EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

isobutyl methyl ketone
4-methyl-2-pentanone

Sponsors

Name:4-methylpentan-2-one
CAS Number: 108-10-1Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:203-550-1
FDA UNII:U5T7B88CNP
Nikkaji Web:J2.861D
Beilstein Number:0605399
MDL:MFCD00008938
CoE Number:151
XlogP3:1.30 (est)
Molecular Weight:100.16084000
Formula:C6 H12 O
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:cosmetic, flavor and fragrance agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
JECFA Food Flavoring:301 4-methyl-2-pentanone
FLAVIS Number:07.017 (Old)
DG SANTE Food Flavourings:07.017 4-methylpentan-2-one
FEMA Number:2731 4-methyl-2-pentanone
FDA:No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm: METHYL ISOBUTYL KETONE
FDA Regulation:
FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION
Subpart F--Flavoring Agents and Related Substances
Sec. 172.515 Synthetic flavoring substances and adjuvants.


FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION
Subpart I--Multipurpose Additives
Sec. 172.842 Sorbitan monostearate.


FDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS
Subpart B--Substances for Use Only as Components of Adhesives
Sec. 175.105 Adhesives.


FDA PART 176 -- INDIRECT FOOD ADDITIVES: PAPER AND PAPERBOARD COMPONENTS
Subpart B--Substances for Use Only as Components of Paper and Paperboard
Sec. 176.180 Components of paper and paperboard in contact with dry food.


FDA PART 176 -- INDIRECT FOOD ADDITIVES: PAPER AND PAPERBOARD COMPONENTS
Subpart B--Substances for Use Only as Components of Paper and Paperboard
Sec. 176.200 Defoaming agents used in coatings.


FDA PART 176 -- INDIRECT FOOD ADDITIVES: PAPER AND PAPERBOARD COMPONENTS
Subpart B--Substances for Use Only as Components of Paper and Paperboard
Sec. 176.210 Defoaming agents used in the manufacture of paper and paperboard.


FDA PART 177 -- INDIRECT FOOD ADDITIVES: POLYMERS
Subpart B--Substances for Use as Basic Components of Single and Repeated Use Food Contact
Sec. 177.1650 Polysulfide polymer-polyepoxy resins.
 
Physical Properties:
Appearance:colorless clear liquid (est)
Assay: 99.00 to 100.00
Food Chemicals Codex Listed: Yes
Specific Gravity:0.79600 to 0.79900 @ 25.00 °C.
Pounds per Gallon - (est).: 6.624 to 6.648
Refractive Index:1.39100 to 1.39600 @ 20.00 °C.
Melting Point: -84.00 °C. @ 760.00 mm Hg
Boiling Point: 116.50 °C. @ 760.00 mm Hg
Acid Value: 2.00 max. KOH/g
Vapor Pressure:19.900000 mm/Hg @ 25.00 °C.
Vapor Density:3.5 ( Air = 1 )
Flash Point: 56.00 °F. TCC ( 13.33 °C. )
logP (o/w): 1.310
Soluble in:
 alcohol
 dipropylene glycol
 water, 1.90E+04 mg/L @ 25 °C (exp)
 
Organoleptic Properties:
Odor Type: green
Odor Strength:medium ,
recommend smelling in a 10.00 % solution or less
sharp solvent green herbal fruity dairy spicy
Odor Description:at 10.00 % in dipropylene glycol. sharp solvent green herbal fruity dairy spice
sharp solvent green herbal fruity dairy
Odor Description:Sharp solvent-like with green, herbal, fruity and dairy nuances
Mosciano, Gerard P&F 21, No. 1, 33, (1996)
Flavor Type: green
green vegetable herbal fruity dairy
Taste Description: Green, vegetative, herbal, fruity and dairy nuances
Mosciano, Gerard P&F 21, No. 1, 33, (1996)
Odor and/or flavor descriptions from others (if found).
Bedoukian Research
METHYL ISOBUTYL KETONE ≥99.0%, FCC, Kosher, Special Order
Odor Description:A sharp, green, herbal, fruity, spicy aroma
Used for its ethereal quality in fragrances.
Taste Description:green
Used in spice, apple, whiskey, fruit and ripe banana flavors.
Alfrebro
4-METHYL-2-PENTANONE NATURAL
Odor Description:Fruity, Ethereal, Spicy
Pell Wall Perfumes
Isobutyl Methyl Ketone
Odor Description:Sharp, solvent-like, ethereal, fruity, green. Diffusive
Used to give an ethereal quality to fragrances, add ‘lift’ and is particularly useful where a fruity element is desired, where it can enhance the top note, giving a more juicy effect. Usage level is normally well below 1% of the fragrance concentrate.
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: denaturants
perfuming agents
solvents
 
