: Antimicrobial Potential and Chemical Characterization of Serbian Liverwort (Porella arboris-vitae): SEM and TEM Observations.
PubMed: [Study on the chemical components, antimicrobial and antitumor activities of the essential oil from the leaves of Zanthoxylum avicennae].
PubMed: Enhancement of cisplatin-induced apoptosis by β-elemene in resistant human ovarian cancer cells.
PubMed: Anticancer activity of β-Elemene and its synthetic analogs in human malignant brain tumor cells.
PubMed: Anti-Lung-Cancer Activity and Liposome-Based Delivery Systems of β-Elemene.
PubMed: Antimicrobial activity of selected essential oils against cariogenic bacteria.
PubMed: β-elemene inhibits the proliferation of T24 bladder carcinoma cells through upregulation of the expression of Smad4.
PubMed: Chemotaxonomical markers in essential oil of Murraya koenigii.
PubMed: Synergistic effects of Endostar combined with β-elemene on malignant ascites in a mouse model.
PubMed: Systematic review of β-elemene injection as adjunctive treatment for lung cancer.
PubMed: Identification of insecticidal constituents of the essential oil of Curcuma wenyujin rhizomes active against Liposcelis bostrychophila Badonnel.
PubMed: Tangy scent in Toona sinensis (Meliaceae) leaflets: isolation, functional characterization, and regulation of TsTPS1 and TsTPS2, two key terpene synthase genes in the biosynthesis of the scent compound.
PubMed: Study on the volatile oil contents of Annona glabra L., Annona squamosa L., Annona muricata L. and Annona reticulata L., from Vietnam.
PubMed: Chemical composition and biological activities of the essential oils from Duguetia lanceolata St. Hil. barks.
PubMed: β-elemene induces glioma cell apoptosis by downregulating survivin and its interaction with hepatitis B X-interacting protein.
PubMed: β-Elemene induces apoptosis in human renal-cell carcinoma 786-0 cells through inhibition of MAPK/ERK and PI3K/Akt/ mTOR signalling pathways.
PubMed: Furanodiene induces endoplasmic reticulum stress and presents antiproliferative activities in lung cancer cells.
PubMed: β-elemene acts as an antitumor factor and downregulates the expression of survivin, Bcl-xL and Mta-1.
PubMed: Chemical composition, antimicrobial, antioxidant and cytotoxic activity of the essential oil from the leaves of Acanthopanax leucorrhizus (Oliv.) Harms.
PubMed: Relation between chemical composition or antioxidant activity and antihypertensive activity for six essential oils.
PubMed: β-elemene effectively suppresses the growth and survival of both platinum-sensitive and -resistant ovarian tumor cells.
PubMed: Anti-cancer properties of terpenoids isolated from Rhizoma Curcumae--a review.
PubMed: Differences in the volatile compositions of ginseng species (Panax sp.).
PubMed: Volatiles from Michelia champaca flower: comparative analysis by simultaneous distillation-extraction and solid phase microextraction.
PubMed: HIF-1α induced by β-elemene protects human osteosarcoma cells from undergoing apoptosis.
PubMed: Natural product studies of U.S. endangered plants: volatile components of Lindera melissifolia (Lauraceae) repel mosquitoes and ticks.
PubMed: β-Elemene radiosensitizes lung cancer A549 cells by enhancing DNA damage and inhibiting DNA repair.
PubMed: Evaluation of the antinociceptive, anti-inflammatory and gastric antiulcer activities of the essential oil from Piper aleyreanum C.DC in rodents.
PubMed: Reversion of multidrug resistance in a chemoresistant human breast cancer cell line by β-elemene.
PubMed: Potential role of β-elemene on histone H1 in the H22 ascites hepatoma cell line.
PubMed: Volatiles from Magnolia grandiflora flowers: comparative analysis by simultaneous distillation-extraction and solid phase microextraction.
PubMed: The leaf essential oils of five Vietnamese Desmos species (Annonaceae).
PubMed: Chemical and biological analyses of the essential oils and main constituents of Piper species.
PubMed: Down-regulation of survivin and hypoxia-inducible factor-1 α by β-elemene enhances the radiosensitivity of lung adenocarcinoma xenograft.
PubMed: Β-elemene inhibits Hsp90/Raf-1 molecular complex inducing apoptosis of glioblastoma cells.
