methyl hexyl ketone
Trace constit. of plant oils. Also present in apple, apricot, banana, papaya, wheat bread, other breads, cheddar cheese, Swiss cheese, coffee, black tea, roasted filbert, plum brandy and cooked shrimp. Flavouring ingredient
  • A.C.S. International
  • Advanced Biotech
  • Alfrebro
    • Alfrebro LLC
      Let's get reacquainted
      Building great taste with aroma chemicals, extracts, and distillates
      The Alfrebro brand was established in the early 1900s by Alex Fries & Brothers, a Cincinnati Flavor Company. In 1980, the brand was re-launched as an aroma chemical manufacturer. Since its inception, Alfrebro’s primary focus has been to provide quality natural and high value synthetic chemicals.
      Email: Sarah Forbis
      Email: Sales
      Voice: 513-539-3021
      Fax: 513-539-7372
      US Voice: 513-539-7373
  • Apiscent Labs
    • Apiscent Labs, LLC
      Delivery of Quality
      Custom manufacturer and international supplier of fine ingredients.
      We believe inspired chemistry enriches lives. That's why our team is guided by a mission to provide fine ingredients to the worldwide pharmaceutical, flavor and fragrance markets with a primary focus on the manufacturing of value-added, research-based molecules. We're innovative problem solvers committed to excellence at every phase. Our work builds the foundation for our clients' continued success.
      Email: Info
      Email: Carl Sheeley
      Email: Customer Service
      Voice: +1 (414) 744 3993
      Fax: +1 (414) 744 7111
      2 OCTANONE
  • Associate Allied Chemicals
    • Associate Allied Chemicals
      Quality, Service and Values
      Our aim is to become a reliable one-stop shop for our customers.
      Distributor and Agents of high quality raw materials for the fragrance, flavour and cosmetic industry. Partnering and sourcing raw materials directly from some of the best recognised names to provide consistent quality to our esteemed customers.
      Email: Info
      Email: Sachin Gandhi
      Voice: +91 22 2419 8800
      Fax: +91 22 2413 5786
      Methyl Hexyl Ketone
  • Augustus Oils
    • Augustus Oils Ltd
      The Premier Supplier
      Augustus Oils Ltd, in harmony with nature - to present it at its best...
      A wealth of experience, expertise and knowledge has allowed Augustus to bridge the gulf in expectation and trust between growers and users of natural ingredients. The Company works in partnership with customers on the one hand, and growers, farmers and distillers on the other. Both users and producers can then focus on exactly what they do best, while skilled Augustus technicians closely monitor and control the delivered product. This ensures users can have the confidence that they will receive the best raw materials suited to their requirements. Augustus has invested in modern, well equipped laboratories to provide unparalleled control of quality, and a development environment that continues to produce innovative ranges of natural ingredients. The strength of the company is built on both its comprehensive knowledge base, and extensive stocks of raw materials for both fragrance and flavour use. To complement its range of conventional and Organic Essential Oils and Aroma Chemicals, Augustus also offers a steadily increasing range of its own, UK manufactured Natural Extracts, Absolutes, Resinoids and Natural Chemicals. These again are fully tested and certificated, and very tightly quality controlled. Augustus is committed to promoting the use of natural ingredients, wherever the potential lies and to provide an environment of support and trust to both our customers and suppliers.
      Email: Enquiries
      Email: Sales
      Email: web site enquiries
      Voice: +44 (0)1420 590555
      Fax: +44 (0)1420 592420
      Methyl Hexyl Ketone
  • Axxence Aromatic
    • Axxence Aromatic GmbH
      We bring nature to your flavour
      Dedicated to provide the best possible quality and supply service of natural aroma ingredients.
      Axxence Aromatic is entirely dedicated to provide the best possible quality and supply service of natural aroma ingredients to the Flavour & Fragrance Industry worldwide.
      Email: Service
      Voice: +49.2822.68561.0
      Fax: +49.2822.68561.39
      Products List: View
      280200 METHYL HEXYL KETONE Natural Kosher
  • Bedoukian Research
    • Bedoukian Research, Inc.
      Constantly Improving
      Working closely with our customers to meet their requirements.
      Paul Bedoukian founded the company to fill a niche as a supplier of high quality specialty aroma and flavor ingredients. In 1975 the company began manufacturing insect pheromones which are chemically similar to flavor and fragrance ingredients. Today, Bedoukian Research offers more than 450 Aroma Chemicals and 50 Insect Pheromones, while also providing custom manufacturing services to the pharmaceutical, agrochemical, and specialty chemical industries.
      US Email: Customer Service
      US Voice: 1-203-830-4000
      US Fax: 1-203-830-4010
      Products List: View
      601 METHYL HEXYL KETONE ≥97.5%, FCC, Kosher
      An interesting note for lilac compositions.
      Adds ketonic notes for a variety of cheese flavors, unroasted nuts especially hazelnut and cashews.
  • Berjé
    • Berje Inc.
      The solution is clear
      Where the world comes to its senses - Berjé is a global distributor of Essential Oils and Aromatic Chemicals.
      Berjé is a family-owned business that has been in operation for six decades. The company's origins and strength lie in a profound understanding of the supply and the quality of the diverse raw materials consumed by the flavor and fragrance industries. This base was expanded upon more than two decades ago to include fragrance production. The company's unparalleled raw material expertise is focused on the supply of essential oils and aromatic chemicals. This is supported by our long-standing relationships with a worldwide fabric of producers ensuring the greatest prospects for uninterrupted supply in markets that are often volatile and unpredictable.