Suppliers:
Alfrebro
4-METHYL-2-PENTANONE NATURAL
Odor: Fruity, Ethereal, Spicy
Arkema
Methylisobutylketone
Odor: characteristic
Use: MIBK (Methylisobutylketone) is a stable, medium evaporating liquid and compatible with many organic materials, which makes it a good industrial solvent. MIBK can also be used in order to extract, separate and purify various products. It is used in the pharmaceutical, agrochemical industries, in fine chemistry…
Bedoukian Research
METHYL ISOBUTYL KETONE
≥99.0%, FCC, Kosher, Special Order
Odor: A sharp, green, herbal, fruity, spicy aroma
Use: Used for its ethereal quality in fragrances.
Flavor: green
Used in spice, apple, whiskey, fruit and ripe banana flavors.
Eastman Chemical
Eastman™ Methyl Isobutyl Ketone
Odor: characteristic
Use: Eastman™ Methyl Isobutyl Ketone (MIBK) is a medium-evaporating solvent. It is an active solvent for many synthetic resins including cellulosics, vinyl copolymers, acrylics, alkyds, polyesters, and epoxies. It is very useful in developing high-solids coatings because of its combination of high solvent activity and low density. In addition to its use as a solvent for inks, coatings, and adhesives, MIBK is used as an extraction agent in the dewaxing and deoiling of petroleum products. It is also used in the manufacture of germicides, fungicides, pharmaceuticals, electroplating solutions, and as a denaturant in many ethanol formulations.
EMD Millipore
For experimental / research use only.
isoButyl Methyl Ketone
Inoue Perfumery
isoBUTYL METHYL KETONE
Moellhausen
METHYL ISOBUTYL KETONE
Odor: fresh, fruity, somewhat burnt; banana-like with dairy nuance
Pell Wall Perfumes
Isobutyl Methyl Ketone
Odor: Sharp, solvent-like, ethereal, fruity, green. Diffusive
Use: Used to give an ethereal quality to fragrances, add ‘lift’ and is particularly useful where a fruity element is desired, where it can enhance the top note, giving a more juicy effect. Usage level is normally well below 1% of the fragrance concentrate.
Penta International
METHYL ISOBUTYL KETONE, Kosher
Penta International
METHYL ISOBUTYL KETONE, NATURAL, Kosher
Sigma-Aldrich
4-Methyl-2-pentanone, ≥99%, FCC
Odor: spicy; ethereal; fruity
Certified Food Grade Products
Silver Fern Chemical
Methyl Isobutyl Ketone (MIBK)
Odor: characteristic
Use: Methyl isobutyl ketone is primarily used as a solvent for paints, varnishes, nitrocellulose, lacquers, organic synthesis, and a denaturant for alcohol.
TCI AMERICA
For experimental / research use only.
4-Methyl-2-pentanone >99.5%(GC)
 
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
Xn - Harmful.
R 11 - Highly flammable.
R 20 - Harmful by inhalation.
R 36/37 - Irritating to eyes and respiratory system.
R 66 - Repeated exposure may cause skin dryness or cracking.
S 02 - Keep out of the reach of children.
S 09 - Keep container in a well-ventilated place.
S 16 - Keep away from sources of ignition - No Smoking.
S 29 - Do not empty into drains.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 2080 mg/kg
(Smyth et al., 1951)

oral-mouse LD50 [sex: M] 2670 mg/kg
(Tanii et al., 1986)

oral-mouse LD50 1200 mg/kg
(McOmie & Anderson, 1949a)

intraperitoneal-guinea pig LD50 800 mg/kg
"Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 4748, 1982.

oral-guinea pig LD50 1600 mg/kg
"Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 4748, 1982.

unreported-mammal (species unspecified) LD50 1396 mg/kg
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 51(5), Pg. 61, 1986.

intraperitoneal-mouse LD50 268 mg/kg
Shell Chemical Company. Unpublished Report. Vol. -, Pg. 7, 1961.

oral-mouse LD50 1900 mg/kg
National Technical Information Service. Vol. OTS0535383

intraperitoneal-rat LD50 400 mg/kg
"Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 4748, 1982.