PubMed: β-Elemene induces apoptosis as well as protective autophagy in human non-small-cell lung cancer A549 cells.
PubMed: Applications of nanoparticles in herbal medicine: zedoary turmeric oil and its active compound β-elemene.
PubMed: [Analysis of content changes of volatile oil and beta-elemene in oil in Sarcandrae].
PubMed: Chemical composition of the essential oil from basil (Ocimum basilicum Linn.) and its in vitro cytotoxicity against HeLa and HEp-2 human cancer cell lines and NIH 3T3 mouse embryonic fibroblasts.
PubMed: Synergistic antitumor effect of β-elemene and etoposide is mediated via induction of cell apoptosis and cell cycle arrest in non-small cell lung carcinoma cells.
PubMed: Fractionation of volatile constituents from curcuma rhizome by preparative gas chromatography.
PubMed: California Lomatiums, Part X. Comparison of composition of the hydrodistilled oils from two subspecies of Lomatium mohavense.
PubMed: Cbl-regulated Akt and ERK signals are involved in β-elemene-induced cell apoptosis in lung cancer cells.
PubMed: Changes in volatile compound composition of Antrodia camphorata during solid state fermentation.
PubMed: [GC-MS analysis of volatile oil of olibanum].
PubMed: Anti-cancer natural products isolated from chinese medicinal herbs.
PubMed: The compositions of volatiles and aroma-active compounds in dried omija fruits (Schisandra chinensis Baillon) according to the cultivation areas.
PubMed: Downregulation effects of beta-elemene on the levels of plasma endotoxin, serum TNF-alpha, and hepatic CD14 expression in rats with liver fibrosis.
PubMed: [GC-MS analysis of essential oil from root of Angelica dahurica cv. Qibaizhi].
PubMed: P21 (waf1/cip1) is required for non-small cell lung cancer sensitive to Gefitinib treatment.
PubMed: Protection of endothelial cells, inhibition of neointimal hyperplasia by β-elemene in an injured artery.
PubMed: β-Elemene-induced autophagy protects human gastric cancer cells from undergoing apoptosis.
PubMed: β-elemene inhibits proliferation of human glioblastoma cells through the activation of glia maturation factor β and induces sensitization to cisplatin.
PubMed: Chemical composition, antimicrobial and antioxidant activities of essential oil from Gnaphlium affine.
PubMed: Volatile constituent distribution of Prangos coryombosa Boiss at two stages of growth.
PubMed: Comparative volatile oil composition of four Ocimum species from northern India.
PubMed: Chemical composition and antibacterial activity of the essential oil of Drimys granadensis L.f. leaves from Colombia.
PubMed: Composition of the essential oil of Bidens tripartita L. roots and its antibacterial and antifungal activities.
PubMed: Essential oil composition of Vismia macrophylla leaves (Guttiferae).
PubMed: [Comparison of content of curdione, curcumol, germacrone and beta-elemene in different varieties of vinegar backed Rhizoma Curcuma].
PubMed: Caryophyllene oxide-rich essential oils of Lithuanian Artemisia campestris ssp. campestris and their toxicity.
PubMed: β-Elemene piperazine derivatives induce apoptosis in human leukemia cells through downregulation of c-FLIP and generation of ROS.
PubMed: Chemical composition and antimicrobial activity of the essential oils of Anthospermum emirnense and Anthospermum perrieri (Rubiaceae).
PubMed: Amelioration of experimental autoimmune encephalomyelitis by β-elemene treatment is associated with Th17 and Treg cell balance.
PubMed: Preparation and characterization of β-elemene-loaded microemulsion.
PubMed: Efficient synthesis of the anticancer β-elemene and other bioactive elemanes from sustainable germacrone.
PubMed: ß-Elemene inhibits proliferation of human glioblastoma cells and causes cell-cycle G0/G1 arrest via mutually compensatory activation of MKK3 and MKK6.
PubMed: GC-MS analysis of headspace and liquid extracts for metabolomic differentiation of citrus Huanglongbing and zinc deficiency in leaves of 'Valencia' sweet orange from commercial groves.
PubMed: Evaluation of cisplatin in combination with β-elemene as a regimen for prostate cancer chemotherapy.
PubMed: Preparation, characterization and relative bioavailability of oral elemene o/w microemulsion.
PubMed: [Mechanism study of beta-elemene derivative (ET) in NB4 cell on apoptosis induction].