      Email: For Information
      Email: For Sales
      Voice: 973-748-8980
      Fax: 973-680-9618
      Flavor Ingredients
      Fragrance Ingredients
      Functional Ingredients
      Happening at Berje
      Methyl Hexyl Ketone
  • CTC Organics
    • CTC Organics
      For More Than 40 Year
      Your source for rare aroma chemicals for the flavor and fragrance industy.
      “The world is run by middle men.” The number of times I have heard Dr. Liu utter those words are innumerable. He loved reciting and recording famous quotes and had many of his own. Among his many talents, Dr. Liu had a unique genius in the area of chemistry. He had an uncanny understanding of the pulse of the chemical industry and was a superb salesman.
      US Email: Customer Service
      US Voice: (404) 524-6744
      US Fax: (404) 577-1651
      W1510 2-octanone
  • Excellentia International
    • Excellentia International
      Ingredients by Nature
      Exceptional quality and excellence in meeting our customers requirements.
      Excellentia International was founded in 2010 through the merger of Excellentia Flavors LLC and Polarome International. Collectively, these companies account for more than one hundred years of industry experience, and are recognized for exceptional quality and excellence in meeting our customers’ requirements.
      Email: Info
      Email: Sales
      Email: Regulatory
      Voice: 732.749.9840
      Our Services
      Methyl Hexyl Ketone (2-Octanone) Natural
  • Firmenich
    • Firmenich Inc.
      We Create
      We create perfumes and flavors for the World's most desirable brands.
      Firmenich is the largest privately-owned company in the perfume and flavor business. Swiss and family owned, we have created many of the world’s favorite perfumes for over 100 years and produced a number of the most well known flavors we enjoy each day.
      US Email: Fred Keifer
      US Voice: +1 609 452 1000
      US Fax: +1 609 452 6077
      958910 2-Octanone min. 98%, Kosher

      2-OCTANONE adds nice fruity, blue and parmesan cheese-like notes with mushroom and dairy nuances to dairy, fruit and cooked meat flavors.
  • Indukern F&F
  • Lluch Essence
    • Lluch Essence S.L.
      A family company dedicated to sales and distribution
      Flexibility, availability, price and quality.
      Flexibility, availability, price and quality make LLUCH ESSENCE S.L. one of Europe’s references when it comes to essential oils and aroma chemicals, and it is now well known all around the world.
      Email: Info
      Voice: 34 93 379 38 49
      Fax: 34 93 370 65 04
  • M&U International
    • M&U International LLC
      Steady supply & demand
      Meeting customers increasing demands at home as well as abroad.
      M&U dedicates itself to the development and production of new products as well as continuously promoting those new products. We’ve maintained a steady supply&demand relationship with a large number of manufacturers at home and abroad. We’ve developed an extensive network and because of our relationships with these manufacturers, we’re able to provide a stable supply of great quality materials. We’re located in China’s largest communications hub, Shanghai and in the U.S. near one of the largest sea ports on the East Coast. The strategic locations of our facilities ensure convenient, prompt and secure delivery of our products to our customers. We warmly welcome your inquiries, come witness our solemn commitment for yourself.
      Email: Sales
      US Email: Sales
      Voice: +86-21-32515501 60762991 60762992
      Fax: +86-21-32515502 64204960
      US Voice: 908-359-9000
      US Fax: 908-359-9002
      A0402 -METHYL HEXYL KETONE, Kosher
  • Moellhausen
    • Moellhausen S.P.A.
      Innovation and commitment in the name of excellence.
      After 50 years in business, Moellhausen stands out as one of the world’s leading family-run companies in the industry of flavors and fragrances, raw materials, and specialties. My personal history is inextricably bound to that of the company, and I continue to dedicate all my energy to it along with our partners and collaborators who have supported us thus far with dedication, passion, love, and experience. Continuous investments and a professionalism aimed at achieving the highest levels of performance in service and quality, along with that same dedication, passion, love, and experience, have together enabled us to reach the absolute avant-garde level that characterizes Moellhausen today, recognized worldwide for its modernity, innovation, creativity, and respect for the environment and the safety and rights of those who work with us. As President and CEO of the company for 32 years, I offer a well-deserved thank you to all of our numerous customers, suppliers, employees, and company friends for helping to sustain our unstoppable and honorable growth. And it is with the support of all of our stakeholders that we will confidently continue to pursue our commitment to further advancing the excellence that our industry demands.
      Voice: +39 039.685.6262
      Fax: +39 039.685.6263
      A network of knowledge to grow together
      Sustainability is at the foundation of a
      Pervasive technology and total control
      100833 2-OCTANONE
  • Odowell Co.,ltd
    • Odowell Co.,ltd
      Fulfilling Demand
      Product quality and consistency.
      Odowell is specialized in producing and distributing aroma chemicals for Flavors &Fragrances industry since 2012. Product ranges are ketones, esters,alcohols, aldehydes , ethers and lactones. We have the most comprehensive range of C3-C15 aliphatic ketones, aromatic ketones and high purity electronic chemicals, providing to many industries related to our daily life.