oral-rat LD50 2080 mg/kg
Union Carbide Data Sheet. Vol. 4/25/1958

Dermal Toxicity:
skin-rabbit LD50 > 3000 mg/kg
National Technical Information Service. Vol. OTS0535383

Inhalation Toxicity:
inhalation-rat LC50 100000 mg/m3
National Technical Information Service. Vol. OTS0535383

inhalation-mouse LC50 23300 mg/m3
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 17(11), Pg. 52, 1973.

inhalation-guinea pig LCLo 68900 mg/m3/3H
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES CARDIAC: PULSE RATE SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
National Technical Information Service. Vol. OTS0535383

inhalation-man TCLo 2290 mg/m3
SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION
National Technical Information Service. Vol. OTS0535383

 
Safety in Use Information:
Category: cosmetic, flavor and fragrance agents
Recommendation for isobutyl methyl ketone usage levels up to:
  0.5000 % in the fragrance concentrate.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 6.10 (μg/capita/day)
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
 average usual ppmaverage maximum ppm
baked goods: -6.30000
beverages(nonalcoholic): -6.30000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: -6.30000
fruit ices: -6.30000
gelatins / puddings: --
granulated sugar: --
gravies: --
hard candy: -6.30000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --
 
Safety References:
European Food Safety Athority(efsa):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Flavouring Group Evaluation 7 (FGE.07): Saturated and unsaturated aliphatic secondary alcohols, ketones and esters of secondary alcohols and saturated linear or branched-chain carboxylic acids from chemical group 5
View page or View pdf

Flavouring Group Evaluation 63 (FGE.63): Consideration of aliphatic secondary alcohols, ketones and related esters evaluated by JECFA (59th meeting) structurally related to saturated and unsaturated aliphatic secondary alcohols, ketones and esters of secondary alcohols and saturated linear or branched-chain carboxylic acids evaluated by EFSA in FGE.07 (2005) (Commission Regulation (EC) No 1565/2000 of 18 July 2000)
View page or View pdf

Flavouring Group Evaluation 7, Revision 1 (FGE.07Rev1): Saturated and unsaturated aliphatic secondary alcohols, ketones and esters of secondary alcohols and saturated linear or branched-chain carboxylic acids from chemical group 5 (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Scientific opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) on a request from the Commission
View page or View pdf

Flavouring Group Evaluation 7, Revision 2 (FGE.07Rev2) : Saturated and unsaturated aliphatic secondary alcohols, ketones and esters of secondary alcohols and saturated linear or branched-chain carboxylic acids from chemical group 5
View page or View pdf

EPI System: View
EPA-Iris:IRIS
NIOSH International Chemical Safety Cards:search
NIOSH Pocket Guide:search
NLM Hazardous Substances Data Bank:Search
Chemical Carcinogenesis Research Information System:Search
Cancer Citations:Search
Toxicology Citations:Search
Env. Mutagen Info. Center:Search
NLM Developmental and Reproductive Toxicity:Search
EPA Substance Registry Services (TSCA):108-10-1
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :7909
National Institute of Allergy and Infectious Diseases:Data
WISER:UN 1245
WGK Germany:1
4-methylpentan-2-one
Chemidplus:0000108101
EPA/NOAA CAMEO:hazardous materials
RTECS:108-10-1
 
References:
 4-methylpentan-2-one
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:108-10-1
Pubchem (cid):7909
Pubchem (sid):134972890
Pherobase:View
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS):View
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C19263
HMDB (The Human Metabolome Database):HMDB02939
FooDB:FDB008174
Export Tariff Code:2914.19.0000
FDA Listing of Food Additive Status:View
Haz-Map:View
Household Products:Search
Typical G.C.
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
RSC Learn Chemistry:View
 