PubMed: Antineoplastic effect of beta-elemene on prostate cancer cells and other types of solid tumour cells.
PubMed: Beta-elemene inhibits melanoma growth and metastasis via suppressing vascular endothelial growth factor-mediated angiogenesis.
PubMed: [HPLC determination of six components in zedoary turmeric oil and its related injections].
PubMed: [Effects of beta-elemene on proliferation and apoptosis of human multiple myeloma cell RPMI-8226].
PubMed: Preparative isolation and purification of six volatile compounds from essential oil of Curcuma wenyujin using high-performance centrifugal partition chromatography.
PubMed: Downregulation of IL-17 and IFN-gamma in the optic nerve by beta-elemene in experimental autoimmune encephalomyelitis.
PubMed: Exploiting cyanobacterial P450 pathways.
PubMed: [Analysis on chemical components of volatile oil and determination of thymoquinone from seed of Nigella glandulifera].
PubMed: [beta-elemene enhances aclarubicin-induced apoptotic effect in HL-60 cells and its mechanism.].
PubMed: Essential oils from two Lantana species with antimycobacterial activity.
PubMed: Different isolation methods for determination of composition of volatiles from Nigella damascena L. seeds.
PubMed: Volatile constituents of Ocimum minimum herb cultivated in Portugal.
PubMed: Essential oil composition from two species of Piperaceae family grown in Colombia.
PubMed: Seasonal variation and bioactivity in the leaf oil of Liriodendron tulipifera growing in Huntsville, Alabama.
PubMed: beta-Elemene, a novel plant-derived antineoplastic agent, increases cisplatin chemosensitivity of lung tumor cells by triggering apoptosis.
PubMed: [Beta-elemene inhibits expression of ANG II and RhoA/ROCK signaling in hepatic stellate cells].
PubMed: ANG II-AT1 receptor pathway is involved in the anti-fibrotic effect of beta-elemene.
PubMed: Essential oil compositions of three Lantana species from Monteverde, Costa Rica.
PubMed: Radioactive synthesis and biodistribution study of beta-elemene-99mTc(CO)3 conjugates.
PubMed: Antiulcerogenic and anti-inflammatory activities of the essential oil from Pterodon emarginatus seeds.
PubMed: Anti-cancer properties of Nigella spp. essential oils and their major constituents, thymoquinone and beta-elemene.
PubMed: Synthesis and in vitro anti-proliferative activity of beta-elemene monosubstituted derivatives in HeLa cells mediated through arrest of cell cycle at the G1 phase.
PubMed: Validation of a sensitive gas chromatographic-mass spectrometric method for the simultaneous determination of beta-elemene and beta-elemenal in human plasma.
PubMed: [Effect of beta-elemene on the proliferation, migration and RhoA expression of hepatic stellate cells induced by angiotensin II].
PubMed: Terpene biosynthesis in glandular trichomes of hop.
PubMed: Morphological, genetic, and chemical polymorphism of Curcuma kwangsiensis.
PubMed: Antibacterial terpenes from the oleo-resin of Commiphora molmol (Engl.).
PubMed: N-(beta-Elemene-13-yl)tryptophan methyl ester induces apoptosis in human leukemia cells and synergizes with arsenic trioxide through a hydrogen peroxide dependent pathway.
PubMed: Anti-tumor effect of beta-elemene in glioblastoma cells depends on p38 MAPK activation.
PubMed: [Effect of traditional Chinese medicine on quality of life and survival period in patients with progressive gastric cancer].
PubMed: Ab initio analysis of the Cope rearrangement of germacrane sesquiterpenoids.
PubMed: The influence of different nutrient levels on insect-induced plant volatiles in Bt and conventional oilseed rape plants.
PubMed: Bioactivity and chemical composition of the leaf essential oils of Zanthoxylum rhoifolium and Zanthoxylum setulosum from Monteverde, Costa Rica.
PubMed: Volatile components from the roots of Solanum pseudocapsicum.
PubMed: Interception of the enzymatic conversion of farnesyl diphosphate to 5-epi-aristolochene by using a fluoro substrate analogue: 1-fluorogermacrene A from (2E,6Z)-6-fluorofarnesyl diphosphate.
PubMed: [Extraction and identification of volatile constituents in the flowers of Aglaia odorata Lour].
PubMed: The volatile constituents analysis of Eremostachys macrophylla Montbr. & Auch. from Iran.