      Email: Info
      Email: Sales
      Voice: +86-21-56410859
      Fax: 4006981163 ext.28633
      Phone, Kunshan Odowell+86-512-55380008
      Fax, Kunshan Odowell+86-512-55380009
      10-51-004 Methyl hexyl ketone
  • Penta International
    • Penta International Corporation
      Chemistry innovation
      At Penta, our products and services help businesses do business better.
      For over 30 years, Penta Manufacturing Company has played a growing role in worldwide chemistry innovations and applications. As an industry leader, Penta continues to pioneer chemistry-based solutions for practically every area of commerce. Our products and expertise have helped fuel technical advances in dozens of commercial applications including flavoring, coloring, fragrances and chemical processes.
      US Email: Technical Services
      US Email: Sales
      US Voice: (973) 740-2300
      US Fax: (973) 740-1839
      13-51600 METHYL HEXYL KETONE 90, Kosher
      13-51602 METHYL HEXYL KETONE, NATURAL, Kosher
  • PerfumersWorld
    • PerfumersWorld Ltd.
      feeeel... the smell!
      The one-stop resource for the creative perfumer.
      No minimum orders. Aroma chemicals, essential oils, isolates, pheremones, absolutes, resinoids, FleuressenceTM key bases, PWx FactorTM, solubilizers, kits, creation systems, workshops, training, distance learning, The PerfumersWorld Perfumer's Studio, The Perfumer’s Formulation Bulletin, perfumery software, bespoke creation, analysis, consultancy, project counselling, trouble-shooting, unperfumed product bases, bottles, smelling strips, scales, distillation, equipment and inspiration!
      Email: Enquiries
      Email: Sales
      Voice: +66(0)2-99-800-80
      Fax: +66(0)2-99-800-80
      PerfumersWorld Skype Skype
      Software: Perfumer's Workbook
      3LF00299 Methyl hexyl ketone
      Blends-well-with - +2-heptanone Herbaceous-notes
  • Sigma-Aldrich
    • Sigma-Aldrich
      Complete Supply Chain
      The perfect blend of products and services that bring your creativity to life.
      Sigma-Aldrich is a leading Life Science and High Technology company dedicated to providing high-quality, safe and certified flavor ingredients with transparent and easily accessible documentation to customers around the globe. Sigma-Aldrich also provides a suite of analytical tools that allow food analysts to simplify sample preparation, cleanup and analysis steps, while increasing sensitivity to trace ingredients and harmful substances to meet regulations and quality standards.
      Email: Information
      US Email: Sales
      US Voice: 800-244-1173
      US Fax: 800-368-4661
      Certified Food Grade Products
      W280208 2-Octanone, ≥98%, FG
      W280220 2-Octanone, natural, 98%, FG
  • SRS Aromatics
    • SRS Aromatics Ltd
      For over 25 years
      Bringing flavour and fragrance into your world.
      As suppliers / distributors of ingredients to the fragrance and flavour industries, our goal is to provide high quality materials at competitive prices with an exceptional level of service. Established in 1984, SRS Aromatics Ltd is an independent family owned business which has become very well-respected within the fragrance and flavour industry as a reliable and trustworthy partner. Over the years this has allowed the company to develop strong relationships with many global manufacturers; several of whom we represent in the UK. A core aim of our business is to work extremely closely with both our suppliers and customers to maximise service levels with minimum disruption to supply.
      Email: Info
      Email: Sales
      Voice: +44 (0) 1284 704076
      Fax: +44 (0) 1284 760819
  • Taytonn
      Supplying Asia Pacific
      We fully understand the demands of the F&F industry and we endeavour to supply quality products, with ready availability and a personalised service.
      Since 2001 TAYTONN has been distributing key ingredients to the Fragrance and Flavor industry in Asia. We work closely with customers, principals and vendors. Together we forecast demand and match it with supply of aroma chemicals, essential oils and natural isolates & extracts. Sourced from around the world, our F&F ingredient inventory in Singapore is ready to ship to any location in Asia and beyond. Time and again, we help our principals introduce new discoveries to the F&F market - stimulating creativity and bringing value added proposition to our customers.
      Email: Info
      Email: Sales
      Voice: + 65 - 6861 8113
      Fax: + 65 - 6861 8115
      Ketone C-8
  • The John D. Walsh Company
    • The John D. Walsh Company, Inc
      Suppliers Since 1942
      Supplying the fragrance and flavor industry with high quality products.
      The John D. Walsh Company, Inc. has evolved from its beginnings as an agent/broker into a distributor of essential oils, aroma chemicals, concretes and absolutes. We currently represent the following companies, as their North American distributor: Destilerias Munoz Galvez, S.A. International Flavors & Fragrances PFW Aroma Chemicals B.V. Innospec Widnes Limited Hydrodiffusion de Guatemala, S. A. DSM Nutritional Products The John D. Walsh Company, Inc. is proud to be a founding member of IFEAT, an active member of IFRA, North America, and a corporate sponsor of the WFFC.
      Email: Information
      Email: Sales
      Email: Firmenich Flavor inquiries
      Voice: 973-962-1400
      Fax: 973-962-1557
      Firmenich Flavor Phone:973-962-1888
      Firmenich Flavor Fax:973-962-1898
      Methyl Hexyl Ketone
  • Treatt
    • Treatt PLC
      Innovative ingredient solutions
      World-leading innovative ingredient solutions provider for the flavour, fragrance and FMCG industries.