Potential Blenders and core components note
For Odor
acidic
2-
ethyl butyric acid
FL/FR
aldehydic
agrumen nitrile
FR
alliaceous
dibutyl sulfide
FL/FR
dipropyl disulfide
FL/FR
animal
iso
butyl quinoline
FR
anisic
amyl furoate
FL/FR
estragole
FL/FR
ocimum basilicum leaf oil america
FL/FR
balsamic
siam
benzoin absolute
FL/FR
cinnamyl formate
FL/FR
christmas
pine fragrance
FR
bready
coffee furanone
FL/FR
caramellic
2-iso
butyl-3-methyl pyrazine
FL/FR
chocolate
2,4,5-
trimethyl thiazole
FL/FR
citrus
(Z)-4-
decenal
FL/FR
iso
decyl acetate
FR
methyl heptenone
FL/FR
ocimene quintoxide
FL/FR
coconut
alpha-
angelica lactone
FL/FR
coumarinic
phthalide
FL/FR
earthy
geosmin
FL/FR
(S)-1-
octen-3-ol
FL/FR
ethereal
butyl acetate
FL/FR
ethyl 4-pentenoate
FL/FR
2-
methyl valeraldehyde
FL/FR
iso
propyl formate
FL/FR
fatty
2,4-
decadien-1-ol
FL/FR
(E,E)-2,4-
decadien-1-ol
FL/FR
2-
octenal
FL/FR
(E)-2-
octenal
FL/FR
floral
iso
amyl angelate
FL/FR
alpha-
amyl cinnamaldehyde
FL/FR
cassis cyclohexene
FR
cassis oxime 10%
FR
cilantro herb oil egypt
FL/FR
cymbopogon validus leaf oil
FR
dictamnus hispanicus oil
FR
dihydrocitronellyl ethyl ether
FR
dihydrorose oxide
FR
dimethyl benzyl carbinyl butyrate
FL/FR
2,4-
dimethyl-3-cyclohexene-1-methanol
FR
geranium oil africa
FL/FR
geranium oil egypt
FL/FR
jasmin absolute egypt (from concrete)
FL/FR
linden flower absolute
FR
melaleuca ericifolia leaf oil
FR
menthadienyl formate
FR
para-
methyl benzyl acetate
FL/FR
methyl benzyl acetate (mixed ortho-,meta-,para-)
FL/FR
neryl formate
FL/FR
nonan-3-yl acetate
FL/FR
3-
nonanone
FL/FR
2-
pentyl cyclopentanone
FR
iso
phytol
FL/FR
prenyl salicylate
FL/FR
(Z)-
rose oxide
FL/FR
rose pyran
FR
5-
tricyclodecenyl acetate
FR
fruity
iso
amyl acetate
FL/FR
para-
anisyl propionate
FL/FR
balsam specialty
FR
3-
butyl bicyclo[3.2.1]-6-octen-2-one
FR
ethyl 2-ethyl acetoacetate
FL/FR
2-
methyl butyl isovalerate
FL/FR
2-
nonanone
FL/FR
propyl acetate
FL/FR
tropical indene
FR
green
acetaldehyde butyl phenethyl acetal
FL/FR
agrumen aldehyde
FR
birch leaf specialty
FR
iso
butyl heptanoate
FL/FR
butyl heptanoate
FL/FR
2-iso
butyl thiazole
FL/FR
2-sec-
butyl thiazole
FL/FR
S-sec-
butyl thioisovalerate
FL/FR
carrot leaf oil (daucus carota ssp.maximus)
FR
chrysanthemum carbaldehyde
FR
cortex pyridine
FL/FR
dicyclopentadiene propionate
FR
galbanum decatriene
FL/FR
heptanal (aldehyde C-7)
FL/FR
1-
heptanol
FL/FR
heptyl benzoate
FL/FR
herbal cyclohexane
FR
(Z)-4-
hexen-1-ol
FL/FR
(Z)-2-
hexen-1-ol
FL/FR
(Z)-3-
hexen-1-yl tiglate
FL/FR
3-
hexenyl 2-methyl butyrate
FL/FR
hexyl hexanoate
FL/FR
hexyl tiglate
FL/FR
english
ivy leaf absolute
FR
(Z)-
leaf acetal
FL/FR
magnolia flower oil CO2 extract
FL/FR
marigold pot absolute
FL/FR
methyl heptine carbonate
FL/FR
6-
methyl-3-hepten-2-one
FL/FR
nerol oxide
FL/FR
(Z,Z)-3,6-
nonadien-1-ol
FL/FR
1-
penten-3-ol
FL/FR
3-
propyl bicyclo(3.2.1)-6-octen-2-one
FR
seaweed absolute (fucus vesiculosus et serratus)
FL/FR
terpinyl propionate
FL/FR
triplal / ethyl anthranilate schiff's base
FR
herbal
6-
acetoxydihydrotheaspirane
FL/FR
alpha-
amyl cinnamyl formate
FL/FR
iso
amyl heptanoate
FL/FR
anethum graveolens herb oil
FL/FR
anethum graveolens herb tincture
FL/FR
anthemis nobilis flower extract
FL/FR
anthemis nobilis flower oil roman
FL/FR
apium graveolens seed oil
FL/FR
apium graveolens seed oil india
FL/FR
artemisia alba oil
FR
artemisia ludoviciana oil
FR
sweet
basil absolute
FL/FR
buchu mercaptan acetate
FL/FR
butyl levulinate
FL/FR
3-
butylidene phthalide
FL/FR
(+)-alpha-
campholenic aldehyde
FL/FR
chamomile propionate
FR
chamomile valerate
FR