PubMed: In vitro combination characterization of the new anticancer plant drug beta-elemene with taxanes against human lung carcinoma.
PubMed: The rice (E)-beta-caryophyllene synthase (OsTPS3) accounts for the major inducible volatile sesquiterpenes.
PubMed: [GC-MS analysis of essential oil from anthodiums of Chrysanthemum morifolium processed by microwave-airflow and steam calefaction].
PubMed: Immunotherapeutic effects on murine pancreatic carcinoma by β-elemene combined with dendritic cells modified with genes encoding interleukin-23.
PubMed: Essential oil constituents from Japanese and Indian Curcuma aromatica rhizomes.
PubMed: Effect of ginseng saponin, arsenic trioxide, beta-elemene combined with CTX on telomere-telomerase system in K562 cell line.
PubMed: [Research of beta-elemene interventional treatment on VX2 carcinoma transplanted on kidney in rabbits].
PubMed: Simultaneous determination of 11 characteristic components in three species of Curcuma rhizomes using pressurized liquid extraction and high-performance liquid chromatography.
PubMed: [Immunotherapeutic effects of beta-elemene combined with interleukin-23 gene-modified dendritic cells on murine pancreatic carcinoma].
PubMed: Analysis of volatile components of Curcuma sichuanensis X. X. Chen by gas chromatography-mass spectrometry.
PubMed: From terpenoids to aliphatic acids: further evidence for late-instar switch in osmeterial defense as a characteristic trait of swallowtail butterflies in the tribe papilionini.
PubMed: Screening and analysis of bioactive compounds in traditional Chinese medicines using cell extract and gas chromatography-mass spectrometry.
PubMed: Optimization of GC-MS conditions based on resolution and stability of analytes for simultaneous determination of nine sesquiterpenoids in three species of Curcuma rhizomes.
PubMed: [Radiosensitization of beta-elemene on VX2 carcinoma transplanted on kidney in rabbits in vivo].
PubMed: [Analysis of volatile constituents in leaves of three cypress species by gas chromatography/mass spectrometry].
PubMed: [Study on pharmacokinetics of PVP coated beta-elemene liposome in rats].
PubMed: The synthesis and anti-proliferative effects of beta-elemene derivatives with mTOR inhibition activity.
PubMed: Assessing the quality of RCTs on the effect of beta-elemene, one ingredient of a Chinese herb, against malignant tumors.
PubMed: Characterization and body distribution of beta-elemene solid lipid nanoparticles (SLN).
PubMed: Essential oil analysis and anticancer activity of leaf essential oil of Croton flavens L. from Guadeloupe.
PubMed: Headspace solid-phase microextraction-gas chromatography--mass spectrometry analysis of the volatile compounds of Evodia species fruits.
PubMed: The pharmacokinetics of a novel anti-tumor agent, beta-elemene, in Sprague-Dawley rats.
PubMed: [Excretion of beta-elemene from rat respiratory tracts].
PubMed: Antiproliferative effect of beta-elemene in chemoresistant ovarian carcinoma cells is mediated through arrest of the cell cycle at the G2-M phase.
PubMed: Antitumor effect of beta-elemene in non-small-cell lung cancer cells is mediated via induction of cell cycle arrest and apoptotic cell death.
PubMed: Analysis of leaf surface sesquiterpenes in potato varieties.
PubMed: Application of multidimensional gas chromatography to the enantioselective characterisation of the essential oil of Eupatorium buniifolium Hooker et Arnott.
PubMed: Isogermacrene A, a proposed intermediate in sesquiterpene biosynthesis.
PubMed: Essential oil yield and quality of methyl eugenol rich Ocimum tenuiflorum L.f. (syn. O. sanctum L.) grown in south India as influenced by method of harvest.
PubMed: [Reversal of resistance to adriamycin in human breast cancer cell line MCF-7/ADM by beta-elemene].
PubMed: [Effects of arsenic trioxide, ginseng saponin and beta-elemene on telomere-telomerase system in K562 cell line].
PubMed: Composition and functional properties of the essential oil of amazonian basil, Ocimum micranthum Willd., Labiatae in comparison with commercial essential oils.
PubMed: Volatile constituents and key odorants in leaves, buds, flowers, and fruits of Laurus nobilis L.
PubMed: Sesquiterpenes of the liverwort Scapania undulata.