      We offer innovative and trend-setting product concepts for our customers, collaborating with them to create true value for their products.
      Email: Enquiries
      US Email: Enquiries
      Voice: +44 (0) 1284 702500
      Fax: +44 (0) 1284 703809
      US Voice: +1 863 668 9500
      US Fax: +1 863 668 3388
  • Ernesto Ventós
Synonyms   Articles   Notes   Search
Fragrance Demo Formulas    Flavor Demo Formulas
octan-2-one (Click)
CAS Number: 111-13-7Picture of molecule
ECHA EINECS - REACH Pre-Reg: 203-837-1
Nikkaji Web: J1.984D
Beilstein Number: 0635843
MDL: MFCD00009540
CoE Number: 153
XlogP3: 2.40 (est)
Molecular Weight: 128.21472000
Formula: C8 H16 O
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: flavor and fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist: Search
Google Patents: Search
US Patents: Search
EU Patents: Search
IBM Patents: Obtain
Pubchem Patents: Search
PubMed: Search
NCBI: Search
JECFA Food Flavoring: 288  2-octanone
Flavis Number: 07.019 (Old)
DG SANTE Food Flavourings: 07.019  octan-2-one
FEMA Number: 2802  2-octanone
FDA Mainterm: 2-OCTANONE
FDA Regulation:
Subpart F--Flavoring Agents and Related Substances
Sec. 172.515 Synthetic flavoring substances and adjuvants.
Synonyms   Articles   Notes   Search   Top
Physical Properties:
Appearance: colorless to pale yellow clear liquid (est)
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: Yes
Specific Gravity: 0.81500 to 0.81700 @  25.00 °C.
Pounds per Gallon - (est).: 6.782 to  6.798
Refractive Index: 1.41400 to 1.41700 @  20.00 °C.
Melting Point: -16.00 to  -15.00 °C. @ 760.00 mm Hg
Boiling Point: 173.00 to  175.00 °C. @ 760.00 mm Hg
Boiling Point: 94.00 to  95.00 °C. @ 50.00 mm Hg
Acid Value: 1.00 max. KOH/g
Vapor Pressure: 1.725000 mm/Hg @ 25.00 °C. (est)
Vapor Density: 4.4 ( Air = 1 )
Flash Point: 145.00 °F. TCC ( 62.78 °C. )
logP (o/w): 2.370
Soluble in:
 water, 900 mg/L @ 20 °C (exp)
Synonyms   Articles   Notes   Search   Top
Organoleptic Properties:
Odor Type: earthy
Odor Strength: medium ,
recommend smelling in a 10.00 % solution or less
 earthy  weedy  natural  woody  herbal  
Odor Description:
at 10.00 % in dipropylene glycol. 
earthy weedy natural woody herbal
 musty  ketonic  cheesy bleu cheese  cheesy parmesan cheese  earthy  dairy  
Odor Description:
Musty, ketonic, bleu and parmesan cheese-like with earthy and dairy nuances
Mosciano, Gerard P&F 21, No. 1, 33, (1996)
 dairy  waxy  cheesy  woody  mushroom  yeasty  
Taste Description:
at 10.00 ppm.  
Dairy, waxy, cheese, woody, mushroom and yeast
Mosciano, Gerard P&F 21, No. 1, 33, (1996)
Substantivity: 4 Hour(s)
Synonyms   Articles   Notes   Search   Top
Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: perfuming agents
Synonyms   Articles   Notes   Search   Top
A.C.S. International
Methyl Hexyl Ketone
Operational Capabilities
Advanced Biotech
98% min.
Odor: Camphor, Bitter
Odor: Floral, Green, Herbaceous, Fruity
Apiscent Labs
Associate Allied Chemicals
Methyl Hexyl Ketone
Augustus Oils
Methyl Hexyl Ketone
2-OCTANONE, Natural
Axxence Aromatic
Bedoukian Research
≥97.5%, FCC, Kosher
Odor: sweet, earthy, weedy, 'natural'
Use: An interesting note for lilac compositions.
Flavor: Ketonic, fermented notes
Adds ketonic notes for a variety of cheese flavors, unroasted nuts especially hazelnut and cashews.
Methyl Hexyl Ketone
Happening at Berje
CG Herbals
Methyl Hexyl Ketone
Odor: Pleasant Floral, But Bitter-Green Slightly Musty-Herbaceous
CTC Organics
Diffusions Aromatiques
Diffusions Aromatiques
Ernesto Ventós
Excellentia International
Methyl Hexyl Ketone (2-Octanone) Natural
min. 98%, Kosher
Flavor: Intense blue cheese, fruity, mushroom and green notes
2-OCTANONE adds nice fruity, blue and parmesan cheese-like notes with mushroom and dairy nuances to dairy, fruit and cooked meat flavors.
Global Essence
Methyl hexyl ketone
Indukern F&F
Indukern F&F
Inoue Perfumery
Kunshan Sainty
2-Octanone, Natural
Lluch Essence
Lluch Essence
M&U International
Odor: floral, green, herbaceous, fruity
Flavor: cheesy, sharp, ketonic (waxy note)
Odowell Co.,ltd
Methyl hexyl ketone
Methyl Hexyl Ketone, Kosher
Penta International
Penta International
Methyl hexyl ketone
Odor: sweet earthy weedy natural woody herbal green fruity wine floral green herbaceous fruity
Use: Blends-well-with - +2-heptanone Herbaceous-notes
Reincke & Fichtner
2-Octanone, ≥98%, FG
Odor: green; herbaceous; floral; fruity
Certified Food Grade Products
2-Octanone, natural, 98%, FG
SRS Aromatics
Ketone C-8
Odor: Bitter, Floral, Fruity, Green, Herbal/ Herbaceous, Musk/ Musky
For experimental / research use only.