chrysanthemum ketone
FR
coriander oleoresin
FL/FR
dill weed oil cuba
FL/FR
dill weed oil reunion
FL/FR
dimethyl benzyl carbinyl crotonate
FL/FR
dimethyl benzyl carbinyl formate
FL/FR
2-(2,4-
dimethyl-3-cyclohexene-1-yl)-4,4-dimethyl-1,3-oxathiane
FR
cis-
herbal cyclohexane
FR
herbal dioxane
FR
herbal heptane
FR
hop absolute
FL/FR
hop oil
FL/FR
lantana camara flower oil
FR
linalyl formate
FL/FR
linalyl octanoate
FL/FR
marigold oil mexico
FL/FR
melaleuca leucadendron var. cajuputi leaf oil
FL/FR
1-para-
menthen-9-yl acetate
FL/FR
1-(2-
methyl allyl oxy) heptane
FR
methyl hexyl ether
FL/FR
(E)-6-
methyl-3-hepten-2-one
FL/FR
monarda fistulosa oil
FR
myrtle oil
FL/FR
nonisyl formate
FR
3-
octanon-1-ol
FL/FR
1-
octen-3-yl acetate
FL/FR
oregano specialty
FR
origanum oil
FL/FR
origanum oil greece
FL/FR
curled
parsley seed oil
FL/FR
perilla leaf oil
FL/FR
perillaldehyde
FL/FR
petroselinum crispum seed oil CO2 extract
FL/FR
phenyl acetaldehyde diisoamyl acetal
FR
prenyl senecioate
FL/FR
3-
propylidene phthalide
FL/FR
reseda absolute
FR
rosmarinus officinalis extract
FL/FR
rosmarinus officinalis tincture
FL/FR
rue oil
FL/FR
rue oil cuba
FL/FR
tagete oil CO2 extract
FL/FR
tagete oil egypt
FL/FR
tagete oil rwanda
FL/FR
tagete oil south africa
FL/FR
tagete oil turkey
FL/FR
tagete oil zambia
FL/FR
theaspirane
FL/FR
thyme absolute
FL/FR
tricyclodecenyl isobutyrate
FR
tricyclodecenyl propionate
FR
tricyclodecyl acetate
FR
viridiflorol
FL/FR
wormwood oil america
FL/FR
wormwood oil italy
FL/FR
wormwood oil poland
FL/FR
minty
carvyl acetate
FL/FR
(-)-
menthone
FL/FR
(-)-iso
pulegol
FL/FR
mossy
treemoss absolute
FR
musty
cocoa butenal
FL/FR
orris
orris capronate
FL/FR
soapy
methyl anthranilate / hexyl cinnamaldehyde schiff's base
FR
spicy
boldus leaf oil
CS
iso
butyl angelate
FL/FR
trans-
carveol
FL/FR
(-)-
cubenol
FL/FR
cuminaldehyde
FL/FR
iso
cyclogeraniol (IFF)
FR
origanum majorana oil
FL/FR
outdoors specialty
FR
spicy carbonate
FR
sulfurous
3-(
methyl thio) hexanol
FL/FR
tonka
(±)-
dihydromint lactone
FL/FR
waxy
ethyl laurate
FL/FR
2-
nonanol
FL/FR
woody
cinnamyl tiglate
FL/FR
dalbergia sissoo leaf oil
FR
2-
decalinyl acetate
FR
alpha-
farnesene
FL/FR
alpha-
farnesene isomer
FL/FR
patchouli absolute
FR
verdoxan
FR
yeasty
2-
octen-4-one
FL/FR
For Flavor
No flavor group found for these
6-
acetoxydihydrotheaspirane
FL/FR
4-
acetyl-2-isopropenyl pyridine
FL
iso
amyl angelate
FL/FR
alpha-
amyl cinnamyl formate
FL/FR
amyl furoate
FL/FR
para-
anisyl propionate
FL/FR
benzyl methyl tiglate
FL
iso
butyl heptanoate
FL/FR
4-
butyl thiazole
FL
2-sec-
butyl thiazole
FL/FR
S-sec-
butyl thioisovalerate
FL/FR
trans-
carveol
FL/FR
cinnamyl tiglate
FL/FR
(E,E)-2,4-
decadien-1-ol
FL/FR
(±)-(cis+trans)-1,2-
dihydroperillaldehyde
FL
dimethyl benzyl carbinyl crotonate
FL/FR
dimethyl benzyl carbinyl formate
FL/FR
ethyl 4-pentenoate
FL/FR
fig leaf absolute
FL
heptanal 2,3-butane diol acetal
FL
heptyl benzoate
FL/FR
(E,E)-2,4-
hexadien-1-ol
FL
linalyl formate
FL/FR
magnolia flower oil CO2 extract
FL/FR
melaleuca leucadendron var. cajuputi leaf oil
FL/FR
methyl benzyl acetate (mixed ortho-,meta-,para-)
FL/FR
(E)-6-
methyl-3-hepten-2-one
FL/FR
6-
methyl-3-hepten-2-one
FL/FR
nonan-3-yl acetate
FL/FR
3-
octanon-1-ol
FL/FR
(S)-1-
octen-3-ol
FL/FR
2-
octenal
FL/FR
3-
octyl butyrate
FL
perilla leaf oil
FL/FR
prenyl senecioate
FL/FR
2-
propyl thiazole
FL
seaweed absolute (fucus vesiculosus et serratus)
FL/FR
ortho-
vinyl anisole
FL
viridiflorol
FL/FR
althaea officinalis root tincture
FL
acidic
acidic
2-
ethyl butyric acid
FL/FR
propionic acid
FL
alliaceous
allyl thiopropionate