PubMed: [Quantum chemistry Ab initio calculation of vibration spectrum of beta-elemene].
PubMed: GC-MS analysis of essential oil of Shorea robusta bast.
PubMed: Interspecific variation in terpenoid composition of defensive secretions of European Reticulitermes termites.
PubMed: Differential volatile emissions and salicylic acid levels from tobacco plants in response to different strains of Pseudomonas syringae.
PubMed: Essential oil from fruit of Peucedanum tauricum Bieb.
PubMed: [Constituents analysis on volatile oil of Pogostemon cablin from different collection time cultivated in Hainan].
PubMed: Monitoring and fast detection of mycotoxin-producing fungi based on headspace solid-phase microextraction and headspace sorptive extraction of the volatile metabolites.
PubMed: [Effect of PIC-BE on the expression of MDR-1 and bcl-2 genes in a multidrug resistance cell variant K562/ADM].
PubMed: [Supercritical fluid extraction of beta-elemene under lower pressure].
PubMed: [Determination of elemenyl piperidine salt in water by capillary gas chromatography].
PubMed: Aroma compound analysis of Piper nigrum and Piper guineense essential oils from Cameroon using solid-phase microextraction-gas chromatography, solid-phase microextraction-gas chromatography-mass spectrometry and olfactometry.
PubMed: Volatile sesquiterpene hydrocarbons characteristic for Penicillium roqueforti strains producing PR toxin.
PubMed: Germacrene A is a product of the aristolochene synthase-mediated conversion of farnesylpyrophosphate to aristolochene.
PubMed: Seco-sethukarailin, a novel diterpenoid from the soft coral Sinularia dissecta.
PubMed: Effect of the essential oil from the flowers of Magnolia sieboldii on the lipopolysaccharide-induced production of nitric oxide and prostaglandin E2 by rat peritoneal macrophages.
PubMed: [beta-elemene induces apoptosis of K562 leukemia cells].
PubMed: [Preliminary study on the antitumor immuno-protective mechanism of beta-elemene].
PubMed: Germacrenes from fresh costus roots.
PubMed: Essential oils from Azorean Laurus azorica.
PubMed: A chemotaxonomic investigation of volatile constituents in Stachys subsect. Swainsonianeae (Labiatae).
PubMed: [Pharmacokinetics and disposition of beta-elemene in rats].
PubMed: Biosynthesis of germacrene A carboxylic acid in chicory roots. Demonstration of a cytochrome P450 (+)-germacrene a hydroxylase and NADP+-dependent sesquiterpenoid dehydrogenase(s) involved in sesquiterpene lactone biosynthesis.
PubMed: [Studies on metabolite of beta-elemene in rat bile].
PubMed: Essential oil analysis of Eusteralis deccanensis Panigrahi (Lamiaceae).
PubMed: Chemical variability of the volatile metabolites from the Caribbean corals of the genus Gorgonia.
PubMed: Synthesis of sesquiterpene derivatives as potential antitumor agents; elemane derivatives.
PubMed: Cytotoxic terpenoids from the Formosan soft coral Nephthea brassica.
PubMed: (+)-Germacrene A biosynthesis . The committed step in the biosynthesis of bitter sesquiterpene lactones in chicory
PubMed: Terpenoid composition of the wound-induced bark exudate of Commiphora tenuis from Ethiopia.
PubMed: Chemical and antibacterial studies of two Helichrysum species of Greek origin.
PubMed: Sesquiterpenes in the frontal gland secretions of nasute soldier termites from New Guinea.
PubMed: Recent advances in pharmacologic study of natural anticancer agents in China.
PubMed: Components of moribund American elm trees as attractants to elm bark beetles,Hylurgopinus rufipes andScolytus multistriatus.
PubMed: Constituents of osmeterial secretion of pre-final instar larvae of citrus swallowtail,Papilio demodocus (Esper) (Lepidoptera: Papilionidae).
PubMed: Further studies of the terpenoid content in the gorgonian Eunicea succinea: 12,13-bisepieupalmerin, a new cembranolide.
PubMed: [Antitumor effect and pharmacological actions of beta-elemene isolated from the rhizome of Curcuma aromatica].
PubMed: Larval osmeterial secretions of the swallowtails (Papilio).
PubMed: Chemical composition of the frontal gland secretion ofSyntermes soldiers (Isoptera, Termitidae).
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