2-Octanone >98.0%(GC)
The John D. Walsh Company
Methyl Hexyl Ketone
The Perfumers Apprentice
Methyl Hexyl Ketone
Odor: earthy weedy woody herbal
Synonyms   Articles   Notes   Search   Top
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
Xn - Harmful.
R 21 - Harmful in contact with skin.
R 36/37/38 - Irritating to eyes, respiratory system, and skin.
S 02 - Keep out of the reach of children.
S 20/21 - When using do not eat, drink or smoke.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Human Experience:
4 % solution: no irritation or sensitization.
Oral/Parenteral Toxicity:
oral-rat LD50  > 5000 mg/kg
(Katz et al., 1980)

oral-mouse LD50  [sex: M] 3823 mg/kg
(Tanii et al., 1986)

oral-mouse LD50  3870 mg/kg
(Tanii et al., 1986)

intraperitoneal-mouse LD50  800 mg/kg
"Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 4765, 1982.

oral-mouse LD50  3824 mg/kg
Toxicology Letters. Vol. 30, Pg. 13, 1986.

unreported-mouse LD50  1600 mg/kg
Journal of Medicinal Chemistry. Vol. 19, Pg. 1257, 1976.

intraperitoneal-rat LD50  800 mg/kg
"Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 4765, 1982.

oral-rat LD50  3089 mg/kg
Kodak Company Reports. Vol. #901875

Dermal Toxicity:
skin-rabbit LD50 1337 mg/kg
Kodak Company Reports. Vol. #901875

Inhalation Toxicity:
inhalation-rat LC50 2132 ppm/6hours

inhalation-rat LC50 > 2132 ppm/6H
Kodak Company Reports. Vol. #901875

Synonyms   Articles   Notes   Search   Top
Safety in Use Information:
Category: flavor and fragrance agents
Recommendation for 2-octanone usage levels up to:
  4.0000 % in the fragrance concentrate.
Maximised Survey-derived Daily Intakes (MSDI-EU): 93.00 (μg/capita/day)
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
Click here to view publication 3
 average usual ppmaverage maximum ppm
baked goods: 0.400004.00000
beverages(nonalcoholic): 0.100001.00000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: 0.200001.00000
fruit ices: 0.200001.00000
gelatins / puddings: --
granulated sugar: --
gravies: --
hard candy: 0.400004.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --
Synonyms   Articles   Notes   Search   Top
Safety References:
European Food Safety Athority(efsa): Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...
European Food Safety Authority (EFSA) reference(s):
Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Flavouring Group Evaluation 7 (FGE.07): Saturated and unsaturated aliphatic secondary alcohols, ketones and esters of secondary alcohols and saturated linear or branched-chain carboxylic acids from chemical group 5
View page or View pdf
Flavouring Group Evaluation 7, Revision 1 (FGE.07Rev1): Saturated and unsaturated aliphatic secondary alcohols, ketones and esters of secondary alcohols and saturated linear or branched-chain carboxylic acids from chemical group 5 (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Scientific opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) on a request from the Commission
View page or View pdf
Flavouring Group Evaluation 7, Revision 2 (FGE.07Rev2) : Saturated and unsaturated aliphatic secondary alcohols, ketones and esters of secondary alcohols and saturated linear or branched-chain carboxylic acids from chemical group 5
View page or View pdf
Safety and efficacy of saturated and unsaturated aliphatic secondary alcohols, ketones and esters with esters containing secondary alcohols belonging to chemical group 5 when used as flavourings for all animal species
View page or View pdf
EPI System: View
NLM Hazardous Substances Data Bank: Search
Toxicology Citations: Search
Env. Mutagen Info. Center: Search
EPA Substance Registry Services (TSCA): 111-13-7
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 8093
National Institute of Allergy and Infectious Diseases: Data
WISER: UN 1224
WGK Germany: 1
Chemidplus: 0000111137
RTECS: RH1484000 for cas# 111-13-7
Synonyms   Articles   Notes   Search   Top
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 111-13-7
Pubchem (cid): 8093
Pubchem (sid): 134974863
Flavornet: 111-13-7
Pherobase: View
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS): View
HMDB (The Human Metabolome Database): HMDB31294
FooDB: FDB003344
Export Tariff Code: 2902.20.0000
Haz-Map: View
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
Read: Under the conditions of intended use - New developments in the FEMA GRAS program and the safety assessment of flavor ingredients
Read: A GRAS assessment program for flavor ingredients
Read: Sensory testing for flavorings with modifying properties. Food Technology
Read: Criteria for the safety evaluation of flavoring substances
Read: A procedure for the safety evaluation of natural flavor complexes used as ingredients in food: essential oils
Read: FEMA Expert Panel: 30 Years of safety evaluation for the flavor industry
Read: Consumption ratio and food predominance of flavoring materials