FL
dipropyl disulfide
FL/FR
celery
3-
butylidene phthalide
FL/FR
cheesy
2-
nonanone
FL/FR
citrus
(Z)-4-
decenal
FL/FR
cooling
theaspirane
FL/FR
coumarinic
phthalide
FL/FR
creamy
althaea officinalis root extract
FL
alpha-
angelica lactone
FL/FR
earthy
geosmin
FL/FR
estery
propyl acetate
FL/FR
ethereal
butyl acetate
FL/FR
methyl hexyl ether
FL/FR
fatty
2,4-
decadien-1-ol
FL/FR
(E)-2-
octenal
FL/FR
floral
dimethyl benzyl carbinyl butyrate
FL/FR
geranium oil africa
FL/FR
geranium oil egypt
FL/FR
jasmin absolute egypt (from concrete)
FL/FR
fruity
iso
amyl acetate
FL/FR
buchu mercaptan acetate
FL/FR
butyl heptanoate
FL/FR
ethyl 2-ethyl acetoacetate
FL/FR
2,4-
hexadien-1-ol
FL
hexyl hexanoate
FL/FR
linalyl octanoate
FL/FR
1-para-
menthen-9-yl acetate
FL/FR
para-
methyl benzyl acetate
FL/FR
2-
methyl butyl isovalerate
FL/FR
neryl formate
FL/FR
iso
propyl formate
FL/FR
tagete oil CO2 extract
FL/FR
tagete oil rwanda
FL/FR
tagete oil south africa
FL/FR
tagete oil turkey
FL/FR
tagete oil zambia
FL/FR
green
acetaldehyde butyl phenethyl acetal
FL/FR
anethum graveolens herb tincture
FL/FR
iso
butyl angelate
FL/FR
2-iso
butyl thiazole
FL/FR
2-iso
butyl-3-methyl pyrazine
FL/FR
(+)-alpha-
campholenic aldehyde
FL/FR
celery distillates
FL
cocoa butenal
FL/FR
coriander oleoresin
FL/FR
cortex pyridine
FL/FR
dibutyl sulfide
FL/FR
dihydroxyacetophenone (mixed isomers)
FL
alpha-
farnesene
FL/FR
alpha-
farnesene isomer
FL/FR
galbanum decatriene
FL/FR
heptanal (aldehyde C-7)
FL/FR
(Z)-4-
hexen-1-ol
FL/FR
(Z)-2-
hexen-1-ol
FL/FR
(Z)-3-
hexen-1-yl tiglate
FL/FR
3-
hexenyl 2-methyl butyrate
FL/FR
2-
hexyl pyridine
FL
hexyl tiglate
FL/FR
horseradish oil
FL
(Z)-
leaf acetal
FL/FR
marigold pot absolute
FL/FR
methyl heptenone
FL/FR
methyl heptine carbonate
FL/FR
4-
methyl thiazole
FL
nerol oxide
FL/FR
3-
nonanone
FL/FR
ocimene quintoxide
FL/FR
1-
octen-3-yl acetate
FL/FR
4-
penten-1-yl acetate
FL
1-
penten-3-ol
FL/FR
3-
propylidene phthalide
FL/FR
(Z)-
rose oxide
FL/FR
terpinyl propionate
FL/FR
herbal
iso
amyl heptanoate
FL/FR
anethum graveolens herb oil
FL/FR
anthemis nobilis flower extract
FL/FR
anthemis nobilis flower oil roman
FL/FR
apium graveolens seed oil
FL/FR
apium graveolens seed oil india
FL/FR
sweet
basil absolute
FL/FR
butyl levulinate
FL/FR
celery seed oleoresin
FL
cilantro herb oil egypt
FL/FR
dill weed oil cuba
FL/FR
dill weed oil reunion
FL/FR
hop absolute
FL/FR
hop oil
FL/FR
ilex paraguariensis leaf extract
FL
marigold oil mexico
FL/FR
ocimum basilicum leaf oil america
FL/FR
origanum majorana oil
FL/FR
origanum oil
FL/FR
origanum oil greece
FL/FR
curled
parsley seed oil
FL/FR
petroselinum crispum seed oil CO2 extract
FL/FR
prenyl salicylate
FL/FR
rosmarinus officinalis extract
FL/FR
rosmarinus officinalis tincture
FL/FR
rue oil
FL/FR
rue oil cuba
FL/FR
tagete oil egypt
FL/FR
thyme absolute
FL/FR
wormwood oil america
FL/FR
wormwood oil italy
FL/FR
wormwood oil poland
FL/FR
lactonic
(±)-
dihydromint lactone
FL/FR
licorice
estragole
FL/FR
metallic
3-(
methyl thio) hexanol
FL/FR
minty
carvyl acetate
FL/FR
(-)-
menthone
FL/FR
(-)-iso
pulegol
FL/FR
nutty
coffee furanone
FL/FR
2,4,5-
trimethyl thiazole
FL/FR
oily
iso
phytol
FL/FR
orris
orris capronate
FL/FR
seafood
1,4-
dithiane
FL
solvent
1-
heptanol
FL/FR
methyl phenyl sulfide
FL
spicy
siam
benzoin absolute
FL/FR
cinnamyl formate
FL/FR
(-)-
cubenol
FL/FR
cuminaldehyde
FL/FR
myrtle oil
FL/FR
perillaldehyde
FL/FR
tropical
alpha-
amyl cinnamaldehyde
FL/FR
vegetable
2-
methyl valeraldehyde
FL/FR
2-
octen-4-one
FL/FR
waxy
ethyl laurate
FL/FR
(Z,Z)-3,6-
nonadien-1-ol
FL/FR
2-
nonanol
FL/FR
 