assay: 98% minimum
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Potential Blenders and core components note
For Odor
isobutyric acidFL/FR
 cyclohexyl acetic acidFL/FR
2-methyl butyric acidFL/FR
 acetyl propionylFL/FR
 butyl butyryl lactateFL/FR
2,3-heptane dioneFL/FR
 butyric acidFL/FR
2-methyl hexanoic acidFL/FR
S-(methyl thio) butyrateFL/FR
2-methyl valeric acidFL/FR
2-methyl-2-hexenoic acidFR
 hexanoic acidFL/FR
 cyclohexyl carboxylic acidFL/FR
 filbert hexenoneFL/FR
 methyl 4-methyl valerateFL/FR
2-methyl butyl isovalerateFL/FR
 prenyl hexanoateFL/FR
 sorbyl butyrateFL/FR
 herbal ketoneFR
 nutty quinoxalineFL/FR
2-methyl heptanoic acidFL/FR
 nonanoic acidFL/FR
 undecanoic acidFL/FR
 patchouli oilFL/FR
For Flavor
No flavor group found for these
isobutyric acidFL/FR
 ethyl cyclohexyl carboxylateFL
(Z)-3-hexenoic acidFL
5-methyl hexanoic acidFL
4-methyl valeric acidFL
 prenyl hexanoateFL/FR
2,3-heptane dioneFL/FR
2-methyl valeric acidFL/FR
(E)-2-pentenoic acidFL
 hexanoic acidFL/FR
 acetoin butyrateFL
 butyl butyryl lactateFL/FR
2-methyl-4-pentenoic acidFL
4-pentenoic acidFL
 nonanoic acidFL/FR
(E)-2-octenoic acidFL
 methyl thio isovalerateFL
 cyclohexyl carboxylic acidFL/FR
 filbert hexenoneFL/FR
 methyl 4-methyl valerateFL/FR
2-methyl butyl isovalerateFL/FR
2-methyl butyric acidFL/FR
 sorbyl butyrateFL/FR
2-methyl 3-(methyl thio) furanFL
S-(methyl thio) butyrateFL/FR
 nutty quinoxalineFL/FR
2-methyl hexanoic acidFL/FR
 butyric acidFL/FR
2,4-dimethyl-2-pentenoic acidFL
3-methyl valeric acidFL
 methyl 4-(methyl thio) butyrateFL
 cyclohexyl acetic acidFL/FR
 acetyl propionylFL/FR
2-methyl heptanoic acidFL/FR
 undecanoic acidFL/FR
 patchouli oilFL/FR
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Potential Uses:
 cheese blueFL
 cheese cheddarFL
 fern fougereFR
 fungus mushroomFR
 hay new mown hay foin coupeFR
 lilac lilas syringaFR
 reseda mignonetteFR
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Occurrence (nature, food, other): note
 banana fruit
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 carrot seed
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 cayenne fruit
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 clove bud
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 clove fruit
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 corn husk oil
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 corn seed oil
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 lavandin oil china @ 1.18%
Data  GC  Search Trop  Picture
 lovage root
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 osmanthus absolute @ trace%
Data  GC  Search Trop  Picture
 peanut roasted peanut
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 potato chip
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 rue flower oil colombia @ 0.18%
Data  GC  Search Trop  Picture
 rue oil china @ 0.24%
Data  GC  Search Trop  Picture
 rue plant
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 tea leaf
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 hexyl methyl ketone
N-hexyl methyl ketone
 ketone, hexyl methyl
 methyl hexyl cetone
 methyl hexyl ketone
 methyl hexyl ketone 90
 methyl hexyl ketone, natural
 methyl N-hexyl ketone
2-octanone natural
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US Patents: 3,952,024 - Furfurylthioacetone
PubMed: Binding of carbonyl flavours to canola, pea and wheat proteins using GC/MS approach.
US Patents: 3,931,166 - Certain 2,5-dimethyl-3-thiopyrazines
PubMed: Communication: Coordination structure of bromide ions associated with hexyltrimethylammonium cations at liquid/liquid interfaces under potentiostatic control as studied by total-reflection X-ray absorption fine structure.
PubMed: Olfactory Sensitivity and Odor Structure-Activity Relationships for Aliphatic Ketones in CD-1 Mice.
PubMed: Characterization of aroma compounds of Chinese famous liquors by gas chromatography-mass spectrometry and flash GC electronic-nose.
PubMed: Brushed block copolymer micelles with pH-sensitive pendant groups for controlled drug delivery.
PubMed: Mass and Ion Transport in Ketones and Ketone Electrolytes: Comparison with Acetate Systems.
PubMed: Formation yields of C8 1,4-hydroxycarbonyls from OH + n-octane in the presence of NO.
PubMed: Brain phospholipase C, diacylglycerol lipase and monoacylglycerol lipase are involved in (±)-epibatidine-induced activation of central adrenomedullary outflow in rats.
PubMed: Analysis of quinolones by voltage-assisted liquid-phase microextraction combined with LC-MS.
PubMed: Fragrance material review on methyl hexyl oxo cyclopentanone carboxylate.
PubMed: Color, lipid oxidation, sensory quality, and aroma compounds of beef steaks displayed under different levels of oxygen in a modified atmosphere package.
PubMed: Electromembrane extraction of peptides--fundamental studies on the supported liquid membrane.