Potential Uses:
FRapple
FRbanana
FRcherry
FRcream
FLdairy
FRfruit
FRgrape
FRgreen
FRherbal
FRmint
FRorange
FRpear
FRpineapple
FRspice
FLwhiskey
 
Occurrence (nature, food, other):note
 beer
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 coffee
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 elder black elder flower oil
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 ginger oil
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 grape
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 lavender oil spike spain @ 0.003%
Data GC Search Trop Picture
 orange fruit
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 tagete oil rwanda @ 0.03%
Data GC Search Trop Picture
 vinegar
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Synonyms:
isobutylmethyl ketone
isohexanone
 hexone
 ketone, isobutyl methyl
 methyl 2-methylpropyl ketone
4-methyl 2-pentanone
 methyl iso-butyl ketone
 methyl isobutyl ketone
 methyl isobutyl ketone natural
4-methyl pentan-2-one
2-methyl propyl methyl ketone
4-methyl-2-oxopentane
4-methyl-2-pentanone
2-methyl-4-oxopentane
2-methyl-4-pentanone
 methyl-isobutylketone
4-methyl-pentan-2-one
 methylisobutylketone
4-methylpentan-2-one
2-methylpropyl methyl ketone
 mibk
2-pentanone, 4-methyl-
isopropyl acetone
 