PubMed: Evaluation of parallel milliliter-scale stirred-tank bioreactors for the study of biphasic whole-cell biocatalysis with ionic liquids.
PubMed: Evaluation of the use of Syzygium cumini fruit extract as an antioxidant additive in orange juice and its sensorial impact.
PubMed: Controlling the facial selectivity of asymmetric [4+2] cyclo-additions: a concise synthesis of the cis-decalin core structure of superstolides A and B.
PubMed: Thermodynamics and activity coefficients at infinite dilution measurements for organic solutes and water in the ionic liquid N-hexyl-3-methylpyridinium tosylate.
PubMed: Comparison of volatile components in Chinese traditional pickled peppers using HS-SPME-GC-MS, GC-O and multivariate analysis.
PubMed: Solvent free oxidation of primary alcohols and diols using thymine iron(III) catalyst.
PubMed: Novel aspect of ketone action: β-hydroxybutyrate increases brain synthesis of kynurenic acid in vitro.
PubMed: Isolation and characterization of 4-tert-butylphenol-utilizing Sphingobium fuliginis strains from Phragmites australis rhizosphere sediment.
PubMed: Neurotoxicity of fungal volatile organic compounds in Drosophila melanogaster.
PubMed: Prolonged stimulus exposure reveals prolonged neurobehavioral response patterns.
PubMed: Hollow fiber-liquid-phase microextraction of fungicides from orange juices.
PubMed: Asymmetric [4+2] cycloadditions employing 1,3-dienes derived from (R)-4-t-butyldimethyl-silyloxy-2-cyclohexen-1-one.
PubMed: Purification and characterization of an anti-Prelog alcohol dehydrogenase from Oenococcus oeni that reduces 2-octanone to (R)-2-octanol.
PubMed: Widespread occurrence of estrogenic UV-filters in aquatic ecosystems in Switzerland.
PubMed: Ionic liquid based dispersive liquid-liquid microextraction for the extraction of pesticides from bananas.
PubMed: Gas chromatography-olfactometry analysis of the volatile compounds of two commercial Irish beef meats.
PubMed: Selective three-phase liquid phase microextraction of acidic compounds from foodstuff simulants.
PubMed: Chemical characterization of territorial marking fluid of male Bengal tiger, Panthera tigris.
PubMed: Templation of the excited-state chemistry of alpha-(n-alkyl) dibenzyl ketones: how guest packing within a nanoscale supramolecular capsule influences photochemistry.
PubMed: Optimization of chlorophyllase-catalyzed hydrolysis of chlorophyll in monophasic organic solvent media.
PubMed: Kinetic analysis of volatile formation in milk subjected to pressure-assisted thermal treatments.
PubMed: Glial-cytokine-neuronal interactions underlying the mechanisms of persistent pain.
PubMed: Purification, characterization, and gene cloning of glycerol dehydrogenase from Hansenula ofunaensis, and its expression for production of optically active diol.
PubMed: Anti-prelog reduction of prochiral carbonyl compounds by Oenococcus oeni in a biphasic system.
PubMed: Chemical boundaries for detection of eye irritation in humans from homologous vapors.
PubMed: Dominant role for calpain in thromboxane-induced neuromicrovascular endothelial cytotoxicity.
PubMed: Stability of immobilized soybean lipoxygenase in selected organic solvent media.
PubMed: Stereoselective synthesis of c3-c12 dihydropyran portion of antitumor laulimalide using copper-catalyzed oxonium ylide formation-[2,3] shift.
PubMed: 1,4-hydroxycarbonyl products of the OH radical initiated reactions of C5-C8 n-alkanes in the presence of NO.
PubMed: Bis{1-n-hexyl-3-methyl-4-[1-(phenylimino)propyl]-1H-pyrazol-5-olato}copper(II): a new copper(II) complex with a chelating alkylpyrazolone-based enamine.
PubMed: Characterization of French and Spanish dry-cured hams: influence of the volatiles from the muscles and the subcutaneous fat quantified by SPME-GC.
PubMed: Designing the "search pathway" in the development of a new class of highly efficient stereoselective hydrosilylation catalysts.
PubMed: High-yield conversion of (R)-2-octanol from the corresponding racemate by stereoinversion using Candida rugosa.
PubMed: Bimetallic isopropoxides M[Al(OC(3)H(i)(7))(4)](3) (M = Pr, Nd)--catalyzed reduction of 2-octanone and benzophenone.
PubMed: Controlled production of Camembert-type cheeses. Part II. Changes in the concentration of the more volatile compounds.
PubMed: Use of an ionic liquid in a two-phase system to improve an alcohol dehydrogenase catalysed reduction.
PubMed: Expression of adhesion molecules by sphingosine 1-phosphate and histamine in endothelial cells.
PubMed: Volatiles in a sausage surface model-influence of Penicillium nalgiovense, Pediococcus pentosaceus, ascorbate, nitrate and temperature.
PubMed: An efficient direct alpha-alkylation of ketones with primary alcohols catalyzed by [Ir(cod)Cl]2/PPh3/KOH system without solvent.
PubMed: Analysis of ketones by selected ion flow tube mass spectrometry.
PubMed: Synthesis of (4R,6S,7R)-7-hydroxy-4,6-dimethyl-3-nonanone and (3R,5S,6R)- 6-hydroxy-3,5-dimethyl-2-octanone, the pheromone components of the bostrychid beetle, Dinoderus bifoveolatus.
PubMed: Associative learning of complex odours in parasitoid host location.
PubMed: Relationship between molecular structure, concentration and odor qualities of oxygenated aliphatic molecules.
PubMed: Chlorpromazine inhibits the glucocorticoid receptor-mediated gene transcription in a calcium-dependent manner.
PubMed: Aroma active components in aqueous kiwi fruit essence and kiwi fruit puree by GC-MS and multidimensional GC/GC-O.
PubMed: Influence of lipid fraction, emulsifier fraction, and mean particle diameter of oil-in-water emulsions on the release of 20 aroma compounds.
PubMed: Selective Oxidation of Vinyl Ethers and Silyl Enol Ethers with Hydrogen Peroxide Catalyzed by Peroxotungstophosphate.
PubMed: An enantiospecific approach to tricyclic sesquiterpenes mayurone and thujopsenes.
PubMed: Asymmetric reduction of ketones with catecholborane using 2,6-BODOL complexes of titanium(IV) as catalysts.
PubMed: Interactions between artificial saliva and 20 aroma compounds in water and oil model systems.
PubMed: Signalling mechanisms underlying the myogenic response in human subcutaneous resistance arteries.
PubMed: Efficient oxidation of alcohols to carbonyl compounds with molecular oxygen catalyzed by N-hydroxyphthalimide combined with a Co species
PubMed: Interactions between methyl ketones and beta-lactoglobulin: sensory analysis, headspace analysis, and mathematical modeling.
PubMed: Blocking and the detection of odor components in blends.
PubMed: Interactions of flavor compounds with pectic substances.
PubMed: Oxidative cleavage of the octyl side chain of 1-(3,4-dichlorobenzyl)-5-octylbiguanide (OPB-2045) in rat and dog liver preparations.
PubMed: Effect of aeration during cell growth on ketone reactions by immobilized yeast.
PubMed: Interactions between aroma and edible films. 1. Permeability Of methylcellulose and low-density polyethylene films to methyl ketones.
PubMed: Solvent-modified solid-phase microextraction for the determination of diazepam in human plasma samples by capillary gas chromatography.
PubMed: An analysis of blocking in odorant mixtures: an increase but not a decrease in intensity of reinforcement produces unblocking.
PubMed: Neighboring Group Participation in a Regio- and Stereoselective Chlorination of a Bicyclo[2.2.2]octanone.
PubMed: Enhanced sensitivity to androstenone following regular exposure to pemenone.
PubMed: Effects of solvation on partition and dimerization of benzoic acid in mixed solvent systems.
PubMed: Ketone EC50 values in the Microtox test.
PubMed: Structure, stereochemistry, and thermal isomerization of the male sex pheromone of the longhorn beetle Anaglyptus subfasciatus.
PubMed: Immiscible organic solvent inactivation of urease, chymotrypsin, lipase, and ribonuclease: separation of dissolved solvent and interfacial effects.
PubMed: Juvenile hormone esterase purified by affinity chromatography with 8-mercapto-1,1,1-trifluoro-2-octanone as a rationally designed ligand.
PubMed: Sensory irritation and pulmonary irritation of n-methyl ketones: receptor activation mechanisms and relationships with threshold limit values.
PubMed: Effect of some metallic cations and organic compounds on the O-hexyl O-2,5-dichlorophenyl phosphoramidate hydrolysing activity in hen plasma.
PubMed: Competitive inhibition of lipolytic enzymes. VII. The interaction of pancreatic phospholipase A2 with micellar lipid/water interfaces of competitive inhibitors.
PubMed: Electroantennogram response of alfalfa seed chalcid,Bruchophagus roddi (Hymenoptera: Eurytomidae) to host- and nonhost-plant volatiles.
PubMed: Antidopaminergic effects of the stereoisomers of N-[(1-alkyl-2- pyrrolidinyl)methyl]-5-sulfamoylbenzamides and -2,3-dihydrobenzofuran-7-carboxamides.
PubMed: Inhibition of cathepsin B and papain by peptidyl alpha-keto esters, alpha-keto amides, alpha-diketones, and alpha-keto acids.
PubMed: Volatile methyl ketone seed-germination inhibitors fromAmaranthus palmeri S. Wats. Residues.
PubMed: Experimental study on the enhancement of the neurotoxicity of methyl n-butyl ketone by non-neurotoxic aliphatic monoketones.
PubMed: Neurophysiological studies on the relation between the structural properties and neurotoxicity of aliphatic hydrocarbon compounds in rats.
PubMed: Volatile constituents of wolf (Canis lupus) urine as related to gender and season.
PubMed: Further studies on ketone neurotoxicity and interactions.
PubMed: [An experimental study on the neurotoxicity of 2-octanone and 2-hexanol, a metabolite of n-hexane].
PubMed: Commercial-grade methyl heptyl ketone (5-methyl-2-octanone) neurotoxicity: contribution of 5-nonanone.
PubMed: Gas-chromatographic resolution of enantiomeric secondary alcohols. Stereoselective reductive metabolism of ketones in rabbit-liver cytosol.
PubMed: Cycloalkanones. 9. Comparison of analogues which inhibit cholesterol and fatty acid synthesis.
PubMed: Cycloalkanones. 7. Hypocholesterolemic activity of aliphatic compounds related to 2,8-dibenzylcyclooctanone.
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