Articles:

PubMed:The Japan Flavour and Fragrance Materials Association's (JFFMA) safety assessment of acetal food flavouring substances uniquely used in Japan.
PubMed:Influence of manufacturing conditions and crop season on the formation of 4-mercapto-4-methyl-2-pentanone in Japanese green tea (sen-cha).
PubMed:Changes in analytical and volatile compositions of red wines induced by pre-fermentation heat treatment of grapes.
PubMed:Quantification of Polyfunctional Thiols in Wine by HS-SPME-GC-MS Following Extractive Alkylation.
PubMed:Volatile compounds responsible for aroma of Jutrzenka liquer wine.
PubMed:Hydrothermal conversion of bamboo: identification and distribution of the components in solid residue, water-soluble and acetone-soluble fractions.
PubMed:A powerful methodological approach combining headspace solid phase microextraction, mass spectrometry and multivariate analysis for profiling the volatile metabolomic pattern of beer starting raw materials.
PubMed:Influence of volatile thiols in the development of blackcurrant aroma in red wine.
PubMed:Inhalation two-generation reproductive toxicity study of methyl isobutyl ketone in rats.
PubMed:Developmental toxicity evaluation of inhaled methyl isobutyl ketone in Fischer 344 rats and CD-1 mice.
PubMed:Color, lipid oxidation, sensory quality, and aroma compounds of beef steaks displayed under different levels of oxygen in a modified atmosphere package.
PubMed:Sensory and chemical characterisation of the aroma of Prieto Picudo rosé wines: the differential role of autochthonous yeast strains on aroma profiles.
PubMed:Determination of cadmium, copper, and lead in sodium chloride food salts by flame atomic absorption spectroscopy.
PubMed:Determination of semduramicin in poultry feed additive, premixture and compound feed by liquid chromatography and UV spectrophotometric detection after post-column derivatisation.
PubMed:Identification of potent odorants in Japanese green tea (Sen-cha).
PubMed:Screening method for determination of high levels of cadmium, lead, and copper in foods by polarized Zeeman atomic absorption spectrometry using discrete nebulization technique.
PubMed:New factor characterizing the in-mouth release of odorants (volatile thiols): compositional changes in odorants exhaled from the human nose during drinking.
PubMed:Cobalt content of foods and diets in a Spanish population (short communication).
PubMed:Atomic absorption spectrophotometric method for determination of polydimethylsiloxane residues in pineapple juice: collaborative study.
PubMed:Aroma composition changes in early season grapefruit juice produced from thermal concentration.
PubMed:Occurrence of polyfunctional thiols in fresh lager beers.
PubMed:Combinatorial synthesis and sensorial properties of mercapto primary alcohols and analogues.
PubMed:Identification of potent odorants in different green tea varieties using flavor dilution technique.
PubMed:Determination of tin, vanadium, iron, and molybdenum in various matrices by atomic absorption spectrometry using a simultaneous liquid-liquid extraction procedure.
PubMed:Determination of tin in canned fruits and vegetables by atomic absorption spectrometry and liquid-liquid extraction.
PubMed:Atomic absorption spectrophotometric determination of chromium in foods.
PubMed:[Evaluation of heavy metal contamination of potatoes from various regions of Poland].
PubMed:Electrothermal atomic absorption spectrometric determination of selenium in foods and diets.
PubMed:Identification and characterization of bacteria isolated under selective pressure of volatile organic compounds.
PubMed:Quantitative evaluation of sensory irritating and neurobehavioural properties of aliphatic ketones in mice.
PubMed:Multiple microbial activities for volatile organic compounds reduction by biofiltration.
 
Notes:
Present in orange, lemon, concord grape, vinegar, cheeses, cooked beef, roasted peanut and other foodstuffs. Flavouring ingredient Methyl isobutyl ketone (MIBK) is an organic solvent. MIBK is among the top ten most popular organic solvents used in industry. MIBK is occasionally found as a volatile component of urine. MIBK in urine is considered as a biological marker of occupational exposure to this solvent. Olfactory perception is significant but adaptation may occur. The typical toxicity effects of MIBK in humans exposed at 50 to 100 ppm are mucous membrane irritation and weak effects on the central nervous system (CNS) such as headache. Visual dysfunction has been reported in workers exposed to a mixture of organic solvents containing MIBK. Memory impairment was detected in clinical observation on a 44-year-old man who had been exposed to MIBK at 100 ppm for more than 10 years. Regarding to the route of absorption, skin penetration of MIBK is substantial. (PMID: 12592578, 17485256, 16464817, 5556886)
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